Raras
Buscar doenças, sintomas, genes...
Doença infecciosa do sistema nervoso
ORPHA:98010DOENÇA RARA

Uma doença infecciosa que envolve o sistema nervoso.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

Uma doença infecciosa que envolve o sistema nervoso.

Medicamentos
11 registrados
DEXAMETHASONE, NOREPINEPHRINE BITARTRATE, HYDROCORTISONE

Tem tratamento?

11 medicamentos registrados
Ver detalhes, fases e interações →
DEXAMETHASONENOREPINEPHRINE BITARTRATEHYDROCORTISONEDEXAMETHASONE SODIUM PHOSPHATEPREDNISONEPREDNISOLONECORTISONE ACETATESERTRALINESATRALIZUMABVALPROIC ACID
🏥
SUS: Sem cobertura SUSScore: 0%
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Entender a doença

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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🧠
Neurológico
85 sintomas
💪
Músculos
24 sintomas
👁️
Olhos
21 sintomas
🫁
Pulmão
15 sintomas
🫃
Digestivo
14 sintomas
🛡️
Imunológico
13 sintomas

+ 240 sintomas em outras categorias

Características mais comuns

Fraqueza da musculatura facial
Paresia das cordas vocais
Paralisia cerebral
Morte cardíaca súbita
Hepatomegalia
Atraso global do desenvolvimento
471sintomas
Sem dados (471)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 471 características clínicas mais associadas, ordenadas por frequência.

Fraqueza da musculatura facialWeakness of facial musculature
Paresia das cordas vocaisVocal cord paresis
Paralisia cerebralCerebral palsy
Morte cardíaca súbitaSudden cardiac death
HepatomegaliaHepatomegaly

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1
Últimos 10 anos200publicações
Pico2026193 papers
Linha do tempo
2025Hoje · 2026🧪 1976Primeiro ensaio clínico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

Genes associados

9 genes identificados com associação a esta condição.

PRNPMajor prion proteinDisease-causing germline mutation(s) inTolerante
FUNÇÃO

Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also

LOCALIZAÇÃO

Cell membraneGolgi apparatus

VIAS BIOLÓGICAS (1)
NCAM1 interactions
EXPRESSÃO TECIDUAL(Ubíquo)
Cérebro - Hemisfério cerebelar
529.6 TPM
Brain Frontal Cortex BA9
405.5 TPM
Cerebelo
382.9 TPM
Cólon sigmoide
312.1 TPM
Córtex cerebral
265.3 TPM
OUTRAS DOENÇAS (9)
Gerstmann-Straussler-Scheinker syndromeHuntington disease-like 1fatal familial insomniaspongiform encephalopathy with neuropsychiatric features
HGNC:9449UniProt:P04156
HLA-DQB1HLA class II histocompatibility antigen, DQ beta 1 chainCandidate gene tested inTolerante
FUNÇÃO

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC

LOCALIZAÇÃO

Cell membraneEndoplasmic reticulum membraneGolgi apparatus, trans-Golgi network membraneEndosome membraneLysosome membrane

VIAS BIOLÓGICAS (1)
MHC class II antigen presentation
EXPRESSÃO TECIDUAL(Ubíquo)
Linfócitos
556.8 TPM
Pulmão
197.8 TPM
Baço
189.1 TPM
Tecido adiposo
82.7 TPM
Intestino delgado
75.3 TPM
OUTRAS DOENÇAS (8)
bullous pemphigoidpediatric multiple sclerosisidiopathic achalasianarcolepsy-cataplexy syndrome
HGNC:4944UniProt:P01920
RANBP2E3 SUMO-protein ligase RanBP2Candidate gene tested inAltamente restrito
FUNÇÃO

E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific dockin

LOCALIZAÇÃO

NucleusNucleus membraneNucleus, nuclear pore complexNucleus envelope

VIAS BIOLÓGICAS (2)
SUMOylation of DNA replication proteinsSUMOylation of SUMOylation proteins
MECANISMO DE DOENÇA

Encephalopathy, acute, infection-induced, 3

A rapidly progressive encephalopathy manifesting in susceptible individuals with seizures and coma. It can occur within days in otherwise healthy children after common viral infections such as influenza and parainfluenza, without evidence of viral infection of the brain or inflammatory cell infiltration. Brain T2-weighted magnetic resonance imaging reveals characteristic symmetric lesions present in the thalami, pons and brainstem.

EXPRESSÃO TECIDUAL(Ubíquo)
Testículo
39.9 TPM
Ovário
37.7 TPM
Fibroblastos
36.7 TPM
Pituitária
36.5 TPM
Útero
34.5 TPM
OUTRAS DOENÇAS (3)
familial acute necrotizing encephalopathyacute necrotizing encephalopathy of childhoodinflammatory myofibroblastic tumor
HGNC:9848UniProt:P49792
TBK1Serine/threonine-protein kinase TBK1Candidate gene tested inAltamente restrito
FUNÇÃO

Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 a

LOCALIZAÇÃO

Cytoplasm

VIAS BIOLÓGICAS (10)
PINK1-PRKN Mediated MitophagyDDX58/IFIH1-mediated induction of interferon-alpha/betaSARS-CoV-2 activates/modulates innate and adaptive immune responsesTRAF3-dependent IRF activation pathwayTRAF6 mediated IRF7 activation
MECANISMO DE DOENÇA

Glaucoma 1, open angle, P

A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. GLC1P is characterized by early onset, thin central corneas and low intraocular pressure.

EXPRESSÃO TECIDUAL(Ubíquo)
Linfócitos
50.3 TPM
Testículo
42.8 TPM
Fibroblastos
35.0 TPM
Pulmão
30.8 TPM
Útero
30.3 TPM
OUTRAS DOENÇAS (6)
autoinflammation with arthritis and vasculitisfrontotemporal dementia and/or amyotrophic lateral sclerosis 4amyotrophic lateral sclerosisfrontotemporal dementia with motor neuron disease
HGNC:11584UniProt:Q9UHD2
TLR3Toll-like receptor 3Candidate gene tested inTolerante
FUNÇÃO

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response

LOCALIZAÇÃO

Endoplasmic reticulum membraneEndosome membraneEarly endosome

VIAS BIOLÓGICAS (10)
TICAM1,TRAF6-dependent induction of TAK1 complexToll Like Receptor 3 (TLR3) CascadeRIP-mediated NFkB activation via ZBP1TICAM1, RIP1-mediated IKK complex recruitmentTLR3-mediated TICAM1-dependent programmed cell death
MECANISMO DE DOENÇA

Immunodeficiency 83, susceptibility to viral infections

An immunologic disorder characterized by increased susceptibility to severe viral infections, including herpes simplex virus (HSV), varicella zoster virus (VZV), influenza A virus (IAV), hantavirus, and possibly respiratory syncytial virus (RSV). IMD83 clinical manifestations include acute infection-induced encephalitis and pneumonitis. The susceptibility to encephalitis or pneumonitis appears to result from impaired TLR3-dependent interferon production by nonhematopoietic cells that reside within the central nervous system or lung epithelial cells. IMD83 transmission pattern is consistent with autosomal dominant or autosomal recessive inheritance with incomplete penetrance.

EXPRESSÃO TECIDUAL(Ubíquo)
Pulmão
5.1 TPM
Vagina
4.1 TPM
Adipose Visceral Omentum
4.1 TPM
Esôfago - Mucosa
4.0 TPM
Glândula adrenal
4.0 TPM
OUTRAS DOENÇAS (3)
herpes simplex encephalitissusceptibility to HIV infectionimmunodeficiency 83, susceptibility to viral infections
HGNC:11849UniProt:O15455
TICAM1TIR domain-containing adapter molecule 1Candidate gene tested inDesconhecido
FUNÇÃO

Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303, PubMed:28747347, PubMed:35215908). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12471095, PubMed:12539043, PubMed:14739303). Distinct protein-interaction motifs allow recruitment of the effector

LOCALIZAÇÃO

Cytoplasmic vesicle, autophagosomeCytoplasm, cytosolMitochondrion

VIAS BIOLÓGICAS (8)
TICAM1,TRAF6-dependent induction of TAK1 complexToll Like Receptor 3 (TLR3) CascadeRIP-mediated NFkB activation via ZBP1TICAM1, RIP1-mediated IKK complex recruitmentTLR3-mediated TICAM1-dependent programmed cell death
MECANISMO DE DOENÇA

Encephalopathy, acute, infection-induced, 6, herpes-specific

A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.

EXPRESSÃO TECIDUAL(Ubíquo)
Esôfago - Mucosa
60.9 TPM
Linfócitos
46.6 TPM
Aorta
34.9 TPM
Skin Not Sun Exposed Suprapubic
32.1 TPM
Pulmão
31.5 TPM
OUTRAS DOENÇAS (2)
herpes simplex encephalitisherpes simplex encephalitis, susceptibility to, 4
HGNC:18348UniProt:Q8IUC6
TRAF3TNF receptor-associated factor 3Candidate gene tested inAltamente restrito
FUNÇÃO

Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types (PubMed:33148796, PubMed:33608556). In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activa

LOCALIZAÇÃO

CytoplasmEndosomeMitochondrion

VIAS BIOLÓGICAS (6)
Ovarian tumor domain proteasesNegative regulators of DDX58/IFIH1 signalingActivation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)TICAM1-dependent activation of IRF3/IRF7TNFR2 non-canonical NF-kB pathway
MECANISMO DE DOENÇA

Immunodeficiency 132A

An autosomal dominant immunologic disorder characterized by increased susceptibility to infection with certain pathogens, including Herpes simplex virus and Mycobacterium abscessus. Immunologic work-up shows impaired production of cytokines, including INFB and IL6.

EXPRESSÃO TECIDUAL(Ubíquo)
Linfócitos
51.8 TPM
Cérebro - Hemisfério cerebelar
18.3 TPM
Cerebelo
18.0 TPM
Testículo
16.5 TPM
Pituitária
16.3 TPM
OUTRAS DOENÇAS (3)
herpes simplex encephalitis, susceptibility to, 3immunodeficiency 132bherpes simplex encephalitis
HGNC:12033UniProt:Q13114
UNC93B1Protein unc-93 homolog B1Candidate gene tested inTolerante
FUNÇÃO

Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal

LOCALIZAÇÃO

Endoplasmic reticulum membraneEndosomeLysosomeCytoplasmic vesicle, phagosome

VIAS BIOLÓGICAS (1)
Trafficking and processing of endosomal TLR
MECANISMO DE DOENÇA

Encephalopathy, acute, infection-induced, 1, herpes-specific

A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.

EXPRESSÃO TECIDUAL(Ubíquo)
Baço
128.5 TPM
Linfócitos
76.4 TPM
Sangue
66.9 TPM
Pulmão
60.4 TPM
Intestino delgado
52.1 TPM
OUTRAS DOENÇAS (2)
herpes simplex encephalitisherpes simplex encephalitis, susceptibility to, 1
HGNC:13481UniProt:Q9H1C4
CPT2Carnitine O-palmitoyltransferase 2, mitochondrialCandidate gene tested inTolerante
FUNÇÃO

Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites (PubMed:20538056, PubMed:24780397). Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters (PubMed:20538056)

LOCALIZAÇÃO

Mitochondrion inner membrane

VIAS BIOLÓGICAS (2)
Carnitine shuttlePPARA activates gene expression
MECANISMO DE DOENÇA

Carnitine palmitoyltransferase 2 deficiency, myopathic, stress-induced

An autosomal recessive disorder of mitochondrial long-chain fatty acid oxidation, characterized by recurrent myoglobinuria, episodes of muscle pain, stiffness, and rhabdomyolysis. These symptoms are exacerbated by prolonged exercise, fasting, cold, or viral infection. CPT2DM affects most frequently children or young adults, and severity of attacks is highly variable. Myoglobinuria can cause kidney failure and death.

OUTRAS DOENÇAS (5)
carnitine palmitoyl transferase II deficiency, neonatal formcarnitine palmitoyl transferase II deficiency, severe infantile formcarnitine palmitoyl transferase II deficiency, myopathic formacute necrotizing encephalopathy of childhood
HGNC:2330UniProt:P23786

Medicamentos e terapias

DEXAMETHASONEPhase 4

Mecanismo: Glucocorticoid receptor agonist

NOREPINEPHRINE BITARTRATEPhase 4

Mecanismo: Adrenergic receptor agonist

HYDROCORTISONEPhase 4

Mecanismo: Glucocorticoid receptor agonist

DEXAMETHASONE SODIUM PHOSPHATEPhase 4

Mecanismo: Glucocorticoid receptor agonist

PREDNISONEPhase 4

Mecanismo: Glucocorticoid receptor agonist

PREDNISOLONEPhase 4

Mecanismo: Glucocorticoid receptor agonist

CORTISONE ACETATEPhase 4

Mecanismo: Glucocorticoid receptor agonist

SERTRALINEPhase 3

Mecanismo: Serotonin transporter inhibitor

SATRALIZUMABPhase 3

Mecanismo: IL6Ralpha/GP130 antagonist

VALPROIC ACIDPhase 3

Mecanismo: Succinate semialdehyde dehydrogenase inhibitor

Ver mais no OpenTargets

Variantes genéticas (ClinVar)

392 variantes patogênicas registradas no ClinVar.

🧬 PRNP: NM_000311.5(PRNP):c.229C>T (p.His77Tyr) ()
🧬 PRNP: NM_000311.5(PRNP):c.325A>T (p.Met109Leu) ()
🧬 PRNP: NM_000311.5(PRNP):c.284C>A (p.Thr95Asn) ()
🧬 PRNP: NM_000311.5(PRNP):c.304C>T (p.Pro102Ser) ()
🧬 PRNP: NM_000311.5(PRNP):c.88G>A (p.Gly30Arg) ()
Ver todas no ClinVar

Vias biológicas (Reactome)

80 vias biológicas associadas aos genes desta condição.

NCAM1 interactions Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events IRF3 mediated activation of type 1 IFN DDX58/IFIH1-mediated induction of interferon-alpha/beta Regulation of innate immune responses to cytosolic DNA STAT6-mediated induction of chemokines IRF3-mediated induction of type I IFN PINK1-PRKN Mediated Mitophagy TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling Interleukin-37 signaling TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Potential therapeutics for SARS SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation Trafficking and processing of endosomal TLR Toll Like Receptor 3 (TLR3) Cascade TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TLR3 deficiency - HSE UNC93B1 deficiency - HSE TICAM1 deficiency - HSE TRAF3 deficiency - HSE TLR3-mediated TICAM1-dependent programmed cell death TICAM1,TRAF6-dependent induction of TAK1 complex RSV-host interactions Caspase activation via Death Receptors in the presence of ligand MyD88-independent TLR4 cascade TRIF-mediated programmed cell death IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ovarian tumor domain proteases PPARA activates gene expression Carnitine shuttle

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

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Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
Aprovado8
3Fase 33
2Fase 21
·Pré-clínico3
Medicamentos catalogadosEnsaios clínicos· 10 medicamentos · 5 ensaios
✓ Aprovados — podem ser usados hoje
DEXAMETHASONENOREPINEPHRINE BITARTRATEHYDROCORTISONEDEXAMETHASONE SODIUM PHOSPHATEPREDNISONEPREDNISOLONECORTISONE ACETATE
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Doença infecciosa do sistema nervoso

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Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

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Outros ensaios clínicos

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Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
0 papers (10 anos)
#1

Mild SARS-CoV-2 maternal infection in mice induces transient offspring neurodevelopmental aberrance.

Proceedings of the National Academy of Sciences of the United States of America2026 Mar 24

Este estudo em ratos sugere que, mesmo uma infecção materna *leve* por SARS-CoV-2 durante a gravidez, pode causar inflamação placentária e alterações *temporárias* no desenvolvimento cerebral inicial da prole. No entanto, o mais importante para pacientes e médicos é que essas alterações se resolveram por si mesmas e não resultaram em problemas comportamentais ou neurológicos duradouros nos filhotes, indicando um impacto a longo prazo limitado.

🇧🇷 traduzido
#2

The Anti-Apoptotic Activity of β-Synuclein Mediated via Akt Signaling Is Severely Lost During Prion Infection.

International journal of molecular sciences2026 Mar 02

Este estudo revela que a beta-sinucleína, uma proteína que normalmente protege as células cerebrais da morte (apoptose) através da sinalização Akt, perde gravemente sua função protetora durante a infecção por príon. Essa descoberta indica uma vulnerabilidade intrínseca dos neurônios nas doenças priônicas e sugere que restaurar essa atividade protetora poderia ser uma nova e promissora estratégia terapêutica para pacientes.

🇧🇷 traduzido
#3

HIV Infection, Neurotoxicity, Inflammation, Premature Aging, and Therapeutic Challenges to PLWH: An Overview.

International journal of molecular sciences2026 Feb 26

Este artigo destaca que, mesmo com o tratamento antirretroviral (ART) moderno suprimindo o HIV no corpo, o vírus persiste no sistema nervoso central (SNC) devido à penetração limitada dos medicamentos e à sua capacidade de se esconder. Essa persistência, juntamente com a inflamação crônica e a neurotoxicidade, acelera o envelhecimento cerebral, o que contribui para o desenvolvimento de transtornos neurocognitivos associados ao HIV (HAND) em quase metade dos pacientes, mesmo com carga viral controlada. Para pacientes e médicos, isso significa que é crucial monitorar a saúde cerebral e abordar esses desafios para melhorar a qualidade de vida a longo prazo.

🇧🇷 traduzido
#4

Alpha-Synuclein in Neurodegeneration: From Shared Biology to Disease-Specific Phenotypes.

Cells2026 Mar 03

Este artigo destaca que a alfa-sinucleína (αSyn) é uma proteína central em diversas doenças neurodegenerativas, como Parkinson, demência com corpos de Lewy e atrofia de múltiplos sistemas. Ele explica que a variedade de como essas doenças se manifestam clinicamente em cada paciente depende de uma complexa interação de fatores, e não apenas da αSyn isoladamente. Compreender essa multidimensionalidade é crucial para o desenvolvimento de novos biomarcadores e terapias de precisão, que permitirão diagnósticos mais acurados e tratamentos mais personalizados para pacientes com essas condições.

🇧🇷 traduzido
#5

A Novel Competing Endogenous RNA Linked to Dysregulated Neuroinflammation in Alzheimer's Disease.

Cells2026 Feb 27

Pesquisadores identificaram um novo RNA longo não codificante, denominado LIMASI, que está elevado no cérebro de pacientes com Alzheimer (DA) e modelos da doença, correlacionando-se com a progressão da patologia (placas amiloides, tau) e com o aumento da neuroinflamação. O LIMASI parece atuar sequestrando microRNAs pró-inflamatórios, modulando a resposta inflamatória, o que sugere que ele pode ser um novo alvo terapêutico promissor para reduzir a neuroinflamação e potencialmente retardar a neurodegeneração associada ao Alzheimer.

🇧🇷 traduzido

Publicações recentes

Ver todas no PubMed

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2026

Infection and Vaccination-Induced Tick-Borne Encephalitis Virus IgG Antibody Prevalence in the Austrian Federal State of Upper Austria, a High-Risk Region for TBEV.

Epidemiologia (Basel, Switzerland)
2026

Taking its TOLL: the role of toll-like receptor 4 in human health and disease, and its potential as a therapeutic target.

Frontiers in immunology
2026

Influenza A-Associated Acute Necrotizing Encephalitis With Complete Recovery Following Early Immunomodulatory Therapy.

Cureus
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Lipidomic insights into infectious meningitis: Pathogen-specific alterations and therapeutic implications.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2026

Effect of Timing and Duration of ART on the Composition of HIV Reservoirs: Implications for HIV Cure Strategies.

Current HIV/AIDS reports
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Body Under Attack: Disseminated Varicella-Zoster Virus Infection.

Cureus
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Infection, vaccination and risk of dementia: a proposed immunological model.

Frontiers in immunology
2026

T Cells Inhibit Hippocampal Regeneration in Mice Following Trimethyltin-Induced Neurodegeneration.

Neuropathology : official journal of the Japanese Society of Neuropathology
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Remarkable recovery from a Cladophialophora bantiana fungal brain abscess in an immunocompromised patient: a case report.

ASM case reports
2026

Multisystem Lomentospora prolificans progression on fosmanogepix despite in vitro activity: a call for expanding clinical research on novel antifungals.

ASM case reports
2026

Risk of Noncommunicable Diseases After Hospitalization for Community-Acquired Pneumonia.

Open forum infectious diseases
2026

Mild SARS-CoV-2 maternal infection in mice induces transient offspring neurodevelopmental aberrance.

Proceedings of the National Academy of Sciences of the United States of America
2026

Intraventricular treatment experience in children with central nervous system infections.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2026

A biosafe mouse model for SARS-CoV-2 infection that more realistically simulates COVID-19 symptoms.

Signal transduction and targeted therapy
2026

A digital twin for Escherichia coli K1 neonatal meningitis.

Journal of medical microbiology
2026

Rewiring the Lung-CNS Axis After Spinal Cord Injury.

Journal of inflammation research
2026

New onset seizure etiologies and outcomes among adults with HIV in the era of broadly available antiretroviral therapies.

Seizure
2026

The Anti-Apoptotic Activity of β-Synuclein Mediated via Akt Signaling Is Severely Lost During Prion Infection.

International journal of molecular sciences
2026

HIV Infection, Neurotoxicity, Inflammation, Premature Aging, and Therapeutic Challenges to PLWH: An Overview.

International journal of molecular sciences
2026

Alpha-Synuclein in Neurodegeneration: From Shared Biology to Disease-Specific Phenotypes.

Cells
2026

A Novel Competing Endogenous RNA Linked to Dysregulated Neuroinflammation in Alzheimer's Disease.

Cells
2026

Inflammation-Associated Mechanisms of Blood-Brain Barrier Disruption and Depression Pathogenesis in People with and Without HIV.

Cells
2026

Deciphering casual association between brain structure and liver cirrhosis: Insights from Mendelian randomization.

Medicine
2026

HIV-1 Vpr activates microglia by upregulating m6A modification through ubiquitin-proteasome pathway-mediated degradation of the demethylase ALKBH5.

Virulence
2026

Enhancing detection of severe enterovirus infections: A data linkage study of ICD-10 codes with national enterovirus laboratory data, Denmark, 2010 to 2023.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
2026

Neuromyelitis Optica Spectrum Disorder in a Pediatric Patient Following Haploidentical Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia.

Blood cell therapy
2026

[Application of chromatography-mass spectrometry in the clinical analysis of multiple sclerosis].

Se pu = Chinese journal of chromatography
2026

A case of trigeminal nerve neurosarcoidosis initially presenting with isolated neurological findings mimicking trigeminal schwannoma: a case report and review of the literature.

Journal of medical case reports
2026

A case report of rhino-orbital-cerebral invasive infection caused by co-infection with Pleurostoma ootheca and Mucorales.

Diagnostic microbiology and infectious disease
2026

Identification of Potential Therapeutic Agents for Primary Amebic Meningoencephalitis Using Text Mining and Bioinformatics Analyses.

Analytical cellular pathology (Amsterdam)
2026

Epigenetic activation of EBV BGLF4 determines antiviral-based regimen response in EBV+CNS lymphoproliferative disease.

Blood neoplasia
2026

Spatial and temporal risk mapping of human and porcine Taenia solium infections in Malawi: a systematic review and geostatistical approach.

One health outlook
2026

Adult Japanese encephalitis in a non-endemic area: A case highlighting diagnostic limitations of targeted next-generation sequencing.

Diagnostic microbiology and infectious disease
2026

From health check-ups to "City sewage health scan": Multidimensional chemical analysis for wastewater-based epidemiology in Hong Kong.

Water research
2026

Urinary nickel and risk of all-cause and neurological mortality in Chinese older adults: Evidence from a prospective cohort study.

Ecotoxicology and environmental safety
2026

PDE4B deficiency aids macrophage differentiation and contributes to Cryptococcus neoformans brain infection.

PLoS pathogens
2026

Intrathecal immunoglobulin production in the diagnosis, prognosis, and monitoring of autoimmune diseases of the central nervous system.

Journal of translational autoimmunity
2026

Diabetes Mellitus Accelerates Alzheimer's Disease Development by Affecting the Gut Microbiome.

BioMed research international
2026

A Case of Acute Polyarthritis With a Suspected Association to Mycoplasma Infection Without Extrapulmonary Manifestations.

Cureus
2026

Microbial SCFAs as epigenetic mediators: fine-tuning the gut-brain axis in neurodegenerative disorders.

Current research in microbial sciences
2026

VGLUT1 and PSD-95 Expression Remains Stable in the Prefrontal and Cerebellar Cortices of the VPA Autism Rat Model.

Developmental neurobiology
2026

Biodistribution of AAV-TT and AAV9 in the Nonhuman Primate Brain.

Human gene therapy
2026

Safety, immunovirological, and CNS effects of PD-1 inhibition in people with HIV without malignancy.

The Journal of infectious diseases
2026

Sulforaphane Attenuates Methamphetamine-Induced Neurotoxicity via Activation of the PI3K/AKT Pathway.

Journal of biochemical and molecular toxicology
2026

HIV-associated lymphoproliferative disorders: Single-center experience.

Medicine
2026

Association between spirochaetal infection and neurodegenerative diseases: a systematic review and quantitative synthesis of observational studies.

Journal of medical microbiology
2026

Comprehensive study of cerebrospinal fluid β2-microglobulin, a marker of central nervous system immune activation in individuals with HIV.

AIDS (London, England)
2026

Neurological Infections in HIV: A Case-Based Review for Clinicians.

Le infezioni in medicina
2026

Comprehensive review of recent advances in Pompe disease: pathogenesis, management, and future directions.

Frontiers in neurology
2026

Cross-sectional observational study evaluating social brain health in HIV using a research domain criteria-based approach: a protocol.

BMJ open
2026

[Cognitive and psychiatric evolution in autoimmune encephalitis in a school-aged child: Clinical case].

Revista medica del Instituto Mexicano del Seguro Social
2026

Symptom burden in dialysis patients: determinants and impact on mortality.

Journal of nephrology
2026

Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment.

The Journal of experimental medicine
2026

Neuropathogenesis of Usutu virus-associated disease in Eurasian blackbirds (Turdus merula) involves apoptosis through the extrinsic pathway.

Journal of neurovirology
2026

Epidemiology of Herpes Simplex Virus in Infants Aged 0-42 Days: 2008-2024.

Pediatrics
2026

Omnipresence of Stress: The Hidden Crisis.

Annals of African medicine
2026

An Uncommon Case of Disseminated Human Herpesvirus 6 Infection in an Immunocompetent Adult.

Cureus
2026

Physiological Regulatory Mechanisms of Neurovascular Coupling and the Role of Its Dysfunction in Neurological Diseases.

Journal of integrative neuroscience
2026

Whole genome sequencing reveals variation in immune and nervous systems associated with harbor seal susceptibility to phocine distemper virus.

The Journal of heredity
2026

Drug-Resistant Tuberculous Meningitis (DR-TBM) in a Low-Incidence Setting: Two Cases and an Evidence Review Highlighting Key Advances and Knowledge Gaps in Clinical Management.

Open forum infectious diseases
2026

Jamestown Canyon Virus Disease: An Analytic Review of Human Cases Reported from 1982 Through 2022.

Viruses
2026

SHFL Post-Transcriptionally Restricts Coxsackievirus A16 In Vitro and In Vivo.

Viruses
2026

Microglia-Neuron Crosstalk: An Intimate Molecular Conversation in Neurodegeneration.

International journal of molecular sciences
2026

RAGE Axis in the Pathogenesis and Treatment of CNS Neurodegeneration in Long-Term Hyperglycemia.

International journal of molecular sciences
2026

Region-Specific NRF2 Signaling in HIV-Associated Neurocognitive Disorders: A Transcriptomic and Computational Histology Study.

Genes
2026

Diagnostic Imaging of Extrapulmonary Tuberculosis Across Organ Systems.

Diagnostics (Basel, Switzerland)
2026

Acute Disseminated Encephalomyelitis (ADEM): Current View into Etiopathogenesis and Clinical Features.

Brain sciences
2026

A cellular basis for the mammalian nocturnal-diurnal switch.

Science (New York, N.Y.)
2026

Associations Between Sustained Methamphetamine/Amphetamine Use and Left Ventricular Dysfunction in a Cohort of Women Living With and Without HIV.

Journal of the American Heart Association
2026

Rethinking Neonatal Vaccination Policies: A Neuroimmune Perspective.

Iranian journal of medical sciences
2026

Safety and Efficacy of Intraventricular Antibiotics for Central Nervous System Infections in Children: A Single-center Observational Study.

The Pediatric infectious disease journal
2025

Synthetic peptide V11A reduces bacterial load and inflammation in pneumococcal meningitis.

Frontiers in cellular and infection microbiology
2026

The effect of amphetamine-type stimulants on immune response in HIV-infected individuals: a retrospective cohort study.

Frontiers in immunology
2026

[The role of malic enzyme 1 regulating ferroptosis on nerve impairment of hypertensive mice following lead exposure].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
2026

Varicella zoster virus and the central nervous system.

Nature reviews. Microbiology
2026

Taenia solium neurocysticercosis: Its current epidemiological, diagnostic, therapeutic, and control landscapes.

PLoS neglected tropical diseases
2026

Addition of Clofazimine Enhances the Activity of Standard Treatment Regimen in a Mouse Model of Tuberculous Meningitis.

The Journal of infectious diseases
2026

Endothelial semaphorin 6D controls immune responses under cold stress through regulation of sympathetic innervation.

Journal of immunology (Baltimore, Md. : 1950)
2026

Nocardia farcinica Brain Abscess Mimicking Acute Ischemic Stroke in an Immunocompetent Elderly Patient: A Case Report.

Cureus
2026

Microglial Autofluorescence in the Brain and Retina is Dynamically Modulated by Systemic Inflammation.

Cellular and molecular neurobiology
2026

Hyperactivation of sympathetic nerves fuels basophil infiltration in atopic dermatitis.

Immunity
2026

Scopoletin alleviates cognitive deficits in 5xFAD mice via suppressing microglial inflammatory response.

Phytomedicine : international journal of phytotherapy and phytopharmacology
2026

Rhino-sino-orbital and/or central nervous system infections due to Lomentospora prolificans and Scedosporium spp. in onco-haematology patients.

Medical mycology
2026

Streptococcus suis infection as an emerging zoonotic threat in Brazil: a One Health-based review.

Revista do Instituto de Medicina Tropical de Sao Paulo
2026

Highly dynamic dural sinuses support meningeal immunity.

Nature
2026

METTL14 modulates the nasopharyngeal carcinoma microenvironment via m6A-modified YWHAH identified through single-cell and machine learning analyses.

Frontiers in immunology
2026

Exploring Cerebrovascular Manifestations of Neuroborreliosis: A Scoping Review.

Annals of Indian Academy of Neurology
2026

Astrocytic PYGM attenuates tau pathology by promoting lactate-mediated neuroprotection.

Alzheimer's & dementia : the journal of the Alzheimer's Association
2026

Hippocampal Gene Expression in Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis: Assessment of Human Herpesvirus 6B DNA Status.

Journal of medical virology
2026

A rest-task fMRI study of spatial working memory in HIV-infected individuals across cognitive states.

BMC medical imaging
2026

Neuronal intranuclear inclusion disease: a diagnostic pitfall for MELAS.

BMC neurology
2026

[Guidelines for the diagnosis and treatment of carbapenem-resistant pseudomonas aeruginosa infection(2026 edition)].

Zhonghua yi xue za zhi
2026

Clinical spectrum, outcomes, and risk factors of West Nile virus infection: A systematic review and meta-analysis.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2026

Neutrophil extracellular traps (NETs) in cerebrovascular disease mechanisms, detection, and therapeutic targeting.

Experimental neurology
2026

Environmental standard limit fluoride exposure prioritizes neurotoxicity over osteotoxicity in larval zebrafish: A benchmark dose analysis.

Aquatic toxicology (Amsterdam, Netherlands)
2026

Classification of tauopathies from human brain homogenates through salt-modulated tau amplification.

Alzheimer's & dementia : the journal of the Alzheimer's Association
2026

Global trends and inequities in childhood cancer burden from 1990 to 2021, with projections to 2040: a Global Burden of Disease study.

International journal of surgery (London, England)
2026

Enteric nervous system in microbiota-associated gut inflammation.

Frontiers in immunology
2026

Viral infection and brain inflammation with seizures in PARK7 deficiency.

Journal of human immunity
2026

Primary Amoebic Meningoencephalitis caused by Complement C2 Deficiency.

medRxiv : the preprint server for health sciences
2026

Two TaqMan real-time quantitative PCR assays for the detection of Alongshan virus, a new member of the tick-borne Flaviviridae family.

Access microbiology
2026

Sleep-dependent clearance of brain lipids by peripheral blood cells.

Nature
2026

A Case of Dysembryoplastic Neuroepithelial Tumor in an HIV-Positive Adult: Diagnostic Lessons for Clinicians.

Cureus
2026

Beyond Rifampin: Evaluating Rifapentine and Rifabutin as Alternative Treatments for TB Meningitis.

The Journal of infectious diseases
2026

D178N prion protein mutation endows RML prions with new strain properties that do not mimic human genetic prion diseases.

Acta neuropathologica
2026

An unintended consequence: a review of iatrogenic central nervous system mold infections and outbreaks.

Clinical microbiology reviews
2026

Intrathecal Kappa Free Light Chains in Relation to IgM Synthesis and MRZH Reaction in a Mixed Neurological Cohort.

Journal of neurochemistry
2026

Med13 is involved in the radial migration and contralateral projection of cortical neurons via PlxnA4.

Communications biology
2026

Persistent Undocumented Meningoencephalitis due to Histoplasmosis in an HIV-Infected Patient in Brazil.

The American journal of tropical medicine and hygiene
2026

Neural cells are susceptible to historic and recently emerged Oropouche virus strains.

PLoS pathogens
2026

A gel-forming antioxidant eye drop for photoreceptor protection in retinitis pigmentosa.

Drug delivery and translational research
2026

Association between influenza A virus and SARS-CoV-2 infections and mood disorders.

Brain, behavior, & immunity - health
2026

Fungal meningoencephalitis caused by Phanerochaete sp.: Case report.

Medical mycology case reports
2026

Melioidosis in India: A systematic review of individual cases.

IJID regions
2026

Findings on Magnetic Resonance Imaging in Neuroborreliosis-A Nationwide Cohort Study.

European journal of neurology
2026

Fever and syndrome of inappropriate antidiuretic hormone secretion in a patient with multiple system atrophy after treatment with duloxetine.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2026

Prenatal and postnatal effects of gestational immune activation on synaptic and neurodevelopmental pathways via epigenetic mechanisms.

Translational psychiatry
2026

Albendazole-doxycycline combination therapy alleviates MRI- and pathology-evident neuroinflammation and restores IL-33/GFAP balance in mouse neuroangiostrongyliasis.

Parasites & vectors
2026

Characterization of Atypical Ebola Virus Disease in Ferrets.

bioRxiv : the preprint server for biology
2026

Distinct Clinico-pathogenic Subgroups in Pediatric Lyme Neuroborreliosis.

Open forum infectious diseases
2026

The immunoproteasome as a neuroimmune hub in the central nervous system: from proteostasis stress to inflammatory pathology.

Journal of neuroinflammation
2026

The gut microbiota mediates depression-like behaviors in mice with chronic Echinococcus multilocularis infection.

NPJ biofilms and microbiomes
2026

Brucella vs. tuberculous central nervous system infection in a tertiary medical center in Lebanon: A case series.

Journal of infection and public health
2026

Mutant knock-in mice display enhanced susceptibility to pure prion protein fibrils.

The Journal of general virology
2026

[Optimal serum 25(OH)D levels in relation to musculoskeletal, metabolic, neurological, autoimmune and infectious diseases].

Problemy endokrinologii
2026

Epstein-Barr virus (EBV)-associated smooth muscle tumor of the central nervous system in an HIV patient: diagnostic and therapeutic challenges.

BMC infectious diseases
2026

A self-controlled case series study on the safety of a live attenuated herpes zoster vaccine in China.

Expert review of vaccines
2026

Differential astrocyte activation by Taenia solium antigens: Specific induction of IL-10 and IL-1β by Excretory/Secretory (ES) products.

Immunobiology
2026

Syphilitic Uveitis-Associated Chiasmal Optic Neuritis Presenting As Bitemporal Hemianopia-Like Visual Field Defects.

Cureus
2026

Bilateral Nocardia farcinica Chorioretinitis With Endogenous Endophthalmitis and Concurrent CNS Disease: A Case Report.

Cureus
2026

Whipple's Disease: Panniculitis Among Other Dermatoses. A Case Report and Literature Review.

Journal of cutaneous pathology
2026

Microbial-Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies.

European journal of immunology
2026

Lipoxin B4 Mitigates TRPV4-Activated Müller Cell Gliosis During Ocular Hypertension.

Investigative ophthalmology & visual science
2026

Inborn errors of autophagy underlying severe viral infections in humans.

Current opinion in virology
2026

Heated tobacco and cigarette smoke modulate CD4 + T cell activation and neuroinflammation in a context-dependent manner.

Journal of neuroinflammation
2026

The impact of formic acid treatment on brain tissues for prion inactivation.

Acta histochemica
2026

Indoleamine 2,3-Dioxygenase: A Potential Biomarker for Neural Damage Severity of Leprosy Neuropathy.

Cellular and molecular neurobiology
2026

A multicentre evaluation of metagenomic sequencing for pathogen detection in central nervous system infections.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
2026

Association of increased cortical thickness and cognitive impairment in patients with Kallmann syndrome.

European journal of endocrinology
2026

IDO family: the metabolic crossroads connecting immunity, nerves and tumors.

Journal of translational medicine
2026

Prion seeding activity in DNA extractions: implications for laboratory biosafety.

Prion
2025

Heart rate variability reflects endoscopic activity and systemic inflammation in patients with Crohn's disease.

Frontiers in medicine
2026

Use of a Cystatin C-Based GFR Equation in a Population Pharmacokinetic Model of Methotrexate Clearance in Adult Patients with Lymphoma.

Clinical pharmacokinetics
2026

Intestinal macrophages modulate synucleinopathy along the gut-brain axis.

Nature
2026

Pathogenesis and Research Models of Acute Influenza-Associated Encephalitis/Encephalopathy: An Update.

Viruses
2026

Synergy of SARS-CoV-2 and HIV-1 Infections in the Human Brain.

Pathogens (Basel, Switzerland)
2026

SHIV.D Infection Alters Production and Protein Composition of Myeloid-Derived Extracellular Vesicles.

International journal of molecular sciences
2026

Neurobrucellosis in an 11-year-old child: A rare case report of brain microabscesses from an endemic region.

The Journal of international medical research
2026

High prevalence of polypharmacy and nervous system medications in people with HIV: a cross-sectional analysis.

Scientific reports
2026

Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutières syndrome neuropathology.

eLife
2026

Transverse Comparison of Clinical Characteristics and Prognostic Factors in HIV-Infected Patients with Cytomegalovirus Encephalitis in Guangdong, China.

Current HIV research
2026

The next-generation polyene EL219 is efficacious in an experimental model of central nervous system coccidioidomycosis caused by Coccidioides immitis.

Antimicrobial agents and chemotherapy
2026

Antimicrobial peptides act as a component of brain immunity against microbes in Alzheimer's disease.

Advances in protein chemistry and structural biology
2026

Bradyzoite subtypes rule the crossroads of Toxoplasma development.

Nature communications
2026

Targeting HMGB1 in Microglia Alleviates Neuroinflammation and Modulates the Pro-/Anti-inflammatory Balance of Microglia/Macrophages in Experimental Autoimmune Encephalomyelitis.

Molecular neurobiology
2026

Comparative assessment of immunochromatographic test kits using low-molecular-weight antigens from cyst fluids of two different genotypes of Taenia solium for serodiagnosis of human cysticercosis.

Parasite (Paris, France)
2026

Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina.

Nature communications
2026

Smog, sugar, and synapses: Unraveling the PM2.5-insulin resistance-Alzheimer's disease axis.

Redox biology
2025

[Genotypic diversity of the varicella-zoster virus (Herpesviridae: Varicellovirus) and human gene variants as risk factors for severe disease].

Voprosy virusologii
2026

The epidemiology and clinical features of HIV and Trypanosoma cruzi (Chagas disease) co-infection: A systematic review and individual patient data analysis.

PLoS neglected tropical diseases
2026

Uveitis Characteristics and Risk of Developing Central Nervous System Inflammatory Disease: A Retrospective Cohort Study.

Ocular immunology and inflammation
2026

Rift Valley fever virus activates multiple cell death pathways in neurons.

Journal of virology
2025

Salivary cortisol in long COVID: a marker of broader stress system and circadian rhythm dysregulation.

Frontiers in cellular and infection microbiology
2025

Neurogenesis decreases in the offspring of mothers infected with influenza A virus.

Frontiers in cellular and infection microbiology
2025

Case Report: A rare pediatric case of hepatitis B virus infection with acute disseminated encephalomyelitis/Guillain-Barré syndrome spectrum diseases.

Frontiers in pediatrics
2026

Infection as a potential trigger in glial fibrillary acidic protein astrocytopathy: a case report and review of immunotherapeutic strategies.

BMC neurology
2026

Borrelia burgdorferi-Induced Neuroinflammation in Lyme Disease: A Potential Driver of Alzheimer's Disease Pathology?

Molecular neurobiology
2026

Treponema pallidum's neural invasion: from blood-brain barrier breach to immune sabotage.

Infection and immunity
2026

New-onset refractory status epilepticus associated with Sjögren's disease.

BMJ neurology open
2026

Overexpression of bank vole PrP(I109) in mice induces a spontaneous atypical prion disease with sex-dependent onset, early NfL elevation, and universal prion strain permissiveness.

Acta neuropathologica communications
2026

Anti-aging and Anti-inflammatory Dietary Interventions in Multiple Sclerosis: A Narrative Review.

Neurology and therapy
2026

Inflammation-induced Neuronal Damage in CNS Tuberculosis: Molecular Mechanism and Therapeutic Targets.

Brain research
2026

Strain Traits of Intracranially Administered L-Type Bovine Spongiform Encephalopathy Prions Are not Significantly Modified During Intraspecies Transmission in Cynomolgus Monkeys.

Microbiology and immunology
2026

Diagnosing progressive multifocal leukoencephalopathy: clinical features, neuroimaging findings, confirmatory testing and proposed diagnostic algorithm.

Practical neurology
2026

Neuron-specific overexpression of human vasoactive intestinal peptide receptor 2 in mice causes cognitive dysfunction and abnormal dendritic morphology in the prefrontal cortex.

Journal of pharmacological sciences
2026

Strongyloides stercoralis: From chronic silent infection to fulminant catastrophe.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2026

Adrenal and Metabolic Hormonal Axes Shape Anti-Tuberculosis Immune Responses in Human Immunodeficiency Virus-Tuberculosis Coinfection.

Neuroimmunomodulation
2026

Early Diagnostic Value of Contrast-Enhanced MRI in Distinguishing Toxoplasmic Encephalitis from CNS Lymphoma: A Case Report of AIDS with Seronegative Toxoplasmosis.

Journal of the International Association of Providers of AIDS Care
2026

Neuromyelitis Optica Spectrum Disorder Developing after COVID-19 Vaccination Managed with Long-Term Eculizumab Treatment: A Case Report.

Case reports in neurology
2026

Multi-Pathogen Knee Infection, Including Treponema pallidum and Brucella: A Case Report.

The American journal of case reports
2026

West Nile virus: epidemiology, prevention, clinical features, diagnosis, treatment, and open research questions.

Annals of medicine
2026

Parasitic and fungal central nervous system infections in hospitalised adults living with HIV in Libreville, Gabon: clinical profiles to inform syndromic triage in resource limited settings.

AIDS research and therapy
2026

Central nervous system complications: atypical manifestation of Lemierre syndrome.

BMC neurology
2026

Rapidly progressing idiopathic neutrophilic vasculitis with fibrinoid necrosis of the central nervous system.

BMJ case reports
2026

High Temporal-Resolution Imaging Single Immune Cell Migration in Vivo by Ultrabright NIR-II Organic Probes.

Advanced materials (Deerfield Beach, Fla.)
2026

How to Treat Carbapenem-Resistant Acinetobacter baumannii Infections: Current Knowledge and Personal Viewpoints.

Infectious disease clinics of North America
2026

Cryptococcus neoformans causing localised osteomyelitis of the right anterior rib.

BMJ case reports
2026

Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation.

Cell
2025

Habitual Coffee Consumption and Systemic Health Outcomes: A Comprehensive Review.

Cureus
2026

Compassionate Use of Olorofim for Invasive Mold Infections: A Nationwide Observational Study in France.

Open forum infectious diseases
2026

Walnut peptide and theanine combination ameliorates sleep disorders: a multi-species study including a human trial.

Food & function
2026

First detection of Usutu virus in wild birds in Denmark, 2024.

Scientific reports
2026

Elucidating the biological characteristics of overweight populations based on urine Raman spectroscopy and bioinformatics analysis.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
2026

HIV expression persists in the cerebrospinal fluid of HIV-associated neurocognitive disorders despite effective ART.

Emerging microbes & infections
2026

Japanese Encephalitis: a case of remarkable recovery after 68 days of ICU admission in a 30 -years-old-male.

BMC infectious diseases
2026

Promoting the nuclear retention of HMGB1 attenuates astrocyte senescence.

Journal of neuroinflammation
2026

Inapparent maternal ZIKV infection impacts fetal brain development and postnatal behavior.

PLoS pathogens
2026

Metabolites released from apoptotic cells in central nervous system orchestrates the pathological process of Alzheimer disease through improving autophagy.

Autophagy

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Mild SARS-CoV-2 maternal infection in mice induces transient offspring neurodevelopmental aberrance.
    Proceedings of the National Academy of Sciences of the United States of America· 2026· PMID 41849379mais citado
  2. The Anti-Apoptotic Activity of β-Synuclein Mediated via Akt Signaling Is Severely Lost During Prion Infection.
    International journal of molecular sciences· 2026· PMID 41828568mais citado
  3. HIV Infection, Neurotoxicity, Inflammation, Premature Aging, and Therapeutic Challenges to PLWH: An Overview.
    International journal of molecular sciences· 2026· PMID 41828426mais citado
  4. Alpha-Synuclein in Neurodegeneration: From Shared Biology to Disease-Specific Phenotypes.
    Cells· 2026· PMID 41827884mais citado
  5. A Novel Competing Endogenous RNA Linked to Dysregulated Neuroinflammation in Alzheimer's Disease.
    Cells· 2026· PMID 41827846mais citado
  6. T Cells Inhibit Hippocampal Regeneration in Mice Following Trimethyltin-Induced Neurodegeneration.
    Neuropathology· 2026· PMID 41853925recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:98010(Orphanet)
  2. MONDO:0020010(MONDO)
  3. Variantes catalogadas(ClinVar)
  4. Busca completa no PubMed(PubMed)
  5. Q10336461(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Doença infecciosa do sistema nervoso
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Doença infecciosa do sistema nervoso

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