[Synthesis of glycine betaine affects salt tolerance of Bacillus paralicheniformis].

Arenarine D Promotes Pancreatic β Cell Proliferation Via DYRK1A Inhibition for T1DM Therapy.

A mitochondrial-neuroinflammation-D-serine connection in epilepsy.

Proximity labelling suggests association of the nonhost receptor PSS1 protein with enzymes of multiple defense pathways in Arabidopsis.

Ursodeoxycholic Acid Alleviates DSS/AOM-Induced Colorectal Cancer in Mice by Inhibiting PI3K/Akt/mTOR Signaling Pathway.

Dietary supplementation of coconut meat modulates growth performance, nutritional composition, and internal regulation in Chinese mitten crab (Eriocheir sinensis).

TEM-based Study of the Phenotype of Astrocytes Differentiated from Induced Pluripotent Stem Cells from a Healthy Donor and a Patient with Parkinson's Disease.

Discovery and research progress of CDK8 inhibitors.

XsMYB58 regulates XsLACS8 to promote the accumulation of seed oil in Yellowhorn.

Gender-specific effects of sodium benzoate on cognitive improvement in individuals with dementia: a meta-analysis of randomized controlled trials.

Network Pharmacology and Computational Approach to Unveiling the Mechanism of Berberine in Depression.

A cell cycle-dependent transition of acetylation to phosphorylation regulates timely centrosome maturation.

The gasotransmitters hydrogen sulfide and nitric oxide independently regulate growth, physiology, and secondary metabolism in fenugreek (Trigonella foenum-graecum L.).

Hsa_circ_0000313/miR-1224-3p/MKNK2 Axis Modulates CD4+ T Cells by Activating p38 MAPK Signaling in Myasthenia Gravis.

Expanding horizons: radiolabeled FAPI in imaging of autoimmune diseases.

Integrated proteomic and single-cell transcriptomic profiling elucidates immunomodulatory effects of L-serine in autism spectrum disorder.

[Effects and mechanisms of resveratrol on vascular smooth muscle cell proliferation and neointimal hyperplasia in a carotid artery injury model].

Bileomic identification and quantification of bile acids in rat kidney by UPLC-MS/MS.

Echinacoside regulates the IRE1/XBP1 signaling pathway through HSP72 to reduce endoplasmic reticulum stress and improve diabetic kidney disease.

Development of kallikrein-related peptidase 7 (KLK7) inhibitors and use in a species-adapted model for ovarian cancer.

A soybean EIN transcription factor confers resistance to Phytophthora sojae and favorable agronomic traits.

Regulator of Calcineurin 1 Aggravates Tubular Epithelial Cell Injury in Diabetic Mice Through Promoting Liver Kinase B1 Ubiquitination.

Neuroprotective effects of DPP-4 inhibitors sitagliptin and vildagliptin in Parkinson's disease via autophagy modulation.

Quantifying venom in African snakes: Insights into protein content, yield and body size associations.

Zanthoxylum armatum Essential Oil Attenuates MPP+-Induced Overexpression of Serine Palmitoyltransferase and Neurotoxicity in SH-SY5Y Cell Culture Model of Parkinson's Disease: Evidence From In Vitro and In Silico Studies.

Catabolism of extracellular glutathione supplies cysteine to support tumours.

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model.

Dexmedetomidine inhibits fear memory consolidation via the astrocyte-specific Srebf1-Phgdh pathway in the prelimbic prefrontal cortex.

S1P-sPRR axis in renal ischemia-reperfusion injury: inflammation via a cut.

N‑Alkyl and N‑Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy to Identify Orally Bioavailable Plasma Kallikrein Inhibitors.

SKA2 promotes gastric cancer progression by regulating glutathione metabolism.

Hepatic GAPDH prevents excessive fasting-induced steatosis via serine-dependent inhibition of diacylglycerol synthesis.

Inosine promotes erythrocyte metabolic reprogramming and restores oxygen release for rejuvenation via 2,3-BPG-PNP axis.

Evaluation of serine protein kinase HPrK as an antibacterial target in gram-positive bacteria and mycoplasmas.

Simultaneous inhibition of mTOR and STING as an approach to reduce alpha-synuclein and lysosphingolipid levels in peripheral blood monocytederived macrophages and the SH-SY5Y cell line: implications for therapy of Parkinson's disease.

A Potent Fibrinolytic Enzyme Alp1 from Cordyceps militaris: From Sequence-Function Characterization to in Vivo Antithrombotic Application.

Mistranslation from an endogenous tRNA variant in human pan-genome cell lines.

Nonlinear Bivariate Associations and Mononuclear Cell-Type-Specific Expression Level Differences in the STING Signalling Pathway.

Identification, characterization, and expression profiling of genes encoding tubby-like proteins in rice exposed to realistic environmental contamination of anilofos and bentazone.

[Protective mechanism of electroacupuncture on gastric mucosa in rats with chronic atrophic gastritis based on PI3K/AKT/mTOR signaling pathway].

Pharmaco-behavioral profiling identifies suppressors of autism gene-associated phenotypes in zebrafish.

Multi-omics analysis identifies CCNB1 as a cell cycle factor driving glioblastoma progression and its inhibition by resveratrol.

An Atherosclerosis Model in Mice Induced by Both Partial Carotid Ligation and Overexpression of PCSK9.

Stage-specific GWAS identifies a pleiotropic ankyrin repeat locus near GmSALT3 for salinity tolerance in soybean.

Targeting the mTOR Pathway with Natural Products: A Potential Therapeutic Approach for Autism Spectrum Disorders.

Theasinensin C Mitigates HFrD-Induced Neuroinflammation by Enriching Akkermansia muciniphila and Orchestrating a Gln/Ser-Centered Multiorgan Metabolic Relay to Drive Creatine Biosynthesis.

CAR T cell therapy for fighting IPF: perspectives on a living drug.

Machine learning-assisted analysis of serum metabolomics for identifying biomarkers in intrinsic and idiosyncratic drug-induced liver injury.

The blaKPC-249 -mediated mechanism drives the transition of ST463 Pseudomonas aeruginosa from Ceftazidime-Avibactam sensitivity to resistance during clinical treatment.

Influence of left main-left circumflex artery angle on long-term outcomes in crossover stenting for ostial left circumflex artery lesions: insights from the Multicenter CROSS-LCX Registry.

Peripheral RIPK2 degradation improves neurological outcomes after experimental ischemic stroke.

Validation of human kallikrein 6 in the cerebrospinal fluid of patients with progressive and non-progressive alzheimer's disease: correlation with other biomarkers.

The hippo-YAP1/TEAD1-SLC7A5 axis: uncovering a novel therapeutic target for oxalate-induced renal tubular ferroptosis.

Proteinase 3 Drives Murine Diabetic Kidney Disease by Mediating Caspase-3-dependent Apoptosis of Podocytes.

Evidence from multicenter clinical studies and humanized mouse models indicates that glomerular mesangial IgA2 deposition contributes to the pathogenesis of IgA nephropathy.

Screening of Bradyrhizobium ottawaense with High N2O-reducing Activity from Soybean Nodules in Japan.

Bioactivation and Metabolism of Amino Acid MDMA Prodrugs in Zebrafish Embryos, Human Liver S9, Whole Blood, and Microdosed Human Urine.

Seed ageing increases the influence of native microorganisms on germination.

Molecular Docking and Dynamics-Based Repurposing of Thalidomide and Lenalidomide for GSK-3β Inhibition in AD.

Glycine alleviates the intestinal epithelial barrier damage induced by imidacloprid via promoting metabolic detoxification.

Elucidating the Anti-thrombotic Mechanism of Equiseti hiemalis Herba through Integrated Pharmacology.

The parasite Parvilucifera infectans kills the harmful alga Alexandrium minutum under different salinities and disrupts PSP toxin production.

Cerebellar hypoplasia caused by CASK deficiency.

Biomimetic smartphone sensor for point-of-care l-dopa monitoring.

Isoliquiritigenin restores bone homeostasis in osteoporotic rats by enhancing BMSCs osteogenesis via ERK1/2-mTOR-HIF-1α-glycolytic axis and suppressing inflammation.

Gut-Brain Metabolic Remodeling Mediates the Neuroprotective Effects of Combined Shrimp and Corn Peptides in Scopolamine-Induced Cognitive Impairment.

The Usefulness of Metformin and Ganwei for Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized, Placebo-Controlled Trial.

Uncovering the Potential Mechanisms of Ergothioneine in Neuroinflammation Through Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro Validation.

Genome-Wide Identification and Analysis of Plant Cysteine Oxidase (PCO) Family Genes and Expression Pattern Under Abiotic Stresses in Medicago sativa.

Dissecting the Phospho-Regulatory Landscape of Protein Kinase N1 (PKN1) and Its Downstream Signaling: Functional Insights into the Activity-Dependent and Disease-Relevant Phosphosites.

Glycogen Synthase Kinase 3 (GSK3) Gene Family in Glycine max Under the Effect of Manganese Stress.

GNMT and Its Regulatory MicroRNAs as Biomarkers and Therapeutic Targets for Metabolic Dysfunction-Associated Fatty Liver Disease and Hepatocellular Carcinoma.

Chondrogenesis of Peripheral Blood-Derived Mesenchymal Stromal Cells.

The Interferon-miR-146a-5p-Stat1/Nrf2 Pathway Mediates LRRK2-R1441G-induced M1 over M2 Microglia Activation.

Phase Ib multicenter study of anti-TIM-3 (S095018/Sym023) in combination with anti-PD-1 (Sym021) in patients with advanced/metastatic recurrent biliary tract cancer.

CircRNA-encoded RIPK1-98 protein drives lung adenocarcinoma progression.

Enhancing tenderness and flavor of microwave-dried shrimp through ultrasonic-assisted papain pretreatment: Effects and mechanisms.

Comparative Analysis of Flesh Quality in Triploid and Allotetraploid Pengze Crucian Carp: Nutritional Composition, Flavor Profile, Texture Properties, and Metabolomics Insights.

Integrated network toxicology and computational profiling of acetyl tributyl citrate-related mechanisms in Alzheimer's disease.

Depleting HIF‑1α attenuates the progression of osteosarcoma, but tumorigenicity is sustained through HIF‑independent pathways.

Exploring the Modulation of Extracellular Metabolites in Different Listeria monocytogenes Strains under Cold-Stress.

A system biology-based identification of potential biomarker interlinking the effect of anti-diabetic drug, Metformin, on reduced occurrence of hepatocellular carcinoma.

African swine fever virus pI73R hijacks host mRNA to suppress interferon beta and reveals a druggable target for antiviral intervention.

Effects of Immunoadsorption on Markers of Iron Metabolism: A Case Series.

Mitochondrial uncoupling inhibits serine catabolism via FTO activation in metastatic breast cancer.

Plasma Elastase Screening in Hematological Disease Reveals Its Potential as a Diagnostic and Prognostic Biomarker in Hematological Malignancies.

Tuberous sclerosis complex.

Eukaryotic elongation factor 2 kinase (eEF2K): Mechanisms and pharmacological significance in metabolic diseases.

Physiological disruption, genotoxicity, and body condition impairment in Caiman latirostris yearlings exposed to environmentally relevant pesticide concentrations.

Influence of management and air quality conditions on development of respiratory and gastroenteric disease, and antibiotics phenotypic resistance in domestic canaries (Serinus canaria domesticus).

Prenatal exposure to metal mixtures and the risk of overweight and obesity in school-aged children: insights from metabolomic profiling.

[Analgesic mechanism of Entadae Semen based on its in vivo material basis and regulation of SRC-mediated microglial polarization in a rat model of chronic compression of dorsal root ganglion].

[Saikosaponin B2 improves depressive behavior of VaD mice by promoting oligodendrocyte maturation via regulating Akt/mTOR pathway].

[Transcriptomics and cell experiments reveal regulatory effect of jatrorrhizine on SAT1-mediated ferroptosis in colorectal cancer cell].

[Effects of Acanthopanax senticosus extract on Parkinson's disease mice via untargeted lipidomics across multiple brain regions].

[Advantageous therapeutic pathways and mechanisms of Jianpi Huogu Formula in treating steroid-induced osteonecrosis of femoral head based on multi-source heterogeneous data integration of disease-syndrome-formula framework].

GALNT3 Inhibits the Progression of Cerebral Ischemia-Reperfusion Injury by Stabilizing TREM2 via O-GalNAc Glycosylation.

D-serine and D-alanine supplementation protects against chronic kidney disease.

CSRP3 promotes skeletal muscle remodeling toward aerobic metabolism and enhances exercise endurance through increasing LDHD activity.

A superoxide-driven pathway in the manganese cycle: Biogenic oxidation of Mn(II) by Pseudomonas sp. QJX-1 under glyphosate exposure.

A Stress Response Kinase Cascade Is Conserved in Arabidopsis and Modulated by a Parasite Effector.

Fibroblast-activation protein inhibitors based positron emission tomography (PET) for assessing lung disease: A systematic review with meta-analysis.

Distinct polyp recurrence timing and STK11 mutation status underlie clinical heterogeneity in pediatric Peutz-Jeghers syndrome.

Mitochondrial metabolism restoration via Tramiprosate suppresses mitochondrial ROS-driven foamy macrophage senescence post spinal cord injury.

Glycine receptors in circulating white blood cells regulated by neuroinflammation.

Granzyme B from mast cells contributes to choroidal neovascularization in a model of wet age-related macular degeneration.

Drip irrigation reduces upward translocation of heavy metals in soybeans by enhancing root retention and inhibiting xylem transport.

TDP-43 pathology triggers neuroinflammation and cognitive impairment by inducing microglial necroptosis.

The CDKL5 kinase undergoes liquid-liquid phase separation driven by a serine-rich C-terminal region.

NAD+ hydrolysis catalyzed by SelO is required for mitochondrial homeostasis.

Glycine regulates in vitro nutrient sensing of porcine oocytes through AMPK-mTORC1.

Analysis of the mechanism of MKK4 participating in heat stress response in Mytilus coruscus.

MdRLKT1-MdRAX2-MdMKS1 Module Positively Regulating Resistance to Cytospora mali in Apple.

ORMDL Proteins Turnover via Proteasome and Autophagy Is Cell-Type Dependent and Tied to Ceramide Homeostasis.

Mechanistic insights into lenacapavir-induced off-pathway HIV-1 capsid assembly.

Crystal structure of Vibrio cholerae polysaccharide lyase RbmB bound to Vibrio polysaccharide (VPS) fragments provides insights into substrate recognition and cleavage.

Specific Metabolites Modulate Core Microbes and Microbial Interactions to Drive Fomesafen Dissipation in the Soybean Rhizosphere.

Cofilin hyperphosphorylation triggers TDP-43 pathology in sporadic amyotrophic lateral sclerosis.

Engineering glyphosate tolerance in sugarcane through overexpression of a mutated version of its native EPSPS gene.

Multifunctional Glycine-Carbon Dots Protect Against Arsenic Hepatotoxicity Through Redox Balance and PI3K/AKT Activation.

Circadian oscillations in chromatin accessibility systematically orchestrate rhythmic gene transcription in soybean.

Parthenolide Attenuates Skeletal Muscle Atrophy Through Regulation of Protein Homeostasis and Inhibition of Inflammation.

DRP1/DMNL-1-mediated mitochondrial fission augments Rickettsia parkeri replication in macrophages.

ANXA1-mediated mTOR/FABP4 Inhibition Drives Antifibrotic Macrophage Reprogramming in Lupus Nephritis.

A guide to selecting high-performing antibodies for Alpha-1-antitrypsin (UniProt ID: P01009) for use in western blot, immunoprecipitation and flow cytometry.

Wenyang Decoction Ameliorates DSS-Induced Ulcerative Colitis by Regulating Macrophage Polarization and the PI3K/AKT/mTOR/HIF-1α Signaling Pathway.

Targeting the proline-glycine-proline-protease feed-forward loop attenuates primary graft dysfunction after lung transplantation.

Co-Administration Dosing of Ceftazidime-Avibactam and Aztreonam in Patients with Varying Renal Function for CRE Infections via Monte Carlo Simulation.

Glyphosate promotes calcium oxalate crystal-induced renal injury by modulating the PI3K/Akt-mediated mechanism.

Pesticide exposure among organic and conventional smallholder farmers in Costa Rica and Uganda: biomarker evidence on exposure determinants.

Circulating Rhythmic Metabolites and Causal Risk of Type 2 Diabetes in Adults in the Canadian Longitudinal Study on Aging.

[Clinical application of PI3K/AKT/mTOR pathway testing in breast cancer].

Effect of solid-state fermentation on protein content, amino acid digestibility and anti-nutritional components of common beans, lentils and chickpeas.

SGK1 inhibition restores excitability of cortical neurons derived from Alzheimer's disease patients.

Dual Stress Postischemia Deprivation Depression via Metabolic Disturbance in Rodents.

Untargeted LC-MS-based metabolic fingerprinting of Escherichia coli-associated urinary tract infections and urosepsis: Insights into the urine, serum, and bacterial interactomes.

Early Development of Ocadusertib, a Selective Receptor-Interacting Serine/Threonine-Protein Kinase 1 Inhibitor.

Miro1 in Parkinson's Disease: A Key Regulator of Mitochondrial Homeostasis and Neurodegeneration.

Interaction between transient receptor potential vanilloid 4 and glutamate NMDA receptor subunit 1 mediates endoplasmic reticulum stress and neuroinflammation in postoperative delirium.

Proline/serine-rich coiled-coil 1 alleviates atherosclerosis via remodeling tryptophan metabolism mediated by Akkermansia muciniphila.

The larvicide temephos decreases the fertilization rate of rat spermatozoa by altering different processes of the acrosome reaction and actin polymerization.

Lysine succinylation-mediated energy metabolism imbalance drives brain injury in acute diquat poisoning.

Molecular evidence of Japanese encephalitis virus in poultry: Need to further elucidate JEV epidemiology.

The expression of tyrosine kinase and threonine promotes the progression of lung adenocarcinoma and is linked to a negative prognosis.

Genome-wide characterization of soybean alcohol dehydrogenase (ADH) genes identifies GmADH13 as a positive regulator of the salt stress response.

All-atom simulations reveal distinct pathways for αIIbβ3 activation by biochemical vs. mechanical cues.

Assessment of ROS1 Gene Rearrangement in Non-Small Cell Lung Cancer: Concordance Between ROS1 SP384 Immunohistochemistry and ROS1 FISH Assay in a Single Center in Türkiye.

The metabolic mechanisms of formaldehyde in the roots, stems and leaves of Dieffenbachia maculata.

Prognostic role of systemic inflammatory indices in predicting the severity of acute calculous cholecystitis.

mTOR signaling pathway in primary Sjögren's syndrome: Pathogenesis and potential therapeutic targets (Review).

Characteristics of chromosomal instability‑related lncRNAs associated with progression and prognosis in breast cancer.

Exploratory multi-omics analysis of gut microbiota and fecal metabolites in relation to serum S-equol levels in older adults with osteoporosis from a tropical community: a pilot study.

Tomato-Soy Juice Reduces Inflammation and Modulates the Urinary Metabolome in Adults With Obesity.

Gut microbiota dysbiosis and metabolic abnormalities promote oxidative stress and fibrosis in idiopathic pulmonary fibrosis.

LRRK2 kinase mediates increased GCase activity in microglia in response to IFNγ-induced proinflammatory stimulation.

Genetic variations interact with polybrominated diphenyl ether exposure to alter lipid homeostasis.

A Nuclear Effector of Magnaporthe oryzae Targets a Mitogen-Activated Protein Kinase to Suppress Basal Plant Defense.

The mechanism of oxidative stress induced by nanoplastics in Caenorhabditis elegans: Integrated analysis of transcriptomics and metabolomics.

Characterization of the TREM-1 signaling landscape in human neutrophils.

Metabolic and behavioral effects of neurofibromin result from differential recruitment of MAPK and mTOR signaling.

Immunogenicity of SARS-CoV-2 vaccine prototype based on virus-like particles of hepatitis B core antigen from genotype G and interleukin 12 expressing Semliki Forest virus as a genetic adjuvant.

Integration of proxy intermediate omics traits into a nonlinear two-step model for accurate phenotypic prediction.

Understanding plant resilience by putting photosynthesis and photorespiration in the metabolic context.

Complex interplay of riboregulatory mechanisms at the gcvT-NGFG_01513-gcvH operon of Neisseria gonorrhoeae.

Defining the human lung pathodegradome of the V8 protease from Staphylococcus aureus.

Platelet mTOR Is a Regulator of Sterile Immunothrombosis.

Role of LRRK2 in physiological activities, diseases, and therapy.

Changes in levels of endocannabinoidome mediators in mice with cancer cachexia: links with steatosis and gut microbial dysbiosis.

Convergent evolutionary shifts in AGT targeting between mitochondria and peroxisomes across mammal transitions to herbivory.

The signaling pathways of atherosclerosis regulated by Taohong Siwu Decoction.

Crossover Versus Ostial Single-stent Implantation for Ostial Left Circumflex Artery Lesions: the Multicenter CROSS-LCX Registry.

Large Airway Bronchial Wash Lipidomics as Novel Biomarkers for Chronic Lung Allograft Dysfunction.

The bile acid-CoA ligase, FATP5, is necessary for synthesis of N-acyl taurines in the liver.

Comprehensive first-trimester targeted metabolomics for early prediction and understanding of GDM pathophysiology.

Untargeted metabolomics reveals immune-metabolic signatures in established cases of rheumatoid arthritis.

Sex-based multiomics analysis uncovers metabolic and molecular mediators linking MASH and atherosclerosis.

Salt-Inducible Kinase as a Predictive Biomarker in Laryngeal Squamous Cell Carcinoma: Insights into Treatment Efficacy and Patient Survival.

SPINK2 silencing suppresses leukemic proliferation and restores myeloid commitment via MECOM downregulation in acute myeloid leukaemia.

Association of mitochondrial genetic background with pS65-Ub in Lewy body disease.

Ultra-performance liquid chromatography-mass spectrometry analysis of post-mortem brain tissue reveals specific amino acid profile dysregulation in Parkinson's disease and Alzheimer's disease patients.

A tri-responsive sensor based on co-encapsulated organic probes and multifunctional bimetallic V/Ce-MOF nanozyme in a hydrogel for the detection of l-Serine in saliva.

Collectin-11 regulates osteoclastogenesis and bone maintenance via a complement-dependent mechanism.

Assessment of physical status and analysis of lipidomic and metabolomic alterations in patients with Post-COVID-19 condition.

Trimethoprim: bactericidal or bacteriostatic activity is dependent on bacterial growth conditions.

Revisiting the Nutritional and Health-Promoting Properties of Soy Protein-Based Food Formulations for Infants and Adults.

Saltiness Enhancement Modulated by Hydrophobic Mucoadhesion of Soy Hull Pectic-Like Polysaccharides within a Salivary Mucin Layer.

Glycyl-l-histidyl-l-lysine as a novel co-former in co-amorphous systems: Enhanced aqueous solubility and physical stability.

Ixazomib triggers autophagic degradation of MUC5AC/integrin-β4 and inhibits non-small cell lung cancer progression.

Climate-driven divergence in biophysical and economic impacts of agrivoltaics.

Constitutive activation of TGF-β receptor type I promotes cortical and cancellous bone formation in adult mice.

Therapeutic Effects of Gualou Guizhi Antispasmodic Granules on Spasticity and PANoptosis in a Rat Model of Spinal Cord Injury.

S-equol producing bacteria: isolation and identification from Albino Wistar rat gut microbiota.

Imidazole Propionate Induces Kidney Damage by Activating the ROS-NLRP3 Signaling Pathway Through mTOR Inhibition of Autophagy in Renal Tubular Epithelial Cells.

Viral mechanisms, tropism, and clinical relevance regarding the ophthalmic manifestations of SARS-CoV-2 infection.

ALDH1L2 orchestrates redox-growth coupling in renal carcinoma: pan-cancer evidence and mechanistic validation of the ROS-Akt/mTOR/S6K axis.

N-acetyl-l-leucine lowers α-synuclein levels and improves synaptic function in Parkinson's disease models.

Lipid Pocket Binders Impose Allosteric Changes of Protein Dynamics Around the Active Site of the Protein Kinase p38α.

Symbiosis Islands of Bradyrhizobium Determine Relationships with Host Legumes Lespedeza cuneata and Glycine max.

Engineering Escherichia coli for high-level poly(3-hydroxybutyrate) production: Recent advances and future perspective.