Raras
Buscar doenças, sintomas, genes...
Botulismo
ORPHA:1267CID-10 · A05.1CID-11 · 1A11DOENÇA RARA

Infecção bacteriana grave causada pela toxina botulínica produzida pelo Clostridium botulinum. Os pacientes são infectados geralmente pela ingestão de alimentos contaminados ou pela contaminação de feridas. Isso leva à paralisia muscular que pode resultar em insuficiência respiratória.

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Introdução

O que você precisa saber de cara

📋

Infecção bacteriana grave causada pela toxina botulínica produzida pelo Clostridium botulinum. Os pacientes são infectados geralmente pela ingestão de alimentos contaminados ou pela contaminação de feridas. Isso leva à paralisia muscular que pode resultar em insuficiência respiratória.

Pesquisas ativas
2 ensaios
24 total registrados no ClinicalTrials.gov
Publicações científicas
4.018 artigos
Último publicado: 2026

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
<1 / 1 000 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: A05.1
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Do básico ao detalhe, leia no seu ritmo

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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🫃
Digestivo
6 sintomas
💪
Músculos
4 sintomas
❤️
Coração
3 sintomas
🧠
Neurológico
3 sintomas
🫁
Pulmão
2 sintomas
👁️
Olhos
2 sintomas

+ 25 sintomas em outras categorias

Características mais comuns

90%prev.
Disfagia
Muito frequente (99-80%)
90%prev.
Flacidez muscular
Muito frequente (99-80%)
90%prev.
Disartria
Muito frequente (99-80%)
90%prev.
Fadiga
Muito frequente (99-80%)
90%prev.
Paralisia diafragmática
Muito frequente (99-80%)
90%prev.
Paralisia de nervo craniano
Muito frequente (99-80%)
47sintomas
Muito frequente (11)
Frequente (5)
Ocasional (2)
Sem dados (29)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 47 características clínicas mais associadas, ordenadas por frequência.

DisfagiaDysphagia
Muito frequente (99-80%)90%
Flacidez muscularMuscle flaccidity
Muito frequente (99-80%)90%
DisartriaDysarthria
Muito frequente (99-80%)90%
FadigaFatigue
Muito frequente (99-80%)90%
Paralisia diafragmáticaDiaphragmatic paralysis
Muito frequente (99-80%)90%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico4.018PubMed
Últimos 10 anos200publicações
Pico2025115 papers
Linha do tempo
2026Hoje · 2026🧪 1998Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

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Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

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Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
Aprovado1
3Fase 32
2Fase 25
1Fase 14
·Pré-clínico6
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 18 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Botulismo

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

1 pesquisa recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

24 ensaios clínicos encontrados, 2 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
1.091 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 1.091

#1

The unsung hero: ntnh gene as complementary botulism marker.

Frontiers in cellular and infection microbiology2026

Botulism is a rare but severe neurological disease caused by botulinum neurotoxins (BoNTs). Standard diagnostic methods including the mouse bioassay (SMB) and bont gene type-specific PCR, are often limited by the high genetic diversity among bont subtypes, which can lead to false-negative results. The nontoxin-nonhemagglutinin (ntnh) gene is highly conserved and exclusively co-located with the bont gene complex. Thus, this study evaluates the use of ntnh gene as a complementary diagnostic tool for botulism and assesses its association with BoNT types. The ntnh gene was detected in a prospective BoNT-diagnostic group (n=88) and a BoNT-historical group (n=54). Toxin cluster proteins were identified in GenBank and RefSeq Clostridium proteomes using MMSeqs2. ntnh gene detection reinforced positive results from SMB or bont gene tests in 26 cases (35.62% of the total confirmed cases) of foodborne and infant botulism. In two foodborne cases from the BoNT-diagnostic group, the ntnh gene was detected despite negative results from both SMB and bont gene tests, highlighting its potential to identify missed cases. An in silico analysis of 3,250 RefSeq and 2,494 GenBank annotated Clostridium proteomes was conducted. respectively. So, NTNH showed a high co-presence pattern with BoNT. Moreover, NTNH sequences were far more conserved than BoNT sequences in inter-type comparisons (67.2 vs.39.7), which highlights its applicability as a disease biomarker. The ntnh gene analysis is a valuable complementary tool enhancing the diagnosis of botulism. The study highlights the need for clear guidelines to interpret positive ntnh results when direct toxin or bont gene confirmation are negative.

#2

Enteric botulinum neurotoxins facilitate infection by Salmonella and Shigella.

Science advances2026 Feb 27

Botulism is a life-threatening disease caused by botulinum neurotoxins (BoNTs) released by Clostridium bacteria. BoNTs induce a flaccid paralysis by blocking neurotransmitter release from peripheral cholinergic neurons via soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) cleavage. The enteric nervous system (ENS) controls antimicrobial defense reactions within the intestine through neuron-released mediators. Here, we show that subclinical doses of BoNT/A and BoNT/B, which are not sufficient to cause botulism when released in the intestinal lumen, paralyze ENS neurons favoring infection by prototypic bacterial pathogens such as Salmonella enterica and Shigella flexneri. The BoNTs reduce the release of mucin, decreasing the protective barrier against bacterial infection. These findings disclose previously unrecognized functions of BoNTs and roles in intestinal infections. Moreover, they indicate that BoNTs are valuable tools for investigating the ENS neuron involvement in the intestinal defense reactions.

#3

Repetitive nerve stimulation findings in iatrogenic botulism compared with myasthenia gravis.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026 Jan 17

The widespread use of botulinum toxin has been accompanied by an increase in complications, including iatrogenic botulism (IB). This study investigated repetitive nerve stimulation (RNS) findings in IB and myasthenia gravis (MG) patients. Clinical and neurophysiological data were retrospectively reviewed in IB patients negative for both acetylcholine receptor and muscle-specific kinase antibodies, and in MG patients who were positive for either. RNS was performed on the ulnar nerve at 2, 3, 5, and 50 Hz, and on the facial and spinal accessory nerves at 2, 3, and 5 Hz. Fifteen IB and 23 MG patients were included. Compound muscle action potential (CMAP) amplitudes of the ulnar and facial nerves were lower in IB (p = 0.014, p = 0.006). A progressive decrement at low-frequency RNS occurred in 60% of IB and 17% of MG patients. At 5 Hz facial RNS, 1st-2nd (p = 0.044) and 1st-4th (p = 0.008) decrements were greater in MG, whereas the 4th-10th decrement was higher in IB (p = 0.031). Ulnar CMAP changes at 50 Hz were greater in IB (p < 0.001); nine patients showed increments > 40%, four > 60%, and one > 100%, while none of the MG patients exceeded 40%. Reduced CMAP amplitude, an incremental response at high frequency, and a progressive decrement at low frequency were more commonly encountered in IB. In MG, a U-shaped pattern at low frequency and a more pronounced decrement between the 1st and 2nd responses were noted.

#4

Unusual brain MRI findings in botulism: a case report of brainstem DWI restriction and pathophysiological implications.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026 Feb 19
#5

Multifocal costal osseous pneumatosis and osteomyelitis secondary to Clostridium botulinum in a dog.

The Canadian veterinary journal = La revue veterinaire canadienne2026 Mar

A 3-year-old castrated male German shepherd dog was presented with a 48-hour history of lethargy and anorexia. On presentation, the dog was laterally recumbent, hyperthermic, tachycardic, severely dehydrated, and exhibiting abdominal pain. Abdominal radiographs raised suspicion for splenic torsion. An exploratory laparotomy revealed a suspected splenic vein thrombosis, prompting a splenectomy and an incisional gastropexy. Computed tomography revealed multifocal osseous pneumatosis, rib abscesses, costochondral luxation, renal infarcts, suspected intramuscular thrombosis, aspiration pneumonia, and lymphadenopathy. Despite negative blood culture and peri-costal abscess cultures, Clostridium botulinum was isolated from bone marrow obtained via costochondral rib aspiration. During hospitalization, persistent non-regenerative anemia and thrombocytopenia were observed; the dog was also nonambulatory tetraparetic, worse on the right, indicating a predominantly right-sided myelopathy. After some improvement, the dog was discharged from the hospital; however, his condition progressively worsened despite treatment, leading to humane euthanasia 1 mo later. Necropsy revealed disseminated round cell tumor consistent with lymphoma. Key clinical message: Visceral organ gas accumulation or intraosseous gas in the absence of previous trauma or surgery should prompt suspicion for an anaerobic infection. To the authors' knowledge, this is the first reported case of rib pneumatosis secondary to disseminated C. botulinum in a dog. Pneumatose osseuse costale multifocale et ostéomyélite secondaires à une infection à Clostridium botulinum chez un chienUn berger allemand mâle castré de 3 ans a été présenté aux urgences pour une léthargie et une anorexie évoluant depuis 48 heures. À son arrivée, l’animal était en décubitus latéral, en hyperthermie, tachycardique, sévèrement déshydraté et présentait des douleurs abdominales. Les radiographies abdominales ont fait suspecter une torsion de la rate. Une laparotomie exploratrice a révélé une suspicion de thrombose de la veine splénique, conduisant à une splénectomie et une gastropexie incisionnelle. La tomodensitométrie a révélé une pneumatose osseuse multifocale, des abcès costaux, une luxation costochondrale, des infarctus rénaux, une suspicion de thrombose intramusculaire, une pneumonie d’aspiration et une lymphadénopathie. Malgré des hémocultures et des cultures d’abcès péricostaux négatives, Clostridium botulinum a été isolé de la moelle osseuse prélevée par ponction costo-chondrale. Durant son hospitalisation, une anémie non régénérative et une thrombocytopénie persistantes ont été observées; le chien présentait également une tétraparésie non ambulatoire, plus marquée à droite, indiquant une myélopathie prédominante à droite. Après une légère amélioration, le chien a obtenu son congé de l’hôpital; cependant, son état s’est progressivement aggravé malgré le traitement, conduisant à une euthanasie 1 mois plus tard. L’autopsie a révélé une tumeur à cellules rondes disséminée, compatible avec un lymphome.Message clinique clé :L’accumulation de gaz dans les organes viscéraux ou la présence de gaz intra-osseux en l’absence de traumatisme ou d’intervention chirurgicale préalable doivent faire suspecter une infection anaérobie. À la connaissance des auteurs, il s’agit du premier cas rapporté de pneumatose costale secondaire à une infection disséminée à C. botulinum chez un chien.(Traduit par Dr Serge Messier).

Publicações recentes

Ver todas no PubMed

📚 EuropePMC2.536 artigos no totalmostrando 196

2026

A case report of atypical type E botulism.

World journal of emergency medicine
2026

Multifocal costal osseous pneumatosis and osteomyelitis secondary to Clostridium botulinum in a dog.

The Canadian veterinary journal = La revue veterinaire canadienne
2025

[Evaluation of ventilatory muscles in infants with severe botulism].

Andes pediatrica : revista Chilena de pediatria
2026

The unsung hero: ntnh gene as complementary botulism marker.

Frontiers in cellular and infection microbiology
2026

Investigating the dual nature of Clostridium botulinum: pathogenic mechanisms and therapeutic potentials.

Le infezioni in medicina
2026

Botulinum neurotoxins: A distinct subclass of SNARE-Cleaving endopeptidases.

Anaerobe
2026

Enteric botulinum neurotoxins facilitate infection by Salmonella and Shigella.

Science advances
2026

Multistate Infant Botulism Outbreak Associated with Powdered Infant Formula.

NEJM evidence
2026

More Than Just a Floppy Baby: Maintaining High Clinical Suspicion of Infant Botulism.

Cureus
2026

Timeliness and Diagnostic Yield of Suspected Botulism Notifications in a Tertiary Medical Center in Taiwan, 2014-2024.

Journal of food protection
2026

Unusual brain MRI findings in botulism: a case report of brainstem DWI restriction and pathophysiological implications.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2026

Accidental Botulism Caused by Consumption of Vacuum-Packaged Rabbit-Head Meat.

Foodborne pathogens and disease
2026

Endemic koloa maoli (Hawaiian Duck, Anas wyvilliana ) shows preferential social associations, but not based on plumage or genetic relatedness.

bioRxiv : the preprint server for biology
2026

Diphtheria Presenting With Cranial Neuropathy: The Patch Unseen.

Cureus
2026

Infant Honey Feeding and Associating Sociodemographic and Clinical Factors: Are there risks for infant botulism in Oman?

Sultan Qaboos University medical journal
2026

Electrodiagnostic Approach to Defects of Neuromuscular Transmission.

Muscle &amp; nerve
2026

Iatrogenic botulism: a risk for botulinum toxin's medical use?

Journal of neural transmission (Vienna, Austria : 1996)
2026

A large outbreak in Argentina of type D botulism in vaccinated cattle associated with phosphorus deficiency and osteophagy.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
2026

Clostridioides difficile colonization of Twin Patients Recovering From Infant Botulism.

Anaerobe
2026

Botulism in a Dog Fed a Raw Meat-Based Diet: A Case Report.

Microorganisms
2026

Presynaptic Terminal Proteins and Nicotinic Receptors Are Depleted from Mouse Parasympathetic Ganglionic Junctions Paralysed with Botulinum Neurotoxin Type A.

Toxins
2026

Advances in Clostridial Neurotoxins: Passage of the Intestinal Barrier and Targeting of Specific Neuronal Cells.

Toxins
2025

Proteolytic Activities and Immunological Effects of Light Chains of Botulinum Neurotoxin A1, A2 and A3 Subtypes.

Toxins
2025

Adult Botulism of Unknown Source with Post-Toxin Anti-GQ1b Antibodies: Implications for Molecular Mimicry-A Case Report.

Neurology international
2026

Identification of botulism C/D in 2 dogs via polymerase chain reaction.

The Canadian veterinary journal = La revue veterinaire canadienne
2026

A rare case of non-wound tetanus mimicking botulism successfully managed in the ICU.

IDCases
2026

Repetitive nerve stimulation findings in iatrogenic botulism compared with myasthenia gravis.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2026

Machine learning-based typing of Clostridium botulinum group III by FT-IR spectroscopy.

Microbiology spectrum
2026

Botulism Sequelae: A Systematic Review.

Open forum infectious diseases
2026

Antimicrobial resistance in the Bacteroides fragilis group: National multicenter survey and Bayesian modelling study, France, 2022-2023.

Journal of global antimicrobial resistance
2025

Iatrogenic Botulism Following Cosmetic Botulinum Toxin Injection Presenting With Respiratory Distress: A Case Report.

Cureus
2026

Outbreak of equine botulism type C associated with consumption of baleage in Brazil.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
2026

The many journeys of botulinum neurotoxins and the bacteria that produce them-evolutionary, geographic, and research-related movements that have contributed to our understanding of a diverse pathogen.

Microbiology and molecular biology reviews : MMBR
2026

The global epidemiology of botulism outbreaks from open-source intelligence, 2017-2024.

The American journal of emergency medicine
2025

Molecular Typing of Clostridium botulinum Isolated from Chili Pepper Preserves During a Botulism Outbreak.

Foods (Basel, Switzerland)
2025

Formula milk: US retailers failed to remove recalled products after botulism outbreak, says FDA.

BMJ (Clinical research ed.)
2025

Foodborne Botulism Presenting With Isolated Cranial Nerve Involvement in a Young Adult.

Cureus
2025

Chronic Botulism in Humans: A Case Series.

Clinical case reports
2026

Self-Applicable Thermostable Heterogeneous Microneedle Patch for Recombinant Protein Vaccination against Botulinum Neurotoxin Serotype A.

ACS applied materials &amp; interfaces
2026

Whole-genome sequencing-based typing methods for Clostridium butyricum strains from clinical, animal, plant, and environmental sources.

Microbiology spectrum
2025

Infant Botulism: A Case Study in Integrated Clinical and Public Health Response.

Clinical case reports
2025

[Surveillance and public health at the borders: an analysis of immediate reporting events in Paraná State, Brazil (2010-2019)].

Cadernos de saude publica
2025

Whole genome sequencing of neurotoxin-producing Clostridium species in New York state to bolster epidemiological investigations and reveal patterns of diversity and distribution.

Frontiers in public health
2025

Signal mining of botulinum toxin type A adverse events based on FAERS database and its implications for the treatment of cerebral palsy.

Frontiers in human neuroscience
2026

Regional Risk Discrepancy Indicates a Slow Outbreak of Infant Botulism, Victoria, Australia.

The Pediatric infectious disease journal
2025

Iatrogenic Botulism Following Botulinum Toxin Injection in a Child With Cerebral Palsy: A Case Report.

Journal of child neurology
2026

High-resolution mass spectrometry and enzyme-linked immunosorbent assay for detection of residual botulinum concentrations in a mouse model of botulism.

Legal medicine (Tokyo, Japan)
2026

General Approach to Weakness.

Emergency medicine clinics of North America
2026

Wound botulism in an intravenous drug user.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2025

Two Cases of Severe Food-Borne Botulism: Could High-Dose Methylcobalamin Accelerate Recovery?

Cureus
2025

Elucidating the crystal structure of botulinum neurotoxin type A: a personal remembrance.

Journal of neural transmission (Vienna, Austria : 1996)
2025

Iatrogenic Botulism Following Unregulated Cosmetic Botulinum Toxin Injection.

Cureus
2025

Case Report: Botulism associated with cosmetic BoNT-A injections: respiratory failure and multidrug-resistant infection as emerging clinical challenges.

Frontiers in pharmacology
2025

Introduction to Toxins Special Issue on Botulinum Toxins: New Uses in the Treatment of Diseases (2nd Edition).

Toxins
2025

A Review of Malaria, Diphtheria, and Botulism Medication Distributions by CDC Port Health Stations From May 2006 to February 2024.

Journal of public health management and practice : JPHMP
2025

A Hospitalist's Challenge: Systemic Botulism Following a Cosmetic Injection Requiring Antitoxin Therapy and Percutaneous Endoscopic Gastrostomy (PEG).

Cureus
2025

Foodborne botulism from consumption of homemade spoiled eggs: a case series and literature review.

Frontiers in medicine
2025

Familial Cluster of Foodborne Botulism Associated with Homemade Dairy Products: A Case Series.

International medical case reports journal
2025

Phosphorylation of SNAP-25 at Ser187 is enhanced following its cleavage by Botulinum Neurotoxin Serotype A, promoting the dominant-negative effect of the resulting fragment.

PLoS pathogens
2026

Cultural Persistence of Tahnik Practice (Use of Honey) Despite Infant Botulism Risk: A Community-Based Study in Pakistan.

Journal of community health nursing
2026

Pharmacovigilance and toxicological risks associated with apitherapeutic products: a systematic overview.

Archives of toxicology
2025

Author's response: Peanut butter confirmed as the source of a case of infant botulism in the United Kingdom, 2024.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
2025

Clinical and electrophysiological features of foodborne botulism: a retrospective case series.

European review for medical and pharmacological sciences
2025

A local outbreak of iatrogenic botulism associated with cosmetic injections of botulinum neurotoxin-containing products, England, 2025.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
2025

Botulism, Lambert-Eaton Myasthenic Syndrome, and Congenital Myasthenic Syndromes.

Continuum (Minneapolis, Minn.)
2026

Brain Edema After Cosmetic Botulinum Toxin Injection: A Case Report.

Journal of emergency nursing
2025

Botulism in pregnancy: A clinical review.

Toxicon : official journal of the International Society on Toxinology
2025

Research Progress on the Detection Methods of Botulinum Neurotoxin.

Toxins
2025

Features of the First Case of Foodborne Botulism Caused by Dual-Toxin Clostridium parabotulinum Subtype A1(B5) in Spain.

Toxins
2025

Nontoxic, multi-domain botulinum neurotoxin-LCHCN as vaccines against botulism.

Vaccine
2025

Gene expression dynamics in Bacillus cereus and Bacillus subtilis treated with Thymus vulgaris and Origanum vulgare subsp. hirtum essential oils.

Frontiers in microbiology
2025

Cauda equina nerve root enhancement in adult intestinal toxemia botulism.

BMC neurology
2025

Iatrogenic botulism following botulinum toxin injection: a scoping review of clinical characteristics, risk factors, and dermal considerations.

Cutaneous and ocular toxicology
2025

Microfluidic Nanobiosensor Detection of Botulinum Neurotoxin Serotype A.

ACS omega
2025

Review of Foodborne Botulism in the UK: 2006-2024.

Foods (Basel, Switzerland)
2025

Comparative genomics of Clostridium butyricum reveals a conserved genome architecture and novel virulence-related gene clusters.

Microbial genomics
2025

Feline botulism: two decades and two reports.

Veterinary research communications
2025

Botulism in waterfowl: case report in Argentina.

Acta veterinaria Scandinavica
2025

Molecular Characterization of Clostridium botulinum Isolates from Sichuan Province, China (1990-2024).

Foodborne pathogens and disease
2025

Botulinum Neurotoxins: History, Mechanism, and Applications. A Narrative Review.

Journal of neurochemistry
2025

Peanut butter confirmed as the source in a case of infant botulism, United Kingdom, 2024.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
2025

Pathogenic bacteria in biogas plants using cattle, swine, and poultry manure.

Veterinarni medicina
2025

Foodborne Botulism Caused by Clostridium botulinum Subtype A5(b3) by Self-Packaged Vacuum Spicy Rabbit Heads.

Microorganisms
2025

Combined treatment with antitoxin and 3,4-diaminopyridine improves survival outcomes after lethal botulinum neurotoxin challenge.

Molecular medicine (Cambridge, Mass.)
2025

Corrigendum to "Case management of a patient with botulism by an intensive care nurse practitioner team" [Aust Crit Care 38 (5) (2025) 101291].

Australian critical care : official journal of the Confederation of Australian Critical Care Nurses
2025

Detection of a streptogramin A O-acetyltransferase gene (vatD) in the chromosome of Clostridium botulinum isolated from infants in the United States.

Applied and environmental microbiology
2025

Infant Botulism and Carbohydrate Blood Group Antigens: Preliminary Results from a Discordant Twin Study.

Journal of pediatrics. Clinical practice
2025

Case management of a patient with botulism by an intensive care nurse practitioner team.

Australian critical care : official journal of the Confederation of Australian Critical Care Nurses
2025

Foodborne Botulism Outbreak After Consumption of Home-Canned Cactus (Nopales) - Fresno County, California, June 2024.

MMWR. Morbidity and mortality weekly report
2025

[Food-induced Botulism - Diagnosis, treatment and course].

Fortschritte der Neurologie-Psychiatrie
2025

Dual-Toxin-Producing Clostridium botulinum Strain Isolated from a Foodborne Botulism Case in Korea: Genomic and Functional Insights.

Toxins
2025

Single Tri-Epitopic Antibodies (TeAbs) to Botulinum Neurotoxin Serotypes B, E, and F Recapitulate the Full Potency of a Combination of Three Monoclonal Antibodies in Toxin Neutralization.

Toxins
2025

Botulism type C outbreak in free-ranging wild birds in a public urban park in Ribeirão Preto, São Paulo state, Brazil.

Open veterinary journal
2025

Patient reported voice outcomes following multi-disciplinary approach to botulism toxin for spasmodic dysphonia.

Acta otorrinolaringologica espanola
2025

Overview of botulinum neurotoxin-producing clostridia in soils in France.

Microbiology spectrum
2025

A Systematic Approach to Diagnosing and Managing a Patient With Excessive Gingival Display and a Hypermobile Lip.

Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)
2025

Paralysis in Pairs: Insights From Two Cases of Infant Botulism.

Clinical pediatrics
2025

Botulinum neurotoxin A mutants with enhanced ganglioside binding show improved potency and altered ganglioside selectivity.

Communications chemistry
2025

Effect of sodium nitrite, sodium chloride, sodium erythorbate, and sodium tripolyphosphate on nontoxigenic Clostridium botulinum LNT01 and C. sporogenes in growth medium and cooked cured beef - Development and validation of critical control surface.

Food research international (Ottawa, Ont.)
2025

Validation of an Endopep-suspension immunoassay for the diagnostics of human botulism.

ALTEX
2025

A Retrospective Case Series Study of Illegal Cosmetic Iatrogenic Botulism: Outbreak Analysis and Response Lessons.

Aesthetic surgery journal
2025

Botulism Type F: Foodborne or Adult Intestinal Colonization?

Gastro hep advances
2025

Could Intravenous Immunoglobulin Be an Alternative Therapy for Treating Infant Botulism in Areas Where Human Botulism Immunoglobulin Is Not Easily Available?: Our Experience in Andalusia, Spain.

The Pediatric infectious disease journal
2025

Dysphagia and Muscle Weakness Caused by Botulinum Toxin Poisoning after Cosmetic Injection: Three Case Reports and Clinical Warnings.

Dysphagia
2025

Comparison of disc diffusion and Sensititre® Broth Microdilution methods for antimicrobial susceptibility testing of Bacteroides fragilis group clinical isolates following the French guidelines.

Anaerobe
2025

Analysis of clinical challenges and prognostic risk factors for 195 cases of iatrogenic botulism in China.

Clinical toxicology (Philadelphia, Pa.)
2025

Autonomic Dysfunction and Blood Pressure Variability in Botulinum Intoxication: A Prospective Observational Study from a Single-Center Italian Outbreak.

Toxins
2025

Effects of botulinum neurotoxin-associated proteins on cellular organelle dynamics in NRK-52E cells.

Biochemical and biophysical research communications
2025

Effectiveness of a Bivalent Recombinant Vaccine on the Production of Neutralizing Antibodies Against BoNT/C, BoNT/D, BoNT/CD e BoNT/DC in Bovines.

Vaccines
2025

Recombinant Detoxified Holotoxin as a Potent Candidate Vaccine Against Botulism.

Vaccines
2025

The Scientific Benefits of a Statewide, Standardized, Coastal Wetland Monitoring Program in Hawa'i.

Ecology and evolution
2025

Comprehensive analysis of partial confounding clinical symptoms and treatment options of botulism: a case series.

Frontiers in neurology
2025

Detoxification techniques for bacterial toxins: A pathway to effective toxoid vaccines.

Toxicon : official journal of the International Society on Toxinology
2025

Public knowledge of food poisoning, risk perception and food safety practices in Saudi Arabia: A cross-sectional survey following foodborne botulism outbreak.

Medicine
2025

Investigating Avian Neglect and Welfare Violations: Case Studies in South Korea.

Case reports in veterinary medicine
2025

Isolation of Clostridium botulinum type C from a wound in a pig.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
2025

Tracing and characterization of foodborne botulism caused by the new MLST type Clostridium botulinum A2 in Hebei province, China.

Frontiers in microbiology
2025

Subtractive genomics approach: A guide to unveiling therapeutic targets across pathogens.

Journal of microbiological methods
2025

Exploring parents' knowledge, attitudes and practices on honey and botulism in the West Bank, Palestine: a cross-sectional study.

Annals of medicine
2025

[New cases of botulism after intragastric injection of botulinum toxin].

Deutsche medizinische Wochenschrift (1946)
2025

Botulism in the Highlands: Understanding the High-Altitude Effect.

Journal of epidemiology and global health
2025

Infant Botulism in Israel: A Rare Disease That Still Exist.

The Israel Medical Association journal : IMAJ
2025

A systematic review of the avian antibody (IgY) therapeutic effects on human bacterial infections over the decade.

Antibody therapeutics
2025

An Effective Prophylactic and Therapeutic Protection Against Botulinum Type A Intoxication in Mice and Rabbits Using a Humanized Monoclonal Antibody.

Toxins
2025

Global Occurrence of Infant Botulism: 2007-2021.

Pediatrics
2025

Real-life prognosis of neurological complications of botulinum toxin: A nationwide pharmacovigilance study of adverse drug reactions reported in France between 1994 and 2020.

Annals of physical and rehabilitation medicine
2025

Genomic characterisation and traceability analysis of a Clostridium botulinum strain involved in a food poisoning incident.

BMC infectious diseases
2025

Recombinant expression of receptor binding domains of all eight subtypes of botulinum neurotoxin type A for generation of antitoxins with broad reactivity.

F1000Research
2025

Botulinum Neurotoxins as Two-Faced Janus Proteins.

Biomedicines
2025

Dry and dusty outback: infant botulism.

BMJ case reports
2025

Identifying Causative Agents of a Paretic Syndrome in Waterbirds in Southern Portugal.

Toxins
2025

Complete genome sequence of Clostridium botulinum type A strain (X58540) isolated from cattle feces.

Microbiology resource announcements
2025

Conflicting Clinical Presentation of Infection with Clostridium botulinum and Clostridium perfringens in a 5-Month-Old Infant.

Journal of pediatrics. Clinical practice
2025

Comprehensive field investigation of a large botulism outbreak, Saudi Arabia, 2024.

Journal of infection and public health
2025

Botulism: An Overlooked Cause of Bulbar Weakness in Intensive Care - A Case Report.

Case reports in neurology
2025

[The application analysis of antitoxin therapy in severe infant botulism].

Zhonghua er ke za zhi = Chinese journal of pediatrics
2025

The History of Neuromodulators in Dermatologic Surgery.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
2025

Insects as Natural Hosts, Vectors and Reservoirs of Botulinum Neurotoxin-Producing Clostridia and Their Non-Toxinogenic Counterparts: Preliminary Evidence.

Environmental microbiology
2025

An overview of biosensor advancements for detecting botulinum neurotoxins: Addressing food safety and biowarfare risks.

Analytical biochemistry
2025

Outbreak of carbofuran and bifenthrin poisoning in siblings after ingestion of contaminated food in KSA: Clinical management and public health implications.

Journal of Taibah University Medical Sciences
2025

Development of a Recombinant Fusion Vaccine Candidate Against Lethal Clostridium botulinum Neurotoxin Types A and B.

Vaccines
2024

An Outbreak of Foodborne Botulism Caused by Clostridium botulinum BoNT/A3 in Pickled Eggs - Weihai City, Shandong Province, China, July 2024.

China CDC weekly
2025

EGFP/RFP-based FRET sensors for botulinum neurotoxin A biological activity detection and methodological validation.

Analytica chimica acta
2025

Iatrogenic Botulism After Cosmetic Use of Botulinum Toxin-A: A Case Series.

Clinical case reports
2024

Passive Immunisation in the Treatment of Infectious Diseases Related to Highly Potent Bacterial Toxins.

Biomedicines
2025

Development and selection of candidate monoclonal antibodies for the detection of Clostridium botulinum neurotoxin serotype B light chain.

Protein expression and purification
2024

[Infant botulism: an underestimated problem. A review].

Terapevticheskii arkhiv
2025

Wearable Temperature Sensor Enhanced Volatilomics Technique for Swift and Convenient Detection of Latrogenic Botulism.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2024

Iatrogenic Botulism Following Botulinum Toxin Injection as an Adjunct to Abdominal Wall Reconstruction for Incisional Hernia.

Cureus
2025

SiO2/Si interferometers designed for on-site botulinum neurotoxin serotypes B and C quantification and biological activity assessment.

Biosensors &amp; bioelectronics
2024

Towards safer practices: A spotlight on foodborne botulism following the recent outbreak in Saudi Arabia in 2024.

New microbes and new infections
2024

International Proficiency Test Targeting a Large Panel of Botulinum Neurotoxin Sero- and Subtypes in Different Matrices.

Toxins
2024

Botulinum toxin injection versus lateral internal sphincterotomy for chronic anal fissure: a meta-analysis of randomized control trials.

Langenbeck's archives of surgery
2025

Type B botulism mimicking a drug-induced anticholinergic syndrome.

Journal francais d'ophtalmologie
2025

A Critical Review of Postbiotics as Promising Novel Therapeutic Agents for Clostridial Infections.

Probiotics and antimicrobial proteins
2024

Healthcare workers' knowledge and preparedness for unprecedented foodborne botulism outbreak in Saudi Arabia.

Journal of infection and public health
2024

First case of infant botulism in Sicily-case report.

Italian journal of pediatrics
2024

Elevated incidence of infant botulism in a 17-county area of the Mid-Atlantic region in the United States, 2000-2019, including association with soil types.

Applied and environmental microbiology
2024

Iatrogenic botulism after intragastric botulinum neurotoxin injections - a major outbreak.

Neurological research and practice
2024

Clostridial Infections in Cattle: A Comprehensive Review with Emphasis on Current Data Gaps in Brazil.

Animals : an open access journal from MDPI
2024

Antimicrobial susceptibility of Clostridium botulinum group III field strains isolated in Europe from animal outbreaks.

Veterinary microbiology
2024

Neurally Adjusted Ventilatory Assist to Monitor Diaphragmatic Activity in Infantile Botulism.

Pediatrics
2025

Outpatient Infant Botulism in the United States, 1976-2021.

The Journal of pediatrics
2024

["Cosmetic" iatrogenic botulism : description of 2 cases in Switzerland].

Revue medicale suisse
2025

Genomic and phenotypic polymorphism of Clostridium botulinum Group II strain Beluga through laboratory domestication.

International journal of food microbiology
2025

New Engineered-Chimeric Botulinum Neurotoxin Mutant Acts as an Effective Bivalent Vaccine Against Botulinum Neurotoxin Serotype A and E.

Immunology
2024

Neurotoxin-Derived Optical Probes for Elucidating Molecular and Developmental Biology of Neurons and Synaptic Connections : Toxin-Derived Optical Probes for Neuroimaging.

Molecular imaging and biology
2024

Opportunistic Features of Non-Clostridium botulinum Strains Containing bont Gene Cluster.

Pathogens (Basel, Switzerland)
2024

Neurocognitive deficits after botulism: a clinical case series study.

Frontiers in neurology
2024

Novel platform for engineering stable and effective vaccines against botulinum neurotoxins A, B and E.

Frontiers in immunology
2024

Neutralizing chimeric heavy-chain antibody targeting the L-HN domain of Clostridium botulinum neurotoxin type F.

Archives of toxicology
2024

An early scoring system to predict mechanical ventilation for botulism: a single-center-based study.

World journal of emergency medicine
2024

Diagnosis of botulism in mammals aided by toxin ELISA and C and D gene RT-PCRs with an emphasis on farm animals.

Veterinary research communications
2024

Role of Food Safety Regulations in Protecting Public Health.

Indian journal of microbiology
2024

Unusual Presentation of Propionic Acidemia Mimicking Botulism in an Infant: A Case Report and Literature Review.

Cureus
2024

Alpha-1 antitrypsin inhibits Clostridium botulinum C2 toxin, Corynebacterium diphtheriae diphtheria toxin and B. anthracis fusion toxin.

Scientific reports
2024

Neutralization mechanism of human monoclonal antibodies against type B botulinum neurotoxin.

Microbiology and immunology
2024

Management of fulminant botulism after allogeneic hematopoietic cell transplantation.

Pediatric blood &amp; cancer
2024

From Botox Party to Botulism: A Case Report and Public Health Warning on Adulterated Botulinum Toxin Injection.

Cureus
2024

Potency Evaluations of Recombinant Botulinum Neurotoxin A1 Mutants Designed to Reduce Toxicity.

International journal of molecular sciences
2024

Ecology and Management of a Large Outbreak of Avian Botulism in Wild Waterbirds in Northeastern Italy (2019-2022).

Animals : an open access journal from MDPI
2024

Prevalence of Clostridium botulinum in Retail Peanut Butters from a 2007 Survey in Ottawa, Canada.

Current microbiology
2024

Use of Open-Source Epidemic Intelligence for Infectious Disease Outbreaks, Ukraine, 2022.

Emerging infectious diseases
2024

Tirbanibulin (KX2-391) analog KX2-361 inhibits botulinum neurotoxin serotype A mediated SNAP-25 cleavage in pre- and post-intoxication models in cells.

Drug development research
2024

Self-Administered Botulinum Injection Causing Rare Masquerade of Systemic Botulism.

Cureus
2024

Infant Botulism: In Search of Clostridium botulinum Spores.

Current microbiology
2024

Immunogenicity of a pentavalent recombinant Escherichiacoli bacterin against enterotoxemia and botulism in sheep.

Anaerobe
2024

The enemy at the gate: Botulism.

Turkish journal of emergency medicine
2024

New approach to generating of human monoclonal antibodies specific to the proteolytic domain of botulinum neurotoxin A.

BioImpacts : BI
2024

Collaborative wildlife disease outbreak investigation and response at Bells Swamp Victoria, February 2023.

Australian veterinary journal
2024

An outbreak of botulism on a pig farm due to the newly described Clostridium botulinum type C.

Anaerobe
2024

Selection of Candidate Monoclonal Antibodies for Therapy of Botulinum Toxin Type A Intoxications.

Toxins
2024

Foodborne Botulism Type F: A Rare Presentation of Neurologic Manifestation and Successful Management.

Cureus
2024

Fecal Microbiota Transplantation for Severe Infant Botulism, China.

Emerging infectious diseases
2024

Overview of anaerobic infections in children and their treatment.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
2024

The Degradation of Botulinum Neurotoxin Light Chains Using PROTACs.

International journal of molecular sciences
Ver todos os 2.536 no EuropePMC

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. The unsung hero: ntnh gene as complementary botulism marker.
    Frontiers in cellular and infection microbiology· 2026· PMID 41809992mais citado
  2. Enteric botulinum neurotoxins facilitate infection by Salmonella and Shigella.
    Science advances· 2026· PMID 41739930mais citado
  3. Repetitive nerve stimulation findings in iatrogenic botulism compared with myasthenia gravis.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology· 2026· PMID 41546732mais citado
  4. Unusual brain MRI findings in botulism: a case report of brainstem DWI restriction and pathophysiological implications.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology· 2026· PMID 41708808mais citado
  5. Multifocal costal osseous pneumatosis and osteomyelitis secondary to Clostridium botulinum in a dog.
    The Canadian veterinary journal = La revue veterinaire canadienne· 2026· PMID 41847488mais citado
  6. Wound Botulism Complicating a Snake Bite Wound Following Traditional Application of Raw Goat Skin Successfully Treated with Botulinum Antitoxin: A Case Report.
    Int Med Case Rep J· 2026· PMID 41978657recente
  7. Infant Botulism and Honey Exposure: Global Epidemiology, Prevention Policies, and Communication Strategies.
    Acta Paediatr· 2026· PMID 41964486recente
  8. Genomic Characterization of Clostridium botulinum Isolates from Soil and Soybean Samples in High-Incidence Regions - Xinjiang, Inner Mongolia, and Qinghai PLADs, China, 2024.
    China CDC Wkly· 2026· PMID 41958893recente
  9. Sudoscan as tool to detect cholinergic dysautonomia in paucisymptomatic botulism.
    Clin Neurophysiol· 2026· PMID 41955882recente
  10. Iatrogenic botulism following cosmetic botulinum toxin injection treated with delayed antitoxin therapy.
    Intern Med J· 2026· PMID 41947524recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:1267(Orphanet)
  2. MONDO:0005498(MONDO)
  3. GARD:943(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q154865(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Botulismo
Compêndio · Raras BR

Botulismo

ORPHA:1267 · MONDO:0005498
Prevalência
<1 / 1 000 000
Herança
Not applicable
CID-10
A05.1 · Botulismo
CID-11
Ensaios
2 ativos
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0006057
EuropePMC
Wikidata
Wikipedia
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