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NCT04651439 · Severe Bullous Drug Eruption and FilgrastimRecrutando

PHASE2, PHASE3

NCT06119490 · Evaluation of the Efficacy and Safety of Methylprednisolone …Recrutando

EARLY_PHASE1

Outros ensaios clínicos

41 ensaios clínicos encontrados, 4 ativos.

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NCT07110662 · New Therapeutic Target for Toxic Epidermal Necrolysis (TEN) …Em breve

NCT03585946 · Outcomes in Stevens Johnsons Syndrome and Toxic Epidermal Ne…Cancelado

NCT02987257 · NATIENS: Optimal Management and Mechanisms of SJS/TENConcluído

PHASE3

NCT06474078 · Study To Evaluate The Efficacy Of Tofacitinib In Patients Wi…Concluído

NCT06522048 · SJS/TEN or Other Cutaneous Adverse Eevents Induced by Immune…Concluído

NCT02795143 · Evaluating the Effect of Isotretinoin in Regulatory T-cell F…Cancelado

NCT05320653 · Nutritional and Metabolic Management of Toxidermia Patients …Concluído

NCT05284929 · Human Leukocyte Antigen Class II (DRB1 and DQB1) Alleles and…UNKNOWN

NCT05145959 · Meibomian Gland Probing in the Sub-Acute Phase of Patients W…UNKNOWN

NCT02319616 · Topical Clobetasol for the Treatment of Toxic Epidermal Necr…Cancelado

NCT02574988 · Severe Cutaneous Adverse Reactions in ThailandUNKNOWN

NCT03839069 · Minor Salivary Gland Transplantation for Cicatrizing Conjunc…UNKNOWN

NCT02126020 · Topical Infliximab in Autoimmune Eyes With KeratoprosthesisCancelado

NCT02037347 · Study to Evaluate the Use of Palifermin to Treat Toxic Epide…Encerrado

NCT01696500 · Phase III Clinical Trial of NPB-01 in Patients With Stevens-…Concluído

PHASE3

NCT00372723 · Study of a Potential New Treatment for Patients With Toxic E…Cancelado

PHASE2

Ver todos no ClinicalTrials.gov

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Timeline de publicações

2.542 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 2.542

#1

Ruxolitinib and Tocilizumab for Child Bronchiolitis Obliterans After Toxic Epidermal Necrolysis.

Pediatrics2026 Mar 12

Toxic epidermal necrolysis (TEN) is a life-threatening mucocutaneous disorder with rare but potentially fatal respiratory complications. We present an exceptional documented case of TEN with severe bronchial obstruction successfully treated with tocilizumab and ruxolitinib in an 11-year-old patient. Despite early methylprednisolone pulse therapy, a repeat bronchoscopy showed progressive obstruction of proximal bronchial lumen by synechiae and mucosal membranes. Following multidisciplinary discussion, treatment was intensified with tocilizumab and ruxolitinib, resulting in marked respiratory improvement and decreased proinflammatory cytokines in bronchoalveolar lavage. No adverse effects were observed during 8 months of follow-up. Recent research supports Janus kinase inhibitors as targeted therapy in TEN.

#2

A multidisciplinary, phased nursing strategy for skin and mucosal management in a pediatric case of toxic epidermal necrolysis with respiratory failure: a case report.

Frontiers in pediatrics2026

Toxic Epidermal Necrolysis (TEN) is a life-threatening dermatologic emergency, with particularly high morbidity and mortality in children due to their vulnerable skin barrier and propensity for systemic complications. When TEN is further complicated by respiratory failure, the competing demands of airway management and skin preservation pose a significant therapeutic challenge. We report a case of a 6-year-old boy with TEN involving 70% body surface area and concurrent respiratory failure. The patient required endotracheal intubation and mechanical ventilation, which exacerbated facial skin injury. A structured, multidisciplinary, and phased nursing protocol was implemented, integrating respiratory support with meticulous skin, ocular, oral, and urogenital care. A coordinated team comprising pediatric intensive care, dermatology, infectious diseases, and nutrition specialists guided management. Skin care was staged according to wound healing phases, utilizing non-adhesive dressings, topical recombinant bovine basic fibroblast growth factor (bFGF) gel, and innovative tube-securement techniques. Systemic and mucosal care protocols were rigorously applied. The patient achieved complete re-epithelialization by day 35, was successfully extubated, and discharged in stable condition on day 46 with no major sequelae. This case demonstrates that a structured, phase-based, and multidisciplinary nursing approach can effectively balance life-sustaining interventions with tissue preservation in severe pediatric TEN. The strategy highlights the importance of adaptive wound staging, trauma-minimizing techniques, and proactive mucosal protection, offering a replicable framework for similar critical care scenarios.

#3

A case of Stevens-Johnson syndrome triggered by Mycoplasma infection.

Journal of oral science2026

Stevens-Johnson syndrome (SJS) is a rare, potentially life-threatening mucocutaneous disorder, which is often triggered by infections such as Mycoplasma pneumoniae. This report describes a 19-year-old woman who initially presented with oral erosions and painful blisters, along with fever and cough. Oral lesions preceded skin and ocular involvement, and tests confirmed Mycoplasma-associated SJS. She responded to steroid pulse therapy but relapsed at 3 months and was then successfully treated. Oral manifestations may be early SJS indicators; thus, prompt recognition and interdisciplinary care by oral health professionals are vital for improving clinical outcomes.

#4

Validation of International Classification of Diseases Codes for Dermatologic Conditions: A Systematic Review.

JAMA dermatology2026 Feb 01

Accurate classification of dermatologic conditions using International Classification of Diseases (ICD) codes is essential for research that uses large administrative datasets. Misclassification can be associated with biased epidemiologic estimates and misleading conclusions in population-based studies. To systematically identify and evaluate validated classification approaches for dermatologic conditions using ICD codes in US-based administrative, claims, or electronic health record data. A systematic review was conducted that was registered with PROSPERO (CRD420250654233) and reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive search of Ovid MEDLINE, Embase, Web of Science, and CINAHL was conducted for studies published from January 1, 2000, to October 21, 2025. The data were analyzed in October 2025. Eligible studies evaluated International Classification of Diseases, Ninth Revision (ICD-9) or International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) codes used to identify dermatologic conditions in US-based datasets and reported at least 1 classification metric (eg, positive predictive value). To minimize selection and extraction bias, all screening and data extraction were performed independently by 2 reviewers, with discrepancies resolved by consensus. A total of 59 studies met inclusion criteria. Most reported positive predictive value, with few reporting sensitivity or specificity. Classification accuracy varied widely by condition and coding strategy. Studies included inflammatory and autoimmune conditions (eg, acne vulgaris, perioral dermatitis, psoriasis, palmoplantar pustulosis, hidradenitis suppurativa, atopic dermatitis, prurigo nodularis, dermatomyositis, cutaneous lupus erythematosus, pyoderma gangrenosum, cutaneous sarcoidosis, pemphigus, pemphigoid, granuloma annulare, alopecia areata, and vitiligo), actinic keratosis and skin cancer, pigmentary and hair disorders (eg, androgenic alopecia, cicatricial alopecia, lichen planopilaris, and melasma), drug reactions (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis), and infections (eg, herpes zoster, herpes simplex virus, and cellulitis or abscess). Classification algorithms that incorporated 2 or more codes, dermatologist attribution, or treatment/procedural data often achieved the highest accuracy. Conditions lacking validated algorithms included seborrheic dermatitis, rosacea, fungal infections, and specific alopecia subtypes. This systematic review provides a summary of the most accurate classification approaches to identify various dermatologic conditions in large administrative datasets. These results may inform study designs when using these datasets. In addition, some common conditions lack validated classification approaches, highlighting important areas for future research. As administrative and electronic health record data increasingly support dermatology research, use of rigorously validated algorithms will be essential for generating trustworthy findings.

#5

Recovering From Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

JAMA dermatology2026 Jan 01

Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) survivors experience substantial long-term sequelae. Research on physical symptoms experienced during acute hospitalization is well documented, but limited studies have been completed on the long-term biopsychosocial effects of SJS/TEN, particularly from the patient's perspective. To increase the understanding of the long-term complications of SJS/TEN. This qualitative investigation was completed from within a community-based study, the SJS Survivors Study, using a semistructured, in-depth interview guide to query participants about their SJS/TEN experience postdischarge from the hospital. Interviews took place by phone from July 2021 through August 2023. This study included adults who experienced SJS/TEN within the United States. A biopsychosocial theory-based framework and hierarchical coding system were utilized to understand the long-term life impacts of survivors of SJS/TEN. The 29 participants, aged 26 to 76 years, were 66% female and 69% White and had experienced SJS/TEN from a wide range of drugs. Patients experienced support while in the hospital, but once discharged, felt isolated and without support to understand the potential sustained impacts of SJS/TEN in their lives and the lives of their family members. Patients experienced ongoing biological symptoms, such as skin issues, debilitating visual impairment, blindness, and lack of functional autonomy. Psychological impacts included symptoms of anxiety, obsessive thinking, flashbacks, and depression. Socially, some survivors expressed a sense of abandonment and described negative impacts on their careers. Survivors also expressed frustration and isolation with having to navigate posthospital care alone. There was a lack of preemptive discharge education and SJS/TEN-specific planning. Lack of physician knowledge about SJS/TEN was particularly noted and survivors turned to the internet for guidance instead of receiving direction from their physicians. Medical distrust among survivors was frequently noted. The findings highlight the need for postdischarge care coordination among patients and their primary physicians, including mental health support. This care coordination should be arranged prior to discharge to ensure the availability of adequate support and optimal health outcomes. It is essential that clinicians and researchers prioritize the understanding of long-term sequelae of SJS/TEN and improve current discharge education and protocols for patients and their families.

Publicações recentes

Treatment of toxic epidermal necrolysis in a patient with extensive skin damage induced by dimethyl N-cyanodithioiminocarbonate: a case report.

Front Allergy2026

Suspected Stevens-Johnson Syndrome After Azithromycin and Doxycycline Exposure in an Elderly Woman: A Case Report Showcasing Treatment Based on Clinical Diagnosis.

Cureus2026 Mar

Stevens-Johnson Syndrome following a Single Ampicillin Dose in an Elderly Patient: A Case Report.

Case Rep Dermatol2026 Jan-Dec

[DIAGNOSIS AND MANAGEMENT OF SEVERE CUTANEOUS ADVERSE DRUG REACTIONS].

🥈 Observacional

Arerugi2026

Plasma Cytokine and Chemokine Profile in Hospitalized Toxic Epidermal Necrolysis Patients.

🥇 Meta-análise

Clin Exp Dermatol2026 Apr 9

Ver todas no PubMed

📚 EuropePMC3.186 artigos no totalmostrando 198

A Case of Toxic Epidermal Necrolysis-Like Dermatosis Associated With Contact Exposure to a Flurbiprofen Plaster.

The Hidden Perils of Allopurinol: A Systematic Review of Allopurinol-Induced DRESS (Drug Reaction With Eosinophilia and Systemic Symptoms) Syndrome.

A Rash Decision: Mycoplasma-Induced Mucositis in a Young Adult.

Sintilimab-induced toxic epidermal necrolysis complicated in advanced gastric cancer: a case report and literature review.

Involvement of B Cell Subsets in Patients With Steven Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN).

Allergy

Beyond the Target: Re-Emergence of Mycoplasma pneumoniae Supports Reclassification of Adult Mucocutaneous Eruptions.

Ruxolitinib and Tocilizumab for Child Bronchiolitis Obliterans After Toxic Epidermal Necrolysis.

Pediatrics

SEVERE TOXIC EPIDERMAL NECROLYSIS COMPLICATED BY ACUTE KIDNEY INJURY: DIAGNOSTIC AND THERAPEUTIC CONSIDERATIONS.

Georgian medical news

Toxic epidermal necrolysis in a preschooler associated with adenovirus respiratory infection: A case report.

SCORTEN and Novel Prognostic Markers in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Systematic Review and Meta-Analysis.

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review of Cases Secondary to Topical Medications.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

Cutaneous and non-cutaneous diseases due to Mycoplasma pneumoniae in children.

Journal of burn care & research : official publication of the American Burn Association

Predictors of Survival and Length of Stay in Steven Johnson syndrome and toxic epidermal necrolysis: A single centre retrospective study of 111 patients.

Annals of burns and fire disasters

[Toxic Epidermal Necrolysis: Study of an 81-case Series].

Case Report: A case of toxic epidermal necrolysis induced by serplulimab: integrated Chinese and Western nursing care.

Prediction of antibiotic-associated cutaneous adverse drug reactions using electronic health record foundation models.

NPJ digital medicine

International archives of allergy and immunology

A narrative review of drug-induced haemophagocytic lymphohistiocytosis: A rare but relevant differential diagnosis.

The Journal of dermatological treatment

Soluble Fas Ligand, an overlooked target of therapy in dermatological and non-dermatological conditions.

The World Allergy Organization journal

Evaluation of drug causality in SJS/TEN: The role of the lymphocyte transformation test and conventional/modified IFN-γ ELISpot assays.

Indian journal of pharmacology

A rare drug reaction: Toxic epidermal necrolysis following polymyxin B administration in a post-Bentall procedure.

American journal of therapeutics

Tislelizumab-Associated Toxic Epidermal Necrolysis.

Indian dermatology online journal

Rechallenge with First-Line Anti-Tubercular Therapy After Toxic Epidermal Necrolysis in an HIV-Positive Patient with Tubercular Pleural Effusion.

The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians

Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis Possibly Related to Daptomycin And Ceftaroline in a Patient With Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia: A Case Report and Brief Review.

Clinical and experimental dermatology

The effect of different therapies and complete blood cell count-derived inflammatory biomarkers on the prognosis of Stevens-Johnson syndrome and toxic epidermal necrolysis.

A 10-Year Retrospective Cohort Study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis at the Royal Brisbane and Women's Hospital.

Italian journal of dermatology and venereology

Toxic epidermal necrolysis induced by lamotrigine with suspected venlafaxine-related relapse.

Journal of burn care & research : official publication of the American Burn Association

Extracorporeal Membrane Oxygenation Therapy in Toxic Epidermal Necrolysis-Related Respiratory Failure: A Case Report.

Stevens-Johnson syndrome/toxic epidermal necrolysis induced by sintilimab in a patient with advanced non-small cell lung cancer: A case report.

Indian dermatology online journal

Insights into Severe Cutaneous Adverse Drug Reactions: A 5-Year Retrospective Analysis of Stevens- Johnson Syndrome- Toxic Epidermal Necrolysis and Drug Rash with Eosinophilia and Systemic Symptoms.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

Toxic epidermal necrolysis during chemo-immunotherapy treatment with pembrolizumab.

Cancer management and research

Toxic Epidermal Necrolysis in a Patient with Hepatocellular Carcinoma Receiving Pembrolizumab Plus Regorafenib: A Case Report.

Journal of biochemical and molecular toxicology

Molecular Insights Into TNF-α and IFN-γ-Induced Epithelial Cell Death in Toxic Epidermal Necrolysis.

The International journal of risk & safety in medicine

A case of delayed-onset Stevens-Johnson syndrome following co-amoxiclav administration in a 98-year-old female.

Diagnosis and Management of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Pediatric Patients: A Systematic Review of Clinical Guidelines and Consensus Statements.

Pediatric dermatology

Radiologie (Heidelberg, Germany)

[Drug-induced hypersensitivity reactions : Pulmonary manifestations and radiological characteristics].

Toxic Epidermal Necrolysis in Pregnancy: A Case Report.

Case Report: Toxic epidermal necrolysis induced by sintilimab in a patient with advanced lung squamous cell carcinoma.

Evaluating Pharmacogenomic Prescription Data in the Military Health System.

Military medicine

A case of toxic epidermal necrolysis associated with vonoprazan, a potassium-competitive acid blocker.

Nimesulide-Associated Generalized Bullous Fixed Drug Eruption: A Rare Pharmacovigilance Case Report.

Annals of medicine and surgery (2012)

JAK inhibitors in toxic epidermal necrolysis a new frontier in therapeutics.

American journal of therapeutics

Envafolimab-Associated Toxic Epidermal Necrolysis.

Factors associated with penicillin and sulfonamide allergy and Stevens-Johnson syndrome/toxic epidermal necrolysis.

AIDS (London, England)

Racial Disparities in Severe Cutaneous Adverse Reactions: A Report of Two Cases on Preventable Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Prescription Errors Through Medication Stewardship.

Journal of surgical case reports

Treatment of toxic epidermal necrosis lesions with ovine forestomach matrix.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

Toxic epidermal necrolysis associated with immune checkpoint inhibitors for bladder cancer: A case report.

British journal of clinical pharmacology

Cyclosporine use in paediatric dermatologic conditions: A comprehensive review of therapeutic applications.

A multidisciplinary, phased nursing strategy for skin and mucosal management in a pediatric case of toxic epidermal necrolysis with respiratory failure: a case report.

Frontiers in pediatrics

The British journal of dermatology

Development of a health-related quality of life outcome measure for adults with Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) - QoLTEN: An international multidisciplinary DELPHI consensus survey.

Effective management of pembrolizumab-induced Stevens-Johnson syndrome/toxic epidermal necrolysis overlap with upadacitinib.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

Zinc supplement: A rare cause of toxic epidermal necrolysis in a pediatric patient.

Journal of burn care & research : official publication of the American Burn Association

The Outcomes of SJS/TEN: A Nationwide Analysis.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Diagnosis and treatment of cutaneous adverse effects of targeted therapy, antibody-drug conjugates, and immunotherapy in cancer patients: a national consensus statement by the Spanish Society of Medical Oncology and the Spanish Academy of Dermatology and Venereology.

Predictive value of a severity-of-illness score for toxic epidermal necrolysis (SCORTEN) factors for in-hospital mortality in Stevens-Johnson syndrome/toxic epidermal necrolysis.

Immune checkpoint inhibitor-related Stevens-Johnson syndrome and toxic epidermal necrolysis: a retrospective analysis of 21 cases.

Pharmaceuticals (Basel, Switzerland)

Real-World Data on Severe Cutaneous Adverse Reactions to Drugs.

International journal of clinical pharmacology and therapeutics

Epidemiological characteristics of severe skin adverse reactions caused by immune checkpoint inhibitors based on case reports.

The journal of allergy and clinical immunology. In practice

Evidence of a Therapeutic Window for TNF-α Inhibitor and Intravenous Immunoglobulin Benefits in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Treatment: A Multicenter 6-Year Retrospective Study.

Spectrum mining of immune checkpoint inhibitor-related cutaneous toxicities and analysis of associated factors based on FAERS.

Early-onset fatal toxic epidermal necrolysis after first-cycle enfortumab vedotin in an elderly patient with metastatic urothelial carcinoma.

Urology case reports

SAGE open medical case reports

Stevens-Johnson syndrome/toxic epidermal necrolysis as the initial presentation of paraneoplastic anti-TIF1-γ dermatomyositis.

A case of Stevens-Johnson syndrome triggered by Mycoplasma infection.

Journal of oral science

Gan to kagaku ryoho. Cancer & chemotherapy

[A Case of Toxic Epidermal Necrolysis during Chemotherapy for Advanced Gastric Cancer].

Clinicopathologic and Immunohistochemical Features of Enfortumab Vedotin-Induced Cutaneous Toxicity.

The journal of allergy and clinical immunology. In practice

Generalized Bullous Fixed Drug Eruption: A Systematic Review.

Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne

Microbiological findings and antimicrobial resistance dynamics in pathogens isolated from patients with toxic epidermal necrolysis: a single center experience.

Journal of dermatological science

Comparative analysis of cytotoxic mediators in Stevens-Johnson syndrome and toxic epidermal necrolysis using ex vivo human epidermis.

Outcome of sutureless amniotic membrane dressing ring for acute Stevens-Johnson syndrome with severe ocular involvement: A case report of 5 patients.

Journal of clinical medicine

Toxic Epidermal Necrolysis and Steven-Johnson Syndrome During the Postpartum Period: A Literature Review with a Rare Case Presentation.

Dermatologie (Heidelberg, Germany)

[Atypical manifestation of bullous, multifocal erysipelas on the trunk-case report].

Guidelines for the Management of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis 2025 Supplement.

Validation of International Classification of Diseases Codes for Dermatologic Conditions: A Systematic Review.

JAMA dermatology

Just the facts: diagnosis and management of Stevens-Johnson syndrome/toxic epidermal necrolysis.

CJEM

Recent advances in inflammation & allergy drug discovery

IL-6 as a Potential Sensitive Serum Biomarker in Stevens-johnson Syndrome/Toxic Epidermal Necrolysis: Two Case Reports.

The journal of allergy and clinical immunology. In practice

Blistering Drug Eruptions: Diagnostic Challenges and Management in Clinical Practice: Unmasking the Cause: A Grand Rounds Review of Blistering Drug Eruption.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Risk factors and predictive score for phenytoin-induced cutaneous reactions.

Journal of the European Academy of Dermatology and Venereology : JEADV

A scoping review of case reports and small case series in Stevens-Johnson syndrome/toxic epidermal necrolysis.

Severe Cutaneous Signs of Hipersensitivity to Drugs in a Pediatric Hospital.

Reactive Infectious Mucocutaneous Eruption Following Isolated Rhinovirus Infection: Clinical Presentation and Treatment Response.

A Fatal Case of Enfortumab Vedotin-Caused Cutaneous Adverse Reaction Mimicking Toxic Epidermal Necrolysis With Myelosuppression: Distinct Clinical and Histopathological Features.

The Predictive Value of Inflammatory Markers in the Severity and Mortality Risk of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.

Human Amniotic Membrane Grafting for the Management of Toxic Epidermal Necrolysis.

Toxic Epidermal Necrolysis Due to Pembrolizumab-Associated Chemotherapy.

Increased TNF-α in SJS/TEN induced by PD-1 inhibitors supports the combination therapy of etanercept and systemic corticosteroids.

Molecular immunology

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

Delayed presentation of pembrolizumab-induced SJS-TEN overlap syndrome.

Italian journal of dermatology and venereology

Cheilitis: a comprehensive review and a new clinical classification proposal. Part 1: Isolated cheilitis.

[Clinical Approach to the Patient With Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Part II].

Revista medica de Chile

Evidence for the Use of Janus Kinase (JAK) Inhibitors in the Management of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Scoping Review.

The Korean journal of helicobacter and upper gastrointestinal research

Toxic Epidermal Necrolysis Induced by First-Line Helicobacter pylori Eradication Therapy: A Case Report.

Paediatric Stevens-Johnson syndrome and toxic epidermal necrolysis: patterns and outcomes in a retrospective Pakistani cohort.

BMJ paediatrics open

Chronic Ocular Complications in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: Clinical Features and Surgical Management in a Brazilian Tertiary Center.

Cornea

Ocular administration of brinzolamide leading to Stevens-Johnson syndrome/toxic epidermal necrolysis overlap: A case report and review.

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Induced by Topical Carbonic Anhydrase Inhibitors: A Literature Review.

Diagnostic sensitivity and specificity of mucosal involvement versus skin biopsy for Stevens-Johnson syndrome/toxic epidermal necrolysis.

Clinical and translational science

Cutaneous Adverse Effects of EGFR Therapy in Breast Cancer Treatment.

Stevens-Johnson syndrome/toxic epidermal necrolysis induced by tislelizumab: a case report and literature review.

International journal of clinical pharmacy

Severe cutaneous adverse reactions linked to medications in children and adolescents: a pharmacovigilance study based on the FDA Adverse Event Reporting System database.

International journal of surgery case reports

Severe cutaneous adverse reaction to amoxicillin-clavulanate: Pediatric toxic epidermal necrolysis in the Gulf: A case report and literature review.

The Medical journal of Malaysia

Incidence and clinical patterns, severity and preventability of cutaneous adverse drug reactions among hospitalized patients in a tertiary centre.

Italian journal of dermatology and venereology

Cheilitis: a comprehensive review and a new clinical classification proposal. Part 2: Cheilitis associated with dermatological diseases, systemic diseases, or drug reactions.

Overlap of Toxic Epidermal Necrolysis (TEN)-Like Cutaneous Lupus and Rowell Syndrome in Systemic Lupus Erythematosus: A Case-Based Review.

Bioinformatics analysis of Rickettsia typhi autoimmune associations and screening of Streptomyces-derived inhibitors.

BioData mining

Case Report: Zonisamide-induced DRESS syndrome with progression toward SJS: the first Chinese case and review of the literature on ZNS-associated SCARs.

Pediatrics international : official journal of the Japan Pediatric Society

Examination of histopathological findings in Mycoplasma pneumoniae-induced rash and mucositis case.

Comparative Impact of NSAIDs Versus Acetaminophen on Mortality in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Retrospective Cohort Study of 2484 Patients From a Nationwide Inpatient Database.

Journal of cutaneous pathology

Mycoplasma pneumoniae-Induced Rash and Mucositis: Clinicopathologic Characterization of 11 Cases.

Umbilical cord-derived mesenchymal stem cell therapy for acute Stevens-Johnson syndrome/Toxic Epidermal Necrolysis with severe ocular involvement.

Indian journal of ophthalmology

Ocular involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis: A review of current management and changing trends.

Presse medicale (Paris, France : 1983)

Update on dermatological toxicities of immune checkpoint inhibitors.

Archives of pathology & laboratory medicine

Immune Checkpoint Inhibitor-Related Epidermal Necrosis: Terminology, Pathology, and Clinical Implications.

PCN reports : psychiatry and clinical neurosciences

Cost-effectiveness analysis of pharmacogenetic-guided antiseizure medication therapy based on the risk of HLA-A*31:01 allele variants in Japan.

Cutaneous and ocular toxicology

Analysis of clinical characteristics of tislelizumab-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in the Chinese population: a systematic review.

Basic & clinical pharmacology & toxicology

Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Associated With Mebendazole Use.

Tislelizumab-associated toxic epidermal necrolysis in an esophageal cancer patient: a case report.

Recognition of Diffuse Pustules and Hemorrhagic Crusts as Early Warning Signs of Invasive Candidiasis in a Patient With Toxic Epidermal Necrolysis.

Clinical case reports

Journal of clinical and experimental dentistry

Management of oral lesions in toxic epidermal necrolysis with photobiomodulation: Report of three cases.

Pharmacoepidemiology and drug safety

Titel: Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Among Patients Treated With Immune Checkpoint Inhibitors Compared to Other Antineoplastic Medications: A Nationwide Study.

Apalutamide-induced life-threatening dermatologic toxicity: Clinical histopathological correlations and salvage therapies in four cases: Case report series.

Improving identification of SJS/TEN and its mimics across a large geographic area: Outcomes from a novel telemedicine collaboration.

Recovering From Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

JAMA dermatology

Etoricoxib and its hidden risks: a case-based review of dermatological, hematological, and cardiovascular complications.

EXCLI journal

Allergology international : official journal of the Japanese Society of Allergology

Cytokine profile-guided management of Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN): A management algorithm useful for guiding the selection of treatment options.

Hypoalbuminemia and Nutritional Status in Docetaxel-Induced Erythema Multiforme: A Case Report.

Annales de dermatologie et de venereologie

Skin-adverse drug reactions in the elderly: An underestimated and avoidable issue.

Paediatrics and international child health

Severe pneumonia with Mycoplasma pneumoniae-induced raѕh and mucositis in an 8-year-old boy.

Romanian journal of ophthalmology

Surgery for Symblepharon Developed Due to Stevens-Johnson Syndrome: Modified Ring Procedure Performed Through Amniotic Membrane Transplantation and a 6 French Aspiration Catheter.

Stevens-Johnson syndrome or toxic epidermal necrolysis from antihypertensive medications: A systematic review of cases.

Anais brasileiros de dermatologia

Low-level laser therapy for the treatment of oral manifestations in a patient with toxic epidermal necrolysis: a case report.

Post-market surveillance data demonstrate high mortality associated with enfortumab vedotin skin toxicity, not worsened by immune checkpoint inhibitors or corticosteroids.

An Atypical Case of Toxic Epidermal Necrolysis Associated With Ceftriaxone.

Pediatric vs adult Stevens Johnson syndrome/toxic epidermal necrolysis: Ocular outcomes and the role of amniotic membrane.

Psychological Complications of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review and Meta-Analysis.

Journal of pharmaceutical health care and sciences

Ofloxacin, paracetamol and cefixime induced Stevens-Johnson syndrome - toxic epidermal necrolysis in an adult female patient: a case report.

JAAD Game Changer: Retrospective cohort study characterizing PD-1/PD-L1 checkpoint inhibition associated Stevens-Johnson syndrome and toxic epidermal necrolysis.

Immune Checkpoint Inhibitors as Independent and Synergistic Drivers of SJS/TEN.

JAMA oncology

Journal of the European Academy of Dermatology and Venereology : JEADV

Prevention and management of cutaneous immune-related adverse events: EADV Task Force statement.

Ocular manifestations in Stevens‒Johnson syndrome/toxic epidermal necrolysis in cancer patients.

HLA-B*58:01 and Risk of Allopurinol-Induced Severe Cutaneous Adverse Reactions in the US.

JAMA dermatology

Advances in skin & wound care

Summary of the Best Evidence on Skin-Mucosal Care in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.

Allergy and asthma proceedings

Evaluation of diagnostic tests for suspected hypersensitivity reactions to proton pump inhibitors in children.

Toxic Epidermal Necrolysis and Mortality: A Danish Cohort Study With 30 Years of Follow-Up.

Polish archives of internal medicine

Toxic epidermal necrolysis as a rare complication of pembrolizumab immunotherapy in the treatment of squamous cell lung cancer.

The Kaohsiung journal of medical sciences

Fatal Pembrolizumab-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis in a Patient With Advanced Lung Adenocarcinoma.

Dermatologie (Heidelberg, Germany)

[Current dermatology guidelines in Germany: a selection of clinically relevant recommendations].

High serum unconjugated bilirubin levels following successful treatment of antiepileptic drug-induced bullosa epidermolysis: a case report and review of the literature.

Biologic therapies for dermatologic emergencies: A comprehensive review.

Long-term cardiovascular morbidity in Stevens-Johnson syndrome: A retrospective TriNetX matched-cohort analysis.

Pediatric Mycoplasma pneumoniae-induced rash and mucositis in China: clinical spectrum, co-infections and risk factors for recurrence-a retrospective cohort study.

Frontiers in allergy

Seminars in ophthalmology

Unravelling Stevens-Johnson Syndrome: Clinicopathological Insights and Therapeutic Advances.

Amniotic membrane transplantation techniques in acute ocular Stevens-Johnson syndrome and toxic epidermal necrolysis: A systematic review.

Ocular immunology and inflammation

Relationship Between Chronic Ocular Surface and Meibomian Gland Changes and Clinical Assessment Tool in Cicatricial Conjunctival Diseases.

Toxic Epidermal Necrolysis and Recurrent Implantation Failure: Unveiling a Rare Phenomenon During Pregnancy.

Clinical case reports

Epidermal necrolysis (Stevens-Johnson syndrome/ toxic epidermal necrolysis) as extensive boundary violation: A qualitative study on the illness experience and care needs of survivors in the context of the first German guideline.

PloS one

[A CASE OF PEDIATRITIC TOXIC EPIDERMAL NECROSIS TRIGGERD BY OVER-THE-COUNTER EYE DROPS].

Arerugi = [Allergy]

Stevens-Johnson syndrome-toxic epidermal necrolysis spectrum reactions to immune checkpoint inhibitor therapy and safety of rechallenge: A retrospective review.

European annals of otorhinolaryngology, head and neck diseases

Extensive upper aerodigestive tract involvement in metamizole-induced Stevens-Johnson syndrome/toxic epidermal necrolysis.

Pediatric Stevens-Johnson syndrome and toxic epidermal necrolysis: age-stratified insights from the FAERS database.

Jornal de pediatria

Japanese journal of ophthalmology

Clinical course and efficacy of treatment with limbal-rigid contact lens wear for ocular sequelae in Stevens-Johnson syndrome/toxic epidermal necrolysis.

Biomedica : revista del Instituto Nacional de Salud

Multidisciplinary management of antiepileptic drug-induced toxic epidermal necrolysis in a young woman.

Virchows Archiv : an international journal of pathology

Myeloperoxidase-positive mononuclear cells predominate over CD3-positive T-lymphocytes in the epidermis of Stevens-Johnson syndrome and toxic epidermal necrolysis.

Clinical Outcomes of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Based on Hospital Admission Type.

Cutis

Advancing drug safety in psychiatry: insights from pharmacogenomics of hypersensitivity reactions.

Clinicopathological challenges of diagnosing reactive infectious mucocutaneous eruption.

BMJ case reports

Structured skin care for a patient with toxic epidermal necrolysis caused by anlotinib: Case report.

Inhibition of formyl peptide receptor-1-mediated cell death as a therapy for lethal cutaneous drug reactions in preclinical models.

Nature communications

Annals of agricultural and environmental medicine : AAEM

Difficulties in management of ocular surface in the late phase of toxic epidermal necrolysis - a rare case report.

Clinical, pathological and immunological features of toxic-epidermal necrolysis like lupus erythematosus: A systematic review and proposal for diagnostic criteria.

Lupus

Acta dermatovenerologica Alpina, Pannonica, et Adriatica

Toxic epidermal necrolysis: lessons from three fatal cases.

The British journal of dermatology

Long-term morbidity and quality of life in survivors of Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum.

Successful rescue of PD-1 inhibitor-induced TEN by vincristine combination therapy: a case report and literature review.

Frontiers in oncology

Stevens-Johnson syndrome/toxic epidermal necrolysis-like acute cutaneous lupus erythematosus.

Medicina clinica

Immune checkpoint inhibitor-induced toxic epidermal necrolysis responding to repeated dosing of adjuvant therapy with etanercept.

European journal of human genetics : EJHG

Pharmacogenomics in drug therapy: global regulatory guidelines for managing high-risk drug reactions.

Vision (Basel, Switzerland)

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review of Ophthalmic Management and Treatment.

Vulvovaginal involvement in Stevens-Johnson syndrome/toxic epidermal necrolysis: A retrospective review at a tertiary care center (2016-2024).

Journal of inflammation research

Viral Triggers Exposed: A Systematic Review of Virus-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.

Toxic Epidermal Necrolysis-Like Syndrome Following CAR-T Therapy: A Case Report and Review of Distinctive Clinical Features.

Photodermatology, photoimmunology & photomedicine

Photodistributed Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

Cyclosporine: An Emerging Therapeutic Agent for<br /> Paediatric Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

Fatal Toxic Epidermal Necrolysis-Like Lupus Erythematosus in a Patient With Metastatic Histiocytic Sarcoma.

Emerging causes of anticancer therapies-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: evidence from disproportionality analysis of the FDA adverse event reporting system.

Clinical, cosmetic and investigational dermatology

Case Report: Pirfenidone-Induced Toxic Epidermal Necrolysisa a Rare Idiosyncratic Reaction.

Internal medicine (Tokyo, Japan)

A Case of Acetaminophen-induced Toxic Epidermal Necrolysis with Airway Mucosal Lesions.

Toxic epidermal necrolysis-like subacute cutaneous lupus erythematosus following pembrolizumab therapy.

Azithromycin-Induced Stevens-Johnson Syndrome in a Patient With SARS-CoV-2 and End-Stage Renal Disease.

Drug-Induced Toxic Epidermal Necrolysis: A Case Report.

Toxicology and applied pharmacology

All-trans retinoic acid exacerbates Stevens-Johnson syndrome and toxic epidermal necrolysis via TNF signaling pathways: A network toxicology, molecular docking, and experimental study.

The Journal of investigative dermatology

Analysis of Skin Immune Cells in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

Systemic immunomodulating therapies for epidermal necrolysis (Stevens-Johnson syndrome/toxic epidermal necrolysis): A systematic review and meta-analysis.

Annals of medicine and surgery (2012)

Cefuroxime-induced toxic epidermal necrolysis in a 4-year-old male child: a case report.

European urology open science

One Man's Meat Is Another Man's Poison: High Incidence of Severe Cutaneous Drug Reactions Induced by Enfortumab Vedotin.

medRxiv : the preprint server for health sciences

Seasonality and Trends in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Before and During the COVID-19 Pandemic: A Pharmacovigilance Study.

Ibuprofen-Induced Toxic Epidermal Necrolysis: Report of a Fatal Case.

Role of pharmacogenomics for prevention of hypersensitivity reactions induced by aromatic antiseizure medications.

Internal medicine (Tokyo, Japan)

Bloodstream Infection Caused by Mycobacterium neoaurum in a Primary Central Nervous System Lymphoma Patient with Toxic Epidermal Necrolysis.

Seminars in ophthalmology

Ocular Complications in stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Comprehensive Review.

Adult Case of Toxic Erythema of Chemotherapy Mimicking Toxic Epidermal Necrolysis in a Patient on Enfortumab Vedotin and Pembrolizumab.

Mayo Clinic proceedings