Um astrocitoma anaplásico (um tipo de tumor cerebral astrocítico de grau 3) ou um glioblastoma (um tipo de tumor cerebral astrocítico de grau 4).
Introdução
O que você precisa saber de cara
Um astrocitoma anaplásico (um tipo de tumor cerebral astrocítico de grau 3) ou um glioblastoma (um tipo de tumor cerebral astrocítico de grau 4).
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 10 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 15 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
14 genes identificados com associação a esta condição.
Plays a role in intermediary metabolism and energy production (PubMed:19228619, PubMed:22416140). It may tightly associate or interact with the pyruvate dehydrogenase complex (PubMed:19228619, PubMed:22416140)
Mitochondrion
D-2-hydroxyglutaric aciduria 2
A neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. Both a mild and a severe phenotype exist. The severe phenotype is homogeneous and is characterized by early infantile-onset epileptic encephalopathy and cardiomyopathy. The mild phenotype has a more variable clinical presentation. Diagnosis is based on the presence of an excess of D-2-hydroxyglutaric acid in the urine.
Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activati
Cell membraneNucleusCytoplasm, cytosolCytoplasmic vesicle
Pfeiffer syndrome
A syndrome characterized by the association of craniosynostosis, broad and deviated thumbs and big toes, and partial syndactyly of the fingers and toes. Three subtypes are known: mild autosomal dominant form (type 1); cloverleaf skull, elbow ankylosis, early death, sporadic (type 2); craniosynostosis, early demise, sporadic (type 3).
Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues
CytoplasmNucleusCytoplasm, cytoskeleton, microtubule organizing center, centrosomeMidbodyMembrane
Receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. NELL2 is an endogenous ligand for ROS1. Upon endogenous stimulation by NELL2, ROS1 activates the intracellular signaling pathway and triggers epididymal epithelial differentiation and subsequent sperm maturation (By similarity). May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including
Cell membrane
Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:10521434, PubMed:19935646). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (PubMed:10521434). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity)
Cytoplasm, cytosolPeroxisome
Glioma
Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.
Ligand-activated transcription factor that forms obligate heterodimers with the retinoic acid receptor and acts as a key regulator of biological processes, such as adipocyte differentiation, lipid metabolism, glucose homeostasis and beta-oxidation of fatty acids (PubMed:16150867, PubMed:20829347, PubMed:23525231, PubMed:8702406, PubMed:8706692, PubMed:9065481). Activated by lipid ligands: binds peroxisome proliferators, such as hypolipidemic drugs, and fatty acids, such as prostaglandin J2 metab
NucleusCytoplasm
Filament-forming cytoskeletal GTPase (Probable). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity). Plays a role in sperm head formation during spermiogenesis, potentially via facilitating localization of ACTN4 to cell filaments (PubMed:33228246)
CytoplasmCytoplasm, cytoskeletonCell projection, axonCell projection, dendritePerikaryonCytoplasm, perinuclear regionCytoplasmic vesicle, secretory vesicle, acrosome
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubM
Cell membraneEndoplasmic reticulum membraneGolgi apparatus membraneNucleus membraneEndosomeEndosome membraneNucleusSecreted
Lung cancer
A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) (PubMed:30442762, PubMed:30442766, PubMed:30481304). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes (PubMed:30442762, PubMed:30442766, PubMed:30481304)
Endomembrane systemRecycling endosomeGolgi apparatus
Glioma
Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (P
CytoplasmCytoplasm, cytoskeleton, microtubule organizing center, centrosomeCytoplasm, cytoskeleton, spindleCytoplasm, cytoskeleton, spindle pole
Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferat
Cell membraneCytoplasmic vesicleEndoplasmic reticulumSecreted
Achondroplasia
A frequent form of short-limb dwarfism. It is characterized by a long, narrow trunk, short extremities, particularly in the proximal (rhizomelic) segments, a large head with frontal bossing, hypoplasia of the midface and a trident configuration of the hands. ACH is an autosomal dominant disease.
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated
Nucleus
Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apop
CytoplasmNucleusNucleus, PML bodyEndoplasmic reticulumMitochondrion matrixCytoplasm, cytoskeleton, microtubule organizing center, centrosome
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed:1493333, PubMed:36651806, PubMed:7479976). On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (PubMed:7479976, PubMed:7628694, PubMed:7796813, PubMed:7878466)
CytoplasmNucleus
Ectodermal dysplasia and immunodeficiency 2
A form of ectoderma dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. This form of ectodermal dysplasia is associated with decreased production of pro-inflammatory cytokines and certain interferons, rendering patients susceptible to infection. EDAID2 inheritance is autosomal dominant.
Medicamentos e terapias
Mecanismo: Glutathione reductase inhibitor
Mecanismo: Vascular endothelial growth factor A inhibitor
Mecanismo: Epidermal growth factor receptor erbB1 binding agent
Mecanismo: 20S proteasome inhibitor
Mecanismo: Integrin alpha-V/beta-3 antagonist
Mecanismo: DNA topoisomerase I inhibitor
Mecanismo: Ribonucleoside-diphosphate reductase RR1 inhibitor
Mecanismo: Vascular endothelial growth factor receptor inhibitor
Mecanismo: Stem cell growth factor receptor inhibitor
Mecanismo: Tyrosine-protein kinase ABL inhibitor
Variantes genéticas (ClinVar)
1,875 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 6 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
125 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Astrocitoma de alto grau
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
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Outros ensaios clínicos
423 ensaios clínicos encontrados, 16 ativos.
Publicações mais relevantes
TERT Promoter Methylation in Glioblastoma and its Paradoxical Association with Upregulated Gene Expression.
To evaluate telomerase reverse transcriptase (TERT) promoter hyper-methylation as a potential causative epigenetic alteration of elevated mRNA expression in glioblastoma (GBM). The hyper-methylation and mRNA expression were evaluated by methylation-sensitive high-resolution melting analysis (MS-HRM) and qRT-PCR, respectively. Bioinformatic analysis of The Cancer Genome Atlas (TCGA) database was also performed to obtain similar data. The mechanistic link between the hyper-methylation and mRNA expression was analyzed in vitro in U87MG and LN228 GBM cell lines. A cross-sectional study was conducted. A total of 50 cases of adult hemispheric GBMs (IDH wild type), and five cases of high-grade astrocytoma (IDH mutant, grade 4) (HGA) were included for the study. Eight normal brains (NB) from the autopsy of nonneurological diseases were used as control. The TERT promoter methylation was significantly higher in GBM than NB (Median -19.5% vs 6.8%; P value 0.003). Considering 10% methylation as cutoff, hyper-methylation was detected in 65% of GBM, 60% of HGA, and only in a single case of normal brain. There was a significant positive correlation between the methylation level and mRNA expression (correlation coefficient 0.40; P value 0.002) in the study cohort. In the TCGA database, the methylation status of the probes covering the selected promoter region showed a similar association with gene expression. In vitro treatment of the GBM cell lines with demethylase agent Azacitidine led to a significant reduction in the mRNA level and cell proliferation. Hyper-methylation or mRNA expression did not correlate with overall survival. The present study is the first to assess the TERT promoter methylation status in GBM in an Indian cohort. TERT hyper-methylation is crucially implicated in the pathobiology of GBM by enhancing the gene expression. This epigenetic alteration may be an important therapeutic target, especially with the use of a specific demethylating agent.
High-Grade Astrocytoma With Piloid Features: An Aggressive Clinicogenomic Entity Distinct From Pilocytic Astrocytoma.
High-grade astrocytoma with piloid features (HGAP) has recently emerged as an aggressive glioma entity with distinct molecular alterations, yet its clinicogenomic distinction from pilocytic astrocytoma (PA) remains to be fully elucidated. This study aims to clarify the clinical, pathological, and genomic differences between pediatric PA, adult PA, and HGAP, and to provide evidence supporting the recognition of HGAP as a new, aggressive entity. We retrospectively analyzed 100 genetically and histopathologically confirmed PA cases (87 pediatric, 13 adult) and 25 HGAP cases (all > 19 years old) diagnosed at Seoul National University Hospital between 2015 and 2024. Next-generation sequencing using a brain tumor-specific gene panel and immunohistochemistry evaluation. Pediatric PAs (median age 7 years) were predominantly cerebellar (61%) and showed classic biphasic histology (72%) with frequent KIAA1549-BRAF fusion (72%) and BRAF V600E mutations (13%) and rarely KRAS mutation (2.3%). Adult PAs (median age 35 years), when HGAP was excluded, were less often cerebellar (53.8%) and rarely KRAS mutation (2.3%), more frequently supratentorial (23%) or spinal (15%) than pediatric PAs, and showed a higher incidence of KRAS mutations (23.1%), and more patternless or diffuse oligoastrocytic histology (31%), but did not differ in recurrence rate or prognosis compared to pediatric PA. In contrast, HGAPs predominantly affected adults (median age 53 years, ranges: 19-87 years), frequently involved cerebellum (40%), and exhibited high-grade histopathological features. Molecular profiling revealed HGAPs harbored frequent CDKN2A/B deletions (76%) and mutations of NF1 (64%), ATRX (52%), PTPN11 (28%), FGFR1/FGFR4 (20%), TERTp (16%), and TP53 (16%). Patients with HGAP had significantly shorter progression-free and overall survival compared to both pediatric and adult PA. HGAP represents a clinically aggressive and molecularly distinct high-grade glioma, clearly separable from pediatric and adult PA. Its poor prognosis and unique genetic drivers justify its recognition as a new entity. Accurate molecular profiling is essential for diagnosis and management of these tumors, and the poor survival outcomes observed in HGAP highlight the need for further larger cohort studies to identify optimal therapeutic strategies.
Laser interstitial thermal therapy and adjuvant pembrolizumab in recurrent high-grade astrocytoma: a Phase 1/randomized Phase 2b trial.
Immune checkpoint inhibitors (ICIs) show minimal efficacy in recurrent high-grade astrocytoma (rHGA). Laser interstitial thermal therapy (LITT), a minimally invasive cytoreductive approach, may prime rHGA for ICI response. A phase 1/randomized phase 2b trial (ClinicalTrials.gov: NCT02311582 ) was designed to test pembrolizumab in combination with LITT in patients with rHGA. Nine patients were enrolled in the phase I dose-escalation lead-in study. No dose-limiting toxicities were observed and 200 mg of pembrolizumab every three weeks was determined as the recommended phase 2 dose. The phase 2b study was initially designed to randomize (up to 45) patients 1:1 to either LITT followed by pembrolizumab (LITT + PEM) or non-LITT surgery followed by pembrolizumab (NLS + PEM). Phase 2's primary endpoint was progression-free survival (PFS); secondary endpoints included overall survival (OS), safety, and immune signature. After 21 patients, based on an independent Data and Safety Monitoring Committee request of unscheduled interim review of accumulating efficacy data, randomization stopped as benefit from NLS + PEM appeared limited, and the subsequent 24 patients received LITT + PEM. The pre-specified study endpoints were achieved. Among 39 per-protocol patients, LITT + PEM (n = 33) improved median OS (11.8 versus 5.2 months) and 18-month survival (42% versus 0%) compared to NLS + PEM (n = 6) (hazard ratio [HR] 0.17; 95% confidence interval [CI], 0.06-0.49; P = 0.0002). Median PFS was longer in LITT + PEM (4.5 versus 1.6 months; HR 0.21; 95% CI, 0.08-0.56; P = 0.0006). In an intent-to-treat sensitivity analysis (n = 21), OS (HR 0.29; 95% CI, 0.10-0.88) and PFS (HR 0.30; 95% CI, 0.10-0.87) again favored LITT + PEM (n = 13). Treatment was well tolerated. LITT activated non-classical monocytes, and pembrolizumab unleashed CD8⁺ T cell proliferation, clonal expansion, and coordinated memory T-cell responses. Overall, LITT + PEM is safe and may overcome rHGA immunosuppression to generate antitumor immunity.
Management of glioblastoma intramedullary spinal cord metastasis with advanced intraoperative techniques: a case series and systematic review.
Glioblastoma intramedullary spinal cord metastasis (GISCM) is a rare sequela of high-grade astrocytoma and glioblastoma multiforme (GBM). Discrete intramedullary spinal cord metastases are less common than spinal leptomeningeal spread and may follow a more indolent course. Once identified as GISCM, palliative maximal safe resection of the tumor may be considered to alleviate neurological symptoms. Reports describing the surgical management of these rare lesions, including the use of emerging technologies that may aid in maximal safe resection, are sparse. A further understanding is also required regarding the course of disease and factors contributing to mortality in GISCM. We reviewed the intraoperative management and clinical course of three patients treated for GISCM at our institution between 2015 and 2024. We additionally conducted a PRISMA-guided systematic literature review of PubMed Central, MEDLINE, and Bookshelf databases through May 26th, 2025, including original patient reports of GISCM from cranial astrocytoma or GBM. The disease course, management strategies, and causes of mortality in previously reported cases were analyzed. Our institutional cohort had a mean time to spinal metastasis of 26.2 months from diagnosis of cranial disease (range 17.5-40.5 months), with a mean survival of 9.2 months following maximal safe resection of extramedullary components (range 7-12 months). In two cases, intraoperative Stimulated Raman Histology (SRH) was employed to facilitate the rapid identification of metastatic GBM, thereby influencing surgical strategy. In one case, 5-aminolevulinic acid (5-ALA) was used to differentiate between tumor and spinal cord parenchyma, facilitating maximal safe debulking without neurological injury. Literature review identified 38 prior reported cases of GISCM, with a median time to spinal diagnosis of 11.0 months and a median survival of 3.5 months thereafter. The cause of death in the review cohort often involved multiple factors, and when analyzed for contributing factors to death, 38.7% involved cranial progression, 38.7% involved progression of spinal disease, and 29.0% involved medical complications. Gait ataxia at presentation was associated with shorter survival in review patients, potentially reflecting advanced disease with extramedullary cord compression. GISCM represents an entity distinct from leptomeningeal disease and may be managed in conjunction with recurrent cranial disease. Surgical debulking is a technically feasible strategy that can be safely facilitated using tools employed in the management of intracranial GBM, facilitating maximal safe resection without compromising survival.
Pediatric High-Grade Astrocytoma With Piloid Features: A Comprehensive Literature Review.
High-grade astrocytoma with piloid features (HGAP) is a recently defined central nervous system (CNS) tumor, first introduced into the 2021 World Health Organization (WHO) classification. While predominantly observed in adults, pediatric cases remain rare and poorly characterized. This study aimed to review the epidemiology, clinical features, and molecular profile of pediatric HGAP. A comprehensive review of studies published from 2018 to 2025 was performed to identify methylation-confirmed HGAP cases in patients aged 18 years or younger. Data extracted from studies included subject demographics, tumor location, histological features, molecular alterations, and the implemented treatment sequence. The search identified 17 pediatric cases meeting the inclusion criteria. The median age at diagnosis was 15 years (range: 4-18 years), and a male predilection of approximately twofold was observed. Tumors most commonly arose in the posterior fossa (56.3%). Recurrent molecular alterations included CDKN2A/B loss (75%), FGFR1 mutations or fusions (55.6%), and ATRX loss (45.5%). This review did not identify definitive clinical or histomolecular differences between pediatric and adult HGAP, underscoring the need for further comparative studies. Pediatric HGAP may represent an underrecognized diagnostic entity within the glioma spectrum, emphasizing the critical role of methylation profiling for accurate diagnosis and classification. Retrospective reclassification of histologically and molecularly ambiguous gliomas is warranted and may reveal additional cases. Larger pediatric cohorts are urgently needed to inform clinical management and refine prognostic stratification.
Publicações recentes
The "Azzopardi phenomenon" in high-grade astrocytoma with a PNET-like component.
TERT Promoter Methylation in Glioblastoma and its Paradoxical Association with Upregulated Gene Expression.
High-Grade Astrocytoma With Piloid Features: An Aggressive Clinicogenomic Entity Distinct From Pilocytic Astrocytoma.
Laser interstitial thermal therapy and adjuvant pembrolizumab in recurrent high-grade astrocytoma: a Phase 1/randomized Phase 2b trial.
Management of glioblastoma intramedullary spinal cord metastasis with advanced intraoperative techniques: a case series and systematic review.
📚 EuropePMC139 artigos no totalmostrando 158
TERT Promoter Methylation in Glioblastoma and its Paradoxical Association with Upregulated Gene Expression.
Neurology IndiaHigh-Grade Astrocytoma With Piloid Features: An Aggressive Clinicogenomic Entity Distinct From Pilocytic Astrocytoma.
Journal of Korean medical scienceLaser interstitial thermal therapy and adjuvant pembrolizumab in recurrent high-grade astrocytoma: a Phase 1/randomized Phase 2b trial.
Nature communicationsManagement of glioblastoma intramedullary spinal cord metastasis with advanced intraoperative techniques: a case series and systematic review.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaHeterogeneous DNA methylation and gene expression patterns underly metabolic plasticity in canine astrocytoma-derived stem-like cells.
Frontiers in oncologyTwo-Stage Surgical Management of Intramedullary Holocord Astrocytoma in an Adult: A Case Report and Literature Review.
Current oncology (Toronto, Ont.)Pediatric High-Grade Astrocytoma With Piloid Features: A Comprehensive Literature Review.
Pediatric blood & cancerSingle-cell and spatial transcriptome sequencing analysis reveals characteristics of a unique subpopulation in high-grade IDH-mutant astrocytoma.
Cellular oncology (Dordrecht, Netherlands)Neoadjuvant PD1 blockade with laser interstitial thermal therapy for recurrent high-grade glioma.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia[Molecular Genetic Analysis of Childhood Brain Tumors].
No shinkei geka. Neurological surgeryCase Report: FGFR1 mutation and massive chromosome loss drive malignant transformation of low-grade gliomas.
Frontiers in oncologyImaging features of high-grade astrocytoma with piloid features: A single center case series.
The neuroradiology journalRadiosurgery for recurrent high-grade gliomas: a critical analysis based on a retrospective single-center series.
Neurosurgical reviewAdult pilocytic astrocytomas: challenging the benign paradigm with surgical risks, recurrence dynamics, and molecular insights.
Neurosurgical reviewHigh-grade astrocytoma with piloid features resected with an exoscopic supracerebellar infratentorial approach: illustrative case.
Journal of neurosurgery. Case lessonsDNA methylation analysis reveals an epigenetic signature distinctive of high-grade oligodendroglioma.
Acta neuropathologicaATRX loss in adult gliomas lacking H3 alterations or IDH mutations, an exceptional situation for exceptional diagnoses: the experience of Sainte-Anne hospital.
Acta neuropathologica communicationsA Novel Germline MUTYH Mutation (p.W156∗) in High-Grade Astrocytoma, IDH Mutant.
Human mutationA pineal mass in a 39-year-old woman.
Brain pathology (Zurich, Switzerland)Reclassification of pineal tumor as high-grade astrocytoma with piloid features through methylation profiling: illustrative case.
Journal of neurosurgery. Case lessonsHigh-grade astrocytoma with piloid features: a single-institution case series and literature review.
Acta neuropathologica communicationsHigh-grade astrocytoma with piloid features: case report and systematic review.
Zhurnal voprosy neirokhirurgii imeni N. N. BurdenkoHigh-grade astrocytoma with piloid features: A case report and review of literature.
Surgical neurology internationalHigh-grade astrocytoma in a sheep: clinical, pathology, and genetic investigations.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, IncCanine cystic astrocytomas: 7 cases.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, IncHigh-Grade Astrocytoma With Piloid Features: Case Series and Review of a Recently Described Brain Tumor Entity.
Archives of pathology & laboratory medicineHigh-grade astrocytoma with piloid features in the conus medullaris: a rare presentation of a new World Health Organization diagnosis. Illustrative case.
Journal of neurosurgery. Case lessonsFreiburg Neuropathology Case Conference : Posterior fossa tumour 15 years after microsurgical resection of a cerebellar pilocytic astrocytoma.
Clinical neuroradiologyNovel paediatric case of a spinal high-grade astrocytoma with piloid features in a patient with Noonan Syndrome.
NPJ precision oncologyHigh-grade astrocytoma with piloid features: MRI findings associated with a novel entity.
Radiology case reportsRecurrent symptomatic intracranial hemorrhage in high-grade astrocytoma with piloid features: illustrative case.
Journal of neurosurgery. Case lessonsA High-Grade Glioma, Not Elsewhere Classified in an Older Adult with Discordant Genetic and Epigenetic Analyses.
BiomedicinesThe Role of Radiotherapy, Chemotherapy, and Targeted Therapies in Adult Intramedullary Spinal Cord Tumors.
CancersFractional tumor burden maps increase the confidence of reading brain MR perfusion.
European journal of radiologyAstrocytoma with high-grade features and MYBL1-MMP16 fusion.
Surgical neurology internationalNodular Melanoma in a 53-year-old Male with Glioblastoma Multiforme: A Rare Case Report.
Acta medica PhilippinaObstructive Hydrocephalus Due to Aggressive Posterior Fossa Tumor Exhibiting Histological Characteristics of Pilocytic Astrocytoma in Two Adult Neurofibromatosis Type 1 (NF1) Cases.
CureusHigh-Grade Astrocytoma with Piloid Features: A Dual Institutional Review of Imaging Findings of a Novel Entity.
AJNR. American journal of neuroradiologyFreiburg Neuropathology Case Conference: : 68-Year-Old Patient with Slurred Speech, Double Vision, and Increasing Gait Disturbance.
Clinical neuroradiologyA fusion model integrating magnetic resonance imaging radiomics and deep learning features for predicting alpha-thalassemia X-linked intellectual disability mutation status in isocitrate dehydrogenase-mutant high-grade astrocytoma: a multicenter study.
Quantitative imaging in medicine and surgeryA Teenage Boy With a Radiation-Induced High-Grade Astrocytoma.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology SocietyA new subtype of diffuse midline glioma, H3 K27 and BRAF/FGFR1 co-altered: a clinico-radiological and histomolecular characterisation.
Acta neuropathologicaDiagnostic Insights into Pediatric Pleomorphic Xanthoastrocytoma through DNA Methylation Class and Pathological Diagnosis Analysis.
Diagnostics (Basel, Switzerland)Systemic Metastasis of Pediatric Diffuse High-grade Astrocytoma: A Case Report.
NMC case report journal[Circumscribed Astrocytic Gliomas].
No shinkei geka. Neurological surgeryProton MR spectroscopy shows improved performance to segregate high-grade astrocytoma subgroups when defined with the new 2021 World Health Organization classification of central nervous system tumors.
European radiologyInfant-type hemispheric glioma occurring at the cervicomedullary region in a 5-month-old infant: A case report with a special emphasis on molecular classification.
Surgical neurology internationalMolecular profiling of pre- and post-treatment pediatric high-grade astrocytomas reveals acquired increased tumor mutation burden in a subset of recurrences.
Acta neuropathologica communicationsQuality by design engineered, enhanced anticancer activity of temozolomide and resveratrol coloaded NLC and brain targeting via lactoferrin conjugation in treatment of glioblastoma.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.VMET fusions and splicing variants is a strong adverse prognostic factor in astrocytoma, isocitrate dehydrogenase mutant.
Brain pathology (Zurich, Switzerland)Medullary brainstem gliomas in an adult: A rare case report and challenging tumor.
Surgical neurology internationalEstablishment and characterization of two novel patient-derived lines from canine high-grade glioma.
Veterinary and comparative oncologyRisk factor analysis and nomogram establishment and verification of brain astrocytoma patients based on SEER database.
Scientific reportsPhase II Investigation of TVB-2640 (Denifanstat) with Bevacizumab in Patients with First Relapse High-Grade Astrocytoma.
Clinical cancer research : an official journal of the American Association for Cancer ResearchA clinical case report of Balamuthia granulomatous amoebic encephalitis in a non-immunocompromised patient and literature review.
BMC infectious diseasesThe Use of Caffeine Citrate for Respiratory Stimulation in Acquired Central Hypoventilation Syndrome: A Case Series.
Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)An unexpected diagnosis of malignant supratentorial intraparenchymal cystic meningioma mimicking high-grade glioma: case report and literature review.
Journal of surgical case reportsClinical, histological, and molecular features of gliomas in adults with neurofibromatosis type 1.
Neuro-oncologyA rare, giant, anaplastic oligodendroglioma.
Radiology case reportsMulti-ancestry genome-wide association study of 4069 children with glioma identifies 9p21.3 risk locus.
Neuro-oncologyTransdural Skull Base Infiltration by Glioblastoma: Case Report and Review of the Literature.
Case reports in otolaryngologyIntegrative analysis of small non-coding RNAs predicts a piRNA/miRNA-CCND1/BRAF/HRH1/ATXN3 regulatory circuit that drives oncogenesis in glioblastoma.
Molecular omicsRecurrent high-grade astrocytoma with somatic mosaicism of isocitrate dehydrogenase gene mutation.
Pathology internationalLeptomeningeal metastases and dural spread in adult high-grade astrocytomas.
Journal of neuropathology and experimental neurologyCerebellar High-Grade Glioma: A Translationally Oriented Review of the Literature.
CancersImmunohistochemical Expression of PD-L1 and IDH1 with Detection of MGMT Promoter Methylation in Astrocytoma.
Asian Pacific journal of cancer prevention : APJCPCell signaling activation and extracellular matrix remodeling underpin glioma tumor microenvironment heterogeneity and organization.
Cellular oncology (Dordrecht, Netherlands)A High Grade Astrocytoma with Pilocytic Morphology in a 5-Month-Old American Bulldog.
Veterinary sciencesExpanded analysis of high-grade astrocytoma with piloid features identifies an epigenetically and clinically distinct subtype associated with neurofibromatosis type 1.
Acta neuropathologicaIntegrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas.
Acta neuropathologica communicationsThe utility of DNA methylation analysis in elderly patients with pilocytic astrocytoma morphology.
Journal of neuro-oncologyMultiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1.
Acta neuropathologicaPatients' Survival with Astrocytoma After Treatment: a Systematic Review and Meta-analysis of Clinical Trial Studies.
Indian journal of surgical oncologyMulti-institutional study of the frequency, genomic landscape, and outcome of IDH-mutant glioma in pediatrics.
Neuro-oncologyCircumscribed astrocytic gliomas: Contribution of molecular analyses to histopathology diagnosis in the WHO CNS5 classification.
Indian journal of pathology & microbiologyA Case Report of Pediatric Germinoma With SARS-CoV-2: Lessons Learned From an Academic Tertiary Referral Hospital in Asian COVID Epicentrum.
International journal of surgery case reportsEuropean Mistletoe (Viscum album) Extract Is Cytotoxic to Canine High-Grade Astrocytoma Cells In Vitro and Has Additive Effects with Mebendazole.
Veterinary sciencesCircular RNA Sequencing Reveals Serum Exosome Circular RNA Panel for High-Grade Astrocytoma Diagnosis.
Clinical chemistryHigh-grade Astrocytoma Responsible for Optic Nerve Infiltration With Vitreous Seeding.
JAMA ophthalmologyIncidence and survival for childhood central nervous system tumours in Australia, 1983-2016.
Journal of neuro-oncologyClinical-pathological study of 28 glial and mixed neuronal-glial tumors diagnosed within the first year of life.
Clinical neuropathologyClinicoradiological characteristics of primary spinal cord H3 K27M-mutant diffuse midline glioma.
Journal of neurosurgery. SpineMolecular diagnostics helps to identify distinct subgroups of spinal astrocytomas.
Acta neuropathologica communicationsSpinal cord glioblastoma multiforme in a patient with Noonan syndrome: A clinical report.
Clinical neurology and neurosurgeryOvercoming the Challenges in the Treatment of Glioblastoma via Nanocarrier- based Drug Delivery Approach.
Current pharmaceutical designLPA1 Receptor Promotes Progesterone Receptor Phosphorylation through PKCα in Human Glioblastoma Cells.
CellsDiffusion MRI in Evaluation of Pediatric Posterior Fossa Tumors.
Asian Pacific journal of cancer prevention : APJCPHigh-grade astrocytoma with piloid features (HGAP): the Charité experience with a new central nervous system tumor entity.
Journal of neuro-oncologyAn immunohistochemical study of HER2 expression in primary brain tumors.
BioMedicinePhase I Study of Zotiraciclib in Combination with Temozolomide for Patients with Recurrent High-grade Astrocytomas.
Clinical cancer research : an official journal of the American Association for Cancer ResearchMolecular landscape of IDH-mutant primary astrocytoma Grade IV/glioblastomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, IncCanine Gliomatosis Cerebri: Morphologic and Immunohistochemical Characterization Is Supportive of Glial Histogenesis.
Veterinary pathology[Visual fluorescence combined with laser spectroscopy in surgery for intramedullary spinal cord tumors].
Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko＜Editors' Choice＞ Impact of maintenance of postoperative performance status on survival in elderly patients over 70 with high-grade astrocytoma.
Nagoya journal of medical scienceLabel-free multiphoton imaging allows brain tumor recognition based on texture analysis-a study of 382 tumor patients.
Neuro-oncology advancesNuclear Respiratory Factor 1 (NRF1) Transcriptional Activity-Driven Gene Signature Association with Severity of Astrocytoma and Poor Prognosis of Glioblastoma.
Molecular neurobiologyDevelopment of transient radioresistance during fractionated irradiation in vitro.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and OncologyUse of High-Dose Chemotherapy in Front-Line Therapy of Infants Aged Less Than 12 Months Treated for Aggressive Brain Tumors.
Frontiers in pediatricsTextiloma Mimicking a Recurrent High-Grade Astrocytoma: A Case Report.
Journal of neurological surgery reportsNocardia farcinica meningitis in a patient with high-grade astrocytoma.
Journal of infection in developing countriesRBL1 (p107) functions as tumor suppressor in glioblastoma and small-cell pancreatic neuroendocrine carcinoma in Xenopus tropicalis.
OncogeneTranscription factors NFIA and NFIB induce cellular differentiation in high-grade astrocytoma.
Journal of neuro-oncologySignificance of Amphiregulin (AREG) for the Outcome of Low and High Grade Astrocytoma Patients.
Journal of CancerUsefulness of [11C] Methionine PET in the Differentiation of Tumefactive Multiple Sclerosis from High Grade Astrocytoma.
Neurologia medico-chirurgicaClinicopathological characteristics of circumscribed high-grade astrocytomas with an unusual combination of BRAF V600E, ATRX, and CDKN2A/B alternations.
Brain tumor pathologyProliferation-dominant high-grade astrocytoma: survival benefit associated with extensive resection of FLAIR abnormality region.
Journal of neurosurgeryRegorafenib in patients with recurrent high-grade astrocytoma.
Journal of cancer research and clinical oncologyReliability of Imaging-Based Diagnosis of Lateral Ventricular Masses in Children.
World neurosurgeryTrajectories of psychosocial and cognitive functioning in pediatric patients with brain tumors treated with radiation therapy.
Neuro-oncologySupratentorial high-grade astrocytoma with leptomeningeal spread to the fourth ventricle: a lethal dissemination with dismal prognosis.
Journal of neuro-oncologyA Rare Case of Metastases from a High-grade Astrocytoma to the Pleura, Bones, and Liver within Six Months of Diagnosis.
CureusDurable Response to Nivolumab in a Pediatric Patient with Refractory Glioblastoma and Constitutional Biallelic Mismatch Repair Deficiency.
The oncologistNonmeasurable Speckled Contrast-Enhancing Lesions Appearing During Course of Disease Are Associated With IDH Mutation in High-Grade Astrocytoma Patients.
International journal of radiation oncology, biology, physicsDifferential Diagnosis between Low-Grade and High-Grade Astrocytoma Using System A Amino Acid Transport PET Imaging with C-11-MeAIB: A Comparison Study with C-11-Methionine PET Imaging.
Contrast media & molecular imagingMR Imaging Features of Anaplastic Pleomorphic Xanthoastrocytoma Mimicking High-Grade Astrocytoma.
AJNR. American journal of neuroradiologyGene expression microarray analysis reveals prognostic markers of survival in high grade astrocytomas.
Neurological researchEvaluation of high-grade astrocytoma recurrence patterns after radiotherapy in the era of temozolomide: A single institution experience.
Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation OncologyCerebellar high-grade astrocytoma with IDH mutations in the elderly: A report of two cases.
Neuropathology : official journal of the Japanese Society of NeuropathologyVessel Morphologies of the Brain in Cytological Squash Preparations Are Useful for Intraoperative Diagnosis of High-Grade Astrocytomas.
Acta cytologicaGlioblastoma Multiforme in a Patient with Multiple Myeloma: A Case Report and Literature Review.
The Permanente journalDiagnostic Performance of Arterial Spin Labeling for Grading Nonenhancing Astrocytic Tumors.
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in MedicineIDH1 R132H Mutation Is Accompanied with Malignant Progression of Paired Primary-Recurrent Astrocytic Tumours.
Journal of CancerLong-term daily temozolomide with dose-dependent efficacy in MGMT promotor methylation negative recurrent high-grade astrocytoma.
Cancer chemotherapy and pharmacologySerial changes in lymphocyte subsets in patients with newly diagnosed high grade astrocytomas treated with standard radiation and temozolomide.
Journal of neuro-oncologyGene Expression Profiling of Chemokines and Their Receptors in Low and High Grade Astrocytoma.
Asian Pacific journal of cancer prevention : APJCP[Clinical effects of microsurgery in spinal cord anaplastic astrocytoma].
Zhonghua wai ke za zhi [Chinese journal of surgery]A pediatric trial of radiation/cetuximab followed by irinotecan/cetuximab in newly diagnosed diffuse pontine gliomas and high-grade astrocytomas: A Pediatric Oncology Experimental Therapeutics Investigators' Consortium study.
Pediatric blood & cancerEpigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas.
GenesHigh ATP2A2 expression correlates with better prognosis of diffuse astrocytic tumor patients.
Oncology reportsA case of high-grade astrocytoma with BRAF and ATRX mutations following a long-standing course over two decades.
Neuropathology : official journal of the Japanese Society of NeuropathologyMiddle Temporal Gyrus Versus Inferior Temporal Gyrus Transcortical Approaches to High-Grade Astrocytomas in the Mediobasal Temporal Lobe: A Comparison of Outcomes, Functional Restoration, and Surgical Considerations.
Acta neurochirurgica. SupplementDistant spread of a supratentorial glioblastoma to the spinal cord.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaPost-treatment changes of tumour perfusion parameters can help to predict survival in patients with high-grade astrocytoma.
European radiologyRegion-Specific Dok2 Overexpression Associates with Poor Prognosis in Human Astrocytoma.
Molecular neurobiologySimultaneous 11C-Methionine Positron Emission Tomography/Magnetic Resonance Imaging of Suspected Primary Brain Tumors.
PloS oneQuantitative Proteomics Reveals Fundamental Regulatory Differences in Oncogenic HRAS and Isocitrate Dehydrogenase (IDH1) Driven Astrocytoma.
Molecular & cellular proteomics : MCPTreatment Outcomes and Prognostic Factors in Adult Astrocytoma: In North East of Iran.
Iranian journal of cancer preventionConcurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model.
OncotargetRelationship Between Cytogenetic Complexity and Peritumoral Edema in High-Grade Astrocytoma.
Annals of laboratory medicineSuccessful Management of Intraoperative Acute Bilateral Pulmonary Embolism in a High Grade Astrocytoma Patient.
The American journal of case reportsIs Upregulation of Aquaporin 4-M1 Isoform Responsible for the Loss of Typical Orthogonal Arrays of Particles in Astrocytomas?
International journal of molecular sciencesHuman herpesvirus multiplex ddPCR detection in brain tissue from low- and high-grade astrocytoma cases and controls.
Infectious agents and cancerIdentification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma.
Scientific reportsA comparison study of (11)C-methionine and (18)F-fluorodeoxyglucose positron emission tomography-computed tomography scans in evaluation of patients with recurrent brain tumors.
Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaA retrospective observational study on the treatment outcomes of 26 patients with spinal cord astrocytoma including two cases of malignant transformation.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research SocietyComparison of cancer survival trends in the United States of adolescents and young adults with those in children and older adults.
CancerHigh-grade glioma in children and adolescents: a single-center experience.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryNitroproteins in Human Astrocytomas Discovered by Gel Electrophoresis and Tandem Mass Spectrometry.
Journal of the American Society for Mass SpectrometryPoly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma.
Molecular cancer therapeuticsMicroRNA-542-3p Suppresses Tumor Cell Invasion via Targeting AKT Pathway in Human Astrocytoma.
The Journal of biological chemistryAnaplastic astrocytoma mimicking herpes simplex encephalitis in 13-year old girl.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology SocietyPrognostic significance of multiple kallikreins in high-grade astrocytoma.
BMC cancerDifferentiation between Solitary Cerebral Metastasis and Astrocytoma on the Basis of Subventricular Zone Involvement on Magnetic Resonance Imaging.
PloS oneRadio-chemotherapy improves survival in IDH-mutant, 1p/19q non-codeleted secondary high-grade astrocytoma patients.
Journal of neuro-oncologyAstrocytic tumour grading: a comparative study of three-dimensional pseudocontinuous arterial spin labelling, dynamic susceptibility contrast-enhanced perfusion-weighted imaging, and diffusion-weighted imaging.
European radiologyStudy of the biodistribution of fluorescein in glioma-infiltrated mouse brain and histopathological correlation of intraoperative findings in high-grade gliomas resected under fluorescein fluorescence guidance.
Journal of neurosurgeryHigh-grade astrocytoma (Glioblastoma Multiforme) in an Atlantic spotted dolphin (Stenella frontalis).
Journal of comparative pathologyThe role of connexin43-Src interaction in astrocytomas: A molecular puzzle.
NeuroscienceAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- TERT Promoter Methylation in Glioblastoma and its Paradoxical Association with Upregulated Gene Expression.
- High-Grade Astrocytoma With Piloid Features: An Aggressive Clinicogenomic Entity Distinct From Pilocytic Astrocytoma.
- Laser interstitial thermal therapy and adjuvant pembrolizumab in recurrent high-grade astrocytoma: a Phase 1/randomized Phase 2b trial.
- Management of glioblastoma intramedullary spinal cord metastasis with advanced intraoperative techniques: a case series and systematic review.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia· 2026· PMID 41734534mais citado
- Pediatric High-Grade Astrocytoma With Piloid Features: A Comprehensive Literature Review.
- The "Azzopardi phenomenon" in high-grade astrocytoma with a PNET-like component.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:251561(Orphanet)
- MONDO:0016680(MONDO)
- GARD:20704(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q55786373(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
