A Síndrome de Sweet (também conhecida como dermatose neutrofílica febril aguda) é caracterizada por um conjunto de sintomas que a pessoa sente, sinais visíveis no corpo e alterações encontradas em exames de tecido. Ela inclui febre, um aumento de neutrófilos (que são um tipo de glóbulo branco de defesa) no sangue, e lesões na pele que são avermelhadas, sensíveis e dolorosas ao toque (como bolinhas pequenas e elevadas, caroços e manchas maiores e planas). Além disso, há um acúmulo de células de defesa, principalmente neutrófilos maduros, espalhado pela parte de cima da derme (uma das camadas da pele).
Introdução
O que você precisa saber de cara
A Síndrome de Sweet (também conhecida como dermatose neutrofílica febril aguda) é caracterizada por um conjunto de sintomas que a pessoa sente, sinais visíveis no corpo e alterações encontradas em exames de tecido. Ela inclui febre, um aumento de neutrófilos (que são um tipo de glóbulo branco de defesa) no sangue, e lesões na pele que são avermelhadas, sensíveis e dolorosas ao toque (como bolinhas pequenas e elevadas, caroços e manchas maiores e planas). Além disso, há um acúmulo de células de defesa, principalmente neutrófilos maduros, espalhado pela parte de cima da derme (uma das camadas da pele).
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 30 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 44 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
2 genes identificados com associação a esta condição. Padrão de herança: Multigenic/multifactorial.
Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobul
CytoplasmNucleus
Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma (PubMed:10807793, PubMed:11468188, PubMed:16037825, PubMed:16785446, PubMed:17431422, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923, PubMed:26347139, PubMed:27030597, PubMed:28835462). Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinat
Cytoplasm, cytoskeletonCell projection, ruffleCell projection, lamellipodiumNucleusCytoplasmCytoplasmic vesicle, autophagosome
Familial Mediterranean fever, autosomal recessive
A hereditary periodic fever syndrome characterized by recurrent episodic fever, serosal inflammation and pain in the abdomen, chest or joints. It is frequently complicated by reactive amyloidosis, which leads to renal failure and can be prophylactically treated with colchicine.
Variantes genéticas (ClinVar)
270 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
23 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Síndrome Sweet
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
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Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
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2 ensaios clínicos encontrados, 1 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 619
Extraintestinal Cutaneous Manifestations in Inflammatory Bowel Disease Among Non-White Patients: A Retrospective Multicenter Study.
The presence of extraintestinal manifestations with cutaneous diseases in patients with inflammatory bowel disease (IBD) can pose significant complications. Though the prevalence of IBD has been increasing in racial and ethnic minority groups, most literature has characterized several cutaneous manifestations (CM) of IBD in patients of white skin, with a lack of studies describing these complications in patients with other skin tones. Our study aimed to determine the rates of various CM of IBD in skin of color using a health care database to identify white and non-white patients with a diagnosis of IBD who were prescribed at least one IBD-specific medication or advanced therapy. Of the total IBD patients, after propensity score matching there were 35,624 patients identified in both the white and non-white cohorts. Among non-white patients, there was a >2-fold odds of developing hidradenitis suppurativa and increased odds of vitiligo. Psoriasis, herpes zoster, and leukocytoclastic vasculitis exhibited a decreased association in non-white patients. There was no difference in erythema nodosum, pyoderma gangrenosum, oral aphthae, Sweet syndrome, and acquired epidermolysis bullosa. With the rise of IBD in non-white populations, the representation of CM of IBD in this population is significantly limited, underrecognized, and thus undertreated. Our results reveal increased prevalence of several CM in the non-white IBD patient population. Recognition of CM in non-white patients with IBD can enhance quality of life and reduce morbidity among this population.
Clinicopathologic Spectrum of Dermatological Diseases in Patients with Acute Myeloid Leukemia (AML): A Retrospective Study in AML Patients with Cutaneous Manifestations.
Leukemia is one of the most common hematological malignancies. Cutaneous manifestations of leukemias consist of two groups: specific and non-specific. While the drug reactions, opportunistic infections due to myelosuppression are non-specific skin findings of leukemias, leukemia cutis is a specific sign of cutaneous involvement. In this retrospective study, we included patients over the age of 18 who were diagnosed with acute myeloid leukemia (AML) and underwent histopathological examination due to dermatological complaints. A total of 21 patients were included. Histopathological examination results were consistent with myeloid sarcoma, erythema nodosum, cutaneous drug eruption, necrosis due to vascular damage, cutaneous vasculitis, graft versus host disease, Sweet syndrome and viral infection. Dermatological examination plays an important role in AML patients. Skin biopsy and immunohistochemical examination should be performed to make early diagnosis of skin metastasis of leukemias and paraneoplastic syndromes to reduce the mortality and morbidity in AML patients.
Myeloid dermatosis with features of sweet syndrome and leukemia cutis: a case report.
Occult hematologic malignancies can initially present with cutaneous manifestations. We describe a 53-year-old woman with chronic hepatitis C and intravenous drug use presenting with a painful, progressive leg rash and worsening bicytopenias. A skin punch biopsy revealed neutrophilic dermatosis morphologically compatible with Sweet syndrome (SS), along with rare CD117+/CD34 − blastoid cells. Subsequent bone marrow studies revealed acute myeloid leukemia with mutated NPM1. This case highlights the diagnostic challenge of distinguishing SS from leukemia cutis (LC) when skin biopsies demonstrate mixed neutrophilic with rare blastoid cells. LC represents cutaneous infiltration of leukemic blasts, whereas SS represents a non-neoplastic, cytokine-driven process. Prompt immunophenotypic evaluation and genomic testing of myeloid dermatoses, particularly those with blastoid cells, can be critical in distinguishing SS from LC to provide significant insight on prognosis and therapeutic options. This case highlights the clinical and histopathologic spectrum of myeloid dermatoses and further emphasizes the relevance of skin biopsies in the diagnosis of cutaneous involvement by hematologic malignancies, such as myeloid neoplasms.
Wrong Place at the Right Height: Scalp Orf in a Toddler With Dense Dermal Neutrophilic Infiltrate Mimicking Sweet Syndrome.
We report a case of a 3-year-old male who presented with fever, posterior cervical lymphadenopathy, and a tender vesiculobullous lesion on the scalp following contact with goats 2 weeks prior. Histopathology revealed epidermal necrosis, massive papillary dermal edema, brisk mixed inflammation with abundant neutrophils, and inclusion bodies in the epidermis. These findings led to a diagnosis of orf virus infection, otherwise known as ecthyma contagiosum, which is a parapox virus acquired from goats and sheep. An abundance of neutrophils is not a feature classically thought to be associated with orf virus. Additionally, orf typically affects the hands following direct contact with infected animals; the scalp is an unusual site of infection. We suspect infection occurred as this child's scalp when standing was roughly the same height as a goat's mouth, and goats have a predilection to chew at hair. Unfortunately, despite extensive attempts, we were unable to find any laboratory that offers molecular testing for orf on formalin-fixed paraffin-embedded tissue samples. Because of the lack of readily available molecular testing for this infection, we seek to highlight the importance of considering orf in the differential diagnosis of vesicular lesions and obtaining animal exposure history to aid in this diagnosis.
From Aortitis to Sweet's: The Immune Spectrum of G-CSF Adverse Events.
Granulocyte colony-stimulating factor (G-CSF) and its PEGylated formulation (pegfilgrastim) are indispensable for preventing chemotherapy-induced neutropenia and for stem-cell mobilization. Beyond hematopoiesis, G-CSF modulates innate/adaptive immunity and may precipitate immune-mediated events in susceptible hosts. Clinical signals span large-vessel vasculitis/aortitis and non-vascular neutrophil-dominant phenotypes, yet timing, spectrum, and management remain variably characterized. To identify and synthesize primary clinical reports of autoimmune/rheumatic disease triggered or exacerbated by exogenous G-CSF (filgrastim or pegfilgrastim), describing phenotypes, latency, management, outcomes, and implications for practice. We performed a narrative review of primary clinical studies, including observational cohorts and case reports or short case series, identified through targeted searches of PubMed/MEDLINE, Scopus, and Embase, complemented by investigator-curated references. Eligible reports described autoimmune, inflammatory, or rheumatic manifestations occurring after exposure to exogenous G-CSF. Predefined phenotypes included large-vessel vasculitis/aortitis; neutrophilic dermatoses (e.g., Sweet's syndrome, neutrophilic dermatosis of the dorsal hands); cutaneous small-vessel vasculitis; inflammatory or crystal arthritis (e.g., calcium pyrophosphate deposition disease); pulmonary inflammatory injury (e.g., diffuse alveolar hemorrhage); and clear flares of established autoimmune disease. Narrative or mechanistic reviews and trials of GM-CSF pathway blockade were excluded from qualitative synthesis. Twenty-four studies met inclusion criteria: two observational cohorts and twenty-two single-patient reports/short series. Cohorts quantified a low but reproducible burden of pegfilgrastim-associated aortitis, with stereotyped involvement of the aortic arch/proximal branches and typical latency of 7-15 days. Case-level data confirmed marked elevation of acute phase reactants, usually negative autoantibodies, favorable outcomes after G-CSF withdrawal with or without short glucocorticoid courses, and recurrence/migration on re-exposure. Non-vascular events clustered earlier (2-7 days) and included biopsy-proven Sweet's/NDDH, leukocytoclastic vasculitis, CPPD flares, and rare diffuse alveolar hemorrhage; granulomatous dermatitis and perioperative pyoderma gangrenosum were also observed. Re-exposure information suggested phenotype-specific risk: recurrent CPPD with pegfilgrastim was mitigated by switching to short-acting filgrastim; selected limited aortitis resolved without steroids; refractory aortitis responded to IL-6 blockade, enabling uninterrupted chemotherapy. Exogenous G-CSF can precipitate a coherent spectrum of immune-mediated toxicity with distinct, clinically actionable timing windows: vascular events peak 7-15 days after pegfilgrastim, whereas cutaneous, articular, and pulmonary manifestations arise within 2-7 days. Recognition hinges on temporal linkage, imaging/histology, and exclusion of mimics. Management is phenotype-aware-drug withdrawal ± short glucocorticoids, formulation switching for CPPD, and targeted IL-6 blockade in selected refractory aortitis-allowing preservation of hematologic benefits while minimizing immune toxicity. Prospective surveillance and structured re-exposure studies (including formulation tailoring) are priorities to move from signal detection to prevention.
Publicações recentes
A Rare Hybrid Presentation: Coexistence of Necrotizing and Histiocytoid Variants of Sweet Syndrome (SS) in a Patient With Acute Myeloid Leukemia (AML).
Subcutaneous Sweet Syndrome as an uncommon mucocutaneous manifestation in systemic lupus erythematosus: a case report and literature review.
🥉 Relato de casoVaping and Orthopaedic Surgery: A scoping review of the literature.
Myeloid dermatosis with features of sweet syndrome and leukemia cutis: a case report.
📖 RevisãoSweet Syndrome in a Patient With Adult-Onset Immunodeficiency Due to Anti-Interferon-Gamma Autoantibodies: A Case Report and Brief Review of the Literature.
📚 EuropePMC688 artigos no totalmostrando 196
Myeloid dermatosis with features of sweet syndrome and leukemia cutis: a case report.
Annals of hematologySweet Syndrome in a Patient With Adult-Onset Immunodeficiency Due to Anti-Interferon-Gamma Autoantibodies: A Case Report and Brief Review of the Literature.
The American Journal of dermatopathologyAcute bullous iododerma with cryptococcoid neutrophilic dermatosis: A case series.
JAAD case reportsWrong Place at the Right Height: Scalp Orf in a Toddler With Dense Dermal Neutrophilic Infiltrate Mimicking Sweet Syndrome.
Journal of cutaneous pathologyMonoclonal gammopathies of cutaneous significance: A nomenclature and pathophysiology-based classification.
Journal of the American Academy of DermatologyFrom Aortitis to Sweet's: The Immune Spectrum of G-CSF Adverse Events.
Seminars in arthritis and rheumatismBeyond Sweet Syndrome: Untangling the Threads of Histiocytoid Sweet Syndrome and Cutaneous Myeloid Neoplasia.
Surgical pathology clinicsSweet syndrome presenting with pustular lesions and pulmonary involvement: a case report.
European journal of dermatology : EJDThe Case | Rash, eosinophilia, adrenal mass, and acute kidney injury in a febrile patient.
Kidney internationalExtraintestinal Cutaneous Manifestations in Inflammatory Bowel Disease Among Non-White Patients: A Retrospective Multicenter Study.
Journal of clinical gastroenterologyPeriocular necrotizing sweet syndrome - a case series and review of literature.
Orbit (Amsterdam, Netherlands)Clinicopathologic Spectrum of Dermatological Diseases in Patients with Acute Myeloid Leukemia (AML): A Retrospective Study in AML Patients with Cutaneous Manifestations.
Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood TransfusionPeriorbital Necrotizing Sweet Syndrome: A Case Report and Literature Review.
Ophthalmic plastic and reconstructive surgeryConcurrent paraneoplastic dermatomyositis and Sweet syndrome.
JAAD case reportsA Rare Case of Metastatic Urethral Squamous Cell Carcinoma Presenting with Paraneoplastic Sweet Syndrome and Treated with Pembrolizumab.
Current oncology (Toronto, Ont.)Cryptococcid Sweet Syndrome in the Setting of Hydralazine-Induced ANCA Vasculitis: A Case Report.
Journal of cutaneous pathologyA Case of Cutaneous Dirt-Adherent-Like Sweet Syndrome in Pregnancy.
International journal of women's healthDisseminated Talaromyces marneffei infection mimicking tuberculosis in an HIV-negative adult with anti-IFN-γ autoantibodies: a case report.
BMC infectious diseasesA Case of Sweet Syndrome Complicating Ulcerative Colitis Treated With Upadacitinib.
ACG case reports journalRifampicin-Associated Sweet Syndrome: An Uncommon Adverse Event of Anti-Tuberculosis Therapy.
Respirology case reportsCutting-edge multiomic approaches shed light on the interleukin-36 axis in Sweet syndrome.
The British journal of dermatologyUpper Respiratory Tract Infection Leading to a New Diagnosis of Sweet Syndrome and Monoclonal Gammopathy of Unknown Significance.
HCA healthcare journal of medicineA case of giant cellulitis-like Sweet syndrome and review.
JAAD case reportsTNF Inhibitor Therapy in Corticosteroid-Resistant or -Dependent Pediatric Neutrophilic Dermatosis.
Pediatric dermatologyInterleukin-36 as the central amplifier of neutrophilic inflammation: lessons from spatiotemporal transcriptomics in Sweet syndrome.
The British journal of dermatologyAcute febrile neutrophilic dermatosis in the setting of pembrolizumab in a patient with nonsmall cell lung cancer.
Dermatology online journalSweet syndrome successfully treated with upadacitinib.
JAAD case reportsCutaneous Manifestations and Dermatologic Adverse Events in IBD: A Clinical Update.
Inflammatory bowel diseasesSpatiotemporal transcriptomics deciphered neutrophil-activated interleukin-36 as driver and effective therapeutic target in Sweet syndrome.
The British journal of dermatologyHistiocytoid Sweet Syndrome - A systematic literature review of the clinical and histological characteristics and treatment outcomes.
Journal of the European Academy of Dermatology and Venereology : JEADVKeratinocyte-neutrophil interactions revealed as targetable drivers of sustained inflammation in Sweet syndrome.
The Journal of clinical investigationLeukoplakia: An uncommon presentation of acute febrile neutrophilic dermatosis (Sweet syndrome).
JAAD case reportsCryptococcoid Sweet syndrome or halogenoderma? Highlighting the crucial need for serum iodine testing.
JAAD case reportsDrug-induced Sweet's syndrome: pharmacovigilance insights from FAERS with a cross-database consistency assessment in VigiBase via LASSO and multivariable logistic regression.
Frontiers in immunologyHistiocytoid Sweet syndrome-like presentation of mature plasmacytoid dendritic cell proliferation.
Dermatology online journalA Case Report of Sweet Syndrome and Hemorrhagic Bullae Associated With Acute Myeloid Leukemia With Myelodysplasia-Related Changes.
CureusRecurrent Annular Erythema as an Initial Presentation of Pediatric Histiocytoid Sweet Syndrome Associated With Myelodysplastic Syndrome: A Case Report.
The Journal of dermatologySweet Syndrome-like Dermatosis as a Precursor to Overlapping Hematologic Malignancies: A Case Report and Review.
Journal of clinical medicineEpidemiology, Clinical Data, and Management of Aseptic Abscess Syndrome: Review of Published Cases Outside France.
Epidemiologia (Basel, Switzerland)Bleomycin-induced Sweet's syndrome.
Indian journal of pharmacologySAA1/FPR2 signaling between keratinocytes and neutrophils sustains chronic inflammation in Sweet syndrome.
The Journal of clinical investigationSweet Syndrome in Patients With Hidradenitis Suppurativa: A Population Study in the TriNetX Research Database.
International journal of dermatologyCardiovascular involvement in Sweet's syndrome: A practical review.
Caspian journal of internal medicineComplex Interplay Between Sweet Syndrome and Therapy-Related Myelodysplastic Syndrome After B-Cell Lymphoma Treatment: A Case Report.
The American journal of case reportsNontuberculous scrofuloderma with sweet syndrome leading to anti-interferon-γ autoantibody-associated adult-onset immunodeficiency: A case report.
JAAD case reportsCryptococcoid Sweet Syndrome Following Gastrointestinal Neuroendocrine Tumor Removal: A Case Report.
CureusSubcutaneous panniculitis-like T-cell lymphoma in pregnancy.
BMJ case reportsSweet Syndrome and Valley Fever: A Case Report.
Journal of the American College of Emergency Physicians openAn Acute Onset Sweet Syndrome After First Vedolizumab Dose in Crohn's Disease.
Inflammatory bowel diseasesUnveiling the bridge between neutrophilic and autoinflammatory spectrum. Good response to old but gold colchicine in a complex clinical association of Sweet Syndrome with psoriasis and hidradenitis suppurativa under treatment with ixekizumab.
Italian journal of dermatology and venereologyPositionally distinct interferon-stimulated dermal immune-acting fibroblasts promote neutrophil recruitment in Sweet syndrome.
The Journal of allergy and clinical immunologyDiffuse necrotizing pneumonia, cavitations and hemoptysis: A case of sweet syndrome.
Respiratory medicine case reportsSweet's syndrome as a presenting symptom of granulomatosis with polyangiitis.
BMJ case reportsRickettsia parkeri Rickettsiosis Resembling Sweet Syndrome: A Differential Diagnosis for Critical Discussion.
Infectious disease reportsFirst Description of Simultaneous Sweet Syndrome and Tracheal Stenosis as Extraintestinal Manifestations in a Patient With Highly Active Ulcerative Colitis.
ACG case reports journalBilateral Scleritis and Neutrophilic Dermatosis With Cytogenetic Chromosomal Aberrancy Related to Pyoderma Gangrenosum: A Case Report of a 20-Year Follow-Up.
CureusTigecycline Induced Sweet Syndrome in a Patient on Maintenance Hemodialysis.
Hemodialysis international. International Symposium on Home HemodialysisNeutrophilic Urticarial Dermatosis: A Window into Systemic Inflammation and Autoimmune Disorders.
Clinical reviews in allergy & immunologyAn Atypical Presentation of VEXAS Syndrome: A Diagnostic Conundrum.
The Ulster medical journalA Not-So-Sweet Crohn's Disease: A Case Report of Ileocecal Crohn's Disease Unmasked by Sweet Syndrome.
Case reports in medicineHistiocytoid Sweet Syndrome With Paradoxical Neutropenia in a Pediatric Patient.
Pediatric dermatologyPyoderma gangrenosum: a 22-year follow-up of patients in a tertiary reference hospital in Brazil.
Anais brasileiros de dermatologiaGiant cellulitis-like Sweet syndrome with myofasciitis: Multimodality imaging findings and streptococcal trigger.
Radiology case reports[Classical Sweet syndrome with multiple organ lesions by 18F-FDG PET/CT: A case report].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciencesHistiocytoid Sweet Syndrome as a Manifestation of Myelodysplasia Cutis/Cutaneous VEXAS Syndrome.
The American Journal of dermatopathologyVery rare adverse reactions to intravascular contrast media: From Kounis to sweet syndrome.
European journal of radiologyAcute myeloid leukemia with DEK::NUP214 fusion resembling acute promyelocytic leukemia, initially presenting as sweet syndrome: A case report and literature review.
The Journal of international medical researchNeuro-Sweet's disease manifesting as limbic encephalitis and ventriculitis.
Clinical neurology and neurosurgerySITRAME and Giant Cellulitis-Like Sweet Syndrome: A Spectrum of Autoinflammatory Dermatoses?
International journal of dermatologyReflectance Confocal Microscopy of Sweet Syndrome.
Dermatology practical & conceptualAn Atypical Presentation of Sweet's Syndrome in a Patient With Neutropenia: A Case Report.
CureusInflammatory Signatures in VEXAS Syndrome, Myelodysplasia Cutis, and Sweet Syndrome.
JAMA dermatologyCase Report: First report of Legionella micdadei pneumonia and organizing pneumonia in a patient with myelodysplastic and Sweet syndromes.
Frontiers in immunologyNeutrophilic Dermatosis of the Dorsal Hands.
Journal of Brown hospital medicineSweet Syndrome With Painless Skin Lesions and Myopericarditis: A Case Report and Literature Review.
Clinical case reportsA Case of Sweet's Syndrome Presenting With Tongue Ulcerations.
The Australasian journal of dermatologyCutaneous Hemophagocytosis in a Sweet Syndrome-An Unusual Phenomenon in a Rare Guise.
The American Journal of dermatopathologyRare skin manifestation of tularemia: Sweet syndrome.
Revista da Sociedade Brasileira de Medicina TropicalSweet Syndrome: A Retrospective Analysis of 21 Patients.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSPWound care of Sweet syndrome in a patient with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma: a case report.
Journal of wound careCutaneous Adverse Drug Reactions Associated with SGLT2 Inhibitors.
Journal of clinical medicineClinical Variant of Serpentine Supravenous Hyperpigmentation Following Subcutaneous Bortezomib Injection.
HCA healthcare journal of medicineHydroxychloroquine-induced Sweet's Syndrome: A Case Report and Literature Review.
Acta dermato-venereologicaConceptual Contextualization of Neutrophilic Dermatoses.
The American Journal of dermatopathologyOrbital apex syndrome secondary to Sweet syndrome.
BMJ case reportsSweet Syndrome-Like Disorder Induced by the Oxford-AstraZeneca® SARS-CoV-2 Vaccine.
SkinmedMolecular Characteristics of Sweet Syndrome: A Systematic Review.
Experimental dermatologyDecitabine-induced Sweet syndrome.
BMJ case reportsSweet Syndrome Mimicking Flagellate Dermatitis.
Indian journal of dermatologyAtypical Type 2 Lepra Reaction Masquerading as Recurrent Sweet Syndrome.
Journal of cutaneous pathologyNeurological Sweet's syndrome: a rare but treatable manifestation of an autoinflammatory disease.
Practical neurologyVEXAS Syndrome: Histiocytoid Cells With Feathery Cytoplasm as a Clue to the Diagnosis.
Journal of cutaneous pathologySweet syndrome in patients with and without malignancy: a retrospective study of 66 cases from a tertiary care centre.
European journal of dermatology : EJDA unique case of steroid-resistant, giant cellulitis-like Sweet syndrome mimicking alpha-1-antitrypsin deficiency-associated panniculitis: successful treatment with dapsone.
Clinical and experimental dermatologySweet syndrome: an update on clinical aspects, pathophysiology, and treatment.
Italian journal of dermatology and venereologySweet syndrome with multiorgan involvement exacerbated by gilteritinib.
Leukemia & lymphomaSpesolimab Response in a Patient With Steroid-Resistant Sweet Syndrome.
JAMA dermatologyMimickers of erysipelas and cellulitis: A narrative review.
Indian journal of dermatology, venereology and leprologySweet's Syndrome Unveiling a Primary Cervical Malignancy: A Case Report.
Cureus[Translated article] Giant Cellulitis-like Sweet Syndrome: Contribution of a New Case and Medical Literature Review.
Actas dermo-sifiliograficas[Canine sterile neutrophilic dermatosis (Sweet-like syndrome): A description of 3 cases].
Tierarztliche Praxis. Ausgabe K, Kleintiere/HeimtiereCryptococcoid Sweet syndrome: a case report.
Frontiers in medicineDrug-induced acute febrile neutrophilic dermatosis (Sweet syndrome): A case report presented at Delhi State Cancer Institute.
Journal of cancer research and therapeuticsSubcutaneous Sweet Syndrome With Vasculitis Features: Case Report and Review.
The American Journal of dermatopathologyClinical features, treatment, and outcome of granulocyte colony stimulating factor-induced sweet syndrome.
Archives of dermatological researchGiant cellulitis-like Sweet syndrome mimicking cellulitis: a case report.
Journal of medical case reportsSweet Syndrome Presenting with Features of Cellulitis Shortly after Femoral Angioplasty.
European journal of case reports in internal medicineSuccessful treatment of Sweet syndrome complicated by Behcet disease with adalimumab.
Pediatrics international : official journal of the Japan Pediatric SocietyLongitudinal Presentation and Management of Neutrophilic Dermatosis of the Dorsal Hand: A Case Report Over Six Visits.
CureusDisseminated Yersinia enterocolitica infection associated to Sweet's syndrome.
BMC infectious diseasesVulvar ulcers as a rare manifestation of hematologic malignancy.
JAAD case reportsSweet syndrome after vaccination.
Medicina clinicaA Mysterious Rash Following Cardiothoracic Surgery: A Not So Sweet Ending.
CureusSweet Syndrome in the Central Nervous System: A Case of Orbital Inflammation, Sixth Nerve Palsy, and Pachymeningitis.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology SocietyAseptic Splenic Abscesses With Concomitant Sweet Syndrome as Extraintestinal Manifestations of New-Onset Crohn's Disease.
ACG case reports journalCrusted plaques on the face.
International journal of dermatologyPyoderma Gangrenosum: A Presenting Feature of Rheumatoid Arthritis.
CureusTocilizumab-Induced Sweet Syndrome in a Familial Mediterranean Fever Patient: A Case Report.
Dermatology practical & conceptualNeutrophilic Dermatosis: A Variant of Sweet Syndrome.
Journal of cutaneous medicine and surgeryMucocutaneous manifestations of inflammatory bowel disease.
Annales de dermatologie et de venereologieHistiocytoid Pyoderma Gangrenosum: A Challenging Case With Features of Sweet Syndrome.
CutisSweet syndrome associated with moderate leukocyte adhesion deficiency type I: a case report and review of the literature.
Frontiers in immunologyPyrin-associated autoinflammation with neutrophilic dermatosis: A case report.
The Journal of dermatologyCase 22-2024: A 30-Year-Old Woman with Postpartum Fever, Abdominal Pain, and Skin Ulcers.
The New England journal of medicineA case of Sweet's syndrome successfully treated with minocycline.
European journal of dermatology : EJDMyelodysplasia cutis and VEXAS syndrome initially diagnosed as histiocytoid Sweet syndrome: A diagnostic pitfall.
Journal of cutaneous pathologyVEXAS syndrome: A 2-case series report.
Reumatologia clinicaNeonatal Sweet syndrome with associated rectovestibular fistula and review of the literature.
Pediatric dermatologySweet syndrome in pregnancy: A narrative review.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and ObstetricsSkin Manifestations of VEXAS Syndrome and Associated Genotypes.
JAMA dermatologyOne case of Sweet Syndrome after treatment of MDS-RS-MLD with azactidine and literature review.
Minerva medicaBowel-associated dermatosis-arthritis syndrome, a diagnostic challenge in a young child with very early-onset inflammatory bowel disease.
Pediatric dermatologyA Rare Case of Drug-Induced Sweet Syndrome After Pembrolizumab Therapy.
CureusNeutrophilic dermatosis of the dorsal hands in a Mexican woman.
Anais brasileiros de dermatologiaSingle-lesion sporotrichosis triggering Sweet's syndrome.
Anais brasileiros de dermatologiaDrug-Induced and Malignancy-Associated Neutrophilic Dermatoses in Patients with Hematologic Malignancies: A Single Institution Experience.
Dermatology (Basel, Switzerland)Histiocytoid Sweet's Syndrome in the Setting of Myelodysplastic Syndrome.
CureusReflectance confocal microscopy in pediatric patients with Sweet's syndrome: a useful method to differentiate from discoid lupus erythematosus.
Archives of dermatological researchBrodalumab for the treatment of refractory Sweet syndrome.
International journal of dermatologySweet Syndrome as a Herpetiform Mimic: A Diagnostic Challenge.
The American Journal of dermatopathologySuspected coexistence of perianal necrotizing sweet syndrome in chronic myelomonocytic leukemia: A case report.
World journal of gastrointestinal surgeryNoninflammatory extrafacial edema as a clue to the diagnosis of vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome.
JAAD case reportsSweet syndrome with peripheral neuropathy in a patient with metastatic clear cell renal cell carcinoma.
BMJ case reportsSweet syndrome and acute pulmonary coccidioidomycosis in West Texas.
JAAD case reportsSweet syndrome and secondary syphilis: a rare association that should not be missed.
Italian journal of dermatology and venereologyTo ASLO or Not to ASLO: Utility of the ASLO Test in Dermatology.
The Israel Medical Association journal : IMAJAn atypical facial eruption in skin of color: A rare presentation of histiocytoid Sweet syndrome.
JAAD case reportsSweet syndrome induced by FLT3 inhibitors: case report and literature review.
Hematology (Amsterdam, Netherlands)Sweet or Not? Azathioprine-Induced Sweet Syndrome Mimicking Erythema Nodosum in a Patient With Inflammatory Bowel Disease.
ACG case reports journalProteasome inhibitor-associated histiocytoid Sweet's syndrome: Clinical and histological similarities to Nakajo-Nishimura syndrome suggest a potential mechanism.
The Journal of dermatologyCOVID-19 vaccination-induced Sweet syndrome in a patient with squamous cell carcinoma treated with nivolumab.
European journal of dermatology : EJDDescription of a novel splice site variant in UBA1 gene causing VEXAS syndrome.
Rheumatology (Oxford, England)Comparative immunohistochemical analysis of inflammatory cytokines in distinct subtypes of Sweet syndrome.
Frontiers in immunologyPeriorbital necrotizing sweet syndrome: A report of two cases mimicking necrotizing soft tissue infections.
American journal of ophthalmology case reportsA case of filgrastim-induced neutrophilic dermatosis of the dorsal hands in a patient with Felty Syndrome.
Dermatology online journalPulmonary coccidioidomycosis mimicking malignancy associated with Sweet's syndrome (acute febrile neutrophilic dermatosis).
Clinical case reportsNeutrophilic Dermatosis of the Hands: A Case Report.
Acta dermatovenerologica Croatica : ADCSweet syndrome in a patient receiving encorafenib and binimetinib therapy for malignant melanoma.
JAAD case reportsNeutrophilic Dermatoses: A Medley of Inflammatory Cutaneous and Systemic Disorders.
Dermatologic clinicsQuality of Life with Neutrophilic Dermatoses.
Dermatologic clinicsNeutrophilic Panniculitides.
Dermatologic clinicsPediatric Neutrophilic Dermatoses.
Dermatologic clinicsNeutrophilic Urticarial Dermatosis.
Dermatologic clinicsFrom Histiocytoid Sweet Syndrome to Myelodysplasia Cutis: History and Perspectives.
Dermatologic clinicsSweet Syndrome and Neutrophilic Dermatosis of the Dorsal Hands.
Dermatologic clinicsOverview of Neutrophilic Biology, Pathophysiology, and Classification of Neutrophilic Dermatoses.
Dermatologic clinicsThe Neutrophilic Dermatoses, or the Cutaneous Expressions of Neutrophilic Inflammation.
Dermatologic clinicsMercaptopurine-induced Sweet's syndrome.
BMJ case reportsNeutrophilic dermatosis in a patient with an IKZF1 variant and a review of monogenic autoinflammatory disorders presenting with neutrophilic dermatoses.
Pediatric dermatologyCryptococcoid Sweet syndrome: A case report and literature review.
International journal of dermatologyClinical and histological features of histiocytoid Sweet syndrome associated with VEXAS syndrome.
Clinical and experimental dermatologyCase Report: Type 2 Leprosy Reaction Mimicking Sweet Syndrome: A Case Report and Literature Review.
The American journal of tropical medicine and hygieneParadoxical skin reaction to certolizumab, an overlap of neutrophilic dermatoses.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDGMultiple Abscess Collections: Antibiotics or Steroids?
Case reports in immunologyRheumatoid-associated chronic recurrent annular neutrophilic dermatosis.
European journal of dermatology : EJDSweet syndrome in a patient with rectal adenocarcinoma and HIV following neoadjuvant chemoradiation.
JAAD case reports[Translated article] Patient With Relapsing Polychondritis and Cutaneous Nodules Being Followed by the Hematology Department for a Myelodysplastic Syndrome.
Actas dermo-sifiliograficasSweet syndrome following the ChAdOx1-S vaccine.
BMJ case reportsNeutrophil extracellular traps and neutrophilic dermatosis: an update review.
Cell death discoveryPreface to Journal of Dermatology special issue: Neutrophilic dermatoses and autoinflammation.
The Journal of dermatologyConcurrent Sweet syndrome and erythema nodosum.
Proceedings (Baylor University. Medical Center)VEXAS syndrome: Clinical manifestations, diagnosis, and treatment.
Reumatologia clinicaPersistent Sweet syndrome post-hematopoietic stem cell transplantation heralding molecular relapse of myelofibrosis.
American journal of hematologyClinical characteristics, disease trajectories and management of vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome: a systematic review.
Rheumatology internationalSweet Syndrome: Clinical Presentation, Malignancy Association, Autoinflammatory Disorders and Treatment Response in a Cohort of 93 Patients with Long-term Follow-up.
Acta dermato-venereologicaA diagnostic challenge-First case of chronic lymphatic leukemia-associated necrotizing sweet syndrome.
European journal of haematologyA Not-So-Sweet Syndrome: A Case Report of a Male Presenting With Acute Febrile Neutrophilic Dermatosis.
CureusNeutrophilic Dermatosis of the Dorsal Hand: A Distinctive Variant of Sweet Syndrome.
CutisProgressive, edematous plaques, mild pancytopenia, and inflammation.
JAAD case reportsSweet Syndrome With Vasculitis: Time To Adopt a New Criteria?
CureusNeutrophilic Dermatosis of Dorsal Hands as Paradoxical Reaction to Infliximab Treatment.
SkinmedAn uncommon culprit of neutropenic fever: a case of Sweet syndrome following induction therapy for acute myeloid leukemia.
Archive of clinical casesPainful plaques in a woman with recurrent squamous cell carcinoma.
JAAD case reportsAcute Febrile Neutrophilic Dermatosis (Sweet Syndrome) in Acute Myeloid Leukemia Patients: A 28-Year Institutional Experience.
Acta haematologicaCutaneous vasculitis in autoinflammatory diseases.
The Journal of dermatologyVEXAS-Syndrome, a newly described autoinflammatory systemic disease with dermatologic manifestations.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDGAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Extraintestinal Cutaneous Manifestations in Inflammatory Bowel Disease Among Non-White Patients: A Retrospective Multicenter Study.
- Clinicopathologic Spectrum of Dermatological Diseases in Patients with Acute Myeloid Leukemia (AML): A Retrospective Study in AML Patients with Cutaneous Manifestations.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion· 2026· PMID 41522545mais citado
- Myeloid dermatosis with features of sweet syndrome and leukemia cutis: a case report.
- Wrong Place at the Right Height: Scalp Orf in a Toddler With Dense Dermal Neutrophilic Infiltrate Mimicking Sweet Syndrome.
- From Aortitis to Sweet's: The Immune Spectrum of G-CSF Adverse Events.
- A Rare Hybrid Presentation: Coexistence of Necrotizing and Histiocytoid Variants of Sweet Syndrome (SS) in a Patient With Acute Myeloid Leukemia (AML).
- Subcutaneous Sweet Syndrome as an uncommon mucocutaneous manifestation in systemic lupus erythematosus: a case report and literature review.
- Vaping and Orthopaedic Surgery: A scoping review of the literature.
- Sweet Syndrome in a Patient With Adult-Onset Immunodeficiency Due to Anti-Interferon-Gamma Autoantibodies: A Case Report and Brief Review of the Literature.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:3243(Orphanet)
- OMIM OMIM:608068(OMIM)
- MONDO:0011959(MONDO)
- GARD:521(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q1514476(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
