Raras
Buscar doenças, sintomas, genes...
Insuficiência suprarrenal aguda
ORPHA:95409CID-10 · E27.2CID-11 · 5A74.1PCDT · SUSDOENÇA RARA

Insuficiência adrenal primária causada por uma produção súbita e defeituosa de esteróides adrenais (cortisol e aldosterona). Representa uma emergência, portanto o rápido reconhecimento e a pronta terapia são fundamentais para a sobrevivência antes mesmo do diagnóstico ser feito.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

Insuficiência adrenal primária causada por uma produção súbita e defeituosa de esteróides adrenais (cortisol e aldosterona). Representa uma emergência, portanto o rápido reconhecimento e a pronta terapia são fundamentais para a sobrevivência antes mesmo do diagnóstico ser feito.

Publicações científicas
455 artigos
Último publicado: 2026 Apr 14

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
All ages
🏥
SUS: Cobertura mínimaScore: 30%
PCDT disponívelCID-10: E27.2
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🫘
Rins
5 sintomas
📏
Crescimento
5 sintomas
🫃
Digestivo
4 sintomas
🧬
Pele e cabelo
3 sintomas
🧠
Neurológico
2 sintomas
❤️
Coração
1 sintomas

+ 21 sintomas em outras categorias

Características mais comuns

100%prev.
Insuficiência adrenal primária
100%prev.
Nível diminuído de cortisol circulante
90%prev.
Hipotensão
Muito frequente (99-80%)
90%prev.
Hiperpigmentação da pele
Muito frequente (99-80%)
90%prev.
Déficit de crescimento
Muito frequente (99-80%)
90%prev.
Perda de peso
Muito frequente (99-80%)
45sintomas
Muito frequente (16)
Frequente (16)
Ocasional (12)
Sem dados (1)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 45 características clínicas mais associadas, ordenadas por frequência.

Insuficiência adrenal primáriaPrimary adrenal insufficiency
Muito frequente100%
Nível diminuído de cortisol circulanteDecreased circulating cortisol level
Muito frequente100%
HipotensãoHypotension
Muito frequente (99-80%)90%
Hiperpigmentação da peleHyperpigmentation of the skin
Muito frequente (99-80%)90%
Déficit de crescimentoFailure to thrive
Muito frequente (99-80%)90%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico455PubMed
Últimos 10 anos127publicações
Pico202220 papers
Linha do tempo
2026Hoje · 2026🧪 2002Primeiro ensaio clínico📈 2022Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
Aprovado1
2Fase 21
1Fase 11
·Pré-clínico7
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 10 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Insuficiência suprarrenal aguda

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Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

10 ensaios clínicos encontrados.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
134 papers (10 anos)
#1

Beyond Neutropenic Fever: Severe Multiorgan Immune-Related Toxicity Induced by Pembrolizumab.

Cureus2026 Jan

The use of immune checkpoint inhibitors (ICIs) has revolutionized cancer therapy, introducing a new spectrum of oncologic emergencies associated with immune-related toxicities, which are sometimes severe and difficult to recognize. We report the case of a 49-year-old woman with early-stage triple-negative breast cancer undergoing neoadjuvant chemotherapy with carboplatin, paclitaxel, and pembrolizumab, who presented to the emergency department with abdominal pain, diarrhea, nausea, and vomiting. On admission, she was in shock, with pancytopenia, acute kidney injury, hyponatremia, and low serum cortisol levels. After exclusion of infectious causes, she was diagnosed with pembrolizumab-induced multiorgan immune-related toxicity, manifesting as acute adrenal insufficiency with shock (grade 3), colitis (grade 3), pancytopenia (grade 3), and hypothyroidism (grade 2). Treatment with methylprednisolone 500 mg/day for three days, followed by tapering, filgrastim, and levothyroxine adjustment, led to rapid clinical and laboratory improvement. Pembrolizumab was permanently discontinued. This case highlights the importance of early recognition and aggressive management of potentially fatal immune-related toxicities associated with ICIs.

#2

A case of the endoscopic removal of a gastric bezoar made of sodium zirconium cyclosilicate hydrate.

Internal medicine (Tokyo, Japan)2026 Jan 15

Sodium zirconium cyclosilicate hydrate (SZC) is a novel potassium binder that can be administered either orally or via nasogastric tubes. We report the case of a 77-year-old woman who developed a 37-mm gastric bezoar after nasogastric SZC administration during intensive care for acute adrenal insufficiency. Endoscopic removal was performed, and the analysis confirmed that the SZC was the primary constituent. Impaired gastric motility, acidic gastric environment, and limited hydration are likely contributors. This case highlights the potential for SZC-induced gastric bezoar formation in critically ill patients, and underscores the importance of imaging monitoring, careful gastrointestinal management, and the awareness of this potential complication during SZC therapy.

#3

Acute adrenal insufficiency-induced hypotension following spinal surgery in a pediatric patient with Charcot-Marie-Tooth disease and severe scoliosis: a case report.

BMC pediatrics2025 Jul 11

Acute adrenocortical insufficiency (adrenal crisis) as a cause of postoperative hypotension is an uncommon and underreported condition in pediatric patients. Charcot-Marie-Tooth (CMT) disease, a hereditary motor and sensory neuropathy, frequently coexists with scoliosis. Surgical correction of severe scoliosis involves significant stress due to considerable surgical trauma and prolonged operative time. A 13-year-old female diagnosed with CMT and severe scoliosis (thoracic curvature Cobb angle 92°) underwent posterior osteotomy and corrective surgery. On postoperative Day 1, the patient experienced persistent hypotension (systolic blood pressure < 90 mmHg) that did not respond to fluid resuscitation or vasopressor support with dopamine. On postoperative Day 4, Adrenocorticotropic Hormone (ACTH) stimulation testing revealed a cortisol level of 323.1 nmol/L which was low in the context of physiological stress, along with a markedly reduced ACTH concentration of 4.72 pg/ml, confirming a diagnosis of acute adrenocortical insufficiency. Hydrocortisone treatment resulted in a gradual normalization of blood pressure, which returned to preoperative levels by postoperative Day 8. Steroid therapy was discontinued following normalization of adrenal hormone levels. In pediatric patients undergoing surgery for severe scoliosis, unexplained postoperative hypotension warrants thorough evaluation for adrenal crisis, especially in the context of underlying chronic illness or malnutrition.

#4

Case Report: Type II Bartter syndrome with a novel KCNJ1 variant in a premature neonate presenting with features of salt-wasting congenital adrenal crisis and pseudo-hypoaldosteronism.

Frontiers in pediatrics2025

Bartter syndrome (BS) is a rare group of inherited renal tubulopathies. Diagnosis of BS type II is challenging in the neonatal period as its clinical findings and biochemical features may mimic that of adrenal crisis and pseudo-hypoaldosteronism (PHA) initially. Treatment should be instituted immediately for acute adrenal insufficiency as it is a medical emergency, then modified according to available investigation results and treatment response. We describe a premature female neonate with an antenatal history of severe unexplained polyhydramnios, presented with features of adrenal crisis managed with hydrocortisone and fludrocortisone. Initial endocrine investigations excluded salt-wasting congenital adrenal hyperplasia (SW-CAH) and pointed to the diagnosis of PHA with hyperreninemic hyperaldosteronism. Hydrocortisone was gradually weaned off while fludrocortisone was continued for sodium retention effect. Hyperkalemia quickly transited into hypokalemia requiring high potassium requirement. Clinical and biochemical features of BS gradually evolved with polyuria, excessive weight loss, hypochloremic metabolic alkalosis and hypercalciuria at 1 week of age. Urgent trio whole exome sequencing (WES) subsequently confirmed the diagnosis of BS type II where compound heterozygous missense variants were identified in the KCNJ1 gene, one of which was a novel variant. Fludrocortisone was stopped and indomethacin was started with favorable outcomes. Though hypokalemia is the key feature of BS, transient hyperkalemia can occur in the early neonatal period in BS type II. Antenatal history should be enquired thoroughly to look for presence of severe unexplained polyhydramnios. The diagnosis of BS type II should be considered if other biochemical features are present. Genetic tests are important to provide a definite diagnosis and guide subsequent management and genetic counselling.

#5

Bilateral Adrenal Hemorrhage and Acute Adrenal Insufficiency Secondary to Heparin-Induced Thrombocytopenia After Coronary Artery Bypass Graft Surgery.

AACE endocrinology and diabetes2025

Adrenal insufficiency (AI) secondary to bilateral adrenal hemorrhage (BAH) from heparin-induced thrombocytopenia (HIT) is rare; only 3 instances of such cases were reported after coronary artery bypass graft surgery (CABG). We report a case of AI due to BAH from HIT after an elective CABG. A 56-year-old male with a history of diabetes and multivessel coronary artery disease underwent CABG a week ago presented with abdominal pain. Labs showed leukocytosis, hyperglycemia, elevated anion gap, and positive serum ketones. Intravenous insulin with empirical antibiotics was started. Platelet decline was noticed from 154 000/uL to 39 000/uL on the following days, along with fever, hypotension, altered mentation, hyponatremia, and abdominal pain. A computed tomography scan of the abdomen showed BAH. Primary AI was confirmed with a cosyntropin stimulation test, and HIT was diagnosed with Heparin-PF4 IgG assay and serotonin release assay. His symptoms improved after hydrocortisone treatment. AI secondary to BAH from HIT is a rare complication, with most cases reported after orthopedic surgeries. Symptoms of AI are vague and similar to sepsis. If hyponatremia, and gastrointestinal symptoms are noticed, adrenal insufficiency should be suspected, and early stress dose steroid treatment should be considered. Steroid treatment in such cases has shown to improve survival. The symptoms of adrenal insufficiency are nonspecific and could be similar to sepsis. Electrolyte abnormalities and gastrointestinal symptoms could be hints for adrenal insufficiency, especially if risks for adrenal hemorrhage are present. Early stress dose treatment in such cases has shown a survival benefit.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC235 artigos no totalmostrando 127

2026

Beyond Neutropenic Fever: Severe Multiorgan Immune-Related Toxicity Induced by Pembrolizumab.

Cureus
2026

A case of the endoscopic removal of a gastric bezoar made of sodium zirconium cyclosilicate hydrate.

Internal medicine (Tokyo, Japan)
2025

Bilateral Adrenal Hemorrhage and Acute Adrenal Insufficiency Secondary to Heparin-Induced Thrombocytopenia After Coronary Artery Bypass Graft Surgery.

AACE endocrinology and diabetes
2025

Clinical characteristics of acute adrenal insufficiency in emergency patients: an analysis of data in Lhasa, Xizang Autonomous Region of China.

World journal of emergency medicine
2025

Acute adrenal insufficiency-induced hypotension following spinal surgery in a pediatric patient with Charcot-Marie-Tooth disease and severe scoliosis: a case report.

BMC pediatrics
2025

Case Report: Type II Bartter syndrome with a novel KCNJ1 variant in a premature neonate presenting with features of salt-wasting congenital adrenal crisis and pseudo-hypoaldosteronism.

Frontiers in pediatrics
2025

A Questionnaire Based Study on the Knowledge and Practice of Stress Steroid Dosing Protocol among Patients with Adrenal Insufficiency at a Tertiary Care Hospital in India.

Indian journal of endocrinology and metabolism
2025

Co-Occurrence of Hypophysitis and Thyroiditis Induced by PD-L1 Inhibitor Avelumab: Clinical Insights.

JCEM case reports
2025

The Delayed Cortisol Peak Effect After Severe Burn Injury: A Prospective Observational Study.

In vivo (Athens, Greece)
2025

Severe reversible cardiomyopathy associated with adrenal crisis caused by isolated adrenocorticotropin deficiency: a case report.

Frontiers in cardiovascular medicine
2025

Isolated adrenocorticotropic hormone deficiency manifested after COVID-19.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
2025

Comparison of two strategies of glucocorticoid withdrawal in patients with rheumatoid arthritis in low disease activity (STAR): a randomised, placebo- controlled, double-blind trial.

Annals of the rheumatic diseases
2025

Hypercalcemia Following Adrenalectomy for Cushing Syndrome in a Patient with Post-Surgical Hypoparathyroidism.

Diseases (Basel, Switzerland)
2025

Life With Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency: Challenges and Burdens.

The Journal of clinical endocrinology and metabolism
2025

Fatal Waterhouse-Friderichsen Syndrome caused by Streptococcus pneumoniae in a vaccinated adult with traumatic splenectomy: A case report.

Legal medicine (Tokyo, Japan)
2024

Temporal Trends in Acute Adrenal Insufficiency Events in Children With Congenital Adrenal Hyperplasia During 2019-2022.

Journal of the Endocrine Society
2024

Spontaneous Cushing's Disease Remission Induced by Pituitary Apoplexy.

Cureus
2024

A schedule for tapering glucocorticoid treatment in patients with severe SARS-CoV 2 infection can prevent acute adrenal insufficiency in the geriatric population.

Hormones (Athens, Greece)
2024

Clinical characteristics of systemic lupus erythematosus patients with adrenal hemorrhage.

Clinical rheumatology
2024

Diagnosis and management of secondary adrenal crisis.

Reviews in endocrine &amp; metabolic disorders
2023

Bilateral adrenal infarction and insufficiency associated with antiphospholipid syndrome and surgery: a case report.

International journal of emergency medicine
2024

Postpartum acute adrenal insufficiency of early-onset Sheehan syndrome: A case series study in a single center.

The journal of obstetrics and gynaecology research
2023

Acute adrenal insufficiency caused by antiphospholipid syndrome.

World journal of emergency medicine
2023

An unusual cause of abdominal pain: spontaneous bilateral adrenal hemorrhage.

Acta gastro-enterologica Belgica
2023

Acute adrenal insufficiency due to bilateral adrenal hemorrhage in the context of antiphospholipid syndrome.

Medicina clinica
2023

Pituitary apoplexy and cerebral infarction.

BMJ case reports
2022

[Analysis of fatal outcomes of meningococcal infection in adults].

Terapevticheskii arkhiv
2023

Acute adrenal insufficiency secondary to bilateral adrenal haemorrhage.

Endokrynologia Polska
2023

Acute Adrenal Insufficiency Caused by Mental Stress in a Patient With Adrenocorticotropic Hormone Deficiency.

Cureus
2023

A case of pituitary apoplexy mimicking viral meningitis.

Annals of medicine and surgery (2012)
2022

Life-Threatening Hypotension in a Brain-Injured, Multi-Trauma Patient With Unilateral Adrenal Gland Damage: How a Single Hydrocortisone Dose Revealed Relative Corticosteroid Insufficiency.

Cureus
2023

A case of shock after STEMI: Think beyond the cardiogenic one.

Clinical case reports
2022

Acute adrenal insufficiency in a patient with panhypopituitarism after vaccination against COVID-19 (BNT162b2 Pfizer-BioNTech).

Endocrinologia, diabetes y nutricion
2022

[Acute adrenal insufficiency: an entity that should not be missed].

Revue medicale suisse
2022

COVID-19 infection: from stress-related cortisol levels to adrenal glands infarction.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
2022

Case of Junctional Rhythm in the Setting of Acute Adrenal Insufficiency.

Cureus
2022

Pallister-Hall syndrome diagnosed in a young man after an acute adrenal crisis.

Clinical case reports
2022

Adrenal crisis prompted by SARS-CoV-2 infection in a patient with autoimmune polyglandular syndrome type 1 (APS type 1).

Endokrynologia Polska
2022

Apoplexy in sellar metastasis from papillary thyroid cancer: A case report and literature review.

Surgical neurology international
2022

A Case of Acute Adrenal Insufficiency: A Rare but Possible Cause of Hypercalcemia.

Cureus
2021

Parturient with Endocrine Disorders in the Intensive Care Unit.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
2022

Educational Case: Adrenocortical insufficiency-Causes and pathogenesis.

Academic pathology
2022

Management of Acute Adrenal Insufficiency-Related Adverse Events in Children with Congenital Adrenal Hyperplasia: Results of an International Survey of Specialist Centres.

Hormone research in paediatrics
2022

Waterhouse-Friderichsen Syndrome with Bilateral Adrenal Hemorrhage Associated with Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia in an Adult Patient with History of Intravenous Drug Use.

The American journal of case reports
2022

[Emergency card, emergency medication, and information leaflet for the prevention and treatment of adrenal crisis (Addison crisis): an Austrian consensus document].

Journal fur klinische Endokrinologie und Stoffwechsel
2022

Adrenal Crisis Secondary to Small Bowel Obstruction Caused by a Bezoar.

Cureus
2022

Pediatric Adrenal Insufficiency: Challenges and Solutions.

Therapeutics and clinical risk management
2022

[Acute adrenal insufficiency in a patient with panhypopituitarism after vaccination against COVID-19 (BNT162b2 Pfizer-Biontech)].

Endocrinologia, diabetes y nutricion
2019

Adrenocortical corticotropic insufficiency secondary to the use of cosmetic dermocorticoids.

Archive of clinical cases
2022

Factors influencing the levothyroxine dose in the hormone replacement therapy of primary hypothyroidism in adults.

Reviews in endocrine &amp; metabolic disorders
2022

Stress induced by messenger ribonucleic acid (RNA) vaccination may reveal acute adrenal insufficiency.

Endocrine
2022

Primary adrenal insufficiency due to bilateral adrenal infarction in COVID-19: a case report.

The Journal of clinical endocrinology and metabolism
2021

[Hypothalamic-pituitary dysfunction in a patient with neurosarcoidosis].

Ugeskrift for laeger
2021

Digestive symptoms in daily life of chronic adrenal insufficiency patients are similar to irritable bowel syndrome symptoms.

Scientific reports
2021

Death Due to Adrenal Crisis: Case Report and a Review of the Forensic Literature.

The American journal of forensic medicine and pathology
2021

Medical Management of Heparin-Induced Thrombocytopenia Causing Acute Adrenal Insufficiency.

Cureus
2021

A Case of Lung Adenocarcinoma with Long-Term Response after Late-Onset Pembrolizumab-Induced Acute Adrenal Insufficiency.

Case reports in oncology
2021

Bilateral adrenal hemorrhage after colectomy for perforated diverticulitis: A case report.

International journal of surgery case reports
2020

Acute Adrenal Insufficiency in a Patient with Metastatic Infiltrating Ductal Carcinoma.

Kansas journal of medicine
2020

Bilateral Adrenocortical Carcinoma Presenting as Acute Adrenal Insufficiency.

European endocrinology
2021

Reversibility of Acute Adrenal Insufficiency After Hip Replacement: A Case Series.

Endocrine, metabolic &amp; immune disorders drug targets
2020

Acute adrenal insufficiency due to paracoccidiodomycosis. Report of 2 cases.

Medical mycology case reports
2020

Adrenal insufficiency in coronavirus disease 2019: a case report.

Journal of medical case reports
2020

Bilateral Adrenal Hemorrhage in Coronavirus Disease 2019 Patient: A Case Report.

The Journal of clinical endocrinology and metabolism
2020

Multiple endocrinological failures as a clinical presentation of a metastatic lung adenocarcinoma.

Endocrinology, diabetes &amp; metabolism case reports
2020

A rare case of adrenal collision tumor: Myelolipoma and schwannoma in the adrenal gland.

SAGE open medical case reports
2020

A pictorial review of non-traumatic adrenergic crisis.

Emergency radiology
2020

Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis/Renal Failure, and Organomegaly (TAFRO) Syndrome with Bilateral Adrenal Hemorrhage in Two Caucasian Patients.

The American journal of case reports
2020

Acute adrenal insufficiency as a mysterious cause of shock following percutaneous coronary intervention: a cardiologist's nightmare.

BMJ case reports
2020

Guidelines for the management of glucocorticoids during the peri-operative period for patients with adrenal insufficiency: Guidelines from the Association of Anaesthetists, the Royal College of Physicians and the Society for Endocrinology UK.

Anaesthesia
2019

Pituitary Apoplexy Following Systemic Anticoagulation.

European journal of case reports in internal medicine
2020

[Fatal outcome of Netherton syndrome due to excessive use of topical corticosteroids in an adult patient].

Annales de dermatologie et de venereologie
2020

Cortisol and Aldosterone Responses to Hypoglycemia and Na Depletion in Women With Non-Classic 21-Hydroxylase Deficiency.

The Journal of clinical endocrinology and metabolism
2019

Multi-detector computed tomography in the diagnosis and characterization of adrenal gland traumatic injuries.

Gland surgery
2019

Frequent and prolonged administration of glucocorticoid for acute adrenal insufficiency treatment can cause diabetes mellitus: A case of holoprosencephaly.

Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology
2020

SEEN guidelines for the management and prevention of acute adrenal insufficiency.

Endocrinologia, diabetes y nutricion
2019

Acute Adrenal Insufficiency Precipitated by the Discontinuation of a Betamethasone and Dextrochlorpheniramine Combination: The Diagnostic Utility of an Echocardiographic Assessment of Systemic Vascular Resistance.

Internal medicine (Tokyo, Japan)
2019

Management of Endocrine Emergencies in the ICU.

Journal of pharmacy practice
2019

Bilateral adrenal myelolipomas presenting as acute adrenal insufficiency in an adult with congenital adrenal hyperplasia.

BMJ case reports
2019

A Case of Acute Exacerbation of Chronic Adrenal Insufficiency Due to Ipilimumab Treatment for Advanced Melanoma.

The American journal of case reports
2018

Therapy Side Effects in Systemic Lupus Erythematosus.

Current health sciences journal
2019

Catastrophic antiphospholipid syndrome causing ST-segment elevation myocardial infarction with non-obstructive coronary arteries.

BMJ case reports
2019

Acute Adrenal Insufficiency After an Antiemetic Dose of Dexamethasone: A Case Report.

A&amp;A practice
2019

Management of blunt adrenal gland injury in a community-based hospital.

Injury
2018

Acute Kidney Injury after Pembrolizumab-Induced Adrenalitis and Adrenal Insufficiency.

Case reports in nephrology and dialysis
2018

Acute adrenal insufficiency due to adrenal hemorrhage complicating colorectal surgery: Report of two cases and correlation with the antiphospholipid antibody syndrome.

International journal of surgery case reports
2018

[Diagnosis and Management of Adrenal Insufficiency].

Deutsche medizinische Wochenschrift (1946)
2019

A case of subacute combined degeneration of the spinal cord due to folic acid and copper deficiency.

Brain &amp; development
2018

Variations in the management of acute illness in children with congenital adrenal hyperplasia: An audit of three paediatric hospitals.

Clinical endocrinology
2018

[Rapid exacerbation of thrombotic microangiopathy accompanied by electrocardiogram abnormality leading to death].

[Rinsho ketsueki] The Japanese journal of clinical hematology
2019

Acute Adrenal Insufficiency in the Perioperative Period: A Case Report.

A&amp;A practice
2018

Acute Pericarditis as a Presentation of Adrenal Insufficiency.

Cureus
2018

Adrenal hemorrhage: A single center experience and literature review.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University
2018

Therapeutic patient education in adrenal insufficiency.

Annales d'endocrinologie
2018

[Diffuse hypertrichosis revealing non-classical congenital adrenal hyperplasia].

Annales de dermatologie et de venereologie
2018

A case of an infant suspected as IMAGE syndrome who were finally diagnosed with MIRAGE syndrome by targeted Mendelian exome sequencing.

BMC medical genetics
2018

SFE/SFEDP adrenal insufficiency French consensus: Introduction and handbook.

Annales d'endocrinologie
2018

Refractory collapse and severe burn: Think about acute adrenal insufficiency.

The American journal of emergency medicine
2017

Polyendocrinopathy Resulting From Pembrolizumab in a Patient With a Malignant Melanoma.

Journal of the Endocrine Society
2017

Group 6. Modalities and frequency of monitoring of patients with adrenal insufficiency. Patient education.

Annales d'endocrinologie
2017

Group 1. Epidemiology of primary and secondary adrenal insufficiency: Prevalence and incidence, acute adrenal insufficiency, long-term morbidity and mortality.

Annales d'endocrinologie
2017

Group 5: Acute adrenal insufficiency in adults and pediatric patients.

Annales d'endocrinologie
2017

Nontraumatic adrenal hemorrhage: the adrenal stress.

Radiology case reports
2017

Unusual Onset of Celiac Disease and Addison's Disease in a 12-Year-Old Boy.

International journal of environmental research and public health
2017

Lipoid congenital adrenal hyperplasia by steroidogenic acute regulatory protein (STAR) gene mutation in an Italian infant: an uncommon cause of adrenal insufficiency.

Italian journal of pediatrics
2016

Conduct protocol in emergency: Acute adrenal insufficiency.

Revista da Associacao Medica Brasileira (1992)
2016

SOCIETY FOR ENDOCRINOLOGY ENDOCRINE EMERGENCY GUIDANCE: Emergency management of acute adrenal insufficiency (adrenal crisis) in adult patients.

Endocrine connections
2016

Takotsubo-like syndrome triggered by fludrocortisone overdose for Addison's disease: a case report.

Journal of medical case reports
2016

Successful IVF pregnancy despite inadequate ovarian steroidogenesis due to congenital lipoid adrenal hyperplasia (CLAH): a case report.

Human reproduction (Oxford, England)
2016

Bilateral adrenal hemorrhage in polycythemia vera.

Journal of community hospital internal medicine perspectives
2016

[Endocrine and Metabolic Emergencies; Points of Initial Management. Topics: I. Acute adrenal insufficiency (Adrenal crisis)].

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine
2016

Darkened skin, vomiting, and salt cravings in a teenager · Dx?

The Journal of family practice
2016

Abdominal Distension and Vascular Collapse.

Journal of the Mississippi State Medical Association
2016

An acute adrenal insufficiency revealing pituitary metastases of lung cancer in an elderly patient.

The Pan African medical journal
2016

Acute adrenal insufficiency secondary to bilateral adrenal B-cell lymphoma: a case report and review of the literature.

Ecancermedicalscience
2016

Spontaneous idiopathic bilateral adrenal haemorrhage: a rare cause of abdominal pain.

BMJ case reports
2016

Acute Adrenal Insufficiency Associated with Rathke's Cleft Cyst.

Internal medicine (Tokyo, Japan)
2016

Acute adrenal insufficiency: an aide-memoire of the critical importance of its recognition and prevention.

Internal medicine journal
2016

A Case of Waterhouse-Friderichsen Syndrome Resulting from an Invasive Pneumococcal Infection in a Patient with a Hypoplastic Spleen.

Case reports in critical care
2017

Bilateral adrenal gland hemorrhage in a patient treated with rivaroxaban.

Blood coagulation &amp; fibrinolysis : an international journal in haemostasis and thrombosis
2015

Hyponatremia in a Teenager: A Rare Diagnosis.

Pediatric emergency care
2015

[Diagnostic pitfalls of acute adrenal insufficiency].

La Revue du praticien
2015

Diffusion MRI features of acute encephalopathy due to stopping steroid medication abruptly in congenital adrenal hyperplasia.

Annals of Indian Academy of Neurology
2014

Acute adrenal insufficiency as a first presentation of myelodysplastic syndrome and sigmoid colon adenocarcinoma: a case report.

Oxford medical case reports
2015

Spontaneous Bilateral Adrenal Haemorrhage after Duodenopancreatectomy: a case report.

La Clinica terapeutica
2015

Inadequate cortisol response to the tetracosactide (Synacthen®) test in non-classic congenital adrenal hyperplasia: an exception to the rule?

Hormone research in paediatrics
2015

Bilateral adrenal hemorrhage in a total knee patient associated with enoxaparin usage.

Arthroplasty today
Ver todos os 235 no EuropePMC

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Beyond Neutropenic Fever: Severe Multiorgan Immune-Related Toxicity Induced by Pembrolizumab.
    Cureus· 2026· PMID 41631071mais citado
  2. A case of the endoscopic removal of a gastric bezoar made of sodium zirconium cyclosilicate hydrate.
    Internal medicine (Tokyo, Japan)· 2026· PMID 41535045mais citado
  3. Acute adrenal insufficiency-induced hypotension following spinal surgery in a pediatric patient with Charcot-Marie-Tooth disease and severe scoliosis: a case report.
    BMC pediatrics· 2025· PMID 40646561mais citado
  4. Case Report: Type II Bartter syndrome with a novel KCNJ1 variant in a premature neonate presenting with features of salt-wasting congenital adrenal crisis and pseudo-hypoaldosteronism.
    Frontiers in pediatrics· 2025· PMID 40630717mais citado
  5. Bilateral Adrenal Hemorrhage and Acute Adrenal Insufficiency Secondary to Heparin-Induced Thrombocytopenia After Coronary Artery Bypass Graft Surgery.
    AACE endocrinology and diabetes· 2025· PMID 41467150mais citado
  6. [Management of emergencies in rheumatology].
    Med Klin Intensivmed Notfmed· 2026· PMID 41979866recente
  7. Clinical characteristics of acute adrenal insufficiency in emergency patients: an analysis of data in Lhasa, Xizang Autonomous Region of China.
    World J Emerg Med· 2025· PMID 40979801recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:95409(Orphanet)
  2. MONDO:0019801(MONDO)
  3. Insuficiencia Adrenal Primaria — Doenca de Addison(PCDT · Ministério da Saúde)
  4. GARD:19257(GARD (NIH))
  5. Busca completa no PubMed(PubMed)
  6. Artigo Wikipedia(Wikipedia)
  7. Q4057453(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Insuficiência suprarrenal aguda
Compêndio · Raras BR

Insuficiência suprarrenal aguda

ORPHA:95409 · MONDO:0019801
🇧🇷 Brasil SUS
Geral
Prevalência
Unknown
Herança
Autosomal recessive, Not applicable, X-linked dominant
CID-10
E27.2 · Crise addisoniana
CID-11
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0151467
EuropePMC
Wikidata
Wikipedia
Papers 10a
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