É o tipo mais agressivo de tumor cerebral que se forma a partir dos astrócitos (células de suporte do cérebro), classificado como Grau IV pela Organização Mundial da Saúde (OMS). Ele é formado por células tumorais (astrócitos) muito alteradas, que não se parecem com as células normais. Suas características incluem: células com formas e tamanhos variados, núcleos celulares anormais, muitas células se dividindo rapidamente, formação de coágulos nos vasos sanguíneos, aumento de pequenos vasos sanguíneos e áreas de tecido morto. Geralmente afeta adultos e se localiza principalmente nas maiores partes do cérebro, os hemisférios cerebrais. Ele pode se desenvolver a partir de outros tumores cerebrais menos agressivos, como o astrocitoma difuso Grau II ou o astrocitoma anaplásico. Nesses casos, é chamado de glioblastoma "secundário" e geralmente apresenta uma alteração genética específica (mutação IDH). No entanto, na maioria das vezes, ele aparece de repente, em pouco tempo, sem que houvesse um tumor menos grave antes. Nesses casos, é chamado de glioblastoma "primário" e não apresenta a mutação IDH.
Introdução
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É o tipo mais agressivo de tumor cerebral que se forma a partir dos astrócitos (células de suporte do cérebro), classificado como Grau IV pela Organização Mundial da Saúde (OMS). Ele é formado por células tumorais (astrócitos) muito alteradas, que não se parecem com as células normais. Suas características incluem: células com formas e tamanhos variados, núcleos celulares anormais, muitas células se dividindo rapidamente, formação de coágulos nos vasos sanguíneos, aumento de pequenos vasos sanguíneos e áreas de tecido morto. Geralmente afeta adultos e se localiza principalmente nas maiores partes do cérebro, os hemisférios cerebrais. Ele pode se desenvolver a partir de outros tumores cerebrais menos agressivos, como o astrocitoma difuso Grau II ou o astrocitoma anaplásico. Nesses casos, é chamado de glioblastoma "secundário" e geralmente apresenta uma alteração genética específica (mutação IDH). No entanto, na maioria das vezes, ele aparece de repente, em pouco tempo, sem que houvesse um tumor menos grave antes. Nesses casos, é chamado de glioblastoma "primário" e não apresenta a mutação IDH.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 10 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 15 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
13 genes identificados com associação a esta condição. Padrão de herança: Multigenic/multifactorial, Not applicable.
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated
Nucleus
Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferat
Cell membraneCytoplasmic vesicleEndoplasmic reticulumSecreted
Achondroplasia
A frequent form of short-limb dwarfism. It is characterized by a long, narrow trunk, short extremities, particularly in the proximal (rhizomelic) segments, a large head with frontal bossing, hypoplasia of the midface and a trident configuration of the hands. ACH is an autosomal dominant disease.
Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activati
Cell membraneNucleusCytoplasm, cytosolCytoplasmic vesicle
Pfeiffer syndrome
A syndrome characterized by the association of craniosynostosis, broad and deviated thumbs and big toes, and partial syndactyly of the fingers and toes. Three subtypes are known: mild autosomal dominant form (type 1); cloverleaf skull, elbow ankylosis, early death, sporadic (type 2); craniosynostosis, early demise, sporadic (type 3).
Filament-forming cytoskeletal GTPase (Probable). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity). Plays a role in sperm head formation during spermiogenesis, potentially via facilitating localization of ACTN4 to cell filaments (PubMed:33228246)
CytoplasmCytoplasm, cytoskeletonCell projection, axonCell projection, dendritePerikaryonCytoplasm, perinuclear regionCytoplasmic vesicle, secretory vesicle, acrosome
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed:1493333, PubMed:36651806, PubMed:7479976). On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (PubMed:7479976, PubMed:7628694, PubMed:7796813, PubMed:7878466)
CytoplasmNucleus
Ectodermal dysplasia and immunodeficiency 2
A form of ectoderma dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. This form of ectodermal dysplasia is associated with decreased production of pro-inflammatory cytokines and certain interferons, rendering patients susceptible to infection. EDAID2 inheritance is autosomal dominant.
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (P
CytoplasmCytoplasm, cytoskeleton, microtubule organizing center, centrosomeCytoplasm, cytoskeleton, spindleCytoplasm, cytoskeleton, spindle pole
Ligand-activated transcription factor that forms obligate heterodimers with the retinoic acid receptor and acts as a key regulator of biological processes, such as adipocyte differentiation, lipid metabolism, glucose homeostasis and beta-oxidation of fatty acids (PubMed:16150867, PubMed:20829347, PubMed:23525231, PubMed:8702406, PubMed:8706692, PubMed:9065481). Activated by lipid ligands: binds peroxisome proliferators, such as hypolipidemic drugs, and fatty acids, such as prostaglandin J2 metab
NucleusCytoplasm
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubM
Cell membraneEndoplasmic reticulum membraneGolgi apparatus membraneNucleus membraneEndosomeEndosome membraneNucleusSecreted
Lung cancer
A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues
CytoplasmNucleusCytoplasm, cytoskeleton, microtubule organizing center, centrosomeMidbodyMembrane
Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apop
CytoplasmNucleusNucleus, PML bodyEndoplasmic reticulumMitochondrion matrixCytoplasm, cytoskeleton, microtubule organizing center, centrosome
Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:10521434, PubMed:19935646). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (PubMed:10521434). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity)
Cytoplasm, cytosolPeroxisome
Glioma
Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.
Receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. NELL2 is an endogenous ligand for ROS1. Upon endogenous stimulation by NELL2, ROS1 activates the intracellular signaling pathway and triggers epididymal epithelial differentiation and subsequent sperm maturation (By similarity). May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including
Cell membrane
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) (PubMed:30442762, PubMed:30442766, PubMed:30481304). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes (PubMed:30442762, PubMed:30442766, PubMed:30481304)
Endomembrane systemRecycling endosomeGolgi apparatus
Glioma
Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.
Medicamentos aprovados (FDA)
3 medicamentos encontrados nos registros da FDA americana.
Variantes genéticas (ClinVar)
1,746 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 18 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
121 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Glioblastoma
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Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 39.444
RFC4 drives temozolomide resistance in glioblastoma by activating STK38-BECN1-dependent autophagy.
Este estudo revela que o glioblastoma (GBM) desenvolve resistência à temozolomida (TMZ), sua principal quimioterapia, através da proteína RFC4. A RFC4 ativa um processo de "autofagia" nas células tumorais, tornando-as resistentes ao tratamento ao interagir com a enzima STK38 e a proteína BECN1. A identificação dessa via (RFC4-STK38-BECN1) é crucial, pois oferece uma nova oportunidade para desenvolver terapias mais precisas e superar a resistência em pacientes com GBM.
🇧🇷 traduzidoDeciphering the STAT3-PXN positive feedback loop in GBM, IDH-wildtype: transcriptional regulation and inhibition of YB-1 ubiquitination.
Em Glioblastoma (GBM) IDH-wildtype, um tipo agressivo de câncer cerebral, o estudo identificou que a elevação do gene PXN está associada a um pior prognóstico e maior malignidade. Mecanicamente, PXN forma um ciclo de autoalimentação com STAT3 e estabiliza a proteína YB-1, ambos processos que contribuem para a agressividade da doença. Compreender esses mecanismos oferece novas direções para o desenvolvimento de tratamentos mais eficazes, buscando atingir esses alvos moleculares.
🇧🇷 traduzidoAATF supports proliferation of glioblastoma cells by sustaining mitochondrial respiration through an NRF-1-dependent mechanism.
Este estudo revela que o glioblastoma (GBM), um tumor cerebral agressivo, depende criticamente da respiração mitocondrial para sua proliferação, e a proteína AATF, cuja expressão se correlaciona com o prognóstico do paciente, é essencial para essa dependência. A AATF interage com o NRF-1 para sustentar a transcrição de genes da fosforilação oxidativa (OXPHOS), e sua inibição leva à interrupção do crescimento e à redução da formação de tumores. Para pacientes e médicos, essas descobertas posicionam a AATF como um promissor alvo terapêutico para futuras intervenções, oferecendo uma nova estratégia para combater o avanço do glioblastoma.
🇧🇷 traduzidoHNRNPH1 drives glioblastoma progression by regulating the splicing of cell cycle genes.
Este estudo identificou a proteína HNRNPH1 como um fator crucial para a progressão do Glioblastoma (GBM), sendo super expressa nas células tumorais e essencial para sua divisão e crescimento. Ao silenciar HNRNPH1, observou-se a interrupção do ciclo celular, redução da proliferação e morte das células tumorais, além de inibição do crescimento do tumor e aumento da sobrevida em modelos pré-clínicos. Isso sugere que a HNRNPH1 é um alvo terapêutico promissor, com potencial para o desenvolvimento de novas estratégias de tratamento para pacientes com GBM.
🇧🇷 traduzidoCD47 stabilizes ROBO2 to regulate glioblastoma progression by preventing ITCH-mediated ubiquitination.
Este estudo revela que a proteína CD47, frequentemente elevada nas áreas invasivas do glioblastoma, está associada a pior sobrevida dos pacientes. Ela impulsiona a progressão do tumor (crescimento e disseminação) de forma intrínseca, independentemente da resposta imune, ao estabilizar a proteína ROBO2, que é crucial para a malignidade. Portanto, o bloqueio da via CD47-ROBO2 representa um promissor novo alvo terapêutico para o tratamento do glioblastoma.
🇧🇷 traduzidoPublicações recentes
Lactate-induced lactylation enhances BMAL1 transcription and nuclear translocation, promoting bevacizumab resistance in glioblastoma through VEGFA.
Design, Synthesis and Evaluation of Anticancer Potential of Novel Pyrrolopyrazines Against Glioblastoma: Mechanistic Details and In Vivo Safety Analysis.
EMILIN-1 in the tumor microenvironment: insights from CNS tumors and beyond.
Plasminogen activator inhibitor-1 as an oncologic target: biology, therapeutic inhibitors, and clinical translation.
The autophagy switch: A critical determinant of arsenic-induced carcinogenesis and cancer therapy.
📚 EuropePMC39.004 artigos no totalmostrando 197
Dual Regulation of Post-Translational Modification of Proteins: Bottlenecks and Breakthroughs in NK Cell Therapy for Glioblastoma.
International journal of general medicinePAK4 functions as an immune suppressor by reprogramming the phosphatidylcholine metabolism of CD8 + T cells within the glioblastoma tumor microenvironment.
OncogeneRFC4 drives temozolomide resistance in glioblastoma by activating STK38-BECN1-dependent autophagy.
Nature communicationsDeciphering the STAT3-PXN positive feedback loop in GBM, IDH-wildtype: transcriptional regulation and inhibition of YB-1 ubiquitination.
Cell death discoveryAATF supports proliferation of glioblastoma cells by sustaining mitochondrial respiration through an NRF-1-dependent mechanism.
Cell death & diseaseHNRNPH1 drives glioblastoma progression by regulating the splicing of cell cycle genes.
Cell death & diseasePRDM players in Central Nervous System Cancers: state of the art and future perspectives.
Critical reviews in oncology/hematologyRecent progress and future directions to advance glioblastoma research: A consensus perspective from the 2024 Christopher Davidson Forum.
Neuro-oncologyMolecularly distinct collision tumor consisting of meningothelial meningioma and glioblastoma, IDH-wildtype: illustrative case.
Journal of neurosurgery. Case lessonsCD47 stabilizes ROBO2 to regulate glioblastoma progression by preventing ITCH-mediated ubiquitination.
Proceedings of the National Academy of Sciences of the United States of AmericaExercise-associated microRNA programs as candidate modulators and biomarkers in glioblastoma: a narrative review.
Discover oncologyBiomimetic Nanoplatform for Targeted Glioblastoma Therapy via Concurrently Triggering GPX4/DHODH Mediated Ferroptosis.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Integrative Multi-Omics and Single-Cell Profiling Identify Chitinase Domain Containing Protein 1 (CHID1) as a Prognostic Biomarker in Glioblastoma.
Journal of CancerTemporalis Muscle Thickness as a Prognostic Factor for 30-Day, 90-Day, and Overall Mortality in Newly Diagnosed Glioblastoma.
CureusLessons from Exceptional Responders with High-Grade Brain Tumors Treated with Precision Targeted Therapies.
Journal of immunotherapy and precision oncologyIncreased expression of SMAD5-AS1 in glioma is associated with patient prognosis and immunity.
International journal of clinical and experimental pathologyAptamer-functionalized exosomes combined with doxorubicin suppress GBM progression and enhance chemoradiosensitivity by promoting pyroptosis.
Materials today. BioLongitudinal, label-free, high-resolution imaging of glioblastoma spheroid response to therapy: a translational tool for preclinical evaluation of chemotherapy, radiation, and immunotherapy.
OpticaMEG3 in glioma stem cells promotes glioblastoma angiogenesis through FUBP3-mediated VGF expression.
Clinical and experimental medicinePlant-derived nanocarriers & nanostructures for barrier-defined translation: a comprehensive review of mechanisms, targets, and translation.
Journal of nanobiotechnologyHistogram Analysis of Ultrasound Localization Microscopy for Predicting Isocitrate Dehydrogenase Status in Rat Glioblastoma.
Ultrasound in medicine & biologyAntitumorigenic activity of Rubus sp. fruit extract in C6 rat and U87 human glioma cell lines.
Nutrition (Burbank, Los Angeles County, Calif.)Recent Development of the Probes for Fluorescence Spectroscopy, Mass Spectrometry and Electron Microscopy in Cancer Diagnosis.
Protein and peptide lettersTRIM44 as a Multifunctional Regulator in Cancer and Non-Cancer Diseases: From Oncogenic Driver to Immune and Stress Response Modulator.
Protein and peptide lettersNanotechnology-Based Strategies for Glioblastoma: Diagnostic and Therapeutic Advances.
Current neuropharmacologyGlutamate Drives Glioblastoma Invasion in Three-Dimensional Hyaluronic Acid Hydrogels.
Tissue engineering. Part ADevelopment of Glioblastoma Multiforme in Patients With Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma: A Case Series.
Cancer reports (Hoboken, N.J.)Macrophage membrane-camouflaged nanoparticles for synergistic gene-phototherapy in glioblastoma.
Brain research bulletinConstruction of ammonia death-related lncRNA prognostic signature model and immunomodulatory effect in glioblastoma multiforme.
Brain researchmRNA-based cancer vaccines: A new frontier in personalized immunotherapy.
Biochimica et biophysica acta. Reviews on cancerThe brain imaging feature-related gene NRP2 drives the malignant progression of glioblastoma through the FAK pathway: a Mendelian randomization study.
Translational oncologyFinely-tuned regulator of DNA repair: FBXW7-185aa may modulate glioblastoma radiosensitization and the tumor immune microenvironment.
Translational oncologyUCHL1 promotes temozolomide resistance in glioblastoma by inhibiting the ubiquitination-mediated degradation of keratin 8.
Translational oncologyEZH2 inhibition in resistant glioblastoma stem cells counteracts oxidative stress protection and triggers ferroptosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieTargeting ULK1 and USP20 to modulate autophagy and chemosensitivity in cancer cell lines.
Biomedical reportsCombined Patch-clamp Electrophysiology and Single-Cell Genomic Analysis Reveal Spiking Tumor Cells at the Neocortical Glioblastoma Interface in Humans.
Neuro-oncologyCALLY index provides improved prognostic stratification compared with other inflammation-based scores in glioblastoma treated with the stupp protocol.
BMC cancerReprogramming the immune orchestra for glioblastoma: oncolytic viruses and the B-cell connection.
Cellular & molecular immunologyExploring the dual role of extracellular vesicles in coagulation and immune modulation in glioblastoma.
Scientific reportsETV1 Promotes Glioma Progression via miR-3175/STEAP2 Axis.
BioFactors (Oxford, England)Metabolic Imaging and Molecular Signatures Reveal Metabolic Phenotypes in Recurrent Glioblastoma.
Journal of nuclear medicine : official publication, Society of Nuclear MedicineUnraveling the role of boron microdistribution in BNCT dosimetry of glioblastoma multiforme: combined theoretical and experimental insights.
Physics in medicine and biologyDecoding the biology of the blood-brain tumor barrier in brain cancer.
Molecular cancer research : MCRRAGE Inhibition Reduces Surgery-Induced Cerebral Edema After Glioma Resection.
NeurosurgeryDiscovery, Optimization, and Biological Evaluation of 2-Cyano-2-(9H-xanthen-9-ylidene)acetamide Derivatives as ZNF207 Inhibitors for Anti-Glioma Therapy.
Journal of medicinal chemistryThe TNFR superfamily member Fn14 impacts immunity and survival in experimental gliomas and response to immune checkpoint inhibitor therapy in glioblastoma patients.
Neuro-oncology advancesSurface-engineered dual drug-loaded tumor-targeted liposomal nanoparticles to overcome the therapeutic resistance in glioblastoma multiforme.
Communications medicineNANP targeting radiosensitizes glioblastoma through TNFR1 sialylation-driven mesenchymal shift.
Nature communicationsCelcomen: spatial causal disentanglement for single-cell and tissue perturbation modeling.
Nature communicationsClinical and molecular features of primary gliosarcoma with digital spatial whole-transcriptome analysis of glial and mesenchymal components.
Brain pathology (Zurich, Switzerland)Conditional Survival Estimates for Malignant Glioma Patients: Secondary Analysis of RTOG 9006.
American journal of clinical oncologyIntegrative computational pipeline for the in silico prioritization of potential KIF11-targeting drug candidates in glioblastoma.
Journal of molecular graphics & modellingA genetically optimized physics-informed neural network for multiphysics modeling of magnetic hyperthermia in brain cancer.
Computers in biology and medicineDevelopment and characterisation of a radiobiology proton beamline using radiochromic film dosimetry.
Physics in medicine and biologyImpact of corticosteroid administration on glioblastoma progression before and after adjuvant treatments: recent updates on contradictory findings and mechanistic interactions.
Frontiers in oncologyAntiepileptic drugs in glioblastoma survival: dichotomic or treatment and mechanism of action-dependent variable?
Neuro-oncology advancesDetecting Extrachromosomal DNA from Routine Histopathology.
bioRxiv : the preprint server for biologyIntrinsically disordered SERBP1 regulates translation through topology-driven G-quadruplex recognition.
bioRxiv : the preprint server for biologyAucan targets CDK2 to suppress glioblastoma progression by inhibiting PI3K/AKT pathway-mediated proliferation and inducing apoptosis.
Biochemical pharmacologyGlioma-induced DNMT3A reduction in microglia promotes an anti-tumoral phenotype.
Cell death and differentiationA blueprint for local and distal invasion programs in glioblastoma.
Nature communicationsGlutamate decarboxylase 1 (GAD1) suppresses the progression of glioblastoma through GSK3β/β-catenin pathway.
Cell death discoverySynergistic Effects of Curcumin and Temozolomide in Overcoming Glioblastoma Drug Resistance through Regulation of O6-Methylguanine-DNA Methyltransferase, Mismatch Repair, and Poly(Adenosine Diphosphate Ribose) Polymerase 1.
Drug researchTwo translocation mechanisms drive neural stem cell dissemination into the human fetal cortex.
NeuronMicroglial fructose metabolism is essential for glioblastoma growth.
Proceedings of the National Academy of Sciences of the United States of AmericaSynthetic SIGLEC9-based chimeric switch receptor augments the efficacy of CAR macrophages against glioblastoma.
Proceedings of the National Academy of Sciences of the United States of AmericaPD-L1 Expression in Gliomas: A Potential Immunotherapeutic Target in High-grade Tumours.
Prague medical reportHybrids of harmine and quinoline-based antimalarials show a strong antiproliferative effect on glioblastoma cells and reverse ATP-binding cassette transporter-mediated drug resistance.
Pharmacological reports : PRSurvival and function in elderly patients with GBM: the role of surgical resection with contemporary multimodal therapy.
Journal of neuro-oncologyImmune checkpoint inhibitors in combination with standard treatment versus standard treatment alone for newly diagnosed glioblastoma: a systematic review and meta-analysis.
Neurosurgical reviewSymbiotic exclusivity between CLOCK and TFPI2 drives stemness and immunosuppression in glioblastoma models.
The Journal of clinical investigationPeroxidasin promotes malignant progression by enhancing glycolytic metabolism in glioblastoma through the regulation of LDHA.
Neurological researchGlioMODA: Robust glioma segmentation in clinical routine.
Neuro-oncology advancesConcurrent Ferroptosis and Apoptosis in Resveratrol-Treated Glioblastoma Cells: Relevance With NRF2 Downregulation and Oxidative Stress.
Cell biology internationalRadiomics-based differentiation between glioblastoma and primary central nervous system lymphoma: CT vs MRI.
Cancer imaging : the official publication of the International Cancer Imaging SocietytLyP-1 peptide-modified MnO₂ co-delivering si-SLC16A1 and temozolomide synergistically suppresses glioblastoma via hypoxia modulation and metabolic stress.
Journal of nanobiotechnologyPneumocystis jirovecii pneumonia in a chemotherapy-induced immunocompromised patient with glioblastoma multiforme.
BMJ case reportsImmunotherapy Failure in Glioblastoma: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Critical reviews in oncology/hematologySyntaphilin inhibits glioma invasion via modulating mitochondria redistribution and shapes the immune microenvironment: A potential prognostic biomarker.
GenePreclinical validation of tetrahydroquinoline derivatives as EGFR inhibitor inducing glioblastoma cell death.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical SciencesBacoside-A enhances temozolomide-induced cytotoxicity in U87MG glioblastoma cells via ROS-mediated apoptosis and EGFR/MAPK inhibition.
NeuropharmacologyMulti-omics analysis identifies CCNB1 as a cell cycle factor driving glioblastoma progression and its inhibition by resveratrol.
PloS oneStereotactic Intracranial Implantation of Glioblastoma Patient-derived Xenograft Cell Lines in Mice.
Journal of visualized experiments : JoVEIdentification of new prognostic molecular markers in glioblastoma: a single-center retrospective study.
The oncologistIntegrative multi-omics analysis reveals an 11-gene malignant-myeloid interaction signature and identifies TPST1 as a potential regulator of immunosuppressive microenvironment in glioma.
Discover oncologyMicroRNAs as diagnostic prognostic and therapeutic biomarkers in glioblastoma.
Discover oncologyGPR40 Attenuates Glioma TMZ-Resistance Through Ferroptosis Inhibition.
Neurochemical researchFramework for statistical parametric mapping of the interactions between glioblastoma location, treatment, prognostic variables, and survival using a phase III trial.
Clinical cancer research : an official journal of the American Association for Cancer ResearchThe Size of Glioblastoma Spheroids Influences Patterns of Invasion and Temozolomide Efficacy.
Tissue engineering. Part C, MethodsMismatch repair deficiency reshapes glioblastoma through immune suppression rather than hypermutation.
The Journal of clinical investigationEnhanced Delivery of Aurora Kinase A Inhibitor Alisertib via Tumor-Targeting Immunoliposome Nanocomplex for Improved Treatment of Cancers Including Atypical Teratoid/Rhabdoid Tumor.
International journal of nanomedicineClosing the loop on glioblastoma: A roadmap toward developing bioelectronics for continuous monitoring of tumor state.
APL bioengineeringClinical and genetic determinants of glioblastoma survival: a retrospective study.
Frontiers in molecular neuroscienceAdoptive transfer of ILC2s reveals tumor homing in glioblastoma: a proof-of-concept study.
Frontiers in oncologyVolumetric MRI-based response assessment and prognostic value in newly diagnosed glioblastoma: RANO 2.0 versus mRANO versus RANO.
Neuro-oncology advancesActive immunization strategies in glioblastoma - clinical outcomes and effect modifiers for dendritic vaccines and adoptive cell therapies: a systematic review.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaHarnessing γδ T cells for B7-H3-targeting CAR therapy to enhance anti-tumor therapy in glioblastoma.
Journal of translational medicineM2-like GAMs secreting CSTA drive glioblastoma progression via the ITGB4-TGFB1 feedback axis.
Journal of translational medicineDisrupting Akt-Wnt/β-catenin signaling suppresses glioblastoma stem cell growth and tumor progression in immunocompetent mice.
Journal of neuro-oncologyConstraints, cumulative doses and toxicity outcomes in glioma reirradiation: a systematic review and radiobiological comparison from the Reirradiation Collaborative Group (ReCog).
International journal of radiation oncology, biology, physicsOlfactomedin 1 acts as a tumor suppressor in glioblastoma: integrated analysis and mechanistic prediction.
NeuroscienceFerritin in motion: How systemic iron balance and tumor trafficking shape glioblastoma.
Biochimica et biophysica acta. Reviews on cancerPatterns of failure following stereotactic radiosurgery salvage for recurrent high-grade glioma.
Journal of neuro-oncologyBRAFV600E-mutated central nervous system tumors benefit from treatment with dabrafenib plus trametinib: Results from the Drug Rediscovery Protocol.
European journal of cancer (Oxford, England : 1990)Combining Temozolomide with a Selective CK2 Inhibitor Results in Anti-Tumour Effects in Glioblastoma Cell Lines.
Molecules (Basel, Switzerland)Synthesis and Anticancer Evaluation of PCNA Inhibitor AOH1996 Analogs in Cancer Cell Cultures.
Molecules (Basel, Switzerland)Heat up and Destroy: Immunotherapy of "Cold" Tumors Using the Example of Glioblastoma.
International journal of molecular sciencesTXRF Spectrometry for Investigating CaF2:Nd3+,Y3+ Nanoparticle Diffusion in Tumoral Cancer 3D Spheroids.
International journal of molecular sciencesAP-2 Transcription Factors as Regulators of Ferroptosis: A Family-Wide Profiling in Diverse Cancer Contexts.
International journal of molecular sciencesAdvancements in Drug Delivery Systems in Glioblastoma Therapy.
International journal of molecular sciencesTargeting BRD4-A Promising Therapeutic Option for Glioblastoma?
International journal of molecular sciencesOvercoming Chemoresistance in Glioblastoma: Mechanisms, Therapeutic Strategies, and Functional Precision Medicine.
International journal of molecular sciencesThe Natural Triterpenoid Alisol B Overcomes Temozolomide Resistance in Glioblastoma Through Multi-Target Mechanisms: Coordinated Epigenetic, Metabolic, and Cell-Cycle Reprogramming.
International journal of molecular sciencesDevelopment of microRNA-Based Glioblastoma Biomarkers Using Blood Plasma Specimens.
Diagnostics (Basel, Switzerland)Exosome Engineering for Blocking Gut Dysbiosis and Inducing Cell Death Mechanisms in Glioblastoma Multiforme.
CellsNeuro-Oncological Perspectives on Cancer Stem Cell Biology in Glioblastoma: Implications for Resection, Recurrence, Targeted Therapy, and Other CNS Tumors.
CellsMGMT Promoter and Enhancer Methylation in Melanoma Brain Metastases and Glioblastoma: Shared and Distinct Features.
CellsTranslating Molecular Insights into Effective Targeting of Glioblastoma Stem Cells.
CancersResveratrol and AG490 Overcome Glioblastoma Cells' Resistance to Monotherapy by Inhibiting JAK2/STAT3 Signalling Pathway.
CancersTargeted radio-thermo dual sensitizer magnetic gold core-shells nanoparticles enhance radioresistant glioblastoma via promoting apoptosis and ROS generation.
Cancer cell internationalMyeloid-derived immunosuppression of chimeric antigen receptor T cells in the neuronal microenvironment of glioblastoma.
BMC medicineTumor immunogenicity shapes CNS immune niches and CD8⁺ T cell fate in glioblastoma.
Journal of neuroinflammationExploiting Metabolic Dependencies for Therapeutic Targeting of Brain Cancers.
Cancer lettersEstimating time-dependent cell survival in particle beam thermoradiotherapy with the dynamic temperature-dependent stochastic microdosimetric kinetic model.
Physics in medicine and biologySpeech mapping in awake high-grade glioma resection: subcortical tract proximity as a predictor of language outcomes.
Journal of neurosurgeryEffect of anticancer activity of aripiprazole main metabolite OPC-14857 on malignant glioblastoma.
PloS oneFET PET Does Not Improve Outcomes Compared with MRI for Re-Irradiation of Recurrent Glioblastoma: GLIAA/NOA-10 ARO2013-01 Trial.
Radiology. Imaging cancer[Retracted] Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine‑γ‑lyase function.
Oncology reportsEGFRvIII expression in head and neck squamous cell carcinoma: clinical significance and sources of frequency variation across studies.
Frontiers in oncologyFocused ultrasound for blood-brain barrier opening in brain tumor patients: Technical nuances.
Neuro-oncology advancesVebreltinib for Previously Treated Astrocytoma, IDH-Mutant, Grade 4, and Glioblastoma, IDH Wild-Type with PTPRZ1-MET Fusion Gene: A Multicenter, Phase III Randomized, Open-Label Trial.
Cancer communications (London, England)Assessment of pTERT Subtypes of Glioblastoma by Quantitative FLAIR Analysis Based on Fusing MRI Images.
Brain and behaviorThe lysine methyltransferase KMT5a and p53 regulate the expression of the key autophagy adaptor p62/SQSTM1 in glioblastoma.
Cell communication and signaling : CCSEndogenous immune recruitment in glioblastoma CAR T therapy: cytokine, myeloid, and chemokine circuitry.
Journal of neuro-oncologyMetabolic dependencies and neural progenitor dysregulation: driving forces in paediatric high-grade glioma development.
Cancer metastasis reviewsMatrix stress relaxation promotes glioblastoma cell migration in a ligand-specific manner.
Scientific reportsA lysosomal requiem for glioblastoma cells.
Trends in cancerEligibility assessment for yttrium-90 radioembolisation in patients with recurrent glioblastoma: A single-centre cohort study based on the FRONTIER clinical trial criteria (NCT05303467).
RadiologiaSynthesis and characterization of new P2X7 receptor antagonists as antitumor agents.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieRacial Disparities in Glioblastoma: Can We Untangle Biological From Nonbiological Forces?
JCO oncology practiceUSP7 facilitates brain tumor survival upon glucose deprivation by regulating phosphofructokinase muscle-type nuclear translocation in mice.
PLoS biologyMGMT downregulation by CRISPR/Cas13 RNA-guided RNA targeting enhances glioma cell sensitivity to TMZ chemotherapy.
Journal of neuro-oncologyGlioma-Immune crosstalk in the tumor microenvironment: mechanistic insights and therapeutic translation.
Medical oncology (Northwood, London, England)TERT Promoter Methylation in Glioblastoma and its Paradoxical Association with Upregulated Gene Expression.
Neurology IndiaA novel mucosa-associated lymphoid tissue translocation gene 1-related immune prognostic signature and targeted drug screening for glioblastoma.
Brain circulationDoes coordinated targeting of metabolism and autophagy, modulated by microtubule dynamics, influence therapeutic vulnerability to eribulin in glioblastoma?
Translational cancer research[Xihuang Pills induce mitochondria-associated ferroptosis to enhance therapeutic efficacy of temozolomide against glioblastoma via Nrf2/HO-1/GPX4 signaling axis].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medicaExpanding the Inhibitory Potential of the Benzoxaborinine Scaffold against Carbonic Anhydrases: Synthesis, Structural Characterization, and In Vitro Antitumor Activity.
Journal of medicinal chemistryRapid and sensitive detection of cancer-derived small extracellular vesicles using Janus particles.
Nature biomedical engineeringCorrigendum to "Nose-to-brain delivery of sorafenib-loaded lipid-based poloxamer-carrageenan nanoemulgel: Formulation and therapeutic investigation in glioblastoma-induced orthotopic rat model" [Int. J. Biol. Macromol. 309 (2025) 142861].
International journal of biological macromoleculesThe redox paradox in HGGs: ROS as drivers and destroyers.
Trends in cancerIodinated contrast agents decrease the activity of multidrug resistance protein, cell migration, and induce cell death in different tumor cell lines and glioblastoma spheroids.
Biochimica et biophysica acta. General subjectsA Supportive Group Intervention for Caregivers to Patients Diagnosed With Glioblastoma: Protocol for the SUGRI Study.
JMIR research protocolsCytoskeletal remodeling promotes tunneling nanotube formation and drives cardiac resident cell mitochondrial transfer in sepsis.
Science advancesCC8, a heterodimeric disintegrin from Cerastes cerastes snake venom, triggers apoptosis and restrains the dissemination of human glioblastoma cells.
Pharmacological reports : PRInvestigation of the impact of D, L-methadone on ALA-PDT in multiple glioblastoma cell lines.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for PhotobiologySocioeconomic disparities in IDH-wildtype glioblastoma survival: interactions between age and household income in a SEER cohort.
Journal of neuro-oncologyA Biomimetic Nanoplatform for Near-Infrared-Assisted Heat-Mediated Synergistic Therapy for Glioblastoma.
ACS applied bio materialsThe promise and potential of porphyrin metabolite activation using sonodynamic therapy for the treatment of glioblastoma.
Journal of neuro-oncologyExosomal Lnc-DLK1-35 reprograms microglia into a pro-tumorigenic phenotype via a non-canonical cytokine signature to promote glioblastoma progression and chemoresistance.
Folia histochemica et cytobiologicaRole of human RNase 7 in neuronal and glial cell models: moving towards an unexpected new functional link.
The FEBS journalGliosarcoma: A Reappraisal of Neuroradiological, Surgical, Morphological, and Radiotherapeutic Characteristics of a Cohort From South Italy Single-Center.
Analytical cellular pathology (Amsterdam)Identification of the Antioxidant Enzyme B166 as a Novel Biomarker for Patients With Glioblastoma Multiforme.
Analytical cellular pathology (Amsterdam)Spatial Transcriptomics Meets Histochemistry: Insights from Glioblastoma as a Model System.
Acta histochemica et cytochemicaTargeting MGAT4A-Mediated N-Glycosylation as a Therapeutic Strategy to Inhibit Glioblastoma Stem Cell Invasion.
Exploration (Beijing, China)The Shifting Prognostic Value of Performance Status in Aging Glioblastoma Patients: A Retrospective Cohort Study.
Clinical interventions in agingBrain-targeting nanoplatform repurposing silymarin for enhanced GBM immunotherapy via synergistic mitochondrial suppression.
Materials today. BioRecurrent Glioblastoma and the Tumor Immune Landscape: Emerging Immunotherapeutic Strategies.
ImmunoTargets and therapymiR-181d coordinates homologous recombination and anti-tumor immune responses in glioblastoma.
iScienceEndoscopic Transorbital Approach for Select Recurrent and Newly Diagnosed Anteromedial Temporal Lobe Gliomas.
Journal of neurological surgery. Part B, Skull baseA Brain-Targeting Curcumin Analog Inhibits Glioblastoma Progression Through THBS1/TGF-β1/PI3K-AKT Axis Modulation: Evidence From Experimental and Bioinformatic Analyses.
Journal of cellular and molecular medicineEvolving landscape of glioblastoma research : A 75-year bibliometric study on survival, treatment and gender in authorship.
Wiener klinische WochenschriftPan-cancer analysis of NTRK2 (TRKB) and the anticancer effect of its inhibitor Lucitanib in glioma.
Computational biology and chemistryGlioblastoma survival in rural America: a 10-year experience from a quaternary care center.
Journal of neuro-oncologyFirst-in-Class Small Molecule Inhibitor of Oncogene AVIL in Glioblastoma.
DNA and cell biologyPorous organosilica nanoparticles enable UV blocking and two-photon fluorescence imaging.
Journal of materials chemistry. BRadiomics in glioblastoma recurrence: advances in prediction, localization, and differentiation from treatment-related effects.
Journal of translational medicineDual phagocytosis-checkpoint blockade revitalizes immune surveillance in mouse models of glioblastoma.
Nature communicationsDLD, upregulated by YY1, fuels glioblastoma multiforme progression via EphA2 phosphorylation to activate PI3K/AKT/mTOR.
QJM : monthly journal of the Association of PhysiciansDual role of LY96 in shaping the mesenchymal glioblastoma ecosystem through stem cell maintenance and macrophage MES-like reprogramming.
Cancer lettersAssociation of CDKN2A/B and MTAP deletions in adult-type diffuse gliomas.
Journal of neuropathology and experimental neurologyInvestigation of the impact of resveratrol on sublethal-dose ALA-PDT in glioblastoma cells.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for PhotobiologyFormyl Peptide Receptor-2-Suppressed Autophagy Promotes the Migration and Invasion of Human Glioblastoma Cells Through PI3K/Akt Signaling.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune PharmacologyNeurosurgical leadership in neuro-oncology clinical trials: A nationwide study.
Neurosurgical reviewSurvival and prediction of distant recurrence in glioblastoma.
Neurologia i neurochirurgia polskaProgress in the research and development of oncolytic virus therapies.
Frontiers in pharmacology[64Cu]Cu-Labeled αCD11b Diabody as a Novel PET Tracer for the Detection of Immunosuppression in Glioblastoma.
ACS omegaHigh-grade gliomas and Lynch syndrome: A retrospective descriptive study with a literature review.
Neuro-oncology practiceHealth-related quality of life outcomes of surgery for diffuse glioma: A systematic review and pooled analysis.
Neuro-oncology practiceGliosarcoma of the right cerebellar hemisphere and parahippocampal region: A case report and literature review.
Oncology lettersIGF2BP3-GP130-STAT3-WTAP loop promotes the malignant progression in glioblastoma.
Cellular signallingDENND2D serves as a novel prognostic biomarker with paradoxical protumorigenic effects in glioma.
Discover oncologyComprehensive analysis of the potential role of Ferroptosis-related genes in glioblastoma multiforme.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyElectrochemically optimized multi-component polyacrylonitrile nanofiber scaffolds as a platform for three-dimensional glioblastoma cell culture.
Scientific reportsL1CAM Promotes the Infiltrative Properties of Patient-Derived Glioblastoma Cells.
Cancer scienceA near-infrared fluorescent probe for HClO detection and image-guided surgery in glioblastoma.
Bioorganic chemistryMachine learning model on multi-omics data enables risk stratification and identifies molecular heterogeneity and therapeutic targets in glioblastoma.
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- RFC4 drives temozolomide resistance in glioblastoma by activating STK38-BECN1-dependent autophagy.
- Deciphering the STAT3-PXN positive feedback loop in GBM, IDH-wildtype: transcriptional regulation and inhibition of YB-1 ubiquitination.
- AATF supports proliferation of glioblastoma cells by sustaining mitochondrial respiration through an NRF-1-dependent mechanism.
- HNRNPH1 drives glioblastoma progression by regulating the splicing of cell cycle genes.
- CD47 stabilizes ROBO2 to regulate glioblastoma progression by preventing ITCH-mediated ubiquitination.Proceedings of the National Academy of Sciences of the United States of America· 2026· PMID 41871254mais citado
- Lactate-induced lactylation enhances BMAL1 transcription and nuclear translocation, promoting bevacizumab resistance in glioblastoma through VEGFA.
- Design, Synthesis and Evaluation of Anticancer Potential of Novel Pyrrolopyrazines Against Glioblastoma: Mechanistic Details and In Vivo Safety Analysis.
- EMILIN-1 in the tumor microenvironment: insights from CNS tumors and beyond.
- Plasminogen activator inhibitor-1 as an oncologic target: biology, therapeutic inhibitors, and clinical translation.
- The autophagy switch: A critical determinant of arsenic-induced carcinogenesis and cancer therapy.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:360(Orphanet)
- MONDO:0018177(MONDO)
- GARD:2491(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
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