Raras
Buscar doenças, sintomas, genes...
Apoplexia da pituitária
ORPHA:95613CID-10 · E23.6CID-11 · 5A61.0DOENÇA RARA

Doença rara, potencialmente fatal, causada por infarto isquêmico agudo ou hemorragia na glândula pituitária. Está mais frequentemente associado à presença de adenoma da glândula pituitária. Os sinais e sintomas incluem dor de cabeça, vômitos, distúrbios visuais e disfunção endócrina.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

Doença rara, potencialmente fatal, causada por infarto isquêmico agudo ou hemorragia na glândula pituitária. Está mais frequentemente associado à presença de adenoma da glândula pituitária. Os sinais e sintomas incluem dor de cabeça, vômitos, distúrbios visuais e disfunção endócrina.

Publicações científicas
1.577 artigos
Último publicado: 2026 Apr

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: E23.6
Você se identifica com essa condição?
O Raras está aqui pra te apoiar — com ou sem diagnóstico

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

📏
Crescimento
8 sintomas
👁️
Olhos
3 sintomas
🫘
Rins
2 sintomas
🩸
Sangue
1 sintomas
🧠
Neurológico
1 sintomas
🫃
Digestivo
1 sintomas

+ 25 sintomas em outras categorias

Características mais comuns

90%prev.
Cefaleia em trovoada
Muito frequente (99-80%)
90%prev.
Hemianopsia bitemporal
Muito frequente (99-80%)
55%prev.
Paralisia de nervo craniano
Frequente (79-30%)
55%prev.
Diplopia
Frequente (79-30%)
55%prev.
Teste de perimetria cinética anormal
Frequente (79-30%)
55%prev.
Concentração reduzida de prolactina circulante
Frequente (79-30%)
41sintomas
Muito frequente (2)
Frequente (17)
Ocasional (14)
Muito raro (8)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 41 características clínicas mais associadas, ordenadas por frequência.

Cefaleia em trovoadaThunderclap headache
Muito frequente (99-80%)90%
Hemianopsia bitemporalBitemporal hemianopia
Muito frequente (99-80%)90%
Paralisia de nervo cranianoCranial nerve paralysis
Frequente (79-30%)55%
Diplopia
Frequente (79-30%)55%
Teste de perimetria cinética anormalAbnormal kinetic perimetry test
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico1.577PubMed
Últimos 10 anos200publicações
Pico202472 papers
Linha do tempo
2026Hoje · 2026🧪 2006Primeiro ensaio clínico📈 2024Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
·Pré-clínico4
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 4 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Apoplexia da pituitária

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

0 ensaios clínicos encontrados.

Distribuição por fase
Ver todos no ClinicalTrials.gov
🧪 Está conduzindo uma pesquisa?
Divulgue para pacientes e familiares que acompanham esta doença.
Divulgar pesquisa →

Publicações mais relevantes

Timeline de publicações
711 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 711

#1

Nivolumab rechallenge after pituitary apoplexy associated with nivolumab plus ipilimumab in a patient with pituitary adenoma and rectal melanoma: a case report and literature review.

Journal of pharmaceutical health care and sciences2026 Mar 19
#2

Severe Headache and Acute Blindness: A Case of Pituitary Apoplexy.

Clinical case reports2026 Mar

Pituitary apoplexy is a rare, life-threatening syndrome that commonly occurs in the adenomatous pituitary gland. It presents with a myriad of severe neuroendocrine and ophthalmological signs and symptoms. Early diagnosis and prompt treatment are vital in the management of pituitary apoplexy. This case report describes a 56-year-old woman who reported to the neurology clinic with 1 week's history of visual loss, and a severe headache, on the background of a 2-year history of pituitary adenoma with poor follow-up. The patient underwent transsphenoidal surgery. She regained vision in the right eye, but no perception of light in the left eye. Patients with headaches and impaired visual field should be screened for pituitary adenoma. Signs and symptoms may be reversible with early diagnosis and prompt treatment of pituitary apoplexy.

#3

Cabergoline-Resistant Recurrent Macroprolactinoma During Pregnancy: A Case Report and Review of the Literature.

Cureus2026 Jan

We report a rare case of cabergoline-resistant recurrent macroprolactinoma during pregnancy. A 34-year-old woman, 17 weeks pregnant, presented with a four-week history of headache and a one-day history of visual disturbance. The medical history was significant for a macroprolactinoma with pituitary apoplexy, which was treated with an emergent pituitary resection approximately two years and four months before this presentation. At that time, postoperative prolactin levels improved but remained elevated despite gradually escalating cabergoline doses up to 6 mg per week. Our patient met the established criteria for cabergoline resistance, with persistently elevated prolactin levels despite high-dose cabergoline therapy. She was dealing with resistant hyperprolactinemia, causing infertility. The patient decided to conceive, and pre-pregnancy counseling was done by reproductive endocrinology, maternal-fetal medicine, and a genetic counselor. Before conception, magnetic resonance imaging (MRI) of the pituitary showed postoperative changes from transsphenoidal hypophysectomy and expanded partial sella, with no clear tumor, and the prolactin level was 228 ng/mL (non-pregnant normal reference range: 3-30 ng/mL). She had in vitro fertilization done, and cabergoline was discontinued on confirmation of pregnancy. On presentation, MRI of the pituitary revealed a recurrent pituitary macroadenoma (29 × 29 × 27 mm). She developed symptomatic tumor recurrence within three months of stopping cabergoline, and her prolactin level was 1,669.8 ng/mL (normal reference range in pregnancy: 10-209 ng/mL). She was treated with steroids, and cabergoline was restarted. However, the tumor continued to grow, causing symptoms necessitating repeat urgent pituitary resection in the second trimester of pregnancy. She remained on cabergoline through the rest of her pregnancy and delivered a healthy male neonate via cesarean section, done for breech presentation at 39 weeks. The postpartum, fetal, and neonatal stages were all uneventful. This case highlights the complexities of managing dopamine agonist-resistant macroprolactinomas during pregnancy and underscores the importance of individualized, multidisciplinary decision-making to optimize maternal and fetal outcomes.

#4

Pituitary Apoplexy Following Gonadotropin-Releasing Hormone Agonist Administration for Prostate Cancer.

IJU case reports2026 Mar

Pituitary apoplexy represents an uncommon endocrine emergency with potentially life-threatening consequences. Gonadotropin-releasing hormone agonist used for prostate cancer has the potential to induce pituitary apoplexy, particularly in the setting of a preexisting pituitary adenoma. A 76-year-old male with prostate cancer initially chose active surveillance; however, prostate-specific antigen (PSA) elevation required hormonal therapy 5 years later. A pancreatic islet tumor had been previously identified; however, its details were unavailable. He was presented to the emergency department 24 h after receiving the first gonadotropin-releasing hormone agonist injection. He showed severe headache, general fatigue, diplopia, and ptosis of the right eye. Brain MRI revealed a right deviated suprasellar pituitary adenoma with hemorrhagic infarction. He was conservatively treated with high-dose steroids; symptoms improved within 1 week. Clinicians should be aware of the association of pituitary apoplexy with the use of gonadotropin-releasing hormone agonist and should ask about the patient's past history of multiple endocrine neoplasia (MEN).

#5

Differences in clinical course between pituitary apoplexy and non-apoplexy patients with nonfunctioning pituitary neuroendocrine tumors.

Neurosurgical review2026 Feb 25

Although the imaging diagnosis of pituitary apoplexy has been well reported, research on the clinical symptoms of this condition remains scarce. This study aimed to provide an accurate clinical evidence of patients with pituitary apoplexy. This retrospective study used data from 311 patients with nonfunctioning pituitary neuroendocrine tumors treated with initial transsphenoidal surgery. Pituitary apoplexy was defined as the presence of acute headache or visual impairment along with a tumor with pathological findings of necrotic changes and/or diffuse hemorrhage. To alleviate the effect of tumor volume and patient sex, propensity score matching was performed between the pituitary apoplexy (APO) and non-apoplexy (non-APO) groups. A total of 20 patients were matched to each of the two groups, and their data were statistically compared. Compared with the non-APO group, the APO group had higher preoperative body temperature (degrees Celsius) and lower levels of preoperative serum sodium (mEq/L) and prolactin (ng/mL). Receiver operating characteristic curve analysis revealed that the optimal prolactin level that supports the diagnosis of pituitary apoplexy was 7.5 ng/mL (AUC = 0.75250, 50% sensitivity, 100% specificity). The patients in the APO group were further divided into two subgroups, those who were evaluated within 3 days of onset and those who were evaluated after 3 days of onset, and the former subgroup was found to have lower serum PRL and sodium level as well as higher body temperature. Hyperthermia, hyponatremia, and hypoprolactinemia indicate the possibility of pituitary apoplexy.Trial number: E-2020-2022, June 1, 2022, retrospectively registered.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC1.087 artigos no totalmostrando 197

2026

Nivolumab rechallenge after pituitary apoplexy associated with nivolumab plus ipilimumab in a patient with pituitary adenoma and rectal melanoma: a case report and literature review.

Journal of pharmaceutical health care and sciences
2026

Pituitary apoplexy: long-term endocrine and neuro-ophthalmologic outcomes according to management strategy and timing.

Endocrine
2026

Pituitary apoplexy: lessons from the Spanish registry for clinical stratification supported by advanced imaging.

Endocrinologia, diabetes y nutricion
2026

Severe Headache and Acute Blindness: A Case of Pituitary Apoplexy.

Clinical case reports
2026

Cabergoline-Resistant Recurrent Macroprolactinoma During Pregnancy: A Case Report and Review of the Literature.

Cureus
2026

Pituitary Apoplexy Following Gonadotropin-Releasing Hormone Agonist Administration for Prostate Cancer.

IJU case reports
2026

Differences in clinical course between pituitary apoplexy and non-apoplexy patients with nonfunctioning pituitary neuroendocrine tumors.

Neurosurgical review
2026

Intravenous Thrombolysis for Ischemic Stroke Patients with Pituitary Neoplasms: A Nationwide Study and Scoping Review.

NeuroSci
2026

Management of endocrine disease: update on the management of pituitary apoplexy.

European journal of endocrinology
2026

Isolated primary amenorrhea in a 22-year-old female revealing pituitary apoplexy: a rare case report.

Annals of medicine and surgery (2012)
2026

Intrasellar meningioma versus pituitary apoplexy in the setting of postpartum hemorrhage: a case report.

BMC pregnancy and childbirth
2026

Neurologic Complications of Endocrine Disorders.

Continuum (Minneapolis, Minn.)
2026

A Case Report of Growth Hormone-Secreting Pituitary Adenoma Complicated by Apoplexy With Atypical Clinical Presentation.

Case reports in medicine
2025

Craniofacial and Radiological Features as Diagnostic Clues to Unmask Acromegaly: A Case Report.

Cureus
2026

Patients With Pituitary Neuroendocrine Tumours Requiring Neurosurgery -Who Is Referring Them?

Clinical endocrinology
2025

Pituitary apoplexy in the setting of adrenocorticotropic hormone-secreting adenoma: A systematic review and illustrative case.

Brain circulation
2025

Correlation between intrasellar pressure, pituitary adenoma invasiveness, pituitary dysfunction, and apoplexy.

Frontiers in endocrinology
2025

Pituitary Macroadenoma: A Conservative Approach to Apoplexy.

Cureus
2025

Pituitary Apoplexy: A Case Series.

Cureus
2025

Unusual spontaneous resolution of a nonfunctioning pituitary macroadenoma: A case report.

Surgical neurology international
2026

Spontaneous regression of a growth hormone-secreting pituitary adenoma following thyroidectomy for toxic multinodular goiter with superior vena cava obstruction: Report of a rare case.

Medicine international
2025

More Than a Headache: Unveiling Pituitary Apoplexy Following Acute Coronary Syndrome.

Cureus
2025

High-Risk Prostate Cancer in a Patient with Untreated Prolactinoma and Castrate-Level Testosterone Suppression: A Case Report.

Case reports in oncology
2025

Breast Cancer Metastasis to the Pituitary Presenting With Apoplexy.

Cureus
2025

Epidemiology, presentation and outcomes in pituitary apoplexy: a population-based study in Malta.

Endocrine oncology (Bristol, England)
2025

Pituitary Apoplexy: An Uncommon Cause of Postpartum Headache.

Cureus
2025

Pituitary Apoplexy Masquerading as Intractable Headache in a 66-Year-Old Man: A Case Report.

The Journal of emergency medicine
2026

Clinical presentation and outcomes of pituitary apoplexy in patients with PitNETs: a real world Italian multicenter study.

Journal of endocrinological investigation
2025

Clinically Nonfunctioning Pituitary Adenomas.

Endocrinology and metabolism clinics of North America
2025

[Spontaneous remission of neuroendocrine diseases due to apoplexy in hormonally active pituitary adenomas].

Problemy endokrinologii
2025

Differences in clinical profiles of patients with symptomatic and asymptomatic apoplexy in pituitary neuroendocrine tumors.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2025

Pituitary apoplexy within a prolactin-secreting macroadenoma in a child: A rare clinical entity with radiological correlation.

Radiology case reports
2026

Hypopituitarism Accompanied with Delusion: The Effects of Growth Hormone Replacement Therapy.

Internal medicine (Tokyo, Japan)
2025

A Comparative Study on Clinical Features, Surgical Outcomes, and Postoperative Complications in Pituitary Apoplexy vs. Non-Apoplexy Patients.

Annali italiani di chirurgia
2025

Gestational Pituitary Apoplexy With Persistent Hypogonadotropic Hypogonadism.

AACE endocrinology and diabetes
2025

Pituitary disorders in pregnancy.

Clinical medicine (London, England)
2025

Pituitary Apoplexy in a Non-Functioning PitNET After Cabergoline Use: Case Report and Review of the Literature.

Journal of clinical medicine
2025

A Case of Spontaneously Resolving Cushing Disease.

JCEM case reports
2025

Pituitary Apoplexy in a Cat With Presumed Acute Diabetes Insipidus.

Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
2025

Pituitary Apoplexy in a Child with Short Stature and Possible Recent SARS-CoV-2 Infection.

Diagnostics (Basel, Switzerland)
2025

Pituitary apoplexy: surgical or conservative? A meta-analytical insight.

Frontiers in surgery
2025

Computed tomographic features of pituitary apoplexy in a cat.

The Journal of small animal practice
2025

Management of Acute Pituitary Apoplexy After Mechanical Aortic Valve Replacement.

JACC. Case reports
2025

Predictors of conversion to surgery in pituitary apoplexy: Insights from a Spanish multicenter observational study.

Journal of clinical &amp; translational endocrinology
2025

Pituitary Apoplexy Following Gonadotropin-Releasing Hormone Agonist Therapy: A Rare and Life-Threatening Complication.

Cureus
2025

Long-term pituitary function following transsphenoidal surgery for non-functional pituitary neuroendocrine tumor with apoplexy: a single-center retrospective analysis.

Scientific reports
2025

Septicemia following sudden pituitary apoplexy after bladder tumor surgery: a case report.

BMC neurology
2025

Pituitary apoplexy in the setting of severe headache and unconsciousness.

BMJ case reports
2025

Pituitary apoplexy, syndrome of inappropriate antidiuretic hormone secretion, and adrenal insufficiency in a 29-year-old male: case report.

CJEM
2025

Cocaine-Induced Apoplexy of a GH-Secreting Pituitary Tumor.

Clinical case reports
2025

Pituitary apoplexy in a patient on antiplatelet therapy: A case report.

Experimental and therapeutic medicine
2025

Endoscopic endonasal transcavernous approach for removal of pituitary macroadenoma with apoplexy: Technical nuances.

Surgical neurology international
2025

COVID-19 induced hypercoagulability and its impact leading to pituitary apoplexy.

JPMA. The Journal of the Pakistan Medical Association
2025

Contemporaneous Presentation of Ocular Myasthenia Gravis With Pituitary Apoplexy: A Diagnostic Dilemma.

Cureus
2025

Recovery of pituitary function in patients with apoplexy immediately after surgical resection of necrotic tumors.

Endocrine
2025

Thyroid-Stimulating Hormone/Growth Hormone Cosecreting Pituitary Adenoma With Normal Thyroid-Stimulating Hormone Level.

JCEM case reports
2025

Predictive factors for early-onset hyponatremia following endoscopic transsphenoidal surgery for nonfunctioning pituitary adenomas.

Journal of neurosurgery
2025

Yellow enhance mode is useful for distinguishing tissues in endoscopic transnasal surgery: case series with preliminary results.

Neurosurgical review
2025

Analysis of diplopia referrals in a tertiary neuro-ophthalmology center.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
2025

Age-related differences in the clinical features and management of pituitary apoplexy: a cohort study.

European journal of endocrinology
2025

Missed diagnosis; non-traumatic retroclival haematoma in adults, brief case report with review and evaluation of similar cases in the literature.

Neurocirugia
2025

Endoscopic endonasal surgery for suprasellar ectopic pituitary neuroendocrine tumors featuring apoplexy and a preoperative differential diagnosis: illustrative cases.

Journal of neurosurgery. Case lessons
2025

Intraoperative venous air embolism during endoscopic transsphenoidal surgery: recommendations for management. Illustrative case.

Journal of neurosurgery. Case lessons
2025

Early surgery is associated with improved postoperative visual outcomes in apoplectic pituitary neuroendocrine tumors with acute visual deterioration.

Neurosurgical review
2025

Pituitary Apoplexy: A Rare but Critical Emergency in Neuroendocrinology.

Cureus
2025

Pituitary Apoplexy Presenting With Oculomotor Nerve Palsy and Headache as the Initial Symptoms: A Case Report.

Clinical case reports
2025

Movement Disorders after Dengue Virus Infection: A Scoping Review.

Movement disorders : official journal of the Movement Disorder Society
2025

What's the bug?: An unusual cause of bacterial meningitis in a patient with history of transsphenoidal surgery.

The American journal of emergency medicine
2025

A retrospective analysis of 338 surgically treated pituitary adenomas.

World neurosurgery
2025

Rathke cleft cyst with squamous metaplasia and activating mutations of mitogen-activated protein kinase signaling: illustrative case.

Journal of neurosurgery. Case lessons
2025

Microprolactinoma Growth During Pregnancy With Pituitary Tumor Apoplexy: Case Report and Review of the Literature.

Case reports in endocrinology
2024

Intrasellar Tuberculosis Presenting as Pituitary Apoplexy: A Case Report.

Cureus
2024

Safety of emergency endoscopic endonasal surgery in COVID-positive patients with hemorrhagic complications of pituitary region tumors: A case report and review of the literature.

Surgical neurology international
2024

Hemorrhagic PitNets Are Associated with Previous Vascular Events and Result in Worse Endocrine Outcome.

Cancers
2024

Trends and Outcomes in Pituitary Apoplexy Management: A Spanish Observational Multicenter Study.

Neurosurgery
2024

Transient cerebral ischemia in pituitary apoplexy-induced internal carotid artery occlusion: illustrative case.

Journal of neurosurgery. Case lessons
2025

Endoscopic Endonasal Approach for Calcified Sellar/Parasellar Region Pathologies: Report of 11 Pituitary Adenoma Cases.

World neurosurgery
2024

Hypopituitarism and COVID-19.

Pituitary
2024

Rathke's cleft cyst apoplexy presented as pituitary apoplexy: A case report.

International journal of surgery case reports
2024

Influence of surgical timing on the visual prognosis of patients suffering from a pituitary apoplexy with visual impairment.

Neurosurgical review
2025

Unveiling postpartum pituitary apoplexy through atypical presentation: A case report and review of literature.

Radiology case reports
2025

Isolated Sixth Cranial Nerve Palsy in Patients with Pituitary Apoplexy.

Journal of neurological surgery. Part A, Central European neurosurgery
2024

The role of intervention timing and treatment modality in visual recovery following pituitary apoplexy: a systematic review and meta-analysis.

Journal of neuro-oncology
2024

Ectopic acromegaly with tumoral range hyperprolactinemia and apoplexy with a dramatic regression of pituitary hyperplasia.

Frontiers in endocrinology
2025

COVID19 infection and vaccination and the risk of pituitary apoplexy: an entangled yarn.

Endocrine
2024

Thyrotroph Hyperplasia Caused by Severe Primary Hypothyroidism Leading to Adrenal Crisis.

JCEM case reports
2024

Hypophysitis in COVID-19: a systematic review.

Pituitary
2024

Case Report: IgG4-Related Disease Presenting With Isolated Hypophysitis.

AACE clinical case reports
2024

THE PLACE OF SURGERY IN THE MANAGEMENT OF PROLACTIN SECRETING ADENOMAS.

Acta endocrinologica (Bucharest, Romania : 2005)
2024

Prolactin deficiency in the context of other pituitary hormone abnormalities : Special issue: hypoprolactinemia: a neglected endocrine disorder.

Reviews in endocrine &amp; metabolic disorders
2024

Pituitary Apoplexy in Pregnancy: Neonatal Implications.

NeoReviews
2024

Giant pituitary macroadenoma with apoplexy presenting with isolated bilateral hypoglossal nerve palsy: illustrative case.

Journal of neurosurgery. Case lessons
2025

Distinct clinical characteristics and prognosis of pediatric-onset growth hormone-secreting pituitary adenoma (GHPA) patients compared to adult-onset patients.

Endocrine
2024

Brain Arteriovenous Malformation Hemorrhage and Pituitary Adenoma in a COVID-19-Positive Patient.

Cureus
2024

A Case of Ischemic Pituitary Apoplexy Secondary to ACTH-Secreting Macroadenoma.

The Neurohospitalist
2025

Pituitary Apoplexy: Comorbidities, Management, and Outcomes-A Spanish Observational Multicenter Study.

The Journal of clinical endocrinology and metabolism
2024

Pituitary apoplexy: a comprehensive analysis of 93 cases across functioning and non-functioning pituitary adenomas from a single-center.

Pituitary
2024

SARS-CoV-2 infection and vaccination in patients with pituitary diseases: the experience of a Brazilian reference center.

Pituitary
2024

Feasibility of Early Surgical Treatment for Adolescent Patients with Prolactinoma: A Case Report and Literature Review.

Medicina (Kaunas, Lithuania)
2024

A Complex Case of Pituitary Apoplexy Mimicking a Stroke: A Case Report With a Review of the Literature.

Cureus
2024

Pituitary apoplexy illustrated.

BMJ case reports
2024

Transnasal Transsphenoidal Approach for a Nine-Year-Old Child With Pituitary Apoplexy: A Case Report.

Cureus
2024

Spontaneous Cushing's Disease Remission Induced by Pituitary Apoplexy.

Cureus
2024

Severe Hyponatremia Secondary to Pituitary Macroadenoma With Internal Hemorrhage in the Postpartum Period: A Case Report.

Cureus
2024

Pituitary Apoplexy: a re-appraisal of risk factors and best management strategies in the COVID-19 era.

Pituitary
2024

Severe hypoglycemia in a diabetic patient with pituitary apoplexy: a case report.

Journal of medical case reports
2024

Aggressive Prolactinoma with Progression to Pituitary Carcinoma: A Case Report.

Endocrine, metabolic &amp; immune disorders drug targets
2024

Pituitary Apoplexy: Description of Medical and Surgical Treatment and Clinical, Visual, and Endocrinological Outcomes During the SARS-CoV-2 Pandemic and Over Three Years.

Cureus
2024

A Non-Secreting Pituitary Adenoma That Changed to a Prolactinoma.

Clinics and practice
2024

Pituitary Apoplexy and the Current Understanding of Its Management: A Meta-Analysis of 908 Patients.

World neurosurgery
2025

Pituitary apoplexy is associated with concurrent or subsequent diagnosis of human immunodeficiency virus.

World journal of otorhinolaryngology - head and neck surgery
2024

Graves' Disease in Hypopituitarism Due to Pituitary Apoplexy.

Endocrine, metabolic &amp; immune disorders drug targets
2024

Successful endoscopic endonasal trans-sphenoidal resection for pituitary macro adenoma with apoplexy in a twin pregnancy: A case report.

Clinical case reports
2024

Pituitary apoplexy after surgery for cervical stump adenocarcinoma: A case report and literature review.

Oncology letters
2024

Pituitary Apoplexy: Pitfalls in Diagnosis.

Journal of community hospital internal medicine perspectives
2024

Presumed Pituitary Apoplexy Resulting in the Spontaneous Resolution of a Pituitary Neuroendocrine Tumor: A Case Report.

Cureus
2024

Pituitary apoplexy: a systematic review of non-gestational risk factors.

Pituitary
2024

A remission of Cushing's disease after pituitary tumour apoplexy.

Endokrynologia Polska
2024

Apoplexy of a giant clival ectopic prolactinoma: A very rare case report.

International journal of surgery case reports
2024

Exploring risk factors of severe pituitary apoplexy: Insights from a multicenter study of 71 cases.

Endocrine
2024

Pituitary apoplexy in cushing's disease: a single center study and systematic literature review.

Pituitary
2024

Successful endonasal transsphenoidal surgery to treat acute internal carotid artery occlusion caused by pituitary apoplexy: Usefulness of arterial spin labeling imaging for emergency decision.

Surgical neurology international
2024

Neurovascular Adverse Effects of Sars-Cov-2 Vaccination.

Drug design, development and therapy
2024

Comparing neuroendocrine recovery between surgical and conservative management in pituitary apoplexy patients: a propensity score-matched analysis.

Neurosurgical review
2024

Clinical presentation and surgical outcomes of very large and giant pituitary adenomas: 80 cases in a cohort study of 306 patients with pituitary adenomas.

Acta neurochirurgica
2024

Pituitary and COVID-19 vaccination: a systematic review.

Pituitary
2024

Pituitary Apoplexy: An Updated Review.

Journal of clinical medicine
2024

Pituitary Apoplexy in Macroadenoma After Minor Surgery: An Unusual Case and Literature Review.

Cureus
2024

Diagnosis and Treatment of Pituitary Apoplexy, A True Endocrine Emergency.

Archives of medical research
2024

SARS-Cov-2 Infection: A New Risk Factor for Pituitary Apoplexy?

Endocrine, metabolic &amp; immune disorders drug targets
2024

A Narrative Review on Neuro-Ophthalmological Manifestations That May Occur during Pregnancy.

Life (Basel, Switzerland)
2024

Secondary normal pressure hydrocephalus following pituitary apoplexy: A case report.

Surgical neurology international
2024

Pituitary apoplexy as the first manifestation of non‑functioning pituitary neuroendocrine tumour.

Endokrynologia Polska
2024

Pituitary Apoplexy Presenting with Isolated Third Nerve Palsy: A Rare Case Report.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
2024

Pituitary apoplexy in acute promyelocytic leukemia.

American journal of hematology
2024

Pituitary Apoplexy After a Major Abdominal Surgery: A Case Report.

Cureus
2024

Primary pituitary tuberculoma with a pituitary apoplexy-like presentation.

Endocrinology, diabetes &amp; metabolism case reports
2024

A Case of Pituitary Apoplexy Following Leuprolide Injection for Prostate Cancer.

Rhode Island medical journal (2013)
2023

Primary Central Nervous System Lymphoma Mimicking the Presentation of Pituitary Apoplexy: A Case Report.

Cureus
2024

Optochiasmatic Cavernomas: Updated systematic review and proposal of a novel classification with surgical approaches.

Neurosurgical review
2023

Pituitary apoplexy as a mimicker of infectious meningitis in an adolescent female patient.

Annals of internal medicine. Clinical cases
2024

Pituitary Macroadenoma with Apoplexy, a Mimicker of Normal Tension Glaucoma (NTG): A Case Report.

Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH
2024

Pituitary apoplexy score, toward standardized decision-making: a descriptive study.

Pituitary
2024

Pituitary apoplexy in endocrinologically silent adenoma during somatostatin analog administration for pancreatic neuroendocrine tumor: A case report.

Neuropathology : official journal of the Japanese Society of Neuropathology
2023

Chemical Meningitis and Syndrome of Inappropriate Antidiuretic Hormone Release (SIADH): A Rare Presentation of Pituitary Adenoma Apoplexy.

European journal of case reports in internal medicine
2023

Radiological features of internal carotid artery occlusion caused by pituitary apoplexy: illustrative case.

Journal of neurosurgery. Case lessons
2024

Surgical vs Nonsurgical Management for Pituitary Apoplexy.

The Journal of clinical endocrinology and metabolism
2023

Machine Learning Approaches to Differentiate Sellar-Suprasellar Cystic Lesions on Magnetic Resonance Imaging.

Bioengineering (Basel, Switzerland)
2023

Pituitary Apoplexy Secondary to Gonadotropin-Releasing Hormone Agonist for Breast Cancer.

JCEM case reports
2023

Pituitary Apoplexy With Transition to Acute Hypophysitis in a Patient With Sars-CoV-2 Pneumonia.

JCEM case reports
2023

Corrigendum: Case report: Ruptured internal carotid artery fusiform aneurysm mimicking pituitary apoplexy after stereotactic radiosurgery.

Frontiers in neurology
2023

Pituitary macroadenoma apoplexy as a rare complication of Bruton tyrosine kinase inhibitor in chronic lymphoid leukaemia.

Chinese neurosurgical journal
2024

Subarachnoid hemorrhage due to pituitary adenoma apoplexy-case report and review of the literature.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2023

The TRH test provides valuable information in the diagnosis of central hypothyroidism in patients with known pituitary disease and low T4 levels.

Frontiers in endocrinology
2023

Secondary headaches in pregnancy and the puerperium.

Frontiers in neurology
2023

Pituitary adenoma presenting as isolated oculomotor nerve palsy.

Surgical neurology international
2023

Pituitary Apoplexy-associated Cerebral Salt Wasting Syndrome: A Case Report and Literature Review.

Clinical therapeutics
2023

Pituitary apoplexy during pregnancy with transsphenoidal resection and intraoperative fetal monitoring: A case report.

Case reports in women's health
2023

Subarachnoid haemorrhage associated with pituitary apoplexy and radiographically occult supraclinoid internal carotid artery aneurysms.

BMJ case reports
2023

Pituitary Apoplexy as a Complication of COVID-19 Infection.

Cureus
2024

A Prospective, Multicenter, Observational Study of Surgical vs Nonsurgical Management for Pituitary Apoplexy.

The Journal of clinical endocrinology and metabolism
2023

Ultra-Early Treatment of Neurosurgical Emergencies with Endoscopic Endonasal Approach: Experience from Three Italian Referral Centers.

Journal of clinical medicine
2023

Pituitary apoplexy associated with bacterial meningitis: Diagnostic dilemma.

Clinical case reports
2023

Case report: Ruptured internal carotid artery fusiform aneurysm mimicking pituitary apoplexy after stereotactic radiosurgery.

Frontiers in neurology
2023

Case report: Giant pituitary neuroendocrine tumor presented along with acute visual loss due to pituitary apoplexy after receiving COVID-19 vaccination.

Frontiers in surgery
2023

Postoperative vasospasm and cerebral infarction in a patient with large pituitary adenoma and cerebral superficial siderosis.

Surgical neurology international
2023

Pituitary Neuroendocrine Tumor: Is It Benign or Malignant?

Brain tumor research and treatment
2024

Acute, Complete, Unilateral Ophthalmoplegia: An Unusual Initial Presentation of Pituitary Apoplexy.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
2023

Isolated Sixth Cranial Nerve Palsy as Initial Presentation of Pituitary Apoplexy: A Case Report.

Cureus
2023

Pituitary Diseases and COVID-19 Outcomes in South Korea: A Nationwide Cohort Study.

Journal of clinical medicine
2023

Infarctive Apoplexy of Previously Healthy Pituitary Glands: A Small Case Series and Literature Review.

Journal of neurological surgery reports
2023

Pituitary Adenoma With Apoplexy Presenting As Unilateral Third Nerve Palsy.

Cureus
2024

Chiasmal Injury in Silent Pituitary Apoplexy Without Evidence of Mass Effect.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
2023

Diagnosis and management of pituitary apoplexy: a Tunisian data.

Chinese neurosurgical journal
2023

Takotsubo syndrome and its linkage to neuroendocrinological disorders: a case report.

Future cardiology
2023

Pituitary Apoplexy in Pregnancy: What do We Know?

Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia
2023

Pituitary Apoplexy Following Elective Total Hip Replacement.

Cureus
2023

Euvolaemic hyponatraemia as a rare first presentation of chronic hypopituitarism.

BMJ case reports
2023

Preventing Postoperative Apoplexy in Giant Pituitary Adenomas using Combined Trans-Sphenoidal and Cranial Surgery.

Neurology India
2023

Natural history of pituitary apoplexy: a long-term follow-up study.

Postgraduate medical journal
2023

Racial and ethnic disparities in the presentation size and timing of pituitary adenomas resected via endoscopic endonasal approach.

International forum of allergy &amp; rhinology
2023

Pituitary apoplexy presenting with acute kidney injury.

Journal of medical case reports
2024

SARS-CoV-2 Infection, A Risk Factor for Pituitary Apoplexy? A Case Series and Literature Review.

Ear, nose, &amp; throat journal
2023

Vision Deficit Due to Pituitary Apoplexy.

Cureus
2023

Surgery as first-line treatment for prolactinoma? Discussion of the literature and results of a consecutive series of surgically treated patients.

Neurosurgical review
2023

Overcoming anaesthetic challenges in a pregnant woman with pituitary apoplexy undergoing endoscopic trans-sphenoidal resection of the pituitary tumour.

BMJ case reports
2023

Challenges of Pituitary Apoplexy in Pregnancy.

Journal of clinical medicine
2023

Immune Thrombocytopenic Purpura Presenting with Pituitary Apoplexy: A Case Report and Literature Review.

Journal of neurological surgery reports
2023

Acromegaly complicated with fulminant pituitary apoplexy: clinical characteristic analysis and review of literature.

Endocrine
2023

The Party Wall: Redefining the Indications of Transcranial Approaches for Giant Pituitary Adenomas in Endoscopic Era.

Cancers
2023

Pituitary apoplexy and cerebral infarction.

BMJ case reports
2023

An unusual presentation of pituitary apoplexy precipitated by dengue haemorrhagic fever in a dialysis patient.

Singapore medical journal
2023

A Case of Pituitary Apoplexy and Cavernous Sinus Syndrome during Hemodialysis.

Case reports in endocrinology
2023

Pituitary Apoplexy After Leuprolide Therapy in a Breast Cancer Patient: A Case Report.

Brain tumor research and treatment
2023

Neurological Adverse Reactions to SARS-CoV-2 Vaccines.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
2023

Antiplatelet and anticoagulation therapy and the risk of pituitary apoplexy in pituitary adenoma patients.

Pituitary
2023

A case of pituitary apoplexy mimicking viral meningitis.

Annals of medicine and surgery (2012)
Ver todos os 1.087 no EuropePMC

Associações

Organizações que acompanham esta doença — pra ter apoio e orientação

Ainda não temos associações cadastradas para Apoplexia da pituitária.

É de uma associação que acompanha esta doença? Fale com a gente →

Comunidades

Grupos ativos de quem convive com esta doença aqui no Raras

Ainda não existe comunidade no Raras para Apoplexia da pituitária

Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.

Tire suas dúvidas

Perguntas, dicas e experiências compartilhadas aqui na página

Participe da discussão

Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.

Fazer login

Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Nivolumab rechallenge after pituitary apoplexy associated with nivolumab plus ipilimumab in a patient with pituitary adenoma and rectal melanoma: a case report and literature review.
    Journal of pharmaceutical health care and sciences· 2026· PMID 41857625mais citado
  2. Severe Headache and Acute Blindness: A Case of Pituitary Apoplexy.
    Clinical case reports· 2026· PMID 41797747mais citado
  3. Cabergoline-Resistant Recurrent Macroprolactinoma During Pregnancy: A Case Report and Review of the Literature.
    Cureus· 2026· PMID 41769506mais citado
  4. Pituitary Apoplexy Following Gonadotropin-Releasing Hormone Agonist Administration for Prostate Cancer.
    IJU case reports· 2026· PMID 41767037mais citado
  5. Differences in clinical course between pituitary apoplexy and non-apoplexy patients with nonfunctioning pituitary neuroendocrine tumors.
    Neurosurgical review· 2026· PMID 41735703mais citado
  6. The emerging role of chemokines and chemokine receptors in the biological and clinical behaviour of pituitary neuroendocrine tumours: An exploratory transcriptomic study.
    J Neuroendocrinol· 2026· PMID 41967485recente
  7. Pituitary Apoplexy With Marked Hyperprolactinemia in a 19-Year-Old Woman: A Case Report of Diagnostic Challenges and Surgical Management.
    Cureus· 2026· PMID 41939625recente
  8. Recurrent pituitary apoplexy: experience from a national registry and review of the literature.
    Ther Adv Endocrinol Metab· 2026· PMID 41919183recente
  9. Risk factors for pituitary apoplexy: a meta-analysis and development of a clinical prediction nomogram.
    Front Neurol· 2026· PMID 41884344recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:95613(Orphanet)
  2. MONDO:0006908(MONDO)
  3. GARD:19287(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q991538(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Apoplexia da pituitária
Compêndio · Raras BR

Apoplexia da pituitária

ORPHA:95613 · MONDO:0006908
Prevalência
Unknown
Herança
Not applicable
CID-10
E23.6 · Outros transtornos da hipófise
CID-11
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0032001
EuropePMC
Wikidata
Wikipedia
Papers 10a
DiscussaoAtiva

Nenhuma novidade ainda. O agente esta monitorando.

0membros
0novidades