Raras
Buscar doenças, sintomas, genes...
Febre recorrente
ORPHA:91547CID-10 · A68.0CID-11 · 1C1JDOENÇA RARA

Febre recorrente é uma infecção causada por bactérias do gênero Borrelia, exceto aquelas que causam a doença de Lyme e fazem parte do complexo Borrelia burgdorferi.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

Febre recorrente é uma infecção causada por bactérias do gênero Borrelia, exceto aquelas que causam a doença de Lyme e fazem parte do complexo Borrelia burgdorferi.

Pesquisas ativas
1 ensaio
5 total registrados no ClinicalTrials.gov
Publicações científicas
1.830 artigos
Último publicado: 2026 Apr 9

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: A68.0
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🩸
Sangue
7 sintomas
🫃
Digestivo
5 sintomas
🫘
Rins
3 sintomas
💪
Músculos
1 sintomas
❤️
Coração
1 sintomas
🫁
Pulmão
1 sintomas

+ 17 sintomas em outras categorias

Características mais comuns

90%prev.
Trombocitopenia
Muito frequente (99-80%)
90%prev.
Concentração elevada de proteína C-reativa circulante
Muito frequente (99-80%)
90%prev.
Febre
Muito frequente (99-80%)
90%prev.
Aumento da bilirrubina total
Muito frequente (99-80%)
55%prev.
Aumento da concentração circulante de lactato desidrogenase
Frequente (79-30%)
55%prev.
Anemia
Frequente (79-30%)
35sintomas
Muito frequente (4)
Frequente (7)
Ocasional (14)
Muito raro (7)
Sem dados (3)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 35 características clínicas mais associadas, ordenadas por frequência.

TrombocitopeniaThrombocytopenia
Muito frequente (99-80%)90%
Concentração elevada de proteína C-reativa circulanteElevated circulating C-reactive protein concentration
Muito frequente (99-80%)90%
FebreFever
Muito frequente (99-80%)90%
Aumento da bilirrubina totalIncreased total bilirubin
Muito frequente (99-80%)90%
Aumento da concentração circulante de lactato desidrogenaseIncreased circulating lactate dehydrogenase concentration
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico1.830PubMed
Últimos 10 anos200publicações
Pico202367 papers
Linha do tempo
2026Hoje · 2026🧪 1997Primeiro ensaio clínico📈 2023Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
3Fase 31
·Pré-clínico2
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 3 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Febre recorrente

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

5 ensaios clínicos encontrados, 1 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
681 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 681

#1

Louse-borne relapsing fever in Ethiopia: an urgent call for WHO recognition as a neglected tropical disease.

BMJ global health2026 Mar 09

Louse-borne relapsing fever (LBRF), caused by Borrelia recurrentis and transmitted by the human body louse, remains a persistent health emergency in Ethiopia, resulting in preventable mortality among young adults. Its continued endemicity reflects systemic failures and amplifies the syndromic effects of poverty, displacement and social stigma-locally termed 'Qmalam'-which deters care-seeking. Clinical management is further complicated by the potentially fatal Jarisch-Herxheimer reaction following antibiotic treatment. Despite these severe consequences, LBRF remains off the official WHO list of neglected tropical diseases (NTDs), hindering the mobilisation of essential resources and political will. LBRF unequivocally meets WHO criteria for NTD designation, a critical step necessary to catalyse the research, funding and coordinated action required for its elimination. In this viewpoint, we present an integrated framework for addressing transmission, treatment and prediction and issue an urgent call for formal WHO recognition.

#2

Borrelia Infections Under B Cell-Depleting Therapies: A Systematic Review of Diagnostic Challenges and Outcomes With Special Focus on Neurological Forms.

European journal of neurology2026 Jan

B-cell-depleting therapies such as rituximab and newer anti-CD20 agents may impair humoral immune responses and reduce the reliability of serological testing. This systematic review aims to summarize reported cases of Lyme borreliosis and relapsing fever (RF) Borrelia infections in patients receiving B-cell-depleting therapies, focusing on clinical manifestations, diagnostic challenges, and treatment outcomes. A systematic literature search was conducted using PubMed and the Web of Science Core Collection employing search terms linking B-cell-depleting therapies to Lyme borreliosis and to RF Borrelia infections. The most reported cases in the literature were neurological infections due to Borrelia; there were 11 cases of Lyme neuroborreliosis and 8 cases of neurological infections due to B. miyamotoi reported. Lyme neuroborreliosis cases all exhibited negative serology. Pleocytosis of cerebrospinal fluid (CSF) was, however, always present, and PCR could confirm the diagnosis in 8 cases. Diagnosis in all B. miyamotoi cases relied exclusively on direct detection methods. All patients responded to standard antibiotic regimens, although persistent symptoms were reported in some cases. The other infections were 7 erythema migrans (EM), 4 disseminated Lyme borreliosis, and 3 cases of relapsing fever. Neurological Borrelia infections may be underrecognized in patients on B cell-depleting therapies due to atypical presentations and negative serologies. Early consideration of direct diagnostic methods such as PCR or indirect methods such as CSF CXCL13 levels is critical. Neurologists should maintain a high index of suspicion for Borrelia infections in immunocompromised patients presenting with CSF pleocytosis and neurological symptoms.

#3

Comparative analysis of Borrelia's Defence mechanisms and their impact on genetic manipulation of low-passage isolates of Borrelia afzelii and Borrelia garinii.

Current research in microbial sciences2026

Borrelia, a highly prevalent tick-borne pathogen, has a genome with a linear chromosome and numerous linear and circular plasmids. There are three groups of Borrelia: Lyme borreliosis, relapsing fever, and Echidna-reptile. In Europe, Borrelia afzelii and Borrelia garinii are the main causative agents of Lyme borreliosis. The primary defence mechanism of bacteria against bacteriophages and other invading DNA elements is the restriction-modification system (RMS), which discriminates between native and foreign DNA based on their distinct methylation patterns. This present study compares the RMS of all the Borrelia species available in the REBASE database. Additionally, it investigates the effect of the RMS on the transformation efficiency of low-passage B. afzelii and B. garinii isolates. Upon comparing the RMS of 18 Borrelia species, differences in the number, location and characteristics of genes were observed between groups. Given that Lyme borreliosis species exhibit higher genomic plasticity, we hypothesise that they possess a greater number of RMS genes to ensure functionality of the RMS even if some plasmids are lost. In this study, we demonstrate a large increase in transformation efficiency of low-passage strains by using an in vitro methylated shuttle vector, confirming our hypothesis that the RMS of Borrelia recognises pre-methylated vectors as native DNA. The knowledge gained in this study contributes to the understanding of Borrelia defence mechanisms and provides possible explanations for the relatively low transformation efficiency observed in previous studies. Consequently, in vitro methylation can serve as a valuable tool for facilitating studies involving genetic manipulation of Borrelia.

#4

Soft Tick Relapsing Fever.

The New England journal of medicine2026 Mar 12
#5

Listen to the Patient-She is Telling You the Diagnosis.

Annals of family medicine2026 Mar 23

In this narrative, I illustrate the power of long-term primary care, knowing the patient and the land, and recognizing patterns others might miss. A teenage patient presented recurrent fevers and vague symptoms. What first appeared to be a viral illness ultimately revealed itself as tick-borne relapsing fever-"Cave Fever"-a rare but locally known condition. In a setting where relationships matter as much as laboratory results, diagnosis becomes an act of attentive presence. Sometimes, as Osler reminds us, the patient truly is telling us the diagnosis.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC943 artigos no totalmostrando 197

2026

Listen to the Patient-She is Telling You the Diagnosis.

Annals of family medicine
2026

Molecular Investigation of Borrelia spp. in Small Ruminants and Collected Hard Ticks from Them in Kurdistan Province, Western Iran.

Vector borne and zoonotic diseases (Larchmont, N.Y.)
2026

Soft Tick Relapsing Fever.

The New England journal of medicine
2026

Louse-borne relapsing fever in Ethiopia: an urgent call for WHO recognition as a neglected tropical disease.

BMJ global health
2025

[West African tick-borne relapsing fever, a neglected disease of major public health importance in Senegal].

Medecine tropicale et sante internationale
2025

[Identification of tick-borne borreliosis cases by qPCR from rapid malaria diagnostic tests during the Grand Magal of Touba in Senegal].

Medecine tropicale et sante internationale
2026

The ability of relapsing fever Borrelia species to survive in chicken serum in vitro and its correlation to interaction with serum components reactive to a polyclonal anti-complement regulator factor H antibody.

Current research in parasitology &amp; vector-borne diseases
2026

Fever from the shadows: Borrelia duttonii in a migrant in Italy.

IDCases
2026

Relapsing fever Borrelia puertoricensis in migratory Mexican free-tailed bats, Oklahoma, USA, 2022-2023.

bioRxiv : the preprint server for biology
2026

Geographic variation in risk of blacklegged tick-borne coinfections in the eastern United States.

Ticks and tick-borne diseases
2026

Borrelia Infections Under B Cell-Depleting Therapies: A Systematic Review of Diagnostic Challenges and Outcomes With Special Focus on Neurological Forms.

European journal of neurology
2026

Comparative analysis of Borrelia's Defence mechanisms and their impact on genetic manipulation of low-passage isolates of Borrelia afzelii and Borrelia garinii.

Current research in microbial sciences
2025

Prevalence and Susceptibility Status of Body Louse (Pediculus humanus humanus) (Anoplura: Pediculidae) to Deltamethrin in Urmia City, Iran (2024).

Journal of arthropod-borne diseases
2026

Borrelia circulating in soft ticks infesting colonial breeding seabirds along the Portuguese coast.

Ticks and tick-borne diseases
2026

Determinant factors of mortality among patients diagnosed with relapsing fever in a resource-limited setting in Ethiopia.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2026

Borrelia crocidurae meningoencephalitis in a young Senegalense man returning to Tenerife, Canary Islands.

Diagnostic microbiology and infectious disease
2025

Guidelines for tick-borne diseases (excluding Lyme borreliosis): diagnosis and management.

Infectious diseases now
2025

Experimental transmission of the relapsing fever spirochete Borrelia persica in its tick vector Ornithodoros tholozani by transstadial, transovarial, and hyperparasitism routes with description of dynamics within the tick host.

Parasites &amp; vectors
2025

Borrelial Diseases Across Eurasia.

Biology
2025

Paratyphoid fever and relapsing fever in 1812 Napoleon's devastated army.

Current biology : CB
2025

Unusual presentation of complicated relapsing fever with spontaneous hemoperitoneum mimicking surgical acute abdomen: a case report.

International journal of emergency medicine
2026

Molecular detection of a relapsing fever Borrelia in Dermacentor auratus infesting a human, with a brief review of human otoacariasis cases in Malaysia.

Transactions of the Royal Society of Tropical Medicine and Hygiene
2025

Antigenic variation is caused by long plasmid segment conversion in a hard tick-borne relapsing fever Borrelia miyamotoi.

PLoS pathogens
2025

Immunization with mRNA-LNPs Encoding Ornithodoros Argasid Tick Antigens Induces Humoral Immune Responses and Tick Resistance.

Pathogens (Basel, Switzerland)
2025

Molecular detection and phylogenetic characterization of Borrelia theileri and a putative novel Borrelia genotype in Hyalomma dromedarii ticks infesting camels in southern Egypt.

Comparative immunology, microbiology and infectious diseases
2025

Geographic trends in acarological risk reporting for Ixodes scapularis (Acari: Ixodidae)-borne infections across the eastern United States based on data submissions to the ArboNET Tick Module, 2004 to 2023.

Journal of medical entomology
2025

Tick phenology, tick-host associations, and tick-borne pathogen surveillance in a recreational forest of East Texas, USA.

PloS one
2025

Analytical comparison of 11 CE-IVD marked real-time PCR assays for Borrelia burgdorferi sensu lato detection.

European journal of clinical microbiology &amp; infectious diseases : official publication of the European Society of Clinical Microbiology
2025

Unmasking Borrelia species: A comprehensive review of their presence in Iran.

International journal for parasitology. Parasites and wildlife
2025

Chronic meningococcal disease: Systematic literature review.

Journal of infection and public health
2025

Under the scales: Identification of ticks in rehabilitated African pangolins and confiscated scales.

International journal for parasitology. Parasites and wildlife
2025

Isolation and Identification of Secondary Metabolites in Rheum tataricum L.fil. Growing in Kazakhstan and Surveying of Its Anticancer Potential.

Molecules (Basel, Switzerland)
2025

Multilocus Sequence Typing Unveils Two Novel Genospecies of Borrelia burgdorferi Sensu Lato in Ticks Infesting Cricetid Rodents of Northern Chile.

Transboundary and emerging diseases
2025

Current and future applications of species distribution and ecological niche modelling for the study of ticks and tick-borne pathogens.

Medical and veterinary entomology
2025

Distinguishing Jarisch-Herxheimer Reaction From Septic Shock in Leptospirosis Patients: A Case Study.

The American journal of case reports
2025

Borrelia Lineages Adjacent to Zoonotic Clades in Black Flying Foxes (Pteropus alecto), Australia, 2018-2020.

Emerging infectious diseases
2025

Insights into the Regulatory Roles of miRNAs in the Salivary Glands of the Soft Ticks Ornithodoros moubata and Ornithodoros erraticus.

Pathogens (Basel, Switzerland)
2025

Exploring Borrelia in Australia: Isolation, genomic characterisation, and host and vector associations.

Ticks and tick-borne diseases
2025

The rising threat of tickborne infections: A growing public health concern.

The Nurse practitioner
2026

Borrelia miyamotoi in Ixodes ricinus Ticks Removed from Hosts in Northern Italy.

Vector borne and zoonotic diseases (Larchmont, N.Y.)
2025

Genome report: whole-genome assembly of the relapsing fever tick Ornithodoros turicata Dugès (Acari: Argasidae).

G3 (Bethesda, Md.)
2025

Epidemiology and diagnostic challenges of fever of unknown origin (FUO) among adults: A multicenter retrospective study in Northern Italy.

Journal of infection and public health
2025

Ancient Borrelia genomes document the evolutionary history of louse-borne relapsing fever.

Science (New York, N.Y.)
2025

A pathogen's Bronze Age spread challenges longstanding link between disease and early agriculture.

Science (New York, N.Y.)
2025

Vaccinomics-driven selection and validation of protective salivary antigens from the argasid tick Ornithodoros moubata.

Ticks and tick-borne diseases
2025

Serological Analysis Indicating the Exposure of Two Volunteers to Relapsing Fever Borrelia sp. in Nayarit, Mexico.

The American journal of tropical medicine and hygiene
2025

A Case of Travel-Associated Tick-Borne Relapsing Fever in Wisconsin.

WMJ : official publication of the State Medical Society of Wisconsin
2025

[18F]FDG PET-CT in Weber-Christian Disease.

Clinical nuclear medicine
2025

Borrelia miyamotoi DNA in a patient suspected of Lyme borreliosis.

Annals of agricultural and environmental medicine : AAEM
2025

Borrelia miyamotoi in vivo antigenic variation demonstrated by serotype reisolations from infected mice.

Infection and immunity
2025

Use of a mouse model for the isolation of Borrelia puertoricensis from soft ticks.

PloS one
2025

Whole-genome sequences of six Borrelia recurrentis strains obtained via PacBio sequencing.

Microbiology resource announcements
2025

A Day in the Woods in Pregnancy: Fetal and Neonatal Implications.

NeoReviews
2024

The Maturation of the International Health Crisis Response: The Polish Typhus Epidemic of 1916-1923 Compared to the African Ebola Virus Disease Epidemic of 2013-2016: Part I, the Polish Epidemic.

Epidemiologia (Basel, Switzerland)
2024

Borrelia miyamotoi and Borrelia burgdorferi sensu lato widespread in urban areas of the Czech Republic.

Parasites &amp; vectors
2025

New host record and redescription of Amblyomma cordiferum nymphs and larvae infesting Malaysian house rats (Rattus rattus diardii) in Peninsular Malaysia, with molecular evidence of Rickettsia, Borrelia, and Bartonella.

Acta tropica
2024

Rodent group borreliae do occur in wild rodents from the Caribbean region of Colombia.

Parasites &amp; vectors
2024

Tick-Borne Diseases and Pregnancy: A Narrative Review Evaluating Pregnancy Complications Caused by Tick-Borne Diseases.

Tropical medicine and infectious disease
2024

The occurrence of Borrelia miyamotoi in Dermacentor reticulatus and Ixodes ricinus ticks in the Chornobyl Exclusion Zone, Ukraine.

Scientific reports
2024

Vector-borne diseases in Cyprus: A detailed review of the literature.

Tropical biomedicine
2024

First reported cases of Borrelia and dengue co-infection: A case series.

Tropical biomedicine
2024

A distinct Borrelia clade within the relapsing fever group from cat-infesting Haemaphysalis semermis Neumann 1901 (Acari: Ixodidae).

Veterinary research communications
2024

Integrating Systematic Surveys With Historical Data to Model the Distribution of Ornithodoros turicata americanus, a Vector of Epidemiological Concern in North America.

Ecology and evolution
2024

Discovery of Ornithodoros tholozani, the Main Vector of Iranian Tick-born Relapsing Fever.

Archives of Iranian medicine
2023

Travel- and migration-associated epidermal parasitic skin diseases. A review.

Travel medicine and infectious disease
2024

Exposure, infection and disease with the tick-borne pathogen Borrelia miyamotoi in the Netherlands and Sweden, 2007-2019.

The Journal of infection
2024

Incidence of hospitalizations related to Lyme disease and other tick-borne diseases using Discharge Abstract Database, Canada, 2009-2021.

PloS one
2024

Meta-analysis of the Vmp-like sequences of Lyme disease Borrelia: evidence for the evolution of an elaborate antigenic variation system.

Frontiers in microbiology
2024

Complete genome sequence of Borrelia miyamotoi strain MN18-0001, an Am-East-2 strain type isolate derived from an Ixodes scapularis tick (Minnesota).

Microbiology resource announcements
2024

Associations between Ornithodoros spp. Ticks and Mojave Desert Tortoises (Gopherus agassizii) Obtained from Health Assessment Documents.

Journal of wildlife diseases
2024

Mitochondrial genome analysis across different populations reveals the intraspecific variation and phylogeography of the Caucasian soft tick relapsing fever vector, Ornithodoros (Pavlovskyella) verrucosus (Ixodida: Argasidae).

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
2024

Survey of tick-borne relapsing fever borreliae in southern and southeastern Kazakhstan.

Ticks and tick-borne diseases
2024

Spatial and temporal variation of five different pathogens and symbionts in Ixodes ricinus nymphs in the Netherlands.

Current research in parasitology &amp; vector-borne diseases
2024

Under the radar: Transcriptomic responses of bed bugs to an entomopathogen, environmental bacteria, and a human pathogen.

Journal of invertebrate pathology
2024

Microbiota-driven vaccination in soft ticks: Implications for survival, fitness and reproductive capabilities in Ornithodoros moubata.

Molecular ecology
2024

Molecular detection of some zoonotic tick-borne pathogens in ticks collected from camels (Camelus dromedarius) as hosts and wild rodents as potential reservoirs.

Veterinary research communications
2024

Analysis of the Borreliaceae Pangenome Reveals a Distinct Genomic Architecture Conserved Across Phylogenetic Scales.

The Journal of infectious diseases
2025

Pathogen and Host Associations of Soft Ticks Collected in South Texas.

Vector borne and zoonotic diseases (Larchmont, N.Y.)
2024

The crucial role of immunoblots in distinguishing Lyme disease from tick-borne relapsing fever.

Journal of vector borne diseases
2024

Retrospective Analysis of Potential Lyme Disease Clinical Cases in Argentina.

Microorganisms
2024

Production, purification, and quality assessment of borrelial proteins CspZ from Borrelia burgdorferi and FhbA from Borrelia hermsii.

Applied microbiology and biotechnology
2024

Isolation and molecular characterization of a novel relapsing fever group Borrelia from the white-eared opossum Didelphis albiventris in Brazil.

Current research in parasitology &amp; vector-borne diseases
2024

Development and validation of systems for genetic manipulation of the Old World tick-borne relapsing fever spirochete, Borrelia duttonii.

PLoS neglected tropical diseases
2024

Structure analysis of the telomere resolvase from the Lyme disease spirochete Borrelia garinii reveals functional divergence of its C-terminal domain.

Nucleic acids research
2024

Tick-Borne Relapsing Fever Infection from a Bunker, a Case Report on a "One Health" Approach.

Vector borne and zoonotic diseases (Larchmont, N.Y.)
2024

Case 20-2024: A 73-Year-Old Man with Recurrent Fever and Liver Lesions.

The New England journal of medicine
2024

Prevalence of Lyme Disease and Relapsing Fever Borrelia spp. in Vectors, Animals, and Humans within a One Health Approach in Mediterranean Countries.

Pathogens (Basel, Switzerland)
2024

The Imported Relapsing Fever Case Was Not the First Case in Japan.

The American journal of tropical medicine and hygiene
2024

Neglected etiologies of prolonged febrile illnesses in tropical and subtropical regions: A systematic review.

PLoS neglected tropical diseases
2024

Pathogens associated with ticks (Acari: Ixodidae) and mammals in the Orinoquia region of Colombia: An approach to understanding vector-pathogen-host interactions.

Acta tropica
2024

Exploring the transcriptome of immature stages of Ornithodoros hermsi, the soft-tick vector of tick-borne relapsing fever.

Scientific reports
2024

Late-stage borreliosis and substance abuse.

Heliyon
2024

Multifunctional interaction of CihC/FbpC orthologs of relapsing fever spirochetes with host-derived proteins involved in adhesion, fibrinolysis, and complement evasion.

Frontiers in immunology
2024

Development and validation of a multi-target TaqMan qPCR method for detection of Borrelia burgdorferi sensu lato.

Journal of microbiological methods
2024

Systematic investigation of the Borrelia miyamotoi spirochetes in ticks, wildlife and domestic animal hosts in Yunnan province, Southwest China.

One health (Amsterdam, Netherlands)
2024

Statewide surveillance of Ixodes scapularis (Acari: Ixodidae) for the presence of the human pathogen Borrelia miyamotoi (Spirochaetales: Spirochaetaceae), a relapsing fever spirochete in Pennsylvania, USA, 2019-2020.

Journal of medical entomology
2024

Multiple factors affecting Ixodes ricinus ticks and associated pathogens in European temperate ecosystems (northeastern France).

Scientific reports
2024

Soft tick relapsing fever in a traveler returning from Colorado.

Blood
2024

Pediatric Lyme Disease in Northern Italy: An 18-Year Single-Center Case Series.

Microorganisms
2024

Development of a Technique Using Artificial Membrane for In Vitro Rearing of Body Lice Pediculus humanus humanus.

Insects
2024

It's not all about flagella - sticky invasion by pathogenic spirochetes.

Trends in parasitology
2024

Isolation and Genetic Characterization of the Human Relapsing Fever Spirochete Borrelia persica from a Dog with Improved Cultivation Techniques.

Transboundary and emerging diseases
2024

Serological evidence of louse-borne relapsing fever in northern Kenya.

Travel medicine and infectious disease
2024

The global distribution and the risk prediction of relapsing fever group Borrelia: a data review with modelling analysis.

The Lancet. Microbe
2024

The Use of Rabbits Used to Propagate Human Lice for Research.

Comparative medicine
2024

History of the geographic distribution of the western blacklegged tick, Ixodes pacificus, in the United States.

Ticks and tick-borne diseases
2024

Composition and transstadial retention of the salivary glands in Ornithodoros hermsi (Acari: Argasidae).

Journal of medical entomology
2024

Borrelia miyamotoi BipA-like protein, BipM, is a candidate serodiagnostic antigen distinguishing between Lyme disease and relapsing fever Borrelia infections.

Ticks and tick-borne diseases
2024

MINNO: An Open Source Software for Refining Metabolic Networks and Investigating Complex Network Activity Using Empirical Metabolomics Data.

Analytical chemistry
2024

Experimental transmission of a novel relapsing fever group Borrelia harbored by Ornithodoros octodontus (Ixodida: Argasidae) in Chile.

Experimental &amp; applied acarology
2023

Case report: Kikuchi-Fujimoto disease: unveiling a case of recurrent fever and enlarged cervical lymph nodes in a young female patient with a literature review of the immune mechanism.

Frontiers in immunology
2024

Investigating the etiologies of non-malarial febrile illness in Senegal using metagenomic sequencing.

Nature communications
2024

Borrelia turicatae from Ticks in Peridomestic Setting, Camayeca, Mexico.

Emerging infectious diseases
2024

Borrelia nietonii sp. nov.: Relapsing Fever Spirochetes Transmitted By the Tick Ornithodoros hermsi Designated Previously as Borrelia hermsii Genomic Group II.

Vector borne and zoonotic diseases (Larchmont, N.Y.)
2023

Recombinant protein immunoblots for differential diagnosis of tick-borne relapsing fever and Lyme disease.

Journal of vector borne diseases
2024

Tick-borne infections in children in North America.

Current opinion in pediatrics
2024

Use of Specific Borrelia Phages as a New Strategy for Improved Diagnostic Tests.

Methods in molecular biology (Clifton, N.J.)
2023

[Progress in research of epidemiology of relapsing fever and prevention and control measures].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
2023

Molecular evidence of Borrelia theileri and closely related Borrelia spp. in hard ticks infesting domestic animals.

Frontiers in veterinary science
2023

Borrelia puertoricensis in opossums (Didelphis marsupialis) from Colombia.

Parasites &amp; vectors
2023

Evidence for Bartonella quintana in Lice Collected from the Clothes of Ethiopian Homeless Individuals.

Pathogens (Basel, Switzerland)
2023

Molecular surveillance reveals a potential hotspot of tick-borne disease in Yakeshi City, Inner Mongolia.

BMC microbiology
2023

The Need to Establish and Sustain Public Health Emergency Operation Centers for Managing Infectious Disease Outbreaks: Lesson From Response to Louse-Borne Relapsing Fever Outbreak in Jimma, Ethiopia.

Disaster medicine and public health preparedness
2023

Argas persicus and Carios vespertilionis Ticks Infesting Ducks, Domestic Fowls and Bats in Pakistan: First Report on Molecular Survey and Phylogenetic Position of Borrelia anserina.

Veterinary sciences
2023

Autogenous reproduction by Ornithodoros turicata (Ixodida: Argasidae) females and vertical transmission of the tick-borne pathogen Borrelia turicatae (Spirochaetales: Borreliaceae).

Applied and environmental microbiology
2023

Antibody Cross-Reactivity in Serodiagnosis of Lyme Disease.

Antibodies (Basel, Switzerland)
2023

Ornithodoros sonrai Soft Ticks and Associated Bacteria in Senegal.

Pathogens (Basel, Switzerland)
2023

Etiologies of Zoonotic Tropical Febrile Illnesses That Are Not Part of the Notifiable Diseases in Colombia.

Microorganisms
2023

Borrelia persica infection in wild carnivores in Israel: molecular characterization and new potential reservoirs.

Parasites &amp; vectors
2023

Comparative genomics analysis of three conserved plasmid families in the Western Hemisphere soft tick-borne relapsing fever borreliae provides insight into variation in genome structure and antigenic variation systems.

Microbiology spectrum
2024

Flagellate erythema with relapsing fevers and arthralgia.

International journal of dermatology
2023

Prevalence of five human pathogens in host-seeking Ixodes scapularis and Ixodes pacificus by region, state, and county in the contiguous United States generated through national tick surveillance.

Ticks and tick-borne diseases
2023

A microRNA profile of the saliva in the argasid ticks Ornithodoros erraticus and Ornithodoros moubata and prediction of specific target genes.

Ticks and tick-borne diseases
2023

Characterisation and comparative genomics of three new Varanus-associated Borrelia spp. from Indonesia and Australia.

Parasites &amp; vectors
2023

Improving diagnosis of non-malarial fevers in Senegal: Borrelia and the contribution of tick-borne bacteria.

medRxiv : the preprint server for health sciences
2023

Characteristics of Hard Tick Relapsing Fever Caused by Borrelia miyamotoi, United States, 2013-2019.

Emerging infectious diseases
2023

New records of Ornithodoros turicata (Ixodida: Argasidae) in rural and urban sites in the Mexican states of Aguascalientes and Zacatecas indicate the potential for tick-borne relapsing fever.

Experimental &amp; applied acarology
2023

Case report: First case of Borrelia miyamotoi meningitis in an immunocompromised patient in Norway.

IDCases
2023

Emerging bacterial infectious diseases/pathogens vectored by human lice.

Travel medicine and infectious disease
2023

Metabolic Interactive Nodular Network for Omics (MINNO): Refining and investigating metabolic networks based on empirical metabolomics data.

bioRxiv : the preprint server for biology
2023

Rashes With Intermittent Fever After Camping.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2023

Soft Tick Relapsing Fever - United States, 2012-2021.

MMWR. Morbidity and mortality weekly report
2023

Description of a new Pavlovskyella species (Acari: Argasidae) from Chile.

Journal of medical entomology
2023

Vertical transmission of Borrelia turicatae (Spirochaetales: Borreliaceae ) by autogenously reproducing Ornithodoros turicata (Ixodida: Argasidae) female naturally infected with the spirochetes.

bioRxiv : the preprint server for biology
2023

Conformational dynamics of complement protease C1r inhibitor proteins from Lyme disease- and relapsing fever-causing spirochetes.

The Journal of biological chemistry
2023

Molecular Survey of Rodent-Borne Infectious Agents in the Ferlo Region, Senegal.

Genes
2023

Comparison of salivary gland and midgut microbiome in the soft ticks Ornithodoros erraticus and Ornithodoros moubata.

Frontiers in microbiology
2023

Multiomics Reveals Symbionts, Pathogens, and Tissue-Specific Microbiome of Blacklegged Ticks (Ixodes scapularis) from a Lyme Disease Hot Spot in Southeastern Ontario, Canada.

Microbiology spectrum
2023

Combining citizen science and molecular diagnostic methods to investigate the prevalence of Borrelia burgdorferi s.l. and Borrelia miyamotoi in tick pools across Great Britain.

Frontiers in microbiology
2023

Exposure of dogs and cats to Borrelia miyamotoi infected Ixodes ricinus ticks in urban areas of the city of Poznań, west-central Poland.

Ticks and tick-borne diseases
2023

Human Borrelia miyamotoi Infection in North America.

Pathogens (Basel, Switzerland)
2023

Corrigendum to Rickettsia and relapsing fever Borrelia in Alectorobius kelleyi (Ixodida: Argasidae) from peri domestic bats in the northeastern United States. [Ticks and Tick Borne Diseases 2023 May;14(3):102157].

Ticks and tick-borne diseases
2023

Nomenclature for Human Infections Caused by Relapsing Fever Borrelia.

Emerging infectious diseases
2023

Genome Sequence of a Clinical Isolate of the Human Pathogenic Strain "Candidatus Borrelia fainii" Qtaro.

Microbiology resource announcements
2023

Identifying suitable habitat for Ixodes scapularis (Acari: Ixodidae) infected with Anaplasma phagocytophilum (Rickettsiales: Anaplasmataceae), Babesia microti (Piroplasmida: Babesiidae), and Borrelia miyamotoi (Spirochaetales: Spirochaetaceae) to guide surveillance efforts in the eastern United States.

Journal of medical entomology
2023

A serological assay to detect and differentiate rodent exposure to soft tick and hard tick relapsing fever infections in the United States.

Ticks and tick-borne diseases
2023

Rickettsia and relapsing fever Borrelia in Alectorobius kelleyi (Ixodida: Argasidae) from peri domestic bats in the northeastern United States.

Ticks and tick-borne diseases
2023

Quantitative Polymerase Chain Reaction from Malaria Rapid Diagnostic Tests to Detect Borrelia crocidurae, the Agent of Tick-Borne Relapsing Fever, in Febrile Patients in Senegal.

The American journal of tropical medicine and hygiene
2023

"Conformational dynamics of C1r inhibitor proteins from Lyme disease and relapsing fever spirochetes".

bioRxiv : the preprint server for biology
2023

Borrelia miyamotoi in wild rodents from four different regions of Turkey.

Ticks and tick-borne diseases
2023

The Surveillance of Borrelia Species in Camelus dromedarius and Associated Ticks: The First Detection of Borrelia miyamotoi in Egypt.

Veterinary sciences
2023

Borrelia miyamotoi: A Comprehensive Review.

Pathogens (Basel, Switzerland)
2023

A Novel Relapsing Fever Group Borrelia Isolated from Ornithodoros Ticks of the Brazilian Caatinga.

Microorganisms
2023

Molecular Surveillance for Vector-Borne Bacteria in Rodents and Tree Shrews of Peninsular Malaysia Oil Palm Plantations.

Tropical medicine and infectious disease
2023

Post-infectious vasculitis secondary to Campylobacter coli infection.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2023

Analysis of variable major protein antigenic variation in the relapsing fever spirochete, Borrelia miyamotoi, in response to polyclonal antibody selection pressure.

PloS one
2023

Electrochemical Detection of Sulfadiazine by Sensors based on Chemically Modified Carbon Electrodes: A Review.

Current topics in medicinal chemistry
2023

Borrelia miyamotoi a neglected tick-borne relapsing fever spirochete in Thailand.

PLoS neglected tropical diseases
2023

Relapsing Fever: A Rare Cause of Pediatric Fever of Unknown Origin.

Clinical pediatrics
2023

Morphological and molecular confirmation of Ornithodoros hasei (Schulze, 1935) (Acari: Argasidae) in Colombia.

Ticks and tick-borne diseases
2023

A simple non-invasive method to collect soft tick saliva reveals differences in Ornithodoros moubata saliva composition between ticks infected and uninfected with Borrelia duttonii spirochetes.

Frontiers in cellular and infection microbiology
2023

Evaluation of Immunocompetent Mouse Models for Borrelia miyamotoi Infection.

Microbiology spectrum
2023

Relapsing Fever Caused by Borrelia lonestari after Tick Bite in Alabama, USA.

Emerging infectious diseases
2023

Comparative Analysis of Tick-Borne Relapsing Fever Spirochaetes from Ethiopia and Nigeria.

Pathogens (Basel, Switzerland)
2023

Detection of Old and New World Relapsing Fever Borreliae in Ornithodoros Ticks Collected from Warthog Burrows in Zambia.

Microorganisms
2023

Case Report: Exposure to Relapsing Fever Group Borreliae in Patients with Undifferentiated Febrile Illness in Mexico.

The American journal of tropical medicine and hygiene
2023

Molecular evidence of Borrelia spp. in bats from Córdoba Department, northwest Colombia.

Parasites &amp; vectors
2022

Epistaxis and thrombocytopenia as major presentations of louse borne relapsing fever: Hospital-based study.

PloS one
2022

Tick-borne diseases in Egypt: A one health perspective.

One health (Amsterdam, Netherlands)
2022

Pathogen Detection in Ornithodoros sonrai Ticks and Invasive House Mice Mus musculus domesticus in Senegal.

Microorganisms
2022

Is Borrelia burgdorferi Sensu Stricto in South America? First Molecular Evidence of Its Presence in Colombia.

Tropical medicine and infectious disease
2022

Expression of Concern: Multispacer Sequence Typing Relapsing Fever Borreliae in Africa.

PLoS neglected tropical diseases
2022

Expression of Concern: Head Lice of Pygmies Reveal the Presence of Relapsing Fever Borreliae in the Republic of Congo.

PLoS neglected tropical diseases
2022

Expression of Concern: Detection of relapsing fever Borrelia spp., Bartonella spp. and Anaplasmataceae bacteria in argasid ticks in Algeria.

PLoS neglected tropical diseases
2022

Expression of Concern: Tick-borne relapsing fever Borreliosis, a major public health problem overlooked in Senegal.

PLoS neglected tropical diseases
2022

Cultivation Methods of Spirochetes from Borrelia burgdorferi Sensu Lato Complex and Relapsing Fever Borrelia.

Journal of visualized experiments : JoVE
2023

Bioactive phytocompounds against specific target proteins of Borrelia recurrentis responsible for louse-borne relapsing fever: Genomics and structural bioinformatics evidence.

Medical and veterinary entomology
2023

15-year Borrelia prevalence and species distribution monitoring in Ixodes ricinus/inopinatus populations in the city of Hanover, Germany.

Ticks and tick-borne diseases
2022

Development and Validation of a Protein Array for Detection of Antibodies against the Tick-Borne Pathogen Borrelia miyamotoi.

Microbiology spectrum
2022

[The Less Frequent Tick-borne Infections in Central Europe].

Therapeutische Umschau. Revue therapeutique
2023

First molecular detection of Borrelia theileri subclinical infection in a cow from Brazil.

Veterinary research communications
2023

Novel Borrelia Genotypes from Brazil Indicate a New Group of Borrelia spp. Associated with South American Bats.

Journal of medical entomology
2022

Characterization of the arthropod associated lipoprotein (Alp) in the tick-mammalian transmission cycle of Borrelia turicatae.

Ticks and tick-borne diseases
2022

Attenuation of relapsing fever neuroborreliosis in mice by IL-17A blockade.

Proceedings of the National Academy of Sciences of the United States of America
2022

Molecular detection and identification of relapsing fever Borrelia in ticks and wild small mammals in China.

Emerging microbes &amp; infections
2022

Identification of amino acid domains of Borrelia burgdorferi P66 that are surface exposed and important for localization, oligomerization, and porin function of the protein.

Frontiers in cellular and infection microbiology
2022

Novel approaches for the serodiagnosis of louse-borne relapsing fever.

Frontiers in cellular and infection microbiology
Ver todos os 943 no EuropePMC

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Louse-borne relapsing fever in Ethiopia: an urgent call for WHO recognition as a neglected tropical disease.
    BMJ global health· 2026· PMID 41802823mais citado
  2. Borrelia Infections Under B Cell-Depleting Therapies: A Systematic Review of Diagnostic Challenges and Outcomes With Special Focus on Neurological Forms.
    European journal of neurology· 2026· PMID 41560401mais citado
  3. Comparative analysis of Borrelia's Defence mechanisms and their impact on genetic manipulation of low-passage isolates of Borrelia afzelii and Borrelia garinii.
    Current research in microbial sciences· 2026· PMID 41551585mais citado
  4. Soft Tick Relapsing Fever.
    The New England journal of medicine· 2026· PMID 41812195mais citado
  5. Listen to the Patient-She is Telling You the Diagnosis.
    Annals of family medicine· 2026· PMID 41876116mais citado
  6. Neurological manifestations in a cat with tick-borne relapsing fever caused by Borrelia persica.
    Res Vet Sci· 2026· PMID 41985201recente
  7. Blood Smear Examination Matters: an Incidental Case of Tick-Borne Relapsing Fever in a Traveller Returning from Senegal.
    Travel Med Infect Dis· 2026· PMID 41974313recente
  8. Transstadial and transovarial perpetuations of Borrelia venezuelensis in Ornithodoros rudis, with demonstration of vector competence.
    Exp Appl Acarol· 2026· PMID 41949803recente
  9. Molecular Investigation of Borrelia spp. in Small Ruminants and Collected Hard Ticks from Them in Kurdistan Province, Western Iran.
    Vector Borne Zoonotic Dis· 2026· PMID 41874269recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:91547(Orphanet)
  2. MONDO:0019633(MONDO)
  3. GARD:19171(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q690032(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Febre recorrente
Compêndio · Raras BR

Febre recorrente

ORPHA:91547 · MONDO:0019633
Prevalência
Unknown
Herança
Not applicable
CID-10
A68.0 · Febre recorrente transmitida por piolhos
CID-11
Ensaios
1 ativos
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0035021
Repurposing
22 candidatos
aspirincyclooxygenase inhibitor
chloramphenicolbacterial 50S ribosomal subunit inhibitor
chloramphenicol-palmitateprotein synthesis inhibitor
+17 outros
EuropePMC
Wikidata
Wikipedia
Papers 10a
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