Raras
Buscar doenças, sintomas, genes...
Alopecia universalis
ORPHA:701CID-10 · L63.1CID-11 · ED70.2YOMIM 203655DOENÇA RARA

A forma mais grave de alopecia areata, uma doença inflamatória do folículo piloso, caracterizada pela perda completa de cabelo do couro cabeludo e de todas as áreas do corpo com cabelo.

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Introdução

O que você precisa saber de cara

📋

A forma mais grave de alopecia areata, uma doença inflamatória do folículo piloso, caracterizada pela perda completa de cabelo do couro cabeludo e de todas as áreas do corpo com cabelo.

Pesquisas ativas
5 ensaios
32 total registrados no ClinicalTrials.gov
Publicações científicas
628 artigos
Último publicado: 2026

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
1-5 / 10 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
25.0
Europe
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: L63.1
Você se identifica com essa condição?
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🧬
Pele e cabelo
7 sintomas
👁️
Olhos
2 sintomas
📏
Crescimento
2 sintomas
😀
Face
1 sintomas
🛡️
Imunológico
1 sintomas

+ 4 sintomas em outras categorias

Características mais comuns

100%prev.
Alopecia universal
Muito frequente (99-80%)
100%prev.
Sobrancelha ausente
Muito frequente (99-80%)
100%prev.
Cílios ausentes
Muito frequente (99-80%)
100%prev.
Pelos axilares ausentes
Frequência: 11/11
100%prev.
Pelos pubianos ausentes
Frequência: 11/11
100%prev.
Início neonatal
Frequência: 11/11
17sintomas
Muito frequente (7)
Ocasional (6)
Muito raro (3)
Sem dados (1)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 17 características clínicas mais associadas, ordenadas por frequência.

Alopecia universalAlopecia universalis
Muito frequente (99-80%)100%
Sobrancelha ausenteAbsent eyebrow
Muito frequente (99-80%)100%
Cílios ausentesAbsent eyelashes
Muito frequente (99-80%)100%
Pelos axilares ausentesAbsent axillary hair
Frequência: 11/11100%
Pelos pubianos ausentesAbsent pubic hair
Frequência: 11/11100%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico628PubMed
Últimos 10 anos200publicações
Pico202554 papers
Linha do tempo
2026Hoje · 2026🧪 2001Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

Genes associados

1 gene identificado com associação a esta condição. Padrão de herança: Autosomal recessive, Multigenic/multifactorial.

HRLysine-specific demethylase hairlessDisease-causing germline mutation(s) inTolerante
FUNÇÃO

Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle

LOCALIZAÇÃO

Nucleus

VIAS BIOLÓGICAS (3)
Regulation of lipid metabolism by PPARalphaCytoprotection by HMOX1PPARA activates gene expression
MECANISMO DE DOENÇA

Alopecia universalis congenita

A rare disorder characterized by loss of hair from the entire body. No hair are present in hair follicles on skin biopsy.

EXPRESSÃO TECIDUAL(Ubíquo)
Skin Not Sun Exposed Suprapubic
102.2 TPM
Skin Sun Exposed Lower leg
94.6 TPM
Cerebelo
66.2 TPM
Cérebro - Hemisfério cerebelar
57.0 TPM
Esôfago - Mucosa
31.6 TPM
OUTRAS DOENÇAS (3)
atrichia with papular lesionsalopecia universalis congenitaMarie Unna hereditary hypotrichosis
HGNC:5172UniProt:O43593

Variantes genéticas (ClinVar)

135 variantes patogênicas registradas no ClinVar.

🧬 HR: NM_005144.5(HR):c.2416G>T (p.Glu806Ter) ()
🧬 HR: NM_005144.5(HR):c.2818C>T (p.Arg940Ter) ()
🧬 HR: GRCh37/hg19 8p23.3-21.2(chr8:158049-26626500)x1 ()
🧬 HR: NM_005144.5(HR):c.2367+5G>C ()
🧬 HR: NM_005144.5(HR):c.2978-26A>G ()
Ver todas no ClinVar

Classificação de variantes (ClinVar)

Distribuição de 175 variantes classificadas pelo ClinVar.

44
105
26
Patogênica (25.1%)
VUS (60.0%)
Benigna (14.9%)
VARIANTES MAIS SIGNIFICATIVAS
HR: NM_005144.5(HR):c.3428_3429del (p.Pro1143fs) [Likely pathogenic]
HR: NM_005144.5(HR):c.3199del (p.Arg1067fs) [Likely pathogenic]
HR: NM_005144.5(HR):c.2541G>A (p.Trp847Ter) [Pathogenic]
HR: NM_005144.5(HR):c.974G>A (p.Gly325Asp) [Conflicting classifications of pathogenicity]
HR: NM_005144.5(HR):c.1662C>T (p.Leu554=) [Conflicting classifications of pathogenicity]

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
Aprovado2
3Fase 31
2Fase 211
·Pré-clínico6
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 20 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Alopecia universalis

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

3 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

32 ensaios clínicos encontrados, 5 ativos.

Distribuição por fase
NCT00069589 · Alopecia Areata RegistryAtivo
NCT07406204 · Tofacitinib vs Methotrexate for Severe Alopecia Areata (TOFA…Em breve
PHASE4
NCT07101471 · Rhofanib® (Tofacitinib) Safety and Effectiveness EvaluationConcluído
NCT05589610 · Study of EQ101 in Adult Subjects With Moderate to Severe Alo…Concluído
PHASE2
NCT05098600 · The Epidemiology, Management and Comorbidities in Alopecia A…Concluído
NCT06278402 · Efficacy of Oral Tofacitinib in Moderate to Severe Alopecia …Concluído
PHASE3
NCT04011748 · Clinical Application of Stem Cell Educator Therapy in Alopec…UNKNOWN
PHASE2
NCT03532958 · Phase 2 Trial of BNZ-1 in Patients With Moderate to Severe A…Cancelado
PHASE2
NCT04238091 · Clinical Trial to Evaluate the Efficacy of Fecal Microbiota …Cancelado
PHASE2
NCT03759340 · ATI-502 Topical Solution for the Treatment of Alopecia Areat…Encerrado
PHASE2
NCT04205214 · A Randomised Control Trial of Integrative Cognitive Behaviou…Concluído
NA
NCT03594227 · ATI-501 Oral Suspension Compared to Placebo in Subjects With…Concluído
PHASE2
NCT03315689 · Safety and Pharmacokinetic Study of ATI-50002 in Subjects Wi…Concluído
PHASE2
NCT03551821 · Open Label Study of ATI-50002 Topical Solution Administered …Concluído
PHASE2
NCT02812342 · Topical Tofacitinib for the Treatment of Alopecia Areata and…Concluído
PHASE2
NCT02312882 · Tofacitinib for the Treatment of Alopecia Areata and Its Var…Concluído
NA
NCT02197455 · Tofacitnib for the Treatment of Alopecia Areata and VariantsConcluído
PHASE2
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

📖Melhor nível de evidência: Revisão
Timeline de publicações
339 papers (10 anos)
#1

Stem cell-based therapies for alopecia areata: a narrative review.

Stem cell research &amp; therapy2026 Feb 08

Alopecia Areata (AA) is a chronic inflammatory disorder characterized by non-scarring, patchy hair loss that may progress to the entire scalp (alopecia totalis) or body (alopecia universalis), significantly impairing patients' quality of life and psychological health. Although the exact pathogenesis of AA remains unclear, current evidence suggests that the breakdown of hair follicle immune privilege (IP) and subsequent autoimmune-mediated follicular attack play a pivotal role. Conventional therapeutic modalities, including corticosteroid and Janus kinase (JAK) inhibitors, are often limited by suboptimal efficacy in severe cases and high relapse rates following treatment cessation. In recent years, stem cell-based therapy has emerged as a novel treatment for AA, showing therapeutic potential through multiple mechanisms. Preliminary clinical trials have indicated significant efficacy in promoting hair regrowth among AA patients. However, comprehensive evaluation of long-term safety and therapeutic efficacy remains imperative. This review article aims to give a comprehensive overview of the recent advances in stem cell-based therapies for AA and explore their underlying mechanisms and clinical application prospects, hoping to provide a framework and reference for future research and clinical practice.

#2

Case Report: Vitiligo and Alopecia Universalis Following Rituximab Therapy in a Patient with Myasthenia Gravis.

Clinical, cosmetic and investigational dermatology2026

Rituximab, an anti-CD20 monoclonal antibody, is being used more frequently to treat refractory autoimmune disorders such as myasthenia gravis. While it is usually well tolerated, rare cases of paradoxical immune-mediated skin reactions have been rarely reported. However, the concurrent development of vitiligo and alopecia universalis following rituximab therapy has not been previously described. We report a rare case of simultaneous vitiligo and alopecia universalis developing during long-term treatment with rituximab in a patient with myasthenia gravis and discuss the clinical course and treatment response. This case report describes a 30-year-old woman with myasthenia gravis who developed vitiligo followed by alopecia universalis during a long term of Rituximab therapy. Cutaneous findings included well-demarcated depigmented patches on the trunks and bilateral arms and diffuse non-scarring alopecia affecting the scalp, eyebrows, eyelashes, and body hair, consistent with 100% score of Severity of Alopecia tool (SALT) indicating Alopecia universalis. Rituximab was discontinued due to a possible drug-reaction. Treatment with oral Baricitinib was initiated to target both vitiligo and alopecia universalis. Within three months, there was significant scalp hair regrowth and re-pigmentation of vitiligo patches with minimal adverse effects. This case highlights a unique temporal association of rituximab therapy and the simultaneous onset of vitiligo and alopecia universalis. Although the relationship between the drug and the onset of the skin diseases cannot be established, it is important to be aware of the possibility of immune-related skin adverse effects during rituximab therapy. Early intervention and the use of Janus kinase inhibitors, such as baricitinib, may lead to good clinical outcomes.

#3

From Bald to Bold: Reversal of Alopecia Totalis in an Adolescent Using Dupilumab Monotherapy.

Journal of drugs in dermatology : JDD2026 Mar 01

Alopecia areata (AA) is an autoimmune condition marked by non-scarring, patchy hair loss of the scalp which progresses in &lt;10% of cases to alopecia totalis (AT), which is marked by complete hair loss from the scalp, eyebrows, and eyelashes. AA is prevalent in pediatric patients and is associated with atopic dermatitis (AD). The interleukin (IL)-4 and IL-13 antagonist dupilumab is approved for use in both pediatric and adult patients with AD and asthma. However, in some cases, dupilumab has shown promising results in regrowing hair in patients with concurrent AA. We report a 13-year-old male patient with a past medical history of AD and food atopy, who presented with AA to the scalp. The patient's hormonal lab work-up was within normal limits, and he was treated and failed typical therapies for AA. Within nine months of treatment, the hair loss progressed to AT of the scalp and eyebrows. Dupilumab was then initiated as monotherapy for the patient's AD and AT, leading to regrowth of hair on the scalp and eyebrows within several months and sustained complete hair regeneration after 17 months post dupilumab initiation. This case demonstrates the potential use of dupilumab, which has a well-established safety profile, for pediatric patients with AA and its ability to initiate and sustain hair growth for the long term. Dermatologists may consider dupilumab for patients with AA and comorbid AD that have failed a variety of treatments from several drug classes. &nbsp.

#4

Psoriasis Course in Patients with Alopecia Areata Undergoing Baricitinib Therapy.

Clinics and practice2026 Jan 28

Background/Objectives: Alopecia areata (AA) and psoriasis are immune-mediated diseases that can coexist, suggesting shared pathogenic mechanisms. While Janus kinase inhibitors (JAKi) are approved for AA treatment, their role in managing concomitant psoriasis and psoriatic arthritis (PsA) remains unclear. This study evaluates the efficacy and safety of baricitinib in patients with severe AA and coexisting psoriasis and/or PsA. Materials and Methods: A retrospective case series of five patients (mean age 53.2 years) with severe AA (SALT > 80) or alopecia universalis (AU) and concomitant psoriasis (n = 2) and/or PsA (n = 3) was conducted in the Dermatology Unit of Policlinico of Tor Vergata, Catholic University of the Sacred Heart and La Sapienza University of Rome, Italy. Patients received baricitinib 4 mg/day and were assessed at weeks 4, 24, and 52 using SALT, PASI, and pVAS scores. Results: At week 52, one patient achieved complete AA remission, while two improved to SALT < 20 (mean SALT 83 to 8.75). Psoriasis remained stable (mean PASI 1.4 to 0.5). However, one PsA patient worsened (pVAS 9) and discontinued the treatment. Conclusions: Baricitinib was effective for AA, with potential benefits for psoriasis, but it may not be optimal for PsA. Further studies are needed to define its role in multiple immune diseases.

#5

Clinical characteristics, subtype classification, and prognostic factors of ophiasis: A retrospective study of 150 patients with therapeutic implications.

Journal of the American Academy of Dermatology2026 Feb 21

Ophiasis is an uncommon, clinical heterogeneous, and therapeutically challenging presentation of alopecia areata (AA). Evidence guiding meaningful subtyping and its implications for management remains limited. To characterize the clinical, trichoscopic, and histopathologic features of ophiasis and evaluate a novel subtype classification for prognostic and management relevance. A retrospective study of 150 patients with ophiasis was performed. Clinical, trichoscopic, and histopathologic data were collected and compared with patchy AA, acute diffuse and total alopecia, and alopecia universalis/alopecia totalis cohorts. A novel three-subtype classification of ophiasis based on scalp involvement patterns was proposed and evaluated its prognostic value. Ophiasis showed a female predominance, prolonged disease duration, and lower activity and regrowth rates than other AA subtypes. Trichoscopy demonstrated significant vellus hair involvement, abundant yellow dots, and minimal activity signs, while histopathology revealed minimal inflammation and increased telogen follicles, supporting chronicity. The 3 subtypes-typical ophiasis, ophiasis with patchy AA, and diffuse ophiasis-exhibited markedly different prognoses. Ophiasis with patchy AA showed comparatively favorable regrowth. Subtype classification independently predicted treatment response. Sample size, retrospective design. Ophiasis is chronic and refractory. Our proposed classification system can accurately identify patients with poorer prognosis, guiding early intervention and stratified treatment.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC281 artigos no totalmostrando 198

2026

Case Report: Vitiligo and Alopecia Universalis Following Rituximab Therapy in a Patient with Myasthenia Gravis.

Clinical, cosmetic and investigational dermatology
2026

From Bald to Bold: Reversal of Alopecia Totalis in an Adolescent Using Dupilumab Monotherapy.

Journal of drugs in dermatology : JDD
2026

Regrowth of Eyebrows in a Previous Steroid Non-Responder With Alopecia Universalis After Ritlecitinib Treatment.

Journal of drugs in dermatology : JDD
2026

Psoriasis Course in Patients with Alopecia Areata Undergoing Baricitinib Therapy.

Clinics and practice
2026

Clinical characteristics, subtype classification, and prognostic factors of ophiasis: A retrospective study of 150 patients with therapeutic implications.

Journal of the American Academy of Dermatology
2026

Stem cell-based therapies for alopecia areata: a narrative review.

Stem cell research &amp; therapy
2025

Case Report: Successful treatment of pediatric alopecia universalis with ritlecitinib after failure of baricitinib.

Frontiers in medicine
2025

Erythroderma, Alopecia, Anhidrosis, and Vitiligo as Complications of a Red Ink Tattoo-A Case Report.

Clinics and practice
2025

Remission of Alopecia Areata Post-colectomy in a Patient with Crohn's Disease.

The Journal of clinical and aesthetic dermatology
2025

Immune Cell-Targeting Biologics for Alopecia Areata: A New Paradigm in Precision Medicine.

Skin appendage disorders
2025

[Efficiency and safety of JAK inhibitors for alopecia totalis and alopecia universalis].

Zhonghua yi xue za zhi
2025

[Efficacy and safety of baricitinib treatment in alopecia areata: a retrospective analysis].

Orvosi hetilap
2026

Ritlecitinib: Efficacy of a Novel Therapy for Severe Alopecia Areata in Patients Aged 12 Years and Older.

Actas dermo-sifiliograficas
2025

Episodic Neuropathic-Like Musculoskeletal Pain Associated With Ritlecitinib Therapy in Alopecia Universalis: A Case Report.

Cureus
2025

Efficacy of oral tofacitinib in moderate to severe alopecia areata, totalis and universalis at the tertiary care hospital, Karachi.

JPMA. The Journal of the Pakistan Medical Association
2026

British Association of Dermatologists living guideline for managing people with alopecia areata 2025.

The British journal of dermatology
2025

Alopecia universalis following human papillomavirus vaccine administration: a case report.

Clinical and experimental vaccine research
2025

Real-World Effectiveness of JAK Inhibitors for Alopecia Totalis and Alopecia Universalis: A Single-Center Experience.

Journal of cutaneous medicine and surgery
2026

Successful management of therapy-resistant chronic refractory atopic dermatitis and alopecia universalis with oral tofacitinib in a girl.

The International journal of risk &amp; safety in medicine
2025

Systemic Treatment of Moderate to Severe Alopecia Areata in Adults: Updated Australian Expert Consensus Statement.

The Australasian journal of dermatology
2026

Effectiveness and safety of baricitinib in severe alopecia areata: 48-week results.

Journal of the European Academy of Dermatology and Venereology : JEADV
2025

Duration of current alopecia areata episode predicts the effectiveness of baricitinib in Japanese patients with alopecia areata: a single-center retrospective study.

The Journal of dermatological treatment
2025

Post-COVID-19 Alopecia Universalis: Autoimmune Hair Loss and the Challenge of Relapse Management.

Journal of drugs in dermatology : JDD
2025

Association between alopecia areata and cardiovascular disease: a systematic review and meta-analysis.

Frontiers in immunology
2025

Two pediatric cases of alopecia universalis with concomitant atopic dermatitis successfully treated with baricitinib.

JAAD case reports
2025

Treatment outcomes and considerations for topical immunotherapy in patients with alopecia totalis and alopecia universalis.

Frontiers in medicine
2025

Upadacitinib for Alopecia: Current Evidence and Clinical Insights.

Skin appendage disorders
2024

Vogt-Koyanagi-Harada Disease in which Poliosis and Alopecia Occurred after a Long Period of Time.

Acta dermatovenerologica Croatica : ADC
2025

Atrichia Congenita with Papular Lesions: A Report of Rare Case Showing "Cluster of Stars' Appearance on Dermoscopy".

International journal of trichology
2025

Multiomics Analysis of the Response to Ritlecitinib in Alopecia Areata Subtypes and Correlation With Efficacy.

Allergy
2025

Management of comorbid Crohn's disease and alopecia universalis with upadacitinib and oral minoxidil.

The Journal of dermatological treatment
2025

Combination of oral tofacitinib and oral mini-pulse with betamethasone (T-OMP) for the successful treatment of long-standing alopecia universalis: A real-world experience in a recalcitrant disease.

Indian journal of dermatology, venereology and leprology
2025

Autoimmune Polyglandular Syndrome Type 2 Presentation with Alopecia Universalis, Hashimoto's Disease, and Addison's Disease.

International medical case reports journal
2025

Correlation between increased total serum IgE levels and clinical features in alopecia areata patients.

Frontiers in immunology
2025

Informed clinical decisions by outfoxing human FOXN1 variants.

The Journal of allergy and clinical immunology
2025

Oral minoxidil treatment of alopecia areata.

Journal of the American Academy of Dermatology
2025

Vitamin D and Alopecia Areata: From Mechanism to Therapeutic Implications.

Skin appendage disorders
2025

Assessment of Vascular Circulation in Alopecia Areata Using the FMSF Technique.

Journal of clinical medicine
2025

Efficacy of Oral Tofacitinib in Alopecia Areata, Alopecia Totalis, and Alopecia Universalis.

Cureus
2025

Friend or foe: A systematic review of dupilumab and alopecia areata.

Journal of the American Academy of Dermatology
2025

Rates of Infections, Malignancies, Cardiovascular Outcomes, and Death in Individuals with Hospital-treated Alopecia Areata: A Registry-based Cohort Study in Denmark.

Acta dermato-venereologica
2025

Short-term malignancy risk of JAK inhibitors in severe alopecia areata: a multicenter cohort study.

Archives of dermatological research
2025

Efficacy and safety of tofacitinib in patients with total and universal alopecia- A retrospective evaluation of 69 patients.

Indian journal of dermatology, venereology and leprology
2025

Impact of Janus Kinase Inhibitors on Psychiatric and Sleep Outcomes in Alopecia Areata: A Real-World Multicenter Cohort Study.

International journal of dermatology
2025

The Efficacy of Off-Label Abrocitinib in Alopecia Areata: A Systematic Review.

Journal of cutaneous medicine and surgery
2025

Significant efficacy of tofacitinib from China in the treatment of alopecia areata: a case report.

Frontiers in immunology
2025

Alopecia areata in solid organ transplant recipients: A retrospective analysis.

JAAD international
2025

A First Case of Complete Resolution of Hair Loss in a Patient With Rheumatoid Arthritis and Concomitant Alopecia Universalis Treated With Filgotinib.

International journal of dermatology
2025

Efficacy of baricitinib in moderate alopecia areata, severe alopecia areata, alopecia totalis, and alopecia universalis: A real-world comparative study.

Journal of the American Academy of Dermatology
2025

Alopecia universalis and type 1 diabetes mellitus both successfully controlled with baricitinib in a patient with autoimmune polyglandular syndrome type 3A.

The Journal of dermatology
2025

Evaluation of SALT score severity in correlation with trichoscopic findings in alopecia areata: a study of 303 patients.

Archives of dermatological research
2025

Epidemiology of Pediatric Alopecia Areata.

Pediatric dermatology
2025

Systemic Therapies for Pediatric Alopecia Areata.

Pediatric dermatology
2025

Alopecia Universalis: Never Give Up?

Journal of drugs in dermatology : JDD
2025

Switching JAK inhibitors: evaluating baricitinib's effectiveness in alopecia areata after tofacitinib failure.

Archives of dermatological research
2025

Common variable immunodeficiency 10 due to a novel variant of NFKB2 and presenting as alopecia universalis and vitiligo.

Clinical and experimental dermatology
2024

Unexpected Extensive Hair Whitening Following Baricitinib Treatment for Alopecia Universalis: A Case Report and Mechanistic Insights.

Cureus
2025

Baricitinib-Induced Remission of Alopecia Universalis in a Child with NFKB2-Associated Immune Dysregulation.

Journal of clinical immunology
2024

Alopecia Universalis in a Multiple Sclerosis Patient After Switching From Rituximab to Ocrelizumab: A Case Report.

International journal of rheumatic diseases
2024

Idiopathic Developmental Dysplasia of Hip in a Female Child with a Rare Epidermal Syndrome- A Case Report.

Journal of orthopaedic case reports
2024

Alopecia Areata Following the Use of Belimumab in a Patient with Systemic Lupus Erythematosus and Arthritis Who Responded Well to Baricitinib: A Case Report.

The American journal of case reports
2024

A scoping review of alopecia areata and its relationship to COVID-19 vaccinations.

Archives of dermatological research
2025

Hair regrowth in a patient with alopecia universalis and psoriasis vulgaris during deucravacitinib therapy.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
2024

Sudden improvement of alopecia universalis and psoriatic arthritis while receiving upadacitinib: a case-based review.

Reumatismo
2025

Outcomes of down-titration in patients with severe scalp alopecia areata initially treated with baricitinib 4-mg: Week 152 data from BRAVE-AA2.

Journal of the American Academy of Dermatology
2025

Biallelic pathogenic variants in the LSS gene cause congenital alopecia-cataract syndrome.

The Journal of dermatology
2025

British Association of Dermatologists living guideline for managing people with alopecia areata 2024.

The British journal of dermatology
2024

Efficacy and safety of ritlecitinib, an oral JAK3/TEC family kinase inhibitor, in adolescent and adult patients with alopecia totalis and alopecia universalis.

The Journal of dermatology
2024

Myeloproliferative disorder associated with alopecia universalis.

JAAD case reports
2024

Patterns of misdiagnosis in adults with alopecia areata: an analysis using the NIH's All of Us database.

International journal of dermatology
2025

Comparative investigation of immune-related biomarkers related to alopecia areata subtypes.

Archives of medical science : AMS
2024

Concomitant management of alopecia universalis and ulcerative colitis with upadacitinib.

Internal medicine journal
2024

Assessing a measure for Quality of Life in patients with severe Alopecia Areata: a multicentric Italian study.

Frontiers in public health
2025

Alopecia universalis with IL-12-RB1 and STAT4 mutations effectively treated with upadacitinib.

JAAD case reports
2023

Tofacitinib in the Management of Alopecia Universalis.

International journal of trichology
2023

The Association between Number of Follicular Stelae and Severity and Treatment Response of Alopecia Areata Cases: A Retrospective Study.

International journal of trichology
2024

Tofacitinib in Pediatric Alopecia Areata Totalis and Alopecia Universalis: A Retrospective Analysis From India.

Journal of cutaneous medicine and surgery
2024

Comparison of efficacy and safety of tofacitinib and azathioprine in patients with alopecia areata and variants: a double-blind, randomized controlled trial.

Archives of dermatological research
2024

Successful treatment of severe atopic dermatitis and alopecia universalis with upadacitinib in a 29-year-old male patient.

The journal of allergy and clinical immunology. Global
2024

Emergence of Janus kinase inhibitors led to increase in proportion of severe alopecia areata patients receiving treatment: A retrospective cohort study.

Journal of the American Academy of Dermatology
2023

Treatment Response to Diphenylcyclopropenone in Patients with Alopecia Totalis/Universalis.

International journal of trichology
2024

Diphenylcyclopropenone alleviates trachyonychia in alopecia universalis.

International journal of dermatology
2024

"Hair is your crown and glory" - Black women's experiences of living with alopecia and the role of social support.

Health psychology report
2024

The Epidemiology of Hospital-Treated Alopecia Areata in Denmark, 1995-2016.

Dermatology and therapy
2024

C-reactive protein as a novel biomarker for vitamin D deficiency in alopecia areata.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
2024

Efficacy and safety of topical corticosteroid treatment under occlusion for severe alopecia areata in children: a single-centre retrospective analysis.

Clinical and experimental dermatology
2024

A Real-World Study of Steroid-Free Monotherapy with Tofacitinib in Severe and Therapy-Recalcitrant Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Cases: A Retrospective Analysis.

Indian dermatology online journal
2023

A rare case of alopecia universalis.

The Pan African medical journal
2024

European expert consensus statement on the systemic treatment of alopecia areata.

Journal of the European Academy of Dermatology and Venereology : JEADV
2024

Corneal Transplant Rejection and Alopecia Areata Universalis in a Patient With Severe Atopic Dermatitis on Dupilumab.

Actas dermo-sifiliograficas
2024

Successful Remission with Combination of Diphenylcyclopropenone and Apremilast in Refractory Extensive Alopecia Areata.

International journal of trichology
2023

Alopecia Universalis Treated With Tofacitinib: The Role of JAK/STAT Inhibitors in Hair Regrowth.

Cutis
2023

Intralesional Pentoxifylline Injection Versus Triamcinolone Acetonide in Treating localized Alopecia Areata: A Comparative Study.

The Journal of clinical and aesthetic dermatology
2023

Effective management Alopecia totalis by Ayurveda - A case report.

Journal of Ayurveda and integrative medicine
2023

Rapid hair regrowth in an alopecia universalis patient with deucravacitinib: A case report.

SAGE open medical case reports
2023

The Efficacy and Adverse Effects of Corticosteroid Pulse Therapy in Alopecia Areata: A Review Article.

Dermatology practical &amp; conceptual
2023

The Gut and Skin Microbiome in Alopecia: Associations and Interventions.

The Journal of clinical and aesthetic dermatology
2023

Post-Traumatic Stress Disorder in Patients with Alopecia Areata: A Survey Study in the USA.

Skin appendage disorders
2023

Case report: Dupilumab therapy for alopecia areata in a 4-year-old patient resistant to baricitinib.

Frontiers in medicine
2023

Treatments for alopecia areata: a network meta-analysis.

The Cochrane database of systematic reviews
2023

Alopecia areata: What's new in the epidemiology, comorbidities, and pathogenesis?

Journal of dermatological science
2024

Modified Mediterranean Diet With Anti-Inflammatory Features and Oral Butyrate Supplementation Appears to Have No Effect in Cases of Alopecia Areata Universalis and Totalis: Experience With 20 Patients.

Actas dermo-sifiliograficas
2023

Efficacy of Baricitinib in Patients with Various Degrees of Alopecia Areata Severity: Post-Hoc Analysis from BRAVE AA1 and BRAVE AA2.

Dermatology and therapy
2023

Treatment Patterns for Alopecia Areata in the US.

JAMA dermatology
2023

Survey of pediatric dermatologist views on treatment for alopecia areata.

JAAD international
2023

Hair Loss Profiles and Ritlecitinib Efficacy in Patients with Alopecia Areata: Post Hoc Analysis of the ALLEGRO Phase 2b/3 Study.

Dermatology and therapy
2023

Commonly Associated Disorders with Complete Scalp Alopecia in Early Childhood: A Review.

International journal of trichology
2024

Overall and demographic subgroup incidences of alopecia areata, alopecia totalis, and alopecia universalis in the United States.

Journal of the American Academy of Dermatology
2023

Alopecia Universalis in an Elderly Chinese Man Induced by Sacubitril/Alisartan, a Novel Angiotensin Receptor-Neprilysin Inhibitor.

Journal of inflammation research
2023

Real-World Treatment Patterns among Patients with Alopecia Areata in the USA: A Retrospective Claims Analysis.

Acta dermato-venereologica
2023

Janus kinase inhibitors for alopecia areata.

Journal of the American Academy of Dermatology
2023

Treatment of Alopecia Universalis in a Child with Down Syndrome.

Indian journal of pediatrics
2023

Successful treatment of alopecia universalis with abrocitinib: a case report.

The Journal of dermatological treatment
2023

Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge Review.

Genes
2023

Alopecia universalis after injection of messenger RNA COVID-19 vaccine. A case report.

IDCases
2023

A novel predictive model for the recurrence of pediatric alopecia areata by bioinformatics analysis and a single-center prospective study.

Frontiers in medicine
2023

Incidence Rates of Infections, Malignancies, Thromboembolism, and Cardiovascular Events in an Alopecia Areata Cohort from a US Claims Database.

Dermatology and therapy
2023

Prevalence of autoimmune and inflammatory diseases and mental health conditions among an alopecia areata cohort from a US administrative claims database.

The Journal of dermatology
2023

Sintilimab-induced Alopecia Universalis in a Patient With the Anti-tumor Effect of Complete Remission After Hepatectomy.

Journal of immunotherapy (Hagerstown, Md. : 1997)
2023

A retrospective study on the clinical characteristics and prognosis of alopecia totalis and universalis: An update on prognosis.

The Journal of dermatology
2023

Viral-Induced Rapidly Progressive Alopecia Universalis: A Case Report and Literature Review.

Cureus
2022

The Association between the Number of Follicular Stelae and Severity and Treatment Response of Alopecia Areata Cases: A Retrospective Study.

International journal of trichology
2023

The frequency of fatty liver in patients with alopecia areata: A case-control study.

Journal of cosmetic dermatology
2023

Upadacitinib for Successful Treatment of Alopecia Universalis in a Child: A Case Report and Literature Review.

Acta dermato-venereologica
2023

Successful treatment of concomitant alopecia universalis and Crohn's disease with upadacitinib: A case report.

SAGE open medical case reports
2023

Assessing Patient's Values When Selecting Treatments for Alopecia Areata: A Cross-Sectional Survey Study.

Skin appendage disorders
2023

Possible mechanisms mediating complete regrowth of hair following scalp tattooing in alopecia universalis.

JAAD case reports
2023

Trends in Prevalence and Incidence of Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Among Adults and Children in a US Employer-Sponsored Insured Population.

JAMA dermatology
2023

Overall and Racial and Ethnic Subgroup Prevalences of Alopecia Areata, Alopecia Totalis, and Alopecia Universalis.

JAMA dermatology
2023

A Case Series and Literature Review of Telogen Effluvium and Alopecia Universalis after the Administration of a Heterologous COVID-19 Vaccine Scheme.

Vaccines
2023

Hydroxychloroquine for granuloma annulare: A case report on secondary hair growth in alopecia universalis.

SAGE open medical case reports
2022

Baricitinib effectiveness in patients with alopecia universalis and rheumatoid arthritis.

Italian journal of dermatology and venereology
2023

An impressive case of alopecia universalis after COVID-19 vaccination: a coincidental finding or a consequence?

European review for medical and pharmacological sciences
2023

Alopecia Universalis in an Adolescent Successfully Treated with Upadacitinib-A Case Report and Review of the Literature on the Use of JAK Inhibitors in Pediatric Alopecia Areata.

Dermatology and therapy
2022

Dupilumab as a Therapeutic Approach in Alopecia Universalis.

Cutis
2023

Treatment of moderate-to-severe alopecia areata in adolescents with baricitinib: A retrospective review of 29 patients.

Journal of the American Academy of Dermatology
2022

FOXN1 Gene Considerations in Severe Combined Immunodeficiency Treatment in Children.

Cureus
2023

Complete regrowth of hair following scalp tattooing in a patient with alopecia universalis.

JAAD case reports
2023

Effective treatment of alopecia universalis with oral upadacitinib.

JAAD case reports
2023

Clinical response to oral tofacitinib in pediatric patients with alopecia areata.

JAAD case reports
2023

Epidemiology of alopecia areata in Hispanic/Latinx patients.

Journal of the American Academy of Dermatology
2022

Anxiety, depression, and quality of life in children and adults with alopecia areata: A systematic review and meta-analysis.

Frontiers in medicine
2022

Retrospective evaluation of clinical profile and comorbidities in patients with alopecia areata.

Northern clinics of Istanbul
2023

Treatment of alopecia areata of the beard with baricitinib.

Journal of the American Academy of Dermatology
2022

A Practical Approach to the Treatment of Alopecia Areata.

Indian dermatology online journal
2022

Alopecia Areata: Case report and review of pathophysiology and treatment with Jak inhibitors.

Journal of autoimmunity
2022

Alopecia Universalis after Treatment with Simvastatin and Ezetimibe: Affects on Family.

Arquivos brasileiros de cardiologia
2022

Treatment of longstanding alopecia areata universalis of the eyebrows/facial hair with oral and topical tofacitinib.

Dermatology online journal
2022

Alemtuzumab-induced alopecia universalis and transient accommodation spasm in a patient with multiple sclerosis.

Therapeutic advances in neurological disorders
2022

The Role of Antihistamines and Dupilumab in the Management of Alopecia Areata: A Systematic Review.

Journal of drugs in dermatology : JDD
2022

Real-world experience and long-term evaluation of tofacitinib in refractory alopecia areata: A prospective, open-label, single-center study in Asian Arab population.

Dermatologic therapy
2022

A first case of childhood chronic inflammatory demyelinating polyneuropathy associated with alopecia universalis.

Brain &amp; development
2022

Rituximab-Induced Alopecia Universalis in a Patient With Bullous Pemphigoid.

Journal of drugs in dermatology : JDD
2022

Improvement of atopic dermatitis and alopecia universalis with dupilumab.

Dermatology reports
2022

Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal?

Frontiers in immunology
2023

Assessment of alopecia areata universalis successfully treated with upadacitinib.

International journal of dermatology
2022

Topical diphenylcyclopropenone plus topical 0.5% anthralin versus topical diphenylcyclopropenone alone for the treatment of chronic extensive alopecia areata: A split-scalp, double-blind, controlled study.

International journal of trichology
2022

Alopecia universalis with unusual histopathologic features after vaccination with ChAdOx1 nCoV-19 (AZD1222).

JAAD case reports
2022

Is there a link between alopecia areata and gut?

Journal of cosmetic dermatology
2022

Not just thinning: A case of alopecia universalis after mild COVID-19.

JAAD case reports
2022

Economic Impact of Home-Use versus Office-Use Diphenylcyclopropenone in Extensive Alopecia Areata.

Skin appendage disorders
2022

Successful treatment of chronic severe alopecia areata with abrocitinib.

The Australasian journal of dermatology
2022

Phase 2 randomized, dose-ranging trial of CTP-543, a selective Janus Kinase inhibitor, in moderate-to-severe alopecia areata.

Journal of the American Academy of Dermatology
2022

A case of atopic dermatitis with alopecia universalis in a patient treated with abrocitinib.

JAAD case reports
2022

Defining Severity in Alopecia Areata: Current Perspectives and a Multidimensional Framework.

Dermatology and therapy
2022

All-cause health care resource utilization and costs among adults with alopecia areata: A retrospective claims database study in the United States.

Journal of managed care &amp; specialty pharmacy
2022

Could mean platelet volume be used as a marker for activity and severity index of alopecia areata?

The Turkish journal of pediatrics
2022

Topical bimatoprost in the treatment of eyelash loss in alopecia totalis and universalis: A prospective, open-label study.

Dermatologic therapy
2022

Refractory alopecia universalis associated with dermatomyositis successfully treated with tofacitinib.

Modern rheumatology case reports
2023

A phase 2a randomized vehicle-controlled multi-center study of the safety and efficacy of delgocitinib in subjects with moderate-to-severe alopecia areata.

Archives of dermatological research
2021

Alopecia Universalis Associated with Hyperthyroidism Treated with Azathioprine and Hydroxychloroquine: A Case Report.

JNMA; journal of the Nepal Medical Association
2022

Alopecia universalis improvement following risankizumab in a psoriasis patient.

Journal of the European Academy of Dermatology and Venereology : JEADV
2022

Remission of Alopecia Universalis after 1 Year of Treatment with Dupilumab in a Patient with Severe Atopic Dermatitis.

Skin appendage disorders
2022

Successful Therapy of Alopecia Universalis Using a Combination of Systemic Methotrexate and Corticosteroids and Topical 5% Minoxidil.

Clinical, cosmetic and investigational dermatology
2022

Clinical response to adjunctive platelet-rich plasma injections in a patient with alopecia universalis on oral tofacitinib.

JAAD case reports
2022

Intramuscular Corticosteroid Therapy in the Treatment of Alopecia Areata: A Time-to-Event Analysis.

Drug design, development and therapy
2021

Attenuation of Autoimmune Phenomena in a Patient with Autoimmune Polyglandular Syndrome Type 1.

Case reports in endocrinology
2021

Recovery of Alopecia Universalis with Associated Nail Dystrophy Treated with Tofacitinib: A 6-year-old Child's Case Report.

International journal of trichology
2021

Treatment of alopecia totalis/universalis/focalis with vitamin D and analogs: Three case reports and a literature review.

World journal of clinical pediatrics
2021

Ritlecitinib: an investigational drug for the treatment of moderate to severe alopecia areata.

Expert opinion on investigational drugs
2021

Hair regrowth and maintenance in alopecia universalis patient treated with nonablative Er:YAG laser.

Clinical case reports
2022

Estimation of CD3, CD4, and CD8 in Iraqi patients with alopecia areata and alopecia universalis.

Journal of cosmetic dermatology
2022

Alopecia areata and tofacitinib: a prospective multicenter study from a Saudi population.

International journal of dermatology
2022

The close resemblance between patients with severe alopecia areata and those with cancer: What hair tells us about wellness or grave illness.

Journal of the American Academy of Dermatology
2022

It is all alopecia areata: It is time to abandon the terms alopecia totalis and alopecia universalis.

Journal of the American Academy of Dermatology
2021

Tofacitinib Treatment in Patients With Active COVID-19 Infection.

Cureus
2022

[Hair growth with dupilumab in alopecia areata universalis and atopic dermatitis].

Dermatologie (Heidelberg, Germany)
2021

Dupilumab for the treatment of alopecia areata in children with atopic dermatitis.

JAAD case reports
2021

Hairless Gene Nonsense Mutations in Alopecia Universalis: A Case Report.

Iranian journal of public health
2021

Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management.

Clinical reviews in allergy &amp; immunology
2021

Alopecia Areata: An Autoimmune Disease of Multiple Players.

ImmunoTargets and therapy
2021

Alopecia Universalis Occurring after Alemtuzumab Treatment for Multiple Sclerosis. A Two-Year Follow-Up of Two Patients.

International journal of environmental research and public health
2021

Association of Alopecia Areata With Attention-Deficit/Hyperactivity Disorder Stimulant Medication: A Case-Control Study.

Ochsner journal
2021

Adiponectin as a novel biomarker of disease severity in alopecia areata.

Scientific reports
2021

Atrichia with papular lesions: a differential diagnosis of alopecia universalis not to be missed.

Journal of the European Academy of Dermatology and Venereology : JEADV
2022

A case of HIV-associated generalized syphilitic alopecia mimicking alopecia universalis.

International journal of dermatology
2021

T-Cell-Driven Fibroinflammation Inducing Follicular Dedifferentiation in Alopecia Areata and IgG4-Modified Disease.

The American Journal of dermatopathology
2021

Unexpected hair regrowth in a woman with longstanding Alopecia universalis.

GMS ophthalmology cases
Ver todos os 281 no EuropePMC

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Stem cell-based therapies for alopecia areata: a narrative review.
    Stem cell research &amp; therapy· 2026· PMID 41656280mais citado
  2. Case Report: Vitiligo and Alopecia Universalis Following Rituximab Therapy in a Patient with Myasthenia Gravis.
    Clinical, cosmetic and investigational dermatology· 2026· PMID 41869422mais citado
  3. From Bald to Bold: Reversal of Alopecia Totalis in an Adolescent Using Dupilumab Monotherapy.
    Journal of drugs in dermatology : JDD· 2026· PMID 41779754mais citado
  4. Psoriasis Course in Patients with Alopecia Areata Undergoing Baricitinib Therapy.
    Clinics and practice· 2026· PMID 41744512mais citado
  5. Clinical characteristics, subtype classification, and prognostic factors of ophiasis: A retrospective study of 150 patients with therapeutic implications.
    Journal of the American Academy of Dermatology· 2026· PMID 41730433mais citado
  6. Regrowth of Eyebrows in a Previous Steroid Non-Responder With Alopecia Universalis After Ritlecitinib Treatment.
    J Drugs Dermatol· 2026· PMID 41779753recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:701(Orphanet)
  2. OMIM OMIM:203655(OMIM)
  3. MONDO:0008757(MONDO)
  4. GARD:614(GARD (NIH))
  5. Variantes catalogadas(ClinVar)
  6. Busca completa no PubMed(PubMed)
  7. Artigo Wikipedia(Wikipedia)
  8. Q5075435(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Alopecia universalis
Compêndio · Raras BR

Alopecia universalis

ORPHA:701 · MONDO:0008757
Prevalência
1-5 / 10 000
Herança
Autosomal recessive, Multigenic/multifactorial
CID-10
L63.1 · Alopécia universal
CID-11
Ensaios
5 ativos
Início
All ages
Prevalência
25.0 (Europe)
MedGen
UMLS
C0002171
EuropePMC
Wikidata
Wikipedia
Papers 10a
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