Síndrome de polineuropatia-perturbação do desenvolvimento intelectual-acromicria-menopausa precoce

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Hospital de Apoio de Brasília (HAB)

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Hospital de Clínicas da UFPR

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Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira (IFF/Fiocruz)

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Hospital de Clínicas de Porto Alegre (HCPA)

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Hospital das Clínicas da FMUSP

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Hospital de Clínicas da UNICAMP

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Hospital de Clínicas de Ribeirão Preto (HCRP-USP)

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(16) 3602-1000 Site 4.6

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences2026 Mar 17

Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

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Timeline de publicações

0 papers (10 anos)

#1

Design and in vitro/in vivo evaluation of a compound estradiol-progesterone patch for the treatment of menopausal syndrome.

Transdermal estradiol patches have been widely used for the prevention and treatment of ovarian insufficiency. However, they should not be used alone and must be combined with adequate progestin therapy for a full course to provide sufficient endometrial protection. This study aimed to develop a compound estradiol-progesterone transdermal patch by incorporating progesterone into the estradiol patch to reduce the number of medications administered, and to evaluate its feasibility and efficacy. Key excipients in the patch, including pressure-sensitive adhesive, permeation enhancers, and plasticizers, were screened and optimized. The optimal patch formulation was selected based on evaluation criteria including adhesion, cumulative release rate, cumulative permeation, and appearance. Subsequently, a menopausal rat model was established to conduct single-dose pharmacokinetic studies and multiple-dose pharmacodynamic evaluations, comparing results with a commercial estradiol patch and progesterone injection. Results demonstrated that the prepared patches exhibited good conformability and adhesion. The cumulative release rate of E2 over 72 hours was 94.58%, with a cumulative permeation rate of 154.56 μg·cm-2 over 24 hours. These results are comparable to those of commercially available estradiol patches, which exhibit a 72-hour cumulative release rate of 90.02% and a 24-hour cumulative permeation rate of 148.69 μg·cm-2. P4 exhibited a 72-hour cumulative release rate of 92.45% and a 24-hour cumulative permeation rate of 104.92 μg·cm-2, achieving the clinically effective dose threshold. The time to peak concentration and residence time for a single application were longer than those of ESTRANA® Tapes and progesterone injection. Compared with the model group, the combined administration group showed a significantly increased uterine coefficient without the abnormal endometrial thickening observed after using estradiol patches alone. This patch achieves synchronized delivery of estrogen and progesterone, meeting the clinical demand for long-acting hormone therapy.

#2

Efficacy and security of traditional Chinese medicine in the treatment of perimenopausal insomnia in the Chinese population: a systematic review and meta-analysis of randomized controlled trials.

Frontiers in neurology2026

Traditional Chinese medicine (TCM) has been widely applied in the management of perimenopausal insomnia (PMI), yet comprehensive evidence on its efficacy and safety remains insufficient. We aimed to systematically evaluate the therapeutic effects and safety of TCM interventions in PMI treatment. Randomized controlled trials (RCTs) that compared TCM interventions with Western medicine for patients with PMI were searched across eight databases from inception to August 1, 2025. Methodological quality, risk of bias, and certainty of evidence were assessed using the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines and Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework. Meta-analysis was performed using RevMan 5.4 and R 4.4.2 software. A total of 48 RCTs involving 5,037 patients were included. Meta-analysis showed that TCM was superior to Western medicine in overall efficacy (RR = 1.20, 95% CI [1.17, 1.23]) and had fewer adverse reactions (RR = 0.30, 95% CI [0.24, 0.38]). Besides, TCM interventions significantly improved Pittsburgh Sleep Quality Index (PSQI) score (MD = -2.57, 95% CI [-3.01, -2.14]), reduced luteinizing hormone (LH) (MD = -4.51, 95% CI [-6.15, -2.87]) and follicle-stimulating hormone (FSH) (MD = -8.67, 95% CI [-10.96, -6.38]), increased estradiol (E2) level (MD = 9.64, 95% CI [7.45, 11.82]), and decreased Kupperman Menopausal Index (KMI) score (MD = -6.01, 95% CI [-8.56, -3.47]), Traditional Chinese Medicine Syndrome (TCMS) score (SMD = -2.27, 95% CI [-3.49, -1.05]), Self-Rating Anxiety Scale (SAS) score (MD = -4.77, 95% CI [-5.77, -3.76]), and Self-Rating Depression Scale (SDS) score (MD = -2.96, 95% CI [-5.80, -0.12]). TCM interventions demonstrate notable efficacy and safety in managing PMI by improving sleep quality, hormonal balance, and mental health. However, methodological limitations and heterogeneity warrant further validation through large-scale, multicenter, rigorously designed RCTs. PROSPERO registration number CRD420251127129.

#3

Impact of fractional CO2 laser therapy on vaginal wall histology in breast cancer survivors.

Lasers in medical science2026 Feb 10

To investigate histological changes in the vaginal wall of breast cancer survivors (BCSs) with genitourinary syndrome of menopause (GSM) treated with five sessions of fractional CO₂ vaginal laser therapy, focusing on epithelial morphology and stromal extracellular matrix composition. In this prospective single-center study, 26 BCSs underwent five sessions of fractional CO2 vaginal laser therapy. Vaginal punch biopsies were collected at baseline and four to six weeks after completing the final session. Mucosal morphology was classified (Type 1, 2, or 3) independently by two pathologists, blinded to baseline and follow-up status. Stromal elastin, total collagen, and collagen types I and III were quantified by digital image analysis of Verhoeff-Van Gieson, Masson's trichrome, and immunohistochemistry. Paired tests and the Stuart-Maxwell test evaluated changes over time. At baseline, 42.3% of participants were classified as Type 1, 19.2% as Type 2, and 38.5% as Type 3 mucosal morphology. Elastin index increased from 33.1% to 56.8% (p < 0.01), and collagen type III index from 44.5% to 58.4% (p = 0.03), while total collagen and collagen type I showed no significant change. No significant differences in epithelial microscopic features were observed (Stuart-Maxwell p = 0.16). Fractional vaginal CO₂ laser therapy was associated with selective stromal remodelling in BCSs - higher elastin and collagen type III indices, but without detectable improvement in epithelial morphology. Given the absence of a control group, the short follow-up, and limited epithelial morphometry due to section orientation, these findings should be interpreted as preliminary histological evidence of a stromal response rather than a confirmation of functional or regenerative benefit. Registry: ClinicalTrials.gov, TRN: (NCT06007027). Registration date: 1 August 2023.

#4

Effect of Bioptron light therapy on dryness of eyes in postmenopausal women: a randomized controlled trial.

Lasers in medical science2026 Feb 04

To examine the short-term therapeutic effects of Bioptron light therapy (BLT) on dry eye disease (DED) in postmenopausal women. Sixty postmenopausal women diagnosed with DED, aged 50-62 years with a body mass index ≤ 30 kg/m², were randomly assigned to two equal groups. The Bioptron group (n = 30) received BLT for 10 min, twice weekly, along with an educational program for four weeks. The control group (n = 30) received the same educational program only. Outcomes were measured using Schirmer's test (Schirmer I) for basal tear secretion, Tear Break-Up Time (TBUT) for tear film stability, and the Dry Eye-related Quality of Life Score (DEQS) for quality of life (QOL). Both groups exhibited significant improvements post-treatment compared to pre-treatment in all variables, with greater percentage changes from baseline in the BLT group. Between-group comparisons revealed significantly higher improvements in the BLT group: Schirmer's test (Schirmer I) improved by MD = 8.7 (95% CI: 7.64-9.76; p = 0.001), TBUT by MD = 2.97 (95% CI: 1.7-4.3; p = 0.007), and DEQS decreased by MD = - 24.1 (95% CI: -37 to - 17.1; p = 0.002). Compared with standardized education alone, adjunctive Bioptron light therapy significantly enhanced tear secretion, tear film stability, and patient-reported symptoms, suggesting its potential as an effective non-pharmacological option for managing dry eye in postmenopausal women. The trial was registered at Clinical Trials.gov (Identifier: NCT05964673).

#5

Acute Coronary Syndromes in Premenopausal Women: A Scientific Statement From the American Heart Association.

Circulation2026 Feb 17

Premenopausal women presenting with acute coronary syndrome (ACS) are a unique and often underrecognized patient population. Although they are traditionally considered at lower cardiovascular risk than other groups, we have begun to appreciate the potential risk for ACS in this younger subset of women. Whereas atherosclerotic disease (obstructive or nonobstructive) accounts for most presentations, a substantial number are attributable to nonatherosclerotic causes, including spontaneous coronary artery dissection, epicardial coronary artery spasm, and coronary embolism. A major challenge at present is the lack of specific data and evidence for the diagnosis and management of these women. Unfortunately, as a result of several factors, diagnostic delays, misclassification, and mistreatment appear to be more frequent than for other patient groups. Of great concern, younger women less often receive guideline-directed therapies after ACS, and younger women with ACS have been shown to have worse outcomes than young men with ACS. Management should be tailored to the unique pathophysiology in premenopausal women, emphasizing early diagnosis, a low threshold for invasive angiography if appropriate, and special consideration in the pregnant patient. Secondary prevention must address traditional cardiovascular and disease-specific risk factors, with consideration of current or future pregnancies and lactation. Participation in cardiac rehabilitation is associated with improved outcomes and must be strongly encouraged, whereas attention to potential post-ACS depression and anxiety is an important aspect of holistic care. Increased patient and health care professional awareness and improved representation in research are critical to closing the knowledge and outcome gaps in premenopausal women with ACS.

Publicações recentes

Short-term outcomes and tolerability of a hyaluronic acid-based vaginal gel in the management of genitourinary syndrome of menopause: a retrospective observational study.

Gynecol Endocrinol2026 Dec 31

Vaginal pixel CO2 laser versus topical use of promestriene for genitourinary syndrome of menopause.

Rev Bras Ginecol Obstet2026

Treating Genitourinary Syndrome of Menopause in Postmenopausal Women with a History of Breast Cancer.

Drugs Aging2026 Mar

Female Underweight/Undernutrition Syndrome (FUS): An Emerging Health Concept in Premenopausal Women - Secondary Publication (English Translation of the Japanese Statement).

J Obstet Gynaecol Res2026 Feb

Effectiveness of radiofrequency therapy combined with pelvic floor muscle training in breast cancer survivors with genitourinary syndrome of menopause: a study protocol.

Eur J Obstet Gynecol Reprod Biol2026 Mar 25

Ver todas no PubMed

📚 EuropePMCmostrando 200

Therapeutische Umschau. Revue therapeutique

[Preventing dementia in an ageing society].

International journal of women's health

Proteolytic Imbalance of the MMP/E-Cadherin Axis in Genitourinary Syndrome of Menopause: A Cross-Sectional Study.

American journal of lifestyle medicine

Lifestyle and Complementary Approaches to Polycystic Ovary Syndrome During Perimenopause and Menopause A Scoping Review.

Safety of vaginal estrogen in breast cancer survivors: Current evidence on systemic absorption and oncologic outcomes.

Frontiers in reproductive health

Fractional CO2 laser therapy for genitourinary syndrome of menopause: symptom-specific trajectories, exposure-outcome associations, and ultrasonographic changes in vulvar soft tissue in a cohort of 826 women.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Design and in vitro/in vivo evaluation of a compound estradiol-progesterone patch for the treatment of menopausal syndrome.

Public health in practice (Oxford, England)

Global trends in psychosexual and emotional health challenges among breast cancer survivors (1999-2024): Implications for public health and survivorship care.

Biomolecules & biomedicine

Polycystic ovary syndrome and risk of endometrial hyperplasia and endometrial cancer in women with abnormal uterine bleeding: A systematic review and meta-analysis.

Journal of integrative medicine

Anxiolytic, anti-depressive and cognition-enhancing effects of total saponins from lily bulbs in ovariectomized mice: A potential therapy for menopause-associated emotional disorders.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

Short-term outcomes and tolerability of a hyaluronic acid-based vaginal gel in the management of genitourinary syndrome of menopause: a retrospective observational study.

Journal of obstetric, gynecologic, and neonatal nursing : JOGNN

Potential Harm of the Use of the Word "Benign" in Gynecologic Care.

Diode Laser and Radiofrequency for Genitourinary Syndrome of Menopause: A Comparative Analysis.

Intra-Individual Variability of Lipoprotein(a) After Acute Coronary Syndrome: A Long-Term Cohort Study.

Radiofrequency versus vaginal estrogen for menopausal sexual dysfunction: a systematic review and meta-analysis of randomized clinical trials.

Sexual medicine reviews

The Role of the Vaginal Microbiome in Gynecological Diseases: Mechanistic Insights and Emerging Interventions.

Biology

Innovative mitochondria-based holistic 3PM approach to female health status: Facts and outlook.

The EPMA journal

Frontiers in endocrinology

Circulating vitamin D and follicle-stimulating hormone levels are associated with subclinical atherosclerosis in climacteric women with menopausal syndrome.

The tight bond between Fanconi anemia and aging.

Frontiers in aging

Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia

Vaginal pixel CO2 laser versus topical use of promestriene for genitourinary syndrome of menopause.

Obesity and female reproductive health in Asian population.

Obesity pillars

Hidden Cardiovascular Risk: Early Menopause Triggering Acute Coronary Syndrome (ACS) in Young Patients.

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Effects and mechanisms of Renshen Guben Oral Liquid combined with Jingfang Granules on ovarian aging in perimenopausal mice].

Climacteric : the journal of the International Menopause Society

Comparison of menopausal symptoms in women with and without type 2 diabetes mellitus: a cross-sectional study.

Climacteric : the journal of the International Menopause Society

Reproductive potential in mosaic Turner syndrome: impact of karyotype pattern and mosaicism ratio.

Development and bioavailability testing of an estetrol and estetrol-zinc-containing vaginal hydrogel: a novel hydroxyethyl cellulose and hydroxypropyl-β-cyclodextrin-based formulation.

Aesthetic surgery journal

Erbium:YAG Laser Combined With Plant-Derived Exosomes (ASCEplus IRLV) for Genital Rejuvenation.

Efficacy and security of traditional Chinese medicine in the treatment of perimenopausal insomnia in the Chinese population: a systematic review and meta-analysis of randomized controlled trials.

Frontiers in neurology

From bench to bedside: unlocking the anti-inflammatory, antioxidant, and anticancer promise of curcumin in gynecology.

Frontiers in medicine

JNMA; journal of the Nepal Medical Association

Dry Eye in Post-menopausal Women Visiting Community Eye Centre: An Observational Study.

Sex hormones and arrhythmia risk in women with long QT syndrome.

Heart rhythm

Climacteric : the journal of the International Menopause Society

The association between smoking and joint pain in women attending a specialized menopause clinic.

Treating Genitourinary Syndrome of Menopause in Postmenopausal Women with a History of Breast Cancer.

Drugs & aging

Postural Orthostatic Tachycardia Syndrome, Menopause and Hormone Replacement Therapy: Clinical Decisions in Times of Uncertainty.

Vulvovaginal Collagen Injection as a Regenerative Strategy in Genitourinary Syndrome of Menopause: Results of a Pilot Study.

Therapeutic advances in reproductive health

A mixed-method analysis of health literacy and indicators of well-being in women with polycystic ovary syndrome across the lifespan.

Liver international : official journal of the International Association for the Study of the Liver

Effect of Hormone Replacement Therapy on Liver and Cardiometabolic Outcomes in Peri-Menopausal MASLD.

Journal of ethnopharmacology

Yinhuo Decoction attenuates depression-like behaviors and promotes M2 microglia polarization by regulating PI3K/Akt/NF-κB signaling pathway in a murine model of menopausal depression.

The journal of obstetrics and gynaecology research

Female Underweight/Undernutrition Syndrome (FUS): An Emerging Health Concept in Premenopausal Women - Secondary Publication (English Translation of the Japanese Statement).

Association between reproductive span and postmenopausal metabolic syndrome: a cross-sectional study in China.

Postoperative Management After Risk-Reducing Salpingo-Oophorectomy for Hereditary Breast and Ovarian Cancer Syndrome: A Narrative Review on Balancing Oncologic Benefit and Quality of Life.

[Menopausal hormone therapy in patients with cardiovascular and metabolic diseases: an interdisciplinary Delphi consensus among Russian gynecologists, cardiologists, endocrinologists, gerontologists and geriatricians, phlebologists, and clinical pharmacologists].

Terapevticheskii arkhiv

Expert review of endocrinology & metabolism

Skin deep: dermatologic challenges in PCOS through the female lifespan.

American journal of obstetrics and gynecology

Altered microbial colonization of the urogenital tract in female overactive bladder syndrome.

Sangyo eiseigaku zasshi = Journal of occupational health

[A pilot study on health issues, literacy, and presenteeism related to male menopause among working Japanese men].

European journal of obstetrics, gynecology, and reproductive biology

Effectiveness of radiofrequency therapy combined with pelvic floor muscle training in breast cancer survivors with genitourinary syndrome of menopause: a study protocol.

Topical hyaluronic acid and oxygen for urinary incontinence: a double-center retrospective study.

Frontiers in medicine

Gut microbiota and metabolic syndrome in postmenopausal women: a narrative review of mechanisms and dietary recommendations.

Minerva endocrinology

Current opinion in obstetrics & gynecology

Menopausal hormone therapy and breast cancer: risk and management.

Journal of bone and mineral metabolism

How postmenopausal osteoporosis influences epidemiology and clinical features of CRPS-1.

Lasers in medical science

Impact of fractional CO2 laser therapy on vaginal wall histology in breast cancer survivors.

Efficacy of nonablative radiofrequency on sexual function in postmenopausal women: a randomized clinical trial.

BJOG : an international journal of obstetrics and gynaecology

Risk of Cancer With Hormone Replacement Therapy: A Narrative Review.

Diabetes research and clinical practice

Reproductive factors, insulin resistance surrogate indices, and circadian syndrome among middle-aged and elderly women a mediation analysis using two-national cohorts.

Clinical and experimental medicine

Sex and menopause-based differences in presentation of early Lyme disease: A prospective cohort study.

Frontiers in public health

Post-licensure safety surveillance of 9-valent human papillomavirus vaccine using the vaccine adverse event reporting system, 2014-2024.

Current opinion in obstetrics & gynecology

The new toolbox for reducing painful sex in menopause.

Safety and Impacts of Physical Activity for Individuals Living With Hypermobility Spectrum Disorders and Hypermobile Ehlers-Danlos Syndrome: Protocol for a Scoping Review.

JMIR research protocols

Lasers in medical science

Effect of Bioptron light therapy on dryness of eyes in postmenopausal women: a randomized controlled trial.

Continuum (Minneapolis, Minn.)

Neurologic Complications of Pregnancy and Menopause.

Acute Coronary Syndromes in Premenopausal Women: A Scientific Statement From the American Heart Association.

Circulation

Comparative effectiveness of different acupuncture therapies for perimenopausal syndrome: a systematic review and network meta-analysis.

Frontiers in neurology

Vaginal vitamin D for Genitourinary syndrome of menopause: a cohort study and literature review.

Future science OA

Current opinion in obstetrics & gynecology

A review of estrogens used in menopausal hormone therapy.

Understanding patient priorities: Sexual health and hereditary ovarian cancer syndromes.

Gynecologic oncology

Aesthetically relevant symptoms of menopause transition: Impact and approach to management.

Clinics in dermatology

Research in pharmaceutical sciences

The effect of estradiol and selective estrogen receptor modulators on lipid profile in the ovariectomized rat model.

Effects of 12-week aquatic HIIT on blood pressure lipid profile and BaPWV in postmenopausal women with different ACE genotypes.

Case Report: Postmenopausal hyperandrogenism misled by adrenal incidentaloma: a rare case of androgen-secreting ovarian adult granulosa cell tumor and clinical implications.

Frontiers in oncology

Late Cervical Recurrence of Invasive Lobular Carcinoma Ten Years After Primary Breast Cancer: A Case Report and Review of the Literature.

Diagnostics (Basel, Switzerland)

The Relationship Between Bone Health Status of Post-Menopausal Women with Non-Functional Adrenal Tumours/Mild Autonomous Cortisol Secretion and Their Baseline Morning Adrenocorticotropic Level.

Intravaginal dehydroepiandrosterone for the treatment of vulvovaginal atrophy: a systematic review and meta-analysis.

Decision-making surrounding ovarian cancer risk-reducing surgery: perspectives from a diverse population.

Journal of dental sciences

Effects of ovariectomy of rat on tongue neuropathy: Relevance to burning mouth syndrome.

[Optical Coherent Tomography: A Tool for Non-Invasive Biopsy in Women's Health].

Harefuah

Biomedical and environmental sciences : BES

Associations between Premature Menopause and Cardiovascular-Kidney-Metabolic Syndrome: A Prospective Cohort Study from the UK Biobank.

Hormone Replacement Therapy and Cardiovascular Outcomes by Race and Ethnicity: MESA (Multi-Ethnic Study of Atherosclerosis).

JACC. Advances

Triglyceride-glucose index and cardiovascular disease by cardiovascular-kidney-metabolic syndrome and socioeconomic status among postmenopausal women.

Atherosclerosis

Gynecologie, obstetrique, fertilite & senologie

[Clinical and histological evaluation of fractional CO2 laser treatment for genitourinary syndrome of menopause].

Annals of African medicine

Hereditary Risk Assessment of Cancer Using Clinical History in Patients Diagnosed with Breast or Ovarian Cancer Receiving Treatment at Tertiary Care Hospital in Western Rajasthan - A Cross-sectional Study.

Frontiers in neuroendocrinology

From menarche to menopause: estrogenic influences on stroke-related depression in women.

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)

The uptake rate of risk-reducing salpingo-oophorectomy among Thai women with breast cancer and germline BRCA pathogenic or likely pathogenic variants.

Journal of gynecology obstetrics and human reproduction

Evaluation of symptom improvement over time after fractional CO2 laser therapy in women with genito-urinary syndrome.

Clinical pharmacology and therapeutics

Quantitative Systems Toxicology Modeling with DILIsym to Support Phase 3 Dose Selection for Fezolinetant.

Atypical Polypoid Adenomyoma in a Patient with Hyperprolactinemia: a Novel Case and Systematic Review of the Systematic Reviews.

Maedica

Beyond malignancy: Unravelling the Enigma of Meigs syndrome in ovarian fibroma.

Tropical doctor

Phytotherapy research : PTR

Ingenol-Mediated SIRT1-LXRα Signaling Reduces Lipid Accumulation and Alleviates Postmenopausal Liver Damage.

Current atherosclerosis reports

Sex Differences in Atherosclerosis and its Clinical Complications.

Translational Lifestyle Medicine Approaches to Cardiovascular-Kidney-Metabolic Syndrome.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

Metabolic Health Differences Among Women of Age-Based Pre-, Peri-, and Post-Menopausal Stages.

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Randomized, double-blind, double-simulated, parallel controlled clinical trial of Dingkundan Oral Liquid in treating primary dysmenorrhea with cold coagulation and blood stasis].

Effects of a combined training program on lipid metabolism metabolic syndrome and physical fitness in perimenopausal Chinese female teachers.

Climacteric : the journal of the International Menopause Society

Menopausal transition and metabolic syndrome risk: insights from the Chinese PALM longitudinal cohort.

bioRxiv : the preprint server for biology

Urobiome Analysis in Interstitial Cystitis/Bladder Pain Syndrome Reveals Nuanced Differences Associated with Localized Pain.

The Canadian journal of urology

Treatment patterns for genitourinary syndrome of menopause: a TriNetX analysis.

[Menopause, hormone therapy and cardiovascular risk].

Medecine sciences : M/S

Journal of eating disorders

The broader implications of menstrual health in eating disorders: Matters Arising from Porter (2025).

Journal of menopausal medicine

Distinguishing Polycystic Ovary Syndrome Phenotype D from Functional Hypothalamic Amenorrhea with Polycystic Ovarian Morphology: Clinical and Hormonal Insights from a Pilot Retrospective Study.

Journal of menopausal medicine

Bioactive Compounds in Natural Remedies and Functional Foods for Managing Recurrent Urinary Tract Infections in Postmenopausal Women.

African journal of reproductive health

Bibliometric analysis of scientific publications on the effects of rangeland and wild plants on women's health.

Anti-aging effects of the adrenal androgens dehydroepiandrosterone and dehydroepiandrosterone sulfate: mechanisms of action and beneficial effects in older people.

Endocrine journal

The Journal of clinical endocrinology and metabolism

Insulin levels early in perimenopause inform vasomotor symptom incidence across the menopausal transition.

Sex differences in low arousal threshold in obstructive sleep apnea.

Respiratory medicine

Biology of sex differences

Hormones, heat, and health: a comprehensive review of sex-based differences in brown and beige fat biology.

Postmenopausal labial adhesion: A 5-stage classification system and clinical outcomes in a 14-patient series.

Medicina (Kaunas, Lithuania)

Topical Spermidine Hyaluronate (Spd-HA) in Vulvovaginal Atrophy: A Preliminary Study.

Medicina (Kaunas, Lithuania)

Feasibility of Multimodal Energy-Based Therapy for Pelvic Floor Disorders.

European journal of endocrinology

Integrating obesity management into menopause care recommendations comments on the 2025 European Society of Endocrinology clinical practice guideline for evaluation and management of menopause and the perimenopause.

Prevalence of hysterectomy in urban China and associations between metabolic disorders and hysterectomy: a multicenter population-based study involving over 9 million women.

BMC medicine

The Effects of Health Literacy, Social Support, and Health-Promoting Behaviors on Metabolic Syndrome Among Middle-Aged and Older Women Living in Rural Areas of Republic of Korea.

Clinical, Biochemical, and Psychological Predictors of Metabolic Syndrome in Climacteric Women.

Metabolic obesity phenotypes and breast cancer risk before and after menopause: A nationwide cohort study in South Korea.

Cancer

Human reproduction update

The human ovarian reserve: the narrative and the science.

European journal of obstetrics, gynecology, and reproductive biology

Non-hormonal vaginal gel improves vaginal and sexual health in menopausal women: results from a 6-month prospective study.

Journal of affective disorders

Associations between depressive trajectories and progression to type 2 diabetes mellitus in postmenopausal women with prediabetes: Findings from a national ten-year follow-up study.

Sex-Specific Impact of Metabolic Syndrome on Brain Structures Vulnerable to Alzheimer's Disease: A Cross-Sectional Study in a Brazilian Cohort.

Brain sciences

Climacteric : the journal of the International Menopause Society

International Menopause Society (IMS) recommendations and key messages on women's midlife health and menopause.

Management of Genitourinary Syndrome of Menopause in Korean Breast Cancer Survivors by Fractional CO₂ Laser Treatment.

Yonsei medical journal

Duhuo Jisheng Decoction mitigates postmenopausal rheumatoid arthritis by suppressing eEF2K-mediated cellular senescence.

Pharmacological research

Journal of minimally invasive gynecology

Strategies for Treating Sexual Health Concerns After Breast and Gynecologic Cancer.

Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia

Randomized clinical trial of vaginal microbiota in menopausal genitourinary syndrome using radiofrequency and topical estriol.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Hormone replacement therapy in gynecologic cancer: oncologic safety and alternative therapies.

The Kaohsiung journal of medical sciences

Risk Factors Associated With the Number of Symptoms and Distress Caused by Genitourinary Syndrome of Menopause in Taiwanese Women.

Underdiagnosed and overmedicated: Investigating the management of urinary tract infection and vaginal estrogen use in a large cohort of postmenopausal women.

Climacteric : the journal of the International Menopause Society

Safety and performance of photobiomodulation delivered by vaginal probe in patients with genitourinary syndrome of menopause.

Prevalence of metabolic syndrome among Iranian postmenopausal females: A systematic review and meta-analysis.

PloS one

Vaginal Estrogen Utilization Among Medicare Beneficiaries With Genitourinary Syndrome of Menopause.

JAMA network open

Limosilactobacillus reuteri NCU-37 alleviates leuprorelin-induced perimenopausal syndrome in infertile women by modulating the gut microbiota: a randomized controlled trial.

Food & function

Journal of women's health (2002)

Weight Management Through a Woman's Life Stages: A Practical Evidence-Based Guide.

The Journal of clinical endocrinology and metabolism

Longitudinal study of plasma metabolites during menopause and their associations with later onset of metabolic syndrome.

Journal of the American Geriatrics Society

FDA Boxed Warning Removal on Menopause Hormone Therapy: What Geriatricians Should Know.

Climacteric : the journal of the International Menopause Society

Chai-shen powder treated perimenopausal syndrome through the PI3K-Akt/cAMP signaling pathway: integrated clinical analysis, network pharmacology, microRNA and animal experiment.

When Should We Biopsy? A Risk Factor-Based Predictive Model for EIN and Endometrial Cancer.

Cancers

Association between BMI trajectories and metabolic syndrome in postmenopausal women: a cross-sectional study from NHANES 1999-2018.

BMC public health

Transitions in metabolic syndrome clustering patterns before and after menopause: a latent transition analysis in Korean women.

The journal of sexual medicine

The effect of inflammation on sexual desire and sexual function in pre- and post-menopausal women is moderated by sexual violence history.

International urogynecology journal

The Vaginal Microbiome and Recurrent and Chronic Urinary Tract Infection.

Narrative Review of Clinical Indices and Imaging Tools, With a Proposal for an Integrative Grading Scale for Vulvovaginal Aging.

Novel PNPLA6 Variants: Hypogonadotropic Hypogonadism, Pituitary Hypoplasia, Anosmia, and Cerebellar Atrophy in Siblings.

JCEM case reports

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Impact of vaginal estradiol on the genitourinary syndrome of menopause, vaginal microbiome and mucosal immune mediators in women living with HIV.

The effect of hormone replacement therapy on musculoskeletal pain in menopausal women: A systematic review and meta-analysis.

Post reproductive health

PREVALENCE OF 25-HYDROXYCHOLECALCIFEROL DEFICIENCY AND METABOLIC SYNDROME IN CROATIAN WOMEN WITH NEWLY DIAGNOSED BREAST CANCER.

Acta clinica Croatica

Archives of endocrinology and metabolism

Synthesizing the latest guideline-based recommendations for the management of female hypogonadism.

Are Hormones a risk or an opportunity? Strategies for managing women predisposed to gynecological cancers.

The effect of age on the clinical presentation and treatment of women with psychosis: secondary analysis of the IMPaCT Randomised Clinical Trial.

BJPsych open

Sea urchin bioactive compounds: emerging interventions for age-related diseases.

Ageing research reviews

Frontiers in reproductive health

Precision pharmacology in menopause: advances, challenges, and future innovations for personalized management.

Development and validation of an integrated preclinical model mimicking cardiometabolic risk in postmenopausal female rats.

Genitourinary syndrome of menopause induced by breast cancer treatments: a randomised clinical trial protocol comparing multimodal pelvic floor physiotherapy and fractional CO2 laser therapy (PILME study).

BMJ open

The British journal of general practice : the journal of the Royal College of General Practitioners

Genitourinary syndrome of menopause.

International journal of molecular sciences

Menopausal Hormone Therapy-Risks, Benefits and Emerging Options: A Narrative Review.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

Menopause as a critical window for cardiovascular-kidney-metabolic syndrome prevention: a call for integrated women's health approaches.

Neurourology and urodynamics

Is There Evidence of Diagnostic and Treatment Gaps for LUTS in Post-Menopausal Women With Genitourinary Syndrome of the Menopause? ICI-RS 2025.

A pilot study of vaginal nerve fiber and blood vessel density in postmenopausal women with genitourinary syndrome of menopause.

Musculoskeletal disorders following hysterectomy with ovarian conservation: a population-based cohort study.

Citri Reticulatae Pericarpium improves obesity in OVX mice by regulating the gut microbiota and suppressing appetite.

Food & function

Reproductive biology and endocrinology : RB&E

Exploring the association between polycystic ovary syndrome and female sexual dysfunction: a cross-sectional study.

World journal of psychiatry

From physiology to psychology: An integrative review of menopausal syndrome.

bioRxiv : the preprint server for biology

Vaginal epithelial estrogen receptor α coordinates glycogen deposition, microbial stability, and pH regulation in mice.

The Journal of nutritional biochemistry

Coenzyme Q10 ameliorates obesity by promoting white adipose tissue browning and preserving mitochondrial dynamics in ovariectomized rats fed a high-fat diet.

Aesthetic plastic surgery

Regenerative Effect of Vaginal Injections of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Ovariectomized Rats.

International urogynecology journal

Adaptation of the Genitourinary Syndrome of Menopause Symptoms and Vaginal Treatments Acceptability Questionnaire Into Turkish.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Investigating biochemical markers of Acupuncture's effectiveness in managing climacteric syndrome in breast cancer patients: the FLAIR study.

Frontiers in reproductive health

The evolution of the global disease burden of polycystic ovary syndrome and the role of regional heterogeneity in high body mass index exposure: a spatiotemporal analysis based on the global burden of disease 2021.

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

[Case of head-facial herpes zoster in perimenopausal women using Zheng's cold reducing acupuncture as primary treatment].

Complementary therapies in medicine

Impact of a yoga intervention over 6, 12, and 24 months in sedentary climacteric women with metabolic syndrome.

Gynecologic Cancers: Endometrial Cancer.

FP essentials

Association between relative handgrip strength and metabolic syndrome in Korean postmenopausal women by time since menopause.

Diabetology & metabolic syndrome

The association between metabolic syndrome and incidence of endometrial cancer: a meta-analysis.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Laser and radiofrequency for treating genitourinary syndrome of menopause in breast cancer survivors: A systematic review of randomized controlled trial.

A case of congenital long QT syndrome and medically induced menopause.

Post reproductive health

HRT-induced primary headache associated with sexual activity: A case report.

Post reproductive health

Involuntary Urine Loss in Menopause-A Narrative Review.

International journal of molecular sciences

Ceramide as a Biomarker for HFpEF in Women: Menopause, Aging, and Pregnancy.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

More than just "vaginal dryness": sexual dysfunction correlates with genitourinary anatomy changes in female cancer survivors.

Women's knowledge, attitudes, and practices regarding perimenopausal syndrome in China.

BMC public health

Expert review of endocrinology & metabolism

Management of sexual dysfunction in menopause: an update on evidence-based strategies.

TREM2 expressing macrophages are not associated with prognostic markers or metabolic syndrome in early stage ER positive breast cancer.

Effect of Danlu capsules for the treatment of breast hyperplasia with mastalgia: a multicenter, double-blind, randomized controlled trial protocol.

Frontiers in medicine

Association between serum uric acid levels and primary aldosteronism.

BMC nephrology

Diabetes, obesity & metabolism

Association between metabolic syndrome and risk of cardiovascular disease among postmenopausal women: A cohort study.

Clinical, Metabolic, and Sonographic Predictors of Endometrial Carcinoma Among Women Presenting With Postmenopausal Bleeding: A Prospective Observational Study From a Tertiary Care Center in South India.

Association between central adiposity and cognitive domain function in recently postmenopausal women: an analysis from the KEEPS-Cog substudy of the Kronos Early Estrogen Preventive Study.

American journal of obstetrics and gynecology

Salpingectomy in individuals at high risk for tubo-ovarian cancer: consensus and precaution.

Climacteric : the journal of the International Menopause Society

Healthy aging in midlife and menopausal transition in Asia: nutrient synergy with dietary supplements.

Effect of kisspeptin, neurokinin, and dynorphin neurons on regulation of reproduction.

Ceska gynekologie

The journal of sexual medicine

Platelet-rich plasma in the management of vulvovaginal disorders: a systematic review.

Clinics (Sao Paulo, Brazil)

Efficacy of acupuncture as an adjunctive therapy for perimenopausal insomnia: A systematic review and meta-analysis of randomized controlled trials.

Clinical practice perspectives on adipose-derived stem cells and platelet-rich plasma for female infertility treatments.

Future science OA

Gynecologic oncology reports

Unmet needs after prevention: a model for managing premature surgical menopause post-risk-reducing bilateral salpingo-oophorectomy.

International journal of molecular sciences

Estrogenic Effect of Probiotics on Anxiety and Depression: A Narrative Review.

Cardiovascular drugs and therapy

Metabolic Syndrome and Breast Cancer Risk: an Age-Dependent Paradox?

Archives of women's mental health

Multimodal large language models for women's reproductive mental health.

Integrative medicine research

Chinese herbal medicine Ding Kun Dan for menopausal syndrome: A systematic review and meta-analysis of randomized controlled trials.

Lasers in medical science

Effect of vaginal laser therapy for gynecologic patients on vaginal microbiota: a prospective cohort study.

Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes

Pelvic Puzzles: Imaging Non-Traumatic Emergencies of the Female Pelvis: A Comprehensive Review.

Genitourinary syndrome of menopause in Chinese-speaking sex workers attending an urban Australian sexual health clinic: a quality improvement project.

Sexual health

Rheumatology (Oxford, England)

Hormonal risk factors and androgen and glucocorticoid dysregulation in Sjogren's disease and non-Sjogren's sicca.

Current opinion in HIV and AIDS

Geriatric syndromes in women living with HIV.

Climacteric : the journal of the International Menopause Society

Osteo-sarcopenic obesity in midlife and older women: a current worldwide public health challenge.

Physiology (Bethesda, Md.)

Reproductive Fitness and the Links to Chronic Disease and Systemic Aging.

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