Linfo-histiocitose hemofagocítica secundária

Open-label Study of ELA026 in Participants With Secondary Hemophagocytic Lymphohistiocytosis (sHLH)

NCT05416307

RECRUTANDO

Hemophagocytic Lymphohistiocytosis (HLH) Evaluation and Research of Clinical, ImmUnoLogic and TranscriptomE Study

NCT06339177

RECRUTANDO

Zanubrutinib Combined With Rituximab in the Treatment of Secondary HLH in B-cell Lymphoma

NCT07270835

RECRUTANDO

Efficacy and Safety of Interferon-Gamma Monoclonal Antibody Combined With Dexamethasone in the Treatment of Refractory Adult Secondary Hemophagocytic Lymphohistiocytosis

NCT07531069

CONCLUÍDO

Evaluate Efficacy, Safety and Tolerability, PK and PD of Emapalumab in Children and Adults With MAS in Still's or SLE

NCT05001737

CONCLUÍDO

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NCT05416307 · Open-label Study of ELA026 in Participants With Secondary He…Recrutando

PHASE2, PHASE3

NCT06339177 · Hemophagocytic Lymphohistiocytosis (HLH) Evaluation and Rese…Recrutando

NCT07270835 · Zanubrutinib Combined With Rituximab in the Treatment of Sec…Recrutando

PHASE4

Outros ensaios clínicos

12 ensaios clínicos encontrados, 3 ativos.

Distribuição por fase

NCT07531069 · Efficacy and Safety of Interferon-Gamma Monoclonal Antibody …Concluído

NCT05001737 · Evaluate Efficacy, Safety and Tolerability, PK and PD of Ema…Concluído

PHASE3

NCT05841342 · Prospective Study of Immune Function and PD-1 Antibody Thera…UNKNOWN

NCT05384743 · Rituximab Monotherapy for EBV-HLH and CAEBVUNKNOWN

PHASE3

NCT03311854 · A Study to Investigate the Safety and Efficacy of Emapalumab…Concluído

PHASE2

NCT03795909 · Ruxolitinib Combined With Dexamethasone for HLHUNKNOWN

PHASE1, PHASE2

NCT01547143 · Pilot Study of Etoposide-based Therapy and Hematopoietic Cel…Encerrado

NA

Ver todos no ClinicalTrials.gov

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Publicações mais relevantes

Timeline de publicações

525 papers (10 anos)

#1

Neurological Involvement in Adult-Onset Secondary Hemophagocytic Lymphohistiocytosis: Clinical Features and Prognostic Implications.

Brain and behavior2026 Feb

Secondary hemophagocytic lymphohistiocytosis (sHLH) with central nervous system (CNS) involvement poses significant diagnostic and therapeutic challenges. This study aimed to characterize the clinical features, laboratory profiles, and prognostic impact of neurological involvement in adult-onset sHLH. We analyzed 130 adult sHLH patients, comparing 28 with CNS involvement to 102 without neurological manifestations. Clinical parameters, neuroimaging, cerebrospinal fluid (CSF) profiles, cytokine levels, treatment responses, and survival outcomes were evaluated. Patients with CNS involvement were older (median age, 54 vs. 46 years; p = 0.013) and had higher disease severity (median HScore, 250 vs. 210; p < 0.001). Malignancy-associated sHLH was more prevalent in the CNS-positive group (42.9% vs. 29.4%; p = 0.038). Neurological manifestations included altered mental status, impaired consciousness, and seizures. Neuroimaging revealed abnormalities in 71.4% of the cases, primarily T2-weighted fluid-attenuated inversion recovery hyperintensities and leptomeningeal enhancement. CNS-positive patients exhibited markedly elevated inflammatory markers, most notably CSF Interleukin-6 (p < 0.001). In multivariable analysis adjusted for malignancy, age, ferritin, and HScore, CNS involvement independently predicted mortality (adjusted HR = 2.0, 95% CI: 1.1-3.7, p = 0.023), with a significantly shorter median overall survival (6.5 vs. 11.5 months, p < 0.0001). Malignancy-associated etiology and HScore ≥ 250 were also independent prognostic factors. The DEP (dexamethasone, etoposide, and polyethylene glycol-asparaginase) regimen achieved a faster median time to initial response than the HLH-94 protocol (9 vs. 14 days, p = 0.02). CNS involvement defines a severe phenotype of adult-onset sHLH, characterized by malignancy-prone etiology, intense neuroinflammation, and poor prognosis. We establish CNS involvement as an independent predictor of mortality, underscoring the critical need for early recognition and CNS-directed therapies.

#2

Fatal EBV-Associated Posttransplant Lymphoproliferative Disease and Secondary Hemophagocytic Lymphohistiocytosis in a Pediatric Patient With Hurler Syndrome Following Hematopoietic Cell Transplantation: A Case Report and Review of the Literature.

Pediatric blood & cancer2026 Jan

#3

A 70-Year-Old Woman Receiving Immunosuppressive Therapy Presenting With Iliopsoas Abscess, Pulmonary Miliary Tuberculosis, and Secondary Hemophagocytic Lymphohistiocytosis.

The American journal of case reports2026 Feb 25

BACKGROUND Miliary tuberculosis (TB) carries an increased risk in immunosuppressed patients. Extrapulmonary manifestations include hemophagocytic lymphohistiocytosis (HLH) and iliopsoas abscess. The coexistence of multiple extrapulmonary involvements can result in a significant diagnostic challenge. In the treatment of TB-associated HLH, the use of immunosuppressive agents remains controversial because of the risk of exacerbating TB. This report describes the case of a 70-year-old woman with rheumatoid arthritis presenting with an iliopsoas abscess, pulmonary miliary tuberculosis, and secondary HLH. CASE REPORT A 70-year-old Japanese woman with a history of rheumatoid arthritis treated with immunosuppressive therapy including golimumab and iguratimod presented with fever, dyspnea, cough, and weight loss. Imaging demonstrated an iliacus muscle abscess and possible pulmonary miliary tuberculosis. Clinical manifestations, laboratory findings, and bone marrow biopsy results were consistent with a diagnosis of HLH. Acid-fast bacilli cultures were positive for Mycobacterium tuberculosis from the abscess, bronchoalveolar lavage fluid, urine, and blood, confirming the diagnosis of miliary TB. The patient received the HLH-94 treatment protocol and antituberculosis therapy for TB-associated HLH, but unfortunately died of multi-organ failure. CONCLUSIONS In immunosuppressed patients presenting with multi-organ involvement, such as iliopsoas abscess and HLH, clinicians should maintain a high index of suspicion for miliary TB and pursue proactive diagnostic evaluation. Given the limited evidence supporting immunomodulatory therapies in TB-associated HLH, management should be individualized and guided by multidisciplinary discussion.

#4

Case Reports of Visceral Leishmaniasis-Associated Hemophagocytic Lymphohistiocytosis in Adults: A Complex Immune Phenomenon.

Reports (MDPI)2026 Jan 20

Background: Visceral Leishmaniasis (VL), a severe systemic parasitic disease caused by Leishmania species, can be complicated by secondary Hemophagocytic Lymphohistiocytosis (HLH). HLH is a life-threatening hyperinflammatory syndrome characterized by excessive immune activation that results in multiorgan dysfunction. The co-occurrence of VL and HLH in adults is a rare but critical diagnostic and therapeutic challenge, often leading to fatal outcomes if treatment is delayed. Case Presentation: We present two cases of adult males (60 and 72 years old) from Greece, an endemic area for L. infantum, who presented with prolonged fever, pancytopenia, hepatosplenomegaly, and impaired liver function. Both patients exhibited extremely elevated ferritin (all > 2000 ng/mL and one > 20,000 ng/mL) and hypertriglyceridemia, fulfilling key laboratory criteria for HLH. Diagnosis was confirmed by the visualization of Leishmania amastigotes in bone marrow aspirates, which also demonstrated features of hemophagocytosis. Case 1, critically ill with acute kidney injury and coagulopathy, required combined treatment with liposomal Amphotericin B and immunoglobulin therapy for HLH. Case 2, who showed rapid and "spectacular improvement" solely after receiving liposomal Amphotericin B, did not require HLH-specific immunosuppression. Conclusions: VL-associated HLH should be considered in adult patients presenting with complex systemic inflammation, fever, and cytopenias, particularly in endemic settings. Our cases illustrate that the prompt initiation of anti-leishmanial therapy with liposomal Amphotericin B can be sufficient to reverse the HLH syndrome by eliminating the infectious trigger. However, intensive immunomodulation may be necessary in patients presenting with critical multi-organ failure.

#5

Avoidance of related donors in CAEBV with germline immune variants: long-termoutcome of matched unrelated donor HSCT - a case report.

Annals of hematology2026 Feb 19

This study reports an adult-onset case of NK cell-predominant chronic active Epstein-Barr virus infection (CAEBV) harboring multiple heterozygous germline variants affecting antiviral immunity. Functional assessments of NK cell cytotoxicity and degranulation in the patient and her family members revealed subclinical immune defects in several relatives, leading to the exclusion of related donors. The patient ultimately underwent a fully HLA-matched unrelated donor hematopoietic stem cell transplantation (MUD-HSCT), achieving early virologic remission and complete donor chimerism. However, the post-transplant course was complicated by severe immune-related adverse events, including acute and chronic graft-versus-host disease (GVHD), thrombotic microangiopathy, viral reactivations, and secondary hemophagocytic lymphohistiocytosis, ultimately resulting in death due to severe pulmonary infection and multi-organ failure. This case underscores the critical role of immunogenetic risk stratification in guiding transplant decisions. Matched unrelated donor transplantation, supported by comprehensive functional and genetic screening, offers curative potential while avoiding the use of immunologically compromised donors. Nevertheless, long-term outcomes in CAEBV depend not only on virologic remission but also on sustained immune reconstitution. In addition, this report reviews precision transplantation strategies that integrate host genetic background, immune function, and viral dynamics, providing a roadmap for the future management of CAEBV.

Publicações recentes

Secondary Hemophagocytic Lymphohistiocytosis in a Rocky Mountain Spotted Fever Patient.

Cureus2026 Mar

Pneumococcal HUS in infancy masking DGKE-related thrombotic microangiopathy with secondary hemophagocytic lymphohistiocytosis.

Pediatr Nephrol2026 Apr 14

Clinical Profile and Outcome of Children with Scrub typhus: A Tertiary Care Centre Observation.

J Trop Pediatr2026 Apr 11

Secondary Haemophagocytic Lymphohistiocytosis Triggered by Adult-Onset Still's Disease in Mid-trimester Pregnancy Initially Presenting as an Upper Respiratory Tract Infection: A Case Report.

Cureus2026 Mar

Secondary Hemophagocytic Lymphohistiocytosis as the Initial Presentation of Metastatic Carcinoma of Likely Colorectal Origin.

J Brown Hosp Med2026

Ver todas no PubMed

📚 EuropePMC348 artigos no totalmostrando 199

Critical care (London, England)

Chronic granulomatous disease with suspected secondary hemophagocytic lymphohistiocytosis: a case report and hypothesis-generating rationale for neuroimmune modulation.

The American journal of case reports

A 70-Year-Old Woman Receiving Immunosuppressive Therapy Presenting With Iliopsoas Abscess, Pulmonary Miliary Tuberculosis, and Secondary Hemophagocytic Lymphohistiocytosis.

Case Reports of Visceral Leishmaniasis-Associated Hemophagocytic Lymphohistiocytosis in Adults: A Complex Immune Phenomenon.

Reports (MDPI)

Avoidance of related donors in CAEBV with germline immune variants: long-termoutcome of matched unrelated donor HSCT - a case report.

SAGE open medical case reports

Secondary hemophagocytic lymphohistiocytosis following blood transfusion in the absence of an identifiable trigger.

Interferon-gamma blocking as a promising treatment for severe liver dysfunction in secondary hemophagocytic lymphohistiocytosis after liver transplantation.

JPGN reports

Journal of infection and public health

Hemophagocytic lymphohistiocytosis secondary to isolated bronchial infection caused by Mycobacterium marseillense in a patient with GATA2 missense mutation: A rare case report.

Cytomegalovirus Infection-Associated Hemophagocytic Lymphohistiocytosis and Histiocytic Necrotising Lymphadenitis Progressing to Systemic Lupus Erythematosus: A Case Report.

Navigating a Dual Hyperinflammatory State: Overlap of Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) and Secondary Hemophagocytic Lymphohistiocytosis (HLH) in a Child.

An Unusual Presentation of Secondary Hemophagocytic Lymphohistiocytosis With Melena: A Case Report.

Secondary hemophagocytic lymphohistiocytosis concurrent with febrile infection-related epilepsy syndrome in a child.

Seizure

Combination therapy success in refractory pediatric visceral leishmaniasis with hemophagocytic lymphohistiocytosis: A case report.

Neurological Involvement in Adult-Onset Secondary Hemophagocytic Lymphohistiocytosis: Clinical Features and Prognostic Implications.

Brain and behavior

Polish archives of internal medicine

Secondary hemophagocytic lymphohistiocytosis in patients treated with peritoneal dialysis.

Influenza B-Triggered Secondary Hemophagocytic Lymphohistiocytosis in an Adult Male: A Diagnostic Challenge.

Journal of medical case reports

Secondary hemophagocytic lymphohistiocytosis in a patient with severe leptospirosis: a case report.

A case report of hemophagocytic lymphohistiocytosis occurring during ibrutinib chemotherapy with a literature review.

Coagulation dysfunction in children with secondary hemophagocytic lymphohistiocytosis: a comprehensive analysis.

Annals of medicine

Presentation, Diagnosis, and Acute Treatment of Secondary Hemophagocytic Lymphohistiocytosis: A Case Report.

[Clinical Characteristics and Prognosis of Children with Hematological Malignancies Complicated by Secondary Hemophagocytic Lymphohistiocytosis].

Emerging infectious diseases

Retrospective Multicenter Study of Human Granulocytic Anaplasmosis, France, 2012-2024.

Corrigendum to Analysis of risk factors for the early death of lymphocyte subsets in adult patients with secondary hemophagocytic lymphohistiocytosis Experimental Hematology Volume 153 (2025), 105286.

Experimental hematology

Pembrolizumab-Associated Hemophagocytic Lymphohistiocytosis in Clear Cell Renal Carcinoma: Case Report and Literature Review.

Reports (MDPI)

Intravascular Large B-cell Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis and Pyrexia of Unknown Origin: A Diagnostic Dilemma.

Adult-Onset Still's Disease Complicated by Secondary Hemophagocytic Lymphohistiocytosis: A Case Report.

Efficacy of Etoposide-Based Therapy in Pediatric Secondary Hemophagocytic Lymphohistiocytosis.

Improving Recognition of Secondary Hemophagocytic Lymphohistiocytosis (HLH) through a Ferritin-Based Automated Alert: An Interrupted Time Series Analysis.

Clinical chemistry

Secondary Hemophagocytic Lymphohistiocytosis in a Patient With Crohn's Disease Receiving Infliximab: A Diagnostic Challenge.

Therapeutic Plasma Exchange in Pediatric Care: Insights from a Tertiary Care Centre Experience.

Indian pediatrics

Medical science monitor : international medical journal of experimental and clinical research

Perforin Expression and Natural Killer-Cell Proportion as Biomarkers in Secondary Hemophagocytic Lymphohistiocytosis.

Invasive fusariosis after CD19 chimeric antigen receptor T-cell therapy.

ASM case reports

Histoplasmosis-Associated Hemophagocytic Lymphohistiocytosis in the Setting of Granulomatosis With Polyangiitis.

Journal of medical cases

Fatal EBV-Associated Posttransplant Lymphoproliferative Disease and Secondary Hemophagocytic Lymphohistiocytosis in a Pediatric Patient With Hurler Syndrome Following Hematopoietic Cell Transplantation: A Case Report and Review of the Literature.

Pediatric blood & cancer

Monocyte/macrophages may exert prominent roles in macrophage activation syndrome.

Characteristics of Secondary Malignancy Among Children With Primary Immunodeficiency Disorders in Saudi Arabia.

Analysis of risk factors for early death of lymphocyte subsets in adult patients with secondary hemophagocytic lymphohistiocytosis.

Experimental hematology

Clinical manifestations and outcomes of EBV-related secondary hemophagocytic lymphohistiocytosis.

Case Report: Longitudinal mass cytometry profiling of a patient with disseminated histoplasmosis and secondary hemophagocytic lymphohistiocytosis.

International journal of laboratory hematology

Pediatric Severe Eosinophilia: Etiological Spectrum, Diagnostic Algorithm, and Case-Based Insights From a Tertiary Care Center.

European journal of case reports in internal medicine

Cytomegalovirus Viremia as A Cause of Fever of Unknown Origin in an Immunocompetent Adult.

Journal of Brown hospital medicine

Secondary Hemophagocytic Lymphohistiocytosis Triggered by Subdural Empyema due to Streptococcus constellatus: A Rare Triad.

Massive suprachoroidal hemorrhage in dengue-associated HLH: A clinical image.

IDCases

Case Report: Life-threatening overlap of hemophagocytic syndrome and atypical hemolytic uremic syndrome in a patient with autoimmune polyglandular syndrome type 1 successfully treated with targeted immunotherapy.

Clinical advances in hematology & oncology : H&O

Diagnosis and treatment of secondary hemophagocytic lymphohistiocytosis in adults.

Laboratory diagnosis of 44 cases of pediatric histiocytic necrotizing lymphadenitis.

Prelude to the perfect storm: the many triggers of secondary hemophagocytic lymphohistiocytosis.

Postgraduate medicine

Imaging in Hemophagocytic Lymphohistiocytosis: A Comprehensive Pictorial Essay.

Journal of clinical medicine

Sweet Syndrome-like Dermatosis as a Precursor to Overlapping Hematologic Malignancies: A Case Report and Review.

Pediatric transplantation

Exploring the Complexities of Liver Transplantation for Secondary Hemophagocytic Lymphohistiocytosis-Associated Acute Liver Failure.

Hodgkin Lymphoma: An Unusual Presentation With Hemophagocytic Lymphohistiocytosis.

Prognostic value of blood inflammatory composite markers in the survival of pediatric patients with secondary hemophagocytic lymphohistiocytosis.

Case reports in infectious diseases

Secondary Dengue Infection Complicated by Hemophagocytic Lymphohistiocytosis: A Case Report.

A Comprehensive Guide to Typhoidal Anemia.

Prague medical report

Italian journal of pediatrics

Development of an early mortality risk prediction model for pediatric patients with secondary hemophagocytic lymphohistiocytosis.

Archives of gynecology and obstetrics

Secondary hemophagocytic lymphohistiocytosis associated with adjuvant pembrolizumab therapy in a young patient with triple-negative breast cancer: a case report with literature review.

Medicina (Kaunas, Lithuania)

Characteristics of 21 Patients with Secondary Hemophagocytic Lymphohistiocytosis-Insights from a Single-Center Retrospective Study.

Annals of medicine and surgery (2012)

Body mass index and hemophagocytic lymphohistiocytosis: a risk assessment in HIV-positive leukemia patients.

Clinical features, course, and risk factors of infection-associated secondary hemophagocytic lymphohistiocytosis.

Infection

Ruxolitinib targets JAK-STAT signaling to modulate neutrophil activation in refractory macrophage activation syndrome.

Blood

Secondary hemophagocytic lymphohistiocytosis in a 5-month-old infant with IBD post-COVID-19: a case report.

Orphanet journal of rare diseases

Perspectives on the current diagnostic and treatment paradigms in secondary hemophagocytic lymphohistiocytosis (HLH).

Signal transduction and targeted therapy

Deep insight into cytokine storm: from pathogenesis to treatment.

Hematology/oncology clinics of North America

Recognizing and Managing Secondary Hemophagocytic Lymphohistiocytosis in Adults: A Practical Clinical Guide.

Macrophage Activation Syndrome as an Atypical Manifestation of Mixed Connective Tissue Disease in a 14-Year-Old Girl: A Case Report.

Methylmalonic acidemia with recurrent hemophagocytic lymphohistiocytosis: a case report and review of the literature.

BMC pediatrics

Deutsche medizinische Wochenschrift (1946)

[Secondary hemophagocytic lymphohistiocytosis due to icteric leptospirosis with acute renal failure].

Hematology/oncology clinics of North America

Immune Effector Cell-associated Hemophagocytic Lymphohistiocytosis-like Syndrome (IEC-HS).

Clinicopathological Prognostic Model for Survival in Adult Patients With Secondary Hemophagocytic Lymphohistiocytosis.

Journal of Brown hospital medicine

Disseminated Histoplasmosis with Secondary Hemophagocytic Lymphohistiocytosis in a Renal Transplant Recipient on Belatacept-based Immunosuppression.

Einstein (Sao Paulo, Brazil)

Severe dengue, aneurysmal sub-arachnoid hemorrhage, and hemophagocytic lymphohistiocytosis: a rare case combination.

Babesiosis with low parasitemia as a cause of secondary hemophagocytic lymphohistiocytosis in a previously healthy adult.

IDCases

Secondary Hemophagocytic Lymphohistiocytosis in severe COVID-19 - a retrospective cohort study.

Scientific reports

Phytomedicine : international journal of phytotherapy and phytopharmacology

Tetrandrine alleviates macrophage activation syndrome after CAR-T cell therapy.

Aggressive T-cell Lymphoma Smoldering As Hemophagocytic Lymphohistiocytosis: A Diagnostic and Medical Challenge.

Critical care explorations

Proteomic Analyses in COVID-19-Associated Secondary Hemophagocytic Lymphohistiocytosis.

Journal of internal medicine

Intercontinentally validated diagnostic criteria for secondary hemophagocytic lymphohistiocytosis-So welcome!

Journal of internal medicine

Multicenter validation of secondary hemophagocytic lymphohistiocytosis diagnostic criteria.

Preoperative pembrolizumab‑induced hemophagocytic lymphohistiocytosis in a patient with breast cancer: A case report.

Oncology letters

British journal of hospital medicine (London, England : 2005)

COX Regression Analysis and Mortality Risk Prediction Model of 85 Adult Patients with Secondary Hemophagocytic Lymphohistiocytosis.

PRMT5 inhibition reduces hyperinflammation in a murine model of secondary hemophagocytic lymphohistiocytosis.

Blood advances

Macrophage Activation Syndrome/Secondary Hemophagocytic Lymphohistiocytosis in Adult-Onset Still's Disease: An Uncommon Initial Presentation in a Young Nepalese Female: A Case Report.

Journal of immunotherapy (Hagerstown, Md. : 1997)

Secondary Hemophagocytic Lymphohistiocytosis Syndrome Developing in a Patient With Chronic Lymphocytic Leukemia Under a Long-term Ibrutinib Therapy: A Case Report and Literature Review.

Hemophagocytic Lymphohistiocytosis Secondary to Miliary Tuberculosis in a Resource-Limited Setting: A Case Report.

Case report: A cyclic neutropenia patient with ELANE mutation accompanied by hemophagocytic lymphohistiocytosis.

Oxford medical case reports

A rare case of complicated typhoid fever presenting with secondary Hemophagocytic Lymphohistiocytosis.

Two-Month Duration of Esophageal Button Battery Impaction in a 23-Month-Old Boy: A Case Report.

Indian journal of medical microbiology

A vector borne, airborne and food borne infection with secondary hemophagocytic lymphohistocytosis: Case of triple infections in an immuno-competent patient.

Hemophagocytic Lymphohistiocytosis (HLH): A Rare Complication of Dengue Hemorrhagic Fever.

Treatment of Secondary Hemophagocytic Lymphohistiocytosis Associated With Diffuse Large B-cell Lymphoma Using Loncastuximab Tesirine As Lymphoma-Directed Therapy.

A Rare Case of Disseminated Strongyloidiasis Leading to Multisystem Organ Failure Following Deceased Donor Kidney Transplantation.

The American surgeon

The American journal of tropical medicine and hygiene

Enteric Fever with Intussusception, Myocardial Dysfunction, Encephalopathy, and Hemophagocytic Lymphohistiocytosis in an Indian Child.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

A novel mutation in a craniofacial pustular pyoderma gangrenosum patient with secondary hemophagocytic lymphohistiocytosis.

CircMETTL3-156aa reshapes the glycolytic metabolism of macrophages to promote M1 polarization and induce cytokine storms in sHLH.

Cell death discovery

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

The HScore to Diagnose HLH in Scrub Typhus: Overdiagnosis or under Diagnosis and Does It Really Matter?

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

Predicting Secondary Hemophagocytic Lymphohistiocytosis in Adult Patients with Scrub Typhus and Its Prognostic Significance.

American journal of hematology

Peripheral blood smear reveals human granulocytic anaplasmosis, a rare cause of hemophagocytic lymphohistiocytosis.

World journal of oncology

Secondary Hemophagocytic Lymphohistiocytosis Following Dostarlimab Treatment in a Patient With Metastatic Endometrial Cancer.

Immune biomarkers and secondary hemophagocytic lymphohistiocytosis: a scoping review protocol.

JBI evidence synthesis

Indian journal of pathology & microbiology

EBV-triggered secondary macrophage activation syndrome in the backdrop of lupus in an adult.

[Effect of Plasma Epstein-Barr Virus Nucleic Acid Loads on the Clinical Features and Prognosis in Adult Secondary Hemophagocytic Lymphohistiocytosis].

bioRxiv : the preprint server for biology

Identification of biomarkers for COVID-19 associated secondary hemophagocytic lymphohistiocytosis.

Hemophagocytic Lymphohistiocytosis Unmasking Systemic Lupus Erythematosus: Management With Belimumab and a Case Study.

Secondary hemophagocytic lymphohistiocytosis triggered by Staphylococcus aureus bacteremia: A case report and systemic review.

IDCases

Other Immunomodulatory Treatment for Cytokine Storm Syndromes.

IL-1 Family Blockade in Cytokine Storm Syndromes.

Etoposide Therapy of Cytokine Storm Syndromes.

Cytokine Storm and Sepsis-Induced Multiple Organ Dysfunction Syndrome.

Genetics of Acquired Cytokine Storm Syndromes : Secondary HLH Genetics.

PLoS neglected tropical diseases

Human monocytotropic ehrlichiosis-A systematic review and analysis of the literature.

Disseminated tuberculosis complicated by intramuscular abscesses, meningoencephalitis, and hemophagocytic lymphohistiocytosis: a case report.

BMC infectious diseases

Unleashing the Cytokine Storm: A Case of Macrophage Activation Syndrome in Systemic Lupus Erythematosus.

Macrophage Activation Syndrome in Viral Sepsis.

Viruses

CRP and sCD25 help distinguish between adult-onset Still's disease and HLH.

Unmasking the Culprits: A Case of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis Presenting With Mouth Ulcers and Nosebleeds.

Journal of leukocyte biology

Comprehensive mapping of immune perturbations associated with secondary hemophagocytic lymphohistiocytosis.

Sudanese journal of paediatrics

From multisystem inflammatory syndrome in children to secondary hemophagocytic lymphohistiocytosis a series of misfortunate events: case report and review of literature.

Diarrhea as the Initial Presentation in a Patient With HIV Diagnosed With Hodgkin's Lymphoma.

Clinical hematology international

A Retrospective Review of Secondary Hemophagocytic Lymphohistiocytosis (HLH) and Dengue-associated HLH from a Teaching Hospital in Singapore.

Pediatric rheumatology online journal

Single center clinical analysis of macrophage activation syndrome complicating juvenile rheumatic diseases.

Management of hematological patients requiring emergency chemotherapy in the intensive care unit.

Intensive care medicine

Malignancy-Associated Secondary Hemophagocytic Lymphohistiocytosis Mimicking an Infection: A Case Report and Review of the Literature.

A Case of Secondary Hemophagocytic Lymphohistiocytosis in a Patient With T-cell Lymphoma.

Comprehensive evaluation of immune dysregulation in secondary hemophagocytic lymphohistiocytosis.

Virulence

Journal of investigative medicine high impact case reports

Marginal Zone Lymphoma Manifesting as Macrophage Activation Syndrome: A Case Report.

World journal of clinical cases

Low interleukin-10 level indicates a good prognosis in Salmonella enterica serovar typhimurium-induced pediatric hemophagocytic lymphohistiocytosis: A case report.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

A 14-step desensitization protocol for sebelipase alfa hypersensitivity in a patient with Wolman disease and secondary hemophagocytic lymphohistiocytosis.

Open forum infectious diseases

Tuberculosis-Associated Hemophagocytic Lymphohistiocytosis: Diagnostic Challenges and Determinants of Outcome.

Probable secondary hemophagocytic lymphohistiocytosis manifesting as central nervous system lesions after COVID-19 vaccination: a case report.

Frontiers in neurology

Critical care explorations

Ruxolitinib, IV Immunoglobulin, and High-Dose Glucocorticoids for Critically Ill Adults With Secondary Hemophagocytic Lymphohistiocytosis: A Single-Center Observational Pilot Study.

Arthritis & rheumatology (Hoboken, N.J.)

The Systemic Score May Identify Life-Threatening Evolution in Still Disease: Data from the GIRRCS AOSD-Study Group and the AIDA Network Still Disease Registry.

Hemophagocytic Lymphohistiocytosis Associated With Human Herpesvirus-6 (HHV-6) Infection in an Immunocompetent Adult: A Case Report.

Secondary hemophagocytic lymphohistiocytosis in pediatric patients with visceral leishmaniasis and Epstein-Barr virus infection.

Dengue Hemorrhagic Fever Causing Postpartum Hemorrhage and Hemophagocytic Lymphohistiocytosis in a Young Woman: A Case Report.

Innere Medizin (Heidelberg, Germany)

[Combined immunosuppression with cyclosporin A, mycophenolate mofetil (MMF) and dexamethasone for activity control of recurrent secondary hemophagocytic lymphohistiocytosis (sHLH) with underlying systemic lupus erythematosus (SLE)].

Severe Lymphoma-Associated Hemophagocytic Syndrome in a Young Woman.

Experimental & molecular medicine

Immunopathology of and potential therapeutics for secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome: a translational perspective.

Association of a decreased platelet count with poor survival in patients with adult secondary hemophagocytic lymphohistiocytosis.

Value of hemophagocytosis in the diagnosis of hemophagocytic lymphohistiocytosis in critically ill patients.

Annals of African medicine

Hemophagocytic lymphohistiocytosis: A scourge for the physician and bane to the bone marrow.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Comparison of different treatment regimens and analysis of prognostic factors in secondary hemophagocytic lymphohistiocytosis in adults: A single-center retrospective study.

Case Report: Successful avoidance of etoposide for primary hemophagocytic lymphohistiocytosis-induced multiple organ dysfunction syndrome using emapalumab.

The American journal of tropical medicine and hygiene

Case Report: A Case of Complicated Typhoid Fever with Rhabdomyolysis and Hemophagocytic Lymphohistiocytosis.

Current research in translational medicine

Performances of the H-score and the HLH-2004 score in the positive diagnosis of secondary hemophagocytic lymphohistiocytosis.

Healthcare (Basel, Switzerland)

A 10-Year Retrospective Study on Pediatric Visceral Leishmaniasis in a European Endemic Area: Diagnostic and Short-Course Therapeutic Strategies.

Q fever, a rare cause of secondary hemophagocytic lymphohistiocytosis.

GMS infectious diseases

Elevated monocyte HLA-DR in pediatric secondary hemophagocytic lymphohistiocytosis: a retrospective study.

[Analysis of High-Risk Clinical Factors of Early Death in Secondary Hemophagocytic Lymphohistiocytosis].

The American Journal of dermatopathology

Foamy Macrophages in a Case of Mononucleosis With Amoxicillin-Induced Rash, Hyperlipidemia, and Hemophagocytic Lymphohistiocytosis.

Hemophagocytic Lymphohistiocytosis: A Rare Complication of COVID-19 in a Patient With Sickle Cell Anemia.

GE Portuguese journal of gastroenterology

Severe Acute Liver Injury due to Secondary Hemophagocytic Lymphohistiocytosis: A Case Report.

Journal of liver transplantation

Solid organ graft-versus-host disease in a recipient of a COVID-19 positive liver graft.

Epithelioid granulomas with proliferating T-lymphocytes in bone marrow in a patient with infectious mononucleosis modified by secondary hemophagocytic lymphohistiocytosis.

Pathology international

The signature and predictive value of immune parameters in patients with secondary hemophagocytic lymphohistiocytosis.

Immunobiology

An elevated HScore is associated with poor clinical outcomes in COVID-19.

Revista medica de Chile

Outcome of patients with primary and secondary hemophagocytic lymphohistiocytosis: A retrospective analysis from a tertiary care center.

Secondary Hemophagocytic Lymphohistiocytosis: A Series of Three Cases.

Hemophagocytic lymphohistiocytosis-how common and how severe is it as a complication of malaria? Retrospective case series and review of the literature.

Infection

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Severe acute herpes virus type 2 primo-infection and its association with anti-type 1 interferon autoantibodies.

Genetic and clinical characteristics of primary hemophagocytic lymphohistiocytosis in children.

Rare case of secondary hemophagocytic lymphohistiocytosis in a patient with disseminated histoplasmosis.

Pediatric investigation

CLINICAL UTILITY OF INTERLEUKIN-1 INHIBITORS IN PEDIATRIC SEPSIS.

Shock (Augusta, Ga.)

Case reports in critical care

Sepsis as the Grand Mimic of Secondary Hemophagocytic Lymphohistiocytosis: Serratia marcescens Bacteremia with Concomitant Decompensated Cirrhotic Liver Disease.

Ehrlichia-Induced Hemophagocytic Lymphohistiocytosis (HLH) With No Response to Doxycycline Treatment.

Experimental and therapeutic medicine

Secondary hemophagocytic lymphohistiocytosis in children (Review).

Secondary Hemophagocytic Lymphohistiocytosis Due to Typhoid Fever.

Zhonghua wei zhong bing ji jiu yi xue

[Clinical features and risk factors for secondary hemophagocytic lymphohistiocytosis in elderly patients with severe SARS-CoV-2 infection: a multicenter retrospective cohort study].

International medical case reports journal

Acute Liver Failure Caused by Secondary Hemophagocytic Lymphohistiocytosis After COVID-19 Vaccination - Case Report and Literature Review.

A novel prognosis-prediction model based on coagulation indicators in secondary hemophagocytic lymphohistiocytosis.

Clinical medicine (London, England)

Secondary hemophagocytic lymphohistiocytosis: an unusual complication in disseminated Mycobacterium tuberculosis.

CXCL9 inhibition does not ameliorate disease in murine models of both primary and secondary hemophagocytic lymphohistiocytosis.

Scientific reports

Hemophagocytic inflammatory syndrome in ADA-SCID: report of two cases and literature review.

Anakinra versus etoposide-based therapy added to high-dose steroids for the treatment of secondary hemophagocytic lymphohistiocytosis.

[Expression and Clinical Significance of Serum sFas/sFasL in Patients with Secondary Hemophagocytic Lymphohistiocytosis].

A Diagnostic Dilemma: Adult-Onset Still's Disease With Secondary Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome?

Journal of medical cases

Journal of the Chinese Medical Association : JCMA

Clinical value of soluble fms-like tyrosine kinase 1 (sFlt-1) in adult secondary hemophagocytic lymphohistiocytosis.

Case report: Sulfasalazine-induced hypersensitivity.

Frontiers in medicine

Risk factors and prognosis of early death in secondary hemophagocytic lymphohistiocytosis.

Prognostic value of the albumin-bilirubin score in patients with non-Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis.

Secondary hemophagocytic lymphohistiocytosis associated with heat stroke: A case report and review of literature.

A predictive model for identifying secondary underlying diseases of hemophagocytic lymphohistiocytosis.

Primary Gastrointestinal Diffuse Large B-cell Lymphoma Presenting as Ileal Perforation.

Presentations and outcomes of familial hemophagocytic lymphohistiocytosis in the pediatric intensive care units (PICUs).

Postpartum fevers, a rare presentation of secondary hemophagocytic lymphohistiocytosis.

Iranian journal of immunology : IJI

Variations in Macrophage Activation Syndrome-associated Cardiac Diseases: A Report on Two Cases.

Prognostic value of lipid profile in adult hemophagocytic lymphohistiocytosis.

Frontiers in oncology

Hemophagocytic lymphohistiocytosis in gastric cancer: A rare syndrome for the oncologist. Case report and brief review.

Frontiers in oncology

Severe COVID-19-Induced Hemophagocytic Lymphohistiocytosis.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research

Severe COVID-19-associated hyperinflammatory syndrome versus classic hemophagocytic lymphohistiocytosis: similarities, differences, and the way forward.

Journal of investigative medicine high impact case reports

A Case of Disseminated Histoplasmosis From California, in the Setting of Secondary Hemophagocytic Lymphohistiocytosis: A Diagnostic Challenge.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Acute liver failure and unique challenges of pediatric liver transplantation amidst a worldwide cluster of adenovirus-associated hepatitis.

The journal of the Royal College of Physicians of Edinburgh

Acanthamoeba meningoencephalitis causing secondary hemophagocytic lymphohistiocytosis in an immunocompetent patient: A first case report.

Journal of global infectious diseases

Disseminated Cytomegalovirus Infection in a Child with Langerhans Cell Histiocytosis.

Journal of investigative medicine high impact case reports

Prolonged Thrombocytopenia in a Case of MIS-C in a Vaccinated Child.

Secondary hemophagocytic lymphohistiocytosis due to Heartland virus.

BMJ case reports

Indian journal of pediatrics

Management of Dengue: An Updated Review.

Hemophagocytic Lymphohistiocytosis in a Patient With Post-acute COVID-19 Infection.

Frontiers in pharmacology

Case report: Drug reaction with eosinophilia and systemic symptoms (DRESS)-induced hemophagocytic disorder.

Molecular therapy : the journal of the American Society of Gene Therapy

Secondary hemophagocytic lymphohistiocytosis following Zolgensma therapy: An evolving story on the innate response to systemic gene therapy.

Secondary hemophagocytic lymphohistiocytosis triggered by peripheral T-cell lymphoma: An unusual case report.

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Próxima:Doenças relacionadas

Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Ordenadas pelo número de sintomas em comum.

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39 em comum

ORPHA:158057

Síndrome de ativação macrofágica

29 em comum

ORPHA:158061

Síndrome linfoproliferativo autoimune

26 em comum

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Síndrome JMP

Síndrome Nakajo-Nishimura

ORPHA:324999

ORPHA:2615

Síndrome CANDLE

Síndrome autoinflamatório associado aos proteassomas

ORPHA:325004