A osteomalácia oncogênica é uma condição causada por um tumor que faz com que os ossos fiquem fracos. Isso acontece quando um tumor libera uma substância chamada fator de crescimento de fibroblastos 23 (FGF23). O FGF23 impede que os rins absorvam fosfato, uma substância importante para manter os ossos fortes e saudáveis. Por isso, essa doença causa amolecimento e enfraquecimento dos ossos (o que é chamado de osteomalácia). A doença também provoca várias alterações químicas no corpo, como níveis altos de fosfato na urina (hiperfosfatúria) e níveis baixos de fosfato no sangue (hipofosfatemia). A maioria dos tumores que causam a osteomalácia oncogênica são pequenos e de crescimento lento. Esses tumores geralmente aparecem na pele, nos músculos ou nos ossos das extremidades (braços e pernas), ou na região dos seios da face, perto da cabeça. A maioria desses tumores é benigna, o que significa que não é câncer. O motivo exato pelo qual esses tumores associados à osteomalácia oncogênica se desenvolvem não é conhecido. A doença é diagnosticada quando uma pessoa apresenta sintomas como enfraquecimento dos ossos e níveis elevados de fosfato na urina, e um tumor é encontrado por exames de imagem do corpo. O tratamento da doença consiste na remoção cirúrgica do tumor. Os sintomas da doença, incluindo o enfraquecimento dos ossos, geralmente desaparecem depois que o tumor é removido.
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A osteomalácia oncogênica é uma condição causada por um tumor que faz com que os ossos fiquem fracos. Isso acontece quando um tumor libera uma substância chamada fator de crescimento de fibroblastos 23 (FGF23). O FGF23 impede que os rins absorvam fosfato, uma substância importante para manter os ossos fortes e saudáveis. Por isso, essa doença causa amolecimento e enfraquecimento dos ossos (o que é chamado de osteomalácia). A doença também provoca várias alterações químicas no corpo, como níveis altos de fosfato na urina (hiperfosfatúria) e níveis baixos de fosfato no sangue (hipofosfatemia). A maioria dos tumores que causam a osteomalácia oncogênica são pequenos e de crescimento lento. Esses tumores geralmente aparecem na pele, nos músculos ou nos ossos das extremidades (braços e pernas), ou na região dos seios da face, perto da cabeça. A maioria desses tumores é benigna, o que significa que não é câncer. O motivo exato pelo qual esses tumores associados à osteomalácia oncogênica se desenvolvem não é conhecido. A doença é diagnosticada quando uma pessoa apresenta sintomas como enfraquecimento dos ossos e níveis elevados de fosfato na urina, e um tumor é encontrado por exames de imagem do corpo. O tratamento da doença consiste na remoção cirúrgica do tumor. Os sintomas da doença, incluindo o enfraquecimento dos ossos, geralmente desaparecem depois que o tumor é removido.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 13 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 35 características clínicas mais associadas, ordenadas por frequência.
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Publicações mais relevantes
Bilateral femoral neck fractures and 11 rib fractures unmask tumour-induced osteomalacia caused by a phosphaturic mesenchymal tumour.
Phosphaturic mesenchymal tumours (PMTs) are rare benign tumours that secrete fibroblast growth factor 23 (FGF23), leading to phosphate wasting, disordered vitamin D metabolism and impaired bone mineralisation, clinically known as tumour-induced osteomalacia. PMTs are frequently misdiagnosed due to rarity and non-specific presentation. We report a case of a male in his 60s who presented to the hospital with 7 years of progressive muscle weakness and diffuse pain, resulting in inability to walk. His work-up was significant for hypophosphataemia with imaging showing chronic bilateral femoral neck fractures and 11 posterior rib fractures. Copper-64 DOTA-Phe1-Tyr3-Thr8-octreotate positron emission tomography/CT demonstrated increased uptake within the left femur. Venous sampling revealed elevated FGF23. He underwent resection of the femoral tumour with histology consistent with PMT. Within 1 year of resection, the patient showed significant improvement. This case highlights the diagnostic challenge of PMTs and the dramatic improvement that can occur following resection. .
Fibroblast growth factor 23-induced hypophosphatemia in a malignant phosphaturic mesenchymal tumor: presentation of a rare case.
Tumor-induced osteomalacia is a rare paraneoplastic disorder caused by excess fibroblast growth factor 23 (FGF23), most often produced by phosphaturic mesenchymal tumors. Delayed diagnosis may result in severe metabolic and skeletal complications. We report the case of a 32-year-old woman with a three-year history of progressive weakness and a rapidly enlarging thoracic mass. Imaging revealed an 18 × 13 cm highly vascularized thoracic lesion with multiple lytic bone metastases. Laboratory evaluation showed severe hypophosphatemia (0.9 mg/dL), renal phosphate wasting (fractional excretion of phosphate 24.5%), elevated intact parathyroid hormone, low vitamin D levels, and markedly increased serum FGF23 (7926 kRU/L). Histopathological examination and immunohistochemistry demonstrated a malignant phosphaturic mesenchymal tumor with positivity for CD56, SATB2, and SSTR2A. This case highlights the aggressive clinical behavior that malignant phosphaturic mesenchymal tumors may exhibit, including extensive local invasion, metastatic disease, and profound metabolic derangements. The diagnosis of tumor-induced osteomalacia requires a high index of suspicion and an integrated approach combining biochemical evaluation, functional imaging, and detailed pathological assessment. Tumor-induced osteomalacia should be considered in patients with persistent hypophosphatemia and phosphate wasting. Early recognition is essential, as complete surgical resection remains the only curative option. In advanced or unresectable disease, management is challenging and may be limited by tumor burden and access to targeted therapies, including anti-FGF23 agents, which offer biochemical and symptomatic benefit in selected cases.
Tumor-Induced Osteomalacia Mimicking Metastases on Ga-68 DOTATATE Scan: A Rare Pericytic Variant of Phosphaturic Mesenchymal Tumor.
Oncogenic osteomalacia (OOM), also known as tumor-induced osteomalacia (TIO), is a rare paraneoplastic syndrome caused by excessive production of fibroblast growth factor 23 (FGF23) by mesenchymal tumors. This leads to renal phosphate wasting, hypophosphatemia, decreased 1,25-dihydroxy vitamin D levels, and impaired bone mineralization. Patients often present with progressive muscle weakness, diffuse bone pain, and recurrent fractures, with symptoms frequently preceding diagnosis by several years due to the non-specific nature of hypophosphatemia and its exclusion from routine laboratory panels. We present the case of a 63-year-old man with a seven-year history of progressive musculoskeletal symptoms and multiple fractures. Despite extensive prior evaluations, his diagnosis was delayed until advanced imaging with Ga-68 DOTATATE PET/CT identified a somatostatin receptor-positive lesion in the right superior pubic ramus. Histopathological analysis confirmed a pericytic neoplasm, a rare histologic variant of phosphaturic mesenchymal tumor, consistent with the etiology of OOM. Laboratory evaluation demonstrated profound hypophosphatemia, elevated FGF23 levels, and reduced 1,25-dihydroxy vitamin D. Given the patient's elevated surgical risk, percutaneous cryoablation of the tumor was performed, resulting in normalization of serum phosphate levels and resolution of clinical symptoms. This case highlights the diagnostic challenges associated with OOM, the utility of somatostatin receptor-based PET/CT in tumor localization, and the importance of considering TIO in patients with unexplained hypophosphatemia and osteomalacia. Prompt recognition and surgical intervention can lead to complete resolution of symptoms and prevent long-term skeletal complications.
Skeletal involvement in tumor-induced osteomalacia.
Tumor-induced osteomalacia (TIO) is an ultrarare paraneoplastic syndrome of abnormal phosphate and vitamin D metabolism secondary to the overproduction of fibroblast growth factor 23 by small-sized mesenchymal tumors typically located in soft tissues and bone. The tumor has adverse effects on bone and patients complain of skeletal symptoms and, in severe cases, they suffer multiple devastating fractures. Specific features may characterize the histology of tumors located in bone with respect to those found in extra-skeletal sites. Indeed, the matrix may contain foci resembling primitive cartilage and osteoid. Light microscopy of bone biopsy samples reveal accumulation of osteoid due to thickening of osteoid seams and, if tetracyclines were sequentially administrated, fluorescence microscopy reveals prolongation of the mineralization lag time. Areal BMD assessed by DXA is significantly lower at both the lumbar and femoral sites in patients with TIO and values of trabecular bone score are significantly reduced with respect to healthy individuals. Patients with TIO are also characterized by significant impairment in bone quality at both the trabecular and cortical compartment when evaluated by HR-pQCT. Successful surgical removal of the causative tumor completely reverts biochemical abnormalities. BMD accrual is impressive in the short term at the central (spine and hip) level but may take longer to improve, together with microstructural parameters, at peripheral sites (radius and tibia). Future studies should address effects of long-term treatment on quality-of-life outcomes related to irreversible events, such as vertebral fractures. This is particularly important in patients with a heavy burden due to a long-standing disease. Tumor-induced osteomalacia is an ultrarare paraneoplastic syndrome of abnormal phosphate and vitamin D metabolism characterized by increased phosphate loss consequent to overproduction of the hormone fibroblast growth factor 23. Phosphorus is fundamental for muscle function and bone mineralization. Therefore, when values in the body are very low, there are a number of negative consequences on many skeletal aspects. In addition to skeletal pain, patients may suffer from devastating multiple fractures. When the tumor is successfully removed, biochemical and skeletal alterations are reversed. However, in those with longstanding disease and fractures, full recovery may not be complete.
Phosphaturic Mesenchymal Tumor in the Foot Detected by 99m Tc-FAPI-46 SPECT/CT and 18 F-FDG PET/CT.
A 58-year-old woman presented with disabling bone pain and muscle weakness. Laboratory tests were unremarkable, except for decreased serum phosphate and elevated urine phosphate levels. A 99m Tc-MDP scan revealed multiple sites of bone fractures. Both 18 F-FDG PET/CT and 99m Tc-FAPI-46 scans identified a lesion in the left heel, which was later resected and diagnosed as phosphaturic mesenchymal tumor on pathologic evaluation. This case represents a pioneering experience in utilizing FAPI for detecting the origin of tumor-induced osteomalacia. It underscores the potential utility of various radiopharmaceuticals in the diagnostic workup of these patients.
Publicações recentes
Oncogenic Osteomalacia Due to Tumor in the Femoral Head Managed by Excision and Femoral Head Preservation: A Case Report.
Diffuse and Prolonged Bone Pain Revealing Tumor-Induced Osteomalacia: A Case Report.
Tumor-Induced Osteomalacia Mimicking Metastases on Ga-68 DOTATATE Scan: A Rare Pericytic Variant of Phosphaturic Mesenchymal Tumor.
[Forearm fracture revealing oncogenic osteomalacia].
Diagnostic Journey in the Recognition of Oncogenic Osteomalacia.
📚 EuropePMC211 artigos no totalmostrando 192
Bilateral femoral neck fractures and 11 rib fractures unmask tumour-induced osteomalacia caused by a phosphaturic mesenchymal tumour.
BMJ case reportsFibroblast growth factor 23-induced hypophosphatemia in a malignant phosphaturic mesenchymal tumor: presentation of a rare case.
Clinical biochemistryBiochemical evaluation of X-linked hypophosphatemia and tumor-induced osteomalacia: insights into diagnosis and management.
Frontiers in endocrinologyTumor-Induced Osteomalacia Mimicking Metastases on Ga-68 DOTATATE Scan: A Rare Pericytic Variant of Phosphaturic Mesenchymal Tumor.
Radiology case reportsSurgical Treatment for Osteomalacia Induced by Causative Tumor in the Knee Joint Region: A Single-Center Retrospective Clinical Study Over 10 Years.
Orthopaedic surgery[Forearm fracture revealing oncogenic osteomalacia].
La Revue du praticienSkeletal involvement in tumor-induced osteomalacia.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchCase Report with Literature Review: Tumor-induced osteomalacia from a soft-tissue phosphaturic mesenchymal tumor of the trunk.
Frontiers in endocrinologyA nomogram for predicting surgery outcome of tumor-induced osteomalacia: a case-control study.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USAIntegrating single-cell and bulk transcriptome analysis of fibroblast growth factor 23 (FGF23)-producing mesenchymal tumors reveals molecular basis of its secretory phenotype.
BoneDiagnostic Journey in the Recognition of Oncogenic Osteomalacia.
JCEM case reportsFailure of femoral internal fixation device secondary to phosphaturic mesenchymal tumor: a case report and literature review.
BMC musculoskeletal disordersPhosphate, Fractures, and Frustration-A Missed Diagnosis of Oncogenic Osteomalacia Leading to Multisystem Complication.
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JCEM case reportsPHEX Protein in the Parathyroid Gland Contributes to Phosphate Sensing.
The Journal of clinical endocrinology and metabolismPostoperative outcome and clinical management of tumor-induced osteomalacia: a single-center retrospective cohort study on 117 patients.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USAExploring the Role of FGF7 in Tumor-Induced Osteomalacia. Clinic-Pathologic Analysis in a Patient with a Sino-Nasal Phosphaturic Mesenchymal Tumor.
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The National medical journal of IndiaUnusual Association of Partial Fanconi Syndrome and Tumor-Induced Osteomalacia Revealed by Multiple Vertebral Fractures.
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The Journal of clinical endocrinology and metabolismTreatment Advances in Tumor-Induced Osteomalacia.
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Frontiers in endocrinologyAcquired hypophosphatemic osteomalacia: case series from a Peruvian referral center (1999-2023).
Archives of osteoporosisPhosphaturic Mesenchymal Tumor and Tumor-Induced Osteomalacia: A Report of 5 Cases, Including 2 Skull Base Cases With Arterial Spin Label Perfusion.
Journal of computer assisted tomographyA Rare Case of Tumor-Induced Osteomalacia Due to Mesenchymal Tumor at Foramen Magnum Diagnosed Preoperatively on 68 Ga DOTATATE PET/CT.
Clinical nuclear medicineModel-Informed Approach to Recommend Burosumab Dosing Regimens for Pediatric and Adult Patients With the Ultrarare Disease Tumor-Induced Osteomalacia.
Clinical pharmacology and therapeuticsProgressive bone pain caused by a phosphaturic mesenchymal tumor in the left femur: a case report and literature review.
The Journal of international medical researchFGF23-secreting sinonasal tumour presenting with acute subdural haemorrhage and tumour-induced osteomalacia.
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Orthopaedic surgeryA Rare Association Between Osteomalacia, Phosphaturic Mesenchymal Tumor, and Ovarian Cancer: A Case Report and Literature Review.
Calcified tissue internationalA Phosphaturic Mesenchymal Tumor Presenting as Reversible Metabolic Myopathy.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi ArabiaTumour-induced osteomalacia: the long road to diagnosis and recovery.
BMJ case reportsPhosphaturic mesenchymal tumor-induced bilateral osteomalacia femoral neck fractures: a case report.
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Current opinion in endocrinology, diabetes, and obesitySuccessful Superficial Blood Sampling to Localize a Fibroblast Growth Factor-23-Producing Tumor.
The American journal of case reportsPreoperative evaluation and orthopedic surgical strategies for tumor-induced osteomalacia.
Journal of bone oncologyIntracranial Phosphaturic Mesenchymal Tumors: A Systematic Literature Review of a Rare Entity.
World neurosurgeryTumor-induced Osteomalacia Successfully Treated by En Bloc Tumor Excision and Reconstruction Using a Tumor-bearing Frozen Autograft: A Case Report.
Anticancer researchA Retrospective Cohort of Tumor-Induced Osteomalacia and Case Series of Malignant Disease.
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchAcquired Forms of Fibroblast Growth Factor 23-Related Hypophosphatemic Osteomalacia.
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World neurosurgery[FGF23 tumor induced osteomalacia with localization of neoplasm in the tympanic cavity].
Vestnik otorinolaringologiiTumor-induced osteomalacia.
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BMJ case reportsAcquired disorders of phosphaturia: Beyond tumor-induced osteomalacia.
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The Journal of clinical endocrinology and metabolismEpidemiology of Tumor-Induced Osteomalacia in Germany Based on Real World Data.
Calcified tissue international[Clinical features, diagnostics and treatment of FGF23 secreting tumors: series of 40 clinical cases].
Problemy endokrinologiiSpinal phosphaturic mesenchymal tumors: a rare etiology causing tumor-induced osteomalacia-a review of experience at a UK tertiary referral center and literature review.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research SocietyTumor-induced osteomalacia: An overview.
Best practice & research. Clinical endocrinology & metabolismTumor-induced Osteomalacia: A Case Report and Etiological Analysis with Literature Review.
Orthopaedic surgeryOncogenic Osteomalacia: Challenges in Diagnosis.
Indian journal of surgical oncologyPhosphaturic mesenchymal tumor: two cases highlighting differences in clinical and radiologic presentation.
Skeletal radiologySinonasal phosphaturic mesenchymal tumour: radiation oncologist's perspective.
BMJ case reportsIncreased Uptake of Brown Tumor in 99m Tc-HYNIC-TOC Scintigraphy Mimicking Postoperative Recurrence of Tumor-Induced Osteomalacia.
Clinical nuclear medicineBurosumab Improves Patient-Reported Outcomes in Adults With Tumor-Induced Osteomalacia: Mixed-Methods Analysis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchLung Nodule as Culprit Lesion Causing Recurrent Tumor-Induced Osteomalacia Revealed by 68 Ga-DOTATATE PET/CT.
Clinical nuclear medicineDiagnosis and management of tumor-induced osteomalacia: a single center experience.
EndocrineSkeletal Perturbations Following Sudden Stimuli.
The Journal of clinical endocrinology and metabolismOccipital bone and tumor-induced osteomalacia: a rare tumor site for an uncommon paraneoplastic syndrome.
Archives of osteoporosisTumor-induced osteomalacia combined with increased bone resorption postoperatively: A case report.
MedicineOncogenic osteomalacia: culprit tumor in the second toe.
QJM : monthly journal of the Association of PhysiciansTumor-Induced Osteomalacia: A Case Report of Rare Disease and Literature review.
South Asian journal of cancerTumor-Induced Osteomalacia- Like Syndrome with Rickets and Infantile Hepatic Hemangioendothelioma.
Indian journal of pediatricsTumor-Induced Osteomalacia in Patients With Malignancy: A Meta-analysis and Systematic Review of Case Reports.
The Journal of clinical endocrinology and metabolismShift in Calcium From Peripheral Bone to Axial Bone After Tumor Resection in Patients With Tumor-Induced Osteomalacia.
The Journal of clinical endocrinology and metabolism[Rare causes of Hypophosphatemia: diagnostic approach].
Revue medicale suissePatterns of symptoms and insufficiency fractures in patients with tumour-induced osteomalacia.
The bone & joint journalSphenoid sinus is a rare site for tumor-induced osteomalacia: A case report and literature review.
Frontiers in endocrinologyMinimally invasive approach for tumor-induced osteomalacia: A case report.
Asian journal of surgeryImaging characteristics of phosphaturic mesenchymal tumors.
Acta radiologica (Stockholm, Sweden : 1987)Tumor-induced Osteomalacia Secondary to Phosphaturic Mesenchymal Tumor.
Radiology. Imaging cancerTumor induced osteomalacia from a peripheral mesenchymal tumour of the foot.
Foot (Edinburgh, Scotland)Ultra-High Performance Liquid Chromatography-Mass Spectrometry-based Serum Metabolomics for Early Diagnosis of Refractory Tumor-induced Osteomalacia: A Case-control Study.
The Journal of clinical endocrinology and metabolismIntact Fibroblast Growth Factor 23 Concentrations in Hypophosphatemic Disorders.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsSporadic hypophosphatemic osteomalacia combined with psoriasis: A rare case report and a brief review of the literature.
International journal of rheumatic diseasesTumour-induced osteomalacia (TIO).
Endokrynologia PolskaMisdiagnosis and Mistreatment of a Rare Case of Intracranial Oncogenic Osteomalacia with an Altered Amino Acid Profile.
Medicina (Kaunas, Lithuania)Global guidance for the recognition, diagnosis, and management of tumor-induced osteomalacia.
Journal of internal medicineAppropriate dosing of burosumab in tumor-induced osteomalacia.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USAThe Nose that Broke the Hip! Tumor Induced Osteomalacia Secondary to Phosphaturic Mesenchymal Nasal Tumor : A Case Report.
Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of IndiaNew treatments for rare bone diseases: hypophosphatemic rickets/osteomalacia.
Archives of endocrinology and metabolismTumour-induced osteomalacia due to residual benign glomangioma.
BMJ case reportsThe efficacy and safety of burosumab in two patients with cutaneous skeletal hypophosphatemia syndrome.
Bone[FGF23 tumor induced osteomalacia].
Problemy endokrinologiiHyperparathyroidism in a Large Cohort of Chinese Patients With Tumor-induced Osteomalacia.
The Journal of clinical endocrinology and metabolismTumor-induced Osteomalacia: A Comprehensive Review.
Endocrine reviewsTumour-induced osteomalacia due to a durally-based intracranial phosphaturic mesenchymal tumour.
BMJ case reportsPhosphatonins: From Discovery to Therapeutics.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsA Dancer with Fractures: What Lies Beneath?
Digestive diseases and sciencesHigh prevalence of vertebral deformity in tumor-induced osteomalacia associated with impaired bone microstructure.
Journal of endocrinological investigationDetermination of FGF23 Levels for the Diagnosis of FGF23-Mediated Hypophosphatemia.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research[Tumor-induced osteomalacia caused by an orbital tumor: a case report].
[Zhonghua yan ke za zhi] Chinese journal of ophthalmologyOncogenic osteomalacia - detection of the tumour site upon physical examination.
Endokrynologia PolskaTumor-induced osteomalacia combined with acromegaly: A case report.
Annals of the New York Academy of SciencesNovel Therapeutic Agents for Rare Diseases of Calcium and Phosphate Metabolism.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolismeLong-term use of burosumab for the treatment of tumor-induced osteomalacia.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USAOvarian Teratoma Causing Oncogenic Osteomalacia: An Instance of Serendipity.
Journal of obstetrics and gynaecology of IndiaTumour-induced osteomalacia: a rare cause of chronic pain and weakness.
Practical neurologyIntracranial phosphaturic mesenchymal tumors. A case report and review of literature.
Neuropathology : official journal of the Japanese Society of NeuropathologyTumor-Induced Osteomalacia: A Systematic Clinical Review of 895 Cases.
Calcified tissue internationalTumor-induced osteomalacia characterized by "painful knee joint with difficulty in moving": a case report.
BMC endocrine disordersBone Volumetric Density, Microarchitecture, and Estimated Bone Strength in Tumor-Induced Rickets/Osteomalacia Versus X-linked Hypophosphatemia in Chinese Adolescents.
Frontiers in endocrinologyClinical Challenges in Diagnosis, Tumor Localization and Treatment of Tumor-Induced Osteomalacia: Outcome of a Retrospective Surveillance.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchThe Measurement and Interpretation of Fibroblast Growth Factor 23 (FGF23) Concentrations.
Calcified tissue internationalA literature review to understand the burden of disease in people living with tumour-induced osteomalacia.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USAChallenging case of tumour-induced osteomalacia.
BMJ case reportsPhosphaturic Mesenchymal Tumor.
AJNR. American journal of neuroradiologyTumor-induced Osteomalacia: A Systematic Review and Individual Patient's Data Analysis.
The Journal of clinical endocrinology and metabolismPhosphaturic Mesenchymal Tumor in the Maxillofacial Region: A Diagnostic Dilemma.
Journal of maxillofacial and oral surgeryPersistence and recurrence in tumor-induced osteomalacia: A systematic review of the literature and results from a national survey/case series.
EndocrineRickets guidance: part II-management.
Pediatric nephrology (Berlin, Germany)Hypophosphatemia related to a neuro-endocrine tumor of the pancreas: A case report.
Clinical biochemistryFalse-Positive 68Ga-DOTATATE PET/CT Findings in Hereditary Hypophosphatemia-Osteomalacia Mimicking Culprit Lesions of Tumor-Induced Osteomalacia.
Journal of nuclear medicine technologyDiagnostic Utility of Somatostatin Receptor 2A Immunohistochemistry for Tumor-induced Osteomalacia.
The Journal of clinical endocrinology and metabolismTumor-induced Osteomalacia in a Boy with Maxillary Ossifying Fibroma.
Journal of clinical research in pediatric endocrinology[Tumor localization and treatment of tumor-induced osteomalacia].
Zeitschrift fur RheumatologieA rare combination of tumor-induced osteomalacia caused by sinonasal glomangiopericytoma and coexisting parathyroid adenoma: case report and literature review.
BMC endocrine disordersSerum Metabolomics Reveals Dysregulation and Diagnostic Potential of Oxylipins in Tumor-induced Osteomalacia.
The Journal of clinical endocrinology and metabolismTumour-induced osteomalacia due to thymolipoma.
The National medical journal of IndiaFavorable effects of burosumab on tumor-induced osteomalacia caused by an undetectable tumor: A case report.
MedicineBone Impairment in a Large Cohort of Chinese Patients With Tumor-Induced Osteomalacia Assessed by HR-pQCT and TBS.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchFGF23 and Hypophosphatemic Rickets/Osteomalacia.
Current osteoporosis reports[Chronic progressive bone pain in an 82-year-old male patient].
Der InternistRadiotherapy for a rare phosphaturic mesenchymal tumor in the middle ear presenting with oncogenic osteomalacia: A case report.
MedicineTumor-induced osteomalacia - a mystery illness beyond aches, pains, and depression.
Endocrine regulationsPhosphaturic mesenchymal tumors: radiological aspects and suggested imaging pathway.
La Radiologia medicaBreast Carcinoma Shown on 99mTc-HYNIC-TOC Study Performed to Evaluate Tumor-Induced Osteomalacia.
Clinical nuclear medicine[Eosinophilic solid and cystic renal cell carcinoma with tumor-induced osteomalacia: report of a case].
Zhonghua bing li xue za zhi = Chinese journal of pathologyLow Levels of Serum Sclerostin in Adult Patients With Tumor-Induced Osteomalacia Compared With X-linked Hypophosphatemia.
The Journal of clinical endocrinology and metabolismClinical, morphological and immunohistochemical analysis of 13 cases of phosphaturic mesenchymal tumor - A holistic diagnostic approach.
Annals of diagnostic pathologyA Case of Hypophosphatemia due to Oncogenic Osteomalacia in a Patient with Natural Killer T-Cell Lymphoma.
Kidney & blood pressure researchDiagnosis and Management of Tumor-induced Osteomalacia: Perspectives From Clinical Experience.
Journal of the Endocrine SocietyEthmoid glomangioma and oncogenic osteomalacia: a case report.
Journal of medical case reportsRenal Phosphate Wasting Due to Tumor-Induced (Oncogenic) Osteomalacia.
CureusOncogenic osteomalacia secondary to glomus tumor.
Endocrinology, diabetes & metabolism case reportsTumor induced osteomalacia: A single center experience on 17 patients.
BoneOncogenic osteomalacia related to an intramuscular mesenchymal tumor of the scalene muscles.
Kidney internationalProlonged Hypophosphatemia and Intensive Care After Curative Surgery of Tumor Induced Osteomalacia: A Case Report.
Frontiers in endocrinologyChallenges in the management of tumor-induced osteomalacia (TIO).
BoneA Rare Case of Hypophosphataemic Osteomalacia in von Recklinghausen Neurofibromatosis.
European journal of case reports in internal medicineMicroarchitectural parameters and bone mineral density in patients with tumour-induced osteomalacia by HR-pQCT and DXA.
Clinical endocrinologyImpaired bone microarchitecture and strength in patients with tumor-induced osteomalacia.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchBurosumab for Tumor-Induced Osteomalacia: Not Enough of a Good Thing.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchThe phosphaturic mesenchymal tumor as a cause of oncogenic osteomalacia. Three cases and review of the literature.
Revista espanola de cirugia ortopedica y traumatologia (English ed.)Utility of 18F-AlF-NOTA-Octreotide PET/CT in the Localization of Tumor-Induced Osteomalacia.
The Journal of clinical endocrinology and metabolismHypophosphatemic Osteomalacia in a Young Adult.
CureusEpidemiology of Tumor-Induced Osteomalacia in Denmark.
Calcified tissue internationalConsensus on clinical management of tumor-induced osteomalacia.
Chinese medical journalSpinal Intradural Phosphaturic Mesenchymal Tumor.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiquesTumor-Induced Osteomalacia: Treatment Progress Using Burosumab, an Anti-FGF23 Monoclonal Antibody.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchComparison of 18 F-FDG PET/CT and 68 Ga-DOTATATE PET/CT in the Targeted Imaging of Culprit Tumors Causing Osteomalacia.
Orthopaedic surgeryPersistent phosphaturic mesenchymal tumor causing tumor-induced osteomalacia treated with image-guided ablation.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USADiagnostic utility of Ga-68 DOTA-SSTR and F-18 FDG PET/CT in the detection of culprit tumours causing osteomalacia: a systematic review and meta-analysis.
Nuclear medicine communicationsDiagnostic performance of 68Ga-DOTATOC PET/CT in tumor-induced osteomalacia.
Annals of nuclear medicineParaneoplastic Secretion of Multiple Phosphatonins From a Deep Fibrous Histiocytoma Causing Oncogenic Osteomalacia.
The Journal of clinical endocrinology and metabolismNasal hemangiopericytoma presenting with oncogenic osteomalasia: A case report and literature review.
Current problems in cancerAmeloblastic Fibroodontoma of Mandible Causing Tumor Induced Osteomalacia: A Case Report with Review of 88 Phosphaturic Oral Neoplasms.
Head and neck pathology[Tumor induced osteomalacia].
Vnitrni lekarstviPrognostic Value of Positive Presurgical FDG PET/CT in the Evaluation of Tumor-Induced Osteomalacia.
Clinical nuclear medicineBurosumab for the Treatment of Tumor-Induced Osteomalacia.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchOncogenic osteomalacia due to phosphaturic mesenchymal tumour in the upper thoracic spine.
BMJ case reportsClinical Characteristics and Surgical Outcomes of Sinonasal Lesions Associated With Tumor-Induced Osteomalacia.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck SurgeryHypophosphatemia and FGF23 tumor-induced osteomalacia in two cases of metastatic breast cancer.
Clinical nephrologyClinicopathologic and molecular features of six cases of phosphaturic mesenchymal tumor.
Virchows Archiv : an international journal of pathologyAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Bilateral femoral neck fractures and 11 rib fractures unmask tumour-induced osteomalacia caused by a phosphaturic mesenchymal tumour.
- Fibroblast growth factor 23-induced hypophosphatemia in a malignant phosphaturic mesenchymal tumor: presentation of a rare case.
- Tumor-Induced Osteomalacia Mimicking Metastases on Ga-68 DOTATATE Scan: A Rare Pericytic Variant of Phosphaturic Mesenchymal Tumor.
- Skeletal involvement in tumor-induced osteomalacia.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research· 2026· PMID 41092268mais citado
- Phosphaturic Mesenchymal Tumor in the Foot Detected by 99m Tc-FAPI-46 SPECT/CT and 18 F-FDG PET/CT.
- Oncogenic Osteomalacia Due to Tumor in the Femoral Head Managed by Excision and Femoral Head Preservation: A Case Report.
- Diffuse and Prolonged Bone Pain Revealing Tumor-Induced Osteomalacia: A Case Report.
- [Forearm fracture revealing oncogenic osteomalacia].
- Diagnostic Journey in the Recognition of Oncogenic Osteomalacia.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:352540(Orphanet)
- MONDO:0018124(MONDO)
- GARD:9652(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Q7852667(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
