Raras
Buscar doenças, sintomas, genes...
Criptococose
ORPHA:1546CID-10 · B45.1CID-11 · 1F27DOENÇA RARA

Uma infecção que pode ser de curta duração (aguda) ou longa duração (crônica), localizada em um só lugar ou espalhada pelo corpo, causada pelo fungo Cryptococcus neoformans. Ela pode afetar os pulmões, o sistema nervoso central e as membranas que o revestem (meninges), a pele e os órgãos internos.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

Uma infecção que pode ser de curta duração (aguda) ou longa duração (crônica), localizada em um só lugar ou espalhada pelo corpo, causada pelo fungo Cryptococcus neoformans. Ela pode afetar os pulmões, o sistema nervoso central e as membranas que o revestem (meninges), a pele e os órgãos internos.

Pesquisas ativas
2 ensaios
71 total registrados no ClinicalTrials.gov
Publicações científicas
6.923 artigos
Último publicado: 2026

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: B45.1
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🧠
Neurológico
6 sintomas
🫁
Pulmão
5 sintomas
👁️
Olhos
4 sintomas
🩸
Sangue
2 sintomas
🛡️
Imunológico
2 sintomas
🦴
Ossos e articulações
2 sintomas

+ 17 sintomas em outras categorias

Características mais comuns

55%prev.
Febre
Frequente (79-30%)
55%prev.
Imunodeficiência
Frequente (79-30%)
55%prev.
Padrão nodular na TCAR pulmonar
Frequente (79-30%)
55%prev.
Tosse
Frequente (79-30%)
17%prev.
Linfadenopatia mediastinal
Ocasional (29-5%)
17%prev.
Dispneia
Ocasional (29-5%)
42sintomas
Frequente (4)
Ocasional (22)
Muito raro (16)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 42 características clínicas mais associadas, ordenadas por frequência.

FebreFever
Frequente (79-30%)55%
ImunodeficiênciaImmunodeficiency
Frequente (79-30%)55%
Padrão nodular na TCAR pulmonarNodular pattern on pulmonary HRCT
Frequente (79-30%)55%
TosseCough
Frequente (79-30%)55%
Linfadenopatia mediastinalMediastinal lymphadenopathy
Ocasional (29-5%)17%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico6.923PubMed
Últimos 10 anos200publicações
Pico2025115 papers
Linha do tempo
2026Hoje · 2026🧪 1993Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
Aprovado2
3Fase 32
·Pré-clínico9
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 13 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Criptococose

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

2 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

71 ensaios clínicos encontrados, 2 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
2.622 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 2.622

#1

PDE4B deficiency aids macrophage differentiation and contributes to Cryptococcus neoformans brain infection.

PLoS pathogens2026 Mar

A meningite criptocócica é uma complicação cerebral fatal, e este estudo revela que macrófagos atuam como "cavalos de Tróia", transportando o fungo *Cryptococcus neoformans* para o cérebro. A pesquisa identificou a proteína PDE4B nesses macrófagos como um regulador crucial: sua ativação reduz significativamente a infecção fúngica no cérebro (inclusive após o início da doença), enquanto sua inibição a agrava. Isso aponta a PDE4B como um promissor alvo terapêutico para combater a infecção cerebral.

🇧🇷 traduzido
#2

An integrative ultrastructural and transcriptomic analysis of host-pathogen interactions with human brain microvascular endothelial cells during cryptococcal infection: a preliminary study.

Frontiers in cellular and infection microbiology2026

Este estudo investigou como o fungo *Cryptococcus*, a principal causa de meningite fúngica, interage com as células da barreira hematoencefálica (BBB) para invadir o cérebro. Uma descoberta crucial para pacientes e médicos é que as estirpes ambientais de *Cryptococcus* exibem um potencial invasivo comparável e provocam respostas celulares semelhantes às isoladas de casos clínicos. A pesquisa revelou alterações celulares e genes ativados na virulência do fungo e na resposta do hospedeiro, identificando potenciais alvos moleculares para o desenvolvimento de novas terapias antifúngicas.

🇧🇷 traduzido
#3

Inpatient initiation of tuberculosis preventive therapy with 1 month of isoniazid and rifapentine for adults with advanced HIV disease and cryptococcal meningitis (IMPROVE): a non-inferiority, randomised controlled trial.

The lancet. HIV2026 Mar

Para adultos com doença avançada pelo HIV e meningite criptocócica, um estudo randomizado demonstrou que iniciar a terapia preventiva da tuberculose (TPT) com 1 mês de isoniazida e rifapentina ainda durante a internação hospitalar é tão eficaz e seguro quanto iniciá-la ambulatorialmente 6 semanas após o diagnóstico. Esta abordagem de início precoce no hospital foi não-inferior em termos de sobrevida livre de tuberculose e conclusão do tratamento, e até resultou em taxas de adesão superiores. Isso sugere que iniciar o TPT em pacientes internados é uma estratégia viável para melhorar a cobertura em indivíduos de alto risco, após a exclusão de TB ativa.

🇧🇷 traduzido
#4

Cryptococcal dumbbell inflammatory pseudotumor mimicking skull histiocytic sarcoma in immunocompetent patient.

Surgical neurology international2026

Este artigo destaca que a criptococose, uma infecção fúngica geralmente associada a pacientes imunocomprometidos, pode, em casos raros, afetar o crânio de pessoas saudáveis. Nesses casos, a lesão pode imitar radiologicamente tumores malignos agressivos, como o sarcoma, levando a atrasos no diagnóstico. É crucial que médicos incluam infecções fúngicas no diagnóstico diferencial de lesões destrutivas do crânio, independentemente do estado imunológico do paciente, para assegurar um diagnóstico precoce e o tratamento correto.

🇧🇷 traduzido
#5

Microglia sense fungal infections through capsular components from capillary-bound Cryptococcus neoformans via endothelial nucleotide signaling.

PLoS biology2026 Feb

Este artigo revela que, na criptococose, as micróglia (células imunes do cérebro) detectam o fungo *Cryptococcus neoformans* nos capilares antes mesmo de invadir o tecido cerebral, mas, surpreendentemente, essa resposta **promove o crescimento fúngico** em vez de combatê-lo. Entender esse mecanismo – onde componentes fúngicos ativam células endoteliais a liberar sinais que "enganam" as micróglia para ajudar o fungo – oferece novas perspectivas para **desenvolver terapias antifúngicas que modulem a resposta imune do cérebro** e impeçam a progressão da doença.

🇧🇷 traduzido

Publicações recentes

Ver todas no PubMed

📚 EuropePMC3.309 artigos no totalmostrando 200

2026

Coexistence of pulmonary aspergillosis and cryptococcosis following treatment for SARS-CoV-2 infection in a kidney transplant recipient: a rare case report and literature review.

BMC nephrology
2026

Predictors of mortality among individuals with advanced HIV disease in a contemporary Brazilian cohort.

Revista panamericana de salud publica = Pan American journal of public health
2026

Antifungal activity of emodin against the Cryptococcus neoformans/Cryptococcus gattii complexes: an effect on the enzyme superoxide dismutase.

Canadian journal of microbiology
2026

Limited genome evolution of Cryptococcus neoformans following an accidental infection in the research laboratory.

ASM case reports
2026

Pulmonary Cryptococcosis Mimicking Lung Metastasis in a Patient with Pancreatic Cancer: A Case Report and Review of the Literature.

Internal medicine (Tokyo, Japan)
2026

Successful Long-Term Use of Isavuconazole in a Tacrolimus-Treated Japanese Kidney Transplant Recipient With Disseminated Cryptococcosis and Probable Invasive Aspergillosis.

Cureus
2026

Diagnosis of a patient with pulmonary and skeletal cryptococcosis: A case report and literature review.

The Journal of international medical research
2026

Current opinion on the potential role of liposomal amphotericin B in underexplored clinical scenarios.

Clinical microbiology reviews
2026

Case Report: Native aortic valve Listeria monocytogenes endocarditis in an adult with Evans syndrome.

Frontiers in immunology
2026

Case Report: The entanglement of infection and autoimmunity: a case of Caplan syndrome.

Frontiers in immunology
2026

Pulmonary cryptococcosis beyond human immunodeficiency virus: a five-year cohort study of diagnostic challenges, radiologic mimics, and clinical predictors.

Journal of thoracic disease
2026

Cryptococcus neoformans infection presenting as a mediastinal mass in an immunocompetent child with parrot exposure: a case report and literature review.

Frontiers in medicine
2026

Lumbar Puncture Frequency and Patient Survival Among Persons Hospitalized with Cryptococcal Meningitis in the United States.

Medical mycology
2026

PDE4B deficiency aids macrophage differentiation and contributes to Cryptococcus neoformans brain infection.

PLoS pathogens
2026

Evaluation of the performance of a novel chemiluminescence immunoassay for cryptococcal antigen detection.

Microbiology spectrum
2026

mGem: Progress on the development of conjugate vaccines for Cryptococcus neoformans infections.

mBio
2026

In vitro effects of IFN-γ, IL-4 and IL-27 on human bronchial epithelial cells infected with Cryptococcus neoformans sensu stricto.

Revista iberoamericana de micologia
2026

MHC-I upregulation and increased glucose dependence define innate antifungal immune responses to Cryptococcus neoformans.

The Journal of infectious diseases
2026

Strain-specific variation in virulence and host-immune modulation across the Cryptococcus gattii species complex.

International journal of medical microbiology : IJMM
2026

Pulmonary Cryptococcosis Infection in Non-HIV Patients in a Tertiary Care Center in Taiwan.

Pulmonary medicine
2026

Roles of Mutation, Ploidy, and Recombination in Adaptive Evolution in Two Divergent Model Yeasts.

Genes
2026

Potential therapeutic targets for Cryptococcus.

Medical mycology
2026

An integrative ultrastructural and transcriptomic analysis of host-pathogen interactions with human brain microvascular endothelial cells during cryptococcal infection: a preliminary study.

Frontiers in cellular and infection microbiology
2026

[A case of pulmonary cryptococcosis in dust-exposed worker].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
2026

Pretransplant serologic testing for fungal infections in a large commercial health insurance database, United States.

Medical mycology
2026

Cryptococcus neoformans responds to presence of Mycobacterium by diversifying its morphologies and remodelling its capsular material.

Journal of medical microbiology
2026

Metabolic plasticity and virulence of Cryptococcus neoformans are regulated by mitochondrial homeostasis.

bioRxiv : the preprint server for biology
2026

Presentation and prognosis of cryptococcosis requiring intensive care unit admission in France: the CRYPTO-ICU study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2026

An uncommon cancer mimic diagnosed via endobronchial ultrasound.

Breathe (Sheffield, England)
2026

The cyclin dependent kinase (CDK)7 inhibitor BS-181 inhibits pathogenic Cryptococcus species, causing G2/M arrest and a splicing defect.

Virulence
2026

Brain structural and MRI phenotypes in intracranial cryptococcosis: a comparative study based on HIV status.

BMC infectious diseases
2026

18F-FDG PET/CT in Disseminated Cryptococcosis Mimicking Malignancy With Rib Osteolysis and Chest Wall Invasion.

Clinical nuclear medicine
2026

Inhibition of the α7 nicotinic acetylcholine receptor alleviates pyroptosis in blood-brain barrier induced by Cryptococcusneoformans.

Microbial pathogenesis
2026

Antifungal repurposing of clinical chelator DMSA against Cryptococcus neoformans via laccase and histidine biosynthesis inhibition.

Microbial pathogenesis
2026

Headache as a Predictor of Cryptococcal Meningitis in Ambulatory Patients With Symptomatic HIV-associated Cryptococcal Antigenemia.

Open forum infectious diseases
2025

Phosphatidylcholine biosynthesis pathways in Cryptococcus neoformans: functional interplay and impact on virulence.

Frontiers in cellular and infection microbiology
2026

Latent Tuberculosis Infection and Cryptococcus and Rhinovirus Co-Infection in an Immunosuppressed Patient.

Clinical laboratory
2026

Intralobar pulmonary sequestration coexisting with pulmonary cryptococcosis: A case report and literature review.

Experimental and therapeutic medicine
2026

Inpatient initiation of tuberculosis preventive therapy with 1 month of isoniazid and rifapentine for adults with advanced HIV disease and cryptococcal meningitis (IMPROVE): a non-inferiority, randomised controlled trial.

The lancet. HIV
2026

One-pot recombinase polymerase amplification and CRISPR/Cas12a assay for Cryptococcus neoformans.

Applied microbiology and biotechnology
2026

Cryptococcal dumbbell inflammatory pseudotumor mimicking skull histiocytic sarcoma in immunocompetent patient.

Surgical neurology international
2026

Microglia sense fungal infections through capsular components from capillary-bound Cryptococcus neoformans via endothelial nucleotide signaling.

PLoS biology
2026

Prp8 Intein-Targeted Fluorescent Probe for Specific Detection of Cryptococcus neoformans and Inhibitor Screening.

Analytical chemistry
2026

Challenges in diagnosing cryptococcosis among HIV-infected patients in southern Mozambique and opportunities for intervention in contexts of limited resources: A pre-implementation study.

PloS one
2026

Clinical and diagnostic misperception of tuberculosis and systemic fungal infections.

Journal de mycologie medicale
2026

Two cases of refractory Cryptococcus gatti (C gatti) infection and literature review: Case report.

Medicine
2026

[Disseminated cryptococcosis resulting in fungal septic shock: a case report].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
2026

Organ-specific immune responses are strain-dependent in a mouse model of Cryptococcus neoformans brain infection.

Microbiology spectrum
2026

Development Framework of Desirability of Outcome Ranking Endpoints for Use in Clinical Trials of Invasive Fungal Diseases.

Open forum infectious diseases
2025

Diagnostic value of combined detection of cryptococcal antigen in serum and lung puncture fluid using lateral flow assay for diagnosing pulmonary cryptococcosis: a single-center prospective study.

Frontiers in microbiology
2026

Rethinking Routine Lumbar Puncture and Induction Therapy in Non-HIV Pulmonary Cryptococcosis: A Call for Risk-Based Management.

Mycopathologia
2026

Integrative Transcriptomic and Systems Biology Analyses Identify TCB1 as a Calcium-Responsive Gene in Cryptococcus neoformans.

Microorganisms
2026

Cryptococcosis in Colombia: Analysis of Data from Laboratory-Based Surveillance 2017-2024.

Journal of fungi (Basel, Switzerland)
2026

Adrenal Insufficiency due to Disseminated Cryptococcus in an Immunocompetent Individual.

Case reports in endocrinology
2025

Rare Cutaneous Presentation of Disseminated Cryptococcus gattii Infection in an Immunocompetent Male: A Case Report.

Cureus
2026

Acetylation-mediated fluconazole inactivation: A novel antifungal resistance mechanism.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
2026

Longitudinally Extensive Transverse Myelitis and Vasculitis by Cryptococcosis in a Non-HIV Patient: A Case Report.

Case reports in neurology
2025

Host-membrane lipid composition controls Cryptococcus neoformans cellular targets.

Frontiers in immunology
2026

Serum cryptococcal antigen gradient detection for monitoring the efficacy and medical guidance of the treatment of pulmonary cryptococcosis: a case report.

BMC infectious diseases
2026

Parasitic and fungal central nervous system infections in hospitalised adults living with HIV in Libreville, Gabon: clinical profiles to inform syndromic triage in resource limited settings.

AIDS research and therapy
2026

Pulmonary Fungal Infections in the Immunocompetent Host.

Chest
2026

Probable disseminated cryptococcosis relapse in a patient with Hodgkin's lymphoma treated with induction therapy resumption and autologous stem cell transplant.

Journal de mycologie medicale
2026

Temperature and genetic background drive mobilization of diverse transposable elements in a global human fungal pathogen.

PLoS genetics
2026

Conjugation of a Cryptococcus neoformans-derived metalloprotease to antifungal-loaded PLGA nanoparticles treats neural cryptococcosis in an in vitro model.

PloS one
2026

Research priorities for advanced HIV disease in Latin America and the Caribbean region: a modified Delphi study.

Journal of the International AIDS Society
2026

Pulmonary Cryptococcosis in an Immunocompetent Patient: Negative mNGS but Positive Antigen Test.

Clinical laboratory
2026

When an Adrenal Mass Isn't Cancer: A Rare Case of Mycobacterium genavense Mimicking a Neuroendocrine Tumor.

JCEM case reports
2026

Cryptococcal antigen titers and semi-quantitative assay scores among people with HIV-associated cryptococcal antigenemia.

Journal of clinical microbiology
2026

Constrictive Pericarditis Due to Cryptococcus Neoformans in an Elderly Immunosuppressed Patient.

European journal of case reports in internal medicine
2026

Cryptococcus neoformans causing localised osteomyelitis of the right anterior rib.

BMJ case reports
2026

Occult cryptococcal meningitis presenting as myelopathy from an arachnoid cyst.

BMJ case reports
2026

Fatal Outcome due to Disseminated Cryptococcosis in a Patient With HIVrequiring Veno-Arterial Extracorporeal Membrane Oxygenation: A Case Report.

Acute medicine &amp; surgery
2026

Successful desensitization to liposomal amphotericin B for the treatment of disseminated cryptococcosis in pregnancy: a case report.

ASM case reports
2026

Clinical spectrum, immune status, and prognostic factors of cryptococcosis: insights from a large, multi-center, ambispective cohort study in southeastern China.

Infectious diseases of poverty
2025

CsDETC: detection and counting of small target Cryptococcus spp.

Frontiers in cellular and infection microbiology
2025

Clinicopathological Features, Treatment Outcome, and the Cryptococcal Antigen Latex Agglutination System Titer in Feline Cryptococcosis Treated with Amphotericin B and Fluconazole.

Veterinary sciences
2026

Point-of-Need Test of Cryptococcus Utilizing Aggregation-induced Emission-based Lateral Flow Immunoassay.

Analytical chemistry
2025

Prevalence of Cryptococcal Antigenemia Among Human Immunodeficiency Virus Infection or Acquired Immunodeficiency Syndrome Patients Attending the Retroviral Clinic in University of Maiduguri Teaching Hospital.

Nigerian journal of clinical practice
2025

A conserved enzymatic toolkit targeting host cell metabolism is associated with Cryptococcus neoformans intracellular survival in protozoal and mammalian phagocytic cells.

PLoS pathogens
2025

Vaccine-Mediated Protection of Mice Against African and Asian Clinical Strains of Cryptococcus neoformans.

Journal of fungi (Basel, Switzerland)
2025

An Emerging Infectious Yeast to Watch: Cryptococcus gattii Species Complex.

Journal of fungi (Basel, Switzerland)
2025

Unusual Neuropsychiatric Presentation of Cryptococcus neoformans Meningoencephalitis in an Immunosuppressed Patient with Rheumatoid Arthritis: A Case Report.

Diseases (Basel, Switzerland)
2026

Cryptococcid Sweet Syndrome in the Setting of Hydralazine-Induced ANCA Vasculitis: A Case Report.

Journal of cutaneous pathology
2025

Primary Cutaneous Cryptococcosis Mimicking Vasculitis in a Patient with Rheumatoid Arthritis.

The new microbiologica
2025

[Indole-3-acetic acid alleviates Cryptococcus neoformans-induced pyroptosis in cerebral microvascular endothelial cells by regulating stress granule-mediated NLRP3 inflammasome activation].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University
2025

Development of a Multiplex qPCR to Detect and Identify Cryptococcus neoformans and Cryptococcus gattii.

ACS omega
2025

Cryptococcal immune reconstitution inflammatory syndrome: Cutaneous clues to disseminated cryptococcosis in a human immunodeficiency virus patient coinfected with tuberculosis on antiretroviral therapy.

Indian journal of sexually transmitted diseases and AIDS
2025

Cryptococcal Infection in a Patient With Chronic Lymphocytic Leukaemia Receiving Acalabrutinib, a Bruton's Tyrosine Kinase Inhibitor: A Case Report.

Cureus
2025

Multifocal Intracranial Cryptococcoma with Treatment Resistance, Recurrence, and Mortality: A Case Report and Literature Review.

NMC case report journal
2025

The catalase gene CAT2 and its role in the virulence of one sub-cluster of Cryptococcus gattii VGI clinical isolates.

Acta biochimica et biophysica Sinica
2025

In vitro and in vivo efficacy of the antimycobacterial molecule SQ109 against the human pathogenic fungus, Cryptococcus neoformans.

PLoS neglected tropical diseases
2025

Dormant yet dangerous: the role of cell rest in perseverance.

Future microbiology
2026

Bilateral Multifocal Cutaneous Panniculitis in a Kidney Transplant Patient With a History of Successfully Treated Cryptococcal Meningitis: A New Clinical Presentation of Localized Subcutaneous Cryptococcosis.

Transplant infectious disease : an official journal of the Transplantation Society
2025

Cytometric Analysis of CD3 + CD4 + T Populations and Activation and Regulation Status of Naïve and Memory CD4 + CD45RA T Cells in Immunocompetent Patients with Neurocryptococcosis.

Mycopathologia
2025

Intracellular C. neoformans infection stimulates increased glycolytic activity in fetal liver-derived alveolar-like macrophages.

bioRxiv : the preprint server for biology
2025

Evaluation of routine screening for early detection of Histoplasma and Cryptococcus antigens in CD4-referred blood specimens in Colombia: A prospective study of prevalence and geographic distribution.

Medical mycology
2025

Pulmonary cryptococcosis coexisting with lung cancer: a Chinese multicenter retrospective study.

Quantitative imaging in medicine and surgery
2025

Mp1p antigen as a sensitive diagnostic marker for early detection and treatment monitoring of Talaromyces Marneffei infection.

BMC immunology
2025

[Clinical practice guidelines for the diagnosis and management of invasive pulmonary fungal diseases (2025 Edition)].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
2025

Reactive oxygen species drive the aberrant immune response to a C. neoformans chitin synthase 3 (chs3Δ) mutant.

Frontiers in immunology
2025

In toto imaging shows intravascular proliferation promotes transmigration of daughter cells during brain invasion of Cryptococcus neoformans.

Cell reports
2026

Evaluation of a lateral flow immunochromatographic assay for detecting cryptococcal antigens in bronchoalveolar lavage fluid from HIV-negative patients with pulmonary cryptococcosis.

Microbiology spectrum
2025

Hybrid genome sequence of Cryptococcus neoformans of Indian origin and comparative genome analysis.

Scientific reports
2025

Laryngeal cryptococcosis.

The American journal of medicine
2025

[The Chinese guidelines for the diagnosis and treatment of invasive fungal disease in patients with hematological disorders and cancers (the seventh revision)].

Zhonghua nei ke za zhi
2025

Exploring therapeutic targets for cryptococcosis: in silico and in vitro testing for isocitrate lyase (ICL1) potential inhibitors.

Journal of computer-aided molecular design
2025

Cryptococcus exploits delayed microglial activation, and microglial osteopontin/Spp1 impairs peripheral host control.

Cell host &amp; microbe
2026

Cryptococcosis in kidney transplant recipients: Pathogenesis, clinical challenges, and evolving therapeutic strategies.

Transplantation reviews (Orlando, Fla.)
2025

From neglected to notable: A growing public health challenge driven by hospitalization for sporotrichosis in Pernambuco, Northeast Brazil (2016-2024).

PLoS neglected tropical diseases
2026

Mannoprotein Cig1 contributes to the immunogenicity of a heat-killed F-box protein Fbp1 Cryptococcus neoformans vaccine model.

Infection and immunity
2025

[Central nervous system vasculitis in immunocompetent patients with cryptococcal meningitis].

Medicina
2026

Isolation of Cryptococcus gattii (genotype VGI) from a specimen of Pinus. An approach to its natural habitat in México City.

Revista iberoamericana de micologia
2025

The very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase Phs1 regulates ATP levels and virulence in Cryptococcus neoformans.

BMC microbiology
2026

Second generation repurposing of phenothiazine antipsychotic drugs as antifungal lead molecules via optimization of phenoxazine derivatives.

European journal of medicinal chemistry
2025

Web-Based Dashboard for Tracking Cryptococcosis-Related Deaths in Brazil (2000-2022).

Tropical medicine and infectious disease
2025

Colonization of the central nervous system as a key factor in the Cryptococcus gattii pathogenicity.

Virulence
2025

Capsular polysaccharides from Cryptococcus neoformans suppress cancer through apoptosis and immune cell activation.

International immunopharmacology
2026

Central nervous system cryptococcosis with brain stem hemorrhage during chemotherapy for pediatric acute myeloblastic leukemia patient.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
2025

Polystyrene nanoparticles reduce the Cryptococcus neoformans virulence via induction of mitochondrial dysfunction.

Frontiers in cellular and infection microbiology
2025

Isolation of Naganishia diffluens (formerly Cryptococcus diffluens) from skin lesions of a patient with leukemia.

Revista iberoamericana de micologia
2025

Case Report: A Pulmonary Cryptococcosis Presenting as Interstitial Pneumonia in a Patient of IgA Nephropathy.

Infection and drug resistance
2025

Oral L-Arginine treatment attenuates Cryptococcus neoformans extrapulmonary dissemination and disease progression.

Virulence
2025

Challenges in the management of intracranial hypertension in pediatric patients with HIV: a case report.

Frontiers in medicine
2025

Effectiveness of voriconazole therapy for pulmonary cryptococcosis in fluconazole treatment failure: a multicenter real-world study.

BMC infectious diseases
2025

Balloon dilatation for bronchoscope delivery: first-in-human trial of a novel technique for peripheral lung field access.

Thorax
2025

Rapid respiratory cryptococcosis detection using targeted next-generation sequencing.

PLoS neglected tropical diseases
2025

Cryptococcosis in patients with myasthenia gravis: clinical characteristics and management strategy.

Frontiers in cellular and infection microbiology
2025

A fatal case of chronic Cryptococcus neoformans meningitis progressing over a 4-year period following cladribine therapy.

ASM case reports
2025

Impact of Cryptococcosis on the Immune Recovery of Patients with AIDS and Severe Immunosuppression.

Mycopathologia
2025

Disseminated cryptococcosis involving the adrenal gland and brain in an immunocompetent patient: A case report.

Medicine
2025

Disseminated Cryptococcosis: A Diagnostic Challenge in an Immunocompromised Patient.

European journal of case reports in internal medicine
2025

Prevalence and risk factors of adverse drug events with dolutegravir-based regimens among Thai people living with HIV: a retrospective cohort study.

AIDS research and therapy
2025

Metagenomic next-generation sequencing facilitates precision treatment and prognostic improvement in pulmonary cryptococcosis.

Frontiers in cellular and infection microbiology
2025

Eyelid Ptosis as an Atypical Manifestation of Meningeal Cryptococcosis: A Case Report.

Cureus
2025

Unusual cutaneous manifestations of disseminated Cryptococcus gattii infection in an immunocompetent host.

Revista do Instituto de Medicina Tropical de Sao Paulo
2025

Invasive fungal infections in the Nigerian paediatric population: A systematic review.

Journal de mycologie medicale
2025

Target product profile and discovery and development path for novel cryptococcal disease treatments.

The Journal of infection
2025

Cryptococcus neoformans phospholipase B1 is critical for cryptococcoma formation in the mouse brain.

Frontiers in immunology
2025

An 80-year-old man with a rare disease manifestation of disseminated cryptococcosis.

IDCases
2025

The Capsular Polysaccharides GXM and GXMGal from Cryptococcus neoformans Modulate Macrophages Infected with Leishmania major.

Microorganisms
2025

Progression of Pulmonary Cryptococcosis Refractory to Antifungal Therapy.

American journal of respiratory and critical care medicine
2025

Optimizing antifungal dosing for invasive Cryptococcus infections: minimum inhibitory concentration distributions and pharmacokinetic/pharmacodynamic insights from 2010-2023 Antimicrobial Testing Leadership and Surveillance data.

Frontiers in pharmacology
2025

Unexpected variability in laboratory and clinical assays used to quantify Cryptococcus neoformans polysaccharide.

The Journal of infectious diseases
2025

Cryptococcus displays spore-specific uptake by alveolar epithelial cells.

mBio
2025

Involuntary Movement Disorders in Central Nervous System Fungal Infections: A Systematic Review.

Movement disorders clinical practice
2025

Disseminated cryptococcosis in an HIV patient with hepatitis C as the associated risk factor.

Current medical mycology
2025

Reconsidering the blood-brain barrier: histopathology and microanatomy of cryptococcal CNS infection.

Microbiology and molecular biology reviews : MMBR
2026

Canine meningitis and meningoencephalitis in eastern Australia.

Australian veterinary journal
2025

Molecular epidemiology and antifungal susceptibilities of Cryptococcus neoformans in bird droppings from zoological gardens and public places in Peninsular Malaysia.

Tropical biomedicine
2025

Cryptococcal Meningitis Without Headache: A Case Report Highlighting an Atypical Presentation.

Cureus
2026

Major revision version 13.0 of the European AIDS Clinical Society guidelines 2025.

HIV medicine
2025

Estimated burden of serious mycoses in Poland.

Scientific reports
2025

Disseminated cryptococcosis presenting as lung mass.

BMJ case reports
2025

Unisexual reproduction in the global human fungal pathogen Cryptococcus neoformans.

Proceedings of the National Academy of Sciences of the United States of America
2025

Whole Blood Proteome Dynamics Defines Predictive Diagnostic and Prognostic Signatures of Cryptococcal Infection.

Molecular &amp; cellular proteomics : MCP
2026

Diagnostic performance of lateral flow antigen tests versus latex agglutination for cryptococcosis in dogs and cats.

American journal of veterinary research
2025

Predictive value of C-reactive protein for hospitalization and mortality among people with advanced HIV disease in Uganda receiving the WHO-recommended package of care.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2025

Postpartum pulmonary cryptococcosis combined with pulmonary embolism: a case report.

BMC pulmonary medicine
2025

Corrigendum to "Lung-resident memory Th2 cells regulate pulmonary cryptococcosis by inducing type-II granuloma formation" [Mucosal Immunol. 18(3) (2025) 631-642].

Mucosal immunology
2025

Transcriptomic profiling of lung alveolar macrophages reveals distinct contribution of sterol metabolism in macrophage response to Cryptococcus gattii infection.

PloS one
2025

Effects of simulated microgravity on biological features and virulence of the fungal pathogen Cryptococcus neoformans.

Applied and environmental microbiology
2025

Can liposomal amphotericin B be used as a preventive measure for cryptococcal meningitis?

Expert review of anti-infective therapy
2025

Primary Orbital Cryptococcosis in an Immunocompetent Child: A Case Report.

Ophthalmic plastic and reconstructive surgery
2025

Cryptococcus neoformans serotype A virulence and pathogenicity are capsular glucuronoxylomannan (GXM) motif composition dependent.

mBio
2025

Cryptococcal infection: host immunity, immune evasion and emerging immunotherapeutic strategies.

Frontiers in cellular and infection microbiology
2025

Evaluating the diagnostic efficacy of metagenomic next-generation sequencing in bronchoalveolar lavage fluid for pulmonary cryptococcosis with different clinical and imaging characteristics.

BMC infectious diseases
2025

Cryptococcus neoformans tibial osteomyelitis in an immunocompetent host: a case diagnosed by tNGS.

BMC infectious diseases
2025

Report of a feline Cryptococcus neoformans infection in Hungary.

Acta veterinaria Hungarica
2025

What Do We Know About Cryptococcus spp. in Portugal? One Health Systematic Review in a Comprehensive 13-Year Retrospective Study (2013-2025).

Journal of fungi (Basel, Switzerland)
2025

Non-Tuberculous Laryngeal Granulomas: Systematic Review and Case Series.

ANZ journal of surgery
2025

Cryptococcus gattii Infection in the Carpal Joint of a Goat.

Veterinary clinical pathology
2025

Advancing antifungal therapy: exploring targeted CFW-PEc-enhanced ethosomal formulations of amphotericin B against cryptococcal pneumonia.

Microbiology spectrum
2025

Global proteomic analysis of Cryptococcus neoformans clinical strains reveals significant differences between latent and lethal infection.

mSystems
2025

The Pain Is in the Brain With the Sugar-Coated Killer.

The Journal of infectious diseases
2025

Induction of pan-azole resistance in Cryptococcus neoformans by agrochemical azole uniconazole through upregulation of efflux and chromosomal disomies.

Frontiers in cellular and infection microbiology
2026

Adrenal Corticosteroids and Increased Intracranial Pressure in Nonimmunocompromised Patients With Cryptococcal Meningitis.

The Journal of infectious diseases
2025

Immunomodulatory effects of Cryptococcus neoformans capsular polysaccharides on macrophage infected with Trypanosoma cruzi.

Acta tropica
2025

Insights from Mass Spectrometry-Based Proteomics on Cryptococcus neoformans.

Journal of fungi (Basel, Switzerland)
2025

Shifting epidemiology and microbiological profiles of cryptococcosis in a Brazilian tertiary center: A descriptive study of 94 patients.

Revista iberoamericana de micologia
2025

pCramoll therapy decreases mortality and fungal burden in immunosuppressed mice infected with Cryptococcusgattii.

Microbial pathogenesis
2025

Disseminated Cryptococcosis With Multifocal Osteomyelitis Presenting as a Non-Healing Ulcer in a Kidney Transplant Recipient.

Transplant infectious disease : an official journal of the Transplantation Society
2026

Evaluation of the semi-quantitative BIOSynex® CryptoPS test in serum and cerebrospinal fluid samples of patients with cryptococcosis diagnosed through the IMMY CrAg® lateral flow assay: a translational study.

Diagnostic microbiology and infectious disease
2025

Deubiquitinase Ubp5 is essential for pulmonary immune evasion and hematogenous dissemination of Cryptococcus neoformans.

Mycology
2025

A novel arylnaphthalene lignan analogue targets CYP51 to inhibit Cryptococcus neoformans growth.

Bioorganic chemistry
2026

Acute Toxicity and Genotoxicity of cMoL, a Lectin From Moringa oleifera Seeds With Antifungal Activity Against Cryptococcus Strains.

Journal of applied toxicology : JAT
2025

Effects of novel organoantimony compounds on the fungal pathogen Cryptococcus neoformans.

Journal of medical microbiology
2025

Naganishia albidus Causing Perioral Cutaneous Infection: A Rare Case Easily Misdiagnosed.

Infection and drug resistance
2025

Addison's disease due to adrenal insufficiency in an immunocompetent patient with disseminated cryptococcosis. Case report.

Revista peruana de medicina experimental y salud publica
2025

Genomic Evidence for a-α Heterothallic and α-α Unisexual Mating and Recombination in an Environmental Cryptococcus deneoformans Population.

bioRxiv : the preprint server for biology
2025

Mediastinal cryptococcoma as part of disseminated cryptococcosis in HIV-negative pregnant woman with Myasthenia Gravis: Autopsy case report.

Medical mycology case reports
2025

Rare Case of Systemic Cryptococcal Lymphadenopathy in a Persian Cat.

Veterinary medicine and science
2025

Ubiquitin degradation of the Ribonuclease H2 subunit B Rnh2B regulates the virulence of Cryptococcus neoformans.

Virulence
2025

Bone marrow cryptococcosis in an HIV-infected patient: A case report and literature review.

Journal de mycologie medicale
2025

Cgm1 is a β-galactoside α-(1 → 4)-mannosyltransferase involved in the biosynthesis of capsular glucuronoxylomannogalactan in Cryptococcus neoformans.

The Journal of biological chemistry
2025

A method for authenticating the fidelity of Cryptococcus neoformans knockout collections.

Microbiology spectrum
2025

A case of humidifier lung potentially caused by Cryptococcuslaurentii.

Respiratory investigation
2025

The outcomes of cryptococcal disease in HIV-positive individuals following COVID-19 infection: A systematic review and meta-analysis.

Journal of infection and public health
2025

The Role of Nutritional Environment in Cryptococcus gattii Titan Cells' Ultrastructure, Biophysical Properties, Molecular Features, and Virulence in Cryptococcosis.

Infectious disease reports
2025

Development of a multiplex-PCR assay for differentiation of Cryptococcus species using the PRP8 gene region.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
2025

Puf4 -mediated oxidative stress virulence attenuation in Cryptococcus neoformans.

Frontiers in cellular and infection microbiology
Ver todos os 3.309 no EuropePMC

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. PDE4B deficiency aids macrophage differentiation and contributes to Cryptococcus neoformans brain infection.
    PLoS pathogens· 2026· PMID 41805786mais citado
  2. An integrative ultrastructural and transcriptomic analysis of host-pathogen interactions with human brain microvascular endothelial cells during cryptococcal infection: a preliminary study.
    Frontiers in cellular and infection microbiology· 2026· PMID 41736794mais citado
  3. Inpatient initiation of tuberculosis preventive therapy with 1 month of isoniazid and rifapentine for adults with advanced HIV disease and cryptococcal meningitis (IMPROVE): a non-inferiority, randomised controlled trial.
    The lancet. HIV· 2026· PMID 41662846mais citado
  4. Cryptococcal dumbbell inflammatory pseudotumor mimicking skull histiocytic sarcoma in immunocompetent patient.
    Surgical neurology international· 2026· PMID 41660350mais citado
  5. Microglia sense fungal infections through capsular components from capillary-bound Cryptococcus neoformans via endothelial nucleotide signaling.
    PLoS biology· 2026· PMID 41650189mais citado
  6. Editorial: Targeting major human fungal pathogens: novel insights into virulence and antifungal therapies.
    Front Cell Infect Microbiol· 2026· PMID 41987900recente
  7. Emerging cryptococcosis cases in Himalayan & sub-Himalayan regions of India.
    New Microbes New Infect· 2026· PMID 41971398recente
  8. [Pulmonary cryptococcosis in a non-HIV patient].
    Medicina (B Aires)· 2026· PMID 41961617recente
  9. Invasive Fungal Infections Following Bruton Tyrosine Kinase Inhibitor Treatment: A Systematic Review and Meta-analysis.
    Blood Adv· 2026· PMID 41954633recente
  10. Descriptive epidemiology of opportunistic infections among patients with advanced HIV disease in Kinshasa, Democratic Republic of Congo.
    BMC Infect Dis· 2026· PMID 41933288recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:1546(Orphanet)
  2. MONDO:0005724(MONDO)
  3. GARD:6218(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q1470140(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Criptococose
Compêndio · Raras BR

Criptococose

ORPHA:1546 · MONDO:0005724
Prevalência
Unknown
Herança
Not applicable
CID-10
B45.1 · Criptococose cerebral
CID-11
Ensaios
2 ativos
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0010414
EuropePMC
Wikidata
Wikipedia
Papers 10a
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