Raras
Buscar doenças, sintomas, genes...
Doença Kikuchi-Fujimoto
ORPHA:50918CID-10 · I88.1CID-11 · 4B2YDOENÇA RARA

A Doença de Kikuchi-Fujimoto (DKF) é uma condição benigna que se resolve sozinha, caracterizada por ínguas inchadas e dolorosas no pescoço, geralmente acompanhada de febre baixa e suores noturnos. Sintomas menos comuns incluem perda de peso, enjoo, vômito e dor de garganta.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

A Doença de Kikuchi-Fujimoto (DKF) é uma condição benigna que se resolve sozinha, caracterizada por ínguas inchadas e dolorosas no pescoço, geralmente acompanhada de febre baixa e suores noturnos. Sintomas menos comuns incluem perda de peso, enjoo, vômito e dor de garganta.

Publicações científicas
770 artigos
Último publicado: 2026 Apr 14

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Casos conhecidos
1.052
pacientes catalogados
Início
Adolescent
+ adult, childhood, infancy
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: I88.1
Você se identifica com essa condição?
O Raras está aqui pra te apoiar — com ou sem diagnóstico

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🧬
Pele e cabelo
9 sintomas
🩸
Sangue
8 sintomas
🫃
Digestivo
4 sintomas
📏
Crescimento
2 sintomas
❤️
Coração
1 sintomas
🧠
Neurológico
1 sintomas

+ 22 sintomas em outras categorias

Características mais comuns

90%prev.
Linfadenopatia cervical
Muito frequente (99-80%)
55%prev.
Anorexia
Frequente (79-30%)
55%prev.
Calafrios
Frequente (79-30%)
55%prev.
Nódulo cutâneo
Frequente (79-30%)
55%prev.
Vasculite
Frequente (79-30%)
55%prev.
Edema palpebral
Frequente (79-30%)
50sintomas
Muito frequente (1)
Frequente (21)
Ocasional (22)
Muito raro (6)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 50 características clínicas mais associadas, ordenadas por frequência.

Linfadenopatia cervicalCervical lymphadenopathy
Muito frequente (99-80%)90%
Anorexia
Frequente (79-30%)55%
CalafriosChills
Frequente (79-30%)55%
Nódulo cutâneoSkin nodule
Frequente (79-30%)55%
VasculiteVasculitis
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico770PubMed
Últimos 10 anos200publicações
Pico202556 papers
Linha do tempo
2026Hoje · 2026🧪 2010Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
·Pré-clínico1
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 1 ensaio
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Doença Kikuchi-Fujimoto

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

2 ensaios clínicos encontrados.

Distribuição por fase
Ver todos no ClinicalTrials.gov
🧪 Está conduzindo uma pesquisa?
Divulgue para pacientes e familiares que acompanham esta doença.
Divulgar pesquisa →

Publicações mais relevantes

Timeline de publicações
450 papers (10 anos)
#1

Co-occurrence of disseminated Mycobacterium kansasii infection and Kikuchi-Fujimoto disease in an immunocompetent patient.

BMJ case reports2026 Jan 07

Disseminated Mycobacterium kansasii infection and Kikuchi-Fujimoto disease (KFD) are rare and diagnostically challenging conditions, especially when they occur together. They present with similar symptoms such as lymphadenopathy, prolonged fever and weight loss, which often lead to misdiagnoses. This case report describes the uncommon co-occurrence of disseminated M. kansasii infection and KFD in a young female patient who experienced a prolonged, intermittent high-grade fever, weight loss and lymphadenopathy. A lymph node biopsy showed features typical of KFD, while mycobacterial culture detected M. kansasii She responded well to tailored non-tuberculous mycobacterial therapy, with clinical and radiological improvement. This case underscores the need to consider concurrent infections in patients presenting with KFD-like symptoms. It also contributes to the small body of literature on the co-occurrence of these two conditions.

#2

Kikuchi-Fujimoto disease following the subacute phase of Kawasaki disease.

Pediatrics international : official journal of the Japan Pediatric Society2026
#3

Kikuchi-Fujimoto disease presenting as the initial symptom of erythema multiforme.

Pediatrics and neonatology2026 Jan
#4

An abnormal immune response masquerading as infectious conditions.

SAGE open medical case reports2026

Kikuchi-Fujimoto disease (KFD) is a rare, benign, self-limited lymphadenitis most commonly affecting children and young adults, particularly females of Asian descent. Its etiology is unclear but is thought to involve immune dysregulation triggered by infection. We report a 14-year-old South Asian female presenting with 8 days of high fever, frontal headache, bilateral eye redness, transient arthralgias, and palpable lymphadenopathy in the cervical, axillary, and supraclavicular regions. Her history included recent travel to multiple countries and a prior episode of fever of unknown origin attributed to Bartonella. Initial laboratory evaluation revealed pancytopenia, elevated transaminases, and increased erythrocyte sedimentation rate and lactate dehydrogenase with normal C reactive protein. Infectious workup was negative for malaria, cytomegalovirus, West Nile virus, Rickettsia, Bartonella, and dengue. Ultrasound of the left axilla and computed tomography showed bilateral axillary lymphadenopathy. A cytokine panel demonstrated markedly elevated IL-18. Definitive diagnosis was established by axillary lymph node biopsy, which revealed histiocytic necrotizing lymphadenitis consistent with KFD. Systemic inflammatory disorders such as systemic-onset juvenile idiopathic arthritis, multisystem inflammatory syndrome in children, and Kawasaki disease were considered and excluded based on clinical, laboratory, and histopathological findings. The patient's fever resolved after dexamethasone administration, supporting an immune-mediated process. She subsequently developed recurrent fever, rash, and oral ulcers, which responded rapidly to intravenous corticosteroids, followed by a steroid taper.

#5

Localised Kikuchi-Fujimoto Disease With Mediastinal Lymphadenopathy: A Case Initially Mimicking Malignant Lymphoma on Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration Cytology.

Respirology case reports2026 Feb

Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotising lymphadenitis, is a benign, self-limiting disorder that primarily affects young women and is typically characterised by fever and cervical lymphadenopathy. However, isolated mediastinal lymphadenopathy without cervical involvement is rare. We report the case of a 37-year-old woman who presented with persistent fever and mediastinal lymphadenopathy. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) cytology of the lymph nodes revealed necrosis and atypical lymphoid cells, highly suggestive of malignant lymphoma. Owing to diagnostic difficulties, video-assisted thoracoscopic excision was performed to obtain a definitive diagnosis. Histopathological examination confirmed KFD with massive necrosis and histiocytic infiltration. The patient underwent symptomatic treatment and remained under long-term follow-up. This case highlights the rarity of mediastinal-limited KFD and the diagnostic pitfall of EBUS-TBNA cytology, emphasising that surgical biopsy is critical for an accurate diagnosis when malignancy is suspected in this atypical presentation.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC650 artigos no totalmostrando 197

2026

An abnormal immune response masquerading as infectious conditions.

SAGE open medical case reports
2026

Localised Kikuchi-Fujimoto Disease With Mediastinal Lymphadenopathy: A Case Initially Mimicking Malignant Lymphoma on Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration Cytology.

Respirology case reports
2026

Negative Correlation Between Serum Ferritin and CD4+ Lymphocytes: A Retrospective Study on Kikuchi-Fujimoto Disease.

Immunity, inflammation and disease
2026

Novel Clinical and Histological Insights into Cutaneous Kikuchi-Fujimoto Disease and Kikuchi Disease-Like Inflammatory Pattern (KLIP).

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
2026

Kikuchi-Fujimoto Disease and Hemophagocytic Lymphohistiocytosis: A Rare Combination of Two Rare Diseases.

Mediterranean journal of hematology and infectious diseases
2025

Late progression of pediatric Kikuchi-Fujimoto disease to systemic lupus erythematosus: a case report and review of literature.

Frontiers in immunology
2026

[Diagnostic challenges in pediatric lymphomas].

Pathologie (Heidelberg, Germany)
2026

Kikuchi-Fujimoto disease following the subacute phase of Kawasaki disease.

Pediatrics international : official journal of the Japan Pediatric Society
2026

Kikuchi-Fujimoto Disease as the Initial Presentation of Dermatomyositis.

Current rheumatology reviews
2025

Adult-Onset Still's Disease Presenting with Atypical Kikuchi-Fujimoto Disease-Like Histiocytic Necrotizing Lymphadenitis: A Diagnostic Pitfall.

European journal of case reports in internal medicine
2026

Co-occurrence of disseminated Mycobacterium kansasii infection and Kikuchi-Fujimoto disease in an immunocompetent patient.

BMJ case reports
2026

Tuberculosis presenting with necrotic retroperitoneal lymphadenopathy in an immunocompetent patient: A case report and literature review.

IDCases
2025

Nocardia farcinica as a potential pathogen associated with a clinical subtype of Kikuchi-Fujimoto disease.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2025

A Rare Differential for Myalgia and Fever Associated With Cervical and Axillary Lymphadenopathy Presenting via Same Day Emergency Care.

Cureus
2026

Kikuchi-Fujimoto disease presenting as the initial symptom of erythema multiforme.

Pediatrics and neonatology
2025

Acute myocardial infarction in an adolescent following recurrent Kikuchi-Fujimoto disease.

BMJ case reports
2025

The immunological impostor: Kikuchi-Fujimoto disease vs systemic lupus erythematosus.

The New Zealand medical journal
2025

Kikuchi-Fujimoto disease misdiagnosed as tubercular lymphadenitis: A puzzle in cervical lymph nodes.

Journal of family medicine and primary care
2025

Kikuchi-Fujimoto Disease: A Rare Etiology Behind Pediatric Cervical and Supraclavicular Lymphadenopathy: A Case Report.

Reports (MDPI)
2026

Fever of Unknown Origin and Mesenteric Lymphadenitis in a Child: A Diagnostic Challenge Between Tuberculosis, Lymphoma, and Kikuchi-Fujimoto Disease.

The Pediatric infectious disease journal
2025

Laboratory diagnosis of 44 cases of pediatric histiocytic necrotizing lymphadenitis.

Frontiers in pediatrics
2025

A Rare Case of Kikuchi-Fujimoto Disease Complicated with Hemophagocytic Lymphohistiocytosis.

Clinical laboratory
2025

[Kikuchi-Fujimoto disease: case report of a 32-year-old woman with lymphadenopathy and fever].

Zeitschrift fur Rheumatologie
2025

Systemic Lupus Erythematosus Developing in a Young African Female Patient With Kikuchi-Fujimoto Disease.

Cureus
2025

Generalized Lymphadenopathy in a Young Boy: A Rare Presentation of Kikuchi-Fujimoto Disease.

Annals of African medicine
2025

Rare in the rare: Kikuchi-Fujimoto disease associated with connective tissue disorders. A report of our experience.

Reumatismo
2025

Diagnosis of Kikuchi-Fujimoto Disease Based on Ultrasound and Clinical Findings.

Lymphology
2025

The Kabuki Syndrome in 18 F-FDG-PET/CT.

Clinical nuclear medicine
2025

Case(s) Report: Clinical, Laboratory, and Histopathological Profile of Kikuchi-Fujimoto Disease in Young Adults.

International journal of rheumatic diseases
2025

Brainstem Encephalitis as an Atypical Neurologic Complication Following Kikuchi-Fujimoto Disease.

Case reports in neurological medicine
2025

Fever of Unknown Origin in Children: A 14-Year, Single Institution Retrospective Review.

Sage open pediatrics
2025

Kikuchi-Fujimoto in the light of the COVID-19: infection and vaccination. A systematic review.

Clinical rheumatology
2025

Clinical characteristics and risk factors for recurrence of Kikuchi-Fujimoto disease in children: a case-control study.

BMC pediatrics
2025

Kikuchi-Fujimoto disease and Behcet's disease: A rare association.

Indian journal of dermatology, venereology and leprology
2025

Case Report: Two Cases of Kikuchi Disease in West Texas With Non-Self-Limited Disease.

Journal of investigative medicine high impact case reports
2025

A case report of Kikuchi-Fujimoto disease initially presented as aseptic meningitis.

Medicina clinica
2025

A Case of Necrotizing Lymphadenitis From Streptococcus pyogenes.

Cureus
2025

A Kikuchi-Fujimoto syndrome in the pocket of a non-Hodgkin lymphoma: case report with a mini-review of the literature.

Annals of medicine and surgery (2012)
2025

Cytological Features of Kikuchi-Fujimoto Disease: A Multicenter Study of 30 Cases.

Cureus
2025

Kikuchi-Fujimoto Disease: A Rare Condition Mimicking Sepsis.

Iranian journal of otorhinolaryngology
2025

Aseptic Meningitis with Cerebellitis Secondary to Histiocytic Necrotizing Lymphadenitis (Kikuchi-Fujimoto Disease): A Case Report.

Acta neurologica Taiwanica
2025

Nodal Mature Plasmacytoid Dendritic Cell Proliferation in a Patient With Chronic Myelomonocytic Leukemia: A Diagnostic Mimic of Blastic Plasmacytoid Dendritic Cell Neoplasm.

Journal of investigative medicine high impact case reports
2025

Kikuchi-Fujimoto disease presenting with prolonged fever and aseptic meningitis in a child: a case report.

Frontiers in pediatrics
2025

A Case Report of Lupus Cerebritis in a Female With Preceding Kikuchi-Fujimoto Disease.

Cureus
2025

Painless postauricular mass: An atypical presentation of Kikuchi-Fujimoto disease.

The Journal of international medical research
2025

Human papilloma virus vaccine induced Kikuchi-Fujimoto disease: A case report.

Lung India : official organ of Indian Chest Society
2025

Kikuchi-Fujimoto disease: a differential for fevers and lymphadenopathy.

BMJ case reports
2025

Kikuchi-Fujimoto disease concurrent with aseptic meningitis or encephalitis in children: a case-control study.

BMC pediatrics
2025

Kikuchi-Fujimoto disease: an unusual case report of lymphadenopathy with the absence of classic symptoms.

Annals of medicine and surgery (2012)
2025

Atypical Presentation of Kikuchi-Fujimoto Disease: Diagnostic Challenges in a Case of Persistent Cervical Lymphadenopathy with Acute Onset Quadriplegia.

Open access emergency medicine : OAEM
2025

Kikuchi-Fujimoto disease, case report.

Oxford medical case reports
2025

Recurrence of Histiocytic Necrotizing Lymphadenitis in Children: A 10-year Multicenter Retrospective Study.

Journal of inflammation research
2025

Diagnostic challenges and management of kikuchi-fujimoto disease: a rare case report.

Annals of medicine and surgery (2012)
2025

Kikuchi Disease in a Young Woman With Sickle Cell Disease: A Case Report.

Cureus
2025

Emergency admission with unremitting fever and lymphadenopathy: Kikuchi-Fujimoto disease causing haemophagocytic lymphohistiocytosis.

BMJ case reports
2025

Symptom-based Kikuchi disease subtypes: Clinical scenarios across specialties in Taiwan with temporal trends analysis.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
2025

Neurological manifestations and complications of Kikuchi-Fujimoto disease: A comprehensive systematic review.

Clinical neurology and neurosurgery
2025

Pediatric Kikuchi-Fujimoto Disease: Case Report and Review of Cutaneous and Histopathologic Features in Childhood.

Dermatopathology (Basel, Switzerland)
2025

Kikuchi-Fujimoto disease: investigating comprehensive clinicopathological features and risk factors for recurrence.

Histopathology
2025

Perforin-2 is overexpressed in Kikuchi-Fujimoto disease.

Virchows Archiv : an international journal of pathology
2024

Case report: Kikuchi-Fujimoto disease presenting with persistent fever and widespread lymphadenopathy in a young adult.

Frontiers in immunology
2025

Serum Alkaline Phosphatase Levels in Pediatric Kikuchi-Fujimoto Disease: A Retrospective Observational Analysis.

Immunity, inflammation and disease
2025

Kikuchi-Fujimoto disease: 6 years old boy rare case in Syria.

Oxford medical case reports
2025

Kikuchi-Fujimoto disease associated optic neuropathy in an adolescent.

American journal of ophthalmology case reports
2024

Pyrexia With Pancytopenia: An Uncommon Presentation of Kikuchi Disease.

Cureus
2024

Unravelling Kikuchi-Fujimoto Disease: A Unique Presentation of Recurrent Aseptic Meningitis in a District Hospital Setting.

Cureus
2025

Acquired autoinflammatory disorders: a dermatologist's perspective.

Clinical and experimental dermatology
2024

Overlap of Adult-Onset Still Disease and Kikuchi-Fujimoto Disease: A Case Report and Literature Review.

Cureus
2024

Kikuchi-Fujimoto Disease With Isolated Mediastinal Lymphadenopathy: A Rare Presentation of an Even Rarer Disease.

Cureus
2024

Case Report of Asymptomatic Kikuchi-Fujimoto Disease.

Current medical imaging
2024

Kikuchi-Fujimoto Disease: A Case Series and Review of the Literature.

Diseases (Basel, Switzerland)
2024

Retrospective Analysis of Aseptic Meningitis in Kikuchi-Fujimoto Disease.

Journal of inflammation research
2024

UNVEILING A RARE CASE OF KIKUCHI-FUJIMOTO IN SINDH, PAKISTAN.

Journal of Ayub Medical College, Abbottabad : JAMC
2024

Spectrum of Kikuchi-Fujimoto Disease: A 10-Year Study in a Tertiary Care Centre in South India.

Cureus
2024

Kikuchi-Fujimoto Disease in posterior mediastinum: A case report.

Asian journal of surgery
2025

Kikuchi-Fujimoto Disease Presenting as Autoimmune Limbic Encephalitis: A Case Report with Review of Literature.

Annals of Indian Academy of Neurology
2024

Exploring an Uncommon Presentation of Kikuchi-Fujimoto Disease: Case Insights.

Cureus
2025

Kikuchi-Fujimoto disease and primary Sjögren's syndrome coexisting: A case-based literature review.

Modern rheumatology case reports
2024

When Rare Meets Reality: A Case of Kikuchi-Fujimoto Disease in Tertiary Care Center.

Cureus
2025

Kikuchi-Fujimoto disease co-occuring with Hashimoto thyroiditis: A case report and literature review.

Annals of clinical biochemistry
2024

Kikuchi-Fujimoto - an enigmatic and rare disease: a report of 3 cases and brief review of the literature.

ARP rheumatology
2024

Recurrence of Kikuchi-Fujimoto Disease following influenza vaccination, diagnosis aided using ultrasound examination.

Rheumatology advances in practice
2024

Behcet's Disease Presenting as Pancolonic Ulcerations in a Patient With Kikuchi-Fujimoto Disease: A Rare Gastrointestinal Manifestation.

ACG case reports journal
2024

Kikuchi-Fujimoto disease: rare but worth remembering.

Polish archives of internal medicine
2024

Could Kikuchi-Fujimoto disease be an early presentation of systemic sclerosis?

Clinical rheumatology
2024

The significance of T-BET-positive CD8 T-cells with diminished CD5 expression in Kikuchi-Fujimoto disease.

Journal of clinical and experimental hematopathology : JCEH
2024

Pathogenic role and diagnostic utility of interferon-α in histiocytic necrotizing lymphadenitis.

Clinical immunology (Orlando, Fla.)
2024

Kikuchi Disease "A Lupus Mimicker": A Case Report.

Oman medical journal
2024

Kikuchi-Fujimoto Disease Preceding Overlap Syndrome of Sjögren's Syndrome and Systemic Lupus Erythematosus: Literature Review Based on a Case Report.

Acta medica Indonesiana
2024

Kikuchi-Fujimoto disease following SARS-CoV-2 infection: A rare disease with increased incidence during the COVID-19 pandemic?

Respirology case reports
2024

Clinical features and recurrence predictors of histiocytic necrotizing lymphadenitis in Chinese children.

Pediatric rheumatology online journal
2024

Kikuchi disease complicated with aseptic meningitis following COVID-19 Vaccination: a case report.

Journal of medical case reports
2024

COVID-19 vaccine-associated lymphadenopathy: a review.

Le infezioni in medicina
2024

Hypothermia, bradycardia, and hypotension during glucocorticoid or cyclosporine A therapy in a boy with Kikuchi-Fujimoto disease.

Modern rheumatology case reports
2024

Optic Neuritis in a Pediatric Patient with Kikuchi-Fujimoto Disease: A Case Report and Review of the Literature.

Journal of inflammation research
2024

Kikuchi-Fujimoto disease, simultaneously diagnosed with systemic lupus erythematosus in an Arabic female: an agonizing combination.

The Journal of international medical research
2024

Kikuchi-Fujimoto disease evolves into lupus encephalopathy characterized by venous sinus thrombosis: a case report.

Frontiers in immunology
2024

Distinguishing Kikuchi-Fujimoto disease from lymphoma in patients by clinical and PET/CT features.

Medicine
2024

A Rare Neurological Presentation of Kikuchi-Fujimoto Disease.

JAMA neurology
2024

Abdominal Kikuchi-Fujimoto disease: an unusual presentation of a rare disorder.

QJM : monthly journal of the Association of Physicians
2024

Kikuchi-Fujimoto Disease: A Case Report of Prolonged Fever and Lymphadenopathy in a Young Girl.

Journal of investigative medicine high impact case reports
2024

Kikuchi-Fujimoto Disease: A Rare Presentation in a Young Male.

Cureus
2024

Kikuchi-Fujimoto disease associated with a flare-up of a leukocytoclastic vasculitis: A rare case report and review of literature.

Medicine
2024

Kikuchi-Fujimoto disease during early pregnancy.

The journal of obstetrics and gynaecology research
2024

Pulmonary Involvement of Kikuchi-Fujimoto Disease in Rheumatoid Arthritis.

Journal of clinical rheumatology : practical reports on rheumatic &amp; musculoskeletal diseases
2024

Kikuchi-Fujimoto disease mimicking T-cell lymphoma after COVID-19 vaccination.

American journal of clinical pathology
2024

Histiocytic necrotizing lymphadenitis with hemophagocytic lymphohistiocytosis in adults: A single-center analysis of 5 cases.

Immunity, inflammation and disease
2024

Atypical Kikuchi-Fujimoto Disease: FDG-PET Contribution To The Diagnosis.

European journal of case reports in internal medicine
2024

[Recurrent lymphadenitis was Kikuchi-Fujimoto disease].

Lakartidningen
2024

Occlusive Retinal Vasculitis in a Pediatric Patient With Kikuchi-Fujimoto Disease and Sickle Cell Trait.

Ophthalmic surgery, lasers &amp; imaging retina
2023

Case report: Kikuchi-Fujimoto disease: unveiling a case of recurrent fever and enlarged cervical lymph nodes in a young female patient with a literature review of the immune mechanism.

Frontiers in immunology
2024

Kikuchi-Fujimoto disease, a rare benign disease with atypical histomorphology: more than meets the eye.

Pathology
2023

Kikuchi-Fujimoto Disease in Human Leukocyte Antigen Partially Matched Siblings: A Case Study of Familial Susceptibility.

Cureus
2023

A Case Report: Kikuchi Disease Associated With a Positive Auto-Immune Panel Triggered by COVID-19 Infection.

Cureus
2024

Kikuchi-Fujimoto disease type lymph node reaction with increased plasmacytoid dendritic cells may appear as a side effect following COVID-19 vaccination: Report of a case and literature review.

Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia
2025

DISAPPEARING CHOROIDAL MASS: OPHTHALMIC MANIFESTATIONS OF A PRESUMED KIKUCHI-FUJIMOTO DISEASE.

Retinal cases &amp; brief reports
2023

The lymph node in IgA vasculitis (Henöch-Schonlein purpura).

Journal of hematopathology
2023

A Case Report of Kikuchi Fujimoto Disease as an Antecedent Illness of Systemic Lupus Erythematosus in a Male.

Cureus
2023

Kikuchi-Fujimoto's Disease: A Rare and Underdiagnosed Condition with Possible Renal Involvement.

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia
2023

Case Report: Acute abdomen and large mesenteric mass as another face of multisystem inflammatory syndrome in an adolescent child: measure twice, act once!

Frontiers in pediatrics
2024

Unilateral gluteal myositis as a unique presentation in mesenteric Kikuchi-Fujimoto disease.

Modern rheumatology case reports
2023

The Association of Mycobacterium tuberculosis with Kikuchi Syndrome: A Case Report and Literature Review.

Cureus
2023

Kikuchi Fujimoto Lymphadenitis: A Rare Association With COVID-19 Vaccination.

Cureus
2023

C/EBP homogenous protein-induced Apoptosis in Endoplasmic Reticulum stress has been implicated in Kikuchi-Fujimoto Disease.

Journal of clinical and experimental hematopathology : JCEH
2023

The co-occurrence of Kikuchi-Fujimoto disease and systemic lupus erythematosus: a case report.

Journal of medical case reports
2023

Kikuchi-Fujimoto Disease: A Case of Febrile Cervical Lymphadenopathy With Hematological Abnormalities.

Cureus
2023

Kikuchi-Fujimoto Disease With Systemic Lupus Erythematosus and Systemic Sclerosis Overlap: A Unique Clinical Presentation.

Cureus
2023

A rare acneiform eruption presentation of Kikuchi-Fujimoto disease presenting with concurrent systemic lupus erythematosus.

JAAD case reports
2023

Kikuchi-Fujimoto Disease in a 25-Year-Old Female: A Case Report.

Cureus
2024

Immune-mediated necrotizing myopathy with concomitant development of Kikuchi-Fujimoto disease.

International journal of rheumatic diseases
2023

A retrospective study of 134 patients with cervical region Kikuchi-Fujimoto disease.

Laryngoscope investigative otolaryngology
2023

Elevated serum IFN-γand IFN-γ/IL-6 ratio in Kikuchi-Fujimoto disease.

Pediatric rheumatology online journal
2023

A rare encounter: Kikuchi-Fujimoto disease presenting atypically after BNT162b2 COVID-19 vaccination: a case report.

Scandinavian journal of rheumatology
2023

Kikuchi-Fujimoto Disease: The Unexpected Diagnosis of a Cervical Adenopathy.

Cureus
2023

Kikuchi-Fujimoto disease associated with the central nervous system in children.

Pediatric discovery
2023

Kikuchi-Fujimoto Disease Following COVID-19 Vaccination: Experience at a Population-Based Referral Center.

American journal of clinical pathology
2023

Kikuchi-Fujimoto disease following COVID-19 in a 32-year-old woman.

Journal of clinical and experimental hematopathology : JCEH
2023

Heliotrope rash and puffy fingers due to Kikuchi-Fujimoto disease.

Joint bone spine
2023

Kikuchi-Fujimoto disease: A comprehensive review.

World journal of clinical cases
2023

Kikuchi-Fujimoto Disease in the Axilla after COVID-19 Vaccination: A Case Report.

Current medical imaging
2023

A Rare Case of Kikuchi-Fujimoto Disease.

Cureus
2023

Clonal T-cell proliferations occasionally occur in Kikuchi-Fujimoto disease.

Human pathology
2024

Philadelphia Chromosome Positive Chronic Myelogenous Leukemia Blastic Crisis in a Patient with Unusual Primary Myelofibrosis Characteristics; A Case Report.

Cardiovascular &amp; hematological agents in medicinal chemistry
2023

Kikuchi-Fujimoto Disease: A Rare Cause of Acute Laryngeal Dyspnea.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
2023

Characterization of Kikuchi-Fujimoto Disease in Children and Risk Factors Associated with Its Course.

The Journal of pediatrics
2023

Activated phosphoinositide 3-kinase delta syndrome 2 associated with Kikuchi-Fujimoto disease: a rare Palestinian case report.

Annals of medicine and surgery (2012)
2023

Kikuchi-Fujimoto disease in a 20-year-old female: a case report.

Annals of medicine and surgery (2012)
2023

Kikuchi-Fujimoto Disease: A Case Report of Fever and Lymphadenopathy in a Young White Man.

Federal practitioner : for the health care professionals of the VA, DoD, and PHS
2023

A homozygous loss-of-function C1S mutation is associated with Kikuchi-Fujimoto disease.

Clinical immunology (Orlando, Fla.)
2023

Kikuchi-Fujimoto Disease: a rare type of lymphadenopathy and its plausible relationship with human papillomavirus vaccines.

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia
2023

Kikuchi-Fujimoto disease following SARS-CoV-2 vaccination in a patient with previous history of rhabdomyosarcoma.

Pediatric blood &amp; cancer
2023

CD169 expression on monocytes as a marker for assessing type I interferon status in pediatric inflammatory diseases.

Clinical immunology (Orlando, Fla.)
2024

Kikuchi-Fujimoto disease preceding diagnosis of relapsing-remitting multiple sclerosis.

Acta neurologica Belgica
2023

Kikuchi-Fujimoto disease and membranous nephropathy.

International urology and nephrology
2023

Kikuchi-Fujimoto Disease: A Case of SARS-CoV-2 Infection Triggering the Rare Disease.

Cureus
2023

Systemic Lupus Erythematosus Lymphadenopathy Presenting as Kikuchi-Fujimoto Disease in an Adolescent.

Cureus
2023

Development of Sjögren's syndrome following Kikuchi-Fujimoto disease - A sibling case.

Pediatrics international : official journal of the Japan Pediatric Society
2023

Kikuchi's Disease Diagnosed by an Excisional Biopsy in a Patient With COVID-19.

Cureus
2023

Kikuchi-Fujimoto disease complicated with hemophagocytic lymphohistiocytosis.

Pediatric blood &amp; cancer
2023

Macrophage activation syndrome in children with Kikuchi-Fujimoto disease.

Pediatric rheumatology online journal
2023

Pathological Features and Clinical Characteristics of Kikuchi-Fujimoto Disease: A Tertiary Hospital Experience in Riyadh, Saudi Arabia.

Cureus
2023

Kikuchi-Fujimoto Disease Secondary to Disseminated Brucellosis in an Adolescent Boy.

The Pediatric infectious disease journal
2022

Relapsing Kikuchi-Fujimoto Disease With Hemophagocytic Lymphohistiocytosis.

Cureus
2023

Kikuchi Fujimoto Disease and Post-SARS-COVID-19 Association.

Indian journal of pediatrics
2023

Polyarthritis Associated with Kikuchi-Fujimoto Disease in a Child.

Indian journal of pediatrics
2022

All necrotizing nodes are not tuberculosis - A report of two cases.

The Indian journal of tuberculosis
2023

Kikuchi-Fujimoto Disease and COVID-19 vaccination: pharmacovigilance approach.

European annals of allergy and clinical immunology
2022

Case Report: Multiple autoimmune syndrome (MAS)-An unusual combination.

Frontiers in pediatrics
2022

Kikuchi-Fujimoto Disease: A Rare Cause of Pyrexia of Unknown Origin and Cervical Lymphadenopathy.

Cureus
2022

Sjögren's syndrome presenting as thrombotic thrombocytopenic purpura in a male patient with previous Kikuchi-Fujimoto disease.

Clinical and experimental rheumatology
2022

Kikuchi-Fujimoto disease as the initial manifestation of systemic lupus erythematosus complicated with macrophage activation syndrome: two case reports and a review of literature.

BMC pediatrics
2022

Kikuchi-Fujimoto disease following SARS-CoV-2 vaccination.

BMJ case reports
2022

Kikuchi disease: An alternative diagnosis in patients with axillary lymphadenopathy.

Radiologia
2023

Kikuchi lymphadenitis: A differential diagnosis of tuberculous cervical lymphadenitis.

Tropical doctor
2022

Pathological Findings in COVID-19 and Non-COVID-19 Vaccine-Associated Lymphadenopathy: A Systematic Review.

Journal of clinical medicine
2023

Ankylosing spondylitis with Kikuchi-Fujimoto disease: A case report with literature review.

International journal of rheumatic diseases
2023

Clinicopathologic Analysis of Kikuchi-Fujimoto Disease and Etiologic Exploration Using Metagenomic Next-Generation Sequencing.

Archives of pathology &amp; laboratory medicine
2022

Kikuchi-Fujimoto disease manifesting bilateral lymphadenopathy.

Clinical case reports
2022

Aseptic meningitis in Kikuchi-Fujimoto Disease - Rare manifestation of a rare disease.

eNeurologicalSci
2022

Baffling Case of a Patient With History of Lupus in a COVID-19 Pandemic.

Journal of community hospital internal medicine perspectives
2022

Comparison of Clinical Characteristics and Risk Factors for Recurrence of Kikuchi-Fujimoto Disease Between Children and Adult.

Journal of inflammation research
2022

Kikuchi-Fujimoto Disease in a Crohn's Patient.

Case reports in gastroenterology
2022

A pregnant women with history of hashimoto's thyroiditis diagnosed with Kikuchi-Fujimoto disease: the first case report.

Thyroid research
2023

Kikuchi-Fujimoto Disease: A Distinct Pathological Entity but also an "Overlap" Autoimmune Syndrome: A Systematic Review.

Current rheumatology reviews
2022

Lupus and Kikuchi-Fujimoto Disease: A Combination for Catastrophe.

Cureus
2022

Kikuchi-Fujimoto Disease: A Differential for When It is Not Systemic Lupus Erythematosus.

Case reports in rheumatology
2022

Kikuchi Fujimoto disease as the presenting component of VEXAS syndrome: a case report of a probable association.

Clinical rheumatology
2022

Kikuchi-Fujimoto Disease Following COVID-19 Infection in a 7-Year-Old Girl: A Case Report and Literature Review.

Cureus
2022

[Successful management of Kikuchi-Fujimoto disease caused by SARS-CoV-2].

Orvosi hetilap
2022

Kikuchi-Fujimoto disease in a tertiary care teaching hospital in Coastal South India: A 8-year retrospective study.

F1000Research
2022

Anaemic retinopathy in Kikuchi-Fujimoto disease.

Indian journal of ophthalmology
2022

Multisystem Inflammatory Syndrome in Adults Accompanied with Kikuchi-Fujimoto Disease.

Internal medicine (Tokyo, Japan)
2022

Kikuchi-Fujimoto disease in a child who had a high suspicion of COVID-19 infection.

Journal of hematopathology
2022

Kikuchi-Fujimoto disease - a case report of a paediatric patient.

ARP rheumatology
2022

Kikuchi-Fujimoto's Disease or Histiocytic Necrotizing Lymphadenitis Following mRNA COVID-19 Vaccination: A Rare Case.

Cureus
2022

Kikuchi-Fujimoto disease can present as delayed lymphadenopathy after COVID-19 vaccination.

Human vaccines &amp; immunotherapeutics
2022

A Malignant Mimicker: Features of Kikuchi-Fujimoto Disease in the Pediatric Population.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
Ver todos os 650 no EuropePMC

Associações

Organizações que acompanham esta doença — pra ter apoio e orientação

Ainda não temos associações cadastradas para Doença Kikuchi-Fujimoto.

É de uma associação que acompanha esta doença? Fale com a gente →

Comunidades

Grupos ativos de quem convive com esta doença aqui no Raras

Ainda não existe comunidade no Raras para Doença Kikuchi-Fujimoto

Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.

Tire suas dúvidas

Perguntas, dicas e experiências compartilhadas aqui na página

Participe da discussão

Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.

Fazer login

Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Co-occurrence of disseminated Mycobacterium kansasii infection and Kikuchi-Fujimoto disease in an immunocompetent patient.
    BMJ case reports· 2026· PMID 41500708mais citado
  2. Kikuchi-Fujimoto disease following the subacute phase of Kawasaki disease.
    Pediatrics international : official journal of the Japan Pediatric Society· 2026· PMID 41589679mais citado
  3. Kikuchi-Fujimoto disease presenting as the initial symptom of erythema multiforme.
    Pediatrics and neonatology· 2026· PMID 41365756mais citado
  4. An abnormal immune response masquerading as infectious conditions.
    SAGE open medical case reports· 2026· PMID 41783506mais citado
  5. Localised Kikuchi-Fujimoto Disease With Mediastinal Lymphadenopathy: A Case Initially Mimicking Malignant Lymphoma on Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration Cytology.
    Respirology case reports· 2026· PMID 41743898mais citado
  6. Hydroxychloroquine for Cutaneous Kikuchi-Fujimoto Disease: A Case Report.
    J Dermatol· 2026· PMID 41981854recente
  7. Kikuchi-Fujimoto Disease Mimicking Tuberculous Cervical Lymphadenitis: A Diagnostic Pitfall.
    Ann Afr Med· 2026· PMID 41943403recente
  8. [Kikuchi-Fujimoto disease : a differential diagnosis of febrile lymphadenopathy].
    Rev Med Suisse· 2026· PMID 41923504recente
  9. Kikuchi Disease With Marfanoid Features in a Background of Fever of Unknown Origin.
    Cureus· 2026· PMID 41890508recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:50918(Orphanet)
  2. MONDO:0018864(MONDO)
  3. GARD:6834(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Q1060827(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Doença Kikuchi-Fujimoto
Compêndio · Raras BR

Doença Kikuchi-Fujimoto

ORPHA:50918 · MONDO:0018864
Prevalência
Unknown
Casos
1.052 casos conhecidos
CID-10
I88.1 · Linfadenite crônica, exceto a mesentérica
CID-11
Início
Adolescent, Adult, Childhood, Infancy
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0398367
EuropePMC
Wikidata
Papers 10a
DiscussaoAtiva

Nenhuma novidade ainda. O agente esta monitorando.

0membros
0novidades