Raras
Buscar doenças, sintomas, genes...
Doença de Lyme
ORPHA:91546CID-10 · A69.2CID-11 · 1C1GDOENÇA RARA

A Doença de Lyme (que recebeu esse nome das cidades nos Estados Unidos onde foi descoberta pela primeira vez) é uma infecção bacteriana causada pela bactéria Borrelia burgdorferi.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

A Doença de Lyme (que recebeu esse nome das cidades nos Estados Unidos onde foi descoberta pela primeira vez) é uma infecção bacteriana causada pela bactéria Borrelia burgdorferi.

Pesquisas ativas
22 ensaios
124 total registrados no ClinicalTrials.gov
Publicações científicas
10.597 artigos
Último publicado: 2026 Mar

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Europe
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: A69.2
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

❤️
Coração
2 sintomas
🧠
Neurológico
2 sintomas
💪
Músculos
2 sintomas
🫃
Digestivo
1 sintomas
🛡️
Imunológico
1 sintomas
🧬
Pele e cabelo
1 sintomas

+ 13 sintomas em outras categorias

Características mais comuns

55%prev.
Meningite
Frequente (79-30%)
55%prev.
Paralisia de nervo craniano
Frequente (79-30%)
55%prev.
Artrite
Frequente (79-30%)
55%prev.
Inchaço articular
Frequente (79-30%)
17%prev.
Uveíte
Ocasional (29-5%)
17%prev.
Arritmia
Ocasional (29-5%)
24sintomas
Frequente (4)
Ocasional (20)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 24 características clínicas mais associadas, ordenadas por frequência.

MeningiteMeningitis
Frequente (79-30%)55%
Paralisia de nervo cranianoCranial nerve paralysis
Frequente (79-30%)55%
ArtriteArthritis
Frequente (79-30%)55%
Inchaço articularJoint swelling
Frequente (79-30%)55%
UveíteUveitis
Ocasional (29-5%)17%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico10.597PubMed
Últimos 10 anos200publicações
Pico2026124 papers
Linha do tempo
2026Hoje · 2026🧪 1996Primeiro ensaio clínico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
Aprovado1
3Fase 32
2Fase 24
1Fase 11
·Pré-clínico12
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 20 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Doença de Lyme

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

18 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

NCT06785402 · Ceftriaxone for Post-Treatment Lyme DiseaseRecrutando
PHASE1, PHASE2
NCT00001539 · A Comprehensive Clinical, Microbiological and Immunological …Recrutando
NCT06611111 · Ceftriaxone Pulse Dose for Post-Treatment Lyme DiseaseRecrutando
EARLY_PHASE1
NCT00028080 · Evaluation, Treatment, and Follow-up of Patients With Lyme D…Recrutando
NCT06511050 · Lumbrokinase for Adults With Long Covid, Post-treatment Lyme…Recrutando
PHASE1, PHASE2
NCT04402086 · Rheumatology Patient Registry and BiorepositoryRecrutando
NCT04806620 · Unhide® Project: A Digital Health Platform to Collect Lifest…Recrutando
NCT06655844 · Sana Device for Post-Treatment Lyme Disease Syndrome Chronic…Recrutando
NA
NCT05776251 · taVNS for Persistent Symptoms From Lyme DiseaseRecrutando
NA
NCT06451913 · Effect of Saccharomyces Boulardii CNCM I-745 on Gut Microbio…Recrutando
PHASE4
NCT06915324 · Transcranial Direct Current Stimulation for Post Treatment L…Recrutando
NA
NCT06397794 · Navigating Pregnancy and Parenthood With Lyme DiseaseRecrutando
NCT01793168 · Rare Disease Patient Registry & Natural History Study - Coor…Recrutando
NCT05036707 · Human Immune Response to Ixodes Scapularis Tick BitesRecrutando
PHASE1, PHASE2
NCT06045416 · Borrelia B-cell DiagnosticsRecrutando
NCT06026969 · Pregnancy and Early Neurodevelopmental Outcomes Following In…Recrutando
NCT05219929 · Tetracycline Treatment Tolerability TrialPor convite
PHASE2
NCT06583395 · Quest to Analyze One Thousand Humans MeditatingPor convite

Outros ensaios clínicos

124 ensaios clínicos encontrados, 22 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
4.170 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 4.170

#1

An Fc-silent OspA monoclonal antibody passively protects mice from tick and intradermal Borrelia burgdorferi challenge.

PloS one2026

The monoclonal antibody, LA-2, has played a pivotal role in the development of Outer surface protein A (OspA)-based vaccines for Lyme disease, a multisystem illness caused by the tick-borne spirochete, Borrelia burgdorferi sensu lato. Of particular significance was the demonstration more than three decades ago that LA-2 equivalent antibody titers, defined by a competitive-inhibition ELISA, serve as a reliable correlate of vaccine-induced protection across different species, including humans. In vitro characterization of LA-2 has identified both complement-dependent and -independent activities, although which of these attributes contribute to protection against B. burgdorferi remains unresolved. To address this issue, we generated and characterized an "Fc-silent" version of LA-2 IgG1 carrying so-called LALAPG substitutions (L234A, L235A, P329G). We demonstrate that LA-2 LALAPG retained OspA binding activity but was severely attenuated in in vitro complement deposition and complement-dependent borreliacidal assays. Nonetheless, LA-2 LALAPG was as effective as LA-2 at passively protecting C3H mice against nymphal tick-mediated B. burgdorferi sensu stricto (s.s.) B31 challenge. LA-2 LALAPG was also equivalent to LA-2 in passively protecting BALB/c mice against intradermal B. burgdorferi s.s. B31 challenge. In the intradermal challenge model, viable spirochetes were not recoverable 24 h after injection from skin biopsies of mice treated with LA-2 or LA-2 LALAPG, and an influx of pro-inflammatory cytokines and chemokines to the injection site was abrogated. Collectively, these results suggest that LA-2's primary mode of action involves direct physical interactions with the spirochete rather than complement-dependent killing. Elucidating these mechanisms may have implications for understanding the mechanistic correlates of OspA-based vaccine-induced immunity in humans.

#2

Feasibility of an adjunctive INtervention for Debilitating symptom complexes attributed to ticks (FIND): study protocol for a randomised, waitlist-controlled feasibility trial.

BMJ open2026 Mar 10

Debilitating Symptom Complexes Attributed to Ticks (DSCATT) is a new term for an unexplained Australian syndrome-people who suffer from a chronic, multifaceted and debilitating illness, characteristically attributed to tick bites, but in a country without endemic Lyme disease. Despite the profound morbidity of DSCATT, no single causative agent has been identified and there are no recognised treatments for the illness at present. An increasing body of evidence shows psychological therapies such as Acceptance and Commitment Therapy (ACT) can be effective in reducing symptom-related disability and improving quality of life for other unexplained syndromes. Here we present a study protocol to assess the feasibility of an ACT-informed intervention for patients suffering from DSCATT, to be used adjunctively to their pre-existing healthcare. The study aims to assess the acceptability, practicality and demand for the treatment. Additionally, we will examine the effects of therapy on participants' health and well-being, its safety, potential mediators of response to therapy and its preliminary cost-effectiveness. We will assess the feasibility of a 32-week, randomised, waitlist-controlled, parallel convergent mixed-methods pilot trial for DSCATT. Participants will be randomised in a 1:1 ratio to receive either 16 sessions of ACT-informed therapy adjunctive to their pre-existing healthcare, delivered one-to-one with a trial therapist within a 20-week period or be assigned to the waitlist control group where they will continue their treatments as usual. We will collect quantitative and qualitative data to address study aims, with retention rate being the primary feasibility outcome. The study has ethical approval from Austin Health Human Research Ethics Committee (HREC). The outcomes will be published in peer-reviewed journals. Data from participants who have given extended consent will be available for other HREC-approved studies. ACTRN12623000372684, prospectively registered 13 April 2023, URL: https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=385579&isReview=true; the last participant is expected to complete in November 2026.

#3

Non-invasive ovulation tracking enables genetic engineering in wild rodents.

Cell reports methods2026 Feb 23

Many non-model rodent species are inaccessible to genetic engineering due to our limited understanding of their reproductive biology. Here, we present a low-cost, camera-based estrous-tracking technology that enables transgenesis in the white-footed mouse Peromyscus leucopus, a key reservoir for Lyme disease. We demonstrate the efficient generation of pregnant and pseudopregnant mice via timed ovulation, provide protocols for embryo generation, cultivation, microinjection, and transplantation as well as an accurate developmental timeline, and report the first engineered Peromyscus. The same technology successfully tracked conserved estrous-linked cycling behavior in other rodents, including hamsters. Finally, estrous tracking differentiated reproductively healthy, geriatric female Peromyscus from those with declining fertility based solely on their activity, providing a non-invasive method for studying reproductive senescence. Collectively, these tools represent a critical resource for engineering non-model rodents, advance the long-lived Peromyscus as a model organism, and will prove essential to heritably immunizing wild rodent populations against Lyme disease.

#4

Exploring Cerebrovascular Manifestations of Neuroborreliosis: A Scoping Review.

Annals of Indian Academy of Neurology2026 Jan 01

Lyme disease is zoonotic infection transmitted by Borrelia burgdorferi and, if left undiagnosed, can present in later stages with neurological manifestations. This review aims to consolidate evidence on stroke-like or similar cerebrovascular outcomes of Lyme neuroborreliosis (LNB) to aid early recognition and treatment. A comprehensive search resulted in 90 patients meeting European Federation of Neurological Societies/Infectious Diseases Society of America/ American Academy of Neurology/American College of Rheumatology (EFNS/IDSA/AAN/ACR) criteria for LNB with radiologically or serologically confirmed cerebrovascular involvement. Data were charted descriptively. Median age was 12 years among children and 52 years in adult cases. Tick exposure was reported in 89% of cases. Presentations included hemiparesis (51%), cranial-nerve palsy (38%; Lower Motor Neuron (LMN) facial 31%), and cognitive changes (26%). Common imaging findings were vasculitis (72%) and ischaemic stroke (51%), mainly in the cortical (56%) area. Cerebrospinal fluid (CSF) lymphocytic pleocytosis (median 73 cells/µL) with presence of intrathecal Borrelia Immunoglobulin G (IgG) appeared in the majority of cases. Antibiotics (mainly ceftriaxone) were used in 85% of cases and interventional management in 13% of cases. Ninety percent of cases improved after 6 months of treatment. Mortality and persistent tetraplegia were reported in 5% and 3% of cases, respectively. LNB should be suspected in cases of cryptogenic stroke from endemic areas. Reduction in CSF pleocytosis with intrathecal Borrelia antibodies could predict a favorable antibiotic response, although some refractory cases were observed to improve only with interventional management. Prompt diagnosis and management can affect morbidity and mortality.

#5

Telomere-to-telomere assembly detects genomic diversity in Canadian strains of Borrelia burgdorferi.

Cell reports2026 Feb 24

Borrelia burgdorferi, the bacteria causing Lyme disease, has a complex genome comprising a linear chromosome and multiple linear and circular plasmids. The atypical hairpin telomeres and the highly paralogous plasmids complicate genome assembly. We develop a genome assembly pipeline using both long and short reads to overcome these challenges. Using long reads, we assemble the hairpin telomeres of the linear replicons, an lp28-1a plasmid subtype, and circular plasmids of nine B. burgdorferi strains from five regions across Northwest Ontario and Manitoba, Canada. Although similar across the core conserved genomic regions, all strains carry a ∼2-10 kb right telomeric end identical to lp28-1, leading to variability in telomere length and gene content. Additionally, we observe diversity at the linear chromosome hairpin telomeric sequences, ospC types, and plasmid profiles, highlighting the genomic diversity among the geographically proximate strains and suggesting such variations as possible mechanisms of rapid evolution.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC5.850 artigos no totalmostrando 199

2026

Ticks in the Tropics: Challenging the Myth of a Lyme-Less Florida.

Public health reports (Washington, D.C. : 1974)
2026

Peridomestic and Neighborhood-Level Deciduous Land Cover Associated with Lyme Disease Risk: Results from a Case-Control Study in the United States.

Vector borne and zoonotic diseases (Larchmont, N.Y.)
2026

The Hidden Face of Lyme Disease: Neuroinfection With Cranial Nerve Involvement.

Cureus
2026

Homologous and Heterologous Immunization with a PIV5-Based Modified OspA Vaccine Confers Equivalent Protection Against Tick-Transmitted Borrelia burgdorferi.

bioRxiv : the preprint server for biology
2026

High-grade Atrioventricular Block Due to Disseminated Lyme Disease Requiring Permanent Pacemaker Implantation.

US cardiology
2026

Liver abscess as a complication of acute Lyme disease: a case report.

Frontiers in medicine
2026

Surveillance for Ixodes scapularis and Ixodes pacificus ticks and their associated pathogens in Canada, 2022.

Canada communicable disease report = Releve des maladies transmissibles au Canada
2026

Surveillance for Ixodes scapularis and Ixodes pacificus ticks and their associated pathogens in Canada, 2021.

Canada communicable disease report = Releve des maladies transmissibles au Canada
2026

Epidemiology of tick-borne diseases diagnosed in patients in north-eastern Italy, 2015-2022.

BMC infectious diseases
2026

Natural genetic variation impacts complement inhibitory activity of PFam54 orthologs of Asian Borrelia bavariensis.

Scientific reports
2026

Evaluation of immunoreactive epitopes in the sera and cerebrospinal fluid of patients with post-treatment Lyme disease syndrome.

Scientific reports
2026

An Fc-silent OspA monoclonal antibody passively protects mice from tick and intradermal Borrelia burgdorferi challenge.

PloS one
2026

Unraveling the long-term consequences of antenatal SARS-CoV-2 infection on early childhood neurodevelopment.

Pediatric research
2026

Efficacy of Simparica and Simparica TRIO for the prevention of Borrelia burgdorferi by Ixodes scapularis.

Parasites &amp; vectors
2026

Feasibility of an adjunctive INtervention for Debilitating symptom complexes attributed to ticks (FIND): study protocol for a randomised, waitlist-controlled feasibility trial.

BMJ open
2026

The Borreliella burgdorferi BosR-associated small non-coding RNA BasA regulates virulence.

Infection and immunity
2026

Demographic Predictors of Lyme Disease Knowledge Among Parents in a Highly Endemic Area.

Vector borne and zoonotic diseases (Larchmont, N.Y.)
2026

Persistent bradycardia requiring temporary pacing in a young adult with lyme carditis: a case report.

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology
2026

Feasibility and preliminary efficacy of an online yoga program for managing symptoms of post-treatment lyme disease syndrome.

Complementary therapies in medicine
2026

Association between spirochaetal infection and neurodegenerative diseases: a systematic review and quantitative synthesis of observational studies.

Journal of medical microbiology
2026

A pseudochromosomal reference genome of the golden jackal, Canis aureus.

The Journal of heredity
2026

A complex case of chronic cutaneous Borrelia burgdorferi sensu stricto infection manifesting as morphea-like sclerosis in the United States.

JAAD case reports
2026

Adaptation of custom capture sequencing panels to the Oxford Nanopore MinION platform.

Molecular biology reports
2026

Risks Associated With Undisclosed Complementary and Alternative Medicine in Clinical Practice.

Mayo Clinic proceedings
2026

The lp17 regulatory elements in Borrelia burgdorferi: a novel small RNA impacts gene expression and mammalian infection.

mBio
2026

Enterococcal Endocarditis in a Bicuspid Aortic Valve Associated With a Sinus of Valsalva Aneurysm.

Cureus
2026

Assessment of lipid mediators in the urine of patients with Lyme disease, tick-borne encephalitis and human granulocytic anaplasmosis.

Scientific reports
2026

Distribution of Borrelia burgdorferi sensu lato in micromammals in the Republic of Korea.

Acta tropica
2026

Making the best of a sticky situation: Infection-mediated endothelial activation promotes new interactions with adhesins of the host-adapted Lyme disease spirochete.

bioRxiv : the preprint server for biology
2026

Bilateral Facial Palsy and Epstein-Barr Infection in Children: A Case Report and Literature Review.

Viruses
2026

Prevalence and Risk Factors of Borrelia burgdorferi Sensu Lato IgG Antibodies Among Blood Donors in Western Romania.

Pathogens (Basel, Switzerland)
2026

Advanced Molecular and Microscopic Diagnostics Suggest Congenital Borrelia Transmission: A Case Report.

Microorganisms
2026

Tick-Borne Co-Infection in Lyme Disease: Clinical Impact, Diagnostic Challenges, and Therapeutic Perspectives.

Microorganisms
2026

The Lyme Disease Vaccine Paradox.

Journal of clinical medicine
2026

A Case of Jarisch-Herxheimer Reaction After Ceftriaxone Initiation for Lyme Carditis in Postpartum Female.

Case reports in infectious diseases
2026

Pilot study of psilocybin in patients with post-treatment lyme disease.

Scientific reports
2026

Immune interactions of entomopathogens with mosquito and tick vectors.

Trends in parasitology
2026

Biosensor for Lyme Disease: Real-time, Specific, and Label-Free Complementary Metal-Oxide-Silicon Transistor Sensing of Borrelia burgdorferi s.l. Outer Surface Protein A in Unprocessed Blood.

ACS sensors
2026

EXPRESS: A Comprehensive Review of Lyme disease in Latin America.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research
2026

Single-cell immunophenotyping identifies CD8+GZMK+IFNG+ T cells as a key immune population in cutaneous Lyme disease.

JCI insight
2026

Multiplexed single-tier immunoassay for improved Lyme disease diagnosis across all disease stages.

Research square
2026

Type I interferon signaling promotes early innate control of Borrelia burgdorferi infection.

bioRxiv : the preprint server for biology
2026

Post-Exposure Prophylaxis Prescribing Practices in a Lyme Disease-Endemic Area.

Infectious disease reports
2026

The Use of Apitherapy in Oncological Exotic Pet Medicine.

The veterinary clinics of North America. Exotic animal practice
2026

Non-invasive ovulation tracking enables genetic engineering in wild rodents.

Cell reports methods
2026

Probable Lyme carditis in pacemaker candidates with atrioventricular block: Preliminary results from northern Serbia.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2026

Clinical data on symptomatic cutaneous reinfections due to Borrelia burgdorferi sensu lato in Slovenia.

Infection
2026

Strain-specific immune response patterns to Borrelia burgdorferi infection: a comparative transcriptomic analysis in C3H and C57BL/6 mice.

Infection and immunity
2026

Interaction dynamics of borrelia surface proteins with fibronectin.

Biointerphases
2026

Exploring Cerebrovascular Manifestations of Neuroborreliosis: A Scoping Review.

Annals of Indian Academy of Neurology
2026

Citizen Science Tick Observations Serve as an Early Warning System for Tick-Borne Diseases.

Zoonoses and public health
2026

Survey of tick control practices on public lands across 4 states reporting high incidence of Lyme disease.

Journal of medical entomology
2026

Seroprevalence and seroconversion of Lyme borreliosis among tick-bitten individuals: A multi-assay serosurveillance study.

Ticks and tick-borne diseases
2026

Lyme in the prosthetic joint: two cases and a review of the literature.

Journal of bone and joint infection
2026

The influence of Borrelia burgdorferi and Anaplasma phagocytophilum bacteria on phospholipid metabolism in the blood of patients.

Biomedicine &amp; pharmacotherapy = Biomedecine &amp; pharmacotherapie
2026

Core-sheath coupling controls flagellar curvature and motility in Leptospira.

bioRxiv : the preprint server for biology
2026

Tick-borne rash at the surgical site prior to lung cancer resection: a diagnostic and surgical dilemma case report.

AME case reports
2026

Case series of acrodermatitis chronica atrophicans in the United States with absent or remote European travel.

JAAD case reports
2026

Uncommon Neuro-Ophthalmologic Findings in Pediatric Lyme Disease.

Cureus
2026

Emerging risk of tick-borne diseases in South Korea: Lyme disease, anaplasmosis, and babesiosis.

Clinical and experimental vaccine research
2026

Borrelia mayonii induces carditis but not arthritis in Lyme-susceptible mice.

Frontiers in immunology
2026

Structure and ligand specificity of Borrelia burgdorferi BmpA.

bioRxiv : the preprint server for biology
2026

Chronic Tonsillitis as a Focal Infection: A Decade-Long Case Involving Severe Systemic Symptoms.

Cureus
2026

Sex and menopause-based differences in presentation of early Lyme disease: A prospective cohort study.

Clinical and experimental medicine
2026

Telomere-to-telomere assembly detects genomic diversity in Canadian strains of Borrelia burgdorferi.

Cell reports
2026

Streamlining Borrelia burgdorferi cultivation using quantitative PCR screening.

Journal of medical microbiology
2026

Distinct Clinico-pathogenic Subgroups in Pediatric Lyme Neuroborreliosis.

Open forum infectious diseases
2026

A Lyme Neuroborreliosis Case Presenting With Ophthalmoplegia, Dysarthria, and Spastic Quadriparesis.

Cureus
2026

Geographic variation in risk of blacklegged tick-borne coinfections in the eastern United States.

Ticks and tick-borne diseases
2026

Interacting effects of mean temperature and temperature variability on Ixodes scapularis (Acari: Ixodidae) overwinter survival and energy use.

Journal of medical entomology
2026

Protective properties of a candidate C-terminal domain OspA vaccine for prevention of Lyme disease.

Vaccine
2026

Lyme disease forecasting in the U.S. Department of Defense: summary of one- to three-month forecasts, January-October 2024.

MSMR
2026

Retrospective Case Series of Ocular Lyme Disease, 1988-2025.

Emerging infectious diseases
2026

Serological evidence of tick-borne encephalitis virus in limousin, france.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2026

Automated Enrichment of DNA Biomarkers from Large-Volume Samples: Detection of B. burgdorferi Cell-Free DNA in Urine.

Analytical chemistry
2026

The Erosion of a Pillar of Public Health: ACIP's Role and the Future of U.S. Vaccine Policy Post-June 2025.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2025

Beyond Bell's: A Case Study of Bilateral Facial Paralysis From Lyme Neuroborreliosis.

Cureus
2026

A lethal combination: fulminant liver failure due to Babesia microti and Borrelia burgdorferi co-infection.

Therapeutic advances in infectious disease
2026

Molecular Detection of Theileria equi, Babesia caballi, and Borrelia burgdorferi Sensu Lato in Hippobosca equina from Horses in Spain.

Pathogens (Basel, Switzerland)
2026

Ectoparasite- and Vector-Borne-Related Dermatoses: A Single-Centre Study with Practical Diagnostic and Management Insights in a One Health Perspective.

Journal of clinical medicine
2026

Lyme Carditis Identified by a Novel Syndromic Surveillance Definition, New York State, 2017-2021.

Public health reports (Washington, D.C. : 1974)
2026

Transcriptomic response to Borrelia afzelii infection in the skin of wild bank voles.

Microbiology spectrum
2026

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2026

Long-Term Cardiac Sequelae in Lyme Carditis: A Review.

Current cardiology reviews
2025

Nonspecific Symptoms Attributable to Lyme Disease in High-Incidence Areas, United States, 2017-2021.

Emerging infectious diseases
2026

Borrelia burgdorferi-Induced Neuroinflammation in Lyme Disease: A Potential Driver of Alzheimer's Disease Pathology?

Molecular neurobiology
2026

Xenodiagnosis to search for Borrelia burgdorferi after antibiotic treatment of Lyme disease: a prospective cohort study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2026

Borrelia Infections Under B Cell-Depleting Therapies: A Systematic Review of Diagnostic Challenges and Outcomes With Special Focus on Neurological Forms.

European journal of neurology
2026

Peptidoglycan architecture dictates protein interactions, tissue tropism, and arthritis in the Lyme disease spirochete Borrelia burgdorferi.

PLoS pathogens
2026

Gut microbiota landscape of Haemaphysalis longicornis under Borrelia burgdorferi infection.

Insect science
2026

Using participatory epidemiology to understand differences in tick-borne disease perceptions from homeowners in the Ohio River valley.

One health (Amsterdam, Netherlands)
2026

The niche of Borrelia burgdorferi sensu lato in Europe is predictable and mappable.

One health (Amsterdam, Netherlands)
2025

Seropositive Myasthenia Gravis Triggered by Lyme Disease: A Case Study of Molecular Mimicry.

Cureus
2026

Skin Tone Representation of Early Lyme Disease in Medical Education Resources: Gaps and Implications for Equity.

Journal of medical education and curricular development
2026

Borrelia burgdorferi s.l. and its genetic variability in five European countries.

Ticks and tick-borne diseases
2026

Ocular findings in patients with lyme disease: a systematic review and meta-analysis.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
2026

Develop a durable, memory-driven, CspZ-targeting Lyme disease vaccine by rationale adjuvant selection.

bioRxiv : the preprint server for biology
2026

Late Lyme neuroborreliosis presenting with tremor and gait impairment.

Practical neurology
2026

Lyme Disease and Health Care Costs.

JAMA network open
2026

Running into the Lyme-light: a retrospective cross-sectional study of tick bites and Lyme disease prevalence, incidence, and prevention in hill runners, Scotland, UK.

BMC public health
2026

Comparative genomics of Borrelia lusitaniae.

G3 (Bethesda, Md.)
2025

Discrimination of Hard Ticks by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP).

International journal of molecular sciences
2026

Lyme Disease: More Than a Bullseye Rash.

Advanced emergency nursing journal
2026

Unravelling the genomic landscape of Canadian Borrelia burgdorferi: a comparison across global strains.

Microbial genomics
2026

Doxycycline-Induced Gastrointestinal Injury for Potential Lyme Disease Exposure.

ACG case reports journal
2025

A Unique Case of Squamous Cell Carcinoma on the Palm in a Patient with Lyme Disease.

The Journal of clinical and aesthetic dermatology
2026

Mapping ticks (Acari: Argasidae, Ixodidae) and informing local public action: Insights from the United Kingdom Tick Surveillance Scheme (2021-2024).

Ticks and tick-borne diseases
2026

Invasive wineberry influences tick-borne disease dynamics across spatial scales.

Ticks and tick-borne diseases
2026

Disentangling complex disease ecology networks: Using structural equation modelling to quantify the direct and indirect effects of deer on Lyme borreliosis hazard.

Ticks and tick-borne diseases
2026

Biting back at Lyme disease.

Nature medicine
2025

Isolated Optic Neuritis Revealing Lyme Disease in an Adolescent: A Case Report and Literature Review.

Cureus
2026

Lyme disease as a rare trigger for autoimmune hemolytic anemia.

BMC infectious diseases
2026

The repetitive genome of the Ixodes ricinus tick reveals transposable elements have driven genome evolution in ticks.

Genome biology
2026

Targeting of interaction between BB0323-BB0238 informs new paradigms in Lyme disease therapeutics.

PLoS pathogens
2025

Optic disc edema associated with neuroborreliosis.

IDCases
2025

Interlaboratory Concordance of a Multiplex ELISA for Lyme and Lyme-like Illness Using Australian Samples and Commercial Reference Panels: A Proof-of-Concept Study.

Pathogens (Basel, Switzerland)
2025

Prevalence of Borrelia afzelii and Borrelia garinii Genospecies in Ixodes ricinus Ticks Collected from Three Regions in Bulgaria.

Pathogens (Basel, Switzerland)
2025

Prevalence of Borreliaceae Spirochetes in Ticks Removed from Humans in Poland During 2018-2022.

Pathogens (Basel, Switzerland)
2025

The First Study of Borrelia burgdorferi Sensu Lato Persistence in Small Mammals Captured in the Ixodes persulcatus Distribution Area in Western Siberia.

Pathogens (Basel, Switzerland)
2025

Basophilic Response in Patients with Persistent Symptoms Attributed to Lyme Borreliosis Treated with Hydrolysed Arabinoxylan Rice Bran.

Medicina (Kaunas, Lithuania)
2025

Lipid scavenging by the Lyme disease spirochete Borrelia burgdorferi.

PLoS pathogens
2025

Deficiencies in communication between clinical microbiological laboratories and physicians may impair the diagnosis of Lyme borreliosis: A study of the use and application of serology in three neighbouring counties in Sweden.

PloS one
2025

Guidance on the management of asymptomatic blood donors who test positive for Babesia.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2025

Early brain changes in Lyme disease are associated with clinical outcomes.

Brain, behavior, &amp; immunity - health
2025

Whole Genome Characterization of Borrelia bavariensis Strain KW3 Isolated from Ixodes Granulatus in South Korea.

Vector borne and zoonotic diseases (Larchmont, N.Y.)
2025

Metabolomics-Based Machine Learning Diagnostics of Post-Acute Sequelae of SARS-CoV-2 Infection.

Metabolites
2025

Skin ulcer and maculopapular rash with inguinal lymph node enlargement: a case report of a 46-year-old female patient from north-eastern Poland with Rickettsia spp. and Francisella tularensis co-infection.

Central-European journal of immunology
2025

Dissection of amino acid acquisition pathways demonstrates that amino acid starvation of Borrelia burgdorferi results in a (p)ppGpp-independent maladaptive response.

Communications biology
2025

Autonomic Symptoms in Post-Treatment Lyme Disease: Insights From the COMPASS-31 and the 10-Minute Active Stand Test.

Mayo Clinic proceedings. Innovations, quality &amp; outcomes
2026

A human Lyme disease vaccine: two steps forward on the path to prevention.

Expert review of vaccines
2025

Methemoglobinemia induced by dapsone, hydroxychloroquine, and rifampin combination for post-treatment Lyme disease syndrome: A case report.

Journal of the American Pharmacists Association : JAPhA
2026

Rising seroprevalence of Borrelia spp. in free roaming felines in the eastern Tennessee valley.

Veterinary parasitology
2025

[Lyme carditis : an unusual approach to temporary pacing].

Revue medicale suisse
2025

Peripheral Facial Paralysis as a Sentinel Symptom of Early Lyme Neuroborreliosis: A Diagnostic Challenge.

Cureus
2025

Impact of climate change and infectious diseases: Implications for healthcare providers in the UK.

Future healthcare journal
2025

Parasitiformes (ticks) and Acariformes (mites) vectors and their vertebrate host diversity: A global scoping review.

One health (Amsterdam, Netherlands)
2025

Lyme disease control 2.0: Advances and opportunities coming with Lyme disease vaccine VLA15.

PLoS pathogens
2025

Lyme Disease: An Emerging Threat.

The Journal of the Association of Physicians of India
2026

Lyme arthritis: Demographic characteristics and Borrelia ospA genospecies in synovial fluid. A 17-year cohort study in Sweden.

Ticks and tick-borne diseases
2026

Synergistic Lyme Carditis and Coxsackievirus A Myocarditis Presenting With Fulminant Heart Failure.

JACC. Case reports
2025

Borrelia afzelii Hepatitis in Patient Treated with Venetoclax and Obinutuzumab, Switzerland.

Emerging infectious diseases
2025

Seroprevalence of selected vector-borne agents in pet cats using the SNAP® 4Dx® PLUS, United States, 2022-2025.

Veterinary parasitology, regional studies and reports
2025

Efficacy of Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) and Credelio™ (lotilaner) chewable tablets in the prevention of Borrelia burgdorferi transmission from infected Ixodes scapularis in dogs.

Parasites &amp; vectors
2026

The lingering shadow of epidemics: post-acute sequelae across history.

Trends in immunology
2025

Lyme Disease Incidence in Massachusetts, 2012-2024.

JAMA network open
2025

Polyvalent mRNA vaccine targeting outer surface protein C affords multi-strain protection against Lyme disease.

NPJ vaccines
2025

Beyond the bite: Sensorineural hearing loss as a rare manifestation of lyme disease.

Acta otorrinolaringologica espanola
2025

Bilateral Granulomatous Keratic Precipitates Following Inadequate Antibiotic Coverage for Presumed Lyme Disease.

Cureus
2025

Think Outside the Lyme Box: Optic Neuropathy and Polyarthritis Caused by Borrelia miyamotoi.

Cureus
2025

[Surveillance of Tick Distribution and Infection Rate of Tick-borne Infectious Diseases in Gyeongsangbuk-do Province and Daegu Metropolitan City in 2024].

Jugan geon-gang gwa jilbyeong
2025

Toll-like receptor 1 polymorphism is associated with impaired immune tolerance, dysregulated inflammatory responses to Borrelia burgdorferi, and heightened risk of post-infectious Lyme arthritis.

Frontiers in immunology
2026

Increased Borrelia burgdorferi Seroprevalence in Nova Scotia-Prevalence and Distribution 10 Years Later.

Zoonoses and public health
2025

Lyme borreliosis incidence in relation to mammalian abundance, climate, and landscape characteristics in a boreal area.

Parasites &amp; vectors
2026

Tick-Borne Diseases in Urban and Periurban Areas: A Blind Spot in Research and Public Health.

Annual review of entomology
2025

Polymerase Chain Reaction-Confirmed Lyme Neuroborreliosis Masked by Pseudomonas Mastoiditis in a Mexican Traveler: A Case Report.

Cureus
2025

Guidelines for Lyme borreliosis: clinical manifestations.

Infectious diseases now
2025

Incidence of Lyme borreliosis following Ixodes ricinus tick bites in Poland: a citizen science approach.

Parasites &amp; vectors
2025

Human epidermal Langerhans cells induce tolerance and hamper T cell function upon tick-borne pathogen transmission.

Nature communications
2025

Guidelines for Lyme borreliosis: post-treatment Lyme disease syndrome (PTLDS).

Infectious diseases now
2025

Guidelines for tick-borne diseases (excluding Lyme borreliosis): diagnosis and management.

Infectious diseases now
2025

Guidelines for Lyme borreliosis: treatment.

Infectious diseases now
2025

Guidelines for Lyme borreliosis: Diagnostic strategies.

Infectious diseases now
2025

Serologies in Lyme disease can be deceiving: a rare case of mycoplasma-induced figurate erythema with persistent IgM Lyme antibodies.

Oxford medical case reports
2025

Prevalence and clinical characteristics of Norwegians who report persistent health complaints attributed to tick bites or tick-borne diseases.

BMC infectious diseases
2025

Genomic characterization of clinical Borrelia burgdorferi sensu lato isolates in the Netherlands over a thirty-year period.

BMC genomics
2025

Impact of community pharmacist antibiotic prescribing for minor ailments: an interrupted time series analysis.

BMJ open
2025

The Relationship Between Hemodynamic Responses During Head-Up Tilt Testing and Parameters of Infection in Post-COVID Syndrome, Chronic Fatigue Syndrome, and Late-Stage Lyme Disease.

Viruses
2025

Comparative Genomics of Two Newly Sequenced Rodent-Derived and One Previously Reported Tick-Derived Borrelia garinii Strains from South Korea Reveals Plasmid Variation and Virulence Gene Diversity.

Pathogens (Basel, Switzerland)
2025

Borreliosis and Other Tick-Borne Diseases in the Northern and Southern Hemispheres.

Microorganisms
2025

Evaluation of Immune Response Dynamics: Analyzing the Parameters of Complete Blood Count (CBC) in Experimental Borreliosis.

Life (Basel, Switzerland)
2025

Evaluating Outer Membrane Vesicle Isolation Techniques for Borrelia burgdorferi and Their Impact on Vesicle Composition, Gene Expression Profile and Uptake.

Antibiotics (Basel, Switzerland)
2025

RNAi-Based Bioinsecticides for Controlling Vector-Borne Diseases.

Genes
2026

Synovial chemokine and cytokine profiles in horses with and without systemic Borrelia burgdorferi infection.

Equine veterinary journal
2025

Climate-Driven Immune Gene Expression Profiles in Peromyscus leucopus: Implications for Bacterial Infection Dynamics.

Ecological and evolutionary physiology
2025

Characteristic Optical Coherence Tomography and Magnetic Resonance Imaging Findings in a Case of Seronegative Neuroretinitis.

Cureus
2025

Investigating the frequency of tick-borne infections in a case series of 37 youth diagnosed with pediatric bipolar disorder.

Frontiers in child and adolescent psychiatry
2025

Quantifying the Public Health Impact of Lyme Disease in Minnesota: A Simulation Analysis of Reported and Unreported Cases.

Journal of health economics and outcomes research
2025

Genetic landscape of Borrelia burgdorferi sensu stricto in Canada: a study of genetic diversity.

Scientific reports
2025

Dermal fibroblast cultures recapitulate differences between deermice and mice in their responses to a Toll-like receptor agonist.

Frontiers in immunology
2025

Relative Bradycardia in a 61-Year-Old Male With Anaplasmosis: A Case Report.

Cureus
2026

First evidence of human borreliosis local transmission in Cambodia.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2025

Seroprevalence of Borrelia burgdorferi sensu lato and incidence of Lyme borreliosis in Switzerland.

Ticks and tick-borne diseases
2026

Pathogen and host associations of Ixodes scapularis (Acari: Ixodidae) in eastern Ohio 10 years post establishment.

Journal of medical entomology
2025

Line-field confocal optical coherence tomography in vivo description of Ixodida (tick).

Journal of the European Academy of Dermatology and Venereology : JEADV
2026

Home Testing for Contagious Illness: Historical Context and Modern Caveats.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2025

Rabies virus-vectored Lyme disease vaccine provides long-term protection against tick-transmitted Borrelia burgdorferi.

NPJ vaccines
2025

EPR spectroscopy reveals antioxidant manganese defenses in the Lyme disease pathogen Borrelia burgdorferi.

mBio
2026

Exploring Genetic Engineering Through a Deliberation in Biochemistry.

Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology
2025

Global trends in tick research: a comprehensive visualization and bibliometric study (2015-2024).

Frontiers in cellular and infection microbiology
2025

Silent Spread of Borrelia Infection in Sardinia, Italy: Implications for Integrated Surveillance in the Mediterranean.

Healthcare (Basel, Switzerland)
2025

Antibiotics for Rheumatologic Diseases: A Critical Review.

International journal of molecular sciences
2025

Atypical presentation of Lyme disease in a returning traveler: a case report.

Tropical diseases, travel medicine and vaccines
2025

Risk Factors for Lyme Disease in the General Population-A Survey of Adults and Caregivers in 28 States.

Open forum infectious diseases
2026

Immunogenicity and safety of an 18-month booster dose of the VLA15 Lyme borreliosis vaccine candidate after primary immunisation in children, adolescents, and adults in the USA: a randomised, observer-blind, placebo-controlled, phase 2 trial.

The Lancet. Infectious diseases
2026

A CRISPR/LbCas12a system for Borrelia burgdorferi sensu stricto detection in blacklegged ticks.

Journal of medical entomology
2025

[Isolated Sixth Cranial Nerve Palsy as a Clinical Presentation of Neuroborreliosis].

Revista de neurologia
2026

Registered Nurses' Knowledge, Attitudes, and Practices Toward Climate-Sensitive Vector-Borne Diseases: Findings From a Cross-Sectional Survey.

Public health nursing (Boston, Mass.)
2025

Rapid Northward Expansion of the Blacklegged Tick, Ixodes scapularis, in Response to Climate Change.

Global change biology
2025

Cutaneous Lyme borreliosis: Guideline of the German Dermatology Society.

German medical science : GMS e-journal
Ver todos os 5.850 no EuropePMC

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. An Fc-silent OspA monoclonal antibody passively protects mice from tick and intradermal Borrelia burgdorferi challenge.
    PloS one· 2026· PMID 41818320mais citado
  2. Feasibility of an adjunctive INtervention for Debilitating symptom complexes attributed to ticks (FIND): study protocol for a randomised, waitlist-controlled feasibility trial.
    BMJ open· 2026· PMID 41807010mais citado
  3. Non-invasive ovulation tracking enables genetic engineering in wild rodents.
    Cell reports methods· 2026· PMID 41709464mais citado
  4. Exploring Cerebrovascular Manifestations of Neuroborreliosis: A Scoping Review.
    Annals of Indian Academy of Neurology· 2026· PMID 41700589mais citado
  5. Telomere-to-telomere assembly detects genomic diversity in Canadian strains of Borrelia burgdorferi.
    Cell reports· 2026· PMID 41649924mais citado
  6. Severe Babesiosis With Lyme Disease and Anaplasma Phagocytophilum Coinfection in a Dialysis-Dependent Patient Without Rash or Organomegaly.
    Cureus· 2026· PMID 41994764recente
  7. A MinD-like ATPase couples flagellation and cell division in spirochetes.
    bioRxiv· 2026· PMID 41993557recente
  8. From forest floor to doctor's office: the immunological journey of Borrelia burgdorferi through vertebrate hosts.
    Front Immunol· 2026· PMID 41988178recente
  9. Differentiating Clinical Presentations of Lyme Arthritis, Septic Arthritis, Toxic Synovitis, and Other Inflammatory Joint Pathologies.
    J Pediatr Orthop· 2026· PMID 41983573recente
  10. Autoimmune Epilepsy Temporally Associated With Lyme Disease: A Report of Two Cases.
    Cureus· 2026· PMID 41982592recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:91546(Orphanet)
  2. MONDO:0019632(MONDO)
  3. Busca completa no PubMed(PubMed)
  4. Artigo Wikipedia(Wikipedia)
  5. Q201989(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Doença de Lyme
Compêndio · Raras BR

Doença de Lyme

ORPHA:91546 · MONDO:0019632
Prevalência
Unknown
Herança
Not applicable
CID-10
A69.2 · Doença de Lyme
CID-11
Ensaios
22 ativos
Início
All ages
Prevalência
0.0 (Europe)
MedGen
UMLS
C0024198
Repurposing
1 candidato
oxytetracyclinebacterial 30S ribosomal subunit inhibitor
EuropePMC
Wikidata
Wikipedia
Papers 10a
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