Uma infecção que pode ser de curta duração (aguda) ou longa duração (crônica), localizada em um só lugar ou espalhada pelo corpo, causada pelo fungo Cryptococcus neoformans. Ela pode afetar os pulmões, o sistema nervoso central e as membranas que o revestem (meninges), a pele e os órgãos internos.
Introdução
O que você precisa saber de cara
Uma infecção que pode ser de curta duração (aguda) ou longa duração (crônica), localizada em um só lugar ou espalhada pelo corpo, causada pelo fungo Cryptococcus neoformans. Ela pode afetar os pulmões, o sistema nervoso central e as membranas que o revestem (meninges), a pele e os órgãos internos.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 17 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 42 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Criptococose
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71 ensaios clínicos encontrados, 2 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 2.622
PDE4B deficiency aids macrophage differentiation and contributes to Cryptococcus neoformans brain infection.
A meningite criptocócica é uma complicação cerebral fatal, e este estudo revela que macrófagos atuam como "cavalos de Tróia", transportando o fungo *Cryptococcus neoformans* para o cérebro. A pesquisa identificou a proteína PDE4B nesses macrófagos como um regulador crucial: sua ativação reduz significativamente a infecção fúngica no cérebro (inclusive após o início da doença), enquanto sua inibição a agrava. Isso aponta a PDE4B como um promissor alvo terapêutico para combater a infecção cerebral.
🇧🇷 traduzidoAn integrative ultrastructural and transcriptomic analysis of host-pathogen interactions with human brain microvascular endothelial cells during cryptococcal infection: a preliminary study.
Este estudo investigou como o fungo *Cryptococcus*, a principal causa de meningite fúngica, interage com as células da barreira hematoencefálica (BBB) para invadir o cérebro. Uma descoberta crucial para pacientes e médicos é que as estirpes ambientais de *Cryptococcus* exibem um potencial invasivo comparável e provocam respostas celulares semelhantes às isoladas de casos clínicos. A pesquisa revelou alterações celulares e genes ativados na virulência do fungo e na resposta do hospedeiro, identificando potenciais alvos moleculares para o desenvolvimento de novas terapias antifúngicas.
🇧🇷 traduzidoInpatient initiation of tuberculosis preventive therapy with 1 month of isoniazid and rifapentine for adults with advanced HIV disease and cryptococcal meningitis (IMPROVE): a non-inferiority, randomised controlled trial.
Para adultos com doença avançada pelo HIV e meningite criptocócica, um estudo randomizado demonstrou que iniciar a terapia preventiva da tuberculose (TPT) com 1 mês de isoniazida e rifapentina ainda durante a internação hospitalar é tão eficaz e seguro quanto iniciá-la ambulatorialmente 6 semanas após o diagnóstico. Esta abordagem de início precoce no hospital foi não-inferior em termos de sobrevida livre de tuberculose e conclusão do tratamento, e até resultou em taxas de adesão superiores. Isso sugere que iniciar o TPT em pacientes internados é uma estratégia viável para melhorar a cobertura em indivíduos de alto risco, após a exclusão de TB ativa.
🇧🇷 traduzidoCryptococcal dumbbell inflammatory pseudotumor mimicking skull histiocytic sarcoma in immunocompetent patient.
Este artigo destaca que a criptococose, uma infecção fúngica geralmente associada a pacientes imunocomprometidos, pode, em casos raros, afetar o crânio de pessoas saudáveis. Nesses casos, a lesão pode imitar radiologicamente tumores malignos agressivos, como o sarcoma, levando a atrasos no diagnóstico. É crucial que médicos incluam infecções fúngicas no diagnóstico diferencial de lesões destrutivas do crânio, independentemente do estado imunológico do paciente, para assegurar um diagnóstico precoce e o tratamento correto.
🇧🇷 traduzidoMicroglia sense fungal infections through capsular components from capillary-bound Cryptococcus neoformans via endothelial nucleotide signaling.
Este artigo revela que, na criptococose, as micróglia (células imunes do cérebro) detectam o fungo *Cryptococcus neoformans* nos capilares antes mesmo de invadir o tecido cerebral, mas, surpreendentemente, essa resposta **promove o crescimento fúngico** em vez de combatê-lo. Entender esse mecanismo – onde componentes fúngicos ativam células endoteliais a liberar sinais que "enganam" as micróglia para ajudar o fungo – oferece novas perspectivas para **desenvolver terapias antifúngicas que modulem a resposta imune do cérebro** e impeçam a progressão da doença.
🇧🇷 traduzidoPublicações recentes
Emerging cryptococcosis cases in Himalayan & sub-Himalayan regions of India.
[Pulmonary cryptococcosis in a non-HIV patient].
Invasive Fungal Infections Following Bruton Tyrosine Kinase Inhibitor Treatment: A Systematic Review and Meta-analysis.
Descriptive epidemiology of opportunistic infections among patients with advanced HIV disease in Kinshasa, Democratic Republic of Congo.
📚 EuropePMC3.309 artigos no totalmostrando 200
Coexistence of pulmonary aspergillosis and cryptococcosis following treatment for SARS-CoV-2 infection in a kidney transplant recipient: a rare case report and literature review.
BMC nephrologyPredictors of mortality among individuals with advanced HIV disease in a contemporary Brazilian cohort.
Revista panamericana de salud publica = Pan American journal of public healthAntifungal activity of emodin against the Cryptococcus neoformans/Cryptococcus gattii complexes: an effect on the enzyme superoxide dismutase.
Canadian journal of microbiologyLimited genome evolution of Cryptococcus neoformans following an accidental infection in the research laboratory.
ASM case reportsPulmonary Cryptococcosis Mimicking Lung Metastasis in a Patient with Pancreatic Cancer: A Case Report and Review of the Literature.
Internal medicine (Tokyo, Japan)Successful Long-Term Use of Isavuconazole in a Tacrolimus-Treated Japanese Kidney Transplant Recipient With Disseminated Cryptococcosis and Probable Invasive Aspergillosis.
CureusDiagnosis of a patient with pulmonary and skeletal cryptococcosis: A case report and literature review.
The Journal of international medical researchCurrent opinion on the potential role of liposomal amphotericin B in underexplored clinical scenarios.
Clinical microbiology reviewsCase Report: Native aortic valve Listeria monocytogenes endocarditis in an adult with Evans syndrome.
Frontiers in immunologyCase Report: The entanglement of infection and autoimmunity: a case of Caplan syndrome.
Frontiers in immunologyPulmonary cryptococcosis beyond human immunodeficiency virus: a five-year cohort study of diagnostic challenges, radiologic mimics, and clinical predictors.
Journal of thoracic diseaseCryptococcus neoformans infection presenting as a mediastinal mass in an immunocompetent child with parrot exposure: a case report and literature review.
Frontiers in medicineLumbar Puncture Frequency and Patient Survival Among Persons Hospitalized with Cryptococcal Meningitis in the United States.
Medical mycologyPDE4B deficiency aids macrophage differentiation and contributes to Cryptococcus neoformans brain infection.
PLoS pathogensEvaluation of the performance of a novel chemiluminescence immunoassay for cryptococcal antigen detection.
Microbiology spectrummGem: Progress on the development of conjugate vaccines for Cryptococcus neoformans infections.
mBioIn vitro effects of IFN-γ, IL-4 and IL-27 on human bronchial epithelial cells infected with Cryptococcus neoformans sensu stricto.
Revista iberoamericana de micologiaMHC-I upregulation and increased glucose dependence define innate antifungal immune responses to Cryptococcus neoformans.
The Journal of infectious diseasesStrain-specific variation in virulence and host-immune modulation across the Cryptococcus gattii species complex.
International journal of medical microbiology : IJMMPulmonary Cryptococcosis Infection in Non-HIV Patients in a Tertiary Care Center in Taiwan.
Pulmonary medicineRoles of Mutation, Ploidy, and Recombination in Adaptive Evolution in Two Divergent Model Yeasts.
GenesPotential therapeutic targets for Cryptococcus.
Medical mycologyAn integrative ultrastructural and transcriptomic analysis of host-pathogen interactions with human brain microvascular endothelial cells during cryptococcal infection: a preliminary study.
Frontiers in cellular and infection microbiology[A case of pulmonary cryptococcosis in dust-exposed worker].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseasesPretransplant serologic testing for fungal infections in a large commercial health insurance database, United States.
Medical mycologyCryptococcus neoformans responds to presence of Mycobacterium by diversifying its morphologies and remodelling its capsular material.
Journal of medical microbiologyMetabolic plasticity and virulence of Cryptococcus neoformans are regulated by mitochondrial homeostasis.
bioRxiv : the preprint server for biologyPresentation and prognosis of cryptococcosis requiring intensive care unit admission in France: the CRYPTO-ICU study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaAn uncommon cancer mimic diagnosed via endobronchial ultrasound.
Breathe (Sheffield, England)The cyclin dependent kinase (CDK)7 inhibitor BS-181 inhibits pathogenic Cryptococcus species, causing G2/M arrest and a splicing defect.
VirulenceBrain structural and MRI phenotypes in intracranial cryptococcosis: a comparative study based on HIV status.
BMC infectious diseases18F-FDG PET/CT in Disseminated Cryptococcosis Mimicking Malignancy With Rib Osteolysis and Chest Wall Invasion.
Clinical nuclear medicineInhibition of the α7 nicotinic acetylcholine receptor alleviates pyroptosis in blood-brain barrier induced by Cryptococcusneoformans.
Microbial pathogenesisAntifungal repurposing of clinical chelator DMSA against Cryptococcus neoformans via laccase and histidine biosynthesis inhibition.
Microbial pathogenesisHeadache as a Predictor of Cryptococcal Meningitis in Ambulatory Patients With Symptomatic HIV-associated Cryptococcal Antigenemia.
Open forum infectious diseasesPhosphatidylcholine biosynthesis pathways in Cryptococcus neoformans: functional interplay and impact on virulence.
Frontiers in cellular and infection microbiologyLatent Tuberculosis Infection and Cryptococcus and Rhinovirus Co-Infection in an Immunosuppressed Patient.
Clinical laboratoryIntralobar pulmonary sequestration coexisting with pulmonary cryptococcosis: A case report and literature review.
Experimental and therapeutic medicineInpatient initiation of tuberculosis preventive therapy with 1 month of isoniazid and rifapentine for adults with advanced HIV disease and cryptococcal meningitis (IMPROVE): a non-inferiority, randomised controlled trial.
The lancet. HIVOne-pot recombinase polymerase amplification and CRISPR/Cas12a assay for Cryptococcus neoformans.
Applied microbiology and biotechnologyCryptococcal dumbbell inflammatory pseudotumor mimicking skull histiocytic sarcoma in immunocompetent patient.
Surgical neurology internationalMicroglia sense fungal infections through capsular components from capillary-bound Cryptococcus neoformans via endothelial nucleotide signaling.
PLoS biologyPrp8 Intein-Targeted Fluorescent Probe for Specific Detection of Cryptococcus neoformans and Inhibitor Screening.
Analytical chemistryChallenges in diagnosing cryptococcosis among HIV-infected patients in southern Mozambique and opportunities for intervention in contexts of limited resources: A pre-implementation study.
PloS oneClinical and diagnostic misperception of tuberculosis and systemic fungal infections.
Journal de mycologie medicaleTwo cases of refractory Cryptococcus gatti (C gatti) infection and literature review: Case report.
Medicine[Disseminated cryptococcosis resulting in fungal septic shock: a case report].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseasesOrgan-specific immune responses are strain-dependent in a mouse model of Cryptococcus neoformans brain infection.
Microbiology spectrumDevelopment Framework of Desirability of Outcome Ranking Endpoints for Use in Clinical Trials of Invasive Fungal Diseases.
Open forum infectious diseasesDiagnostic value of combined detection of cryptococcal antigen in serum and lung puncture fluid using lateral flow assay for diagnosing pulmonary cryptococcosis: a single-center prospective study.
Frontiers in microbiologyRethinking Routine Lumbar Puncture and Induction Therapy in Non-HIV Pulmonary Cryptococcosis: A Call for Risk-Based Management.
MycopathologiaIntegrative Transcriptomic and Systems Biology Analyses Identify TCB1 as a Calcium-Responsive Gene in Cryptococcus neoformans.
MicroorganismsCryptococcosis in Colombia: Analysis of Data from Laboratory-Based Surveillance 2017-2024.
Journal of fungi (Basel, Switzerland)Adrenal Insufficiency due to Disseminated Cryptococcus in an Immunocompetent Individual.
Case reports in endocrinologyRare Cutaneous Presentation of Disseminated Cryptococcus gattii Infection in an Immunocompetent Male: A Case Report.
CureusAcetylation-mediated fluconazole inactivation: A novel antifungal resistance mechanism.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapyLongitudinally Extensive Transverse Myelitis and Vasculitis by Cryptococcosis in a Non-HIV Patient: A Case Report.
Case reports in neurologyHost-membrane lipid composition controls Cryptococcus neoformans cellular targets.
Frontiers in immunologySerum cryptococcal antigen gradient detection for monitoring the efficacy and medical guidance of the treatment of pulmonary cryptococcosis: a case report.
BMC infectious diseasesParasitic and fungal central nervous system infections in hospitalised adults living with HIV in Libreville, Gabon: clinical profiles to inform syndromic triage in resource limited settings.
AIDS research and therapyPulmonary Fungal Infections in the Immunocompetent Host.
ChestProbable disseminated cryptococcosis relapse in a patient with Hodgkin's lymphoma treated with induction therapy resumption and autologous stem cell transplant.
Journal de mycologie medicaleTemperature and genetic background drive mobilization of diverse transposable elements in a global human fungal pathogen.
PLoS geneticsConjugation of a Cryptococcus neoformans-derived metalloprotease to antifungal-loaded PLGA nanoparticles treats neural cryptococcosis in an in vitro model.
PloS oneResearch priorities for advanced HIV disease in Latin America and the Caribbean region: a modified Delphi study.
Journal of the International AIDS SocietyPulmonary Cryptococcosis in an Immunocompetent Patient: Negative mNGS but Positive Antigen Test.
Clinical laboratoryWhen an Adrenal Mass Isn't Cancer: A Rare Case of Mycobacterium genavense Mimicking a Neuroendocrine Tumor.
JCEM case reportsCryptococcal antigen titers and semi-quantitative assay scores among people with HIV-associated cryptococcal antigenemia.
Journal of clinical microbiologyConstrictive Pericarditis Due to Cryptococcus Neoformans in an Elderly Immunosuppressed Patient.
European journal of case reports in internal medicineCryptococcus neoformans causing localised osteomyelitis of the right anterior rib.
BMJ case reportsOccult cryptococcal meningitis presenting as myelopathy from an arachnoid cyst.
BMJ case reportsFatal Outcome due to Disseminated Cryptococcosis in a Patient With HIVrequiring Veno-Arterial Extracorporeal Membrane Oxygenation: A Case Report.
Acute medicine & surgerySuccessful desensitization to liposomal amphotericin B for the treatment of disseminated cryptococcosis in pregnancy: a case report.
ASM case reportsClinical spectrum, immune status, and prognostic factors of cryptococcosis: insights from a large, multi-center, ambispective cohort study in southeastern China.
Infectious diseases of povertyCsDETC: detection and counting of small target Cryptococcus spp.
Frontiers in cellular and infection microbiologyClinicopathological Features, Treatment Outcome, and the Cryptococcal Antigen Latex Agglutination System Titer in Feline Cryptococcosis Treated with Amphotericin B and Fluconazole.
Veterinary sciencesPoint-of-Need Test of Cryptococcus Utilizing Aggregation-induced Emission-based Lateral Flow Immunoassay.
Analytical chemistryPrevalence of Cryptococcal Antigenemia Among Human Immunodeficiency Virus Infection or Acquired Immunodeficiency Syndrome Patients Attending the Retroviral Clinic in University of Maiduguri Teaching Hospital.
Nigerian journal of clinical practiceA conserved enzymatic toolkit targeting host cell metabolism is associated with Cryptococcus neoformans intracellular survival in protozoal and mammalian phagocytic cells.
PLoS pathogensVaccine-Mediated Protection of Mice Against African and Asian Clinical Strains of Cryptococcus neoformans.
Journal of fungi (Basel, Switzerland)An Emerging Infectious Yeast to Watch: Cryptococcus gattii Species Complex.
Journal of fungi (Basel, Switzerland)Unusual Neuropsychiatric Presentation of Cryptococcus neoformans Meningoencephalitis in an Immunosuppressed Patient with Rheumatoid Arthritis: A Case Report.
Diseases (Basel, Switzerland)Cryptococcid Sweet Syndrome in the Setting of Hydralazine-Induced ANCA Vasculitis: A Case Report.
Journal of cutaneous pathologyPrimary Cutaneous Cryptococcosis Mimicking Vasculitis in a Patient with Rheumatoid Arthritis.
The new microbiologica[Indole-3-acetic acid alleviates Cryptococcus neoformans-induced pyroptosis in cerebral microvascular endothelial cells by regulating stress granule-mediated NLRP3 inflammasome activation].
Nan fang yi ke da xue xue bao = Journal of Southern Medical UniversityDevelopment of a Multiplex qPCR to Detect and Identify Cryptococcus neoformans and Cryptococcus gattii.
ACS omegaCryptococcal immune reconstitution inflammatory syndrome: Cutaneous clues to disseminated cryptococcosis in a human immunodeficiency virus patient coinfected with tuberculosis on antiretroviral therapy.
Indian journal of sexually transmitted diseases and AIDSCryptococcal Infection in a Patient With Chronic Lymphocytic Leukaemia Receiving Acalabrutinib, a Bruton's Tyrosine Kinase Inhibitor: A Case Report.
CureusMultifocal Intracranial Cryptococcoma with Treatment Resistance, Recurrence, and Mortality: A Case Report and Literature Review.
NMC case report journalThe catalase gene CAT2 and its role in the virulence of one sub-cluster of Cryptococcus gattii VGI clinical isolates.
Acta biochimica et biophysica SinicaIn vitro and in vivo efficacy of the antimycobacterial molecule SQ109 against the human pathogenic fungus, Cryptococcus neoformans.
PLoS neglected tropical diseasesDormant yet dangerous: the role of cell rest in perseverance.
Future microbiologyBilateral Multifocal Cutaneous Panniculitis in a Kidney Transplant Patient With a History of Successfully Treated Cryptococcal Meningitis: A New Clinical Presentation of Localized Subcutaneous Cryptococcosis.
Transplant infectious disease : an official journal of the Transplantation SocietyCytometric Analysis of CD3 + CD4 + T Populations and Activation and Regulation Status of Naïve and Memory CD4 + CD45RA T Cells in Immunocompetent Patients with Neurocryptococcosis.
MycopathologiaIntracellular C. neoformans infection stimulates increased glycolytic activity in fetal liver-derived alveolar-like macrophages.
bioRxiv : the preprint server for biologyEvaluation of routine screening for early detection of Histoplasma and Cryptococcus antigens in CD4-referred blood specimens in Colombia: A prospective study of prevalence and geographic distribution.
Medical mycologyPulmonary cryptococcosis coexisting with lung cancer: a Chinese multicenter retrospective study.
Quantitative imaging in medicine and surgeryMp1p antigen as a sensitive diagnostic marker for early detection and treatment monitoring of Talaromyces Marneffei infection.
BMC immunology[Clinical practice guidelines for the diagnosis and management of invasive pulmonary fungal diseases (2025 Edition)].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseasesReactive oxygen species drive the aberrant immune response to a C. neoformans chitin synthase 3 (chs3Δ) mutant.
Frontiers in immunologyIn toto imaging shows intravascular proliferation promotes transmigration of daughter cells during brain invasion of Cryptococcus neoformans.
Cell reportsEvaluation of a lateral flow immunochromatographic assay for detecting cryptococcal antigens in bronchoalveolar lavage fluid from HIV-negative patients with pulmonary cryptococcosis.
Microbiology spectrumHybrid genome sequence of Cryptococcus neoformans of Indian origin and comparative genome analysis.
Scientific reportsLaryngeal cryptococcosis.
The American journal of medicine[The Chinese guidelines for the diagnosis and treatment of invasive fungal disease in patients with hematological disorders and cancers (the seventh revision)].
Zhonghua nei ke za zhiExploring therapeutic targets for cryptococcosis: in silico and in vitro testing for isocitrate lyase (ICL1) potential inhibitors.
Journal of computer-aided molecular designCryptococcus exploits delayed microglial activation, and microglial osteopontin/Spp1 impairs peripheral host control.
Cell host & microbeCryptococcosis in kidney transplant recipients: Pathogenesis, clinical challenges, and evolving therapeutic strategies.
Transplantation reviews (Orlando, Fla.)From neglected to notable: A growing public health challenge driven by hospitalization for sporotrichosis in Pernambuco, Northeast Brazil (2016-2024).
PLoS neglected tropical diseasesMannoprotein Cig1 contributes to the immunogenicity of a heat-killed F-box protein Fbp1 Cryptococcus neoformans vaccine model.
Infection and immunity[Central nervous system vasculitis in immunocompetent patients with cryptococcal meningitis].
MedicinaIsolation of Cryptococcus gattii (genotype VGI) from a specimen of Pinus. An approach to its natural habitat in México City.
Revista iberoamericana de micologiaThe very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase Phs1 regulates ATP levels and virulence in Cryptococcus neoformans.
BMC microbiologySecond generation repurposing of phenothiazine antipsychotic drugs as antifungal lead molecules via optimization of phenoxazine derivatives.
European journal of medicinal chemistryWeb-Based Dashboard for Tracking Cryptococcosis-Related Deaths in Brazil (2000-2022).
Tropical medicine and infectious diseaseColonization of the central nervous system as a key factor in the Cryptococcus gattii pathogenicity.
VirulenceCapsular polysaccharides from Cryptococcus neoformans suppress cancer through apoptosis and immune cell activation.
International immunopharmacologyCentral nervous system cryptococcosis with brain stem hemorrhage during chemotherapy for pediatric acute myeloblastic leukemia patient.
Journal of infection and chemotherapy : official journal of the Japan Society of ChemotherapyPolystyrene nanoparticles reduce the Cryptococcus neoformans virulence via induction of mitochondrial dysfunction.
Frontiers in cellular and infection microbiologyIsolation of Naganishia diffluens (formerly Cryptococcus diffluens) from skin lesions of a patient with leukemia.
Revista iberoamericana de micologiaCase Report: A Pulmonary Cryptococcosis Presenting as Interstitial Pneumonia in a Patient of IgA Nephropathy.
Infection and drug resistanceOral L-Arginine treatment attenuates Cryptococcus neoformans extrapulmonary dissemination and disease progression.
VirulenceChallenges in the management of intracranial hypertension in pediatric patients with HIV: a case report.
Frontiers in medicineEffectiveness of voriconazole therapy for pulmonary cryptococcosis in fluconazole treatment failure: a multicenter real-world study.
BMC infectious diseasesBalloon dilatation for bronchoscope delivery: first-in-human trial of a novel technique for peripheral lung field access.
ThoraxRapid respiratory cryptococcosis detection using targeted next-generation sequencing.
PLoS neglected tropical diseasesCryptococcosis in patients with myasthenia gravis: clinical characteristics and management strategy.
Frontiers in cellular and infection microbiologyA fatal case of chronic Cryptococcus neoformans meningitis progressing over a 4-year period following cladribine therapy.
ASM case reportsImpact of Cryptococcosis on the Immune Recovery of Patients with AIDS and Severe Immunosuppression.
MycopathologiaDisseminated cryptococcosis involving the adrenal gland and brain in an immunocompetent patient: A case report.
MedicineDisseminated Cryptococcosis: A Diagnostic Challenge in an Immunocompromised Patient.
European journal of case reports in internal medicinePrevalence and risk factors of adverse drug events with dolutegravir-based regimens among Thai people living with HIV: a retrospective cohort study.
AIDS research and therapyMetagenomic next-generation sequencing facilitates precision treatment and prognostic improvement in pulmonary cryptococcosis.
Frontiers in cellular and infection microbiologyEyelid Ptosis as an Atypical Manifestation of Meningeal Cryptococcosis: A Case Report.
CureusUnusual cutaneous manifestations of disseminated Cryptococcus gattii infection in an immunocompetent host.
Revista do Instituto de Medicina Tropical de Sao PauloInvasive fungal infections in the Nigerian paediatric population: A systematic review.
Journal de mycologie medicaleTarget product profile and discovery and development path for novel cryptococcal disease treatments.
The Journal of infectionCryptococcus neoformans phospholipase B1 is critical for cryptococcoma formation in the mouse brain.
Frontiers in immunologyAn 80-year-old man with a rare disease manifestation of disseminated cryptococcosis.
IDCasesThe Capsular Polysaccharides GXM and GXMGal from Cryptococcus neoformans Modulate Macrophages Infected with Leishmania major.
MicroorganismsProgression of Pulmonary Cryptococcosis Refractory to Antifungal Therapy.
American journal of respiratory and critical care medicineOptimizing antifungal dosing for invasive Cryptococcus infections: minimum inhibitory concentration distributions and pharmacokinetic/pharmacodynamic insights from 2010-2023 Antimicrobial Testing Leadership and Surveillance data.
Frontiers in pharmacologyUnexpected variability in laboratory and clinical assays used to quantify Cryptococcus neoformans polysaccharide.
The Journal of infectious diseasesCryptococcus displays spore-specific uptake by alveolar epithelial cells.
mBioInvoluntary Movement Disorders in Central Nervous System Fungal Infections: A Systematic Review.
Movement disorders clinical practiceDisseminated cryptococcosis in an HIV patient with hepatitis C as the associated risk factor.
Current medical mycologyReconsidering the blood-brain barrier: histopathology and microanatomy of cryptococcal CNS infection.
Microbiology and molecular biology reviews : MMBRCanine meningitis and meningoencephalitis in eastern Australia.
Australian veterinary journalMolecular epidemiology and antifungal susceptibilities of Cryptococcus neoformans in bird droppings from zoological gardens and public places in Peninsular Malaysia.
Tropical biomedicineCryptococcal Meningitis Without Headache: A Case Report Highlighting an Atypical Presentation.
CureusMajor revision version 13.0 of the European AIDS Clinical Society guidelines 2025.
HIV medicineEstimated burden of serious mycoses in Poland.
Scientific reportsDisseminated cryptococcosis presenting as lung mass.
BMJ case reportsUnisexual reproduction in the global human fungal pathogen Cryptococcus neoformans.
Proceedings of the National Academy of Sciences of the United States of AmericaWhole Blood Proteome Dynamics Defines Predictive Diagnostic and Prognostic Signatures of Cryptococcal Infection.
Molecular & cellular proteomics : MCPDiagnostic performance of lateral flow antigen tests versus latex agglutination for cryptococcosis in dogs and cats.
American journal of veterinary researchPredictive value of C-reactive protein for hospitalization and mortality among people with advanced HIV disease in Uganda receiving the WHO-recommended package of care.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaPostpartum pulmonary cryptococcosis combined with pulmonary embolism: a case report.
BMC pulmonary medicineCorrigendum to "Lung-resident memory Th2 cells regulate pulmonary cryptococcosis by inducing type-II granuloma formation" [Mucosal Immunol. 18(3) (2025) 631-642].
Mucosal immunologyTranscriptomic profiling of lung alveolar macrophages reveals distinct contribution of sterol metabolism in macrophage response to Cryptococcus gattii infection.
PloS oneEffects of simulated microgravity on biological features and virulence of the fungal pathogen Cryptococcus neoformans.
Applied and environmental microbiologyCan liposomal amphotericin B be used as a preventive measure for cryptococcal meningitis?
Expert review of anti-infective therapyPrimary Orbital Cryptococcosis in an Immunocompetent Child: A Case Report.
Ophthalmic plastic and reconstructive surgeryCryptococcus neoformans serotype A virulence and pathogenicity are capsular glucuronoxylomannan (GXM) motif composition dependent.
mBioCryptococcal infection: host immunity, immune evasion and emerging immunotherapeutic strategies.
Frontiers in cellular and infection microbiologyEvaluating the diagnostic efficacy of metagenomic next-generation sequencing in bronchoalveolar lavage fluid for pulmonary cryptococcosis with different clinical and imaging characteristics.
BMC infectious diseasesCryptococcus neoformans tibial osteomyelitis in an immunocompetent host: a case diagnosed by tNGS.
BMC infectious diseasesReport of a feline Cryptococcus neoformans infection in Hungary.
Acta veterinaria HungaricaWhat Do We Know About Cryptococcus spp. in Portugal? One Health Systematic Review in a Comprehensive 13-Year Retrospective Study (2013-2025).
Journal of fungi (Basel, Switzerland)Non-Tuberculous Laryngeal Granulomas: Systematic Review and Case Series.
ANZ journal of surgeryCryptococcus gattii Infection in the Carpal Joint of a Goat.
Veterinary clinical pathologyAdvancing antifungal therapy: exploring targeted CFW-PEc-enhanced ethosomal formulations of amphotericin B against cryptococcal pneumonia.
Microbiology spectrumGlobal proteomic analysis of Cryptococcus neoformans clinical strains reveals significant differences between latent and lethal infection.
mSystemsThe Pain Is in the Brain With the Sugar-Coated Killer.
The Journal of infectious diseasesInduction of pan-azole resistance in Cryptococcus neoformans by agrochemical azole uniconazole through upregulation of efflux and chromosomal disomies.
Frontiers in cellular and infection microbiologyAdrenal Corticosteroids and Increased Intracranial Pressure in Nonimmunocompromised Patients With Cryptococcal Meningitis.
The Journal of infectious diseasesImmunomodulatory effects of Cryptococcus neoformans capsular polysaccharides on macrophage infected with Trypanosoma cruzi.
Acta tropicaInsights from Mass Spectrometry-Based Proteomics on Cryptococcus neoformans.
Journal of fungi (Basel, Switzerland)Shifting epidemiology and microbiological profiles of cryptococcosis in a Brazilian tertiary center: A descriptive study of 94 patients.
Revista iberoamericana de micologiapCramoll therapy decreases mortality and fungal burden in immunosuppressed mice infected with Cryptococcusgattii.
Microbial pathogenesisDisseminated Cryptococcosis With Multifocal Osteomyelitis Presenting as a Non-Healing Ulcer in a Kidney Transplant Recipient.
Transplant infectious disease : an official journal of the Transplantation SocietyEvaluation of the semi-quantitative BIOSynex® CryptoPS test in serum and cerebrospinal fluid samples of patients with cryptococcosis diagnosed through the IMMY CrAg® lateral flow assay: a translational study.
Diagnostic microbiology and infectious diseaseDeubiquitinase Ubp5 is essential for pulmonary immune evasion and hematogenous dissemination of Cryptococcus neoformans.
MycologyA novel arylnaphthalene lignan analogue targets CYP51 to inhibit Cryptococcus neoformans growth.
Bioorganic chemistryAcute Toxicity and Genotoxicity of cMoL, a Lectin From Moringa oleifera Seeds With Antifungal Activity Against Cryptococcus Strains.
Journal of applied toxicology : JATEffects of novel organoantimony compounds on the fungal pathogen Cryptococcus neoformans.
Journal of medical microbiologyNaganishia albidus Causing Perioral Cutaneous Infection: A Rare Case Easily Misdiagnosed.
Infection and drug resistanceAddison's disease due to adrenal insufficiency in an immunocompetent patient with disseminated cryptococcosis. Case report.
Revista peruana de medicina experimental y salud publicaGenomic Evidence for a-α Heterothallic and α-α Unisexual Mating and Recombination in an Environmental Cryptococcus deneoformans Population.
bioRxiv : the preprint server for biologyMediastinal cryptococcoma as part of disseminated cryptococcosis in HIV-negative pregnant woman with Myasthenia Gravis: Autopsy case report.
Medical mycology case reportsRare Case of Systemic Cryptococcal Lymphadenopathy in a Persian Cat.
Veterinary medicine and scienceUbiquitin degradation of the Ribonuclease H2 subunit B Rnh2B regulates the virulence of Cryptococcus neoformans.
VirulenceBone marrow cryptococcosis in an HIV-infected patient: A case report and literature review.
Journal de mycologie medicaleCgm1 is a β-galactoside α-(1 → 4)-mannosyltransferase involved in the biosynthesis of capsular glucuronoxylomannogalactan in Cryptococcus neoformans.
The Journal of biological chemistryA method for authenticating the fidelity of Cryptococcus neoformans knockout collections.
Microbiology spectrumA case of humidifier lung potentially caused by Cryptococcuslaurentii.
Respiratory investigationThe outcomes of cryptococcal disease in HIV-positive individuals following COVID-19 infection: A systematic review and meta-analysis.
Journal of infection and public healthThe Role of Nutritional Environment in Cryptococcus gattii Titan Cells' Ultrastructure, Biophysical Properties, Molecular Features, and Virulence in Cryptococcosis.
Infectious disease reportsDevelopment of a multiplex-PCR assay for differentiation of Cryptococcus species using the PRP8 gene region.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]Puf4 -mediated oxidative stress virulence attenuation in Cryptococcus neoformans.
Frontiers in cellular and infection microbiologyAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- PDE4B deficiency aids macrophage differentiation and contributes to Cryptococcus neoformans brain infection.
- An integrative ultrastructural and transcriptomic analysis of host-pathogen interactions with human brain microvascular endothelial cells during cryptococcal infection: a preliminary study.
- Inpatient initiation of tuberculosis preventive therapy with 1 month of isoniazid and rifapentine for adults with advanced HIV disease and cryptococcal meningitis (IMPROVE): a non-inferiority, randomised controlled trial.
- Cryptococcal dumbbell inflammatory pseudotumor mimicking skull histiocytic sarcoma in immunocompetent patient.
- Microglia sense fungal infections through capsular components from capillary-bound Cryptococcus neoformans via endothelial nucleotide signaling.
- Editorial: Targeting major human fungal pathogens: novel insights into virulence and antifungal therapies.
- Emerging cryptococcosis cases in Himalayan & sub-Himalayan regions of India.
- [Pulmonary cryptococcosis in a non-HIV patient].
- Invasive Fungal Infections Following Bruton Tyrosine Kinase Inhibitor Treatment: A Systematic Review and Meta-analysis.
- Descriptive epidemiology of opportunistic infections among patients with advanced HIV disease in Kinshasa, Democratic Republic of Congo.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:1546(Orphanet)
- MONDO:0005724(MONDO)
- GARD:6218(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q1470140(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
