Termo genérico para doenças que apresentam inflamação muscular crônica e fraqueza de etiologia desconhecida. Os tipos de miopatia inflamatória idiopática são ainda definidos por critérios clinicopatológicos ou pela presença de certos autoanticorpos.
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Termo genérico para doenças que apresentam inflamação muscular crônica e fraqueza de etiologia desconhecida. Os tipos de miopatia inflamatória idiopática são ainda definidos por critérios clinicopatológicos ou pela presença de certos autoanticorpos.
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[Expression of the melanoma 2-mediated pyroptosis pathway in peripheral blood mononuclear cells of patients with idiopathic inflammatory myopathies].
To detect the expression levels of absence in melanoma 2 (AIM2), cysteine aspartate-specific protease-1 (caspase-1), and gasdermin D (GSDMD) in peripheral blood mononuclear cell (PBMC) of patients with idiopathic inflammatory myopathy (IIM) and to explore their role in the pathogenesis of IIM. A total of 30 IIM patients (IIM group) who visited the Department of Rheumatology and Immunology, General Hospital of Northern Theater Command from May 2020 to June 2022 were recruited. Concurrently, 30 healthy volunteers matched by gender and age were recruited from the hospital's Health Examination Center. Clinical information, biochemical and immunological mar-kers, and venous blood samples were collected from the study subjects. Serum double-stranded DNA (dsDNA) levels were detected by fluorescence quantitative method, and the mRNA expression levels of AIM2, caspase-1, GSDMD, interleukin 1β (IL-1β), and IL-18 in PBMC were detected by reverse transcription quantitative real-time PCR (RT-qPCR). The protein expression levels of AIM2, caspase-1, GSDMD, IL-1β, and IL-18 in PBMC were detected using the Western blot (WB) method, and the serum levels of IL-1β and IL-18 were detected by enzyme-linked immunosorbent assay (ELISA). The IIM group included 10 cases of dermatomyositis (DM), 5 cases of polymyositis (PM), 11 cases of overlap syndrome (OM), and 4 cases of immune-mediated necrotizing myopathy (IMNM). Compared with the healthy control group, the serum levels of dsDNA, IL-1β, and IL-18 were significantly increased in the IIM group and its subgroups (P < 0.05). Except for the fact that there was no statistically significant difference in AIM2 mRNA levels in PBMC of the IMNM subgroup compared to the healthy control group, the expression of AIM2, caspase-1, and GSDMD mRNA was significantly increased in the IIM group and other subgroups (P < 0.05); Except for the comparison of IL-1β mRNA levels in PBMC of the IMNM and OM subgroups with the healthy control group showing no statistical difference, the expression of IL-1β and IL-18 mRNA was significantly increased in the IIM group and other subgroups (P < 0.05); Comparisons between subgroups indicated that the expression of IL-1β mRNA in the DM subgroup was significantly higher than that in the OM and IMNM subgroups, and the expression of IL-18 mRNA in the PM subgroup was significantly higher than that in the DM and OM subgroups (P < 0.05). The expression levels of AIM2, caspase-1, GSDMD, IL-1β, and IL-18 proteins in PBMC of the IIM group and its subgroups were significantly higher than those in the healthy control group (P < 0.05); Comparisons among subgroups revealed that the expression of IL-18 protein in the OM subgroup was significantly higher than that in the PM subgroup (P < 0.05). In the IIM group, the mRNA of caspase-1, GSDMD, and IL-18 showed a positive correlation with AIM2 mRNA, and the protein expression of caspase-1, GSDMD, IL-1β, and IL-18 also showed a positive correlation with AIM2 protein expression. The AIM2 inflammasome-mediated pyroptosis pathway may be involved in the pathogenesis of IIM, providing a theoretical basis for further research on the etiology of IIM and the development of new therapies. 检测特发性炎性肌病(idiopathic inflammatory myopathy,IIM)患者外周血单个核细胞(peripheral blood mononuclear cell,PBMC)中黑色素瘤缺失因子2(absent in melanoma 2,AIM2)及其介导的细胞焦亡通路关键组分——半胱氨酸天冬氨酸蛋白酶1(cysteine aspartate-specific protease-1,caspase-1)和焦孔素蛋白D(gasdermin D,GSDMD)的表达,并探讨其在IIM发病机制中的作用。 招募2020年5月至2022年6月于中国人民解放军北部战区总医院风湿免疫科就诊的30例IIM患者(IIM组),同期于医院体检中心招募30名性别和年龄与IIM患者相匹配的健康志愿者(健康对照组),收集研究对象临床信息、血液生化和免疫标志物,以及静脉血样本。通过荧光定量法检测血清双链DNA(double-stranded DNA,dsDNA)水平,通过实时荧光定量逆转录PCR(reverse transcription quantitative real-time PCR,RT-qPCR)检测PBMC中AIM2、caspase-1、GSDMD、白细胞介素1β(interleukin 1β,IL-1β)和IL-18的mRNA表达水平,应用蛋白免疫印迹法检测PBMC中AIM2、caspase-1、GSDMD、IL-1β和IL-18的蛋白表达水平,应用酶联免疫吸附(enzyme-linked immuno-sorbent assay,ELISA)法检测血清中IL-1β和IL-18的表达水平。 IIM组包含皮肌炎(dermatomyositis,DM,n=10)、多发性肌炎(polymyositis,PM,n=5)、重叠性肌炎(overlap syndrome,OM,n=11)和免疫介导的坏死性肌病(immune-mediated necrotizing myopathy,IMNM,n=4)4个亚组。与健康对照组相比,IIM组及其各亚组的血清中dsDNA、IL-1β和IL-18水平均显著增加(P<0.05)。除IMNM亚组PBMC中AIM2 mRNA与健康对照组差异无统计学意义外,IIM组及其他亚组AIM2、caspase-1和GSDMD mRNA表达均显著增加(P<0.05);除IMNM和OM亚组PBMC中IL-1β mRNA与健康对照组比较差异无统计学意义外,IIM组及其他亚组IL-1β和IL-18 mRNA表达均显著增加(P<0.05);亚组间比较表明,DM亚组PBMC中IL-1β mRNA表达明显高于OM和IMNM亚组,PM亚组IL-18 mRNA表达明显高于DM和OM亚组(P<0.05)。IIM及其各亚组的PBMC中,AIM2、caspase-1、GSDMD、IL-1β和IL-18蛋白的表达水平均显著高于健康对照组(P<0.05);各亚组间比较发现,OM亚组的IL-18蛋白表达显著高于PM亚组(P<0.05)。相关性分析表明,IIM组caspase-1、GSDMD和IL-18 mRNA与AIM2 mRNA呈正相关,caspase-1、GSDMD、IL-1β和IL-18蛋白与AIM2蛋白表达也呈正相关。 AIM2炎性小体介导的细胞焦亡通路可能参与IIM的发病机制,这一结论可以为研究IIM的病因及开发新的治疗方法提供理论基础。
Adverse pregnancy outcomes in adult patients with idiopathic inflammatory myopathy: a systematic review and meta-analysis.
Studies of the impact of idiopathic inflammatory myopathy (IIM) and its pregnancy complications have yielded controversial results. The purpose of this study was to perform a systematic literature review and meta-analysis to evaluate the association between IIM and adverse pregnancy outcomes. PubMed, Embase, and Web of Science databases were searched to identify reports of interest. The databases were searched from establishment to May 15, 2025.Two investigators independently screened literature and extracted data according to inclusion and exclusion criteria. Newcastle-Ottawa Scale was used for quality assessment. A random effects model with inverse-variance weighting was selected to estimate the pooled odds ratio (OR) and 95% confidence interval (CI). Data analysis was carried out using RevMan 5.3. This analysis included five population-based retrospective cohorts, predominantly comprising patients with dermatomyositis or polymyositis; thus, the pooled estimates primarily reflect these subtypes. Compared to non-IIM pregnant women, IIM patients had significantly higher risks of hypertensive disorders of pregnancy (OR: 2.73, 95% CI: 1.76-4.23; I2=70%, Q P=0.01; overall effect P<0.00001) and cesarean section (OR: 2.03, 95% CI: 1.37-3.00; I2=79%, Q P=0.002; overall effect P=0.004). Infants born to IIM mothers also had notably higher rates of preterm birth (OR: 3.71, 95% CI: 2.35-5.85; I2=60%, Q P=0.06; overall effect P<0.00001) and small for gestational age/intrauterine growth restriction (OR: 1.90, 95% CI: 1.03-3.51; I2=43%, Q P=0.15; overall effect P=0.04). Our meta-analysis showed IIM to be associated with increased risk of hypertensive disorders of pregnancy, caesarean section, preterm birth and small for gestational age/intrauterine growth restriction birth, though residual confounding by disease activity and treatment may contribute.
Semi-quantitative analyses of muscle magnetic resonance imaging for pattern recognition in early idiopathic inflammatory myopathies.
Idiopathic inflammatory myopathies (IIM) are a group of autoimmune diseases characterized by skeletal muscle inflammation. Magnetic resonance imaging (MRI) is increasingly used in IIM diagnosis, yet standardized protocols and comprehensive datasets remain limited. This study aimed to characterize MRI findings across IIM subtypes, identify muscle involvement patterns, and assess correlations between imaging abnormalities and clinical severity. In this retrospective cohort study, 34 patients with IIM evaluated between 2012 and 2020 in Düsseldorf and Halle (Germany) were included: Inclusion Body Myositis (IBM, n = 9), Dermatomyositis (DM, n = 5), Polymyositis (PM, n = 6), Anti-Synthetase Syndrome (ASYS, n = 5), and Immune-mediated Necrotizing Myopathy (IMNM, n = 9). Clinical data (autoantibody status, creatine kinase [CK] levels, and muscle strength via Manual-Muscle-Testing-8 [MMT-8]) and muscle MRI findings were analysed. Muscle involvement patterns were characterized, and associations with clinical severity were evaluated using univariate linear regression. MRI abnormalities were evident even in early disease stages (median disease duration: 7 months [IQR: 2-18]). Patterns of muscle involvement differed markedly across IIM subtypes; notably, ASYS and IBM showed minimal involvement of upper extremities. A significant correlation was found between MRI-visible pathology and MMT-8 scores (p = 0.027) as well as CK levels (p = 0.028). MRI reveals subclinical muscle involvement in early IIM and uncovers subtype-specific patterns. Given the heterogeneity of MRI findings, individualized imaging approaches are warranted. While MRI serves as a valuable adjunct in diagnosis and management of IIM, its utility depends on standardized protocols and integration with clinical and laboratory data to enable accurate interpretation and informed decision-making in clinical practice.
Muscle MR Radiomics for Evaluation of Idiopathic Inflammatory Myopathies.
This study aimed to establish a prediction model for Idiopathic Inflammatory Myopathies (IIM) based on the radiomics of verasimus intermedius. 43 IIM patients and 48 control cases were analyzed in the retrospective study. By using the 3D slicer software, 107 radiomics features were obtained for each case. The selection of variables was performed using a two-sample t-test or the Mann-Whitney U test, followed by maximum correlation minimum redundancy (mRMR). Least Absolute Shrinkage and Selection Operator (LASSO) regression was used for dimension reduction. To assess the model performance, the receiver operating characteristic (ROC) curve was plotted. The results showed that 67 features were varying between the IIM cases and control groups (p < 0.05). With the mRMR and LASSO methods, seven features were finally determined. Regarding the radiomics model's performance, it achieved an AUC of 0.983 in the validation data. Muscle MR radiomics is feasible for identifying idiopathic inflammatory myopathy and has the potential to serve as a non-invasive alternative to muscle biopsy.
Global landscape of juvenile dermatomyositis research: a bibliometric analysis.
Juvenile dermatomyositis (JDM) is the most common and severe form of juvenile idiopathic inflammatory myopathy. We conducted a global mapping of the JDM scientific literature to assess publication trends, collaboration patterns, intellectual structure, and emerging priorities. We identified English-language original articles on JDM published between 1976 and 2024 in the Web of Science Core Collection (Science Citation Index Expanded), limited to clinically relevant categories. Bibliometrix and VOSviewer were used to generate key bibliometric indicators. Disruption Index was applied to distinguish disruptive from consolidating work. A total of 1113 articles were published in 201 journals by 5626 researchers. Publication output peaked in 2024, with an annual growth rate of 7.8%. The United States produced the largest number of publications, whereas the United Kingdom achieved the highest time-normalized citation rate. Recent research has increasingly focused on immunological endotyping, myositis-specific antibodies (MSAs), disease activity indices, and registry-based studies. Disruption Index analysis showed that disruptive contributions clustered around epidemiologic baselines, core outcome sets, treatment strategies, and clinical definitions. JDM research has evolved into a measurement-driven, collaborative field focused on immunological profiling and standardized assessment. Strengthening international networks and registry-based designs may further accelerate progress in this rare disease domain. This study presents a comprehensive bibliometric analysis of juvenile dermatomyositis research spanning nearly five decades. The study identifies key publication trends, intellectual structures, and disruptive contributions shaping the field. The findings demonstrate that international collaboration and standardization efforts significantly enhance citation impact and field-wide influence. The study provides a strategic roadmap for future research, emphasizing endotype-based classification, registry integration, and cross-specialty dissemination to accelerate progress in this rare disease.
Publicações recentes
Remission rates and predictors in idiopathic inflammatory myopathy subgroups: Insights from a single-center cohort.
Quantitative spectral computed tomography biomarkers for idiopathic inflammatory myopathy-associated interstitial lung disease: a dual-layer detector computed tomography study.
Efficacy and safety of upadacitinib in refractory interstitial lung disease with idiopathic inflammatory myopathies: a retrospective study.
Immunoprecipitation-mass spectrometry reveals known and novel (NatC, BCS1L) antinuclear antibodies in rheumatoid arthritis.
Clinical characteristics and factors associated with dysphagia in idiopathic inflammatory myopathy: A cross-sectional observational study.
📚 EuropePMC406 artigos no totalmostrando 198
Adverse pregnancy outcomes in adult patients with idiopathic inflammatory myopathy: a systematic review and meta-analysis.
Arthritis care & researchSemi-quantitative analyses of muscle magnetic resonance imaging for pattern recognition in early idiopathic inflammatory myopathies.
Journal of neuromuscular diseasesMuscle MR Radiomics for Evaluation of Idiopathic Inflammatory Myopathies.
Current medical imagingValidating the effectiveness of The International Myositis Assessment and Clinical Studies Group (IMACS) idiopathic inflammatory myopathy cancer screening guidelines in a Singapore cohort.
Clinical and experimental rheumatologyGlobal landscape of juvenile dermatomyositis research: a bibliometric analysis.
Pediatric researchA case of anti-nuclear matrix protein 2 antibody-positive dermatomyositis sine dermatitis with a challenging diagnosis due to the absence of typical skin manifestations.
Modern rheumatology case reportsCAR-T therapy for autoimmune rheumatic diseases: navigating clinical frontiers between breakthroughs and uncertainties.
Clinical and experimental medicineNerandomilast attenuates idiopathic inflammatory myopathy-associated interstitial lung disease via inhibiting proliferation and differentiation of B cells.
Frontiers in immunologyAn interpretable machine learning model integrating clinical and CT radiomic features for the detection of interstitial lung disease in idiopathic inflammatory myopathies.
Arthritis research & therapyHLA variation analysis and autoantigen epitope prediction in idiopathic inflammatory myopathies.
Rheumatology (Oxford, England)Antisynthetase Syndrome Mimicking Pulmonary Infection: A Diagnostic Lesson From County-Managed Hospital.
Clinical case reportsFitbit as an activity monitor in idiopathic inflammatory myopathy: results from a real-world cohort.
Clinical and experimental rheumatologyProphylactic Effect of Trimethoprim-sulfamethoxazole on Severe Infections in Idiopathic Inflammatory Myopathy.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseasesErythematous rash and proximal muscle weakness in a 59-year-old woman: Delayed diagnosis of dermatomyositis in a patient with skin of color.
Journal of the National Medical AssociationAssociation between Oropharyngeal Dysphagia and Subgroups of Patients with Idiopathic Inflammatory Myopathy: A Cross-Sectional Study.
DysphagiaA Rare Case Report of Antisynthetase Syndrome With Progressive Myopathy and Interstitial Lung Disease in a 38-Year-Old Male.
Clinical case reportsAnlotinib ameliorates myositis-associated interstitial lung disease (MAILD) via suppression of the NETs-PI3K/Akt-driven epithelial-mesenchymal transition.
RMD openInterstitial lung disease in systemic autoimmune rheumatic diseases: radiologic and histologic correlations.
Rheumatology advances in practiceDevelopment of enzyme-linked immunosorbent assays for the detection of myositis-specific autoantibodies against signal recognition particle, nuclear matrix protein 2, and small ubiquitin-like modifier activating enzyme.
Modern rheumatologyThe impact of vertebral fractures on pulmonary function tests in patients with interstitial lung disease: a cross-sectional study.
Respiratory researchIdentification of immune-related genes and serum miR-100-5p in idiopathic inflammatory myopathy-related heart failure by integrated bioinformatics analysis and clinical validation.
European journal of medical researchKinematic features of dysphagia in inclusion body myositis.
Neuromuscular disorders : NMDSpontaneous remission in statin-associated HMGCR-positive immune-mediated necrotizing myopathy after statin withdrawal.
Neuromuscular disorders : NMD[Expression of the melanoma 2-mediated pyroptosis pathway in peripheral blood mononuclear cells of patients with idiopathic inflammatory myopathies].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciencesIdiopathic Inflammatory Myopathy With Normal Creatine Kinase Levels in an Elderly Patient: A Diagnostic Challenge.
CureusClinical Characteristics and Evolution of Interstitial Lung Disease in Subtypes of Idiopathic Inflammatory Myositis With Prevalent Lung Manifestation: A Retrospective Analysis.
ACR open rheumatologyHyperglycemia-A Driver of Cutaneous Severity in Dermatomyositis: A Narrative Review.
Journal of clinical medicineA Diagnostic Delay: Respiratory Muscle Weakness in Dermatomyositis Masquerading as Pneumonia.
CureusDifferent faces of anti-melanoma differentiation-associated gene 5 antibody-positive myositis.
ReumatologiaLung ultrasound B-line quantification in CTD-ILD: a cross-sectional single-center observational study.
Scientific reportsAddressing cohort reliance in rare diseases literature: a scoping review of myositis research.
Rheumatology (Oxford, England)Prevalence and early detection of myocarditis in idiopathic inflammatory myopathies: a prospective single-centre study.
Clinical and experimental rheumatologyThe distribution and clinical significance of anti-nuclear antibodies in patients with idiopathic inflammatory myopathy in Southwest China.
Medicina clinicaMulti-kingdom gut microbiota characterization in Chinese patients with idiopathic inflammatory myopathies.
Scientific reportsBaricitinib alleviates myositis-associated interstitial lung disease in mice by inhibiting the NETs-cGAS-STING-EMT axis.
International immunopharmacologyAn Update on Dermatomyositis and Related Inflammatory Myopathies: Cutaneous Clues, Skeletal Muscle Involvement, and Advances in Pathogenesis and Treatment.
Muscles (Basel, Switzerland)CT characterization of idiopathic inflammatory myopathy-associated interstitial lung disease: frontiers to strengthen diagnostic accuracyAuthors' ReplyA Review of Myositis-Associated Interstitial Lung Disease2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Screening and Monitoring of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension.
Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia[Rheumatic disease spectrum and immunological profile of anti-PM/Scl antibodies in idiopathic inflammatory myopathies].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciencesAnti-SRP antibody-positive polymyositis complicated by neuromyelitis optica spectrum disorder: a case report and literature review.
Modern rheumatology case reportsA pilot study of telitacicept in predominantly immune-mediated necrotizing myopathy, retrospective analysis of a monocentric Chinese cohort.
Journal of neurologyTargeted Therapy for Idiopathic Inflammatory Myopathy.
Journal of cachexia, sarcopenia and muscleInhibition of NOX4 attenuates muscle damage and mitochondrial dysfunction in inflammatory myopathy.
Arthritis research & therapyRapidly Progressive Polymyositis With Vasculitis: The Pivotal Role of Histopathology in Diagnosis and Management.
CureusClinical features and prognosis of idiopathic inflammatory myopathy complicated by heart failure with preserved ejection fraction.
Rheumatology (Oxford, England)Circular RNAs and their emerging roles in muscular immune-related diseases.
Frontiers in immunologyPrognostic value of pulmonary vessel-related structures in rapid progression of idiopathic inflammatory myopathy-associated interstitial lung disease: a retrospective study from two centres.
BMJ open respiratory researchClinical Significance of Fractional Exhaled Nitric Oxide (FeNO) Measurements in Juvenile Idiopathic Inflammatory Myopathy-Associated Interstitial Lung Disease.
Pediatric pulmonologyRetrospective analysis of myositis-specific antibody-positive veteran survival between 2011 and 2023.
Clinical rheumatologyInterleukin-33 Promotes Interstitial Lung Disease in Idiopathic Inflammatory Myopathy Via ERK-Mediated Epithelial-Mesenchymal Transition: ERK as a Potential Therapeutic Target.
Arthritis & rheumatology (Hoboken, N.J.)Association of clinical features and myositis-specific antibodies in idiopathic inflammatory myopathy: a retrospective study from southern China.
Frontiers in immunologyJuvenile idiopathic inflammatory myopathies assessment by magnetic resonance imaging: a scoping review of protocols, scoring systems, and applications.
Advances in rheumatology (London, England)Increased prevalence and incidence of statin-associated immune-mediated necrotizing myopathy in Native Americans.
Rheumatology (Oxford, England)Cellular Therapy for Systemic Autoimmune Diseases: New Opportunities for Future Research and Interdisciplinary Collaboration.
ACR open rheumatologyIntegrated metabolomic profiling identifies citrate as novel diagnostic biomarker for Anti-MDA5-Positive dermatomyositis.
Arthritis research & therapySerum carcinoembryonic antigen levels correlate with disease severity and 1-year survival across different interstitial lung diseases subtypes.
Rheumatology (Oxford, England)Unmasking Idiopathic Inflammatory Myopathy: A Case of Proximal Weakness in a Young Male With Co-Occurring Vitamin D Deficiency.
Clinical case reportsDistinct cytokine signature in juvenile dermatomyositis: linking myositis-specific antibodies and clinical manifestations.
CytokineProgressive myalgia as the sole manifestation of cancer-associated myositis: A case report and review of the literature.
Medicine[Frequency of hypogonadism and clinical features of systemic sclerosis and idiopathic inflammatory myopathies in men depending on testosterone levels].
Terapevticheskii arkhivAntisynthetase syndrome causing progressive gait disturbance.
Practical neurologyEmerging therapies in idiopathic inflammatory myopathies: Advances in treatment and future directions.
Best practice & research. Clinical rheumatologyRelapse Rate After Glucocorticoid-Free Remission in Patients With Idiopathic Inflammatory Myopathies and Validation of the International Myositis Assessment and Clinical Studies Group Criteria for Complete Clinical Response and Worsening.
Arthritis & rheumatology (Hoboken, N.J.)Statin-Associated Immune-Mediated Necrotizing Myopathy With Dual Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase (Anti-HMGCR) and Anti-OJ Positivity: A Case Report of Fulminant Weakness and Respiratory Failure.
CureusThe SCRIM score: a clinical tool for cancer risk-stratification in patients with idiopathic inflammatory myopathy.
Arthritis research & therapyLongitudinal change of idiopathic inflammatory myopathy-associated interstitial lung disease on high-resolution computed tomography, a prospective cohort study.
BMC pulmonary medicineClinical, functional, and computed tomographic characterization of idiopathic inflammatory myopathy-associated interstitial lung disease: a retrospective cohort study.
Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e TisilogiaAltered Iron Regulation and the Role of Ferritin Heavy Chain in Dermatomyositis Patients.
Journal of inflammation researchChimeric Antigen Receptor (CAR) T Cell Therapy for Neuromuscular Disorders: A Systematic Review.
CureusEmerging therapies in idiopathic inflammatory myopathies.
Journal of neuromuscular diseasesMixed Multiple Autoimmune Syndrome Type 3 With Coexistence of Primary Biliary Cholangitis, Inflammatory Myopathy, and Chronic Thyroiditis: A Case Report.
CureusThe Clinical Features and Prognosis of Idiopathic and Infection-Triggered Acute Exacerbation of Idiopathic Inflammatory Myopathy-Associated Interstitial Lung Disease: A Preliminary Study.
Diagnostics (Basel, Switzerland)Regaining Gait Independence in Idiopathic Inflammatory Myopathy Patients With Inability to Ambulate.
The Journal of dermatologyAssociation of diastolic dysfunction with myocardial tissue characteristics assessed by multi-parameter cardiac magnetic resonance in patients with idiopathic inflammatory myopathy.
Rheumatology (Oxford, England)Discordance in Patient and Physician's Perception of Disease Activity Among Idiopathic Inflammatory Myopathy Patients: Insights From the COVAD Study.
International journal of rheumatic diseasesWhen Sepsis Is Not Sepsis: A Case Report of Autoimmune Myopathy Masquerading as Postoperative Infection.
CureusClinical-pathologic classification of anti-HMGCR-positive immune-mediated necrotizing myopathy.
Scientific reportsCardiac Magnetic Resonance Imaging Markers in Idiopathic Inflammatory Myopathy: Correspondence.
Annals of Indian Academy of NeurologyClinical characteristics and prognostic analysis of concurrent Pneumocystis jirovecii pneumonia in patients with connective tissue diseases: a retrospective study.
Clinical and experimental rheumatologyDiagnostic challenges of dermatomyositis in a resource-limited setting: a case report.
Journal of medical case reportsIdentification of idiopathic inflammatory myopathy research cohorts using international classification of disease (ICD) codes: A systematic review.
Seminars in arthritis and rheumatismClinical features and recurrence risk prediction model in patients with idiopathic inflammatory myopathies-associated interstitial lung disease: a retrospective study from Ningbo.
Frontiers in medicineIdiopathic inflammatory myopathy associated with Sjögren's disease: features of a distinct clinical entity.
Frontiers in immunologyAntisynthetase Syndrome Masquerading As Psoriasis and Psoriatic Arthritis: A Case Report.
CureusAnti-Melanoma Differentiation-Associated Gene 5 Dermatomyositis With Rapidly Progressive Interstitial Lung Disease Complicated by Pneumothorax, Pneumomediastinum, and Subcutaneous Emphysema: Clinical Course Compared With Reported Cases Worldwide.
CureusIdiopathic Inflammatory Myopathy-Molecular Mechanisms Underlying Its Pathogenesis and Physical Therapy Effects.
International journal of molecular sciencesIsolated Rapidly Progressive Interstitial Lung Disease Without Muscle or Skin Involvement in Idiopathic Inflammatory Myopathy: An Unusual Anti-Mi-2 Antibody Phenotype.
CureusMyopathology and Immune Profile of Granulomatous Myositis in Sarcoid Myopathy.
Neuropathology and applied neurobiologyA Scoping Review of Respiratory Dysfunction in Inclusion Body Myositis.
International journal of rheumatic diseasesBiased Usage of V/D/J Genes and Clonal Diversity in IgG Repertoires Correlates with Disease Activity and Clinical Features in Systemic Autoimmune Diseases.
Immunological investigations[Experiences after CD19-CAR T-cell therapy in non-SLE connective tissue diseases].
Zeitschrift fur RheumatologieCharacterization of Muscle Tissue Cell Diversity and Clinical Implications in Idiopathic Inflammatory Myopathy.
Journal of cachexia, sarcopenia and musclePathogenesis and Treatment of Interstitial Lung Disease Accompanied by Anti-melanoma Differentiation-associated Gene 5-positive Idiopathic Inflammatory Myopathies.
Internal medicine (Tokyo, Japan)Quantitative Imaging Markers on HRCT Predict Rapid Progression and Adverse Events of Patients with Idiopathic Inflammatory Myopathies-Related Interstitial Lung Disease.
International journal of general medicineAssociated factors in the development of rapidly progressive interstitial lung disease in patients with idiopathic inflammatory myopathies: a systematic review and meta-analysis.
Frontiers in immunologyPerformance of sit-to-stand, timed up-and-go, and six-minute walk tests in home and office settings in patients with idiopathic inflammatory myopathy.
Seminars in arthritis and rheumatismComplementary and alternative medicine in dermatomyositis: A scoping review.
JAAD internationalUtilization of Rehabilitation Services After Idiopathic Inflammatory Myopathy Diagnosis: A Retrospective Cohort Assessment in the United States.
The Journal of rheumatologyUsing serum cTnT/CK combined with anti-Ro52 antibodies to screen for myocardial involvement and assess prognosis in idiopathic inflammatory myopathy.
Modern rheumatologyPulmonary Involvement in Patients with Positive Myositis Antibodies in Rheumatology: A Retrospective Monocentric Analysis.
Journal of clinical medicineCo-Occurrence of Anti-Synthetase Syndrome and Sjögren Disease: A Case-Based Review.
Journal of clinical medicineNon-targeted immunosuppressive and immunomodulatory therapies for idiopathic inflammatory myopathies.
The Cochrane database of systematic reviewsDermatomyositis: focus on cutaneous features, etiopathogenetic mechanisms and their implications for treatment.
Seminars in immunopathologyClinical significance of cytoplasmic discrete dots (AC-18) patterns in HEp-2 cell indirect Immunofluorescence: insights from a Taiwanese multicenter study.
Clinica chimica acta; international journal of clinical chemistryThe value of myositis-specific autoantibodies in the diagnosis of idiopathic inflammatory myopathy and tumor risk prediction.
The Journal of international medical researchTargeted immunosuppressive and immunomodulatory therapies for idiopathic inflammatory myopathies.
The Cochrane database of systematic reviewsGenetics of myositis - distinct backgrounds of subtypes.
Journal of human geneticsMuscle strength recovery in patients with idiopathic inflammatory myopathy with different myositis-specific autoantibodies.
Immunological medicineClinicopathological profiling and prognosis of idiopathic inflammatory myopathy overlapping with myasthenia gravis: a retrospective cohort study.
Journal of neurologyValidation of the MCK model for predicting outcomes in myopathy-associated interstitial lung disease: a multicentre MYKO cohort study.
Modern rheumatologyAdvances in the Regulation by Immune Cells of Skeletal Myositis Outcomes.
Aging and diseaseAnti-nuclear matrix protein 2 antibody-positive dermatomyositis associated with smouldering myeloma mimicking anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis: A case of digital gangrene, palmar papules, and scrotal rash.
Modern rheumatology case reportsAnifrolumab in Refractory Juvenile Dermatomyositis.
Pediatric dermatologyClinical Significance and Correlation of Plasma D-Dimer, Fibrinogen, and Cytokines in Idiopathic Inflammatory Myopathy.
International journal of general medicineCoexistence of anti-melanoma differentiation-associated protein 5 and anti-Ro52 antibodies in patients with idiopathic inflammatory myopathy: a retrospective cohort study.
Clinical rheumatologyNXP-2-positive polymyositis associated with scrub typhus.
BMJ case reportsPolymyositis-Induced Atrial Flutter: A Rare and Unexpected Arrhythmia in an Idiopathic Inflammatory Myopathy.
Journal of investigative medicine high impact case reportsThe Prospective Registry Of MyositIS (PROMIS): II. Temporal shifts in causes of death among patients with idiopathic inflammatory myopathies.
Journal of the American Academy of DermatologyN-glycosylation patterns of plasma immunoglobulin G in anti-synthetase syndrome disease.
Frontiers in immunologyThe clinical features and mortality predictors for idiopathic inflammatory myopathies: a retrospective study of 572 patients and the "AIRMT" Score.
Clinical rheumatologyChimeric Antigen Receptor T-cell therapy in systemic autoimmune rheumatic diseases: current insights and future prospects.
Journal of rheumatic diseasesExpert consensus on interstitial lung disease associated with systemic autoimmune diseases. Executive summary.
Revista clinica espanolaIdiopathic Inflammatory Myopathies and Malignancy Screening: A Survey of Current Practices Amongst Canadian Neurologists and Rheumatologists.
Muscle & nerveRuxolitinib in adult dermatomyositis with anti-TIF1γ antibody: a case report and literature review.
Frontiers in immunologyRisk, risk factors, and screening of malignancies in dermatomyositis: current status and future perspectives.
Frontiers in oncologyMuscle Vasculitis: A Novel Delineation of Distinct Subsets of Disease.
ACR open rheumatologyImmune Characterization of a Vietnamese Cohort With Idiopathic Inflammatory Myopathies.
Muscle & nerveCardiac involvement in established idiopathic inflammatory myopathy assessed by cardiac magnetic resonance mapping.
Clinical rheumatologyActivated Dendritic Cell Subsets Characterize Muscle of Inclusion Body Myositis Patients and Correlate with KLRG1+ and TBX21+ CD8+ T cells.
medRxiv : the preprint server for health sciencesDiagnostic value of bronchoalveolar lavage fluid metagenomic next-generation sequencing for pulmonary infections in patients with connective tissue disease: A retrospective study.
Scientific reportsCardiac Magnetic Resonance Imaging Markers in Idiopathic Inflammatory Myopathy - A Prospective Observational Study.
Annals of Indian Academy of NeurologyApplication of a Growth-Rate Model to Enhance Subgroup Identification in Heterogeneous Clinical Courses of the Idiopathic Inflammatory Myopathy-Associated Interstitial Lung Disease and Its Prognostic Implication.
International journal of rheumatic diseasesMyositis Due to Parvovirus B19: A Case Report and Literature Review.
CureusAgeing Signatures and Disturbed Muscle Regeneration in Muscle Proteome of Inclusion Body Myositis.
Journal of cachexia, sarcopenia and muscleA case of myositis associated with mixed connective tissue disease mimicking bilateral posterior interosseous nerve palsy.
Ideggyogyaszati szemleAnalysis of clinical features and risk factors for patients with idiopathic inflammatory myopathy complicated by Pneumocystis jirovecii pneumonia.
Clinical and experimental rheumatologyAssociation of Cancer and Anti-Synthetase Syndrome: A Retrospective Multicenter Study.
The American journal of medicineHigh levels of EPSTI1 enhance IFN-β-mediated HLA-A expression and chemokine secretion in myoblasts in dermatomyositis.
Rheumatology (Oxford, England)Immunoadsorption as a novel therapy for refractory idiopathic inflammatory myopathies: a retrospective observational study.
Rheumatology (Oxford, England)Characterizing local antibody responses in the muscle of inclusion body myositis patients.
Journal of autoimmunityAnti-HMGCR myopathy: a first case report from North Africa and literature insights.
Frontiers in immunologyPolymyositis Presenting With Respiratory Failure and Cardiac Arrest: A Case Report.
CureusBeyond the Generalized Weakness: A Rare Case of Statin-Induced Immune-Mediated Necrotizing Myopathy.
Journal of investigative medicine high impact case reportsInvestigating the profile of patients with idiopathic inflammatory myopathies in the post-COVID-19 period.
Microbiology spectrumDiagnostic performance of particle-based multi-analyte technology compared to indirect immunofluorescence in screening for anti-nuclear antibodies in patients with autoimmune rheumatic diseases.
Clinical and experimental rheumatologySerum connective tissue growth factor is aberrantly expressed in idiopathic inflammatory myopathy.
Clinical and experimental rheumatologyDifferences in Organ Damage Based on Age at Onset in Idiopathic Inflammatory Myopathies: A Retrospective Multicenter MYKO Study.
Internal medicine (Tokyo, Japan)Modeling Idiopathic Inflammatory Myopathy in the Bioinspired Muscle Tissue on Chip.
Advanced healthcare materialsShared and Distinctive Inflammation-Related Protein Profiling in Idiopathic Inflammatory Myopathy with/without Anti-MDA5 Autoantibodies.
Journal of inflammation researchLong-term outcomes of idiopathic inflammatory myopathies: a large-scale longitudinal cohort study.
Journal of autoimmunityMicrovascular abnormalities between anti-TIF1-γ-associated dermatomyositis with and without malignancy.
BMC rheumatologyInclusion Body Myositis: A Case Report.
CureusLocal immune effector cell-associated toxicity syndrome in CAR T-cell treated patients with autoimmune disease: an observational study.
The Lancet. RheumatologyAnti-TIF1-beta autoantibody-positive dermatomyositis: a case-based review.
Rheumatology internationalImaging assessment of calcinosis in juvenile dermatomyositis: a narrative review.
Pediatric rheumatology online journalAbatacept for the treatment of myositis-associated interstitial lung disease.
Rheumatology (Oxford, England)Recruitment rate comparison between a virtual tele-research cohort and a traditional centre-based cohort in idiopathic inflammatory myopathy.
Rheumatology (Oxford, England)A novel approach to refractory idiopathic inflammatory myopathy: CD19 CAR T-cell therapy-case report and literature review.
Rheumatology (Oxford, England)MRI patterns of thigh muscle involvement in immune-mediated necrotizing myopathy and dermatomyositis.
BMC rheumatologyPrevalence of Elevated CK Levels, Myositis-Specific and Myositis-Associated Antibodies, Myositis, and Other Neuromuscular Diseases in Myasthenia Gravis Patients-Experience from an Eastern European Tertiary Center.
Journal of clinical medicineTargeting B Cells for the Treatment of Idiopathic Inflammatory Myopathy.
Clinical reviews in allergy & immunologyPolymorphisms of HSP70 genes are involved in the pathogenesis of idiopathic inflammatory myopathy.
ReumatologiaMitochondrial damage is associated with an early immune response in inclusion body myositis.
Brain : a journal of neurologyThe role of monocytes and macrophages in idiopathic inflammatory myopathies: insights into pathogenesis and potential targets.
Frontiers in immunologySuccessful treatment of rheumatoid arthritis complicated by anti-Jo-1 antibody-positive myopathy with abatacept: A case report.
Fukushima journal of medical scienceRisk factors and predictive model for pulmonary arterial hypertension in adult idiopathic-inflammatory-myopathy patients: A cross-sectional study.
Clinics (Sao Paulo, Brazil)International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening recommendations detect most malignancies in patients with dermatomyositis: Retrospective performance in a tertiary-care center cohort.
Journal of the American Academy of DermatologyMDA5 protein mediating persistent ER stress/unfolded protein response contributes to endothelial-mesenchymal-transition of lung microvascular endothelial cell in dermatomyositis.
Cell communication and signaling : CCSEffectiveness and safety of anti-CD20 monoclonal antibodies versus csDMARDs in anti-Jo-1 antisynthetase syndrome: A retrospective cohort study.
Seminars in arthritis and rheumatismPirfenidone alleviates interstitial lung disease in mice by inhibiting neutrophil extracellular trap formation and NLRP3 inflammasome activation.
Clinical and experimental immunologyNailfold videocapillaroscopy findings are associated with IIM subtypes and IFN activation.
Arthritis research & therapyPseudoangioedema as a presenting symptom of dermatomyositis with antinuclear matrix protein 2 autoantibodies.
JAAD case reportsHuman epididymis secretory protein 4 in idiopathic inflammatory myopathy-associated interstitial lung disease.
Clinical rheumatologyAnti-nuclear Matrix Protein 2 Antibody-Positive Dermatomyositis Relapse With Preceding Panniculitis.
CureusExternal validation of the 2017 EULAR/ACR classification criteria for idiopathic inflammatory myopathies in anti-MDA5 antibody-positive interstitial lung disease patients: A multicenter retrospective cohort study in China.
Seminars in arthritis and rheumatismPlasma levels of adhesion molecules are elevated in dermatomyositis-interstitial lung disease and associated with low paraoxonase-1 activity.
Arthritis research & therapyInterleukin 6 inhibition in refractory antisynthetase syndrome: case-based literature review.
Acta clinica Belgica[Sequential autoimmunity? The rare case of MDA5 dermatomyositis and sarcoidosis].
Zeitschrift fur RheumatologieCorrigendum: Applicability of a serodiagnostic line blot for idiopathic inflammatory myopathy: the muscle biopsy is not all.
Frontiers in neurologyTreatment guidelines for idiopathic inflammatory myopathies in adults: a comparative review.
Rheumatology (Oxford, England)Clinical Features of Dermatomyositis Associated with Myositis-Specific Antibodies in Moroccan Patients.
Clinics and practiceCharacteristics of Overlap Syndrome in a Large Cohort of Brazilian Patients With Systemic Sclerosis: A Retrospective Analysis.
The Journal of rheumatologyPatients with anti-PM/Scl-positive and idiopathic inflammatory myopathy resemble anti-synthetase syndrome.
Advances in rheumatology (London, England)Emerging mechanisms and therapeutics in inflammatory muscle diseases.
Trends in pharmacological sciencesOutcome of COVID-19 in patients with idiopathic inflammatory myopathy during the Omicron wave in China: A longitudinal observational study.
PloS oneMortality Risk Prediction in Patients With Antimelanoma Differentiation-Associated, Gene 5 Antibody-Positive, Dermatomyositis-Associated Interstitial Lung Disease: Algorithm Development and Validation.
Journal of medical Internet researchDermatomyositis following resection of thyroid and breast cancer: a case report and literature review.
Frontiers in oncologycGAS-STING mediates neutrophil extracellular traps-induced EMT in myositis-associated interstitial lung disease: STING as a potential therapeutic target.
International immunopharmacologyMitochondrial transplantation as a novel therapeutic approach in idiopathic inflammatory myopathy.
Annals of the rheumatic diseasesClinical Characteristics and Outcomes of Patients with Anti-MDA5 Antibody Associated Rapidly Progressive Interstitial Lung Disease (RP-ILD): A Case Series.
Mediterranean journal of rheumatologyRetrospective analysis of US veterans with inclusion body myositis: initial findings from the Veterans Affairs Corporate Data Warehouse.
Military Medical ResearchIdiopathic inflammatory myopathy.
Medicina clinica30-Color Longitudinal Full-Spectrum Immunophenotyping and Sorting of Human Circulating Immune Cell Subsets Implicated in Systemic Autoimmune Rheumatic Diseases.
bioRxiv : the preprint server for biologyValidity of Diagnosis Codes to Identify a Dermatomyositis Cohort from Electronic Health Records.
Dermatology (Basel, Switzerland)Recalcitrant Dermatomyositis Treated With Anifrolumab.
ACR open rheumatologyApplicability of a serodiagnostic line blot for idiopathic inflammatory myopathy: the muscle biopsy is not all.
Frontiers in neurologyAnti-SRP myositis: a diagnostic and therapeutic challenge.
The Turkish journal of pediatricsInterstitial Lung Disease Associated with Anti-Ku Antibodies: A Case Series of 19 Patients.
Journal of clinical medicineDisease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry.
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- [Expression of the melanoma 2-mediated pyroptosis pathway in peripheral blood mononuclear cells of patients with idiopathic inflammatory myopathies].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences· 2026· PMID 41633601mais citado
- Adverse pregnancy outcomes in adult patients with idiopathic inflammatory myopathy: a systematic review and meta-analysis.
- Semi-quantitative analyses of muscle magnetic resonance imaging for pattern recognition in early idiopathic inflammatory myopathies.
- Muscle MR Radiomics for Evaluation of Idiopathic Inflammatory Myopathies.
- Global landscape of juvenile dermatomyositis research: a bibliometric analysis.
- Remission rates and predictors in idiopathic inflammatory myopathy subgroups: Insights from a single-center cohort.
- Quantitative spectral computed tomography biomarkers for idiopathic inflammatory myopathy-associated interstitial lung disease: a dual-layer detector computed tomography study.
- Efficacy and safety of upadacitinib in refractory interstitial lung disease with idiopathic inflammatory myopathies: a retrospective study.
- Immunoprecipitation-mass spectrometry reveals known and novel (NatC, BCS1L) antinuclear antibodies in rheumatoid arthritis.
- Clinical characteristics and factors associated with dysphagia in idiopathic inflammatory myopathy: A cross-sectional observational study.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:98482(Orphanet)
- MONDO:0020122(MONDO)
- GARD:9128(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Q55789135(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
