Impact of long-term nitrogen scavenger therapy on clinical outcome in individuals with urea cycle disorders.

ODC1 restricts meningeal B cell age-associated-like phenotype and function in multiple sclerosis: A human and experimental study.

Integrated Genome-wide Association and Single-cell Transcriptomic Analysis Identifies OAT as Therapeutic Targets for Periodontitis.

ODC1 Polyamine Metabolism Drives Prostate Cancer via AKT and Splicing.

Pediatric liver transplantation for inherited metabolic disease-Current challenges.

[Hepatic encephalopathy from cholangitis in a young patient with ornithine transcarbamylase mutation].

Hyperammonemia-Associated Stroke-Like Episodes and Acute Liver Failure in an 11-Month-Old Infant With Probable Ornithine Transcarbamylase Deficiency: Diagnostic and Therapeutic Challenges in a Resource-Limited Setting.

Polyamine metabolic enzyme SAT1 remodels the neuronal transcriptome and rescues α-synuclein toxicity in Drosophila.

Serum amino acid levels are associated with brain hypometabolism in patients across the Alzheimer's disease continuum.

Lower serum threonine and glutamine levels could be a predictor for multiple sclerosis in pregnancy.

A Complex Case of Ornithine Transcarbamylase Deficiency in a Patient With Severe Comorbid Conditions.

Unraveling the role of polyamine metabolism in postoperative delirium: insights into biochemical mechanisms and biomarker potential.

Maternal Toxoplasma gondii Infection Perturbs Foetal and Maternal Foetal Interface Metabolism, Exposing the Foetus to Kynurenine.

Akkermansia muciniphila reduces neuroinflammation and Aβ deposition via tryptophan metabolism in the APP/PS1 mouse model of Alzheimer's disease.

Development and validation of a robust UPLC-MS/MS method for the analysis of polyamines in cells, biofluids and tissues.

Gyrate atrophy of the choroid and retina: a tertiary center experience.

HLA-B27-associated gut microbiota and amino acid perturbations promote ankylosing spondylitis through M1 macrophage activation.

Infarction or Metabolic Breakdown? Longitudinally Extensive Diffusion-Restricted Lesions from the Medulla Oblongata to the Lumbar Spinal Cord.

Can ammonia scavenging treat MASLD? Evaluating the evidence for L-ornithine L-aspartate-A systematic review.

[Plasma metabolites mediates the causal effect of inflammatory proteins on Alzheimer's disease: a Mendelian randomization study].

Single-cell analysis identifies ATC-like cells driving progression in relapsed follicular thyroid carcinoma.

Biocontrol efficacy and mechanism of Bacillus subtilis PL5 against root rot of sweet potato: Insights into antifungal activity and metabolite function.

Analysis of genetic mutation distribution and metabolic characteristics in patients with primary carnitine deficiency from the Ganzhou area, China.

Phosphate binders suppress glutaminase activity for treatment of cirrhosis and hepatic encephalopathy murine models.

The antimycobacterial and healing effect of sorafenib through pro-apoptotic and immunomodulatory activities.

Biochemical, Clinical, and Functional Characterization of a Rare c.-106C>A Promoter Region Variant in Late-Onset Ornithine Transcarbamylase Deficiency: A Multifamily Case Series.

Rapid, non-invasive diagnosis of tuberculosis using desorption separation ionization mass spectrometry (DSI-MS) and urinary carbonyl metabolite fingerprints.

Synthesis-driven reverse metabolomics reveals 3-hydroxy N-acyl amides as gut microbial molecules.

Navigating the complexity of managing coexisting inborn errors of metabolism and gender incongruence.

A Mysterious Case of Recurrent Confusion: An Unusual Presentation of Congenital Intrahepatic Portosystemic Shunt.

Urea cycle modulation by combined SGLT2 inhibitors and metformin.

Radiation therapy in a ductal carcinoma in situ patient with ornithine transcarbamylase deficiency: a case report.

Polyamine pathway in neurological disorders: Potential therapeutic implications based on current evidences.

Advances in understanding, diagnosing, and treating hepatic encephalopathy: from epidemiology to emerging therapies.

The dysbiosis of intestinal microbiota associated with isolated tricuspid valve regurgitation.

First exposure to second-generation antipsychotics alters gut microbiota and metabolic profiles in patients with glucose-lipid metabolism disorders.

Ornithine lipids from Akkermansia muciniphila are dynamically modulated in colitis and shape macrophage inflammatory responses.

Changes in the microbiota following allogeneic hematopoietic stem cell transplantation: A potential bioguide for clinical outcome?

Combined inhibition of polyamine biosynthesis and uptake blocks Candida albicans virulence.

GAMT Deficiency: Clinical Presentation, Treatment, Diagnosis, Animal Models, Preclinical and Clinical Developments.

Genetic insights into the causal role of metabolic, immune, and microbial factors in migraine.

Cerebrospinal Fluid Neurotransmitters, Pterins, Folates and Amino Acids in Paediatric Onset Epilepsies: A Tertiary Centre Retrospective Cohort Study.

Gut microbiota L-ornithine promotes resistance to obesity through metabolites mediated immunosuppressive macrophages.

Lysosomal acidity and cathepsin L activate eosinophils via ARG1-mediated arginine metabolism in allergic airway inflammation.

Amino acid decarboxylation preserves Salmonella fitness during phagocyte-derived oxidative stress.

Altered Arginine Metabolism in Children Undergoing Fontan Palliation: A Prospective Cohort Study.

Serum analysis of type 2 diabetes mellitus patients with low, moderate, and high risk of diabetic kidney disease using LC-MS metabolomics approach.

Realgar-Induced CNS Toxicity: Exploring OTC-Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver-Brain Axis.

Androgen Receptor Drives Polyamine Synthesis, Creating a Vulnerability for Prostate Cancer.

Biological Validation of the PSC-MCAT: Analyzing Dental Plaque Microbiota Across Caries Risk Levels in Preschoolers.

[Hyperammonemia and metabolic-associated fatty liver disease: a complex relationship].

Hyperammonemia in Inherited Metabolic Diseases: A Case Report.

Brain fog and protein logs: unravelling encephalopathy in lysinuric protein intolerance with rare mutation and expanded phenotypic spectrum.

Infantile Spasms in Inborn Errors of Metabolism: Diagnostic and Therapeutic Considerations.

Early continuous blood purification and timely liver transplantation in a neonatal-onset ornithine transcarbamylase deficiency: a case report.

Fatal ornithine transcarbamylase deficiency presentation postresection of fourth ventricle ependymoma: illustrative case.

Integrated gut microbiota and metabolomic profiling reveals key associations between amino acid levels and gut microbial composition in patients with obesity.

Nephrotic Syndrome Induced by Tiopronin in a Male Patient with Cystinuria.

Metabolomics Profiling of Kidney, Spleen, Lung, and Liver Tissues in a Mouse Model of Sepsis.

In vitro derivation of midbrain dopaminergic neurons from porcine embryonic stem cells in multi-dimensional conditions.

Severe Neurological Sequelae and Radiological Findings in a Lost-to-Follow-Up Case of Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome.

Serum L-ornithine-derived polyamines as indicators of Parkinson disease progression.

Analysis of the time-course change of acute-phase energy metabolism in critically ill patients using untargeted metabolomics.

Metabolomics approaches for the early detection and therapeutics: type 2 diabetes-induced diabetic kidney disease-a systematic review and meta-analysis.

TET1 modulates trophoblast function by regulation of ODC1 in preeclampsia.

Investigation of N-desmethyl-acetamiprid-induced neurotransmitter disturbances in cerebrospinal fluid from leukemia patients.

Loss of arginase 2 disrupts striatum-specific polyamine homeostasis.

Metabolomic profiling of Burkholderia thailandensis infection of airway epithelial cells provides insights into potential therapeutic targets.

Nitrogen Scavengers: History, Clinical Considerations and Future Prospects.

L-ornithine liposomal nanoparticles as competitive inhibitor against Δ1-pyrroline-5-carboxylate dehydrogenase: Kinetic perspective hepatic encephalopathy therapy.

Preclinical Evaluation of the Efficacy of α-Difluoromethylornithine and Sulindac Against SARS-CoV-2 Infection.

Liver transplantation can prevent the progression of neurological damage in hyperornithinemia-hyperammonemia-homocitrullinuria syndrome and maintain long-term metabolic stability - The largest single-center experience.

Multi-omics insights into the molecular basis of powdery mildew resistance and root metabolic variation in Astragalus membranaceus var. mongholicus.

HIVEP1 aggravates NASH by reprogramming polyamine metabolism in TH17 cells.

Development of patient-centric conceptual frameworks for symptoms and impacts of ornithine transcarbamylase deficiency (OTCD).

κ-Opioid receptor activation suppresses triple-negative breast cancer progression by inducing urea cycle dysfunction and mitochondrial damage in vitro and in mice.

Mendelian randomization suggests a causal relationship between cerebrospinal fluid metabolites and intracranial aneurysms.

Liver transplantation in late-onset ornithine transcarbamylase deficiency with acute liver failure: A case report.

Yiai Fuzheng decoction inhibits triple-negative breast cancer by remodeling the immune microenvironment.

Podocyte Metabolic Reprogramming and Targeted Therapy.

The Current Status of Adult Patients With Urea Cycle Disorders in Japan: From the Nation-Wide Study.

The Evolving Trend of Liver Transplantation in Metabolic Diseases: From Origins to Current Perspectives.

Quantitative analysis of serum metabolites in a rat model of Alzheimer's disease.

Developing an explainable machine learning model to predict false-negative citrin deficiency cases in newborn screening.

Disruption of P. falciparum amino acid transporter elevates intracellular proline and induces resistance to Prolyl-tRNA synthetase inhibitors.

FMO2 Promotes Angiogenesis via Regulation of N-Acetylornithine.

Monoclonal antibody-based assay to identify compounds that inhibit Nδ-(5-hydro-4-imidazolon-2-yl)ornithine (G-H1) formation.

Yigong San Extract Modulates Metabolism, Antioxidant Status, and Immune Function to Improve Health in Diarrheic Calves.

Alteration of the follicular fluid amino acid profile reveals the important roles of several amino acids in embryo quality in patients with polycystic ovary syndrome.

Reprogramming neuroblastoma by diet-enhanced polyamine depletion.

Current Treatment Modalities for Urea Cycle Disorders.

ODC1 loss upon KLF6 upregulation promotes macrophage pyroptosis and acute kidney injury in sepsis.

Identification of potential biomarkers for diabetic nephropathy via UPLC-MS/MS-based metabolomics.

Amino acid profiles, aging, and sex hormone interactions in the elderly Iranian population: a metabolomics study.

Cerebrospinal amino acid profiling in a large cohort of neuropediatric patients with epilepsy.

Phase I dose-escalation trial of AMXT 1501 dicaprate plus difluoromethylornithine: a dual-agent approach targeting immunosuppressive polyamine metabolism.

Myeloid-mesenchymal crosstalk drives ARG1-dependent profibrotic metabolism via ornithine in lung fibrosis.

Recurrent Male Neonatal Deaths in a Heterozygous X-linked Ornithine Transcarbamylase Deficiency Carrier Pregnant Woman.

[Clinical characteristics and efficacy of glyceryl phenylbutyrate treatment in 20 pediatric patients with urea cycle disorder].

Characterization of intestinal microbiota in patients with psoriasis combined with metabolic syndrome.

Metabolic, pathological, and genetic analyses of foals neonatal foals that died in Noma horses.

A Case of a Heterozygous Female Patient With Ornithine Transcarbamylase (OTC) Deficiency Successfully Treated by Liver Transplantation in Adulthood.

Clinical characteristics and long-term outcomes of 101 patients with urea cycle disorders in China.

Arginine Metabolic Disruption Impairs Hair Regeneration via ROS-Mediated Inactivation of mTOR Signaling in Androgenetic Alopecia.

Personalized Clostridioides difficile colonization risk prediction and probiotic therapy assessment in the human gut.

High-dose DFMO alters protein translation in neuroblastoma.

Antimycobacterial and immunomodulatory activities of sorafenib in a preclinical mouse model of TB infection through CD4+CD25low and CD8+CD25low effector T cells.

Divergent roles of red cell arginase in humans and mice: RBC Arg1 KO mice show preserved systemic l-arginine bioavailability and infarct size in vivo.

Targeted metabolomics analysis of 21 amino acids in serum of silicosis patients using HILIC-MS/MS.

Polyamine Depletion by D,L-α-Difluoromethylornithine Inhibits Ewing Sarcoma Metastasis by Inducing Ferroptosis.

Diagnostic challenges in ornithine transcarbamylase deficiency lacking genetic confirmation: liver biopsy versus human induced pluripotent stem cell technology.

Arginase deficiency in Mexico: Insights from the experience of a metabolic reference center.

Discovery of a Widespread Polyamine-Low-Molecular-Weight Thiol Hybrid Pathway in Clostridioides difficile.

Late-onset ornithine transcarbamylase deficiency mimicking cognitive, behavioral and gait disorders: a case report and literature review.

Asymmetric dimethylarginine and citrulline are risk factors for cardiovascular disease independently of both estimated and measured GFR.

The current social status in adult patients with urea cycle disorders in Japan.

Cl-amidine confers organ protection and improves survival in hemorrhagic shock rats via the PAD4-CitH3-NETs axis.

An Open-Label Randomized Controlled Non-Inferiority Trial of Arginine Glutamate Injection for the Treatment of Mild Hepatic Encephalopathy.

Alteration of Tear Metabolomics Profiling in Infants With Retinopathy of Prematurity.

Constraint-based modeling of bioenergetic differences between synaptic and non-synaptic components of dopaminergic neurons in Parkinson's disease.

Integrated analysis of serum metabolomics and fecal microbiome in infants with necrotizing enterocolitis.

Fecal gut microbiota and amino acids as noninvasive diagnostic biomarkers of Pediatric inflammatory bowel disease.

Perioperative care in pediatric OTC deficiency and goldenhar syndrome: a case report.

Preparation of a Brucella multiepitope fusion protein based on bioinformatics and its application in serological diagnosis of human brucellosis.

Mechanism Study on the Preventive Effect of ELITEA Compound Tea on Hyperuricemia in Rats Based on Serum Untargeted Metabolomics.

Novel Treatment Strategy for Patients With Urea Cycle Disorders: Pharmacological Chaperones Enhance Enzyme Stability and Activity in Patient-Derived Liver Disease Models.

Application of IVDr NMR spectroscopy to stratify Parkinson's disease with absolute quantitation of blood serum metabolites and lipoproteins.

Collection, preparation, and biobanking of clinical specimens for analysis in polyaminopathies.

Monitoring ODC activity and polyamines in Bachmann-Bupp syndrome patient biological samples.

Endogenous dysregulated energy and amino acid metabolism delay scaffold-guided large volume bone regeneration in a diabetic rat model with Leptin receptor deficiency.

The mitochondrial protease ClpP is a metabolic vulnerability and an immunogenic trigger against multiple myeloma.

In Vivo Antitumor Activity of Allicin in a Pediatric Neuroblastoma Patient-derived Xenograft (PDX) Mouse Model.

LACC1 Enhances Polyamine Immunometabolism in Inflammatory Macrophages to Inhibit Atherosclerosis Progression.

Urea cycle defects in adulthood: clinical presentation, diagnosis and treatment in genetically encoded hepatic metabolic disorders with a potential for encephalopathy.

Pipecolic acid: A positive regulator of systemic acquired resistance and plant immunity.

Analysis of Metabolomic Reprogramming Induced by Infection with Kaposi's Sarcoma-Associated Herpesvirus Using Untargeted Metabolomic Profiling.

Dietary advanced glycation end products may increase the incidence of allergic rhinitis depending on genetic susceptibility: a prospective cohort study.

Child Neurology: Creatine Biosynthesis Disorder in an Adolescent With Capgras Syndrome and Reduplicative Paramnesia.

Understanding the Natural History and the Effects of Current Therapeutic Strategies on Urea Cycle Disorders: Insights from the UCD Spanish Registry.

Neutrophil Extracellular Traps-Associated RNA Impedes CD4+ Treg Differentiation by TLR7-IRF7 Axis in Ankylosing Spondylitis.

Astrocytic Ornithine Decarboxylase 1 in Alzheimer's Disease.

OTC gene duplication as the possible cause of massive hyperammonaemia with a fatal prognosis.

Oleic acid regulates CD4+ T cells differentiation by targeting ODC1-mediated STAT5A phosphorylation in Vogt-Koyanagi-Harada disease.

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Multiomics approach reveals the comprehensive interactions between nutrition and children's gut microbiota, and microbial and host metabolomes.

Hepatic Encephalopathy: Current Thoughts on Pathophysiology and Management.

L-arginine dependence of breast cancer - molecular subtypes matter.

Dissecting Causal Relationships Between Immune Cells, Plasma Metabolites, and PCOS: Evidence From Mediating Mendelian Randomization Analysis.

Clinical and biochemical characteristics of patients with ornithine transcarbamylase deficiency and in silico analysis of OTC gene.

Maternal health outcomes in ornithine transcarbamylase deficiency: A comparative analysis of pregnancies in symptomatic and asymptomatic heterozygotes.

Salivary Metabolomics as a Diagnostic Tool: Distinct Metabolic Profiles Across Orofacial Pain Subtypes.

Biochemical Characterization of Disease-Associated Variants of Human Ornithine Transcarbamylase.

Hyperammonemia induces programmed liver cell death.

Multi-omics analysis of synovial tissue and fluid reveals differentially expressed proteins and metabolites in osteoarthritis.

Empagliflozin ameliorates renal and metabolic derangements in obese type 2 diabetic mice by blocking advanced glycation end product-receptor axis.

Design, Synthesis, and Biological Activity of Novel Ornithine Decarboxylase (ODC) Inhibitors.

Astrocyte dysfunction alters GABAergic communication and ammonia metabolism in the streptozotocin-induced sporadic Alzheimer's disease model.

Arginine metabolism and neurocognitive impairment in offspring of bipolar parents: a high-risk case-control study.

Jinkui Shenqi decoction targets PAD4 to restrain NETosis and ameliorates psoriasis progression.

Mechanism of calcitonin gene related peptide against acute pancreatitis in rats by modulating amino acid metabolism based on metabonomics.

Non-targeted Metabolomics Reveals the Potential Role of MFSD8 in Metabolism in Human Endothelial Cells.

Mass spectrometry-based analysis of eccrine sweat supports predictive, preventive and personalised medicine in a cohort of breast cancer patients in Austria.

Polyamine depletion limits progression of acute leukaemia.

The polyamine transporter ATP13A3 mediates difluoromethylornithine-induced polyamine uptake in neuroblastoma.

Synergistic role of gut-microbial L-ornithine in enhancing ustekinumab efficacy for Crohn's disease.

Polyamine metabolism is dysregulated in COXFA4-related mitochondrial disease.

Evaluation of serum arginine metabolic pathway markers in patients with bipolar disorder and schizophrenia.

Biochemistry, pharmacology, and in vivo function of arginases.

Blood biomarker fingerprints in a cohort of patients with CHRNE-related congenital myasthenic syndrome.

Dose-dependent M2 macrophage polarization induced by Talaromyces marneffei promotes lung cancer cell growth via arginine-ornithine-cycle activation.

Ocular Tissue-Specific Amino Acid Metabolism in Gyrate Atrophy.

Urinary metabolomics analysis of patients with renal tubular dysfunction after PCI surgery.

Blimp-1 orchestrates macrophage polarization and metabolic homeostasis via purine biosynthesis in sepsis.

The Frequencies of Different Inborn Errors of Metabolism in Adult Metabolic Centres: 10 Years Later, Another Report From the SSIEM Adult Metabolic Physicians Group.

Single centre retrospective review of plasma branched-chain amino acid levels in children with urea cycle disorders: Impact of treatment modalities and disease severity.

Ornithine decarboxylase and its role in cancer.

Amino Acid Patterns in Children with Autistic Spectrum Disorder: A Preliminary Biochemical Evaluation.

Comprehensive Metabolomic Profiling in Adults with X-Linked Hypophosphatemia: A Case-Control Study.

Attenuating hyperammonemia preserves protein synthesis and muscle mass via restoration of perturbed metabolic pathways in bile duct-ligated rats.

Polyproline-Polyornithine Diblock Copolymers with Inherent Mitochondria Tropism.

Establishment and evaluation of a method for measuring ornithine transcarbamylase activity in micro blood of neonates.

[Tandem mass spectrometry screening and genetic analysis of neonates with Urea cycle disorders].

Novel Insights Into Gyrate Atrophy of the Choroid and Retina (GACR): A Cohort Study.

Salivary microbiota dysbiosis and elevated polyamine levels contribute to the severity of periodontal disease.

Androgen receptor drives polyamine synthesis creating a vulnerability for prostate cancer.

Cross-reactivity of anti-modified protein antibodies in rheumatoid arthritis.

Host Metabolic Alterations Mediate Phyllosphere Microbes Defense upon Xanthomonas oryzae pv oryzae Infection.

Effect of menopause on circulating amino acid concentrations in women with fibromyalgia and healthy women.

The gut microbiota-produced vitamin B6 mitigates alcohol-associated liver disease by attenuating hepatic oxidative stress damage.

Metabolic Analysis of Three-Dimensional Cultured Gastrointestinal Cancer Cells Suggests that <sc>l</sc>-Arginine Inhibits Tumor Growth by Affecting the Urea Cycle.

Alterations in Mitochondrial Function in Pulmonary Vascular Diseases.

Assessment of the Relationship Between Amino Acid Status and Parkinson's Disease: A Comprehensive Review and Meta-analysis.

Metabolomic profiles of infants classified as sudden infant death syndrome: a case-control analysis.

Multimodal imaging and genetic screening in Mexican patients with Gyrate atrophy: identification of novel OAT pathogenic variants.

The role of urine metabolomics in the diagnosis and management of adult and pediatric Crohn's disease and ulcerative colitis.

Pharmacological blocking of neutrophil extracellular traps attenuates immunothrombosis and neuroinflammation in cerebral cavernous malformation.

Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome in Vietnamese Patients.

Biomarkers of Frailty in Patients with Advanced Chronic Liver Disease Undergoing a Multifactorial Intervention Consisting of Home Exercise, Branched-Chain Amino Acids, and Probiotics.

A novel de novo missense OTC mutation in an Iranian girl: a case report.

A Case of Hyperammonemia Not Attributable to Liver Disease and Treated With IV Ammonia Scavengers.