Ependimona

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

Sem fase

NCT04185038

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

Fase II

NCT05278208

PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications

Fase II

NCT06161519

ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors

Sem fase

NCT04732065

NCT05057702 · Individualized Treatment Plan in Children and Young Adults W…Recrutando

🟢 Recrutando agora

11 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

NA

NCT04185038 · Study of B7-H3-Specific CAR T Cell Locoregional Immunotherap…Recrutando

NCT05278208 · Lutathera for Treatment of Recurrent or Progressive High-Gra…Recrutando

PHASE1, PHASE2

NCT06161519 · PLX038 in Primary Central Nervous System Tumors Containing M…Recrutando

PHASE1, PHASE2

NCT04732065 · ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse M…Recrutando

NCT06193759 · Immunotherapy for Malignant Pediatric Brain Tumors Employing…Recrutando

NCT01356290 · Antiangiogenic Therapy for Children With Recurrent Medullobl…Recrutando

NCT05835687 · Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pedi…Recrutando

NCT05106296 · Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patie…Recrutando

NCT04541082 · Phase I Study of Oral ONC206 in Recurrent and Rare Primary C…Recrutando

NCT05259605 · Observational Study for Assessing Treatment and Outcome of P…Recrutando

Outros ensaios clínicos

313 ensaios clínicos encontrados, 34 ativos.

Distribuição por fase

NCT02774421 · Pilot Study of the Effect of Trastuzumab and GM-CSF on Child…Ativo

NCT03155620 · Targeted Therapy Directed by Genetic Testing in Treating Ped…Ativo

NCT03213652 · Ensartinib in Treating Patients With Relapsed or Refractory …Ativo

NCT02359565 · Pembrolizumab in Treating Younger Patients With Recurrent, P…Ativo

NCT03698994 · Ulixertinib in Treating Patients With Advanced Solid Tumors,…Ativo

NCT04903080 · HER2-specific Chimeric Antigen Receptor (CAR) T Cells for Ch…Ativo

NCT03033992 · Optune for Children With High-Grade Glioma or Ependymoma, an…Ativo

NA

NCT04978727 · A Pilot Study of SurVaxM in Children Progressive or Relapsed…Ativo

NCT03210714 · Erdafitinib in Treating Patients With Relapsed or Refractory…Ativo

Ver todos no ClinicalTrials.gov

🧪 Está conduzindo uma pesquisa?

Divulgue para pacientes e familiares que acompanham esta doença.

Divulgar pesquisa →

Publicações mais relevantes

Timeline de publicações

2.349 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 2.349

#1

Multidimensional profiling of heterogeneity in supratentorial ependymomas.

Nature2026 Mar 11

Supratentorial ependymomas are aggressive childhood brain cancers that retain features of neurodevelopmental cell types1 and segregate into molecularly and clinically distinct subgroups2,3, suggesting different developmental roots. The developmental signatures, as well as microenvironmental factors, underlying aberrant cellular transformation and behaviour across each supratentorial ependymoma subgroup are unclear. Here we integrated single-cell and spatial transcriptomics, as well as in vitro and in vivo live-cell imaging, to define supratentorial ependymoma cell states, spatial organization and dynamic behaviour within the neural microenvironment. We find that individual tumour subgroups have two distinct progenitor-like cell states-neuroepithelial-like and embryonic-like-that are reminiscent of early human brain development and diverge in the extent of their neuronal or ependymal differentiation. We further identify several modes of spatial organization of these tumours, including a high-order architecture that is influenced by mesenchymal and hypoxia signatures, and local neighbourhood structures. Finally, we identify a role for brain-resident cells in shifting supratentorial ependymoma cellular heterogeneity towards neuronal-like cells that co-opt immature neuronal morphology and migratory mechanisms, and a subset of neuroepithelial-like cells that are both proliferative and highly migratory. Collectively, these findings provide a multidimensional framework to integrate transcriptional and phenotypic characterization of tumour heterogeneity in supratentorial ependymoma and its potential clinical implications.

#2

Ventriculoperitoneal shunt-associated cystic lesion with perilesional cerebral edema 45 years after placement for posterior fossa tumor: A case report.

Surgical neurology international2026

Ventriculoperitoneal (VP) shunts are widely used to treat hydrocephalus in children with posterior fossa tumors. While many patients gain shunt independence after tumor control, indwelling shunts are often not removed. Shunt-related intracranial cysts are extremely rare and typically develop along the intracranial catheter tract within days to several years after shunt insertion; to date, the longest reported interval has been 19 years. Here, we report a case a cystic lesion with marked perilesional edema developing 45 years after childhood VP shunt placement for tumor-related hydrocephalus. We report the case of a 58-year-old man who presented with acute severe left-sided hemiparesis. At the age of 13 years, he underwent resection of a posterior fossa ependymoma, VP shunt placement, and whole-brain radiotherapy. Neuroimaging revealed a large right frontal low-density lesion with vasogenic edema and a cystic cavity surrounding the intracranial shunt catheter. Retrospective review of magnetic resonance imaging performed 3 months earlier showed a smaller preexisting cyst at the same site. The shunt catheter was removed without resistance, and the membranous material adhering to the distal tip caused partial intraluminal obstruction. Postoperatively, the hemiparesis improved markedly; follow-up imaging demonstrated resolution of the edema and reduction in the cyst size. As hydrocephalus did not recur, shunt reinsertion was not required. This case represents the longest latency reported in the literature for VP shunt-related intracranial cyst formation, occurring 45 years after shunt implantation, exceeding the previously reported maximum interval of 19 years. The acute symptoms closely resemble stroke or infection, underscoring the diagnostic challenge. Clinicians should be vigilant of such delayed complications even decades after shunt placement.

#3

Modeling pediatric brain tumors with human stem cells.

Frontiers in cellular neuroscience2026

With recent advances in stem cell technology, there has been an expansion of human stem and progenitor cell models of pediatric brain tumors, including use of human pluripotent and embryonic stem cells both in organoid cultures and following xenotransplantation in mice. In this review, we discuss the current approaches to modelling pediatric brain cancers using stem cells. While brain tumors describe a broad set of disease entities, we focus on glioma, medulloblastoma and ependymoma, as these are not only the most common malignant brain tumor types but also have the most stem cell models currently available. We examine human stem cell-based modeling approaches and discuss the biological questions that are being addressed using these state-of-the-art tools. Specifically, we focus on the unique advantage of using these cells to understand the functional consequences of gene mutations and their downstream growth-promoting pathways within the cell in a human context. These approaches are needed to ascertain the key players that are functionally relevant in the initiation and propagation of these tumors at the gene and protein level and to identify new drug targets. Moreover, human stem cell-based modeling approaches may complement studies in genetically engineered mouse models to address fundamental questions in tumor biology, particularly the early stages of tumorigenesis.

#4

A systems approach identifies MERTK as a therapeutic vulnerability in ZFTA-RELA-driven ependymomas.

Proceedings of the National Academy of Sciences of the United States of America2026 Feb 17

Ependymomas (EPN) are rare central nervous system tumors that account for approximately 10% of intracranial tumors in children and 4% in adults. Despite their clinical and molecular heterogeneity, spanning supratentorial, posterior fossa, and spinal subtypes, treatment remains limited to surgery and radiotherapy, with chemotherapy offering minimal benefit. Here, we performed transcriptomic analysis of 370 human ependymoma samples and identified two distinct molecular subgroups: EPN-E1 and EPN-E2. The EPN-E1 cluster is enriched for supratentorial tumors harboring ZFTA-RELA fusions (ZFTA-RELAfus), which occur in over 70% of cases and are associated with poor prognosis. To identify targeted therapies for this aggressive subtype, we validated a ZFTA-RELAfus mouse model that recapitulates the human EPN-E1 transcriptome and used it for target discovery. Through Kinome Regularization, a machine learning-driven polypharmacology approach, we identified MERTK as a critical regulator of tumor cell viability. Genetic depletion or pharmacologic inhibition of Mertk reduced cell growth ex vivo, and treatment with a clinical-grade MERTK inhibitor significantly suppressed tumor proliferation in vivo. Both human EPN-E1 tumors and ZFTA-RELAfus mouse tumors exhibited elevated expression of MERTK and its ligand GAS6, and MERTK inhibition led to suppression of pro-survival signaling pathways including MEK/ERK (Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase) and PI3K/AKT (Phosphoinositide 3-Kinase/Protein Kinase B). Notably, over 80% of genes upregulated in ZFTA-RELAfus tumors were downregulated following MERTK inhibition, indicating a strong dependency on this pathway for tumor maintenance. These findings define a signaling vulnerability in ZFTA-RELA-driven ependymomas and support the clinical development of MERTK-targeted therapies for patients with the high-risk EPN-E1 subtype.

#5

Thoracic tanycytic ependymoma with anaplastic progression after subtotal resection and repeated radiotherapy: A 17-year follow-up case report.

Surgical neurology international2026

Tanycytic ependymomas (TEs) are rare spindle-cell variants of spinal ependymomas. They are classified as central nervous system World Health Organization grade II, and they usually behave like ordinary spinal ependymomas especially following gross total resection (GTR). A 43-year-old male presented with a progressive paraparesis and sensory level at T4 (pain/ temperature loss). The magnetic resonance imaging showed an intradural intramedullary tumor extending from Th2 to Th5. Only a subtotal resection was performed as a central portion was tightly adherent to the spinal cord itself. Histology revealed a predominantly grade II TE; the main component showed a low proliferative index, whereas the anaplastic focus had a markedly elevated index. Despite craniospinal tomotherapy (36 Gy), tumor recurred 6 years 7 months later. Local tomotherapy was repeated 3 times (41.4, 40, and 30 Gy), but each treatment produced only transient shrinkage followed by regrowth at shorter intervals. Further irradiation was contraindicated due to cumulative dose constraints. Seventeen years after the first surgery, rapid enlargement over 3 months caused paraplegia and bladder-bowel dysfunction. Reoperation achieved GTR, and at this point the pathology showed a diffuse anaplastic ependymoma; the MR 6 months later showed no tumor recurrence. Although TE is usually indolent, it can harbor an anaplastic subclone and progress to malignancy after subtotal resection. Long-term surveillance and early reoperation when regrowth is first observed should be considered and is likely due to the development of anaplastic features.

Publicações recentes

Intracranial ependymoma grade II with lipomatous metaplasia: a case report and literature review.

Front Oncol2026

Clinical Characteristics, Management, and Outcomes of Intramedullary Spinal Cord Ependymomas: A Systematic Review and Meta-Analysis.

Spine Surg Relat Res2026 Mar 27

Clinical and Magnetic Resonance Features of Spinal Myxopapillary Ependymoma.

Neurosurg Pract2026 Jun

CNS tumor type prevalence according to age group: an analysis of 21,000 cases confirmed by methylation profiling, with a focus on adolescents and young adults.

Neuro Oncol2026 Apr 13

Ependymoma group-specific blood-brain barrier differences uncovered by a multi-omics approach.

Sci Rep2026 Apr 10

Ver todas no PubMed

📚 EuropePMC2.727 artigos no totalmostrando 198

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

Reverse brain herniation following CSF diversion in a 2-year-old child-case report and review of literature.

Discovery of genetic susceptibility variants in pediatric and adult ependymoma.

Neuro-oncology advances

Journal of the Formosan Medical Association = Taiwan yi zhi

Development and internal validation of a Cox-based nomogram for predicting cancer-specific survival in central nervous system ependymoma: a population-based study.

Is maternal smoking during pregnancy associated with childhood brain tumors? A systematic literature review.

Toxicology letters

Case Report: Molecular diagnostics and clinical courses of two adult spinal pilocytic astrocytoma long-term survivors with GTF2I::BRAF fusion.

Nivolumab-Associated Autoimmune Encephalopathy in a Child With Multiply Relapsed Anaplastic Ependymoma.

AI-driven label-free Raman spectromics for intraoperative spinal tumor assessment.

NPJ digital medicine

The Hastings Center report

A Parental Request for an Unproven Treatment for a Rare Pediatric Cancer: Sound Reasons for Not Going Off-Label.

The Hastings Center report

The Case for Prescribing Metformin Off-Label for a Child in Remission from Ependymoma.

Phase I/II Study of the CDK2/9 Inhibitor Fadraciclib in Combination with Chemotherapy in Children with Advanced Malignancies: Arm K of the AcSé-ESMART Trial.

Targeted oncology

International journal of surgery case reports

Thoracic intramedullary spinal cord astrocytoma associated with syringomyelia: a case report of gross total resection.

Neuroendocrine Tumor of the Cauda Equina: A Report of a Rare Case With Histopathological and Immunohistochemical Correlation.

Exploiting Metabolic Dependencies for Therapeutic Targeting of Brain Cancers.

Cancer letters

Metabolic vulnerability in fusion-driven ependymoma.

Nature reviews. Cancer

Multidimensional profiling of heterogeneity in supratentorial ependymomas.

Nature

Back to square one: Treatment for ependymoma in the post-ACNS0831 era.

The American journal of surgical pathology

Adnexal Endometrioid Carcinomas With Sex Cord-Like Morphology are Frequently PAX8-Negative, SOX17-Positive, and Enriched for CTNNB1 Alterations.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Effect of radiation on patients with grade 2 intramedullary spine ependymoma.

Targeted and systemic therapies for recurrent adult ependymomas: real-world outcomes from a single institution and concise literature review.

Anterior Fibular Graft and Posterior Fusion for Proximal Cervical Kyphosis Following Resection of Posterior Fossa Ependymoma: A Case Report.

JBJS case connector

Ventriculoperitoneal shunt-associated cystic lesion with perilesional cerebral edema 45 years after placement for posterior fossa tumor: A case report.

Archives of Iranian medicine

Primary Pediatric Brain Tumors in a Tertiary Referral Center in Iran: A 13-Year Retrospective Analysis.

Frontiers in cellular neuroscience

Modeling pediatric brain tumors with human stem cells.

Restricting Itaconate Suppresses ZFTA-RELA Ependymoma Growth.

Cancer discovery

Critical reviews in oncology/hematology

Proton Radiotherapy Outcomes in Pediatric Ependymoma: a Long-term meta-analysis (PROPEL).

Nuances in the management of cerebellopontine angle ependymomas: illustrative case.

The Impact of Hearing Loss on Cognitive Outcomes among Children Treated with Radiation Therapy for Ependymoma.

The Journal of clinical endocrinology and metabolism

"Endocrine Disorders After Treatment for Pediatric Brain Tumors: Long-Term Outcomes and Risk Factors".

Annals of medicine and surgery (2012)

A rare constellation of bilateral progressive visual and auditory loss in neurofibromatosis type 2: a multimodal diagnostic approach.

Memantine to preserve memory and neurocognition following craniospinal irradiation (MEMENTO): a phase 3 randomized controlled trial.

BMC cancer

Proceedings of the National Academy of Sciences of the United States of America

A systems approach identifies MERTK as a therapeutic vulnerability in ZFTA-RELA-driven ependymomas.

Thoracic tanycytic ependymoma with anaplastic progression after subtotal resection and repeated radiotherapy: A 17-year follow-up case report.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

Accurate classification of ependymomas and medulloblastomas using Raman spectroscopy and pilot transcriptomic profiling.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

Clinical predictors of overall survival in pediatric patients with intramedullary spinal tumors: an analysis of the SEER database.

Acta neuropathologica communications

Two pediatric supratentorial ependymal tumors with novel PLAG1 fusions.

Childhood brain tumors instruct cranial hematopoiesis and immunotolerance.

Nature genetics

British journal of neurosurgery

En-bloc resection achieves higher GTR rates with similar neurological outcomes in grade-2 intramedullary spinal ependymomas: single-centre cohort study.

Biochemical and biophysical research communications

Unraveling the miRNA-EMT-stemness interplay in fusion-positive supratentorial ependymomas: Identifying therapeutic vulnerabilities.

A brief history of ependymoma.

Surgical treatment of myxopapillary ependymoma: an institutional case series of 56 patients.

Frontiers in reproductive health

An opportunity for fertility preservation in neurosurgical spinal ependymoma patients: a single center review.

International journal of molecular sciences

EZHIP in Pediatric Brain Tumors: From Epigenetic Mimicry to Therapeutic Vulnerabilities.

World journal of pediatric surgery

Thoracic metastasis of a pediatric posterior fossa group A ependymoma: a rare case and literature review.

Radiological analysis correlated with neurological outcomes following resection of myxopapillary ependymoma: patient series.

Recurrent pediatric posterior fossa anaplastic ependymoma managed with multiple resections: illustrative case.

Posterior fossa ependymoma harboring H3K27M mutation: A rare case report with clinical follow-up and diagnostic challenges.

Clinical neuropathology

Intraoperative Ultrasound Imaging Features Guiding Surgical Strategy in Spinal Cord Ependymoma Resection.

Neurosurgery practice

Brain pathology (Zurich, Switzerland)

A highly abundant circular RNA from the RMST locus plays a role in posterior fossa ependymoma pathogenesis.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

Spinal deformity following surgery for paediatric intramedullary spinal cord tumours.

Clinical and Prognostic Implications of Isocitrate Dehydrogenase Mutation in Gliomas Within a Latin American Public Oncology System: Insights From a Retrospective Panamanian Cohort.

International journal of surgery case reports

Extraspinal sacrococcygeal anaplastic ependymoma: A case report.

Operative neurosurgery (Hagerstown, Md.)

Brain Mapping for Surgical Resection of Left Dominant Supramarginal and Angular Gyrus Grade II Ependymoma: 2-Dimensional Operative Video.

Multimodal-based analysis of single-cell ATAC-seq data enables highly accurate delineation of clinically relevant tumor cell subpopulations.

Genome medicine

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

Impact of molecular subtypes on postoperative hydrocephalus following resection of posterior fossa medulloblastoma and ependymoma in children: A systematic review and meta-analysis.

Brain pathology (Zurich, Switzerland)

RE: Comments on cIMPACT-NOW Update 11.

Pakistan journal of medical sciences

A rare case of supratentorial intraparenchymal ependymoma in a 13 years old girl: Diagnostic and therapeutic challenges.

A Systematic Review of Evidence on the Clinical Effectiveness of Surveillance Imaging in Children With Medulloblastoma and Ependymoma.

Diagnostics (Basel, Switzerland)

Cerebello-Pontine Angle Tumors in Children: An Update on Challenging Neoplasms.

International journal of particle therapy

Proton-Based Re-Irradiation of Locally Recurrent Pediatric Brain Tumors in Close Proximity to the Brainstem.

Methylation profiling in neuropathological tumors diagnosis: a comprehensive review.

Diagnostics (Basel, Switzerland)

Histopathological Assessment of Cellular Heterogeneity in Pediatric Ependymomas.

Journal of Korean Neurosurgical Society

Clinical Features and Prognostic Indicators for Brainstem Ependymomas : A Population-Based Retrospective Surveillance, Epidemiology, and End Results Database Analysis.

Phase 1 study of mebendazole therapy for refractory/progressive or recurrent pediatric brain tumors.

Neuro-oncology practice

Journal of neuropathology and experimental neurology

Longitudinal neuropathologic and molecular characterization of a retroperitoneal ependymoma.

Phase 3 randomized trial of post-irradiation chemotherapy in patients with newly diagnosed ependymoma, a report from the Children's Oncology Group.

Neuropathology : official journal of the Japanese Society of Neuropathology

Posterior Fossa Group A Ependymoma in Trisomy 21.

Surgery in NF2-Schwannomatosis.

Familial cancer

Algorithm-based assessment of T-cell dysfunction and exclusion to forecast ICB sensitivity in pediatric brain ependymoma.

A rare case of cauda equina paraganglioma histologically simulating ependymoma.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Outcomes of initially chosen non-operative management for spinal ependymoma.

Epidemiologia e prevenzione

Benchmarking nazionale della sopravvivenza per stadio alla diagnosi dei tumori infantili in Italia (BENCHISTA-ITA): protocollo di studio.

Indian journal of orthopaedics

Multifocal Spinal Intradural Myxopapillary Ependymoma.

Intraspinal collision tumor comprising a schwannoma and ependymocytoma: a rare case study and literature review.

Folia neuropathologica

No shinkei geka. Neurological surgery

[Fertility Preservation for Pediatric Brain Tumor Patients: Current Status and Challenges].

No shinkei geka. Neurological surgery

[Current Status and Prospects of Clinical Trials for Ependymoma].

Clinical and Magnetic Resonance Findings for the Diagnosis of Recurrent Tumors versus Radiation-Induced Secondary Tumors of Malignant Pediatric Brain Tumors of the Posterior Fossa.

World neurosurgery

Ascending Transtentorial Herniation: A Rare Complication of Posterior Cranial Fossa Tumors and Review of Literature.

Utility of Immunohistochemistry in Subtyping Posterior Fossa Group A Ependymoma: A Retrospective Study.

Non-invasive prediction of Ki-67 and p53 biomarkers in spinal ependymoma via deep learning: using multimodal magnetic resonance imaging and clinical data.

Biomarker research

Development and validation of a multi-modal MRI-based deep learning framework for differentiation of intraspinal tumors (ISMF-Net).

EClinicalMedicine

Precise diagnosis of pediatric posterior cranial fossa neoplasms based on 2.5D MRI deep learning.

Syncope in a Patient With an Extensive Thoracolumbosacral Myxopapillary Ependymoma.

Late Morbidity and Mortality in Survivors of Childhood Ependymoma: A Report from the Childhood Cancer Survivor Study (CCSS).

Cancers

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Patterns of care in primary brain tumour Reirradiation: A survey by the ESTRO CNS focus Group.

The Journal of clinical investigation

CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma models.

The clinical spectrum of paediatric NF2- related schwannomatosis.

Familial cancer

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

DNA Methylation Profiling Classifies and Reveals Origin of Gynecologic Central Nervous System-Like Tumors.

bioRxiv : the preprint server for biology

Pan-cancer 3D genomic analysis revealed extremely long Polycomb loops as the biomarker for sensitivity to Polycomb inhibition.

A rare case of supratentorial ependymosarcoma harboring ZFTA::RELA fusion.

Brain tumor pathology

Single-nucleus transcriptomics of spinal ependymoma subtypes recognizes intratumoral heterogeneity.

bioRxiv : the preprint server for biology

Matrix viscoelasticity regulates dendritic cell migration and immune priming.

Tumor size and treatment factors as correlates of 10-year mortality in grade III spinal ependymomas: a nationwide analysis.

Fatal ornithine transcarbamylase deficiency presentation postresection of fourth ventricle ependymoma: illustrative case.

Maternal Neurosurgical Management of Central Nervous System Tumors During Pregnancy: A Case Series with Long-Term Offspring Neurodevelopmental Follow-Up.

World neurosurgery

Acta neuropathologica communications

EZHIP boosts neuronal-like synaptic gene programs and depresses polyamine metabolism.

Advances in cancer research

Three decades of radiotherapy advancements for pediatric ependymoma.

Adult ependymoma: results from the Dutch Brain Tumour Registry on primary treatment and survival.

The current status of immune checkpoint inhibitors in pediatric CNS tumors: a systematic review with a representative case of CMMRD-associated glioma.

Cellular oncology (Dordrecht, Netherlands)

Multi-omics analysis delineates molecular signatures of spinal ependymal tumor.

Integrated transcriptomic landscape of medulloblastoma and ependymoma reveals novel tumor subtype-specific biology.

Journal of clinical medicine

Tandem Detethering: A Novel One-Stage Approach Combining Cervicothoracic Cord Release Followed by Filum Terminale Sectioning.

Genetic Markers and Mutations in Primary Spinal Cord Tumors and Their Impact on Clinical Management.

Brain sciences

Integrated Single-Nucleus and Spatial Transcriptomics Elucidate Heterogeneity and Hypoxia-Driven Organization of Supratentorial Ependymoma.

Cancer research

Technical innovations & patient support in radiation oncology

Three-year insights from a proton therapy centre: Evolving strategies in ependymoma treatment planning.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

Clinical profile and outcomes of pediatric ependymoma: a 10-year retrospective analysis from a resource-limited setting.

Presenting symptoms and outcomes of cervical and thoracic ependymomas compared to conus and filum ependymomas.

Intraoperative neurophysiological monitoring in surgery for intramedullary spinal cord lesions - workflow, setup and outcomes.

Acta neurochirurgica

A predictive model for differentiating PFA and PFB subtypes of posterior fossa ependymoma using multi-sequence MRI radiomics: a two-center study.

Neuroradiology

Current neurology and neuroscience reports

Ependymoma: Advances in Systems Treatment Strategies.

The Pan African medical journal

High-grade astroblastoma initially misdiagnosed as papillary meningioma: a case report.

Profiling extracellular vesicles from cerebrospinal fluid for classification of intradural spinal tumors.

Spinal myxopapillary ependymoma with anaplastic features: A case report and review of the literature.

British journal of neurosurgery

Laparoscopic anchoring of peritoneal catheters using surgical mesh - a promising approach for recurrent extrinsic ventriculoperitoneal shunt migration.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

The effect of oncolytic virotherapy on pediatric brain tumor- a systematic review.

The Role of D-Wave Monitoring in Motor-Evoked Potential Loss During Intramedullary Spinal Cord Tumors Resection.

Neurospine

Zhongguo gu shang = China journal of orthopaedics and traumatology

[Intramedullary ependymoma of spinal canal:a case report].

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Investigation of DNA Damage Response Genes Validates the Role of DNA Repair in Pediatric Cancer Risk and Identifies SMARCAL1 as a Novel Osteosarcoma Predisposition Gene.

Acta medica (Hradec Kralove)

EUS Guided FNA Cell Block Cytology and Intraoperative Squash Cytology in the Diagnostic Approach of Unfamiliar Malignant Neoplastic Disorders.

Medical archives (Sarajevo, Bosnia and Herzegovina)

Surgical Outcomes and Prognostic Factors for Resectability of Intramedullary Spinal Cord Tumors Incorporating Intraoperative Neurophysiological Monitoring In Vietnam.

Surgical technique for executing an en bloc resection of a multilevel cervical intramedullary ependymoma: A 2D operative video.

Journal of surgical case reports

A rare case of posterior fossa collision tumor involving low-grade astrocytoma and meningioma.

Developing an advanced risk stratification model for pediatric intracranial ependymoma based on the prospective trial E-HIT2000 and subsequent registries.

Journal of neuropathology and experimental neurology

Aqueductal posterior fossa type B ependymoma in Li-Fraumeni syndrome.

Intramedullary Schwannoma of the Conus Medullaris Presenting With Progressive Paraparesis: A Rare Case From a Resource-Limited Setting.

Clinical case reports

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

Delay in the diagnosis of pediatric central nervous system tumors: data from a single tertiary care center.

AJNR. American journal of neuroradiology

Imaging Differentiation of Supratentorial Ependymoma and High-Grade Glioma in Children Using VASARI Features.

Conditionally Reprogrammed Cells as Preclinical Model for Rare Cancers.

Cancers

Human Polyomavirus BK Genome Analysis in BKPyV Induced Rodent Cell Lines.

MicrobiologyOpen

Journal of pathology and translational medicine

Central nervous system tumors with BCOR internal tandem duplications: a systematic review of clinical, radiological, and pathological features in 69 cases.

Current Approach and Predictors of Clinical Outcomes in Adults With Spinal Ependymomas.

Brain pathology (Zurich, Switzerland)

cIMPACT-NOW update 11: Proposal on adaptation of diagnostic criteria for IDH- and H3-wildtype diffuse high-grade gliomas and for posterior fossa ependymal tumors.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

Impact of the COVID-19 pandemic on diagnosis and management of new brain tumours in children and young people (aged < 16 years old) in the UK.

Medical sciences (Basel, Switzerland)

Survival Patterns and Mortality Causes in Patients with Invasive Ependymoma: A Retrospective Cohort Analysis from 2000 to 2019.

Microscopic Minimal Invasive Resection of Spinal Tumor with Tubular Retractor System: Case Studies of 70 Patients with Literature Review.

Microscopic Resection of Intracranial Lesions with Tubular Retractor of Plastic Syringe: A Single-Center Experience of 157 Cases.

Multicenter basket trial for central nervous system tumors identifies activity of the CDK4/6 inhibitor abemaciclib in recurrent meningioma.

Radiomics in pediatric brain tumors: from images to insights.

Discover oncology

Neurologia medico-chirurgica

Nationwide Brain Tumor Registry-based Study of Adult Intracranial Ependymoma in Japan.

Recent patents on anti-cancer drug discovery

Targeted Therapy with Dalpiciclib in a Pediatric Patient with Anaplastic Ependymoma: A Case Study and Literature Review.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Microsurgical removal of a C1-C5 laterally located intramedullary subependymoma through a postero-lateral sulcus approach: case report, surgical video and critical review of diagnostic and surgical challenges.

Current neurology and neuroscience reports

Central Nervous System Tumors in Adolescents and Young Adults.

How is rosette formation in brain tumours linked with cerebrospinal fluid spread?

Brain tumor pathology

Intracranial low-grade tumors with ALK rearrangement: diverse tumor types with shared molecular alterations.

Human pathology

Spinal Myxopapillary Ependymoma Presenting With Isolated Intracranial Hypertension: A Case Report.

An anaplastic ependymoma with chondroid metaplasia after stereotactic radiosurgery: illustrative case.

Effect of the TGF-b signaling pathway on spinal cord ependymoma: A study based on bioinformatics analysis and clinical trials.

Folia neuropathologica

PLAG1 fusions define a third subtype of CNS embryonal tumor with PLAG family gene alteration.

Acta neuropathologica

Building a dynamic web calculator for individualized conditional survival estimation in brainstem ependymoma.

Neuropathology : official journal of the Japanese Society of Neuropathology

Metastatic Supratentorial Ependymoma: A Case Presentation and Systematic Review of the Literature.

International journal of molecular sciences

CNS Tumor with BCOR/BCORL1 Fusion: A Rare Tumor Entity.

International journal of general medicine

Correlation Analysis of Imaging and Pathological Features of Ependymomas.

Uncharted Territory: The First Case of Cardiac Myxoma in a Patient With NF2.

JACC. Case reports

Different nuances between patient- and surgeon-reported outcomes in intramedullary ependymoma surgery.

Freiburg Neuropathology Case Conference: Transition from Chronic Dizziness to Acute Headache and Nausea in a 30-Year-Old.

Clinical neuroradiology

Syringobulbia and Syringomyelia Associated with Intramedullary Ependymoma.

World neurosurgery

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

Practice Pearls: Spinal Myxopapillary Ependymoma Masquerading as Charcot-Marie Tooth (CMT) Disease.

Extraventricular Neurocytoma With a Complex Presentation: The Role of Molecular Studies and Technology in Its Management.

The role of MRI patterns in predicting neurologic deficits in spinal ependymomas.

Acute paraplegia following epidural anesthesia for cesarean delivery due to asymptomatic spinal cord ependymoma hemorrhage: A case report and literature review.

Medicine

JNMA; journal of the Nepal Medical Association

Long-level Intramedullary Spinal Cord Tumor: A Case Series.

Journal of clinical medicine

Histopathological Types, Clinical Presentation, Imaging Studies, Treatment Strategies, and Prognosis of Posterior Pituitary Tumors: An Updated Review.

Survival and Functional Outcomes Following Surgical Resection of Intramedullary Spinal Cord Tumors: A Series of 253 Patients over 22 Years.

Cancers

Are dorsal column deficits inevitable in intramedullary spine tumor resection?

Journal of neurosurgery. Pediatrics

Primary pediatric brain tumors in Africa: a systematic review and comparative meta-analysis.

Journal of pediatric hematology/oncology

Adjuvant Etoposide for Very High-risk PFA Ependymoma: A Case Report.

Clinical cancer research : an official journal of the American Association for Cancer Research

B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response.

Myxopapillary Ependymoma: A Case Report.

Chinese clinical oncology

Pulsed reduced dose rate radiotherapy: a narrative review.

Pseudoprogression in Pediatric Spinal Pilocytic Astrocytoma and Myxopapillary Ependymoma after Proton Therapy: A Case Series.

Optimizing outcomes in intracranial ependymoma: a contemporary review.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Machine learning-driven national analysis for predicting adverse outcomes in intramedullary spinal cord tumor surgery.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Radiosurgery for pediatric central nervous system lesions - initial report and insights from a multicenter registry.

Recurrent parietal lobe supratentorial ependymoma, ZFTA fusion-positive, CNS WHO grade 3, with new dural and calvarial reactive changes in a child: illustrative case.

International journal of cancer

How long should survivors of pediatric medulloblastoma and ependymoma be screened for recurrence? A retrospective cohort study.

Intramedullary schwannoma mimicking ependymoma: illustrative case.

Comprehensive Genome Analysis Facilitates the Diagnosis of Ependymoma With ZFTA::NCOA2 Fusion.

Iranian journal of child neurology

Diagnostic Accuracy of MRI and CT Scan Features in Differentiation of Pediatric Ependymoma from Medulloblastoma.

Clinical oncology (Royal College of Radiologists (Great Britain))

Assessment of Clinical and Neurological Alterations Before Radiation Therapy in Children With Malignant Brain Tumours.

Extra-neural metastases of recurrent myxopapillary ependymoma: A patient case and literature review.

Neuropathology : official journal of the Japanese Society of Neuropathology

Non-Neoplastic Lesions of the Ependyma: A Neuropathological Overview.

Neurologia medico-chirurgica

Dynamic Magnetic Resonance Imaging Changes in Spinal Ependymomas and Their Impact on Surgical Planning.

An adult patient with initial presentation of myxopapillary ependymoma at the cerebellopontine angle: illustrative case.

How many cases of spinal intramedullary ependymoma surgery are required to achieve stability? - Analysis using X-bar charts.

Spinal cord

International journal of surgery case reports

Supra-sellar clear cell ependymoma in a 2-year-old female: A case report.

Radiosurgery for central nervous system ependymomas: a systematic review and meta-analysis.

Journal of human hypertension

Multiple system biology approaches reveals the role of the hsa-miR-21 in increasing risk of neurological disorders in patients suffering from hypertension.

Journal of visualized experiments : JoVE

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device.

The immunopeptidomic landscape of ependymomas provides actionable antigens for T-cell-based immunotherapy.

Neuro-oncology advances

Freiburg Neuropathology Case Conference: Gait Ataxia, Segmental Hypoesthesia, and Combined Incontinence in a 57-Years-Old Patient.

Clinical neuroradiology

Frontiers in molecular biosciences

MRI-based deep learning with clinical and imaging features to differentiate medulloblastoma and ependymoma in children.

Acta oncologica (Stockholm, Sweden)

Dosimetric comparison of intensity-modulated proton therapy and proton arc therapy for pediatric ependymoma.

Acta neuropathologica communications

Expanding clinicopathologic knowledge in high-grade glioma with pleomorphic and pseudopapillary features (HPAP): a report of two cases.

Three cases of pituicytoma with a review of the literature and insight into a rare variant of ependymal pituicytoma.

Clinical neuropathology

Clinical Characteristics, Histopathological Profile, and Postoperative Outcomes of Tumoral Radiculomedullary Compressions.

Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressure.

Cell reports. Medicine

Operative neurosurgery (Hagerstown, Md.)

Resection of a Cerebellopontine Angle Ependymoma Using a Far Lateral Approach: 2-Dimensional Operative Video.

Magnetic resonance imaging (MRI) radiomics in paediatric neuro-oncology: A systematic review of clinical applications, feature interpretation, and biological insights in the characterisation and management of childhood brain tumours.

Digital health

Automatic smart brain tumor classification and prediction system using deep learning.