Poliomielite

Phase IV Clinical Study of Sequential Vaccination of Sabin Strain and Wild Strain Inactivated Poliovirus Vaccine

NCT07457060

Phase IV Clinical Study of sIPV Administration in Adolescent and Adult Populations

NCT07354269

Study of Co-administered (Types 1 & 2) Novel Oral Poliomyelitis Vaccines Evaluation

NCT06895486

Study of a Novel Type 1 Oral Poliomyelitis Vaccine in Bangladesh

NCT05644184

A Study to Evaluate the Safety and Immunogenicity of VLP-Polio in Infants and Toddlers

Fase II

NCT06577298

NCT07457060 · Phase IV Clinical Study of Sequential Vaccination of Sabin S…Recrutando

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NCT07354269 · Phase IV Clinical Study of sIPV Administration in Adolescent…Recrutando

NCT06895486 · Study of Co-administered (Types 1 & 2) Novel Oral Poliomyeli…Recrutando

PHASE2

NCT05644184 · Study of a Novel Type 1 Oral Poliomyelitis Vaccine in Bangla…Recrutando

PHASE2

NCT06577298 · A Study to Evaluate the Safety and Immunogenicity of VLP-Pol…Recrutando

PHASE1, PHASE2

NCT06947499 · A Phase II/III Study to Evaluate the Immunogenicity, Safety …Recrutando

PHASE2, PHASE3

NCT06137664 · Study of Trivalent and Bivalent (Types 1 & 2) Novel Oral Pol…Recrutando

PHASE1, PHASE2

NCT06605755 · Safety and Immunogenicity of DTaP-IPV/Hib Pentavalent Vaccin…Recrutando

NCT02089880 · Comparing Functional Outcomes in Individuals Using Micro-pro…Ativo

Outros ensaios clínicos

317 ensaios clínicos encontrados, 16 ativos.

Distribuição por fase

NCT06218368 · A Tool Kit to Improve Vaccine Confidence in the PhilippinesAtivo

NCT07338851 · the Five-year Antibody Persistence After Immunization With I…Em breve

NCT07010822 · A Study to Evaluate the Mucosal Intestinal Immunity to Polio…Em breve

PHASE3

NCT06920069 · Study of Concomitant Administration of the sIPV and DTaP or …Em breve

NCT06748612 · Immunogenicity of Different Primary Immunization Schedules w…Em breve

NCT06618196 · Study to Evaluate the Immunogenicity of LR20062 Compared to …Em breve

PHASE2

NCT06460545 · Phase IV Study of Concomitant Administration of the sIPV and…Em breve

NCT07073144 · The Impact of 'Digital Strolling' on Depression and Quality …Concluído

NCT06442449 · Booster Dose of sIPV Co-administered With MMR and HepA-I.Concluído

NCT03891758 · Confirmatory Study of BK1310 in Healthy InfantsConcluído

PHASE3

NCT07297186 · Phase III Clinical Trial of Sabin Strain Inactivated Poliovi…Concluído

PHASE3

Ver todos no ClinicalTrials.gov

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Publicações mais relevantes

Timeline de publicações

1.514 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 1.514

#1

Estimating population immunity against serotype-two poliomyelitis from the inactivated polio vaccine in routine immunization across 112 countries: A modelling study.

PLoS medicine2026 Mar

To mitigate the risk of outbreaks of serotype 2 poliomyelitis after withdrawal of this serotype from oral poliovirus vaccine (OPV) in 2016, inactivated poliovirus vaccine (IPV) was introduced into the routine immunization (RI) programmes of all countries using OPV. Since 2022, WHO has recommended a 2-dose schedule, with a first dose at 14 weeks of age followed by a second dose at least 4 months later (e.g., 14-39 week schedule), although an earlier schedule may be adopted, despite lower immunogenicity, if vaccine coverage is low at older ages. We combined published data on type-2 IPV seroconversion with age, national RI coverage estimates, dose introduction dates, and country-specific schedules using a cohort model of population immunity to estimate IPV-induced immunity from 2024-2031 for 112 countries using either one or two doses of IPV. We projected immunity for current, 6-14, and 14-39 week schedules to find the optimal schedule and estimate the impact of interventions such as schedule changes and catch-ups. Under current schedules, estimated median serotype 2 population immunity in 2025 among children under five years of age is at 61% (IQR: 52%, 72%), rising to 71% (IQR: 57%, 80%) in 2031. The later 14-39 week schedule was optimal in all countries, with potential for the median immunity to rise to 78% (IQR: 66%, 85%) by 2031 if adopted by all countries in 2026. Eight countries would still have <50% immunity, rising to 65%-72% if catch-up campaigns with 80% coverage were implemented in 2030. The work is limited by the fact that IPV provides only a partial picture of total immunity where there has been emergency type-2 OPV use. Furthermore, national estimates may mask subnational coverage differences and pockets of extremely low immunity. Under these estimates, IPV schedules and coverage are suboptimal in many countries. Those with a single dose should introduce a second on the 14-39 week schedule; those on early schedules would benefit from adopting the 14-39 week schedule. IPV catch-up campaigns are recommended where RI coverage is low.

#2

Leveraging community insights and navigating logistical challenges: a case study of the 2024 polio vaccination campaign in Gaza, State of Palestine.

BMJ global health2026 Mar 02

This case study describes how high vaccination coverage was achieved during the 2024 polio vaccination campaign in Gaza amid an ongoing humanitarian crisis marked by damaged critical infrastructure, an obstruction of the entry of health supplies, mass displacement and security concerns for health workers. Despite the immense challenges, 559 161 children were vaccinated in the first round (94% of the revised target of 591 714) and 556 774 in the second round, exceeding expectations. While this represents an impressive achievement, some areas remained inaccessible, which prevented an estimated 7000-10 000 children from being reached for vaccination.Strong coordination and collaboration stewarded by the Gaza Ministry of Health with support from national and international partners.Negotiated humanitarian pauses in the form of 'days of tranquillity' agreed to by parties to the conflict enabling safe access for vaccinators, outreach teams and families.Prevaccination campaign sociobehavioural research to identify barriers and map information flows.Community engagement led by locally recruited volunteers embedded within affected communities, many of whom had themselves experienced displacement, supporting trust and acceptance.Culturally responsive communication strategies using multiple channels and feedback mechanisms.Adaptive vaccine management strategies and the development of a mobile cold chain.The campaign's success was underpinned by a multifaceted approach that included:Strong coordination and collaboration stewarded by the Gaza Ministry of Health with support from national and international partners.Negotiated humanitarian pauses in the form of 'days of tranquillity' agreed to by parties to the conflict enabling safe access for vaccinators, outreach teams and families.Prevaccination campaign sociobehavioural research to identify barriers and map information flows.Community engagement led by locally recruited volunteers embedded within affected communities, many of whom had themselves experienced displacement, supporting trust and acceptance.Culturally responsive communication strategies using multiple channels and feedback mechanisms.Adaptive vaccine management strategies and the development of a mobile cold chain.This case demonstrates that even in complex humanitarian crises, effective, community-centred vaccination strategies are possible. It also highlights how access and availability, not parental reluctance (or vaccine hesitancy), were the primary constraints on coverage. Parents showed strong willingness to vaccinate when services were accessible. Sustained advocacy and diplomacy remain essential to secure access, deliver equitable immunisation and create an enabling environment for humanitarian public health responses in conflict settings. However, the gains achieved through this campaign cannot meaningfully be sustained without a lasting ceasefire, the restoration of essential services and ongoing humanitarian access, particularly for infants born after the vaccination campaign who remain at heightened risk.

#3

Evaluation of hyper-attenuated S19 poliovirus strains for use in poliovirus neutralization assays.

PloS one2026

Poliovirus eradication efforts have relied on effective vaccination campaigns and stringent laboratory containment of poliovirus strains. Serological testing is the primary means to address population immunity, vaccine efficacy, and individual poliovirus exposures. However, strict containment requirements for Sabin type 2 and wild poliovirus types 2 & 3 limit access to serological testing. To address these limitations, we evaluated the performance of hyper-attenuated, temperature-sensitive S19 poliovirus strains (S19-PV), which retain the antigenic characteristics of Sabin and Salk strains but can be handled under biosafety level 2 (BSL-2) conditions. Using a modified microneutralization assay, we performed a comparative validation of S19-PVs to their Sabin and wild-type counterparts using WHO international standards, in-house control reagents, and human sera. Neutralizing antibody titers showed strong concordance between S19-PV and reference strains (R² = 0.93-0.99), with high intra- and inter-assay reproducibility (CVs < 10%). Our findings demonstrate that S19-PV strains are antigenically equivalent to Sabin and wild-type viruses and suitable for use in neutralization assays to determine levels of poliovirus neutralizing antibodies outside of strict containment laboratories. Adoption of these strains can significantly expand global capacity for poliovirus serological testing, supporting surveillance and immunization activities in the final stages of poliovirus eradication.

#4

Assessing Seroprevalence and Infection Dynamics of Oncogenic Gammaherpesviruses in South African Paediatric Patients Presenting with Inflammatory Conditions.

International journal of molecular sciences2026 Jan 27

Kaposi's Sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) are oncogenic gammaherpesviruses with high prevalence in sub-Saharan Africa. Both viruses are typically acquired during childhood, establishing lifelong latency. While viral reactivation into the lytic cycle has been mainly studied in adult HIV-infected populations-and more recently in the context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) co-infection-the dynamics of KSHV and EBV infection in children remain poorly understood. Here, we characterize pediatric patients (n = 175; median age 4.6 years; IQR 2.0-8.3) presenting with inflammatory conditions during the COVID-19 pandemic in South Africa (from July 2020 to February 2024). Including a healthy, non-inflammatory control group, we found widespread exposure to SARS-CoV-2 (70.9% seropositivity), with 72.6% of the children being seropositive for EBV and 19.4% for KSHV. There were no significant differences in seroprevalence between children with inflammatory conditions and healthy controls for any of these viruses, although SARS-CoV-2 antibody titers were significantly higher in the inflammatory group, while EBV immune responses were lower in children presenting with inflammation. Among the KSHV-seropositive children, no active viremia was detected (as determined by the absence of viral DNA in the peripheral blood). In contrast, 34.4% of EBV-seropositive children had detectable EBV viral load, with a modestly higher proportion in the inflammatory group. However, EBV viral load levels were comparable between children diagnosed with Multisystem Inflammatory Syndrome in Children (MIS-C), Kawasaki Disease (KD), and other inflammatory conditions. Logistic regression analyses revealed that increasing age was significantly associated with higher risk of SARS-CoV-2 and EBV seropositivity, but not KSHV. Notably, the risk of EBV DNA detection in the peripheral blood decreased with age. In summary, this study suggests effective immunological control of gammaherpesvirus infections in HIV-negative paediatric patients, even in the presence of inflammatory conditions that might otherwise trigger viral reactivation.

#5

Chronobiology of neurotropic viruses: rhythmic viral entry and arrhythmic host clocks.

Cell discovery2026 Feb 10

Neurotropic viruses invade neural tissues, resulting in severe diseases such as poliomyelitis, rabies, herpesviral encephalitis, and viral meningitis. Given this neurotropism, we investigated whether the infection of the host by these viruses is under circadian control. In this study, we found that the expression of most neurotropic virus receptors exhibits rhythmicity across cells, cerebral organoids, and animal models, with host cell susceptibility modulated by the circadian clock. We identified E2F8 as a clock-controlled gene that mediates the indirect regulation of the circadian clock on neurotropic viruses. Notably, E2F8 regulated the expression of core clock components by binding directly to the promoters of REV-ERBα and PER2, suggesting its role as a potential modulator of circadian rhythms. Additionally, we revealed a seldom-recognized viral strategy to accelerate viral replication in the host: rabies virus disrupts the host circadian clock system primarily through its glycoprotein hijacking the E3 ubiquitin ligase HUWE1 to inhibit proteasomal degradation of REV-ERBα. These findings increase our understanding of the interactions between circadian systems and neurotropic viral dynamics and highlight the potential of chronotherapy for improved antiviral treatments.

Publicações recentes

Evaluation of Coverage Rates of 3 Pediatric Vaccines (Measles-Mumps-Rubella, Hexavalent, and Varicella) in a Southern Italian Province (2016-2022): Effect of the Pandemic and Interregional Comparisons.

Med Sci Monit2026 Apr 10

Steindler flexorplasty in the management of elbow flexion deficits due to musculocutaneous nerve palsy: medium and long-term outcomes in two cases.

JSES Rev Rep Tech2026 May

Characteristics of Polish travellers admitted at the University Centre of Maritime and Tropical Medicine in Poland, 2024-2025.

Int Marit Health2026

Association of Plasma and Cerebrospinal Fluid Glucose Level with Clinical Severity in Patients with Guillain-Barre Syndrome.

Mymensingh Med J2026 Apr

Safety of Sabin-Strain Inactivated Poliovirus Vaccine Administered Alone or Concomitantly with Other Vaccines: A Population-Based Post-Marketing Surveillance Study.

Vaccines (Basel)2026 Mar 6

Ver todas no PubMed

📚 EuropePMC12.232 artigos no totalmostrando 198

Broad-acting antivirals: the pursuit of pan-viral therapeutics in the era of pandemics.

Journal of virology

Development and evaluation of an assay for the detection of tick-borne encephalitis virus RNA via real-time PCR with reverse transcription.

Parasites & vectors

New microbes and new infections

A review of the current anti-Cryptococcus antifungals and emerging treatment strategies.

Estimating population immunity against serotype-two poliomyelitis from the inactivated polio vaccine in routine immunization across 112 countries: A modelling study.

PLoS medicine

Application of a humeral intramedullary nail for subtrochanteric fracture in a patient with poliomyelitis sequelae: a case report.

Frontiers in surgery

The Journal of arthroplasty

Total Knee Arthroplasty in Post-Polio Residual Paralysis: A Systematic Review and Pooled Analysis of Its Outcomes and Complications.

Foot & ankle international

Modified Lambrinudi Combined With X-Shaped Plate Internal Fixation for Triple Arthrodesis.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Poliomyelitis, the years before vaccination. A reading through art.

Machine learning framework for early detection of polio outbreaks from acute flaccid paralysis surveillance data.

Virology

Leveraging community insights and navigating logistical challenges: a case study of the 2024 polio vaccination campaign in Gaza, State of Palestine.

Genetic Diversity and Excretion Kinetics of Enteroviruses Excreted by Patients with Primary Immunodeficiency in Tunisia over a Five-Year Period (2020-2024).

Evaluation of hyper-attenuated S19 poliovirus strains for use in poliovirus neutralization assays.

Case Report: Infant with vaccine-associated paralytic poliomyelitis unveils global disparities in care for inborn errors of immunity.

Scandinavian journal of immunology

Immunogenicity, Safety and Immune Persistence of Sabin Strain Inactivated Poliovirus Vaccine: A Phase III Clinical Trial.

Quality of life and associated factors in tunisian postpoliomyelitis syndrome patients.

La Tunisie medicale

Sleep & breathing = Schlaf & Atmung

Determining the presence of restless legs syndrome in patients with poliomyelitis sequelae and its effect on pain, fatigue, sleep and quality of life.

Digitising payments for campaign health workers in Africa: the promise and the path to sustainable scale.

[Late-onset sequel states of poliomyelitis (postpolyomelitic syndrome)].

Assessing Seroprevalence and Infection Dynamics of Oncogenic Gammaherpesviruses in South African Paediatric Patients Presenting with Inflammatory Conditions.

Cadernos de saude publica

[Temporal and spatial heterogeneities of childhood vaccination coverage in Brazilian state capitals: a methodological proposal using an applied and expected dose ratio].

Human vaccines & immunotherapeutics

Safety evaluation of inactivated poliomyelitis vaccine.

Chronobiology of neurotropic viruses: rhythmic viral entry and arrhythmic host clocks.

Cell discovery

Prediction of recent HIV-1 infections using Shannon entropy analysis of HIV-1 group-specific antigen protein sequence.

Preliminary safety evaluation of a diphtheria, tetanus, acellular component pertussis, Sabin inactivated poliovirus and Haemophilus influenzae type b combination vaccine (DTacP-sIPV/Hib).

Specific determination of influenza virus A by SERS-active spike-like track-etched membranes.

Analytica chimica acta

Preclinical Study on Sabin Strain-Based DTaP-sIPV/Hib Pentavalent Vaccine: Evaluation of Repeated-Dose Toxicity and Immunogenicity.

Novel Multistage Subunit Mycobacterium tuberculosis Nanoparticle Vaccine Confers Protection Against Experimental Infection in Prophylactic and Therapeutic Regimens.

Molecular Characterization of Avulaviruses Isolated from Mallard Ducks in Moscow in 2008-2024.

Veterinary sciences

PLOS global public health

The role of the media in the coverage of childhood vaccination in children under two years of age in Peru, ENDES 2021-2024.

Preventive medicine reports

Vaccine delay in routine childhood vaccines in the post-COVID-19 era in Jiangning, Nanjing, China.

Higher stability of novel live-attenuated oral poliovirus type 2 (nOPV2) despite the emergence of a neurovirulent double recombinant strain in Uganda.

Nature microbiology

Effectiveness of poliovirus environmental surveillance in Ghana: an indicator-based performance evaluation across seven regions, 2018-2022.

BMJ open

Open forum infectious diseases

Botulism Sequelae: A Systematic Review.

Post-pandemic assessment of parental perceptions toward COVID-19 vaccination and general immunization-an insight from polio endemic country.

Combination of vemurafenib, pleconaril, and AG7404 attenuates enterovirus replication in vitro and in vivo.

NAR molecular medicine

Mind the gap: A qualitative assessment of limitations in school-age immunisation programme delivery for Orthodox Jewish children in northeast London.

Journal of orthopaedic case reports

Tibialization of Fibula in an Implant Failure Non-Union Poliotic Limb: A Case Report.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Digital twin frameworks for polio and post-polio neurodegeneration: Toward predictive, personalised lifelong neuro-rehabilitation.

Tick-borne encephalitis virus variants drive distinct TCR repertoire alterations.

Double Trouble: Guillain-Barré Syndrome (GBS) Presenting as Overlapping Miller Fisher Syndrome (MFS) and Pharyngeal-Cervical-Brachial (PCB) Variant.

Indian journal of pediatrics

My Odyssey in Pediatrics & Neonatology : Based on 18th Dr. K. C. Chaudhuri and Dr. Amala Chaudhuri Oration, on 5th October 2025.

British journal of anaesthesia

Bjørn Ibsen: intensive care and the conundrum of prolonging death.

Surveillance of West Nile Virus in Tunisia: Evidence from Human and Entomological Investigation.

Pathogens (Basel, Switzerland)

Implementation of Poliovirus Containment in Poliovirus Designated Facilities-United States, 2017-2024.

Mono-WNV and combined WNV/TBEV inactivated vaccine efficacy against a wide range of WNV and TBEV strains.

Reconstruction With Peroneus Longus Allograft for Chronic Subtotal Patellar Tendon Lesion: Surgical Technique and Clinical Implications.

PLOS global public health

A century of weekly notifiable disease incidence data by province in Canada.

Communicable diseases intelligence (2018)

Australian National Enterovirus Reference Laboratory annual report, 2024.

MRI of Neurogenic Human Motor Units Following Poliomyelitis.

Muscle & nerve

Immunogenicity and non-inferiority evaluation of dose-sparing adjuvanted inactivated polio vaccine in Wistar rats.

Diagnostic microbiology and infectious disease

Insights on vaccine-derived poliovirus type 2 outbreaks and novel oral polio vaccine candidates.

Nature reviews. Neurology

The global threat of vaccine-preventable neurological diseases.

Annals of medicine and surgery (2012)

A critical overview of the recent resurgence of polio in Pakistan as a public health concern for millions of children.

Euglycemic Diabetic Ketoacidosis Associated with Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors: A Case Series and Clinical Reflections.

Factors associated with the circulation of vaccine-derived polioviruses in children under five in Kilwa, Haut-Katanga province, Democratic Republic of Congo, 2022-2023.

BMC infectious diseases

One health (Amsterdam, Netherlands)

Towards understanding a potential Cryptococcus neoformans environmental-host transmission route in agricultural settings.

Brain and nerve = Shinkei kenkyu no shinpo

[Duchenne de Boulogne: Pioneer of Neurology].

In vivo and in vitro Models of Hepatitis B Virus Infection.

Biochemistry. Biokhimiia

Zhongguo gu shang = China journal of orthopaedics and traumatology

[Short-to-medium-term clinical efficacy of total hip arthroplasty with Pinnacle ES constrained liner in the treatment of femoral neck fractures associated with lower limb neuromuscular disorders].

The p48 isoform of the PA2G4/EBP1/ITAF45 oncoprotein is required for the encephalomyocarditis virus IRES-driven translation initiation.

Nucleic acids research

The Journal of infectious diseases

Chlamydia trachomatis-specific T Cell Immunity Reflects Widespread Exposure in South African Adolescents and Young Women.

2024

[Current Status of Surveillance and Management for Maintaining Polio Eradication in the Republic of Korea].

Jugan geon-gang gwa jilbyeong

Characterization of a Sabin-like type 2/3 recombinant poliovirus with a triple nucleotide deletion in the VP1 region isolated from sewage.

Historical and current spatiotemporal patterns of wild and vaccine-derived poliovirus spread.

Nature microbiology

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Molecular evolution and circulation dynamic of human non-polio enteroviruses across Africa.

The Science of the total environment

Multiple African-origin circulating poliovirus-2 emergences identified in Israel: A reminder of an ongoing global challenge.

Atomic Force Microscopy of Poliovirus Particles After Inactivation by Chemical Methods and Accelerated Electrons.

Pharmaceuticals (Basel, Switzerland)

Longitudinal Cohort Event Monitoring of MMR and DT-IPV Vaccination at 9 Years of Age in The Netherlands.

Genetic Diversity of Selected High-Risk HPV Types Prevalent in Africa and Not Covered by Current Vaccines: A Pooled Sequence Data Analysis.

HSBDF-Derived Bioactive Components Broadly Inhibit Enteroviruses by Targeting 3C Protease and Attenuating Inflammatory Responses.

Biology

Journal of medical virology

Acute Flaccid Paralysis in a Vaccinated Child With Primary Immunodeficiency: Difficulties With Diagnostics of Vaccine-Associated Paralytic Poliomyelitis.

Journal of medical biography

The Production of Antibodies (1941) by F. M. Burnet or by Burnet, Freeman, Jackson and Lush: Collaboration in research.

Applied and environmental microbiology

Tracking poliovirus through wastewater: environmental surveillance insights from Haïti (2020-2023).

Media reporting trends on disease outbreaks of COVID-19, polio, and cholera in Nigeria: a scoping review.

BMC public health

Journal of health, population, and nutrition

A review on health system-based surveillance for acute flaccid paralysis: technological advancements, challenges, and outlooks.

Aging with disability in polio survivors: a narrative review.

Ewha medical journal

The global poliovirus eradication initiatives in Kano state, Nigeria: a case report on the African regional commission pre-certification visit and lessons learnt.

New approaches to measles eradication, with special reference to Africa.

Implant-based oral rehabilitation in patients with special needs: a case report.

AME case reports

Insufficient immune protection in preterm infants due to delayed or incomplete hexavalent vaccination.

The low genetic diversity of the Jingmen tick virus in Guinea sheds light on the recent introduction of the virus to West Africa.

Parasites & vectors

Intra-host diversity of SARS-CoV-2 in children with long-term and short-term excretion in nasopharyngeal samples.

BMC infectious diseases

Effectiveness of an Education Toolkit Delivered by Soap Operas Among Communities Living in Extreme Poverty in Improving Vaccination Confidence in the Philippines: Protocol for a Cluster Randomized Controlled Trial.

JMIR research protocols

Immunogenicity and safety of polio vaccines in infants: a systematic review of randomized clinical trials.

ARFGAP1 serves as a critical host factor during E30 infection: QS11 inhibits viral pathogenesis in hFcRn-IFNAR-/- mice.

Continuous Circulation of Hepatitis E and A Viruses During COVID-19 Pandemic Lockdowns in Munich, Germany-Experience from Three Years of Wastewater Surveillance.

Assessing the Anti-Cryptococcus Antifungal Potential of Artemisinin.

Impediments to Progress Toward Polio Eradication During 2014-2024: Effectively Addressing the Current Challenges.

Generation of Polyclonal Antibodies Against Sabin Poliovirus D- and H-Antigens and Their Application in ELISA.

Preclinical Immunogenicity Evaluation of a DTacP-sIPV/Hib Combination Vaccine in Rodent Models Under Varying Formulations and Immunization Schedules.

[Effect of inactivated whole-virion concentrated purified vaccine for the prevention of COVID-19 on clinical and biochemical blood parameters of immature rats].

Voprosy virusologii

[Detection of the Liman tick virus (unclassified Chuviridae) in tick cell line HAE/CTVM8].

Voprosy virusologii

Disability and rehabilitation

Reduction in energy cost of walking is associated with improved ankle plantarflexion moment during mid-stance following ankle-foot orthosis treatment in polio survivors with calf muscle weakness.

Antibody response to tetanus, diphtheria, poliomyelitis, hepatitis B, and H. influenzae b vaccines in allogeneic hematopoietic stem cell transplant adult recipients: A multicenter trial.

Optimizing preparedness and response for circulating vaccine derived poliovirus (cVDPV) outbreaks in the Eastern Mediterranean Region with a particular focus on cVDPV2.

The Diagnostic Difficulty of Acute, Disabling Neurology: Varicella-Zoster Virus Polyradiculopathy Presenting as Acute Flaccid Paraparesis in an Elderly Male Patient With a History of Poliomyelitis.

Genotype-dependent cell tropism of EV-A71 at the human blood cerebrospinal fluid and blood brain barrier.

Microbial pathogenesis

[Current situation of people with polio and post-polio syndrome in Spain].

Osteoporosis and sarcopenia

Vaccine hesitancy and bone health: Musculoskeletal sequelae of vaccine-preventable diseases.

Evaluation of the acute flaccid paralysis surveillance system performance in the Upper West Region of Ghana from 2021 to 2023: a retrospective descriptive study.

BMJ open

Self-reported poliomyelitis vaccination and documentation in adults indicates high uptake: a digital German epidemic panel, December 2024.

BMC public health

NanoDeNovo: De Novo Design of Anti-Poliovirus I Sabin Strain Nanobodies by Semi-Automated Computational Pipeline.

Estimating proportions of missed children and reasons for non-vaccination following implementation of "reaching the unreached" multiantigen immunization campaign-south Khyber Pakhtunkhwa, Pakistan, July-August 2023.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Recent emergence of vaccine-derived poliovirus type 2 in Senegal and virus spread to neighboring countries.

Structural Barriers and the Future of AI in Global Health: Lessons From Eradicable Diseases.

Clinical immunology (Orlando, Fla.)

Oral live attenuated polio vaccines induce enhanced T-cell responses with broad antigen recognition compared to inactivated polio vaccines.

The Journal of arthroplasty

Primary Total Knee Arthroplasty in Patients Who Have Neuromuscular Disorders and Genu Recurvatum Using a Rotating-Hinge Implant: A Case Series With a Mean 4-Year Follow-Up.

Distribution of Mukawa virus (Phlebovirus mukawaense) in Russia.

Current status of BCG and OPV vaccination in children with primary immunodeficiency in Chongqing, China.

Medicine

A novel approach to poliovirus vaccine neurovirulence testing: development of an enhanced 4-level scoring system.

Immunobiology

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

The decrease in childhood vaccination coverage and its sociodemographic determinants, the Netherlands, birth cohorts 2008 to 2020.

Australian and New Zealand journal of public health

Staying polio free: A capture-recapture analysis of acute flaccid paralysis surveillance in the Australian Capital Territory.

Immunization route-mediated differences in long-term maturation of humoral immune response induced by adenovirus vector-based COVID-19 vaccine Sputnik V in nonhuman primates.

Post-Polio Syndrome: Impact of Humoral Immune Deficiencies, Poliovirus Neutralizing Antibodies, Vitamin D Deficiency.

The Omicron Wave in Tunisia: Dynamic, Diversity, and Phylogenetic Analyses.

International orthopaedics

Orthopaedic portrayals in The Seven Works of Mercy painted by a Dutch master in the year 1504.

BMJ (Clinical research ed.)

Effect of BCG Danish and oral polio vaccine on neonatal mortality in newborn babies weighing less than 2000 g in India: multicentre open label randomised controlled trial (BLOW2).

Expert review of vaccines

The public health and economic impact of the Greek pediatric national immunization program.

Revista espanola de anestesiologia y reanimacion

Poliomyelitis: The paradigm of an eliminated disease: Sequelae and challenges to eradication.

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]

[Analysis of the immunization status and related factors for children aged 0-7 years old with special health status in Tianhe District, Guangzhou City from 2023 to 2024].

Assessment of environmental surveillance for the detection of poliovirus implementation in the metropolitan districts of South Africa, 2020-2023.

The effect of supporting districts to operationalise digital payments for vaccination campaign workers: a cluster randomised controlled trial during the 2022 polio vaccination campaign in Uganda.

Characterisation of a secreted MFSD6-Fc microbody as a decoy receptor for respiratory enterovirus D68.

EBioMedicine

Potential Causal Relationships Between Circulating Micronutrient Levels and Multiple Neuroimmune Diseases: A Genetic Association Analysis.

Brain and behavior

Transactions of the Royal Society of Tropical Medicine and Hygiene

Poliovirus surveillance in Mayotte, Indian Ocean, reveals encephalomyocarditis virus type 1 and a wide diversity of non-polio enteroviruses.

Low-grade persistent poliovirus infection in long-term polio survivors diagnosed with post-polio syndrome: diagnostic and clinical implications.

Journal of neurology

Poliomyelitis dynamics with fractional order derivatives and deep neural networks.

Scientific reports

Application of a comprehensive approach to pathogen screening in a stowaway rat on an airplane.

Scientific reports

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

Early detection of a circulating pre-vaccine-derived poliovirus type 1 (pre-VDPV1) variant linked to an acute flaccid polio case prior to VDPV1 emergence, Israel, 2024 to 2025.

Exploring the Contextual Factors That Influence Polio Supplementary Immunisation Activities in the WHO African Region: A Rapid Review.

Degradation of Poliovirus Sabin 2 Genome After Electron Beam Irradiation.

Unveiling a Shift in the Rotavirus Strains in Benin: Emergence of Reassortment Intergenogroup and Equine-like G3P[8] Strains in the Post-Vaccination Era.

Lipid Nanoparticle-Encapsulated TALEN-Encoding mRNA Inactivates Hepatitis B Virus Replication in Cultured Cells and Transgenic Mice.

American journal of public health

Political Polarization During Disease Outbreaks: A Meta-Analysis of Archival Survey Data From Polio to COVID-19.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre

Evidence of Subclinical Visual Pathway Dysfunction in Polio Survivors: A Visual Evoked Potential Study.

Plummer-Vinson syndrome in a postpolio patient: a rare intersection of neuromuscular and nutritional sequelae.

BMJ case reports

[Poliomyelitis vaccination: politics, problems and people. An unfinished story].

Breaking barriers: a qualitative study on polio vaccine hesitancy in Herat Province, Afghanistan.

BMC public health

The Lancet. Infectious diseases

Safety and immunogenicity of novel live attenuated type 1 and type 3 oral poliomyelitis vaccines in healthy adults in the USA: a first-in-human, observer-masked, multicentre, phase 1 randomised controlled trial.

The Science of the total environment

Lessons learned from upstream wastewater sampling in response to poliovirus in New York State.

Characteristics of four natural poliovirus type 1 variants with six-nucleotide deletion (2,783-2,788 nt) in the VP1 region.

Microbiology spectrum

Bulletin of the World Health Organization

Collateral damage from violent incidents: human costs of polio immunization.

Variation in HIV-1 Tat and Vpr protein amino acid sequences and its association with vascular health measures in a South African cohort: an exploratory study.

Journal of preventive medicine and hygiene

The summer colonies: 'custodians' of the health of the young. Prophylaxis of infectious diseases and educational purposes in the reports of the school medical inspector Benedetto Barni (1893-1970) in the 1950s.

Medical journal of the Islamic Republic of Iran

Dual Mobility Acetabular Cup Utilization in Total Hip Arthroplasty: Mitigating Instability Risks.

Advances and challenges in poliomyelitis vaccines: a comprehensive review of development, production, and global deployment.

Immunogenicity of DNA, mRNA and Subunit Vaccines Against Beak and Feather Disease Virus.

Assessment of Oral Poliovirus Vaccine Viability and Titer at Delivery Points in Kinshasa, the Democratic Republic of the Congo: Implications for Cold Chain Management.

Immune and Safety Analysis of ultraIPVTM, a Novel UVC-Inactivated Polio Vaccine.

The Journal of infectious diseases

Clinical and Environmental Surveillance of Poliovirus Type 2 Outbreak Using a Novel Specific Real-time Quantitative Polymerase Chain Reaction Assay, Israel, 2022-2023.

International medical case reports journal

Acute Transverse Myelitis in a Child Following Oral Live Polio Vaccine Administration.

Updates on the polio surveillance action plan's key performance indicators: East and Southern African countries (January 2022 to December 2023).

Evaluation of acute flaccid paralysis surveillance system in Kebbi State, Nigeria between 2013-2018.

Journal of medical virology

Global Evolution and Transmission Dynamics of Enterovirus D68.

Polio vaccination campaigns in conflicts: succeeding while other humanitarian efforts fail?

A qualitative study on gender relations and digital payments: healthcare workers' experiences during polio vaccination campaigns in Uganda and Malawi.

Assessing early detection ability through spatial arrangements in environmental surveillance for poliovirus: A simulation-based study.

BMC musculoskeletal disorders

Surgical treatment of femoral medial condyle impaction fracture complicated with Hoffa fragment by contralateral medial distal tibia plate: a case report.

Immunogenicity and safety of sequential Sabin strain inactivated poliovirus vaccine from different manufacturers in infants: Randomized, blinded, controlled trial.

IGF-1 regulates LARP6-mediated collagen metabolism in vaginal fibroblasts of POP patients via the PI3K/AKT pathway.

Scientific reports

Pathological characteristics of a murine oral coxsackievirus A10 infection model.

Journal of virology

Genetic characterization of type 3 vaccine-derived poliovirus from a patient with hand, foot, and mouth disease in China.

Supplementary Surveillance of Poliovirus Circulation in the Russian Federation: Results of a Study on Migrant Children of "Risk Group".

Porcine Teschovirus 2 3Cpro Evades Host Antiviral Innate Immunity by Inhibiting the IFN-β Signaling Pathway.

SAGE open medical case reports

West Nile neuroinvasive disease with poliomyelitis syndrome: A grave phenomenon.

Reconstruction of a Chronic Quadriceps Tendon Rupture in an Elderly Polio Patient.

Biomedicines

Effects of workforce volatility, determinants of infant deaths and resilience in SUS Primary Care.

Ciencia & saude coletiva

Frontiers in endocrinology

Bone biomarkers in post-polio clinic patients.

Synthesis and antifungal properties of the new semiselenoglycolurils.

Molecular diversity

Open Lip Schizencephaly Misdiagnosed as Paralytic Poliomyelitis in an 85-Year-Old: A Case Report.

Clinical case reports

Preparedness and response to the international poliovirus and diphtheria reintroduction alert: public health interventions and strategy review in the Veneto Region, Italy.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

Prevalence of hepatitis B virus infection among pregnant women and cord blood hepatitis B surface antigen positive newborns in sub-Saharan Africa and South Asia.

[MEDICAL REHABILITATION DURING WAR: THE HISTORICAL PERSPECTIVE].

Harefuah

Creating cohesive communities: using Conditional-Collective-Community-Based Incentives to change social norms on polio immunization in Pakistan.

Determinants of incomplete immunization and factors for missed opportunities in urban Dhaka: A cross-sectional study.

[Poliomyelitis in Spain: from the past to the present, a continuous challenge].

The Lancet. Infectious diseases

Safety and immunogenicity of a reduced-dose inactivated poliovirus vaccine versus a full-dose inactivated poliovirus vaccine in infants in Bangladesh: a double-blind, non-inferiority, randomised, controlled, phase 3 trial.

Current opinion in neurology

Emerging neuroinfectious diseases: public health implications.

T-cell responses induced by SARS-CoV-2 index-virus nanoparticle protein vaccine to the ancestral and omicron variants 6 months following primary vaccination.

Communications medicine

Expert review of vaccines

Vaccination policies for dentists and other dental professionals in Europe: a systematic report.

Evolution and transmission dynamics of wild poliovirus in Pakistan and Afghanistan (2012-2023).

Nature communications

Journal of the Royal Society, Interface

Estimating epidemic dynamics with genomic and time series data.

The Journal of clinical investigation

Immune cells promote paralytic disease in mice infected with enterovirus D68.

varVAMP: degenerate primer design for tiled full genome sequencing and qPCR.

Nature communications

The Tryptophan-Kynurenine pathway in people living with HIV: a systematic review.

Infection

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

Acute flaccid myelitis in Europe between 2016 and 2023: indicating the need for better registration.

Understanding barriers to stool adequacy: results from a programmatic assessment of Pakistan's acute flaccid paralysis active surveillance system in 12 priority districts.

The Lancet. Global health

Safety of nOPV2 administered during a supplementary immunisation activity in Uganda, 2022: data triangulation from a prospective cohort event monitoring programme and vaccine safety surveillance reports.

Journal of health, population, and nutrition

Investigation and response to a type 3 vaccine-derived poliovirus detected in an infant with hand, foot, and mouth disease - Guangdong, China, 2023.

Deutsches Arzteblatt international

Achievements and Obstacles in the Late Phase of the Global Polio Eradication Initiative.

Infectious diseases (London, England)

The association of oral polio vaccine doses and severity of paralysis: an analysis of wild poliovirus type 1 cases in Pakistan.

[The role of international research stays and the European context of polio control in Spain].

Interrelationship between the Non-Vesicular Transport of Sterols and Their Distribution between the Rafts and the Non-Raft Phase of the Plasma Membrane.

Biochemistry. Biokhimiia

Revista panamericana de salud publica = Pan American journal of public health

[Technical cooperation strategies to revitalize immunization programs in priority countries in the AmericasEstratégias de cooperação técnica para revitalização do programa de imunização em países prioritários da Região das Américas].

Chinese clinical oncology

Anterolateral thigh flap harvested from paralyzed limbs in post-polio syndrome for tongue reconstruction-a case report and a review of the literature.

Pathogens (Basel, Switzerland)

Genotype I Newcastle Disease Virus, Isolated from Wild Duck, Can Protect Chickens Against Newcastle Disease Caused by Genotype VII.

Polio vaccination and marginal effects among children aged 12-23 months in Lesotho using 2024 LDHS data: A multilevel analysis approach.

Ver todos os 12.232 no EuropePMC

Intestinal mucosal immune responses induced by novel oral poliovirus vaccine type 2 and Sabin monovalent oral poliovirus vaccine type 2: an analysis of data from four clinical trials.

The Lancet. Microbe

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