Raras
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Tumor fibroso solitário
ORPHA:2126CID-10 · D21.9DOENÇA RARA

O tumor fibroso solitário (TFS) é um tipo raro de tumor, formado por células alongadas (chamadas células fusiformes), que pode aparecer em diversas partes do corpo. Ele pode ser benigno (não-canceroso) ou maligno (canceroso). Geralmente, surge com mais frequência na pleura (membrana que recobre o pulmão) e no peritônio (membrana que reveste o abdômen), e mais raramente em outras partes como cabeça e pescoço, fígado e músculos. O TFS pode não apresentar sintomas ou pode se manifestar como uma massa que cresce, causando efeitos de compressão nos órgãos vizinhos, dependendo do local onde está. Mais raramente, pode causar sintomas incomuns que afetam outras partes do corpo (chamados de manifestações paraneoplásicas), como problemas nas articulações e ossos (osteoartropatia) ou baixo açúcar no sangue (hipoglicemia).

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Introdução

O que você precisa saber de cara

📋

O tumor fibroso solitário (TFS) é um tipo raro de tumor, formado por células alongadas (chamadas células fusiformes), que pode aparecer em diversas partes do corpo. Ele pode ser benigno (não-canceroso) ou maligno (canceroso). Geralmente, surge com mais frequência na pleura (membrana que recobre o pulmão) e no peritônio (membrana que reveste o abdômen), e mais raramente em outras partes como cabeça e pescoço, fígado e músculos. O TFS pode não apresentar sintomas ou pode se manifestar como uma massa que cresce, causando efeitos de compressão nos órgãos vizinhos, dependendo do local onde está. Mais raramente, pode causar sintomas incomuns que afetam outras partes do corpo (chamados de manifestações paraneoplásicas), como problemas nas articulações e ossos (osteoartropatia) ou baixo açúcar no sangue (hipoglicemia).

Pesquisas ativas
3 ensaios
101 total registrados no ClinicalTrials.gov
Publicações científicas
3.073 artigos
Último publicado: 2026 Jun
Medicamentos
5 registrados
DOXORUBICIN HYDROCHLORIDE, DOXORUBICIN, AXITINIB

Tem tratamento?

5 medicamentos registrados
Ver detalhes, fases e interações →
DOXORUBICIN HYDROCHLORIDEDOXORUBICINAXITINIBERIBULINPAZOPANIB

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: D21.9
Você se identifica com essa condição?
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

📏
Crescimento
4 sintomas
🫃
Digestivo
2 sintomas
🫘
Rins
1 sintomas
😀
Face
1 sintomas
🫁
Pulmão
1 sintomas
❤️
Coração
1 sintomas

+ 21 sintomas em outras categorias

Características mais comuns

17%prev.
Neoplasia da pleura
Ocasional (29-5%)
17%prev.
Neoplasia
Ocasional (29-5%)
17%prev.
Neoplasia de tecido mole
Ocasional (29-5%)
17%prev.
Fadiga
Ocasional (29-5%)
17%prev.
Neoplasia genital
Ocasional (29-5%)
17%prev.
Perda de peso
Ocasional (29-5%)
31sintomas
Ocasional (6)
Muito raro (23)
Sem dados (2)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 31 características clínicas mais associadas, ordenadas por frequência.

Neoplasia da pleuraNeoplasia of the pleura
Ocasional (29-5%)17%
NeoplasiaNeoplasm
Ocasional (29-5%)17%
Neoplasia de tecido moleSoft tissue neoplasm
Ocasional (29-5%)17%
FadigaFatigue
Ocasional (29-5%)17%
Neoplasia genitalGenital neoplasm
Ocasional (29-5%)17%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico3.073PubMed
Últimos 10 anos200publicações
Pico2025149 papers
Linha do tempo
2026Hoje · 2026🧪 1994Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

Genes associados

2 genes identificados com associação a esta condição. Padrão de herança: Not applicable.

NAB2NGFI-A-binding protein 2Part of a fusion gene inAltamente restrito
FUNÇÃO

Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity)

LOCALIZAÇÃO

Nucleus

VIAS BIOLÓGICAS (2)
EGR2 and SOX10-mediated initiation of Schwann cell myelinationNGF-stimulated transcription
EXPRESSÃO TECIDUAL(Ubíquo)
Ovário
111.5 TPM
Cérebro - Hemisfério cerebelar
109.0 TPM
Cerebelo
105.4 TPM
Útero
93.4 TPM
Cervix Endocervix
91.4 TPM
OUTRAS DOENÇAS (1)
solitary fibrous tumor
HGNC:7627UniProt:Q15742
STAT6Signal transducer and activator of transcription 6Part of a fusion gene inRestrito
FUNÇÃO

Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling

LOCALIZAÇÃO

CytoplasmNucleus

VIAS BIOLÓGICAS (3)
Interleukin-4 and Interleukin-13 signalingDownstream signal transductionSTAT6-mediated induction of chemokines
MECANISMO DE DOENÇA

Hyper-IgE syndrome 6, autosomal dominant, with recurrent infections

An immunologic disorder characterized by severe allergic disease with onset in infancy. Common features are treatment-resistant atopic dermatitis, food allergies, asthma, eosinophilic gastrointestinal disease, and severe episodes of anaphylaxis. Half of the patients present with recurrent skin, respiratory, and viral infections. Clinical laboratory testing is notable for eosinophilia and markedly elevated serum IgE levels.

EXPRESSÃO TECIDUAL(Ubíquo)
Ovário
219.3 TPM
Cervix Endocervix
215.3 TPM
Baço
213.2 TPM
Cervix Ectocervix
212.7 TPM
Útero
205.9 TPM
OUTRAS DOENÇAS (2)
hyper-IgE syndrome 6, autosomal dominant, with recurrent infectionssolitary fibrous tumor
HGNC:11368UniProt:P42226

Medicamentos e terapias

DOXORUBICIN HYDROCHLORIDEPhase 3

Mecanismo: DNA topoisomerase II alpha inhibitor

DOXORUBICINPhase 3

Mecanismo: DNA topoisomerase II alpha inhibitor

AXITINIBPhase 2

Mecanismo: Vascular endothelial growth factor receptor inhibitor

ERIBULINPhase 2

Mecanismo: Tubulin inhibitor

PAZOPANIBPhase 2

Mecanismo: Fibroblast growth factor receptor 3 inhibitor

Ver mais no OpenTargets

Variantes genéticas (ClinVar)

26 variantes patogênicas registradas no ClinVar.

🧬 STAT6: NM_003153.5(STAT6):c.3G>A (p.Met1Ile) ()
🧬 STAT6: NM_003153.5(STAT6):c.791T>C (p.Val264Ala) ()
🧬 STAT6: NM_003153.5(STAT6):c.1606C>G (p.Arg536Gly) ()
🧬 STAT6: NM_003153.5(STAT6):c.1114G>A (p.Glu372Lys) ()
🧬 STAT6: NM_003153.5(STAT6):c.1555G>C (p.Asp519His) ()
Ver todas no ClinVar

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
3Fase 32
2Fase 27
1Fase 12
·Pré-clínico5
Medicamentos catalogadosEnsaios clínicos· 5 medicamentos · 11 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Tumor fibroso solitário

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

3 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

101 ensaios clínicos encontrados, 3 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

🥉Melhor nível de evidência: Relato de caso
Timeline de publicações
1.827 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 1.827

#1

Effectiveness of classification and scoring systems in solitary fibrous tumor prognosis prediction.

Pakistan journal of medical sciences2026 Feb

Because thoracic solitary fibrous tumors (SFTs) are rare, there is limited information on their clinical features, treatment, and follow-up. The literature mainly comprises individual case reports. Our study aimed to analyse SFT data to identify prognosis-related factors and to compare the performance of two describing approaches and three risk stratification models. We conducted a retrospective review of medical data from 37 patients, including 32 patients with SFT aged 18 years and older who underwent surgical treatment and five patients diagnosed by biopsy at Kocaeli University Hospital between January 2004 and December 2024. Parameters affecting recurrence and survival were investigated, and the effectiveness of existing classification and scoring systems was compared. Factors potentially associated with recurrence included four or more mitoses (10 HPF) (p=0.023), necrosis (p=0.007), at least 10% Ki-67 positivity (p=0.012), malignancy (p=0.046), and tumor size (p=0.022). Relapses were observed only in the malignant group according to the England classification (p=0.046), only in stage-3 according to the de Perrot classification (p=0.161), only in those with scores of three or higher according to the Tapias classification (p=0.036), only in those with scores of two or higher according to the Diebold classification (p=0.021), and all in high-stage groups (p=0.001) according to the Demicco classification. All recurrences occurred at significant or high scores. The Tapias, Diebold, and Demicco scoring systems are highly effective in predicting recurrence and prognosis. However, the modified Demicco system is more advantageous and offers a higher level of assessment.

#2

Beyond the Globe: Molecular Diagnostics of Optic Nerve, Orbital, and Adnexal Neoplasms.

Translational vision science &amp; technology2026 Mar 02

Recent advances in molecular pathology have transformed the diagnostic landscape and management of human cancer. Increasingly, integration of genomic and epigenomic data with conventional histopathology has improved tumor classification, refined prognostic assessment, and revealed previously unsuspected therapeutic targets. High-throughput techniques such as next-generation sequencing, gene fusion panels, and methylation arrays have expanded applicability to formalin-fixed tissue and enabled simultaneous evaluation of multiple cancer-defining alterations/genetic drivers. In optic nerve gliomas, MAPK pathway activation through BRAF or FGFR1 alterations, or NF1 inactivation, is a basic biological feature with diagnostic implications, while MEK inhibitors may be of clinical benefit in selected patients. Optic nerve sheath/orbital meningiomas demonstrate divergent molecular landscapes depending on location, with NF2-driven and non-NF2-driven pathways informing recurrence risk and behavior. In the orbit, characteristic genetic drivers facilitate diagnosis of mesenchymal tumors such as solitary fibrous tumor (NAB2::STAT6) and alveolar rhabdomyosarcoma (PAX3/7::FOXO1), while molecular profiling assists in distinguishing challenging peripheral nerve and melanocytic lesions. Similarly, lacrimal gland neoplasms parallel salivary gland counterparts, with recurrent fusions such as PLAG1, HMGA2, and MYB::NFIB of great diagnostic utility. These advances underscore the growing role of molecular diagnostics in improving accuracy, guiding prognostication, and refining the classification of rare ocular tumors. As high-throughput techniques continue to mature, integration with evolving spatial and single-cell-based approaches promises to expand our understanding and further personalize diagnostic and therapeutic strategies.

#3

Incidentally detected multifocal calcifying fibrous tumour of the pleura: a diagnostic enigma.

BMJ case reports2026 Jan 12

Calcifying fibrous tumour of the pleura (CFTP) is a rare, benign soft tissue neoplasm with uncertain aetiology. To our knowledge, only 36 cases (including this case) have been reported in English literature. A man in his early 30s presented with an incidental pleural lesion identified following investigation for a persistent cough. Imaging revealed left pleural thickening with calcification, raising concern for a possible malignant pleural process. CT-guided biopsy demonstrated fibrosis without malignancy, and a video-assisted thoracoscopic surgery excision was performed. Histopathology confirmed multifocal CFTP. This case highlights the diagnostic challenges posed by pleural-based calcified lesions and reinforces the importance of surgical excision for both diagnosis and cure. The rarity of CFTPs, their benign course and their potential to mimic malignancy are discussed alongside a review of the current literature.

#4

Intracranial solitary fibrous tumor with myxoid features: An unusual presentation.

Journal of neuropathology and experimental neurology2026 Mar 06
#5

A case of orbital solitary fibrous tumor with fast-growing budding morphology.

Orbit (Amsterdam, Netherlands)2026 Mar 23

Orbital solitary fibrous tumors (SFTs) are rare and are typically benign and slow‑growing. This report details a unique case of a rapidly progressing benign orbital SFT in a 75-year-old man with recurrent prostate cancer. Magnetic Resonance Imaging (MRI) initially revealed an extraconal mass, which, within five months, evolved significantly. Surgical excision revealed a primary encapsulated mass and a smaller, intimately attached, "budding" satellite nodule. Histopathology confirmed benign SFT characteristics with low mitotic activity and strong nuclear STAT6 and CD34 immunoreactivity. This case is notable for its rapid growth and presentation in an older patient with cancer, expanding the known morphological spectrum and growth kinetics of orbital SFTs. While the observation raises a hypothesis regarding potential systemic or hormonal influences, no receptor, molecular, or serum studies were performed to support a causal relationship. Overall, this case underscores the importance of thorough intraoperative exploration, continuous surveillance, and prompts further investigation into systemic or hormonal influences on SFT growth.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC2.256 artigos no totalmostrando 198

2026

A case of orbital solitary fibrous tumor with fast-growing budding morphology.

Orbit (Amsterdam, Netherlands)
2026

Intraosseous Solitary Fibrous Tumor of the Maxilla: A Report of an Unusual Case.

Cureus
2026

Intraoperative vascular ligation uncovers the role of tumor vasculature in Doege-Potter syndrome: a case report.

Frontiers in oncology
2026

A hepatic solitary fibrous tumor with giant cells and a review of the literature.

Discover oncology
2026

Pediatric intracranial high-grade solitary fibrous tumor/hemangiopericytoma with drop metastasis to cervicodorsal spine: a rare case report.

International journal of surgery case reports
2026

Case report: diagnosis and surgical management of a rare malignant isolated fibrous tumor of the pelvis.

Journal of surgical case reports
2026

Effectiveness of classification and scoring systems in solitary fibrous tumor prognosis prediction.

Pakistan journal of medical sciences
2026

Haemangiopericytoma and solitary fibrous tumour of the parotid gland: a scoping review.

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale
2026

Complete Resection of a Giant Hypervascular Pelvic Floor Solitary Fibrous Tumor Using Intraoperative Balloon Occlusion and Staged Open Abdomen Management: A Case Report.

Surgical case reports
2026

Clinical Features of Solitary Fibrous Tumor: Insights From a Single Center Experience.

Journal of surgical oncology
2026

Intracranial solitary fibrous tumor with myxoid features: An unusual presentation.

Journal of neuropathology and experimental neurology
2026

Intracerebral Hemorrhage Secondary to Solitary Fibrous Tumor: A Case Report.

Cureus
2026

Beyond the Globe: Molecular Diagnostics of Optic Nerve, Orbital, and Adnexal Neoplasms.

Translational vision science &amp; technology
2026

[Perioperative Crew Resource Management: an Example of Interdisciplinary Collaboration].

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
2026

Myxoid Solitary Fibrous Tumor of the Vulva: A Diagnostic Pitfall.

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
2026

Clinicopathological characteristics and outcomes of 42 cases of ocular adnexal sarcoma.

International ophthalmology
2026

Clinicopathological, Radiological, and Prognostic Profile of Solitary Fibrous Tumor of Central Nervous System: A Single Institutional Experience.

Indian journal of surgical oncology
2026

Hepatic solitary fibrous tumor.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
2026

Solitary fibrous tumor of the sublingual gland: a case report.

Frontiers in oral health
2026

Lower Lip Nodule in an Elderly Woman: Challenge.

The American Journal of dermatopathology
2026

Lower Lip Nodule in an Elderly Woman: Answer.

The American Journal of dermatopathology
2026

Primary radiotherapy for intraorbital solitary fibrous tumor: a case report with 5-year follow-up.

Orbit (Amsterdam, Netherlands)
2026

Solitary Fibrous Tumor With a 12-Year Recurrence Interval in a Female Patient: A Case Report.

Cureus
2026

Solitary Fibrous Tumors of the Head and Neck: A Report of Two Cases and Review of the Literature.

Cureus
2026

The role of surgery plus radiation versus surgery alone in the management for complicated orbital solitary fibrous tumor: a new insight on a rare disease.

BMC cancer
2026

Resolution of Refractory Nonislet Cell Tumor Hypoglycemia Following Resection of an Abdominal Solitary Fibrous Tumor.

AACE endocrinology and diabetes
2026

A Rare Case of a Solitary Fibrous Tumor of the Prostate: A Case Report.

Cureus
2025

Solitary Fibrous Tumor of the Oropharyngeal Lateral Wall: A Case Report and Review of Diagnostic and Therapeutic Challenges.

Cureus
2026

Subcutaneous Solitary Fibrous Tumor in the Chin of a Young Adult: A Diagnostic Challenge.

The American journal of case reports
2026

Single-Fraction Stereotactic Radiosurgery for Residual, Recurrent, or Metastatic Intracranial Solitary Fibrous Tumors: An IRRF Study Toward Management Guidance.

Neuro-oncology
2026

FDG-PET/CT SUVmax Predicts Recurrence Risk of Resected Pleuropulmonary Solitary Fibrous Tumors.

JTO clinical and research reports
2026

Silent but suspicious: the clinical significance of slowly expanding PET-negative lung nodules.

Journal of cardiothoracic surgery
2025

Solitary fibrous tumor of the chest wall with Doege-Potter syndrome: a case report.

Frontiers in oncology
2025

Distant metastasis of intracranial solitary fibrous tumor preceding resection: illustrative case.

Journal of neurosurgery. Case lessons
2026

Proceedings of the 2026 North American Society of Head and Neck Pathology Companion Meeting, San Antonio, TX, March 22, 2026: It's a Trap!: Diagnostic Pitfalls in Sinonasal Pathology.

Head and neck pathology
2026

Validation of a seven-gene predictive SIGNature for the efficacy of Immuno-Oncology PD-1 inhibitors in patients with Sarcoma (SIGNIOS).

Clinical cancer research : an official journal of the American Association for Cancer Research
2026

Pathologic Assessment of Retroperitoneal Sarcomas: A Position Paper By the Transatlantic Australasian Retroperitoneal Sarcoma Working Group.

The American journal of surgical pathology
2026

Solitary fibrous tumor: an updated review.

Journal of pathology and translational medicine
2026

CD 34 negative orbital solitary fibrous tumor: report of a rare case with prognostic implications.

Orbit (Amsterdam, Netherlands)
2026

Incidentally detected multifocal calcifying fibrous tumour of the pleura: a diagnostic enigma.

BMJ case reports
2025

Rare malignant cervical solitary fibrous tumor.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
2026

Contrast-Enhanced Harmonic Endoscopic Ultrasonography for Diagnosing Gastric Subepithelial Tumors.

Diagnostics (Basel, Switzerland)
2025

Prognostic clinical and pathological factors in intrathoracic solitary fibrous tumors: A retrospective single-center study.

Turk gogus kalp damar cerrahisi dergisi
2025

Solitary Fibrous Tumor of Uterine Cervix: A Rare Entity Mimicking Clinically as Carcinoma Cervix.

International journal of applied &amp; basic medical research
2026

Intraocular Solitary Fibrous Tumor.

Ophthalmology. Retina
2026

Solitary Fibrous Tumor With Doege-Potter Syndrome Successfully Treated With Preoperative Transcatheter Arterial Embolization and Complete Excision; A Case Report.

IJU case reports
2026

First In Vivo Monitoring of Helium-Ion Radiation Therapy With Secondary Ions.

International journal of radiation oncology, biology, physics
2025

Periprosthetic Solitary Fibrous Tumor of the Proximal Femur: A Case Report.

JBJS case connector
2026

Localization of Persistent Air Leaks Using Technetium-99m Technegas SPECT/CT.

Clinical nuclear medicine
2025

Robotic subxiphoid surgical approach for mediastinal lesions: One-year experience.

World journal of clinical cases
2025

Refining Risk Stratification and Surveillance Strategies in Pleuropulmonary Solitary Fibrous Tumors-An International, Retrospective, Multicenter Analysis.

Cancers
2025

Malignant metastatising solitary fibrous tumor of the ovary with additional dedifferentiation and osteoid deposition: an unusual presentation, with a brief description of a diagnostic alghoritm.

Pathologica
2025

Solitary Fibrous Tumor of the Nasal Vestibule: A Case Report.

Cureus
2026

11 C-Methionine PET for Detecting Solitary Fibrous Tumor Metastases: 2 Cases With Negative FDG-PET.

Clinical nuclear medicine
2025

An Unusual Cause of Hypoglycemia: Doege-Potter Syndrome-A Case Report and Review of Literature.

Indian journal of surgical oncology
2025

Malignant solitary fibrous tumor of the temporal bone with NAB2 ex6::STAT6 ex16 fusion: a case report with literature review.

World journal of surgical oncology
2025

A Rare Metastatic Fibrous Tumor: Review of Literature With a Case Report.

JTO clinical and research reports
2025

Primary Pulmonary Osteosarcoma Presenting as a 1.7-cm Subpleural Nodule in a 61-Year-Old Man: A Case Report.

The American journal of case reports
2025

The first case of GOLGA5-RET fusion-positive malignant spindle cell sarcoma of the head and neck responsive to selpercatinib.

International cancer conference journal
2025

Large Thoracic Solitary Fibrous Tumor: A Case Report.

Case reports in oncology
2025

Radiation therapy alleviates Doege-Potter syndrome accompanied with severe aortic valve insufficiency: a case report and literature review.

Frontiers in oncology
2025

Beyond COL1A1::PDGFB: Rare fusions and their clinical implications in dermatofibrosarcoma protuberans.

World journal of clinical cases
2025

[Renal solitary fibrous tumors: a clinicopathological analysis of five cases].

Zhonghua bing li xue za zhi = Chinese journal of pathology
2026

Solitary Fibrous Tumors of the Chest: Case Series from a Portuguese Center.

Acta medica portuguesa
2026

Uncommon Spindle Cell Tumors of the Pleura.

Advances in anatomic pathology
2025

A Prostatic Extra-Gastrointestinal Stromal Tumor Treated by Surgery: A Case Report with 7-Year Follow-Up and Review of Literature.

Archivos espanoles de urologia
2025

Incidental Early Pancreatitis Detected on 18F-FDG and 68Ga-FAPI-46 PET/CT in a Patient With Metastatic Soft Tissue Sarcoma Undergoing 177Lu-FAPI-2286 Therapy.

Clinical nuclear medicine
2025

A Rare Case of a Huge Solitary Fibrous Tumor in the Kidney.

Medical archives (Sarajevo, Bosnia and Herzegovina)
2026

Cytologic and Histologic Findings of Extrapleural Solitary Fibrous Tumor: Report of Two Cases.

Diagnostic cytopathology
2025

90Y-FAPI-46 Theranostic for Solitary Fibrous Tumor Shows Promising Early Results.

Radiology. Imaging cancer
2025

Initial experience with ihtOBTURA®: A novel EVOH-based embolic agent in the preoperative embolization of hypervascular head, neck, and spinal tumors.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
2025

Prostatic Solitary Fibrous Tumor With Pulmonary Metastases: A Case Report.

Cureus
2025

[Effectiveness evaluation of three-dimensional printed customized hemi-pelvic prosthesis for pelvic reconstruction after resection of massive pelvic tumor].

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
2025

The Solitary Fibrous Tumor, the Chameleon of the Head and Neck Region-Clinical, Epidemiological, and Histopathological Aspects.

Diagnostics (Basel, Switzerland)
2025

Solitary Fibrous Tumour Presenting as Delayed Neck Swelling Following Carotid Endarterectomy.

Cureus
2025

Doege-Potter syndrome in a patient with solitary fibrous tumor of the retroperitoneum: a case report and literature review.

Discover oncology
2025

Solitary Fibrous Tumor of the Mesentery of the Small Intestine: A Rare Case Report.

Journal of the anus, rectum and colon
2025

Solitary Fibrous Tumor of the Renal Hilar in a 52-Year-Old Woman: A Case Report.

Clinical case reports
2025

Non-Islet Cell Tumor Hypoglycemia Masquerading as Diabetes Remission in a Patient With Type 2 Diabetes Mellitus.

JCEM case reports
2025

Identification of BET inhibitors (BETi) against solitary fibrous tumor (SFT) through high-throughput screening (HTS).

Neoplasia (New York, N.Y.)
2025

Spectrum and Clinical Impact of Secondary Genetic Alterations in Translocation-Associated Sarcomas.

JCO precision oncology
2025

Malignant solitary fibrous tumor of the kidney with extracapsular extension beyond the renal capsule: An extremely rare Uro-oncological surgical case and diagnostic challenge.

Urology case reports
2025

Imaging Characteristics of Hemangiopericytoma: A Case Report.

Cureus
2025

Solitary Fibrous Tumor of the Forehead.

Indian dermatology online journal
2025

A rare case: solitary fibrous tumor with widespread metastasis on [68Ga]Ga-DOTATATE PET/CT.

European journal of nuclear medicine and molecular imaging
2025

Laparoscopic resection of a giant pelvic solitary fibrous tumor: a case report.

Frontiers in oncology
2025

Solitary Fibrous Tumor of the Pleura Presenting as a Giant Thoracic Mass: A Case Report.

Clinical case reports
2025

Recurrent dermatofibrosarcoma protuberans involving the lacrimal sac: A case report.

World journal of clinical cases
2025

Interdisciplinary management of a solitary fibrous tumor of the pleura complicated by Doege-Potter syndrome.

JTCVS techniques
2025

Solitary fibrous tumor of the pancreas in a patient with tumor duplicity: a case report.

Ceskoslovenska patologie
2025

Robot-assisted laparoscopic prostate-sparing resection of an extremely rare periprostatic solitary fibrous tumor: a case report and literature review.

World journal of surgical oncology
2025

Solitary fibrous tumor of the prostate: a case report and the systematic review of 74 published cases.

Frontiers in oncology
2025

Recurrence of Solitary Fibrous Tumour of the Pleura: A 20-Years Bi-centric Study with Risk Score Comparison.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
2025

Solitary fibrous tumor of the prostate: Case report and literature review.

Urology case reports
2025

Thoracic intradural extramedullary solitary fibrous tumor: A case report and review of the literature.

Surgical neurology international
2025

[Analysis of short-term efficacy and safety of transnasal endoscopic approach and the combined transconjunctival-endoscopic approach in resection of benign orbital apex lesions].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
2025

Pediatric Spinal Solitary Fibrous Tumor: A Systematic Review of a Rare Condition.

Children (Basel, Switzerland)
2025

Recurrent Solitary Fibrous Tumors in the Orbit.

International ophthalmology clinics
2025

Thoracoscopic Resection of a Giant Solitary Fibrous Tumor in the Chest Cavity After Preoperative Arterial Embolization: A Case Report.

Cureus
2025

Pectoralis Major Myocutaneous Flap Reconstruction in Locally Advanced Head and Neck Malignant Solitary Fibrous Tumors: Functional and Oncologic Outcomes.

The Journal of craniofacial surgery
2025

3D-guided cadaveric fibula reconstruction for pediatric infratemporal solitary fibrous tumor.

Case reports in plastic surgery &amp; hand surgery
2025

Spinal Extradural Solitary Fibrous Tumor Arising at the Level of T12 Vertebra: A Rare and Challenging Diagnosis.

Cureus
2025

Solitary fibrous tumor of kidney and renal hilus: a multi-institutional clinicopathologic analysis of 43 cases.

Virchows Archiv : an international journal of pathology
2025

Impact of adjuvant therapy on survival in treatment of CNS hemangiopericytomas.

Cancer treatment and research communications
2025

WHO Grade II or III Solitary Fibrous Tumors (Hemangiopericytomas) of the Spine: Two Case Reports with a Comprehensive Review of the Literature.

Journal of clinical medicine
2026

Unusual Case of Multiple and Delayed Recurrence of a Solitary Fibrous Tumor of the Pleura After Complete Resection.

Archivos de bronconeumologia
2026

Radiation Therapy for Solitary Fibrous Tumor of the Orbit.

Ophthalmic plastic and reconstructive surgery
2025

Operative Technique in a Resection of Solitary Fibrous Tumor within the Sigmoid Sinus: Technical Note and Case Presentation.

Journal of neurological surgery. Part A, Central European neurosurgery
2025

Solitary Fibrous Tumor of the Stomach: Diagnostic Pitfalls and Clinical Implications.

Surgical case reports
2025

Intraventricular metastasis with malignant progression of an intraspinal solitary fibrous tumor: a case report and review of the literature.

Journal of medical case reports
2025

Long-term follow-up outcomes in intracranial solitary fibrous tumor compared with meningioma: a propensity score matching study.

Journal of neurosurgery
2025

Meningeal Solitary Fibrous Tumor: A Cytological Report With Emphasis on the Usefulness of Immunocytochemical Analysis for STAT6.

Diagnostic cytopathology
2025

Endobronchial solitary fibrous tumor: A case report with comprehensive literature review.

International journal of surgery case reports
2025

Alveolar solitary fibrous tumor: an uncommon morphological form.

Diagnostic pathology
2025

Solitary Fibrous Tumor in the Orbit: A Rare Occurrence.

Cureus
2025

Solitary fibrous tumor of the spine.

Surgical neurology international
2025

Solitary fibrous tumor with bone metastasis: case report.

Journal of surgical case reports
2025

Hybrid Management of Giant Solitary Intracranial Fibrous Tumors: A Report of Two Cases.

Cureus
2025

A Case of Solitary Fibrous Tumor of the Greater Omentum Incidentally Detected during Preoperative Evaluation for Thyroid Cancer.

Surgical case reports
2025

Infrapubic Solitary Fibrous Tumor in a Young Male: What Is the Optimal Treatment?

Urology
2025

The association between WHO grading and the long-term outcomes and radiotherapy efficacy of intracranial solitary fibrous tumors.

Acta neuropathologica communications
2026

Solitary Fibrous Tumor of the Tarsus.

Ophthalmic plastic and reconstructive surgery
2025

A Case of Solitary Fibrous Tumor in the Pelvis Completely Resected Using the Hugo RAS System.

Journal of the anus, rectum and colon
2025

The Diagnosis and Treatment of Solitary Fibrous Tumor of the Parotid Gland.

Ear, nose, &amp; throat journal
2025

Recurrent Pediatric Extrapleural Solitary Fibrous Tumor of the Jaw.

Head and neck pathology
2025

Solitary Fibrous Tumor of the Oral Cavity: A Rare Entity with Immunohistochemical Profiling.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
2025

Highly Aggressive Intraparenchymal Solitary Fibrous Tumor of the Lung with Distant Metastasis: A Case Report and Review of CT and PET/CT Findings.

Reports (MDPI)
2025

Solitary fibrous tumor of the nasal septum: a case report and literature review.

Journal of surgical case reports
2025

90Y-FAPI-46 Theranostics Leads to Near-Complete Metabolic Response in 3 Patients with Solitary Fibrous Tumors.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
2025

Paraneoplastic Hypoglycaemia in a Patient With Solitary Fibrous Tumor of Pleura.

Respirology case reports
2025

Solitary Fibrous Tumor of the Right Elbow: A Case Report.

Cureus
2025

Management of choroidal solitary fibrous tumor with extraocular extension and subsequent postoperative rhegmatogenous retinal detachment.

American journal of ophthalmology case reports
2025

A rare case of a giant pulmonary solitary fibrous tumor: Diagnostic and therapeutic challenges in the absence of malignancy.

Respiratory medicine case reports
2025

The Significance of Cytoplasmic STAT6 Positivity and High p53/p16 Expression as a Novel Predictor of Histological/Clinical Malignancy in NAB2::STAT6 Fusion-Positive Orbital Solitary Fibrous Tumors.

Pathology international
2025

Clinicopathological and genetic analysis of orbital solitary fibrous tumors.

BMC ophthalmology
2025

Fourth Ventricular Solitary Fibrous Tumor: An Atypical Location for a Rare Tumor.

Neurology India
2025

A rare case of Doege-Potter syndrome: Anesthesia considerations for the surgical removal of a benign solitary lung fibrous tumor.

Saudi journal of anaesthesia
2025

Prostate-sparing conservative management of a solitary fibrous tumor of the prostate: A case report.

Urology case reports
2026

Fluorescein-Guided Removal of Thoracic Spinal Solitary Fibrous Tumor: 2-Dimensional Operative Video.

Operative neurosurgery (Hagerstown, Md.)
2025

Paraganglioma of the spermatic cord: A rare tumor with unique imaging findings and diagnostic challenges.

GHM open
2025

18F-FDG PET/CT SUVmax in pleuropulmonary solitary fibrous tumors: can it be incorporated into risk classification systems for predicting recurrence?

BMC pulmonary medicine
2025

Hybrid video-assisted thoracoscopic resection of a massive mediastinal solitary fibrous tumor: overcoming challenges: a case report.

Journal of medical case reports
2025

A systematic review and meta-analysis on the efficacy of postoperative radiotherapy after gross total resection of intracranial solitary fibrous tumors.

Scientific reports
2025

A clinical investigation of extracranial metastases in 17 cases of intracranial solitary fibrous tumors.

World journal of surgical oncology
2025

A Rare Case of Cervical Solitary Fibrous Tumor in a Pediatric Patient: Case Report and Literature Review.

NeuroSci
2025

Case Report: Doege-Potter syndrome: a giant solitary fibrous pleural tumor causing severe hypoglycemia.

Frontiers in oncology
2025

[Solitary fibrous tumor of the kidney].

Arkhiv patologii
2025

[Solitary fibrous tumor of common bile duct: case report and literature review].

Arkhiv patologii
2025

Identification of intracranial solitary fibrous tumor and atypical meningioma by multi-parameter MRI-based radiomics model.

Discover oncology
2025

A schwannoma look-alike: solitary fibrous tumor of the cauda equina. Illustrative case.

Journal of neurosurgery. Case lessons
2025

Exploring intraoperative hemorrhage and early recurrence in pelvic malignant solitary fibrotic tumors: a case report and literature review.

Frontiers in oncology
2025

Solitary fibrous tumor of the pleura: biphasic contrast-enhanced CT findings with emphasis on differential diagnosis.

Frontiers in medicine
2025

Massive Solitary Fibrous Tumor of the Hypopharynx.

Cureus
2025

A Rare Solitary Fibrous Tumor Localized in the Upper Lip: A Case Report.

Cureus
2025

Direct puncture embolization of intracranial solitary fibrous tumor with SQUID.

Neurocirugia
2025

Solitary Fibrous Tumor of the Seminal Vesicle With Entrapped Benign Glands Mimicking a Mixed Epithelial and Stromal Tumor: A Case Report With Literature Review.

International journal of surgical pathology
2025

Neuroendoscopic Anterior Prelacrimal Recess Approach for Resection of Tumors in the Infratemporal Fossa.

The Journal of craniofacial surgery
2025

Metastatic Breast Cancer to a Dedifferentiated Solitary Fibrous Tumor Arising from a PTEN Hamartoma of Soft Tissue.

International journal of surgical pathology
2025

Solitary fibrous tumors from A to Z: a pictorial review with radiologic-pathologic correlation.

Insights into imaging
2025

Case Report: Retroperitoneal dedifferentiated solitary fibrous tumor with unexpected Pax-2 expression, mimicking high grade clear cell renal cell carcinoma.

Frontiers in oncology
2025

Dedifferentiated Solitary Fibrous Tumor: A Clinicopathologic, Immunohistochemical, and Molecular Characterization of 25 Cases.

The American journal of surgical pathology
2025

Solitary fibrous tumors of the infratemporal fossa: case series.

Journal of surgical case reports
2026

Differential diagnosis of intracranial solitary fibrous tumor and high-grade meningioma based on CT and MRI features.

The neuroradiology journal
2025

Solitary fibrous tumor in the pterygopalatine fossa: a rare case report and literature review.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
2025

A Case of Intracranial Solitary Fibrous Tumor Followed by Distant Metastasis without Local Recurrence.

NMC case report journal
2025

Conjunctival Solitary Fibrous Tumor Masquerading as Conjunctival Hemangioma: A Case Report.

Journal of pediatric ophthalmology and strabismus
2025

Meningeal malignant solitary fibrous tumor with multiple recurrence, extracranial extension, cervical lymph node metastases: case report and review of the literature.

Discover oncology
2025

Malignant solitary fibrous tumor of the seminal vesicle: a case report and review of the literature.

BMC urology
2025

Malignant solitary fibrous tumor in the anterior abdominal wall: a rare case report with diagnostic and therapeutic insights.

Journal of surgical case reports
2025

Adverse Outcome of a Solitary Fibrous Tumor Originating in the Bladder.

IJU case reports
2025

Application of 18F-FDGPET/CT in primary isolated pulmonary solitary fibrous tumor.

Frontiers in medicine
2025

A Rare Case of Myxoid Solitary Fibrous Tumor of the Upper Lip: The Key Role of STAT6 in Diagnosis.

Cureus
2025

Low-grade intracranial solitary fibrous tumor with early metastasis to lumbar spine and recurrence twice: case report.

Discover oncology
2025

[Doege-Potter syndrome and intra-abdominal giant solitary fibrous tumor: Case report].

Revista medica del Instituto Mexicano del Seguro Social
2025

Laparoscopic Minimally Invasive Approach for Pelvic Solitary Fibrous Tumor.

Annals of surgical oncology
2025

Rare Benign Liver Tumors: Current Insights and Imaging Challenges.

Seminars in ultrasound, CT, and MR
2025

Spindle lesions in the thyroid: a cytological and histological review.

Virchows Archiv : an international journal of pathology
2025

Solitary fibrous tumor-meningioma collision tumor with 18 years of follow-up.

Journal of neuropathology and experimental neurology
2025

A Woman With Persistent Abdominal Pain in the Setting of a Solitary Fibrous Adrenal Tumor.

AACE clinical case reports
2025

Machine Learning Analysis of Single-Voxel Proton MR Spectroscopy for Differentiating Solitary Fibrous Tumors and Meningiomas.

NMR in biomedicine
2025

Seizures caused by a solitary fibrous tumour of the pleura: an unusual presentation of Doege-Potter syndrome.

BMJ case reports
2025

[Hypoglycemia in a patient with pleural solitary fibrous tumor and response to pasireotide].

Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina)
2025

Unveiling the Enigma: Gigantic primary de novo poorly-differentiated ductal adenocarcinoma of the lacrimal gland with aggressive features. A case report and literature review.

Archivos de la Sociedad Espanola de Oftalmologia
2025

Intermediate metastatic risk lipomatous solitary fibrous tumor of the thigh (previously known as hemangiopericytoma): A rare case report with a literature review.

Medicine
2025

Apparent Diffusion Coefficient (ADC) and Magnetic Resonance Imaging (MRI) Nomogram for Differentiating a Solitary Fibrous Tumor (World Health Organization Grade II) From an Angiomatous Meningioma.

Cureus
2025

Quantification of the immunohistochemical staining of fibroblast activation protein in intrathoracic solitary fibrous tumors using QuPath.

Surgery today
2025

A novel rotation and scale-invariant deep learning framework leveraging conical transformers for precise differentiation between meningioma and solitary fibrous tumor.

Journal of pathology informatics
2025

Endoscopic Transnasal Transclival Removal of a Giant Hemangiopericytoma Involving the Clivus and C1-C2 Vertebrae: A Clinical Case and Literature Review.

Cureus
2025

Incidental High-Grade Sellar Solitary Fibrous Tumor Mimicking Non-Functioning Pituitary Adenoma: A Case Report and Literature Review.

The American journal of case reports
2025

Vulvar Cellular Angiofibroma With Cytologic Atypia and Sarcomatous Transformation: A Clinicopathologic Analysis.

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
2025

Solitary Fibrous Tumor of the Pleura: A Clinical Case of a Giant Malignant Tumor With Post-surgical Recurrence.

Cureus
2025

Comparison of [68Ga]Ga-Fibroblast Activation Protein Inhibitor-04 and [18F]FDG PET Imaging for Solitary Fibrous Tumor and Preliminary Application of FAP-Targeted Radiopharmaceutical Therapy.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
2025

Solitary fibrous tumor of temporal and infratemporal region: A case report and review of rare entity.

Journal of oral biology and craniofacial research
2025

A case of solitary fibrous tumor of the breast.

Medical ultrasonography
2025

Solitary fibrous tumors: radiologic features with clinical and histopathologic correlation.

Frontiers in oncology
2025

Case report: A study on disease diagnosis and treatment outcome of a case of bilateral malignant solitary fibrous tumor of the kidneys.

Frontiers in oncology
2025

Solitary fibrous tumor in the thyroid gland as an incidental finding.

Endocrinologia, diabetes y nutricion
2025

Hypo-Fractionated versus Standard Fractionation Radiotherapy in Frail and Elderly Patients with Central Nervous System Solitary Fibrous Tumors.

Oncology
Ver todos os 2.256 no EuropePMC

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Effectiveness of classification and scoring systems in solitary fibrous tumor prognosis prediction.
    Pakistan journal of medical sciences· 2026· PMID 41836829mais citado
  2. Beyond the Globe: Molecular Diagnostics of Optic Nerve, Orbital, and Adnexal Neoplasms.
    Translational vision science &amp; technology· 2026· PMID 41769942mais citado
  3. Incidentally detected multifocal calcifying fibrous tumour of the pleura: a diagnostic enigma.
    BMJ case reports· 2026· PMID 41526074mais citado
  4. Intracranial solitary fibrous tumor with myxoid features: An unusual presentation.
    Journal of neuropathology and experimental neurology· 2026· PMID 41790571mais citado
  5. A case of orbital solitary fibrous tumor with fast-growing budding morphology.
    Orbit (Amsterdam, Netherlands)· 2026· PMID 41870983mais citado
  6. Primary thoracic synovial sarcoma in a 45-year-old male: A case report and literature review.
    Oncol Lett· 2026· PMID 41994230recente
  7. Perioperative Decision-Making for a Solitary Fibrous Tumor of the Pleura: Lessons from Two Cases and Current Evidence.
    Diagnostics (Basel)· 2026· PMID 41975771recente
  8. [Moderate to high-risk primary malignant solitary fibrous tumor of the kidney: a clinicopathological and molecular analysis of five cases].
    Zhonghua Bing Li Xue Za Zhi· 2026· PMID 41956742recente
  9. Neurosarcoidosis mimicking multiple meningiomas: illustrative case.
    J Neurosurg Case Lessons· 2026· PMID 41941841recente
  10. Long-term control of grade 3 intracranial solitary fibrous tumor achieved with pazopanib and stereotactic radiotherapy: illustrative case.
    J Neurosurg Case Lessons· 2026· PMID 41941836recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:2126(Orphanet)
  2. MONDO:0016238(MONDO)
  3. GARD:15014(GARD (NIH))
  4. Variantes catalogadas(ClinVar)
  5. Busca completa no PubMed(PubMed)
  6. Artigo Wikipedia(Wikipedia)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Tumor fibroso solitário
Compêndio · Raras BR

Tumor fibroso solitário

ORPHA:2126 · MONDO:0016238
Prevalência
Unknown
Herança
Not applicable
CID-10
D21.9 · Neoplasia benigna do tecido conjuntivo e outros tecidos moles, sem outra especificação
Ensaios
3 ativos
Medicamentos
5 registrados
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0018922
EuropePMC
Wikipedia
Papers 10a
Evidência
🥉 Relato de caso
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