A paralisia periódica tireotóxica (TPP) é uma doença neurológica rara caracterizada por episódios recorrentes de paralisia e hipocalemia durante um estado tireotóxico.
Introdução
O que você precisa saber de cara
A paralisia periódica tireotóxica (TPP) é uma doença neurológica rara caracterizada por episódios recorrentes de paralisia e hipocalemia durante um estado tireotóxico.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 20 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 42 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
3 genes identificados com associação a esta condição. Padrão de herança: Multigenic/multifactorial, Not applicable.
Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:16412217, PubMed:29053855). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride an
Postsynaptic cell membraneCell membrane
Epilepsy, X-linked 2, with or without impaired intellectual development and dysmorphic features
A neurologic disorder characterized by variable combinations of epileptic seizure, and a varying degree of intellectual disability and developmental delay. Some patients have dysmorphic facial features or mild skeletal anomalies. In general, males are more severely affected than females, although there is evidence for incomplete penetrance in both sexes.
Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcoplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group
Cell membrane, sarcolemma, T-tubule
Periodic paralysis hypokalemic 1
An autosomal dominant disorder manifested by episodic flaccid generalized muscle weakness associated with falls of serum potassium levels.
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium
Cell membraneEndoplasmic reticulum
Thyrotoxic periodic paralysis 2
A sporadic muscular disorder characterized by episodic weakness and hypokalemia during a thyrotoxic state. It is clinically similar to hereditary hypokalemic periodic paralysis, except for the fact that hyperthyroidism is an absolute requirement for disease manifestation. The disease presents with recurrent episodes of acute muscular weakness of the four extremities that vary in severity from paresis to complete paralysis. Attacks are triggered by ingestion of a high carbohydrate load or strenuous physical activity followed by a period of rest. Thyrotoxic periodic paralysis can occur in association with any cause of hyperthyroidism, but is most commonly associated with Graves disease.
Variantes genéticas (ClinVar)
3,409 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 656 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
2 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Paralisia periódica tireotóxica
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
Pesquisa e ensaios clínicos
2 ensaios clínicos encontrados.
Publicações mais relevantes
Approach to the patient with severe hyperthyroidism-related complications.
Hyperthyroidism is a prevalent endocrine disorder that can lead to severe multisystem complications, including atrial fibrillation (AF), thyrotoxic periodic paralysis (TPP), and thyroid storm (TS). This review discusses the pathophysiology, clinical presentation, and management challenges of these complications through illustrative clinical cases. AF is the most common cardiovascular manifestation, with restoration of euthyroidism and rate control being central to treatment. TPP presents with transient muscle weakness due to hypokalemia from intracellular potassium shift, requiring cautious potassium supplementation and hyperthyroidism control. TS is a life-threatening endocrine emergency characterized by multisystem decompensation, necessitating prompt multimodal therapy including antithyroid drugs, beta-blockers, corticosteroids, and supportive care. Thus, early recognition and tailored management remain the cornerstones of successful treatment for these severe complications of hyperthyroidism.
Silent electrolyte imbalance unmasked by paralysis: a case of hypokalemia in a middle-aged woman.
Hypokalemic periodic paralysis is a rare autosomal dominant muscle channelopathy often misdiagnosed due to its atypical presentation. It is characterized by episodic flaccid paralysis with low serum potassium levels and may be triggered by factors such as high carbohydrate intake, infections, or medications. We report the case of a 25-year-old female who presented with acute ascending flaccid paralysis and was initially misdiagnosed with Guillain-Barré syndrome. Despite biochemical and electrocardiographic evidence of hypokalemia (serum K+: 2.7 mEq/L; electrocardiogram showing U waves and flattened T waves), potassium correction was not initiated. The patient rapidly deteriorated, required mechanical ventilation, and ultimately succumbed to her condition. Thyroid function testing was not performed despite clinical red flags, including a history of anxiety and depression, raising suspicion for thyrotoxic periodic paralysis. This case highlights the diagnostic challenges of hypokalemic paralysis, particularly when presenting as a neurological emergency without classic features. The failure to promptly correct hypokalemia and investigate its underlying etiology contributed to a preventable fatal outcome. A systematic "hypokalemia-first" approach is recommended to avoid such diagnostic delays in similar clinical settings. Timely recognition and correction of hypokalemia, alongside targeted evaluation of underlying causes such as thyrotoxicosis, are critical in patients presenting with acute flaccid paralysis. Standardized emergency protocols could significantly improve outcomes and prevent avoidable fatalities.
Thyrotoxic periodic paralysis: diagnostic and management considerations.
Thyrotoxic periodic paralysis is a rare but potentially life-threatening complication of thyrotoxicosis characterised by hypokalaemia-induced flaccid paralysis due to an intracellular potassium shift rather than total body depletion. We report a male in his early 40s of Filipino origin who awoke with acute bilateral lower-limb weakness after he had consumed a large carbohydrate meal and performed strenuous exercise within the preceding 12 hours. Venous blood gas was normal; initial serum potassium was 1.7 mmol/L with phosphate 1.07 mmol/L. The ECG showed sinus tachycardia, first-degree atrioventricular block and prominent U-waves with QTc 388 ms. Urine potassium/creatinine ratio was 1.7 mmol/mmol (expected <2.0 in hypokalaemia), indicating appropriate renal conservation. A point-of-care thyroid panel did not include thyroid-stimulating hormone (TSH); the laboratory TSH was reported later as suppressed (0.001 mIU/L) with elevated FT4/FT3. There was no diuretic, insulin or β-agonist use. The patient received potassium chloride totalling 80 mEq (≤10 mEq/hour peripherally with continuous ECG monitoring) with serum potassium checks every 1-2 hour, and supplementation was stopped once K+ reached 4.0 mmol/L; propranolol 40 mg orally every 8 hours and methimazole 10 mg orally every 8 hours were started. Muscle strength normalised within 24 hours. This case underscores the diagnostic triad of hypokalaemia without an acid-base disorder, appropriate renal K+ conservation and characteristic ECG changes, and highlights pragmatic dosing/monitoring plus the need for definitive control of thyrotoxicosis to prevent recurrence.
Generation of three iPSC lines from patients with CACNA1S related congenital myopathy.
CACNA1S gene variants are associated with congenital myopathies (CMyo) with triad dysfunction (triadopathies), malignant hyperthermia susceptibility, hypokalemic periodic paralysis and thyrotoxic periodic paralysis. Here, we generated three iPSC lines derived from patients with CMyo linked to both autosomal dominant and recessive CACNA1S variants (CACNA1S-CMyo). The three lines displayed typical iPSC morphology, uniform expression of markers of the undifferentiated state, trilineage differentiation potential and normal karyotypes. As CACNA1S-CMyo are ultra-rare disorders, these lines enable a better in vitro characterization of CACNA1S pathophysiology and can be used to test different treatment approaches.
The association between renin and thyroid-related biomarkers with clinical characteristics and outcomes in hyperthyroid patients.
ObjectiveThere is crosstalk between the thyroid hormone and the renin-angiotensin-aldosterone system, but the clinical application is lacking. Our study aimed to verify the correlation between renin and other thyroid-related biomarkers and their association with treatment prognosis.MethodsThis retrospective study recruited eighty consecutive patients treated for hyperthyroidism in a medical center between 2021 and 2023. Among participants, 53 were newly diagnosed, and 27 were recurrent cases. Laboratory measurements, including renin, aldosterone, and other thyroid-related biomarkers, were assessed, while the associations of biomarkers and clinical symptoms were also analyzed. The clinical variables and biomarkers were entered into the Cox regression model to identify the independent risks associated with time to achieve euthyroidism.ResultsThe correlation matrix showed that free T4 was positively correlated either with T3 (r = 0.755, P < 0.001) or renin (r = 0.341, P = 0.002) but not with aldosterone (r = 0.055, P = 0.631). In ROC analysis for biomarkers and clinical symptoms, either free T4 (AUC = 0.754, P < 0.001) or thyroid-stimulating hormone receptor antibody (TSHRAb) (AUC = 0.645, P = 0.026) demonstrated effective prediction of tachycardia; however, renin was slightly positive for tachycardia without significance (AUC = 0.580, P = 0.233). Regarding thyrotoxic periodic paralysis, the renin showed significant prediction power (AUC = 0.727. P = 0.021) rather than free T4 (AUC = 0.543, P = 0.748) or TSHRAb (AUC = 0.688, P = 0.063). The median time to achieve euthyroidism was 166 days for newly onset patients and 216 days for recurrence, but the time-to-event curves showed no difference (log rank P = 0.728). Under Cox regression modeling, TSHRAb was found to independently predict late euthyroidism (Hazard ratio 0.946, 95% confidence interval 0.901-0.993, P = 0.026), and the renin had no impact (HR 0.995, 95% CI 0.987-1.003, P = 0.215).ConclusionsRenin but not aldosterone was positively correlated with free T4. Certain biomarkers measured at diagnosis were associated with hyperthyroid symptoms. Free T4 and TSHRAb might predict tachycardia, while renin might predict thyrotoxic periodic paralysis; nevertheless, only higher TSHRAb was associated with delayed euthyroid state achievement.
Publicações recentes
Paralysis to Analysis: Unmasking Thyrotoxic Periodic Paralysis in a Middle-Aged Male Patient With Undiagnosed Graves Disease.
Unmasking Hypokalemic Periodic Paralysis: The Rare Role of Levothyroxine in a Pakistani Woman.
Thyrotoxic Paralysis in a Hispanic Woman: An Unusual Presentation of a Neurological Emergency.
Approach to the patient with severe hyperthyroidism-related complications.
Silent electrolyte imbalance unmasked by paralysis: a case of hypokalemia in a middle-aged woman.
📚 EuropePMC430 artigos no totalmostrando 197
Approach to the patient with severe hyperthyroidism-related complications.
The Journal of clinical endocrinology and metabolismSilent electrolyte imbalance unmasked by paralysis: a case of hypokalemia in a middle-aged woman.
Clinical biochemistryThyrotoxic Periodic Paralysis (TPP): A Comprehensive Review with Regional Insights from the Middle East.
CureusA Trajectory of Thyroid Function: From Thyrotoxic Paralysis to Post-ablative Hypothyroidism.
CureusThyrotoxic periodic paralysis: diagnostic and management considerations.
BMJ case reportsThyrotoxic Periodic Paralysis in an Asian Male With Graves' Disease.
CureusExploring Etiologies of Hypokalemic Paralysis: A Case Series.
The Journal of the Association of Physicians of IndiaGuillain-Barré Syndrome and Viral Thyroiditis-Coexisting Together or Viral Thyroiditis as a Cause of Guillain-Barré Syndrome: An Unsolved Enigma!
The Journal of the Association of Physicians of IndiaHyperthyroid Hypokalemic Periodic Paralysis in a Nepali Male; A Case Report.
Clinical case reportsGlucocorticoid-induced Thyrotoxic Periodic Paralysis Following Lumbar Nerve Root Block.
Internal medicine (Tokyo, Japan)Respiratory Failure in Hyperthyroidism: Focus on Thyrotoxic Periodic Paralysis.
CureusTwenty-year trend of thyrotoxicosis and thyrotoxic periodic paralysis: a population-based cohort study.
European thyroid journalHypokalemic Paralysis Is Not Always Periodic: A Case Series.
Case reports in medicineGeneration of three iPSC lines from patients with CACNA1S related congenital myopathy.
Stem cell researchHyperthyroidism in Disguise: A Case of New-Onset Atrial Fibrillation and Acute Reversible Paralysis.
JCEM case reportsRefractory Ventricular Arrhythmias in Thyrotoxic Periodic Paralysis: An Uncommon Presentation of Cardiogenic Shock.
CureusSilent Paralysis: Recurrent Thyrotoxic Periodic Paralysis in a Young Hispanic Male With Graves' Disease.
AACE endocrinology and diabetesRebound Hyperkalemia After Potassium Repletion in Thyrotoxic Periodic Paralysis: A Case Report and Review of Management Implications.
CureusTransient worsening of thyrotoxic myopathy following methimazole and metoprolol initiation in a 12-year-old girl: a case report and literature review.
Journal of pediatric endocrinology & metabolism : JPEMRebound Hyperkalemia in Hypokalemic Thyrotoxic Periodic Paralysis.
The NeurohospitalistUnveiling Thyrotoxic Periodic Paralysis: A Rare Hyperthyroid Complication.
CureusThe association between renin and thyroid-related biomarkers with clinical characteristics and outcomes in hyperthyroid patients.
Science progressInsulin-induced severe thyrotoxic periodic paralysis: A case report.
World journal of clinical casesA Rare Case of Thyrotoxic Periodic Paralysis in a Patient With Concomitant Methimazole-Induced Agranulocytosis.
AACE clinical case reportsThyrotoxic periodic Paralysis With hypoxemia: A case report and a comprehensive review.
Radiology case reports"A Paralyzing Snack": An Endocrine Cause of Paralysis.
Acta medica (Hradec Kralove)Acute Muscle Weakness in Graves' Disease: A Case Report of Hypokalemic Thyrotoxic Periodic Paralysis.
CureusThyrotoxic Periodic Paralysis With Graves' Disease: A Case Report.
CureusThyrotoxic Periodic Paralysis: A Unique Case Highlighting the Diagnostic Challenges and Management.
CureusThyrotoxic Periodic Paralysis: A Rare Cause of Quadriparesis in a Young and Seemingly Healthy Patient.
Medicina (Kaunas, Lithuania)Periodic Paralysis: A Case Series with a Literature Review.
Case reports in neurologyThyrotoxic periodic paralysis - a retrospective study from Southern India.
European thyroid journalFamilial hypokalemic periodic paralysis: a case induced by concurrent hyperthyroidism.
BMC nephrologyThyrotoxic periodic paralysis complicated by carbimazole-associated myositis.
BMJ case reportsUnraveling the Clinical Complexity of Thyrotoxic Periodic Paralysis: A Case Report.
CureusThyrotoxic Periodic Paralysis in a Samoan Male With Metabolic Acidosis: A Case Report and Review of the Literature.
CureusCoincident Thyrotoxic Hypokalemic Periodic Paralysis and Cardiomyopathy.
Journal of investigative medicine high impact case reportsThyrotoxic Periodic Paralysis: A Case Report with Patient Perspective.
Acute medicineA single-center retrospective study on the clinical features of thyrotoxic periodic paralysis.
PloS oneCase report: thyrotoxic periodic paralysis, an unusual cause of hypokalemia.
Acta clinica BelgicaThyrotoxic periodic paralysis: a case report and review of relevant pathophysiology.
Emergencias : revista de la Sociedad Espanola de Medicina de EmergenciasHyperandrogenism and Hypokalemic Thyrotoxic Periodic Paralysis in a North American Adolescent Girl.
JCEM case reportsAtypical Normokalemic Case of Thyrotoxic Periodic Paralysis in a Pediatric Patient.
CureusThyrotoxic Periodic Paralysis, an Unusual Presentation of Paralysis After Spinal Surgery: A Case Report.
CureusRecurrent Thyrotoxic Periodic Paralysis As the Sole Clinical Manifestation of Untreated Hyperthyroidism.
CureusA Rare Case of Hypokalemic Periodic Paralysis With Acute Urinary Retention: Diagnosis and Management.
CureusA rare case of thyrotoxic periodic paralysis revealing Graves' disease in a young Malian.
Clinical case reportsArtificial Intelligence Electrocardiography Detecting Thyrotoxic Periodic Paralysis Following a SARS-CoV-2 Infection.
The American journal of medicineThyrotoxic periodic paralysis presenting with quadriparesis and hyperreflexia.
BMJ case reportsGraves' Disease With Initial Presentation of Thyrotoxic Periodic Paralysis.
CureusA Thyrotoxic Periodic Paralysis Case Study: From Weakness to Wellness.
CureusThyrotoxic Periodic Paralysis as an Ongoing Diagnostic Challenge: A Case Report and Literature Review.
CureusHypokalemic Hypophosphatemic Thyrotoxic Periodic Paralysis Associated with Bipolar Disorder Therapy.
CureusThyrotoxic Periodic Paralysis With Hypokalemia: A Case Study.
CureusCode Pseudo Stroke - A Case of Hypokalaemic Periodic Paralysis Mimicking Stroke.
European journal of case reports in internal medicineThyrotoxic periodic paralysis as the first presentation of Graves' disease: A case report.
Clinical case reportsAn Interesting Case of Weakness and Atrial Tachycardia in the Emergency Department: Thinking Beyond Hearts and Minds.
CureusGitelman syndrome with Graves' disease leading to rhabdomyolysis: a case report and literature review.
BMC nephrologyThyrotoxic periodic paralysis in a Caucasian man without identifiable genetic predisposition: a case report.
Thyroid researchThyrotoxic periodic paralysis: a rare cause of periodic paralysis - a case report.
Annals of medicine and surgery (2012)Thyrotoxic Periodic Paralysis With Severe Hypokalemia Precipitated by Acute Alcohol Intoxication in a Patient With Graves' Disease.
CureusA Case of Thyrotoxic Periodic Paralysis: "I Can't Move!".
CureusHyperthyroidism: aetiology, pathogenesis, diagnosis, management, complications, and prognosis.
The lancet. Diabetes & endocrinologyThyrotoxic periodic paralysis associated with lactic metabolic acidosis: Case report of an African man and review of literature.
Annales d'endocrinologieHigh-dose intravenous hydrocortisone for the treatment of hyperthyroidism: a rare precipitant of thyrotoxicosis periodic paralysis.
Endocrinology, diabetes & metabolism case reportsCase report: SCN4A p.R1135H gene variant in combination with thyrotoxicosis causing hypokalemic periodic paralysis.
Frontiers in neurologyThyrotoxic Periodic Paralysis: An Under-Recognized Cause of Paralysis in Young Hispanic Men.
The Journal of emergency medicineThyrotoxic Periodic Paralysis: The Peril of Potassium Replacement.
CureusUnique Presentation of Thyrotoxic Periodic Paralysis With Urticarial Dermographia.
Military medicineThyrotoxic Periodic Paralysis: Case Presentation With Tetraparesis and Cardiac Dysrhythmia.
CureusThyrotoxic periodic paralysis-still a diagnostic challenge.
Proceedings (Baylor University. Medical Center)Thyrotoxic Periodic Paralysis: An Unusual Cause of Quadriparesis.
CureusIntravenous Iodinated Contrast Induced Thyrotoxic Periodic Paralysis: A Case Report.
Case reports in endocrinologyThyrotoxic periodic paralysis in a patient with Graves' disease: A case report.
Annals of medicine and surgery (2012)[Clinical-epidemiological profile of patients with thyrotoxic periodic paralysis in two peruvian hospitals].
Revista medica del Instituto Mexicano del Seguro SocialCase report: Hyperthyroid hypokalemic periodic paralysis.
Annals of medicine and surgery (2012)Subacute thyroiditis associated with thyrotoxic periodic paralysis after COVID-19 vaccination: a case report.
Endocrinology, diabetes & metabolism case reportsAcute Flaccid Tetraparesis after COVID-19 Infection: Think of the Thyroid.
Case reports in medicine[Muscle weakness in the extremities in a man with Graves' disease].
Ugeskrift for laegerWhen cardiology meets endocrinology: sustained atrial flutter associated with thyrotoxic periodic paralysis.
Oxford medical case reportsElectrocardiographic Manifestation in Thyrotoxic Periodic Paralysis.
CureusThyrotoxic periodic paralysis (TPP): assessment in the emergency department.
BMJ case reportsAcute myocarditis presenting as accelerated junctional rhythm in Graves' disease: A case report.
World journal of clinical cases"I'm so weak I feel paralyzed. Can you help me?" A case on thyrotoxic periodic paralysis.
Journal of the American College of Emergency Physicians openThyrotoxic periodic paralysis presenting as a broad complex tachycardia.
British journal of hospital medicine (London, England : 2005)Thyrotoxic periodic paralysis in two sexagenarian men: A case report.
MedicineAn Unusual Presentation of Thyrotoxicosis: Leg Weakness and Hypokalemia in a 21-Year-Old Male.
Case reports in endocrinologyMaking weight: acute muscle weakness and hypokalaemia exacerbated by thyrotoxicosis factitia in a bodybuilder.
Endocrinology, diabetes & metabolism case reportsRecurrent thyrotoxic periodic paralysis with normokalemia in a 36-year-old man: A case report.
Clinical case reportsVentricular Fibrillation: A Rare Initial Presentation of Thyrotoxic Periodic Paralysis.
JACC. Case reportsThyrotoxic Periodic Paralysis: A Case Report and Literature Review.
Clinical medicine & researchChronic Alcohol Abuse-Induced Hypokalemia Might Lead to Delayed Diagnosis or Misdiagnosis of Thyrotoxic Periodic Paralysis.
CureusArtificial Intelligence-Assisted Electrocardiography for Early Diagnosis of Thyrotoxic Periodic Paralysis.
Journal of the Endocrine SocietyHypokalemic Periodic Paralysis Precipitated by Thyrotoxicosis and Renal Tubular Acidosis.
Case reports in endocrinologyA Case of Hypokalemic Periodic Paralysis in a Young Athlete.
CureusRecurrent, refractory hypokalemia as a diagnostic clue to thyrotoxic periodic paralysis in a patient with acute kidney injury and suspected Guillain-Barre syndrome.
Clinical case reportsThyrotoxic Periodic Paralysis in a Young Hispanic Male With Newly Diagnosed Grave's Disease.
CureusVentricular tachycardia secondary to thyrotoxic periodic paralysis: A case report.
Journal of electrocardiologyPeripheral nerve dysfunction in a patient with thyrotoxic periodic paralysis: Evidence from an axonal prolonged exercise test.
Clinical neurophysiology : official journal of the International Federation of Clinical NeurophysiologyThyrotoxic Periodic Paralysis.
The New England journal of medicineThyrotoxic Periodic Paralysis with Thyroid Storm as the First Presentation of Graves' disease; a Case Report.
Archives of academic emergency medicineRetracted: Thyrotoxic Periodic Paralysis: Clinical Challenges.
Journal of thyroid researchThyrotoxic Periodic Paralysis Causing Back Pain and Leg Weakness: An Unusual Presentation of Hyperthyroidism.
Case reports in endocrinologyNoninvasive ventilator prevents intubation in thyrotoxic hypokalemic periodic paralysis-associated respiratory failure: A case report and literature review.
Tzu chi medical journalThyrotoxic periodic paralysis in an adolescent male: A case report and literature review.
Clinical case reportsThyrotoxic Periodic Paralysis and Complicated Thyrotoxicosis, Two Presentations of Hyperthyroidism with Notable Differences in their Clinical Manifestations: An Experience from a Tertiary Care Hospital in the United States.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsThyrotoxic periodic paralysis after urethral dilatation.
Avicenna journal of medicineThyrotoxic Periodic Paralysis- A Diagnostically Challenging Rare Clinical Entity.
CureusThyrotoxic Muscle Paralysis as a Rare Cause of Reversible Muscle Weakness: A Case Report.
CureusGenome-wide meta-analysis reveals novel susceptibility loci for thyrotoxic periodic paralysis.
European journal of endocrinologyA Literature Review on Thyrotoxic Periodic Paralysis.
CureusTHYROTOXIC PERIODIC PARALYSIS IN A COMPETITIVE BODYBUILDER WITH THYROTOXICOSIS FACTITIA.
AACE clinical case reportsImpact of first-line treatment choice on long-term outcomes of hyperthyroid Graves' disease patients with thyrotoxic periodic paralysis.
Journal of clinical & translational endocrinologyProlonged Exercise Test in Patients With History of Thyrotoxicosis.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic SocietyThyrotoxic Hypokalemic Periodic Paralysis Triggered by Dexamethasone Administration.
Acta medica (Hradec Kralove)Association study in Mexican patients with thyrotoxic hypokalemic periodic paralysis.
Biomedical reportsThyrotoxic Periodic Paralysis-A Misleading Challenge in the Emergency Department.
Diagnostics (Basel, Switzerland)Thyrotoxic Periodic Paralysis With Features of Andersen-Tawil Syndrome: A Case Report and Literature Review.
CureusThyrotoxic periodic paralysis presenting in an African-American teenage male: case report.
International journal of pediatric endocrinologyThyrotoxic Periodic Paralysis with Hypokalemia in an Adult Male from Nepal: A Case Report.
JNMA; journal of the Nepal Medical AssociationUnusual Clinical Presentation of Periodic Paralysis: Case Report and Literature Review.
CureusAnalysis of the genetic background associated with sporadic periodic paralysis in Japanese patients.
Journal of the neurological sciencesFurther evidence for shared genetic susceptibility in both sporadic and Thyrotoxic periodic paralysis.
Journal of the neurological sciencesThyrotoxic Periodic Paralysis: An Incidental Diagnosis!
CureusThyrotoxic periodic paralysis: A retrospective, observational study from India.
The Indian journal of medical researchPeriodic Paralysis Syndromes: A T3 Thyrotoxicosis Case and Review of Literature.
HCA healthcare journal of medicineHYPOKALEMIC PERIODIC PARALYSIS IN A PATIENT WITH EUTHYROID GRAVES DISEASE AND CELIAC DISEASE.
AACE clinical case reportsLow-dose oral propranolol for treatment of thyrotoxic periodic paralysis with hypokalaemia in the emergency department: A case report.
Journal of clinical pharmacy and therapeuticsA rare case of hypokalemic ventricular tachycardia in a patient with thyrotoxic periodic paralysis.
International journal of critical illness and injury scienceThyrotoxic Periodic Paralysis: A Spine Consultation.
Journal of the American Academy of Orthopaedic Surgeons. Global research & reviewsSudden Night Palsy in a Young Man: Thyrotoxic Periodic Paralysis as a First Manifestation of Hyperthyroidism.
The American journal of medicinePharmGKB summary: very important pharmacogene information for CACNA1S.
Pharmacogenetics and genomicsHypokalemic Periodic Paralysis as the First Manifestation of Thyrotropin-Secreting Pituitary Adenoma.
Case reports in endocrinologyContribution of Asian Haplotype of KCNJ18 to Susceptibility to and Ethnic Differences in Thyrotoxic Periodic Paralysis.
The Journal of clinical endocrinology and metabolismThyrotoxic hypokalemic periodic paralysis due to Graves' disease in 2 adolescents.
Annals of pediatric endocrinology & metabolismDon't Trip Over the Trop: An Unusual Presentation of Thyrotoxic Periodic Paralysis.
The American journal of medicineAssessment of Molecular Subtypes in Thyrotoxic Periodic Paralysis and Graves Disease Among Chinese Han Adults: A Population-Based Genome-Wide Association Study.
JAMA network openThyrotoxic periodic paralysis with ventricular tachycardia.
Journal of electrocardiologyClinical and Etiological Spectrum of Hypokalemic Periodic Paralysis in a Tertiary Care Hospital in Pakistan.
Cureus[Muscle weakness with hypokalemia and hyperthyroidism in an adolescent with Down syndrome].
Archivos argentinos de pediatriaThyroxine-induced periodic paralysis: a rare complication of nutritional supplements.
BMJ case reportsA Rare Case of Thyrotoxic Periodic Paralysis After Epidural Steroid Injection: A Case Report and Literature Review.
The American journal of case reportsPeriodic paralysis with normokalemia in a patient with hyperthyroidism: A case report.
MedicineThyrotoxic periodic paralysis complicated by life-threatening acute hypercapnic respiratory failure in a Chinese male with painless thyroiditis.
The American journal of emergency medicineComplicated Gitelman syndrome and autoimmune thyroid disease: a case report with a new homozygous mutation in the SLC12A3 gene and literature review.
BMC endocrine disordersHypokalemic thyrotoxic periodic paralysis. Report of one case.
Medicina clinicaThyrotoxic periodic paralysis: case report and review of the literature.
Electronic physicianLift Then Shift: Thyrotoxic Periodic Paralysis.
The American journal of medicineThyrotoxic Periodic Paralysis and Cardiomyopathy in a Patient with Graves' Disease.
CureusGraves' Disease Presenting with Periodic Paralysis to the Emergency Department.
Case reports in endocrinologyAn atypical presentation of high potassium renal secretion rate in a patient with thyrotoxic periodic paralysis: a case report.
BMC nephrologyDoes thyrotoxic periodic paralysis have a genetic predisposition? A case report.
Annals of clinical biochemistryChanging Management Guidelines in Thyrotoxic Hypokalemic Periodic Paralysis.
The Journal of emergency medicineBilateral Lower Extremity Paralysis in a Caucasian Male Presenting to the Emergency Department.
Case reports in emergency medicineSteroids and Thyrotoxicosis Precipitate Periodic Paralysis.
CureusThyrotoxic Periodic Paralysis as a Presentation of Thyrotoxicosis: A Case Report and review of the literature.
Mediterranean journal of rheumatologyAnalysis of Clinical and Metabolic Profile of Acute Neuromuscular Weakness Related to Hypokalemia.
Acta neurologica TaiwanicaThyrotoxic Channelopathies.
The Journal of the Association of Physicians of IndiaNovel lincRNA Susceptibility Gene and Its Role in Etiopathogenesis of Thyrotoxic Periodic Paralysis.
Journal of the Endocrine SocietyThyrotoxic periodic paralysis: an unusual presentation of hyperthyroidism.
The Netherlands journal of medicineDe novo Mutation in CACNA1S Gene in a 20-Year-Old Man Diagnosed with Metabolic Myopathy.
Archives of Iranian medicinePersistent severe hypokalemia: Gitelman syndrome and differential diagnosis.
Jornal brasileiro de nefrologiaLong Exercise Test in the Interattack Period of Periodic Paralysis: A Useful and Sensitive Diagnostic Tool.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic SocietyPeriodic Paralysis and Encephalopathy as Initial Manifestations of Graves' Disease: Case Report and Review of the Literature.
The neurologistThyrotoxic periodic paralysis: a case study and review of the literature.
Journal of community hospital internal medicine perspectivesThyrotoxic periodic paralysis as an initial presentation of Graves' disease in a Saudi patient.
BMJ case reportsThyrotoxic periodic paralysis: A case report.
International journal of health sciencesNormokalemic Thyrotoxic Periodic Paralysis with Acute Resolution in the Emergency Department.
Clinical practice and cases in emergency medicineA rare cause of thyrotoxic periodic paralysis: liquorice consumption.
Postgraduate medical journalParalysis that easily reverses: a case of thyrotoxic periodic paralysis.
BMJ case reportsDown-regulation of Kir2.6 channel by c-termini mutation D252N and its association with the susceptibility to Thyrotoxic Periodic Paralysis.
NeuroscienceAn Unusual Case of Acute Muscle Weakness.
Acute medicineHypokalemic Paralysis Complicated by Concurrent Hyperthyroidism and Hyperaldosternoism: A Case Report.
The American journal of case reportsAssociation of KCNJ2 Genetic Variants with Susceptibility to Thyrotoxic Periodic Paralysis in Patients with Graves' Disease.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes AssociationIs thyrotoxic periodic paralysis a disease caused by muscle membrane dysfunction?
Muscle & nerveLower-Extremity Weakness in a Teenager Due to Thyrotoxic Periodic Paralysis.
The Journal of emergency medicineSteroid-induced thyrotoxic periodic paralysis during Graves' ophthalmopathy treatment.
Postgraduate medical journalA novel Kir2.6 mutation associated with hypokalemic periodic paralysis.
Clinical neurophysiology : official journal of the International Federation of Clinical NeurophysiologyThyrotoxic Periodic Paralysis: A Concise Review of the Literature.
Current rheumatology reviewsWhole genome and exome sequencing realignment supports the assignment of KCNJ12, KCNJ17, and KCNJ18 paralogous genes in thyrotoxic periodic paralysis locus: functional characterization of two polymorphic Kir2.6 isoforms.
Molecular genetics and genomics : MGGNovel susceptibility gene for nonfamilial hypokalemic periodic paralysis.
NeurologyHypokalaemic Periodic Paralysis in a Patient with Subclinical Hyperthyroidism: A Rare Case.
Journal of clinical and diagnostic research : JCDRA Case of Nonfatal Ventricular Arrhythmia Due to Thyrotoxic Periodic Paralysis in a Saudi Patient as an Initial Presentation of Graves' Disease.
Clinical medicine insights. Case reportsThyrotoxic Periodic Paralysis: A Puzzling Case of Chest Pain and Weakness.
Advanced emergency nursing journalThyrotoxic Periodic Paralysis and Polymorphisms of the ADRB2, AR, and GABRA3 Genes in Men with Graves Disease.
Endocrinology and metabolism (Seoul, Korea)Periodic Paralysis as a New Phenotype of Resistance to Thyroid Hormone Syndrome in a Chinese Male Adult.
The Journal of clinical endocrinology and metabolismThyrotoxic Periodic Paralysis: An Underdiagnosed and Under-recognized Condition.
CureusParalysis as a Presenting Symptom of Hyperthyroidism in an Active Duty Soldier.
U.S. Army Medical Department journalSize of quadriceps femoris may contribute to thyrotoxic periodic paralysis.
Medical hypothesesHypokalemic Paralysis Complicated by Concurrent Hyperthyroidism and Chronic Alcoholism: A Case Report.
MedicineMuscle paralysis in thyrotoxicosis.
BMJ case reportsA case of thyrotoxic periodic paralysis with respiratory failure in an African American woman.
American journal of critical care : an official publication, American Association of Critical-Care NursesThe clinical and genetic features in a cohort of mainland Chinese patients with thyrotoxic periodic paralysis.
BMC neurologyNormokalemic thyrotoxic periodic paralysis with preserved reflexes- a unique case report.
Journal of clinical and diagnostic research : JCDRThyrotoxic periodic paralysis in long standing graves' disease: an unusual presentation with normokalemia.
North American journal of medical sciencesA rare case of thyrotoxic periodic paralysis precipitated by hydrocortisone.
Journal of natural science, biology, and medicineSudden flaccid paralysis.
BMJ case reportsAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Paralisia periódica tireotóxica.
É de uma associação que acompanha esta doença? Fale com a gente →
Comunidades
Grupos ativos de quem convive com esta doença aqui no Raras
Ainda não existe comunidade no Raras para Paralisia periódica tireotóxica
Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.
Tire suas dúvidas
Perguntas, dicas e experiências compartilhadas aqui na página
Participe da discussão
Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.
Fazer loginDoenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Approach to the patient with severe hyperthyroidism-related complications.
- Silent electrolyte imbalance unmasked by paralysis: a case of hypokalemia in a middle-aged woman.
- Thyrotoxic periodic paralysis: diagnostic and management considerations.
- Generation of three iPSC lines from patients with CACNA1S related congenital myopathy.
- The association between renin and thyroid-related biomarkers with clinical characteristics and outcomes in hyperthyroid patients.
- Paralysis to Analysis: Unmasking Thyrotoxic Periodic Paralysis in a Middle-Aged Male Patient With Undiagnosed Graves Disease.
- Unmasking Hypokalemic Periodic Paralysis: The Rare Role of Levothyroxine in a Pakistani Woman.
- Thyrotoxic Paralysis in a Hispanic Woman: An Unusual Presentation of a Neurological Emergency.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:79102(Orphanet)
- MONDO:0019201(MONDO)
- GARD:10814(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
