Raras
Buscar doenças, sintomas, genes...
Sepse de apresentação tardia em lactentes prematuros
ORPHA:90051CID-10 · P36.0CID-11 · KA60DOENÇA RARA

Doença sistémica rara que afeta recém-nascidos com menos de 37 semanas de idade gestacional e caracterizada por disfunção orgânica com risco de vida causada por uma resposta desregulada do hospedeiro a uma infeção, que pode ter sido adquirida pouco antes ou durante o nascimento (resultando em sepsis neonatal de início precoce durante as primeiras 72 horas de vida) ou após o nascimento (resultando em sepsis neonatal tardia entre 72 horas e três meses). A prematuridade constitui um dos principais fatores de risco para sepsis neonatal. O quadro clínico pode evoluir gradualmente com irritabilidade, letargia ou má alimentação, ou progredir rapidamente para desconforto respiratório, febre, hipotermia, hipotensão, choque e falência de multiorgânica.

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Introdução

O que você precisa saber de cara

📋

Doença sistêmica rara que afeta recém-nascidos com menos de 37 semanas de idade gestacional e disfunção orgânica com risco de vida causada por uma resposta desregulada do hospedeiro a uma infecção, que pode ter sido adquirida pouco antes ou durante o nascimento (resultando em sepse neonatal precoce durante as primeiras 72 horas de vida) ou após o nascimento (resultando em sepse neonatal tardia entre 72 horas e três meses). A prematuridade constitui um dos principais fatores de risco para sepse neonatal. O quadro clínico pode evoluir com irritabilidade, letargia gradualmente ou mais alimentação, ou progredir rapidamente para desconfortos, febre, hipotermia, hipotensão, choque e falência multiorgânica.

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
1-5 / 10 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
32.0
Europe
Início
Neonatal
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: P36.0
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🫃
Digestivo
8 sintomas
🩸
Sangue
7 sintomas
🛡️
Imunológico
4 sintomas
❤️
Coração
3 sintomas
🫁
Pulmão
2 sintomas
🧠
Neurológico
2 sintomas

+ 21 sintomas em outras categorias

Características mais comuns

90%prev.
Taquicardia
Muito frequente (99-80%)
90%prev.
Anormalidade da fisiologia do sistema imunológico
Muito frequente (99-80%)
90%prev.
Nascimento prematuro
Muito frequente (99-80%)
90%prev.
Sepse neonatal
Muito frequente (99-80%)
90%prev.
Pequeno para a idade gestacional
Muito frequente (99-80%)
55%prev.
Dismotilidade gastrointestinal
Frequente (79-30%)
51sintomas
Muito frequente (5)
Frequente (17)
Ocasional (26)
Muito raro (3)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 51 características clínicas mais associadas, ordenadas por frequência.

TaquicardiaTachycardia
Muito frequente (99-80%)90%
Anormalidade da fisiologia do sistema imunológicoAbnormality of immune system physiology
Muito frequente (99-80%)90%
Nascimento prematuroPremature birth
Muito frequente (99-80%)90%
Sepse neonatalNeonatal sepsis
Muito frequente (99-80%)90%
Pequeno para a idade gestacionalSmall for gestational age
Muito frequente (99-80%)90%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1
Últimos 10 anos200publicações
Pico2025152 papers
Linha do tempo
2025Hoje · 2026🧪 1988Primeiro ensaio clínico
Publicações por ano (últimos 10 anos)

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Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
·Pré-clínico1
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 1 ensaio
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Sepse de apresentação tardia em lactentes prematuros

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

1 ensaios clínicos encontrados.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
0 papers (10 anos)
#1

Can topical coconut oil reduce late-onset sepsis in extremely preterm infants? A pragmatic cluster-randomised controlled trial protocol.

BMJ open2026 Mar 04

Infants born before 28 weeks' gestation account for approximately 75% of neonatal morbidity and mortality. Late-onset sepsis (LOS) affects around 25% of these infants and is associated with an increased risk of adverse long-term outcomes. The topical application of coconut oil has been used for centuries in newborn care. Coconut oil is rich in saturated fatty acids, several of which have demonstrated antimicrobial properties. It is considered safe for extremely preterm infants, improves skin condition and may reduce the incidence of LOS. This is a pragmatic, cluster-randomised, two-arm, parallel-group, multicentre, phase III clinical trial evaluating the effect of topical coconut oil versus routine skin care on the incidence of LOS in extremely preterm infants. Participating neonatal units will be cluster-randomised, and all infants born at <28 weeks gestational age will receive either routine skin care or routine care with the addition of topical coconut oil. A minimum of 616 infants will be recruited into each treatment arm. Intention-to-treat and per-protocol analyses will be performed. Following ethical approval, patients will be recruited at participating sites under a waiver of consent with opt-out framework. The trial results will be disseminated through conferences, media sources and publication in relevant peer-reviewed journals. ACTRN12620001332910.

#2

Drying Very Preterm Infants Before Plastic Wrapping at Birth: A Randomized Clinical Trial.

JAMA network open2026 Mar 02

Despite continuous improvements in neonatal resuscitation and stabilization in the last decades, thermal management immediately after birth remains an unresolved issue in preterm infants. To compare 2 strategies of thermal management (plastic wrapping with or without drying) for preventing heat loss at birth in very preterm infants. This multicenter, unblinded, randomized clinical trial was conducted among very preterm infants (birth weight <1500 g and/or gestational age ≤30 weeks 6 days) at 21 tertiary care hospitals in Italy from February 21, 2023, to July 18, 2024. Eligible neonates were randomly allocated to either drying before plastic wrapping in the delivery room (intervention arm) or plastic wrapping without drying (control arm). The primary outcome was the proportion of participants with normothermia (36.5-37.5 °C) at admission to the neonatal intensive care unit (NICU). The secondary outcomes included hypothermia (<36.5 °C), moderate to severe hypothermia (<36.0 °C), and hyperthermia (>37.5 °C) at NICU admission, temperature at 1 hour after NICU admission, intraventricular hemorrhage, respiratory distress syndrome, late-onset sepsis, bronchopulmonary dysplasia, and mortality before hospital discharge. Overall, 354 very preterm infants were randomized (180 [50.8%] female; mean [SD] gestational age, 28.6 [2.5] weeks); all received the allocated intervention and were included in the analysis. Normothermia at NICU admission was achieved in 81 of 177 dried infants (45.8%) and 82 of 177 undried infants (46.3%; risk ratio, 0.99; 95% CI, 0.79-1.24). The mean (SD) neonatal temperature at NICU admission was 36.4 °C (0.8 °C) in dried neonates and 36.5 °C (0.7 °C) in undried neonates (mean difference, -0.1 °C; 95% CI, -0.2 °C to 0.1 °C). In-hospital mortality included 26 of 177 dried neonates (14.7%) and 10 of 177 undried neonates (5.6%) (unadjusted risk ratio, 2.60; 95% CI, 1.29-5.23). The other secondary outcome measures were not different between the 2 arms. In this multicenter randomized clinical trial, drying before plastic wrapping provided no benefit to very preterm infants in maintaining normothermia at NICU admission. Most deaths could be expected due to the compromised profile of the neonates, with no pathophysiological explanation related to the trial interventions. Approximately half of the infants were outside the normal thermal range at NICU admission; hence, thermal management remains a challenge requiring further investigations. ClinicalTrials.gov Identifier: NCT05740072.

#3

Hospital-Acquired Citrobacter Meningitis Complicated by Pneumocephalus in a Neonate.

Pediatrics2026 Mar 01

Citrobacter koseri, a facultative gram-negative bacillus, colonizes the intestine and environmental reservoirs. In neonates, especially preterm infants, it can cause severe central nervous system infections (eg, meningitis, encephalitis, abscesses), often with fatal outcomes. Pneumocephalus, an accumulation of intracranial gas, is a rare but deadly complication. We report a preterm female infant admitted to the neonatal intensive care unit (NICU) for respiratory distress who developed high fever and sepsis; blood culture results were positive for C. koseri. Rapid neurological deterioration with seizures occurred, and a cranial computed tomography scan showed extensive pneumocephalus. Despite intensive care, the infant died at 17 days. Autopsy and histology revealed widespread purulent meningitis and meningoencephalitis, pneumocephalus, cerebral hemorrhages, acute edema, and ventricular dilation. An environmental investigation traced the origin of the infection to the bathroom sinks, confirming the nosocomial nature of the pathogen. This case highlights the high virulence of C. koseri in neonates, the catastrophic potential of pneumocephalus, and the crucial importance of strict infection control in NICUs.

#4

Immune profiles and growth outcomes in very and extremely preterm infants with bronchopulmonary dysplasia: A prospective cohort study.

Pediatrics and neonatology2026 Jan 21

Preterm birth is associated with immune dysregulation, and bronchopulmonary dysplasia (BPD) is the most prevalent complication affecting preterm infants. However, studies addressing the correlation between immune profiles and BPD severity in preterm infants remain limited. A total of 78 preterm infants born at less than 32 weeks of gestation and 46 full-term controls were enrolled. Basic characteristics, including birth data, medical history, and growth, and immune profiles including CD3+ T cells and subsets of CD4+ and CD8+ T cells, along with CD19+ B cells, were analyzed and compared across various gestational age (GA) and BPD grading groups. Extremely preterm infants and those with severe BPD had lower birth weights, lower body weight percentiles, and higher rates of sepsis at 6 months corrected age compared with full-term infants and those with no or mild BPD (P < 0.01). Among preterm infants, extremely preterm infants exhibited higher CD8+ T cell percentages with lower CD4/CD8 ratios than very preterm infants (P < 0.05). Infants with severe BPD had the highest percentage of CD4/CD8 ratios below the 25th percentile among BPD grading groups (P < 0.05). Furthermore, males had lower CD4+ T cell percentages than females (P < 0.05), but no differences in immune profiles were found between those with or without sepsis. Extremely preterm infants with severe BPD showed underdeveloped growth, higher sepsis rates, and altered high CD8+ T cells with lower CD4/CD8 ratios, which is potentially related to premature pulmonary processes in early infancy.

#5

S100-alarmins, antenatal corticosteroids and the risk of late-onset sepsis in preterm infants: A prospective cohort study.

PloS one2026

Antenatal corticosteroids (aCS) are an important measure improving the outcome of preterm infants. Their influence on late-onset sepsis (LOS) risk remains inconclusive. The alarmin S100A8/A9 protects from LOS by regulating innate immune responses. We examined whether aCS impact on postnatal S100A8/A9 serum-levels and consequently on LOS risk. In a prospective birth-cohort study of 162 preterm infants born before 32 gestational weeks, we determined postnatal S100A8/A9 serum-levels in relation to the timing of aCS and LOS incidence. aCS administration within 7 days before birth decreased LOS incidence in infants born via primary C-section compared to infants not exposed to aCS (5/69 (7.2%) vs. 4/27 (14.8%)). This effect was linked to increased S100A8/A9 levels, with nocturnal aCS administration being most effective. Opposite, S100A8/A9 levels were lower and the LOS incidence higher compared to unexposed infants (7/23 (30.4%) vs. 4/27 (14.8%)) when aCS were administered more than 14 days before delivery. Our data suggest that aCS administration affects the risk of LOS in preterm infants in dependence of the timing of administration by influencing the infant's S100A8/A9 levels. This underlines the importance of optimal timing of aCS facing imminent preterm birth.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC41 artigos no totalmostrando 200

2026

Two years Bacillus cereus outbreaks: investigations and effective management of contamination in a neonatal intensive care unit.

Antimicrobial resistance and infection control
2026

Evaluation of Patients With Pulmonary Hemorrhage in a Tertiary Neonatal Intensive Care Unit in Türkiye.

Pediatric pulmonology
2026

Epidemiological Profile of Neonates Admitted to a Neonatal Intensive Care Unit in Tertiary Care Referral Center of Nepal: A Four Years Cross Sectional Study.

Journal of Nepal Health Research Council
2026

Short Antibiotic Treatment for Coagulase-negative Staphylococcal Sepsis in Premature Infants: A Multicenter Noninferiority Study.

The Pediatric infectious disease journal
2026

Use of Aflibercept to Treat Retinopathy of Prematurity in Children with Extremely Low Birth Weight.

Journal of clinical medicine
2026

Jejunal web as the cause of bowel obstruction in an infant: case report and brief literature review.

International journal of surgery case reports
2025

Maternal and Neonatal Outcome of Surviving Twin after Single Fetal Demise at 17 Weeks: A Case Report.

JNMA; journal of the Nepal Medical Association
2026

Can topical coconut oil reduce late-onset sepsis in extremely preterm infants? A pragmatic cluster-randomised controlled trial protocol.

BMJ open
2026

Drying Very Preterm Infants Before Plastic Wrapping at Birth: A Randomized Clinical Trial.

JAMA network open
2026

Methicillin Resistant Staphylococcus Aureus Colonization, The Tip of the Iceberg for Congenital Pulmonary Airway Malformation. A Case Report.

La Clinica terapeutica
2026

Lungs in Crisis: Exploring the Complexity and Management of Pulmonary Hemorrhage in Premature Neonates.

Neonatal network : NN
2026

Hospital-Acquired Citrobacter Meningitis Complicated by Pneumocephalus in a Neonate.

Pediatrics
2026

Management of the newborn at risk for vertical sepsis.

Anales de pediatria
2025

Case Report: Clinical characteristics and multidisciplinary collaborative management of congenital tuberculosis in extremely preterm twins and preterm infants: a report of three cases and literature review.

Frontiers in pediatrics
2026

Risk factors and clinical features of feeding intolerance in preterm infants and the effect of multimodal oral-sucking-oromotor training: a single-center retrospective analysis.

The journal of maternal-fetal &amp; neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2026

Attributable Mortality of Late-Onset Sepsis in the Neonatal ICU According to Gestational Age: A Historical Propensity Score Matched Cohort Study.

Nursing in critical care
2026

Immune profiles and growth outcomes in very and extremely preterm infants with bronchopulmonary dysplasia: A prospective cohort study.

Pediatrics and neonatology
2025

Risk factors for hemodynamically significant patent ductus arteriosus and ibuprofen treatment failure in premature twins: a retrospective case-control study.

Frontiers in cardiovascular medicine
2026

S100-alarmins, antenatal corticosteroids and the risk of late-onset sepsis in preterm infants: A prospective cohort study.

PloS one
2026

[The Amniotic Fluid Index Does Not Predict Adverse Pregnancy Outcomes among Women with Rupture of Membranes at Term].

Harefuah
2026

Pregnancy outcomes in women at high risk of preterm birth receiving a vaginal cervical cerclage with, or without, progesterone: A retrospective, secondary analysis of the C-STICH randomised controlled trial data.

PLoS medicine
2026

Antimicrobial Resistance and Infant Mortality in Sri Lanka: A Retrospective Cohort Study.

Journal of paediatrics and child health
2026

Group B Streptococcus Sepsis with Cardiac Abscesses in a Neonate with Migrated Umbilical Catheter: Literature Review.

AJP reports
2026

Stratified Comparison of Risk Factors for Mild Versus Moderate-to-Severe Bronchopulmonary Dysplasia in Very Preterm Infants (< 32 Weeks Gestational Age).

Lung
2026

Primary pulmonary hypoplasia masquerading as pneumonia in a preterm neonate and creating a diagnostic challenge: a case report.

Journal of medical case reports
2025

Prediction of mortality by nSOFA Score for late-onset sepsis in very low birth weight infants.

Journal of infection in developing countries
2026

Clinical characteristics of invasive candidiasis in infants born before 30 weeks of gestation: a nested case series from a multicenter cohort study in the Netherlands and Belgium.

European journal of pediatrics
2026

Quality improvement interventions to prevent late-onset sepsis in premature infants: a systematic review and meta-analysis.

PeerJ
2026

Sepsis Associated Necrotizing Enterocolitis (SA-NEC) in Preterm Infants: Risk Factors and Clinical Outcomes.

Indian journal of pediatrics
2026

Cluster-randomized evaluation of neonatal intensive care unit quality improvement interventions in extremely preterm infants: secondary analysis of the INTACT trial.

BMC pediatrics
2026

Salmonella meningitis due to horizontal transmission in an extremely premature neonate: A case report.

Journal of neonatal-perinatal medicine
2026

Effectiveness and feasibility of orogastric tube for surfactant delivery in moderate or very preterm neonates with respiratory distress syndrome: an open-label randomized controlled trial.

Journal of tropical pediatrics
2025

Comparison of the effect of surfactant with and without budesonide on the outcomes of respiratory distress syndrome (RDS) in premature infants: a randomized control trial.

BMC pregnancy and childbirth
2026

Effect of Oral Colostrum Administration Duration on Clinical Outcomes in Preterm Infants: A Randomized Controlled Trial.

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine
2026

A physiologic Comparison of Continuous Neurally Adjusted Ventilation (NeuroPAP) Versus Neurally-Adjusted Ventilatory Assist (NAVA) in Infants With Respiratory Failure.

Pediatric pulmonology
2025

Duodenojejunostomy versus Duodenoduodenostomy in Congenital Duodenal Obstruction: A retrospective study.

The Medical journal of Malaysia
2025

Breast Milk-acquired Cytomegalovirus Infection in Premature or Very Low Birth Weight Infants: A Systematic Review.

The Pediatric infectious disease journal
2025

Purpura Fulminans and Group B Streptococcal Sepsis in an Extremely Low Birth Weight Premature Infant.

Case reports in infectious diseases
2026

Outcomes in extremely preterm neonates after the introduction of early low-dose hydrocortisone treatment: A retrospective case-control study.

Early human development
2025

Golden hour(s) quality improvement protocols and their effect on outcomes in preterm infants ≤ 32 weeks of gestation: a scoping review.

BMC pediatrics
2025

Listeria monocytogenes bacteremia in an AIDS patient during pregnancy: A case report.

Medicine
2025

HELLP syndrome as a major contributor to adverse maternal and neonatal outcomes among preeclamptic women: findings from a multicenter retrospective cohort study.

BMC pregnancy and childbirth
2026

Acute kidney injury in extremely preterm infants: findings from an Australian single-centre retrospective cohort study.

Pediatric nephrology (Berlin, Germany)
2025

Clinical, laboratory, and microbiological differences between early- and late-onset neonatal sepsis in preterm infants: a cross-sectional study in Vietnam.

BMC pediatrics
2025

Impact of bronchopulmonary dysplasia, brain injury, necrotizing enterocolitis, retinopathy of prematurity and sepsis on neurodevelopmental outcomes in premature infants.

Journal of perinatology : official journal of the California Perinatal Association
2025

Development and validation of a pre-trained language model for neonatal morbidities: a retrospective, multicentre, prognostic study.

The Lancet. Digital health
2025

Neonatal outcomes associated with maternal arbovirus infection (dengue, Zika, and chikungunya) among pregnant women with obstetric complications in Brazil: a cross-sectional study.

Revista da Sociedade Brasileira de Medicina Tropical
2025

Novel association between true surgical pneumoperitoneum secondary to bowel perforations in a newborn and congenital diaphragmatic hernia.

BMJ case reports
2026

Deferred Cord Clamping in Very Preterm Triplets and Outcomes: A Retrospective Cohort Study.

Neonatology
2025

Neonatal fungemia: a case series highlighting the threat posed by non-albicans Candida (NAC) species and a yeast-like filamentous fungus.

BMC infectious diseases
2026

[Consistency and risk factor analysis of 2 growth chart in the diagnosis of extrauterine growth restriction in preterm infants with a gestational age at birth of less than 32 weeks].

Zhonghua er ke za zhi = Chinese journal of pediatrics
2025

Variations in length of stay among surviving preterm infants admitted to neonatal intensive care units in Shenzhen, China.

PeerJ
2025

Characterising commensal and pathogenic staphylococcal interactions with neonatal and adult blood.

Scientific reports
2025

Outcomes and antimicrobial usage in preterm neonates < 34 weeks gestation with culture-negative neonatal sepsis: a prospective observational study.

BMC infectious diseases
2026

Herbal galactagogues to improve breastmilk production and lactation in mothers of preterm babies: a systematic review of clinical trials.

European journal of clinical nutrition
2025

Where to invest in neonatal survival programs in Nepal? A modelling study using Lives Saved Tool through scaling key interventions.

PloS one
2025

Spatio-Temporal Fuzzy Coding of Video Motion Time Series for Late Onset Sepsis Detection in Neonatalogy.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
2025

Genetic disorders and associated morbidity, mortality, and congenital anomalies in preterm infants born at less than 34 weeks of gestation.

BMC pediatrics
2025

Staphylococcus aureus colonization and bloodstream infection in very preterm infants.

Gut microbes
2025

Hematocrit in the first 2 hours of life and short-term outcomes in very preterm infants: A secondary analysis from a prospective cohort study.

PloS one
2025

Breast milk-acquired cytomegalovirus (aCMV) infection with sepsis-like syndrome in extremely preterm twins.

IDCases
2025

MicroRNA Profiling as a Novel Tool in the Diagnostics of Late-Onset Neonatal Sepsis: A Scoping Review.

Children (Basel, Switzerland)
2025

Analysis of risk factors and establishment of a predictive model for brain injury in neonates with surgical necrotizing enterocolitis: a retrospective study.

BMC pediatrics
2026

Early phosphate supplementation reduces refeeding syndrome and improves clinical outcomes in very-preterm infants: A retrospective cohort study.

Clinical nutrition ESPEN
2025

Volumetric analysis of term-equivalent age MRI in post-haemorrhagic ventricular dilatation reveals association between deep grey matter volume and developmental outcomes.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2025

Outcome of infants with bronchopulmonary dysplasia.

PloS one
2025

Do we need to reconsider our antibiotic regimen for preterm premature rupture of membranes? Pathogens and perinatal outcome in PPROM.

BMC pregnancy and childbirth
2025

Prevalence and risk factors of neonatal sepsis in the neonatal intensive care unit at Soroti Regional Referral hospital, Uganda: a retrospective study.

BMC pregnancy and childbirth
2026

Premature rupture of the membranes in twin pregnancies: Maternal and fetal outcomes.

Journal of gynecology obstetrics and human reproduction
2025

Development and validation of a nomogram for predicting necrotizing enterocolitis in premature infants with early-onset sepsis.

Scientific reports
2026

Antenatal corticosteroid administration in periviable twin pregnancies between 22 and 25 weeks: a nationwide-based study.

American journal of obstetrics and gynecology
2025

Dopamine versus norepinephrine in fluid-refractory septic shock among preterm neonates: a double-blind randomized controlled trial.

Journal of tropical pediatrics
2025

Time to Full Enteral Feeds and Late-Onset Sepsis in Extremely Preterm Infants.

JAMA network open
2026

Immediate kangaroo mother care: a narrative review of the benefits and barriers.

World journal of pediatrics : WJP
2025

De novo CHD7 variant in a CHARGE syndrome preterm infant initially diagnosed as idiopathic hypogonadotropic hypogonadism: a case report and literature review.

BMC pediatrics
2025

Neonatal Brucellosis in an Extremely Preterm Infant: A Fatal Case Report.

Case reports in infectious diseases
2025

Association between middle cerebral artery doppler flow parameters and intraventricular hemorrhage in preterm infants.

Neuro endocrinology letters
2025

The delivery modes and morbidity/mortality in very preterm infants with birth weight <1,500 g: a retrospective cohort study.

Frontiers in public health
2025

Sensory processing and motor development in term infants following late-onset neonatal sepsis-a cross-sectional study.

European journal of pediatrics
2025

Association between group B beta-hemolytic Streptococcus screening during pregnancy and the prevalence of early-onset neonatal sepsis.

Revista da Associacao Medica Brasileira (1992)
2025

Risk Factors for Histologic Chorioamnionitis Among Women with Prenatal Fever During Preterm Delivery: A Retrospective Cohort Study.

International journal of women's health
2025

Identifying the anti-infection NK and T cell subgroups in preterm newborns with sepsis using single-cell RNA-seq analysis.

European journal of medical research
2025

Integrated placental and neonatal urinary detection of Ureaplasma urealyticum: A translational approach to predicting adverse neonatal outcomes.

Placenta
2026

Intestinal fatty acid binding protein (I-FABP) as a sensitive and specific biomarker for necrotizing enterocolitis (NEC) in pre-term infants.

Journal of pediatric surgery
2025

Effectiveness of Antenatal Corticosteroids in reducing morbidities and mortality in Preterm neonates: Evidence from a Tertiary Level Hospital in Nepal.

PloS one
2025

Seizures in Infants With Congenital Heart Disease: A National Cohort Study.

Journal of the American Heart Association
2025

Association between serum phosphate levels and length of hospital stay in infants with neonatal sepsis: a retrospective cohort study.

BMC pediatrics
2025

Clinical association and potential molecular mechanisms of neonatal sepsis and necrotizing enterocolitis.

Frontiers in molecular biosciences
2025

Adverse pregnancy outcomes and complications of tuberculosis in pregnant women.

Frontiers in cellular and infection microbiology
2025

Dynamic Interactions between the Gut Microbiome, Health, and Metabolic Disorders in Preterm Infants.

Journal of microbiology and biotechnology
2025

Preventing Sepsis in Preterm Infants with Bovine Lactoferrin: A Randomized Trial Exploring Immune and Antioxidant Effects.

Nutrients
2025

Risk factors for bronchopulmonary dysplasia in preterm infants: a systematic review and meta-analysis.

PeerJ
2025

Improved Outcomes of Very Low Birth Weight Infants in Korea: 2015-2016 vs. 2021-2022 From the Korean Neonatal Network.

Journal of Korean medical science
2025

Quality improvement initiative to reduce late-onset sepsis in very low birth weight preterm infants: a multicenter study from the Brazilian network on neonatal research.

Jornal de pediatria
2025

[Intrauterine Inflammation and Short- to Long-Term neurodevelopment in preterm infants: An overview].

Gynecologie, obstetrique, fertilite &amp; senologie
2026

The Gut as a Source of Infection for Fungal Pathogens: Increased Fecal Candida albicans Precedes Onset of Candida Late-Onset Sepsis in Very Preterm Infants.

The Journal of infectious diseases
2025

Four-factor nomogram for early-onset sepsis in preterm neonates: Development and internal validation of a stewardship tool.

PloS one
2025

Lupus pneumonitis in neonatal lupus: a case report.

Journal of medical case reports
2025

Awareness of neonatal heat illness: a fatal outcome in a late preterm infant.

BMJ case reports
2025

Milk temperature reducing necrotizing enterocolitis in very preterm infants: study protocol for a randomized controlled trial.

BMC pediatrics
2025

Fulminant neonatal listeriosis with death within 24 hours in a preterm infant: a case report.

BMC infectious diseases
2026

Urinary immune biomarkers for late-onset sepsis in preterm very low birth weight neonates - a diagnostic accuracy study.

Journal of perinatal medicine
2025

Impact of fast advancement and early fortification of enteral feedings in preterm infants, a retrospective, observational study.

Frontiers in pediatrics
2025

ESBL-producing Klebsiella pneumoniae gut colonisation and subsequent health-care associated bacteraemia in preterm newborns: a descriptive cohort with nested case-control study.

Epidemiology and infection
2025

Central line-associated blood stream infections in newborns: From vulnerability to prevention.

Seminars in fetal &amp; neonatal medicine
2025

The intersection of cervicovaginal microbiota and cervical length in predicting adverse perinatal outcomes at preterm birth risk.

BMC pregnancy and childbirth
2025

Probiotic supplementation - does it prevent or cause neonatal sepsis?

Seminars in fetal &amp; neonatal medicine
2025

The added value of the sFlt-1/PlGF ratio in pregnant women with intrauterine growth restriction (IUGR) with or without preeclampsia on adverse pregnancy outcomes and neonatal morbidities: a retrospective study.

BMC pregnancy and childbirth
2025

Use of WHO quality assessment/quality improvement tool for maternal and newborn care for gap analysis and POCQI methodology to improve preterm neonatal outcomes at a tertiary care centre: a quality improvement initiative.

BMJ open quality
2025

Postnatal weight gain of premature small for gestational age versus appropriate for gestational age infants during NICU stay.

Journal of tropical pediatrics
2026

Application of Umbilical Cord Blood for the Clinical Prevention and Treatment of Complications in Preterm Infants(Review).

Stem cell reviews and reports
2025

The Development of Enterovirus Sepsis Syndrome in a Preterm Neonate: A Case Report.

Advances in neonatal care : official journal of the National Association of Neonatal Nurses
2025

Characterization of gut microbiota signatures in Indian preterm infants with necrotizing enterocolitis: a shotgun metagenomic approach.

Frontiers in cellular and infection microbiology
2025

Outcome trends in preterm infants with incomplete antenatal corticosteroid cycles: Is 6 h enough?

European journal of obstetrics, gynecology, and reproductive biology
2025

Predicting Neonatal Morbidity and Correlations with Maternal and Neonatal Biomarkers in Connection with Fetal Inflammatory Response Syndrome in Premature Births.

Journal of clinical medicine
2025

Shared immune biomarkers in necrotizing enterocolitis and neonatal sepsis identified via bioinformatics and machine learning.

Scientific reports
2026

Recurrence of apnea of prematurity following early discontinuation of caffeine: A prospective analytical study.

Journal of neonatal-perinatal medicine
2025

The effect of preterm premature rupture of membranes on neonatal outcomes in low-birth-weight infants: a retrospective study.

The journal of maternal-fetal &amp; neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2025

Antenatal Corticosteroid in Twin-Pregnant Women at Risk of Late Preterm Delivery: A Randomized Clinical Trial.

JAMA pediatrics
2025

Case Report: Pericardial effusion in late onset neonatal Escherichia coli sepsis.

F1000Research
2025

Probiotics for preventing neonatal sepsis in preterm neonates: a systematic review and meta-analysis for clinical practice.

Epidemiology and health
2025

The species and load of gastric bacteria at birth correlate with inflammation severity in very preterm infants.

Pediatrics international : official journal of the Japan Pediatric Society
2025

Individualized Prediction of Platelet Transfusion Outcomes in Preterm Infants With Severe Thrombocytopenia.

JAMA
2025

Candida guilliermondii candidemia: A rare finding in a neonate with necrotizing enterocolitis.

Indian journal of medical microbiology
2025

Factors associated with weight Z-score in very low birth weight and extremely low birth weight preterm infants during hospitalization.

Jornal de pediatria
2025

Successful percutaneous retrieval of fractured umbilical artery catheter in a very low birth weight preterm neonate.

The Turkish journal of pediatrics
2025

Respiratory Outcomes Following Late Postnatal Dexamethasone Administration in Preterm Infants With Bronchopulmonary Dysplasia.

Pediatric pulmonology
2025

Corynebacterium amycolatum: an underestimated pathogen in early-onset neonatal sepsis-a case report.

BMC infectious diseases
2025

Prematurity, Neonatal Complications, and the Development of Childhood Hypertension.

JAMA network open
2025

Face mask versus nasal mask device use for initial resuscitation in extremely and very preterm infants (FONDUE): an open-label, single-centre, randomised, controlled trial.

The Lancet. Child &amp; adolescent health
2025

Herpes simplex virus disease in infants younger than 90 days: a British Paediatric Surveillance Unit study.

Archives of disease in childhood
2025

Association of maternal infections, antibiotic use, and cesarean delivery with the risk of early-onset sepsis: a nationwide population-based study in full-term neonates.

BMC pregnancy and childbirth
2025

Neonatal listeriosis complicated by prematurity and neurological sequelae.

BMJ case reports
2025

Antibody dependent complement activation is critical for boosting opsonophagocytosis of Staphylococcus epidermidis in an extremely preterm human whole blood model.

Scientific reports
2025

A Case Series of Iatrogenic Gastrointestinal Perforations in Premature Infants Below 30 Weeks' Gestation.

Journal of pediatric surgery
2025

Microorganisms identified in neonatal sepsis and their antimicrobial resistance in a hospital in Western Mexico.

Boletin medico del Hospital Infantil de Mexico
2025

Intravenous Ceftaroline in Extremely Premature Neonates With Coagulase-Negative Staphylococci Septicemia: A Report of 2 Cases.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
2025

Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants.

Nature communications
2025

Outcomes after cerclage and preterm prelabor rupture of membranes: data from the international collaborative for cerclage longitudinal evaluation and research (IC-CLEAR).

American journal of obstetrics &amp; gynecology MFM
2025

[WHO recommendation on screening of pregnant women for intrapartum antibiotic prophylaxis for the prevention of early onset Group B streptococcus disease in newborns].

Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))
2025

Consequences of host-microbiome interactions in preterm infants.

Infection and immunity
2025

Enteral vitamin a supplementation for the prevention of bronchopulmonary dysplasia in preterm infants: an updated systematic review and meta-analysis.

Annals of medicine and surgery (2012)
2025

Controversies in the diagnosis and management of preterm prelabour rupture of the membranes.

European journal of obstetrics, gynecology, and reproductive biology
2025

Open repair versus fetoscopic fetal surgery: Which is the best approach for intrauterine myelomeningocele correction? Systematic review and meta-analysis.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2025

Effect of Intrapartum Antibiotic Exposure Time on Neonatal Sepsis: A Prospective Cohort Study.

Indian pediatrics
2025

Enteral feeding based on expected median weight versus actual weight among small for gestational age preterm infants born at 30-34 weeks of gestation for prevention of hypoglycemia: an assessor-blinded randomised controlled trial.

European journal of pediatrics
2025

Epidemiological Profile of Retinopathy of Prematurity in Central India.

Cureus
2025

[Impact of donor human milk bank on clinical outcomes in infants with very/extremely low birth weight].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
2025

Incidence and predictors of preterm neonatal mortality at public hospitals in Eastern Ethiopia: A prospective follow-up study.

PloS one
2025

Neonatal Outcomes of the Intubation-Surfactant-Extubation versus Less Invasive Surfactant Administration Method: A National Cohort Study in Korea.

Neonatology
2025

Absence of Evidence of Beneficial Effects of Human Milk-Based Fortifier: A Bayesian Model-Averaged Meta-Analysis.

Acta paediatrica (Oslo, Norway : 1992)
2025

Clinical Presentation of Postnatally Acquired Cytomegalovirus Infection in Preterm Infants-A Case Series Report.

Children (Basel, Switzerland)
2025

Pulmonary Hemorrhage in Premature Infants: Pathophysiology, Risk Factors and Clinical Management.

Biomedicines
2025

Unravelling non-communicable diseases among pregnant women in a lower-middle-income country and the feto-maternal outcomes: a descriptive cross-sectional study.

BMJ open
2025

Neonatal outcomes following previable rupture of membranes below 23 weeks' gestation.

European journal of pediatrics
2026

Progesterone in pregnancy and neonatal outcomes: A systematic review and meta-analysis of randomized controlled trials.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
2025

The Effect of Oral Immunotherapy on Preterm Neonates: A Promising Adjuvant Therapy in a Clinical Trial Study.

Neonatology
2025

Expert review of CLABSI prevention in the NICU: supporting the transition of investigational drugs into clinical practice.

European journal of pediatrics
2026

Variations in antibiotic use in late preterm and term newborns from 2012 to 2020: a nationwide population-based observational study.

Archives of disease in childhood. Fetal and neonatal edition
2025

Adverse perinatal outcomes associated with respiratory distress syndrome in preterm infants: a retrospective analysis.

Italian journal of pediatrics
2025

Association of timing of initial breastfeeding and neonatal outcome in very preterm infants: a multicentre cohort study in China.

BMJ paediatrics open
2025

Risk Factors for Hearing Loss Are Comparable in Preterm Versus Term Children: A Systematic Review.

Acta paediatrica (Oslo, Norway : 1992)
2025

Intrauterine inflammation exposure may increase the risk of late-onset sepsis in premature infants: a retrospective cohort study.

Italian journal of pediatrics
2025

Candidemia caused by Candida haemulonii: a case report and literature review in neonates.

Revista do Instituto de Medicina Tropical de Sao Paulo
2025

Maternal and Neonatal Outcomes in Pregnancies with Adenomyosis.

Maternal and child health journal
2025

The effect of vitamin supplementation on neurodevelopmental and clinical outcomes in very low birth weight and very preterm infants: A systematic review and meta-analysis.

PloS one
2025

Development and validation of a nomogram model for predicting the occurrence of necrotizing enterocolitis in premature infants with late-onset sepsis.

European journal of medical research
2025

Intraventricular haemorrhage, associated factors and mortality among very low birth weight neonates admitted at Muhimbili National Hospital, Dar es Salaam, Tanzania: a prospective cohort study.

Italian journal of pediatrics
2025

Source-tracking Klebsiella outbreaks in premature infants using a novel amplicon fingerprinting method.

Antimicrobial resistance and infection control
2025

Comparative outcomes of spontaneous intestinal perforation and necrotising enterocolitis in preterm infants: a retrospective cohort study from Saudi Arabia.

BMJ paediatrics open
2025

Association between late parenteral nutrition initiation and length of hospital stay in late preterm and term infants: A retrospective cohort study.

JPEN. Journal of parenteral and enteral nutrition
2025

Current state of microbiota clinical applications in neonatal and pediatric bacterial infections.

Gut microbes
2025

Late-onset sepsis treatment in very preterm infants alters longitudinal microbiome trajectory with lower abundance of Bifidobacterium despite probiotic supplementation.

Gut microbes
2025

Factors influencing early surgical outcomes of intestinal atresia in a resource-limited tertiary center.

Pediatric surgery international
2025

[Quantitative and qualitative indicators of neonatological care at the Maternity Private Obstetric and Gynecologic Hospital in 2023].

Orvosi hetilap
2025

Bibliometric analysis of sepsis and gut microbiota: Trends from 2014 to 2024.

Frontiers in microbiology
2025

Peripheral Multilineage Haemophagocytosis in an Extremely Premature Infant With Escherichia col i Sepsis.

EJHaem
2025

FoCUS and non-invasive hemodynamics monitoring in neonatal sepsis.

European journal of pediatrics
2025

Count of Neonatal Morbidities Predicts Outcomes at Age 10 and 15 Years in Infants Born Extremely Preterm.

The Journal of pediatrics
2025

Antenatal corticosteroid exposure and neonatal outcomes in term infants.

Early human development
2026

Preterm meconium-stained amniotic fluid: A red flag for infection and adverse perinatal outcomes.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
2025

Impact of fetal inflammatory response on brain MRI abnormalities in extremely preterm infants.

Pediatric research
2025

Streptococcus pyogenes in Neonates and Postpartum Women: First Report on Prevalence, Resistance, emm Typing, and Risk Factors in Khyber Pakhtunkhwa.

Polish journal of microbiology
2025

Staphylococcus haemolyticus is a reservoir of antibiotic resistance genes in the preterm infant gut.

Gut microbes
2025

Safety and feasibility of allogeneic cord blood-derived cell therapy in preterm infants with severe brain injury (ALLO trial): a phase-1 trial protocol.

BMJ open
2025

Trends in short-term outcomes of very low birth weight infants from a single center in Shanghai from 2013 to 2023.

Translational pediatrics
2025

Prophylactic hydrocortisone and the risk of sepsis in neonates born extremely preterm.

European journal of pediatrics
2025

Evaluation of Bovine Lactoferrin for Prevention of Late-Onset Sepsis in Low-Birth-Weight Infants: A Double-Blind Randomized Controlled Trial.

Nutrients
2025

Oral vitamin D supplementation is associated with full enteral feeding in very low birth weight infants.

The journal of maternal-fetal &amp; neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2025

Cord blood proteomics identifies biomarkers of early-onset neonatal sepsis.

JCI insight
2025

Associations between antibiotic exposure intensity, intestinal microbiome perturbations, and outcomes in premature neonates with bacteremia.

Journal of perinatology : official journal of the California Perinatal Association
2025

Breast milk pasteurization for preventing cytomegalovirus infection: A preliminary study in a Japanese perinatal center.

Pediatrics international : official journal of the Japan Pediatric Society
2026

Adverse neurodevelopment after multiple sepsis and/or necrotizing enterocolitis in preterm infants: revisiting single-episode paradigm.

Pediatric research
2025

Association between parenteral nutrition and length of stay in late preterm and term infants: A retrospective cohort study.

JPEN. Journal of parenteral and enteral nutrition
2025

Late-onset Carbapenem-resistant Enterobacteriaceae Sepsis Among Very Preterm Infants: A Multicenter Study in China.

The Pediatric infectious disease journal
2025

Expectant management of late preterm prelabor rupture of membranes in GBS carriers.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
2025

[Comparative analysis of clinical characteristics of term and preterm neonates with necrotizing enterocolitis undergoing surgery].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
2025

Environmental investigation of 10 cases of nosocomial Bacillus cereus bacteraemia between 2018 and 2023.

Antimicrobial resistance and infection control
2025

A study protocol for neonatal sepsis and gut microbiomics among preterm infants admitted at Muhimbili National Hospital, Tanzania.

PloS one
2025

Antenatal dexamethasone for late preterm delivery: Rate of complete course and neonatal outcomes.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Can topical coconut oil reduce late-onset sepsis in extremely preterm infants? A pragmatic cluster-randomised controlled trial protocol.
    BMJ open· 2026· PMID 41781050mais citado
  2. Drying Very Preterm Infants Before Plastic Wrapping at Birth: A Randomized Clinical Trial.
    JAMA network open· 2026· PMID 41774445mais citado
  3. Hospital-Acquired Citrobacter Meningitis Complicated by Pneumocephalus in a Neonate.
    Pediatrics· 2026· PMID 41734809mais citado
  4. Immune profiles and growth outcomes in very and extremely preterm infants with bronchopulmonary dysplasia: A prospective cohort study.
    Pediatrics and neonatology· 2026· PMID 41611561mais citado
  5. S100-alarmins, antenatal corticosteroids and the risk of late-onset sepsis in preterm infants: A prospective cohort study.
    PloS one· 2026· PMID 41591973mais citado
  6. Evaluation of Patients With Pulmonary Hemorrhage in a Tertiary Neonatal Intensive Care Unit in Türkiye.
    Pediatr Pulmonol· 2026· PMID 41853879recente
  7. Epidemiological Profile of Neonates Admitted to a Neonatal Intensive Care Unit in Tertiary Care Referral Center of Nepal: A Four Years Cross Sectional Study.
    J Nepal Health Res Counc· 2026· PMID 41851945recente
  8. Methicillin Resistant Staphylococcus Aureus Colonization, The Tip of the Iceberg for Congenital Pulmonary Airway Malformation. A Case Report.
    Clin Ter· 2026· PMID 41773355recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:90051(Orphanet)
  2. Busca completa no PubMed(PubMed)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Sepse de apresentação tardia em lactentes prematuros
Compêndio · Raras BR

Sepse de apresentação tardia em lactentes prematuros

ORPHA:90051
Prevalência
1-5 / 10 000
Herança
Not applicable
CID-10
P36.0 · Septicemia do recém-nascido devida a estreptococo do grupo B
CID-11
Início
Neonatal
Prevalência
32.0 (Europe)
UMLS
C5681350
Repurposing
3 candidatos
delivertangiotensin receptor agonist
gentamycinbacterial 50S ribosomal subunit inhibitor
silver-sulfadiazinePABA antagonist
EuropePMC
DiscussaoAtiva

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