É uma inflamação crônica e generalizada que afeta os dois olhos (bilateral), em todas as suas camadas (panuveíte), e é caracterizada por granulomas (pequenas aglomerações de células inflamatórias). Normalmente, essa inflamação causa o descolamento da retina (quando ela se solta) devido ao acúmulo de líquido. E, frequentemente, está associada a alterações neurológicas (como a meningite, uma inflamação que atinge o cérebro), problemas de audição e mudanças na pele.
Introdução
O que você precisa saber de cara
É uma inflamação crônica e generalizada que afeta os dois olhos (bilateral), em todas as suas camadas (panuveíte), e é caracterizada por granulomas (pequenas aglomerações de células inflamatórias). Normalmente, essa inflamação causa o descolamento da retina (quando ela se solta) devido ao acúmulo de líquido. E, frequentemente, está associada a alterações neurológicas (como a meningite, uma inflamação que atinge o cérebro), problemas de audição e mudanças na pele.
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 16 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 39 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
3 genes identificados com associação a esta condição. Padrão de herança: Multigenic/multifactorial.
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in v
Cell membraneMembrane raftSecreted
Autoimmune lymphoproliferative syndrome 1A
A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia.
Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system a
Cytoplasm
Systemic lupus erythematosus
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB1-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells
Cell membraneEndoplasmic reticulum membraneLysosome membraneLate endosome membraneAutolysosome membrane
Medicamentos e terapias
Mecanismo: Vascular endothelial growth factor A inhibitor
Mecanismo: Glucocorticoid receptor agonist
Variantes genéticas (ClinVar)
530 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
14 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Doença de Vogt-Koyanagi-Harada
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
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Outros ensaios clínicos
15 ensaios clínicos encontrados, 1 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 698
Evaluation of Melanin Changes in Acute Vogt-Koyanagi-Harada Disease Using Polarization-Sensitive Optical Coherence Tomography.
To examine melanin changes in the RPE and choroid during the acute phase of Vogt-Koyanagi-Harada (VKH) disease using polarization-sensitive optical coherence tomography (PS-OCT). This study included 15 eyes of 8 patients with new-onset VKH disease and 5 eyes of 3 patients with posterior scleritis. PS-OCT captured a 12 × 12 mm area centered on the fovea, and en face images were created for the RPE and choroid. Polarimetric entropy within a 6-mm diameter circle centered on the fovea was calculated and compared between groups. Choroidal polarimetric entropy was significantly lower in eyes with VKH disease than in those with posterior scleritis at baseline (0.296 ± 0.047 vs. 0.392 ± 0.050; P = 0.005; r = 0.64; 95% confidence interval, 0.42-0.74). One month after starting treatment, eyes with VKH disease showed a significant increase in choroidal polarimetric entropy (0.296 ± 0.047 to 0.350 ± 0.075; P = 0.001; r = 0.85; 95% confidence interval, 0.61-0.95), whereas no significant change was observed in eyes with posterior scleritis. RPE polarimetric entropy showed no significant changes between baseline and 1 month, with no differences between groups. PS-OCT revealed that choroidal melanin density decreased during the acute phase of VKH disease and significantly increased after treatment. PS-OCT provides a noninvasive method for observing melanin dynamics in VKH disease and aids in differentiating it from posterior scleritis. PS-OCT could offer valuable insights into the pathology of VKH disease and its potential implications for management.
Natural experiment on neuroinflammatory disease incidence and infection links pre- and post-COVID-19.
Infections are recognized triggers for several neuroinflammatory disorders. The coronavirus disease 2019 (COVID-19) pandemic's non-pharmaceutical interventions sharply curtailed pathogen exposure, creating a natural experiment to test infection-disease links. Using Japan's National Claims Database, we first validated the nationwide decline with two strictly infection-dependent conditions-epidemic keratoconjunctivitis and influenza-associated encephalopathy-whose monthly incidences fell by >60% after April 2020. Next, we applied an interrupted time series design, a causal-inference method for longitudinal data, to nine immune-mediated inflammatory diseases. Unsupervised clustering of model-derived level and slope changes identified three data-driven clusters. The first cluster, comprising Guillain-Barré syndrome and acute disseminated encephalomyelitis, showed large, statistically significant level reductions (P < 0.001), particularly in women, consistent with infection-susceptible pathophysiology. The second cluster, including myasthenia gravis and optic neuritis, exhibited transient declines followed by significant positive post-intervention slopes (P < 0.001), suggesting deferred diagnosis, treatment interruption or immune rebound. The third cluster, consisting of sarcoidosis, neuromyelitis optica, multiple sclerosis, Vogt-Koyanagi-Harada disease and Behçet's disease, remained stable, suggesting limited or complex infectious links. These data-driven trajectories mirror clinical pathophysiology and demonstrate that reduced pathogen exposure affects neuroinflammatory disease onset to varying degrees. This framework supports infection-related risk stratification, preventive strategies and continuity planning in neuroimmunology practice.
Seasonal Variations of Vogt-Koyanagi-Harada Disease in Japan: A Study on Long-Term Trends and the Influence of Coronavirus Disease 2019 (COVID-19).
To investigate seasonal trends in the onset of Vogt-Koyanagi-Harada (VKH) disease in Japan and evaluate the influence of the coronavirus disease 2019 (COVID-19) pandemic, including severe cases and vaccination campaigns, on disease onset. A retrospective cohort study using clinical records and public health data. A total of 320 Japanese VKH patients with a known month of onset who were initially treated at Yokohama City University Hospital between April 2007 and March 2024. The monthly distribution of VKH onset cases was assessed using the Roger test to determine seasonality before and after the COVID-19 pandemic. Severe COVID-19 case data (April 2020 to March 2024) were obtained from government sources. The COVID-19 vaccine administration data (April 2021 to March 2024) were collected from a major local clinic. Multiple linear regression was used to evaluate the temporal relationship between VKH onset and severe COVID-19 cases or vaccination, incorporating current-month (lag0), 1-month lag (lag1), and 2-month lag (lag2) predictors. Monthly number of VKH onset cases, seasonal trends, and statistical associations with COVID-19-related variables. Seasonal variation was significant in VKH onset both before (P = 0.02) and after (P < 0.001) the pandemic, with a shift in peak onset from spring to late summer/fall. Vogt-Koyanagi-Harada onset was significantly associated with severe COVID-19 cases in the current month (β = 0.097; P = 0.02) and with COVID-19 vaccination counts with a 1-month delay (β = 0.83; P = 0.002). The regression models showed moderate to strong explanatory power (adjusted R 2 = 0.52 and 0.80, respectively). This study revealed a postpandemic shift in the seasonal distribution of VKH onset in Japan, with peaks aligning with increased severe COVID-19 infections in the current month and vaccination activity in the preceding month. The findings suggest that both acute viral immune responses and delayed vaccine-induced immunity may contribute to VKH onset, highlighting the need for further investigation into the immunological mechanisms linking COVID-19 and autoimmune disease expression. The authors have no proprietary or commercial interest in any materials discussed in this article.
Choroidal Osteoma with Focal Choroidal Excavation Masquerading as Active Vogt-Koyanagi-Harada: A Case Report.
Choroidal osteoma is a rare, benign ossifying tumor of the choroid that can present with clinical features overlapping those of inflammatory choroidal lesions. In patients with a history of Vogt-Koyanagi-Harada (VKH) disease, distinguishing between inflammatory relapse and non-inflammatory choroidal pathology can be particularly challenging. This case report highlights the diagnostic pitfalls associated with choroidal osteoma in the setting of prior VKH and underscores the importance of comprehensive multimodal imaging to ensure accurate diagnosis and appropriate management. A 39-year-old female with a 14-year history of VKH disease, who had been stable off immunosuppressive therapy since 2016, presented in early 2024 with a 7-week history of cloudy vision in the right eye. She was initially diagnosed with a recurrent posterior VKH relapse and treated with high-dose intravenous corticosteroids followed by an oral taper, resulting in symptomatic improvement. However, further multimodal imaging - including wide-field fundus photography, optical coherence tomography (OCT), fundus autofluorescence, OCT angiography, fluorescein angiography, enhanced depth imaging OCT (EDI-OCT), and B-scan ultrasonography - revealed a yellow-orange, minimally elevated subretinal lesion associated with focal choroidal excavation. These findings were consistent with choroidal osteoma and confirmed by EDI-OCT and B-scan ultrasonography. This case illustrates a rare instance of choroidal osteoma masquerading as a posterior relapse of VKH disease. It emphasizes the critical importance of differentiating inflammatory from non-inflammatory choroidal lesions in patients with a history of uveitis. Careful interpretation of multimodal imaging is essential to avoid misdiagnosis, prevent unnecessary immunosuppressive treatment, and reduce associated risks, ultimately leading to improved patient outcomes.
Incidence of Cataract Surgery and Postoperative Visual Acuity Outcomes in Patients with Vogt-Koyanagi-Harada Disease.
To determine the incidence and predictive factors of visually significant cataracts requiring cataract surgery in patients with Vogt-Koyanagi-Harada (VKH) disease and to evaluate postoperative visual acuity (VA) outcomes. Medical records of 100 patients (197 phakic eyes) diagnosed with VKH between 2010 and 2023 were reviewed. Kaplan-Meier analysis was used to estimate the cumulative incidence of cataract surgery. Longitudinal postoperative VA outcomes were analyzed using a linear mixed-effects model. Forty-one eyes from 24 patients developed visually significant cataracts requiring surgery (incidence rate, 5.4% per eye-year; 95% CI, 4.0-7.3). The cumulative incidence of cataract surgery was 27.9% at 5 years after disease onset. Age > 45 years at VKH presentation (adjusted hazard ratio [aHR] = 6.7, p = 0.001), male sex (aHR = 3.8, p = 0.007), prior glaucoma medication use (aHR = 6.3, p = 0.015), prior regional corticosteroid injection (aHR = 8.3, p = 0.015), and inactive uveitis at presentation (aHR = 22.0, p < 0.001) were associated with an increased incidence of cataract surgery. The modeled mean VA improved from 1.2 logarithm of the minimum angle of resolution (logMAR) preoperatively to 0.3 logMAR at 6 months postoperatively. Systemic immunomodulatory treatment (IMT) use (adjusted odds ratio [aOR] = 14.2, p = 0.034) and absence of prior regional corticosteroid injection (aOR = 19.3, p = 0.009) increased the likelihood of achieving a VA of ≥20/40 at 6 months postoperatively. Patients with VKH have a moderate risk of cataract surgery. Cataract surgery is associated with substantial and sustained VA improvement. More favorable outcomes were observed in eyes receiving IMT and in those without a history of regional corticosteroid injection.
Publicações recentes
Vogt-Koyanagi-Harada disease recurrence after laser treatment: A case report.
Immune-mediated cochleovestibular dysfunction: clinical spectrum from isolated inner-ear disorders to systemic autoimmune diseases and therapeutic strategies.
Vogt-Koyanagi-Harada Disease with Oral Manifestations: A Rare Case Report.
Novel application for the JAK inhibitor baricitinib in the treatment of Vogt-Koyanagi-Harada disease: a prospective cohort study.
Ultra-Widefield Indocyanine Green Angiography in Uveitis.
📚 EuropePMC881 artigos no totalmostrando 195
Choroidal Osteoma with Focal Choroidal Excavation Masquerading as Active Vogt-Koyanagi-Harada: A Case Report.
Case reports in ophthalmologyIncidence of Cataract Surgery and Postoperative Visual Acuity Outcomes in Patients with Vogt-Koyanagi-Harada Disease.
Ocular immunology and inflammationVKH-Like Syndrome in a Patient on Tofacitinib.
Journal of vitreoretinal diseasesVogt-Koyanagi-Harada Disease in Paediatric Population: Case Series and Literature Review.
Ocular immunology and inflammationVogt-Koyanagi-Harada disease under the lens: Insights from multimodal ocular imaging.
Progress in retinal and eye researchCo-occurrence of Vogt-Koyanagi-Harada disease, diabetic retinopathy, and advanced chronic kidney disease: a case report.
Frontiers in medicineChanging paediatric uveitis patterns in Italy: an eight-year experience from the Reggio Emilia Uveitis clinic.
International ophthalmologyTreatment Initiation within the Therapeutic Window of Opportunity in Acute Uveitic Phase of Vogt-Koyanagi-Harada Disease Preserves Photoreceptor Function.
Ocular immunology and inflammationMethodological Limitations in Prognostic Modelling for Refractory Vogt-Koyanagi-Harada Disease: Response.
Clinical & experimental ophthalmologyFull-field electroretinogram (ffERG) over 48 months correlates with baseline retinal dysfunction in Vogt-Koyanagi-Harada disease: a longitudinal study.
Documenta ophthalmologica. Advances in ophthalmologyRetinal structure and function recovery over five years in Vogt-Koyanagi-Harada disease using adaptive optics and microperimetry.
Scientific reportsEvaluation of Melanin Changes in Acute Vogt-Koyanagi-Harada Disease Using Polarization-Sensitive Optical Coherence Tomography.
Investigative ophthalmology & visual scienceQuantitative Ultra-Widefield Imaging Measurement of Fundus Depigmentation in Vogt-Koyanagi-Harada Disease.
Ocular immunology and inflammationDemography, clinical features, and outcomes of Vogt-Koyanagi-Harada disease presenting with bullous exudative retinal detachment.
Indian journal of ophthalmologyOptical coherence tomography angiography features of inflammatory choroidal neovascularizaton in Vogt-Koyanagi-Harada disease.
Indian journal of ophthalmologySegmental choroidal vascularity in Acute Vogt-Koyanagi-Harada disease.
International journal of retina and vitreousMethodological Limitations in Prognostic Modelling for Refractory Vogt-Koyanagi-Harada Disease.
Clinical & experimental ophthalmologyEfficacy of Tumor Necrosis Factor-α Inhibitor Adalimumab in Chronic Recurrent Vogt-Koyanagi-Harada Disease.
Pharmaceuticals (Basel, Switzerland)Near-Infrared Autofluorescence in Non-Infectious Uveitis: A Review.
Ocular immunology and inflammationTwo cases of juxtapapillary retinal astrocytic hamartoma: a multimodal imaging study.
BMC ophthalmologyNatural experiment on neuroinflammatory disease incidence and infection links pre- and post-COVID-19.
Brain : a journal of neurologyFactors associated with the avoidance of glaucoma surgery in secondary glaucoma due to ocular inflammatory disease.
Journal of ophthalmic inflammation and infectionVogt-Koyanagi-Harada disease-like immune-related adverse event with concurrent exacerbation of uveitis and vitiligo.
European journal of dermatology : EJDHyperreflective Choroidal Foci: A Comprehensive Review.
Journal of ophthalmic & vision researchAnalysis of the Retinal Microcirculation in Chinese Patients With Vogt-Koyanagi-Harada Disease by Optical Coherence Tomography Angiography.
Translational vision science & technologyEpidemiological Characterization of Uveitis in Pediatric Population: A Systematic Review and Meta Analysis.
Ocular immunology and inflammationWeekly adalimumab: A promising approach for managing refractory non-infectious chronic pediatric uveitis.
Journal francais d'ophtalmologieSingle-cell RNA sequencing reveals beneficial mechanisms of Exendin-4 in autoimmune uveitis.
Biochemical pharmacologyDIAGNOSTIC PERFORMANCE OF MACHINE LEARNING TECHNOLOGY USING OPTICAL COHERENCE TOMOGRAPHIC IMAGE IN RETINAL DISEASES PRESENTED WITH SUBRETINAL FLUID.
Retina (Philadelphia, Pa.)Secondary Adrenal Insufficiency and Iatrogenic Cushing's Syndrome in a 13-Year-Old Male With Vogt-Koyanagi-Harada Disease: A Case Report.
Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & PractitionersEarly imaging and systemic findings in pediatric Vogt-Koyanagi-Harada disease.
Journal francais d'ophtalmologieSecondary Choroidal Osteoma in the Setting of Uveal Pathology: 4 Case Reports and Review.
Ocular oncology and pathologySeasonal Variations of Vogt-Koyanagi-Harada Disease in Japan: A Study on Long-Term Trends and the Influence of Coronavirus Disease 2019 (COVID-19).
Ophthalmology scienceDiagnostic and Management Challenges in Atypical Central Serous Chorioretinopathy Mimicking Vogt-Koyanagi-Harada Disease: A Case Report.
CureusClinical characteristics and long-term outcomes of Vogt-Koyanagi-Harada disease in pediatric age group.
BMC ophthalmologyInfluenza-Associated Ocular Complications: A Comprehensive Review of Viral Subtypes, Clinical Presentations, and Vaccination Risks.
VaccinesSafety and efficacy of rituximab in refractory noninfectious uveitis and scleritis.
Journal of ophthalmic inflammation and infectionAn Eye for an Eye, An Ear for an Ear: A Midwestern Case Report of Vogt-Koyanagi-Harada Disease.
WMJ : official publication of the State Medical Society of WisconsinDynamics of color vision recovery in Vogt-Koyanagi-Harada disease: a longitudinal study using cone contrast test and adaptive optics imaging.
Journal of ophthalmic inflammation and infectionUltrawidefield Optical Coherence Tomography Angiography in the Mid-Periphery and Macula of Vogt-Koyanagi-Harada Disease.
Ocular immunology and inflammationClinical characteristics and visual outcome of Vogt Koyanagi Harada disease patients in a specialized eye hospital in Nepal.
Journal of Nepal Health Research CouncilIn the Race Against Time to Treat Vogt-Koyanagi-Harada Disease.
Clinical & experimental ophthalmologyEpidemiology and Clinical Features of Uveitis in Southwestern Japan: Laterality and Long-Term Visual Prognosis Based on the Anatomical and Epidemiological Classification.
Ocular immunology and inflammationClinical features, treatment and outcomes of dabrafenib-associated uveitis.
Investigational new drugsUse of Imaging Modalities in Vogt-Koyanagi-Harada Disease: An Overview.
Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnostiVogt-Koyanagi-Harada Disease in which Poliosis and Alopecia Occurred after a Long Period of Time.
Acta dermatovenerologica Croatica : ADCPredictive factors at initial visit for sunset glow fundus in Vogt-Koyanagi-Harada disease.
Scientific reportsAcute interstitial nephritis and probable Vogt-Koyanagi-Harada disease following COVID-19 infection: a case report.
Journal of medical case reportsPrevalence and clinical characteristics of ocular sarcoidosis among non-infectious uveitis in a Chinese tertiary ophthalmic center: a retrospective observational study.
BMC ophthalmologyRetrospective analysis of Vogt-Koyanagi-Harada's recurrence within a case series of nineteen patients followed between 2003 and 2018 in an academic center.
Journal of ophthalmic inflammation and infectionRevising the role of cerebrospinal fluid pleocytosis as a diagnostic criterion in Vogt-Koyanagi-Harada disease.
Eye (London, England)Alterations of the Enteric Virome in Vogt-Koyanagi-Harada Disease.
Investigative ophthalmology & visual scienceTonic Pupils in a Young Female with Vogt Koyanagi Harada Disease.
Klinische Monatsblatter fur AugenheilkundeVogt Koyanagi Harada disease with bilateral disc edema diagnosed as Arnold Chiari malformation with papilledema: The blurred margin between ophthalmology and neurology.
Indian journal of ophthalmologyComparative study of efficacy and safety of pulse versus half-pulse steroid therapy for Vogt-Koyanagi-Harada Disease.
Japanese journal of ophthalmologyOptical Coherence Tomography Biomarkers in Acute Vogt-Koyanagi-Harada Disease: Clinical Significance of Hyperreflective Outer Nuclear Layer and Bacillary Layer Detachment.
Ocular immunology and inflammationNon-infectious uveitis: a multicenter study from Argentina.
International ophthalmologyLong-Term Outcomes of Pediatric Vogt-Koyanagi-Harada Disease.
Ocular immunology and inflammationClinical Characteristics, Recurrences, and Complications in the Mexican Pediatric Patients with Vogt-Koyanagi-Harada Disease.
Ocular immunology and inflammationBacillary layer detachment in acute Vogt-Koyanagi-Harada disease: an early predictor of long-term complications in a Brazilian cohort.
International journal of retina and vitreousSafety of Mycophenolate Mofetil in the Treatment of Non-Infectious Uveitis and Sclerouveitis in Japanese Patients: A Feasibility Study.
Ocular immunology and inflammationPredictive Factors for Uveitis Refractory to Treatment in Initial-Onset Acute Vogt-Koyanagi-Harada Disease.
Clinical & experimental ophthalmologyOleic acid regulates CD4+ T cells differentiation by targeting ODC1-mediated STAT5A phosphorylation in Vogt-Koyanagi-Harada disease.
Phytomedicine : international journal of phytotherapy and phytopharmacologyEfficacy of azathioprine as a first-line therapy in new onset of acute Vogt-Koyanagi-Harada disease in the Indian population.
Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyOptical Density Analysis of Subretinal Fluid in Vogt Koyanagi Harada Disease, Posterior Scleritis and Acute Central Serous Chorioretinopathy.
Ocular immunology and inflammationOccult invasive fungal sinusitis in a patient with acute Vogt-Koyanagi-Harada Disease (VKHD).
Retinal cases & brief reportsVogt-Koyanagi-Harada disease in a patient with retinitis pigmentosa in one eye and pigmented paravenous retinochoroidal atrophy in the other eye.
American journal of ophthalmology case reportsThe epidemiology of uveitis: comparison of its causes and visual outcomes between three-tiered medical facilities in Ube city.
Scientific reportsUnilateral choroidal detachment in an elderly patient with Vogt-Koyanagi-Harada disease: a case report and literature review.
Frontiers in immunologyInadequacies in uveitis: misnomers, incongruencies, persistence of obsolete terminologies & inappropriate guidelines, treatment inadequacies, and misinterpretations.
Journal of ophthalmic inflammation and infectionCutaneous Granulomatous Inflammation in Vogt-Koyanagi-Harada Disease.
OphthalmologyEffect of prednisone plus either adalimumab or cyclosporine on dermatological symptoms in Vogt-Koyanagi-Harada disease: Systemic outcomes from a randomized trial.
Journal of the American Academy of DermatologyA Case of Vogt-Koyanagi-Harada Disease: Diagnosis Based on the Presence of Vitiligo and Sunset Glow Fundus Without Ocular Symptoms.
CureusBilateral Serous Retinal Detachment as an Initial Manifestation of Systemic Lupus Erythematosus due to Hypoalbuminemia: A Case Report.
Case reports in ophthalmologyOutcomes of Corticosteroids Combined with 15 Mg/Week Methotrexate as Initial Treatment for Acute Vogt-Koyanagi-Harada Disease.
Ocular immunology and inflammationSerous retinal detachment secondary to bilateral choroidal osteoma successfully treated with subscleral sclerectomy: A case report.
American journal of ophthalmology case reportsDemographic Features, Diagnoses and Real-World Clinical Management of Uveitis in Japan.
Ocular immunology and inflammationVogt-Koyanagi-Harada disease-like uveitis induced by nivolumab in metastatic renal cell carcinoma.
IJU case reportsAtypical presentation of acute retinal necrosis mimicking Vogt-Koyanagi-Harada disease leading to misdiagnosis: a case report.
Frontiers in medicineAutomatic measurement of choroidal thickness with swept-source optical coherence tomography in chronic Vogt-Koyanagi-Harada disease: 3 years' follow-up.
Journal of ophthalmic inflammation and infectionRetromode Infrared Scanning Laser Ophthalmoscopy in Vogt-Koyanagi-Harada Disease.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle OphthalmologieEarly Changes in Ocular Biomarkers in Patients with Vogt-Koyanagi-Harada Disease after Pulse Steroid Therapy.
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur AugenheilkundeCabozantinib-Associated Exudative Retinal Detachment and Choroiditis: A Case Report.
Journal of current ophthalmologyEvaluation of the Activity of Vogt-Koyanagi-Harada Disease; A Comparison of Indocyanine Green Angiography Scoring, Enhanced Depth Imaging Optical Coherence Tomography, and Choroidal Vascularity Index.
Journal of current ophthalmologyReduced contrast sensitivity function and outer retina thickness in convalescent Vogt-Koyanagi-Harada disease.
Eye (London, England)Vogt-Koyanagi-Harada Disease Presenting as Papillitis vs. Classic Serous Retinal Detachment: A Comparative Analysis of Outcomes.
Ocular immunology and inflammationManaging Vogt-Koyanagi-Harada disease during pregnancy with steroid pulse therapy: A case report.
World journal of clinical casesA case of unilateral focal choroidal excavation in Vogt-Koyanagi-Harada disease; case report.
HeliyonVogt-Koyanagi-Harada-Like Uveitis Secondary to Pembrolizumab in Metastatic Gastric Cancer: A Case Report and Review of the Literature.
Case reports in oncologyEffects of pregnancy on the clinical course and treatment outcomes of Vogt-Koyanagi-Harada disease.
Indian journal of ophthalmologyAssociation between axial length and uveitis.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle OphthalmologieClinical features and multimodal imaging of primary choroidal lymphoma.
Japanese journal of ophthalmologyTranscription factor EGR2 alleviates autoimmune uveitis via activation of GDF15 to modulate the retinal microglial phenotype.
Proceedings of the National Academy of Sciences of the United States of AmericaUnilateral Vogt-Koyanagi-Harada Disease With Two Distinct Choroidal Neovascular Membranes: A Case Report.
CureusAssociation Between Baseline Macular Morphologic Features on Optical Coherence Tomography and Visual Outcomes in Patients with Vogt-Koyanagi-Harada Disease.
Ocular immunology and inflammationVASCULAR CHANGES AND IRREVERSIBLE COMPLICATIONS IN 120° FUNDUS USING WIDEFIELD SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN VOGT-KOYANAGI-HARADA DISEASE.
Retina (Philadelphia, Pa.)Vogt-Koyanagi-Harada Syndrome: A Case Report.
CureusClinical characteristics, treatment, and outcomes of pembrolizumab-induced uveitis.
Investigational new drugsA Case of Vogt-Koyanagi-Harada Disease and Retinal Peri-Phlebitis in a Patient With Presumed Ocular Tuberculosis.
CureusCHANGES IN SCLERAL THICKNESS IN THE ACUTE PHASE OF VOGT-KOYANAGI-HARADA DISEASE.
Retina (Philadelphia, Pa.)Atypical Central Serous Chorioretinopathy Masquerading as Vogt-Koyanagi-Harada Disease: A Case Report.
Case reports in ophthalmologyApplication of Ophthalmic Electrophysiology in Inflammatory Disorders of Retina and Optic Nerve.
Journal of clinical medicineEfficacy of adalimumab in noninfectious pediatric uveitis: Analysis of 29 eyes from a tertiary eye care center in India.
Indian journal of ophthalmologyChoroidal venous overload in Vogt‒Koyanagi‒Harada disease.
Eye (London, England)Bilateral peripapillary choroidal neovascular membranes in Vogt-Koyanagi-Harada disease.
BMJ case reportsDynamic Changes of Fundus and Predictors of Visual Prognosis in New-Onset Vogt-Koyanagi-Harada Disease.
Ocular immunology and inflammationOutcomes in Patients With Vogt-Koyanagi-Harada Disease From the First-Line Antimetabolites for Steroid-Sparing Treatment Uveitis Trial.
American journal of ophthalmologyEffect of the COVID-19 pandemic on Vogt-Koyanagi-Harada disease.
Scientific reportsDevelopment of Vogt-Koyanagi-Harada disease-like uveitis during treatment by anti-programmed death-1 antibody: a case report.
BMC ophthalmologyPredictive factors and adalimumab efficacy in managing chronic recurrence Vogt-Koyanagi-Harada disease.
BMC ophthalmologyVogt-Koyanagi-Harada Disease: A Narrative Review.
CureusCost-Effectiveness Analysis of Adalimumab Versus Cyclosporine for Vogt-Koyanagi-Harada Disease: A Randomized Controlled Study.
Current eye researchEnhanced depth imaging optical coherence tomography features of two types of Vogt-Koyanagi-Harada disease: fuzzy or lost pattern of the choroidal vasculature is of diagnostic value.
Frontiers in medicinePaediatric non-infectious granulomatous uveitis: a retrospective cohort study.
Rheumatology (Oxford, England)Clinical and Transcriptional Profiles Reveal the Treatment Effect of Adalimumab in Patients with Initial-Onset and Recurrent Vogt-Koyanagi-Harada Disease.
Ocular immunology and inflammationUnveiling Key Pathological Indicators for Disease Progression in Vogt Koyanagi Harada Disease and Sympathetic Ophthalmia Through Advanced Choroidal Volume Analysis.
Ocular immunology and inflammationNew-onset or relapse of uveitis after rapid spreading of COVID-19 infection in China and risk factor analysis for relapse.
BMC ophthalmologyVogt-Koyanagi-Harada disease after SARS-CoV-2 infection: Case report and literature review.
Immunity, inflammation and diseaseVogt-Koyanagi-Harada Disease.
Ocular immunology and inflammationVitiligo as a First Sign of Vogt-Koyanagi-Harada Disease.
Acta dermatovenerologica Croatica : ADCBlood Whispers: Exploring Hematologic Indicators for Diagnosing and Predicting Severity of Vogt-Koyanagi-Harada Syndrome.
Ocular immunology and inflammationA case report: co-occurrence of probable Vogt-Koyanagi-Harada disease and diabetic retinopathy.
BMC ophthalmologyIntravascular large B-cell lymphoma of the eye: Literature review and new findings.
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)Vogt-Koyanagi-Harada disease developed during chemotherapy for Hodgkin lymphoma: a case report.
BMC ophthalmologyVogt-Koyanagi-Harada disease in pregnancy: Case report and review of 32 patients in the literature.
Clinical case reportsPretreatment ocular blood flow and retinal oxygen metabolism in the acute uveitic phase is associated with final outcome in Vogt-Koyanagi-Harada disease.
Acta ophthalmologicaAn Analysis of the clinical and investigative profile of uveitis in the elderly: First case series from India.
Indian journal of ophthalmologySingle Low-dose Suprachoroidal Triamcinolone Acetonide Injection in Macular Edema Secondary to Noninfectious Posterior Uveitis.
Middle East African journal of ophthalmologySympathetic ophthalmia or Vogt-Koyanagi-Harada disease: Don't judge a book by its cover.
Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyVogt-Koyanagi-Harada Disease: The Clinical Spectrum and Management of Case Series in a Tertiary Eye Centre in Northern Part Of Malaysia.
Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnostiUltrasonographic study of the orbit as an early diagnostic tool in Vogt Koyanagi Harada disease (VKH): A case report.
HeliyonA Novel Risk Stratification-Based Immunomodulatory Treatment Strategy for Vogt-Koyanagi-Harada Disease.
American journal of ophthalmologyAssociation between advanced glycation end products and uveitis/scleritis activity in patients with active immune-mediated ocular inflammatory diseases.
International ophthalmologyProteomic profiling of aqueous humor-derived exosomes in Vogt-Koyanagi-Harada disease and Behcet's uveitis.
Clinical immunology (Orlando, Fla.)Reactivation of previously controlled Vogt-Koyanagi-Harada disease more than 46 years following COVID-19 vaccination: a case study.
The Journal of international medical researchOR11H1 Missense Variant Confers the Susceptibility to Vogt-Koyanagi-Harada Disease by Mediating Gadd45g Expression.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Classification of Peripheral Blood Leukocyte Phenotypes and Serum Cytokines in Vogt-Koyanagi-Harada Disease before and after Glucocorticoid Therapy.
Journal of clinical medicinePrognostic value of pretreatment indocyanine green angiography in the acute uveitic phase of Vogt-Koyanagi-Harada disease.
Acta ophthalmologicaComparisons of choroidal blood flow velocity between initial-onset acute uveitis associated with Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy.
Eye (London, England)Vogt-Koyanagi-Harada disease-like uveitis after drug therapy including BRAF/MEK inhibitors in melanoma patients with HLA-DRB1*04.
The Journal of dermatologyEtiological Diagnosis of Uveitis: Contribution of the of the Extra-Ophthalmological Clinical Examination.
Ocular immunology and inflammationSS OCT and OCT-A Findings in Convalescent Inactive Vogt-Koyanagi-Harada Disease.
Ocular immunology and inflammationThe Causes of Optic Disc Edema in Patients Presenting With Significantly Compromised Vision.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology SocietyEpidemiology of Pediatric Uveitis.
Ocular immunology and inflammationClinical Features of Pediatric Uveitis at a Tertiary Referral Center in the Western Region of Japan.
Ocular immunology and inflammationBerlin's Edema with Atypical Optical Coherence Tomography Findings: A Case Report.
Case reports in ophthalmologyThe skin, the eyes, and the ears in Vogt-Koyanagi-Harada disease (VKHD).
Clinical rheumatologyVogt-Koyanagi-Harada Disease and COVID.
Journal of clinical medicineA de novo missense mutation in MPP2 confers an increased risk of Vogt-Koyanagi-Harada disease as shown by trio-based whole-exome sequencing.
Cellular & molecular immunologyIdentification of FCER1G as a cyclosporin A plus corticosteroid sensitization gene in female patients with Vogt-Koyanagi-Harada disease.
Clinical immunology (Orlando, Fla.)Polyautoimmunity manifest as inflammatory myopathy, uveitis, and progressive cutaneous depigmentation in a mixed breed dog: a case report.
BMC veterinary researchUveitis associated with immune checkpoint inhibitors or BRAF/MEK inhibitors in patients with malignant melanoma.
Melanoma researchVogt-Koyanagi-Harada disease in a patient with extreme anisometropia.
American journal of ophthalmology case reportsAutoimmune uveitis in Behçet's disease and Vogt-Koyanagi-Harada disease differ in tissue immune infiltration and T cell clonality.
Clinical & translational immunologyVogt-Koyanagi-Harada disease with a unilateral presentation in a patient with marijuana overuse: Role of multimodal imaging in suspected patients.
Clinical case reportsVOGT-KOYANAGI-HARADA DISEASE-LIKE UVEITIS IN A PATIENT WITH ADVANCED MELANOMA TREATED BY SEQUENTIAL ADMINISTRATION OF NIVOLUMAB AND DABRAFENIB/TRAMETINIB THERAPY.
Retinal cases & brief reportsHLA-DRB1*04:05 is involved in the development of Vogt-Koyanagi-Harada disease-like immune-related adverse events in patients receiving immune checkpoint inhibitors.
Scientific reportsDexamethasone intravitreal implant for macular edema and some other rare indications in uveitis.
Medicine internationalBibliometric analysis of the Vogt‒Koyanagi‒Harada disease literature.
International ophthalmologyDural and Leptomeningeal Diseases: Anatomy, Causes, and Neuroimaging Findings.
Radiographics : a review publication of the Radiological Society of North America, IncBilateral exudative retinal detachments after subretinal gene therapy with voretigene neparvovec-rzyl for RPE65 Leber Congenital Amaurosis.
American journal of ophthalmology case reportsAssociation of Retinal Pigment Epithelium Reflectivity on Optical Coherence Tomography with Recurrence of Vogt-Koyanagi-Harada Disease: A Retrospective Observational Study.
Clinical ophthalmology (Auckland, N.Z.)Incidence and Risk Factors of Recurrent Anterior Uveitis in Initial Acute-Onset Vogt-Koyanagi-Harada Disease.
Korean journal of ophthalmology : KJOEpigenome-wide association study identifies Vogt-Koyanagi-Harada disease-associated DNA methylation loci in Chinese.
Experimental eye researchAlterations in the optic nerve and retina in patients with COVID-19. A theoretical review.
Archivos de la Sociedad Espanola de OftalmologiaA randomized non-inferiority trial of therapeutic strategy with immunosuppressants versus biologics for Vogt-Koyanagi-Harada disease.
Nature communicationsA COVID-19 perspective of Vogt-Koyanagi-Harada disease.
Indian journal of ophthalmologySurgical management for treatment-resistant cases of inflammatory exudative retinal detachment: Mission impossible?
Indian journal of ophthalmologyCLINICAL FEATURES AND PROGNOSTIC VALUE OF BACILLARY LAYER DETACHMENT IN ACUTE VOGT-KOYANAGI-HARADA DISEASE.
Retina (Philadelphia, Pa.)Clinical features, diagnosis, and management of COVID-19 vaccine-associated Vogt-Koyanagi-Harada disease.
Human vaccines & immunotherapeuticsDoes Subretinal Fluid Optical Density Ratio Differ Among the Eyes with Acute Central Serous Chorioretinopathy,Vogt Koyanagi Harada Disease and Choroidal Hemangioma: A Cross-sectional Study.
Photodiagnosis and photodynamic therapyIdentification of Hif1α as a Potential Participant in Autoimmune Uveitis Pathogenesis Using Single-Cell Transcriptome Analysis.
Investigative ophthalmology & visual scienceHIGH LONG-TERM DRUG-FREE REMISSION RATE FOR ACUTE VOGT-KOYANAGI-HARADA DISEASE WITH AN APPROPRIATE IMMUNOSUPPRESSIVE REGIMEN.
Retina (Philadelphia, Pa.)Association of ZC3HAV1 single nucleotide polymorphisms with the susceptibility of Vogt-Koyanagi-Harada Disease.
BMC medical genomicsGut microbial signatures and their functions in Behcet's uveitis and Vogt-Koyanagi-Harada disease.
Journal of autoimmunityImmunosuppressive therapy for Vogt-Koyanagi-Harada disease: a retrospective study and review of literature.
Journal of ophthalmic inflammation and infectionClassification of Vogt-Koyanagi-Harada disease using feature selection and classification based on wide-field swept-source optical coherence tomography angiography.
Frontiers in bioengineering and biotechnologyVery early OCT response to intravenous pulse steroid in Vogt-Koyanagi-Harada disease.
BMJ case reportsManagement of Atypical Central Serous Chorioretinopathy Mimicking Vogt-Koyanagi-Harada Disease.
Journal of vitreoretinal diseasesAcute phase clinical manifestations of patients with Vogt-Koyanagi-Harada disease in Southern China.
BMC ophthalmologyCOVID Vaccine-Associated Uveitis.
Ocular immunology and inflammationChanges of Peripapillary Capillary Density in Patients with Vogt-Koyanagi-Harada Disease Evaluated by Optical Coherence Tomography Angiography.
Journal of ophthalmologyCOVID-19 Developed During Systemic Steroid Therapy for Vogt-Koyanagi-Harada Disease: A Case Report.
Ocular immunology and inflammationVogt-Koyanagi-Harada disease in pediatric, adult and elderly: clinical characteristics and visual outcomes.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle OphthalmologieTET2-mediated upregulation of 5-hydroxymethylcytosine in LRRC39 promoter promotes Th1 response in association with downregulated Treg response in Vogt-Koyanagi-Harada disease.
Clinical immunology (Orlando, Fla.)Clinical and multimodal imaging characteristics of eyes with Vogt-Koyanagi-Harada disease: An Egyptian experience.
Oman journal of ophthalmologyDo not discount the diagnosis of VKH based on race: self-reported race and ethnicity of patients with Vogt-Koyanagi-Harada disease in a predominantly white population.
Journal of ophthalmic inflammation and infectionRetinal Pigment Epithelial Characteristics in Acute and Resolved Vogt-Koyanagi-Harada Disease.
Journal of clinical medicineVogt-Koyanagi-Harada syndrome in the setting of COVID-19 infection.
Clinical case reportsCheckpoint Inhibitor-Associated Vogt-Koyanagi-Harada Disease Presenting 3 Months Following Discontinuation of Nivolumab.
Ophthalmic surgery, lasers & imaging retinaIncidence and pre/post-treatment risk factors of glaucoma in Vogt-Koyanagi-Harada disease.
International ophthalmologySympathetic ophthalmia in an 85-year-old female and a 90-year-old male after a non-complicated cataract surgery: a case report.
The Journal of international medical researchBilateral Serous Detachments with Roth Spots after COVID-19 Vaccination: A Case Report.
Case reports in ophthalmologyRetrolental Bullous Retinal Detachment as the Presenting Feature of Vogt-Koyanagi-Harada Disease in an Elderly Indian Female: Diagnostic and Therapeutic Challenge.
Ocular immunology and inflammationThe Role of Widefield Optical Coherence Tomography Angiography in the Diagnosis and Management of Acute Vogt-Koyanagi-Harada Disease.
Ocular immunology and inflammationAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Evaluation of Melanin Changes in Acute Vogt-Koyanagi-Harada Disease Using Polarization-Sensitive Optical Coherence Tomography.
- Natural experiment on neuroinflammatory disease incidence and infection links pre- and post-COVID-19.
- Seasonal Variations of Vogt-Koyanagi-Harada Disease in Japan: A Study on Long-Term Trends and the Influence of Coronavirus Disease 2019 (COVID-19).
- Choroidal Osteoma with Focal Choroidal Excavation Masquerading as Active Vogt-Koyanagi-Harada: A Case Report.
- Incidence of Cataract Surgery and Postoperative Visual Acuity Outcomes in Patients with Vogt-Koyanagi-Harada Disease.
- Vogt-Koyanagi-Harada disease recurrence after laser treatment: A case report.
- Immune-mediated cochleovestibular dysfunction: clinical spectrum from isolated inner-ear disorders to systemic autoimmune diseases and therapeutic strategies.
- Vogt-Koyanagi-Harada Disease with Oral Manifestations: A Rare Case Report.
- Novel application for the JAK inhibitor baricitinib in the treatment of Vogt-Koyanagi-Harada disease: a prospective cohort study.
- Ultra-Widefield Indocyanine Green Angiography in Uveitis.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:3437(Orphanet)
- MONDO:0018092(MONDO)
- GARD:7862(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q1238645(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
