Introdução
O que você precisa saber de cara
Furosemida, vendida sob o nome comercial Lasix, entre outros, é um medicamento diurético de alça usado para tratar edema devido à insuficiência cardíaca, cirrose hepática ou doença renal. A furosemida também pode ser usada para o tratamento da pressão alta. Pode ser administrada por via intravenosa ou oral. Quando administrada por via intravenosa, a furosemida geralmente faz efeito em cinco minutos; quando tomada por via oral, geralmente é metabolizada em uma hora.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 9 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 27 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
1 gene identificado com associação a esta condição. Padrão de herança: Autosomal recessive.
Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Mitochondrion matrix
Hyperuricemia, pulmonary hypertension, renal failure, and alkalosis syndrome
A multisystem disorder characterized by onset in infancy of progressive renal failure leading to electrolyte imbalances, metabolic alkalosis, pulmonary hypertension, hypotonia, and delayed development. Affected individuals are born prematurely.
Variantes genéticas (ClinVar)
57 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
1 via biológica associada aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Síndrome de hiperuricemia – hipertensão pulmonar – falência renal – alcalose
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Pesquisa e ensaios clínicos
Nenhum ensaio clínico registrado para esta condição.
Publicações mais relevantes
Case Report: A classical PSGN case with unusually prominent serosal manifestations and complement patterns that mimicked systemic autoimmune disease-highlighting diagnostic pitfalls and biopsy decision-making.
Post-Streptococcal glomerulonephritis (PSGN) most commonly follows streptococcal infections and presents with classic features such as hematuria, proteinuria, hypertension, and transient renal dysfunction. While renal-limited disease is typical, extrarenal manifestations-particularly serosal involvement-are exceptionally rare in children. We report a rare case of an adolescent who presented with nephritic syndrome marked by hypertension, gross hematuria, proteinuria, and notably, concurrent pleural and pericardial effusions. Laboratory evaluation revealed low serum complement levels (C3 and C4), consistent with immune complex-mediated glomerulonephritis. Extensive infectious and autoimmune workups were unremarkable. The patient was managed conservatively with antihypertensives and diuretics, with complete resolution of symptoms and normalization of renal function and complement levels within four weeks. To our knowledge, serosal involvement (pleural and pericardial effusions) at initial presentation in pediatric PSGN remains extremely rare, with very few documented cases in the literature. This report contributes valuable clinical insight, emphasizing that PSGN can occasionally mimic systemic inflammatory or autoimmune conditions. Early identification and conservative management can prevent overtreatment and improve outcomes. This case underscores an unusual presentation of PSGN with serosal involvement-a manifestation reported only sporadically in literature. Recognition of such rare systemic features is crucial to avoid diagnostic delays or unnecessary immunosuppression. Supportive care alone led to favorable outcomes, reinforcing the self-limited nature of PSGN even in atypical presentations. It serves as a valuable reminder that atypical PSGN can present with multi-system inflammation, and a precise diagnostic approach integrating serology and clinical course is essential to avoid unnecessary intervention.
High-grade follicular B-cell lymphoma-associated C3 rapidly progressive glomerulonephritis: a rare association.
Rapidly progressive glomerulonephritis (GN) in the context of B-cell lymphoma is rare, with most cases involving diffuse-large B-cell lymphoma or marginal zone lymphoma. Kidney biopsies are infrequently performed in this population, further limiting diagnostic clarity. Here, we report a case of newly diagnosed follicular large B-cell lymphoma (FLBCL) presenting with a nephritic syndrome, characterised by haematuria, hypertension and heavy proteinuria, caused by C3 crescentic GN, requiring dialysis. The patient was treated with polatuzumab, bendamustine and rituximab, which was well tolerated. Renal function gradually improved, leading to dialysis discontinuation, coinciding with lymphoma remission. This case underscores the atypical presentation of FLBCL, including renal dysfunction as an early manifestation, and the importance of prompt diagnosis and targeted therapy.
Melatonin as a Redox Modulator in Developmental Programming: Implications for Cardiovascular-Kidney-Metabolic Risk.
Melatonin, a multifunctional hormone with antioxidant, anti-inflammatory, and chronobiotic effects, is essential for a healthy pregnancy and fetal development. In the context of the Developmental Origins of Health and Disease (DOHaD), excessive oxidative stress acts as a key driver of maladaptive fetal programming, increasing lifelong susceptibility to cardiovascular, kidney, and metabolic (CKM) disorders. Importantly, most evidence derives from rodent models, and the protective effects of maternal melatonin supplementation appear partial and model-dependent rather than universal. Experimental studies indicate that maternal melatonin supplementation can prevent programmed hypertension, renal dysfunction, and metabolic derangements by restoring redox homeostasis, influencing epigenetic and nutrient-sensing pathways, and modulating the gut microbiome. Early clinical investigations in pregnancies complicated by preeclampsia or intrauterine growth restriction suggest that melatonin is well tolerated, improves placental function, and benefits neonatal outcomes. However, optimal dosing and long-term safety for offspring remain to be established. This review synthesizes mechanistic and translational evidence, framing melatonin as an integrative biological mediator with potential to guide preventive strategies and mitigate the intergenerational risk of CKM syndrome.
Management of pediatric patients with moyamoya arteriopathy and middle aortic syndrome: a retrospective single-institution case series.
Moyamoya arteriopathy and middle aortic syndrome (MAS) are each rare, often progressive vascular diseases; their comorbid intersection increases their complexity because of the independent and contradictory demands on blood pressure. The management of pediatric patients with these comorbid conditions requires multidisciplinary consultation given the high risk involved. In the current study, the authors aim to describe the clinical and surgical history of pediatric patients with comorbid moyamoya arteriopathy and MAS and describe a multidisciplinary approach to care for these patients. This study is a retrospective review of the clinical and radiological records of patients at Boston Children's Hospital who were treated with cerebral revascularization surgery for comorbid moyamoya arteriopathy and MAS from January 2004 to January 2024. Analysis of collected perioperative, surgical, inpatient, and follow-up data was conducted using R version 4.4.2 (R Foundation for Statistical Computing). Eleven patients, 5 male (45.5%), were included in the study. At presentation, 9 patients (81.8%) had symptoms from brain ischemia. Nine patients were on antihypertensive medications (median 2, IQR 1-2). All patients underwent surgery for moyamoya arteriopathy, and 6 patients (54.5%) also underwent surgical treatment for MAS. After moyamoya surgery, 4 patients (36.4%) required an intensified blood pressure regimen to achieve the same goal, whereas 3 patients (27.3%) had a reduced need for blood pressure medications. Four (66.7%) of the 6 patients who underwent MAS surgical treatment did so after moyamoya treatment. Perioperative stroke occurred after renal stent angioplasty before moyamoya surgery but also after aortic bypass following moyamoya surgery. Managing comorbid moyamoya arteriopathy and MAS is challenging, as patients have a higher risk of ischemic perioperative complications. These patients may have hypertension secondary to their aortic disease, and treating the aortic disease may correct the hypertension but with possible new relative hypotension and relative cerebral hypoperfusion. Consequently, moyamoya revascularization prior to aortic repair may be a strategy to reduce the risk of stroke.
The REDD1-NF-κB-miRNAs-eNOS/SIRT1 axis mediates obesity-induced endothelial cell senescence and hypertension.
Vascular dysfunction, including endothelial cell (EC) senescence and hypertension, is a hallmark of metabolic syndrome, yet its underlying mechanisms remain unclear. Here, we show that metabolic stress upregulates regulated in development and DNA damage response 1 (REDD1), driving vascular dysfunction. Overexpression of REDD1, but not the REDD1KK219/220AA mutant, which cannot activate atypical NF-κB, promotes EC senescence and hypertension through NF-κB-dependent induction of miR-155-5p and miR-214-3p. These miRNAs suppress endothelial nitric oxide synthase (eNOS) and SIRT1 expression in human and mouse ECs. In obese male mice, REDD1 and miR-214-3p are upregulated, whereas eNOS and SIRT1 are downregulated, contributing to EC senescence, renal dysfunction, and hypertension. This phenotype is alleviated in mice lacking Redd1, EC-specific Redd1, or miR-214-3p, and in mice expressing Redd1KK219/220AA, but only partially by IKKβ inhibition. These findings identify a REDD1-atypical NF-κB-miRNAs-eNOS/SIRT1 axis as a critical mediator of obesity-induced vascular dysfunction and a promising therapeutic target.
Publicações recentes
Intestinal obstruction associated with middle aortic syndrome: A case report.
Long-term outcomes after the mesenteric artery growth improves circulation (MAGIC) procedure for midaortic syndrome.
Association of Osteopontin and selective glomerular hypofiltration syndrome with hospitalization for kidney failure in acute heart failure patients.
Identification of cystatin C as a new marker of glomerular filtration rate, and of shrunken pore syndrome - a new kidney disorder defining selective glomerular hypofiltration syndromes - calls for expansion of the international KDIGO guidelines.
Systemic effect of different physiological parameter associated with mirror syndrome.
📚 EuropePMCmostrando 198
Case Report: A classical PSGN case with unusually prominent serosal manifestations and complement patterns that mimicked systemic autoimmune disease-highlighting diagnostic pitfalls and biopsy decision-making.
Frontiers in pediatricsA PROSPECTIVE, OBSERVATIONAL STUDY ON ETIOLOGICAL SPECTRUM OF END STAGE KIDNEY DISEASE IN NORTH INDIA: DOMINANCE OF DIABETIC KIDNEY DISEASE AND EMERGING TRENDS.
Annals of Ibadan postgraduate medicine2026 Latin American consensus for the management of patients with hypertension and cardio-renal and metabolic disturbances: endorsed by the Latin American Society of Hypertension, the Iberoamerican Hypertension League, and the World Hypertension League.
Journal of hypertensionOvarian Hormones Moderate Systolic Hypertension in Female Eln Haploinsufficient Mice.
American journal of physiology. Renal physiologyCase Report: Spontaneous Tumor Lysis Syndrome in a Patient With Cholangiocarcinoma.
Journal of investigative medicine high impact case reportsContinuous monitoring of intra-abdominal pressure: cumulative pressure exposure predicts early acute kidney injury in animal model.
World journal of emergency surgery : WJESHemoglobinuria-associated acute kidney injury in hemolytic uremic syndrome without renal thrombotic microangiopathy.
BMC nephrologyRelapse of Membranous Nephropathy Following Adrenalectomy for Cushing Syndrome: A Case Report.
Internal medicine (Tokyo, Japan)Severe renovascular hypertension in an infant with a SMAD3 gene variant.
Pediatric nephrology (Berlin, Germany)Maternal Morbidity and Complications in Hemolysis, Elevated Liver Enzymes, and Low Platelet Count (HELLP) Syndrome: A Retrospective Case Series.
CureusHigh-grade follicular B-cell lymphoma-associated C3 rapidly progressive glomerulonephritis: a rare association.
BMJ case reportsCross-sectional study exploring the characteristics of hospitalized patients admitted for acute pancreatitis who develop abdominal compartment syndrome in US hospitals.
Proceedings (Baylor University. Medical Center)Rituximab-Associated Posterior Reversible Encephalopathy Syndrome in Severe Hydralazine-Induced Antineutrophil Cytoplasmic Antibody Vasculitis: An Unexpected Complication.
CureusNon-Extremity Thrombosis Sequelae in Children: Screening, Diagnosis, and Management.
Journal of thrombosis and haemostasis : JTHBardet-Biedl syndrome in two sibling pairs: a case series.
Journal of medical case reportsSelenoprotein P Deficiency Is Associated with Early Signs of Kidney Disease and Hospitalization Risk in Heart Failure.
NutrientsMelatonin as a Redox Modulator in Developmental Programming: Implications for Cardiovascular-Kidney-Metabolic Risk.
International journal of molecular sciencesPosterior Reversible Encephalopathy Syndrome in Peritoneal Dialysis Patients: A Four-Case Series.
Journal of clinical medicineManagement of pediatric patients with moyamoya arteriopathy and middle aortic syndrome: a retrospective single-institution case series.
Journal of neurosurgery. PediatricsThe Urgent Need for Cardiometabolic Health Training: A Call to Action.
CureusEfficacy of cilastatin sodium in a translational large animal crush syndrome model.
Communications medicineThe REDD1-NF-κB-miRNAs-eNOS/SIRT1 axis mediates obesity-induced endothelial cell senescence and hypertension.
Nature communicationsIncidence of intra-abdominal hypertension after liver transplantation with temporary portocaval shunt - A prospective cohort.
Clinics (Sao Paulo, Brazil)Chronic Inflammation as an Overlooked Link Between Cardiovascular and Kidney Disease: A Focus on Interleukin-6 and C-Reactive Protein.
Clinical journal of the American Society of Nephrology : CJASNLinezolid-induced Posterior Reversible Encephalopathy Syndrome: A Case Report and Review of the Literature.
Clinical neuropharmacologyRenal artery stenosis in heart failure: the overlooked cardiorenal culprit?
European journal of heart failurePulmonary Artery Denervation for Refractory Sjögren's Syndrome-Associated Pulmonary Arterial Hypertension: A Case Report of Combined Hemodynamic and Renal Recovery.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & InterventionsHeart failure associated with renal artery stenosis and Pickering syndrome: the critical role of endovascular revascularization: a case series and meta-analysis.
Clinical hypertensionHeterozygous X-linked Alport syndrome in a pregnant woman: A case report.
SAGE open medical case reportsPeripheral arterial lesions detected by vascular ultrasound and their association with aortic events in heritable thoracic aortic diseases.
International journal of cardiology. Heart & vasculatureCurrent Trends and Future Perspectives of Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia (BRASH) Syndrome: A Narrative Review.
CureusAbdominal Compartment Syndrome Following Massive Transfusion in Upper Gastrointestinal Bleeding: A Case Report.
CureusA Case of Posterior Reversible Encephalopathy Syndrome With Single-Agent Weekly Paclitaxel.
CureusCardiac Complications in Systemic Lupus Erythematosus: A Systematic Review of Diagnostic and Prognostic Gaps.
CureusSuccessful prosthetic graft replacement for middle aortic syndrome in a 9-year-old child.
Cardiology in the youngDecoding lung-kidney interactions in sepsis: an integrated view of molecular mechanisms, pathophysiology, and therapeutic interventions.
Frontiers in immunology[Screening for albuminuria to assess cardiovascular risk].
Revue medicale suisseDaratumumab for Treatment of Refractory Podocytopathy: A Case Report.
Kidney medicineHorns, nails, and leaky kidneys: A rare case of congenital nephrotic syndrome.
Clinical nephrology. Case studiesDual carrier status for HUPRA (hyperuricemia, pulmonary hypertension, renal failure, and alkalosis) syndrome and Wilson disease in a young dialysis patient: clinical and genetic counseling implications.
Clinical transplantation and researchRenal Venous Hypertension and Kidney Dysfunction: Implications for Clinical Practice.
Cardiology in reviewPosterior Reversible Encephalopathy Syndrome Caused by Renovascular Hypertension in a Solitary Functioning Kidney: Successful Treatment With Renal Artery Stenting.
CureusSex differences in potassium regulation: evidence, molecular mechanisms and clinical implications.
Biology of sex differencesA rare case of ectopic cushing's syndrome caused by renal neuroendocrine tumor.
Journal of diabetes and metabolic disorders[When kidney disease is genetic: clues for the primary care physician].
Revue medicale suisseCurrent Appraisal and Gaps in Knowledge in Cardio-Kidney Metabolic Syndrome Definition.
International journal of molecular sciencesExceptional Response to a Single Dose of Pembrolizumab as Salvage Therapy for Metastatic Adrenocortical Carcinoma.
JCEM case reportsAcute Neurological and Respiratory Complications Induced by Wasp Stings: A Case Report.
The American journal of case reportsRenal Denervation Improves Hepatic Steatosis in Hypertensive Patients With Metabolic Syndrome.
Hypertension (Dallas, Tex. : 1979)Bradycardia, Renal Dysfunction, Atrioventricular Node Blockade, Shock, and Hyperkalemia (BRASH) Syndrome: Clinical Features, Outcomes, and Therapeutic Implications.
CureusUrinary dopamine, sodium handling, and blood pressure in a bi-ethnic South African population: the SABPA study.
Cardiovascular journal of AfricaPosterior reversible encephalopathy syndrome (PRES): A narrative review of pathophysiology, clinical insights, and advances in management.
International journal of emergency medicineOutcomes and predictors of kidney failure in elderly patients with biopsy-proven IgA nephropathy.
Renal failureTerlipressin in paediatric hepatorenal syndrome-acute kidney injury (HRS-AKI).
Pediatric nephrology (Berlin, Germany)A Silent Obstruction: Ureteropelvic Junction Syndrome Presenting As Resistant Hypertension in an Adult.
CureusHerbal medicine use and renal dysfunction among persons living with HIV on Tenofovir-based ART in Kampala, Uganda.
PloS oneSonographic Hallmarks of Nutcracker Syndrome.
Ultrasound quarterlyNeutrophil Gelatinase-Associated Lipocalin Drives Cardiac Remodeling in Rats With Chronic Kidney Disease.
Hypertension (Dallas, Tex. : 1979)A Case of Posterior Reversible Encephalopathy Syndrome Complicating a Thoracic Spinal Subdural Hematoma.
CureusTesticular vein syndrome: hydronephrosis secondary to ureteral compression-a case report.
Journal of medical case reportsAn unusual trilogy: a case of comorbid aHUS, Fabry disease, and hypertrophic cardiomyopathy.
Frontiers in medicineSevere Hypokalemia After Corticosteroid Use: A Case of Steroid-Induced Potassium Depletion.
CureusClinicopathologic Features and Prognostic Factors in Biopsy-Confirmed Renal Involvement in Primary Sjőgren's Syndrome.
Kidney360Early eculizumab treatment improves renal outcomes in pediatric lupus nephritis with thrombotic microangiopathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal AssociationOne-Year Follow-Up of Red Yeast Rice-Associated Renal Dysfunction: A Report of Two Cases.
CureusAssociation between metabolic dysfunction-associated fatty liver disease and cardiovascular autonomic neuropathy in type 2 diabetes.
Frontiers in endocrinologyGenetic Syndromes and Multimorbidity in Adults with Congenital Heart Disease and Heart Failure: Insights from the PATHFINDER-CHD Registry.
Journal of clinical medicineC3 mutation-associated atypical hemolytic uremic syndrome with severe renal dysfunction and hypertensive emergency successfully treated with ravulizumab and sacubitril/valsartan: a case report.
BMC nephrologyFSTIV score is essential for clinical management and predicts outcome of idiopathic membranous nephropathy.
BMC nephrologyC3 molecular structural and histopathological analyses in a pediatric case of atypical hemolytic uremic syndrome with life-threatening gastrointestinal bleeding-a case report.
Frontiers in pediatricsCausal demonstration of adiposity-induced adipose-specific signaling derangements in the pathogenesis of the clinical features of the cardiovascular-kidney metabolic syndrome.
Cardiovascular diabetologyHypertensive Havoc: When Malignant Hypertension Mimics Thrombotic Thrombocytopenic Purpura.
CureusBlood pressure variability and frailty: mechanisms, evidence, and clinical implications.
International urology and nephrologyDialysis disequilibrium syndrome: An overview of the current neurosurgical state.
Surgical neurology internationalGlomerular Transcriptome Analysis Reveals Endothelial Disturbances in Patients With Idiopathic Nephrotic Syndrome.
Kidney medicineResistant Hypertension: Integration of Novel Agents and Interventional Approaches in Clinical Practice.
Reviews in cardiovascular medicineWhy is the European Unifying Recommendation for Treating Syndrome of Inappropriate Antidiuretic Hormone (SIADH) and Cerebral Renal Salt Wasting Not Commonly Recommended in the US.
CureusCase Report: Neuroretinitis versus hypertensive retinopathy secondary to Alport syndrome.
Frontiers in neurologyTargeting GLP1 receptor for reducing global cardiovascular risk.
Journal of translational medicineThe impact of acute coronary syndrome on long-term survival in cancer patients.
Cardio-oncology (London, England)The hidden burden of kidney damage in chylomicronemia syndromes.
AtherosclerosisST-segment elevation myocardial infarction as the first clue to membranous nephropathy: A case report.
MedicineEnamel renal syndrome due to FAM20A mutations: challenging kidney management in view of nephrocalcinosis, hypophosphatemia and hypocalciuria.
Orphanet journal of rare diseasesSevere Arterial Thrombosis Revealing Underlying Nephrotic Syndrome.
CureusIntestinal obstruction associated with middle aortic syndrome: A case report.
The Journal of international medical researchClinical manifestations of primary aldosteronism and cardiometabolic risk.
Vitamins and hormonesAcute kidney injury requiring temporary hemodialysis due to HELLP syndrome: a case report.
CEN case reportsEndovascular Management of Renal Arteriovenous Fistula Associated with Nutcracker Syndrome.
EJVES vascular forumPersistent Hypercalcemia: Diagnostic Complexity With Multiglandular Hyperparathyroidism, Renal Cell Carcinoma, and Hereditary Tumor Features.
CureusAlways Consider a Repeat Kidney Biopsy: Acute Interstitial Nephritis Soon After Membranous Nephropathy.
Case reports in nephrologyCellular Interactions and Immunometabolic Mechanisms in Heart Failure With Preserved Ejection Fraction: From Molecular Mechanisms to Clinical Evidence.
Circulation. Heart failureAcute kidney injury is a major mediator of intra-abdominal pressure-related mortality in critically ill patients: a longitudinal analysis.
Journal of anesthesia, analgesia and critical careHistopathological evaluation in post-mortem renal biopsies of patients with COVID-19 and comorbidities: a case-control study.
Sao Paulo medical journal = Revista paulista de medicinaA Review of the Long-Term Cardiovascular Consequences of Hypertensive Disorders of Pregnancy.
CureusCutting Balloon Angioplasty for Resistant Pediatric Renal Artery Stenosis: A Single Institutional Experience.
Journal of vascular and interventional radiology : JVIRAtypical Presentation of a Preeclamptic Patient With Severe Features and Auditory Hallucinations.
CureusCardiovascular-kidney-metabolic syndrome in Indonesia: a commentary on the need for integrated management and policy action.
Frontiers in public healthSuccessful term pregnancy after renal transplant in end-stage renal disease with complement factor H-related mutation: A case report.
World journal of transplantationPopulation developmental hazard of over-the-counter NSAIDs.
Folia medica CracoviensiaLong-Term Kidney Outcomes After SARS-CoV-2 Infection in Children Aged 0-12 Years: A Systematic Review.
Children (Basel, Switzerland)SIADH as an Underrecognized Manifestation of Porphyria-like Crises in Hereditary Tyrosinemia Type 1: Clinical and Pathophysiological Insights.
International journal of molecular sciencesComparison of the Clinical Course, Management and Outcomes of Acute Pancreatitis in Aged and Young Patients.
BiomedicinesSystemic Arterial Stiffness in Reversible Cerebral Vasoconstriction Syndrome: A Prospective Case-Control Study.
European journal of neurology[Comparison of outcomes between emergency surgery and conservative treatment for acute type A aortic intramural hematoma].
Zhonghua yi xue za zhiSequential Bilateral Central Retinal Vein Occlusion With Differential Long-Term Outcomes Following Cardiac Surgery.
CureusJAG1 of all trades, master of CKD? The role of JAG1 in autosomal dominant tubulointerstitial kidney disease.
Kidney internationalVascular Non-Inflammatory Molecule-1 Aggravates Acute Kidney Injury Induced Acute Lung Injury Via Promoting Neutrophil Extracellular Traps Formation.
InflammationFrailty in Focus: A Scoping Review of Frailty Instruments from the Kidney Disease Aging Research Collaborative.
Clinical journal of the American Society of Nephrology : CJASNTubulointerstitial nephritis with uveitis (TINU) syndrome following COVID-19 vaccination in an elderly patient: a case report.
CEN case reportsSevere Maternal Morbidity and Long-Term Kidney Outcomes among Pregnant Women Receiving Maintenance Dialysis.
Journal of the American Society of Nephrology : JASNModulation of the Apolipoprotein M/S1PR4 Pathway Reduces Podocyte Lipid Overload in Alport Syndrome via Distinct Autophagy and Efflux Mechanisms.
Journal of the American Society of Nephrology : JASNImpact of metabolic syndrome and its components on the tumor aggressiveness of renal cell carcinoma.
MedicineThe Hepato-Cardio-Renal Axis in Cirrhosis: Hemodynamic and Mechanistic Insights, Diagnostic Biomarkers, and Expanding Therapeutic Horizons.
Discoveries (Craiova, Romania)Neural Upregulation of SGLT2-MAP17-PDZK1 Complex in Kidneys of Rats With Heart Failure.
Hypertension (Dallas, Tex. : 1979)SGLT2 inhibitors are associated with improved long-term survival in Takotsubo syndrome: insights from large-scale real-world data.
European heart journal. Cardiovascular pharmacotherapyGDF-15 as an integrative cardiometabolic biomarker.
Clinica chimica acta; international journal of clinical chemistryEpidemiology of Macrovascular and Microvascular Complications Among Patients With Diabetes Mellitus in Primary Care in Bahrain.
CureusExtracorporeal membrane oxygenation for pulmonary arterial hypertension complicating pregnancy: case series and literature review.
BMC pregnancy and childbirthEndothelial cell-released CD93 contributes to podocyte injury in idiopathic nephrotic syndrome.
Science translational medicineAlport Syndrome is a Partial Tubulointerstitial Disease of the Kidney.
Kidney international reportsCorrelation between albumin-bilirubin score and comorbidity of cardiovascular disease and chronic kidney disease: insights from NHANES 2011-2018.
European journal of medical researchRare systemic artery lesions due to Kawasaki disease diagnosed in adults: a review of the literature on abdominal aortic aneurysms and renovascular hypertension.
Cardiology in the youngUnmasking malnutrition through soluble RAGE: A biomarker-guided insight from FRASNET.
Experimental gerontologyA Tale of Two Syndromes: The Temptation of Expanded Inclusivity in Cardiorenal Medicine.
Kidney360The Beneficial Effects of Glucagon-Like Peptide-1 Agonists on Blood Pressure: A Comprehensive Review.
Reviews in cardiovascular medicineGas chromatography-mass spectrometry-based plasma metabolomics analysis in hypertensive patients with Yin deficiency and Yang hyperactivity syndrome.
World journal of experimental medicineCoronary Artery Vasospasm Presenting as Non-ST Segment Elevation Myocardial Infarction in a Nigerian Female: A Case Report.
CureusThe 2025 KDIGO guideline on the management of nephrotic syndrome in children: a comment of the European Renal Association Immunonephrology Working Group.
Clinical kidney journalTwenty years of pediatric vascular surgery consultations and interventions at a tertiary academic center.
Journal of vascular surgeryFeasibility and Early and Midterm Outcomes of Midaortic Syndrome: A Retrospective Cohort Study.
Journal of clinical medicineMultiorgan involvement and residual effects in transurethral resection of prostate syndrome: A case report and literature review.
Urology case reportsExplainable machine learning framework using visceral adiposity index to predict cardiorenal syndrome: a survey-weighted NHANES study with SHAP interpretation.
Renal failureIncidental Finding of Secondary Focal Segmental Glomerulosclerosis in Renal Allograft due to Renal Artery Stenosis.
Pediatric transplantationDiagnostic Challenges in Atypical Hemolytic Uremic Syndrome: A Case of Artificial Mitral Valve Dysfunction as a Possible Trigger for Severe Thrombotic Microangiopathy.
The American journal of case reportsSecondary causes and renal outcomes in apparently resistant hypertension: a retrospective cohort study.
Blood pressureOsmotic Nephropathy Induced by L-Proline Stabilized Sucrose-free Intravenous Immunoglobulins: A Case Report.
Kidney medicineComplicated Pregnancy in a Patient with Distal Renal Tubular Acidosis, Systemic Lupus Erythematosus, and Antiphospholipid Syndrome: A Rare Case and Management Strategies.
Acta medica IndonesianaPetting Zoo Perils: Escherichia coli O157:h7 Associated Hemolytic Uremic Syndrome Secondary to Animal Exposure.
Hemodialysis international. International Symposium on Home HemodialysisPosterior reversible encephalopathy syndrome following blood transfusion and GnRH agonist.
Practical neurologyWhy are SGLT2 inhibitors effective in HFpEF? Implications for interstitial fluid retention and cardio-renal interaction.
Hypertension research : official journal of the Japanese Society of HypertensionSilent progression: cardiac amyloidosis unmasking IgG lambda myeloma in an elderly patient.
The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of CardiologyA rare case of apparent mineralocorticoid excess induced by chronic liquorice ingestion.
Endocrinology, diabetes & metabolism case reportsTandem Extracorporeal Blood Purification/Support Therapies in Critically Ill Children: A Literature Review.
Critical care medicineDual-Genetic Etiology in an Atypical Dent Disease Phenotype Which Combines Features of Focal Segmental Glomerulosclerosis and Ellis-Van Creveld-Like Syndrome: A Case Report.
Case reports in nephrology and dialysisHypokalemic metabolic alkalosis as a clinical clue to ectopic ACTH syndrome: two cases of neuroendocrine carcinoma.
Endocrine regulationsAssociation of cardiovascular-kidney-metabolic syndrome stages with mortality: A nationwide, population-based, prospective cohort study.
Chinese medical journalParadoxical Hyperkalemia in Bartter Syndrome: A Case Report of Severe Resistant Hyperkalemia Requiring Hemodialysis.
Case reports in nephrologyComplement factor H-point mutation promotes the development of preeclampsia-like phenotype with multiparity in mice.
PlacentaFactors associated with venous and arterial thrombosis in patients with Systemic Lupus Erythematosus: A systematic review and meta-analysis.
Thrombosis researchBeyond CKD-Associated Pruritus: Paraneoplastic Itch Revealing CLL/SLL in ESRD: A Case Report.
The American journal of case reportsEmerging methods for subtype differentiation in primary aldosteronism.
Journal of internal medicineFlash Pulmonary Oedema in a Patient With Unilateral Renal Artery Stenosis and Preserved Contralateral Function: A Medically Managed Case Report.
CureusReverse-Wire TEVAR for Subacute Type B Aortic Dissection with Severe True-Lumen Collapse: A Case Report.
Life (Basel, Switzerland)SGLT2 Inhibitors and Liver Cirrhosis: Hype or Hope?
Life (Basel, Switzerland)Mitochondrial tRNA-Derived Diseases.
International journal of molecular sciencesTemporary Portocaval Shunts During Liver Transplantation: A Narrative Review of Technical Solutions and Post-Transplant Outcomes.
Journal of clinical medicineFirst-Line Treatment with Tivozanib for Metastatic Renal Cell Carcinoma in Real-World Settings Across Germany: Results of the Prospective, Non-Interventional, Post-Approval Study T-Rex.
CancersChemerin as a Mediator of Hypertension and Cardiometabolic Diseases (A Comprehensive Review).
Current hypertension reportsExploring the association between pulse wave velocity and CKD progression: a longitudinal study in Mashhad, Iran.
Scientific reportsNephrotic syndrome genomic discovery in the Mass General Brigham Biobank identifies monoallelic MEFV variants as a risk factor for focal segmental glomerulosclerosis.
Kidney internationalPendrin is upregulated by corticosterone and participates in its pressor response.
American journal of physiology. Renal physiologyBeyond Traditional Risk Factors: Inflammation, Asymmetric Dimethylarginine, and N-Terminal pro-B-Type Natriuretic Peptide Predict Cardiovascular Risk in Chronic Kidney Disease.
CureusIntegrated mechanisms linking sodium-potassium imbalance to salt-sensitive hypertension.
Physiological reportsHuman coronavirus HKU1 (HCoV-HKU1)-associated acute respiratory distress syndrome: A case report.
Respiratory medicine case reportsPrimary aldosteronism: adrenalectomy could save more lives.
Frontiers in endocrinologyAnti-PLA2R Antibody-Positive Membranous Nephropathy Superimposed by Pleural Tuberculosis a Year Later: Mere Association or Actual Cause?
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia[The Characteristics of Course of Pregnancy and Perinatal Outcomes in Women with Gestation Diabetes Mellitus (The Results of Ten-Years Research)].
Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsinyLong-Term Renal Outcomes Among COVID-19 ICU Survivors Admitted With Acute Kidney Injury.
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Scientific reportsUltrasound-Guided Jugular Vein Access for Inferior Petrosal Sinus Sampling: A Safe and Feasible Technique.
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Case Report: A classical PSGN case with unusually prominent serosal manifestations and complement patterns that mimicked systemic autoimmune disease-highlighting diagnostic pitfalls and biopsy decision-making.
- High-grade follicular B-cell lymphoma-associated C3 rapidly progressive glomerulonephritis: a rare association.
- Melatonin as a Redox Modulator in Developmental Programming: Implications for Cardiovascular-Kidney-Metabolic Risk.
- Management of pediatric patients with moyamoya arteriopathy and middle aortic syndrome: a retrospective single-institution case series.
- The REDD1-NF-κB-miRNAs-eNOS/SIRT1 axis mediates obesity-induced endothelial cell senescence and hypertension.
- Intestinal obstruction associated with middle aortic syndrome: A case report.
- Long-term outcomes after the mesenteric artery growth improves circulation (MAGIC) procedure for midaortic syndrome.
- Association of Osteopontin and selective glomerular hypofiltration syndrome with hospitalization for kidney failure in acute heart failure patients.
- Identification of cystatin C as a new marker of glomerular filtration rate, and of shrunken pore syndrome - a new kidney disorder defining selective glomerular hypofiltration syndromes - calls for expansion of the international KDIGO guidelines.
- Systemic effect of different physiological parameter associated with mirror syndrome.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:363694(Orphanet)
- OMIM OMIM:613845(OMIM)
- MONDO:0013458(MONDO)
- GARD:17569(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q30314091(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar