Um tumor na glândula hipófise (também conhecida como pituitária), que pode ser benigno (não canceroso) ou maligno (canceroso). A grande maioria são adenomas, tumores geralmente benignos que se desenvolvem na parte da frente dessa glândula.
Introdução
O que você precisa saber de cara
Adenoma pituitário isolado familiar (FIPA) é uma condição herdada caracterizada pelo desenvolvimento de um tumor não canceroso na glândula pituitária (chamado adenoma pituitário). A glândula pituitária, que se encontra na base do cérebro, produz hormônios que controlam muitas funções importantes do corpo.
Tumores que se formam na glândula pituitária podem liberar níveis excessivos de um ou mais hormônios, embora alguns tumores não produzam hormônios (adenomas pituitários não funcionais). Aqueles que produzem hormônios são tipicamente diferenciados pelos hormônios específicos que liberam. Prolactinomas são os tumores mais comuns em FIPA. Esses tumores liberam prolactina, um hormônio que estimula a produção de leite materno em mulheres. Tanto mulheres quanto homens podem desenvolver prolactinomas, embora sejam mais comuns em mulheres. Em mulheres, esses tumores podem levar a alterações no ciclo menstrual ou dificuldade para engravidar. Algumas mulheres afetadas podem produzir leite materno, mesmo que não estejam grávidas ou amamentando. Em homens, prolactinomas podem causar disfunção erétil ou diminuição do interesse sexual. Raramente, homens afetados produzem leite materno. Prolactinomas grandes podem pressionar tecidos próximos, como os nervos que transportam informações dos olhos para o cérebro (os nervos ópticos), causando problemas de visão.
Outro tipo de tumor chamado somatotropinoma também é comum em FIPA. Esses tumores liberam hormônio do crescimento (também chamado somatotropina), que promove o crescimento do corpo. Somatotropinomas em crianças ou adolescentes podem levar ao aumento da altura (gigantismo), porque os ossos longos dos braços e das pernas ainda estão em crescimento. Em adultos, o crescimento dos ossos longos cessou, mas os tumores podem causar crescimento excessivo das mãos, dos pés e do rosto (acromegalia), bem como de outros tecidos.
Tipos de tumor menos comuns em FIPA incluem somatolactotropinomas, adenomas pituitários não funcionais, tumores que secretam hormônio adrenocorticotrófico (que causam uma condição conhecida como doença de Cushing), tireotropinomas e gonadotropinomas. Em uma família com a condição, os membros afetados podem desenvolver o mesmo tipo de tumor (FIPA homogênea) ou tipos diferentes (FIPA heterogênea).
Em FIPA, os tumores pituitários geralmente ocorrem em idade mais jovem do que os adenomas pituitários esporádicos, que não são herdados. Em geral, os tumores de FIPA também são maiores que os tumores pituitários esporádicos. Frequentemente, pessoas com FIPA têm macroadenomas, que são tumores maiores que 10 milímetros.
Adenomas pituitários familiares podem ocorrer como uma das muitas características em outras condições herdadas, como neoplasia endócrina múltipla tipo 1 e complexo de Carney; porém, em FIPA, os adenomas pituitários são descritos como isolados porque apenas a glândula pituitária é afetada.
Fonte: MedlinePlus Genetics (NLM/NIH), traduzidoUm tumor na glândula hipófise (também conhecida como pituitária), que pode ser benigno (não canceroso) ou maligno (canceroso). A grande maioria são adenomas, tumores geralmente benignos que se desenvolvem na parte da frente dessa glândula.
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 103 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 249 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
11 genes identificados com associação a esta condição.
Deafness, autosomal dominant, 85
A form of non-syndromic, sensorineural hearing loss. Sensorineural hearing loss results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA85 is characterized by progressive hearing loss, with onset in childhood or young adulthood.
Glucocorticoid resistance, generalized
An autosomal dominant disease characterized by increased plasma cortisol concentration and high urinary free cortisol, resistance to adrenal suppression by dexamethasone, and the absence of Cushing syndrome typical signs. Clinical features include hypoglycemia, hypertension, metabolic alkalosis, chronic fatigue and profound anxiety.
Alpha-thalassemia/impaired intellectual development syndrome, X-linked
A disorder characterized by severe psychomotor retardation, facial dysmorphism, urogenital abnormalities, and alpha-thalassemia. An essential phenotypic trait are hemoglobin H erythrocyte inclusions.
Usher syndrome 1D
USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness.
Familial multiple endocrine neoplasia type I
Autosomal dominant disorder characterized by tumors of the parathyroid glands, gastro-intestinal endocrine tissue, the anterior pituitary and other tissues. Cutaneous lesions and nervous-tissue tumors can exist. Prognosis in MEN1 patients is related to hormonal hypersecretion by tumors, such as hypergastrinemia causing severe peptic ulcer disease (Zollinger-Ellison syndrome, ZES), primary hyperparathyroidism, and acute forms of hyperinsulinemia.
Pituitary adenoma 4, ACTH-secreting
A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete. PITA4 results in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes.
Pituitary adenoma 2, growth hormone-secreting
A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete. PITA2 is a growth hormone-secreting benign neoplasm, also known as somatotropinoma. It clinically results in acromegaly, a condition characterized by coarse facial features, protruding jaw, and enlarged extremities. Excessive production of growth hormone in children or adolescents before the closure of epiphyses causes gigantism, a condition characterized by abnormally tall stature.
Medicamentos e terapias
Mecanismo: Dopamine D2 receptor agonist
Mecanismo: Somatostatin receptor 5 agonist
Mecanismo: Folate receptor alpha inhibitor
Mecanismo: Somatostatin receptor 5 agonist
Mecanismo: Adrenergic receptor alpha-2 agonist
Mecanismo: Somatostatin receptor 2 agonist
Mecanismo: Receptor protein-tyrosine kinase erbB-2 inhibitor
Mecanismo: Cytotoxic T-lymphocyte protein 4 inhibitor
Mecanismo: Programmed cell death protein 1 inhibitor
Mecanismo: Somatostatin receptor agonist
Variantes genéticas (ClinVar)
832 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 1 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
79 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Tumor hipofisário
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Outros ensaios clínicos
193 ensaios clínicos encontrados, 49 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 1.650
5-Aza-Cytidine Enhances Terminal Polyadenylation Site Usage for Full-Length Transcripts in Cells.
Aqui está o resumo focado na relevância para pacientes e médicos: O 5-aza-citidina (5-azaC), uma droga anticâncer, demonstrou em células de tumor pituitário (e outras células cancerosas) promover a produção de versões mais longas e completas de mensagens genéticas (mRNAs). Isso significa que a droga estimula as células tumorais a criarem instruções genéticas inteiras, em vez de versões mais curtas que poderiam estar alteradas. Essa descoberta revela um novo mecanismo de ação do 5-azaC e sugere que essa alteração na leitura dos genes pode ser crucial para sua eficácia no tratamento de diversos tipos de câncer, incluindo tumores da hipófise.
🇧🇷 traduzidoPreclinical pharmacology and toxicology study of an AAV8-tATP7B vector for Wilson's disease.
Este estudo descreveu o desenvolvimento de uma nova terapia genética para a Doença de Wilson, uma condição causada por mutações no gene ATP7B, utilizando um vetor viral (AAV8-tATP7B) que entrega uma versão modificada do gene. Em modelos animais, a terapia demonstrou ser eficaz ao restaurar o metabolismo do cobre e a função hepática, revertendo inclusive danos hepáticos existentes. Além disso, os testes de segurança em animais revelaram um perfil de toxicidade favorável, com apenas alterações reversíveis no fígado em doses elevadas, indicando um bom potencial para futuros ensaios clínicos em pacientes.
🇧🇷 traduzidoDRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut.
Este estudo inovador revela que a deficiência da proteína DRD2 subjaz ao adenoma de hipófise, facilitando a translocação da bactéria *Escherichia coli* do intestino para a glândula. Uma vez na hipófise, a *E. coli* é fagocitada pelas micróglias, ativando uma via inflamatória que promove o crescimento tumoral. Isso sugere novas abordagens terapêuticas para pacientes com adenoma de hipófise, incluindo o uso de antimicrobianos, modulação de micróglias ou inibidores de HMGB1.
🇧🇷 traduzidoPreoperative Metabolic Predictors of Granulation Subtypes in Somatotroph Tumors: A Multicenter Retrospective Cohort Study.
Este estudo multicêntrico investigou se o índice TG-UA (triglicerídeos e ácido úrico) pode diferenciar subtipos de tumores somatotróficos (SGSTs e DGSTs) antes da cirurgia, algo atualmente possível apenas no pós-operatório. Os resultados mostraram que o subtipo SGST, frequentemente mais agressivo, foi associado a valores mais altos de TG, GH, IGF-1 e do índice TG-UA, sendo este último um preditor independente. Para médicos e pacientes, isso representa um biomarcador sanguíneo não invasivo e pré-operatório promissor para identificar o subtipo SGST, permitindo planejar tratamentos mais direcionados e eficazes antes da intervenção cirúrgica.
🇧🇷 traduzidoA case of primary papillary epithelial tumor of the sella with reverse polarity and paired box 8 expression.
Este artigo descreve um caso de Tumor Epitelial Papilar Primário da Sela (PPETS), um tipo raro de tumor da hipófise, que apresentou características morfológicas e imunohistoquímicas inéditas, incluindo polaridade nuclear reversa e expressão de PAX-8 e sinaptofisina. Para médicos, esta descoberta é crucial, pois expande o espectro conhecido do PPETS, auxiliando no diagnóstico diferencial preciso. Isso é fundamental para distinguir corretamente este tumor de adenomas hipofisários mais comuns ou de carcinomas metastáticos, garantindo assim que o paciente receba a abordagem e o tratamento adequados.
🇧🇷 traduzidoPublicações recentes
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Intranuclear Peripheral Overexpression of Pituitary-Tumor-Transforming Gene 1: Immunohistochemical Biomarker of Lymph Node Involvement in Testicular Seminoma.
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📖 RevisãoAssociations Between Transsphenoidal Surgery and Neuropsychiatric Disorders for Patients With Cushing's Disease.
🥇 Diretriz📚 EuropePMC1.442 artigos no totalmostrando 196
Brain tumor detection on magnetic resonance imaging scans using the artificial intelligence-based You Only Look Once algorithm.
The Journal of international medical researchNon-written guidelines in pituitary tumor surgery. The hidden curriculum.
PituitaryReal world experience with [68Ga]PentixaFor PET/CT in Primary Aldosteronism using newly developed harmonized diagnostic criteria.
Frontiers in endocrinologyApplication of a Gasket-Seal Technique Using Autogenous Bone Flap and Artificial Dura for Sellar Floor Reconstruction in Endoscopic Transnasal Pituitary Surgery.
The Journal of craniofacial surgeryUnique presentation of superficial siderosis of the central nervous system following pituitary tumor surgery: a case report and literature review.
Frontiers in neuroimagingHormonal rhythm disturbance is a potential contributor to postoperative cognitive dysfunction of pituitary tumor surgery.
Neuroendocrinology5-Aza-Cytidine Enhances Terminal Polyadenylation Site Usage for Full-Length Transcripts in Cells.
Genes to cells : devoted to molecular & cellular mechanismsHybrid Aquila optimizer-Harris Hawks optimization for CNN hyperparameter tuning in brain tumor classification.
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PituitaryPreclinical pharmacology and toxicology study of an AAV8-tATP7B vector for Wilson's disease.
Clinical and molecular hepatologyEfficacy and Safety of Pharmacologic Therapies in Acromegaly: A Systematic Literature Review and Network Meta-Analysis.
The Journal of clinical endocrinology and metabolismClonorchis sinensis promotes hepatocellular carcinoma progression via a potential PTTG1-β-catenin-c-MYC axis.
Food and waterborne parasitologyMultiple endocrine neoplasia with an atypical clinical course and a MEN1 gene variant of uncertain pathogenicity: A case report.
MedicineEndoscopic One-Nostril Transseptal Transsphenoidal Approach for Pituitary Tumors: Back to the Past-A Multi-Center Preliminary Experience and Literature Review.
CancersA Robust ConvNeXt-Based Framework for Efficient, Generalizable, and Explainable Brain Tumor Classification on MRI.
Bioengineering (Basel, Switzerland)Hypersomatotropism without concurrent diabetes mellitus in cats: 28 cases (2014-2024).
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European journal of pharmacologyManagement of endocrine disease: update on the management of pituitary apoplexy.
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Human mutationDRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Sex-related differences in healthcare utilization and costs among patients with pituitary adenomas.
PituitaryClinical characteristics associated with somatic GNAS mutations in acromegaly: a systematic review and institutional experience.
Frontiers in endocrinologyPTTG1 regulates the TGF-β/Smad pathway to promote the growth and metastasis of gastric cancer cells.
HereditasCoexistence of Resistance to Thyroid Hormone and a Thyroid Stimulating Hormone-Secreting Pituitary Adenoma.
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CNS neuroscience & therapeuticsMulti-class classification of brain tumors using optimized CNN and transfer learning techniques.
Scientific reportsDiagnosis and surgical management of a pituitary adenoma coexisting with a persistent trigeminal artery: Case report and review of the literature.
NeurocirugiaAtypical Presentation and Unexpected Resolution: The Role of Serial Cerebrospinal Fluid Analysis in Differentiating Bacterial and Viral Meningitis After Pituitary Surgery.
CureusAre PTTG1 variants associated with tumor characteristics and p53/Ki-67 expression in pituitary neuroendocrine tumors.
Frontiers in endocrinologyWidespread invasion of a giant prolactinoma via valveless venous channels: illustrative case.
Journal of neurosurgery. Case lessonsFertility and pregnancy in patients with prolactinoma.
Best practice & research. Clinical endocrinology & metabolismEndoscopic surgery for noninvasive prolactinomas: A large multicenter, single-arm, retrospective study (PRLomaSaR).
EndocrineInhibition of mitochondrial NADH:ubiquinone oxidoreductase by spinning oscillating magnetic fields causes toxicity in cancer cells.
FEBS lettersClinicopathological features and outcomes in non-functioning pituitary neuroendocrine tumors: a transcription factor-driven subtype analysis.
Journal of neuro-oncologyUBE2C/PTTG1 Regulates PANoptosis, Ferroptosis, and Autophagy to Improve Renal Ischemia-Reperfusion Injury.
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AACE endocrinology and diabetesRole of 68Ga-DOTATOC Positron Emission Tomography in Locating Pulmonary Neuroendocrine Tumor Presenting with ACTH-Dependent Cushing's Syndrome: A Case Report.
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Domestic animal endocrinologyAuthor's reply to the Letter to the Editor by M Vijayasimha "Standardizing blood pressure phenotyping in acromegaly: a practical companion to Araujo-Castro et al.".
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PituitaryEfficacy and Safety of Once-Weekly Lonapegsomatropin in Adults With Growth Hormone Deficiency: foresiGHt Trial Results.
The Journal of clinical endocrinology and metabolismProspective Observational Study of 118 Clinically Nonfunctioning Pituitary Adenomas.
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Toxicology and applied pharmacologyClinical characteristics and temporal trends of lumbar drain use in minimally invasive resection of pituitary neoplasms.
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Computational biology and chemistryEcchordosis Physaliphora: A Rare and Challenging Clinical Entity in a Patient With Acromegaly.
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HereditasDeciphering the Potential Causal and Prognostic Relationships Between Gut Microbiota and Brain Tumors: Insights from Genetics Analysis and Machine Learning.
Exploration (Beijing, China)Hypopituitarism Accompanied with Delusion: The Effects of Growth Hormone Replacement Therapy.
Internal medicine (Tokyo, Japan)A Web-Deployed, Explainable AI System for Comprehensive Brain Tumor Diagnosis.
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Journal of translational medicineOptimized deep learning for brain tumor detection: a hybrid approach with attention mechanisms and clinical explainability.
Scientific reportsA case of primary papillary epithelial tumor of the sella with reverse polarity and paired box 8 expression.
Brain tumor pathologyA novel residual network based on multidimensional attention and pinwheel convolution for brain tumor classification.
Scientific reportsA Comparative Study on Clinical Features, Surgical Outcomes, and Postoperative Complications in Pituitary Apoplexy vs. Non-Apoplexy Patients.
Annali italiani di chirurgiaEvaluating pituitary tumor management: aligning with pituitary tumor centers of excellence criteria.
PituitaryConsensus on acromegaly therapeutic outcomes: an update.
Nature reviews. EndocrinologyPredictive model for meningitis after pituitary tumor resection by endoscopic nasal trans-sphenoidal sinus approach.
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The Journal of craniofacial surgeryPyramidal attention-based T network for brain tumor classification: a comprehensive analysis of transfer learning approaches for clinically reliable and reliable AI hybrid approaches.
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Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes AssociationPerformance Evaluation of Artificial Intelligence Techniques in the Diagnosis of Brain Tumors: A Systematic Review and Meta-Analysis.
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Neuro-oncology advancesEffects of Total Intravenous Anesthesia and Inhalational Anesthesia on Postoperative Recovery in Patients Undergoing Transsphenoidal Pituitary Surgery:A Systematic Review.
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae SinicaeA 62-Year-Old Man With New-Onset Hypertrophic Cardiomyopathy 25 Years After Surgical Remission of Acromegaly.
Case reports in endocrinologyDevelopment of a Minimum Dataset for the Global Monitoring of the Safety and Efficacy of Growth Hormone Replacement in Adults With Growth Hormone Deficiency (AGHD).
Clinical endocrinologyRu(II)-Photodynamic Therapy Suppresses Nonfunctioning Pituitary Adenoma Growth by Targeting PI3K/AKT/p53 Signaling.
ACS applied bio materialsPituitary Apoplexy in a Cat With Presumed Acute Diabetes Insipidus.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Comparison of Clinical Outcomes between Microscopic and Endoscopic Transsphenoidal Pituitary Tumor Resection.
Journal of neurological surgery. Part B, Skull baseManagement of Osilodrostat Therapy in Patients With Cushing's Syndrome: A Modified Delphi Consensus Panel.
Journal of the Endocrine SocietyProgression of potentially aggressive pituitary neuroendocrine tumors after radiotherapy: risk factors, management, and outcomes.
European journal of endocrinologyCase Report: Pituitary metastasis from prostate adenocarcinoma: an integrated diagnosis via 68Ga-PSMA PET/CT and methylome analysis.
Frontiers in medicineFactors affecting disease control after pituitary tumor resection in acromegaly: What is the current evidence?
World journal of radiologyhe Dark Corner of the Pituitary Gland: A Case Report and Literature Review of Primary Melanocytoma.
Current medical imagingImage-based detection of the internal carotid arteries and sella turcica in endoscopic endonasal transsphenoidal surgery.
Neurosurgical focusEndoscopic endonasal surgery using indocyanine green fluorescence endoscope for Cushing's disease caused by mixed intrasellar gangliocytoma and adrenocorticotropin adenoma: illustrative case.
Journal of neurosurgery. Case lessonsReduction of polycystic kidney and liver volumes in a patient with tolvaptan-resistant autosomal dominant polycystic kidney disease and acromegaly during lanreotide therapy.
CEN case reportsHospital procedural volume is inversely linearly associated with complications in endoscopic endonasal transsphenoidal resection of pituitary tumors.
Journal of neurosurgeryEffects of lanreotide autogel immediately after a single injection for thyrotropin-producing pituitary tumor.
Endocrinology, diabetes & metabolism case reports[Application of autologous pedicled nasal mucosal flaps by "three-step" strategy in repairing of cerebrospinal fluid leakage following transsphenoidal pituitary adenoma surgery].
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgeryHypersomatotropism and Hypercortisolism Caused by a Plurihormonal Pituitary Adenoma in a Dog.
Journal of veterinary internal medicineDiagnostic strategies for central adrenal insufficiency in clinical practice: authors' response.
European journal of endocrinologyAdvances in Drug Treatments for Male Patients with Prolactinomas.
NeuroendocrinologyPresumed nonadaptation to a multifocal intraocular lens masking visual loss from a pituitary tumor.
American journal of ophthalmology case reportsPituitary tumor-transforming gene 1 and endocrine cancers: an up-to-date review through history, current insights and future perspectives.
Endocrine-related cancerPituitary Apoplexy Following Gonadotropin-Releasing Hormone Agonist Therapy: A Rare and Life-Threatening Complication.
CureusA Pituitary Macroadenoma Cosecreting Prolactin and Growth Hormone in a Patient With Multiple Endocrine Neoplasia Type 4.
JCEM case reportsThe effect of hyperprolactinemia and its treatment on oxidative stress.
Endocrine researchAir Pollution and Pituitary Adenoma Pathogenesis: Unraveling Environmental Impacts on Neuroendocrine Function and Tumorigenesis.
Journal of xenobioticsAdvanced Magnetic Resonance Imaging Techniques for Localization of a Small Thyrotropin-Secreting Pituitary Tumor.
JCEM case reportsTargeting FSHR is a highly promising strategy for improving cognitive impairment in postmenopausal women.
Molecular psychiatryAnesthetic Considerations for the Transsphenoidal Resection of a Pituitary Tumor in an Acromegalic Patient: A Case Report.
CureusSurgery for the treatment of arterial hypertension in patients with unilateral adrenal incidentalomas and mild autonomous cortisol secretion (CHIRACIC): a multicentre, open-label, superiority randomised controlled trial.
The lancet. Diabetes & endocrinologyThe impact of pituitary adenomas on cognitive performance: a systematic review.
Frontiers in endocrinologyCombined 6th and 12th Cranial Nerve Palsies (Godtfredsen Syndrome) due to Clival Lesions.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology SocietyAssociation of coagulation-related indicators with postoperative venous thromboembolism occurrence in patients with pituitary tumors.
Scientific reportsRecent Advances in Ionic Mechanisms in Pituitary Cells: Implications for Electrophysiological and Electropharmacological Research.
Journal of clinical medicineEvidence for Pituitary Repression of the Human Growth Hormone-Related Placental Lactogen Genes and a Role for P Sequences.
International journal of molecular sciencesMicroRNA Is Downregulated in Invasive Non-Functioning Pituitary Adenomas.
International journal of molecular sciencesTargeting Autophagy for Pituitary Tumors.
CancersCocaine-Induced Apoplexy of a GH-Secreting Pituitary Tumor.
Clinical case reportsIntraoperative Diagnosis and Management of Arginine Vasopressin Disorder During Pituitary Tumor Resection via Transsphenoidal Endoscopic Navigation.
CureusThe Role of Late-Night Salivary Cortisol in the Assessment of Endocrine Remission in Patients With Cushing's Disease After Pituitary Radiotherapy.
Clinical endocrinologyAndrographolide attenuates PM2.5-induced blood-brain barrier damage via antioxidant and PI3K/AKT/mTOR/NRF2 pathways.
International immunopharmacologyImpulse Control Disorders in Patients With Hyperprolactinemia on Dopamine Agonist Therapy-How Concerned Should We Be?
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsPituitary folliculo-stellate cells modulate tumor vasculature and extracellular matrix composition in experimental lactosomatotropinomas.
Biochemical and biophysical research communicationsFactors Associated With a Higher 30-Day Hospitalization Period for Pituitary Adenoma Patients: Introducing a Novel Outcome Metric.
NeurosurgeryClinicopathological characteristics associated with the prognosis of recurrent gonadotroph tumors.
Endocrine-related cancerEnSLDe: an enhanced short-range and long-range dependent system for brain tumor classification.
Frontiers in oncologyReal-World Experience with Pasireotide-LAR in Cushing's Disease: Single-Center 12-Month Observational Study.
Journal of clinical medicineDual-Stream Contrastive Latent Learning Generative Adversarial Network for Brain Image Synthesis and Tumor Classification.
Journal of imagingNavigating prognostic strategies for GH- and PRL-secreting pituitary neuroendocrine tumors: key insights from a clinicopathological study.
Frontiers in endocrinologyMetformin induces apoptosis in pituitary-derived folliculostellate cells via the IL-6/ERK pathway.
Discover oncologyThe prevalence and predictors of Cushing disease recurrence: a 10-year experience of a pituitary tumor center of excellence.
EndocrineEvaluating the Impact of Attention Mechanisms on a Fine-Tuned Neural Network for Magnetic Resonance Imaging Tumor Classification: A Comparative Analysis.
CureusSuccessful Volume Control of Invasive Pituitary Adenoma Tumor With Pasireotide: A New Horizon for a Challenging Disease.
JCEM case reportsPulmonary Fibrosis in a Patient With a Prolactinoma on Dopamine Agonists: Coincidence or Consequence.
JCEM case reportsContemporaneous Presentation of Ocular Myasthenia Gravis With Pituitary Apoplexy: A Diagnostic Dilemma.
CureusPreoperative Prediction of Non-functional Pituitary Neuroendocrine Tumors and Posterior Pituitary Tumors Based on MRI Radiomic Features.
Journal of imaging informatics in medicineRecovery of pituitary function in patients with apoplexy immediately after surgical resection of necrotic tumors.
EndocrineThyroid-Stimulating Hormone/Growth Hormone Cosecreting Pituitary Adenoma With Normal Thyroid-Stimulating Hormone Level.
JCEM case reportsComparative analysis of the effects of microscopic vs. neuroendoscopic transsphenoidal surgery on visual and pituitary function and postoperative recurrence factors in patients with pituitary tumors.
American journal of translational researchMethodology of high-dimensional flow cytometry in monitoring immune microenvironment of pituitary neuroendocrine tumors.
Cytometry. Part B, Clinical cytometry[Abnormal elevation of growth hormone in patients with pituitary adenoma combined with cirrhosis: A case report].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciencesEndocrine manifestations of pediatric CNS tumors at diagnosis and as sequalae of treatment.
Seminars in pediatric neurologyComparison of Microscopic and Endoscopic Transsphenoidal Surgery for Pituitary Adenomas.
CureusA Corticotropin-Secreting Adenoma in the Setting of von Hippel-Lindau Disease.
JCEM case reportsMyxoedema Coma in a Medically Compliant Young Patient Presenting With Cardiogenic Shock and Requiring Cardiopulmonary Resuscitation.
CureusEmploying Squeeze-and-Excitation Architecture in a Fine-Tuned Convolutional Neural Network for Magnetic Resonance Imaging Tumor Classification.
CureusRelationship between serum CEACAM1 levels and prognosis and temozolomide chemotherapy sensitivity in patients undergoing neuroendoscopic transsphenoidal pituitary tumor resection.
Pakistan journal of pharmaceutical sciencesTranscriptomic analysis of the anti-tumor effects of leflunomide in prolactinoma.
Scientific reportsEvidence for effective suppression of INa and IK(DR) by AS2034178 (bis{2-[(4-{(4'-(2-hydroxyethoxy)-2'-methyl[1,1'-biphenyl]-3-yl)methoxy}phenyl]methyl]-3,5-dioxo-1,2,4-oxadiazolidin-4-ide} tetrahydrate), an agonist of free fatty acid receptor.
Neuroscience lettersEvaluation of pituitary tumor volume as a prognostic factor in acromegaly: A cross-sectional study in two centers.
World journal of radiologyCirculating miR-20a-5p as a biomarker associated with cabergoline responsiveness in patients with hyperprolactinemia and pituitary adenomas.
European journal of endocrinologyEctopic GHRH production: revisiting a rare cause of acromegaly.
Reviews in endocrine & metabolic disordersResistant PRL-secreting PitNET associated with breast carcinoma: a case report and literature review.
International cancer conference journalAssociações
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Doença com base genética
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Doenças relacionadas
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Perguntas frequentes
O que as famílias mais perguntam sobre esta doença — cada resposta com a fonte de onde saiu
A grande maioria dos tumores que atingem a glândula hipófise são adenomas, considerados formações benignas não cancerosas. Ainda assim, embora benignos, eles demandam atenção porque podem desregular hormônios e comprimir estruturas no cérebro.
Referências
Fontes citadas no texto, publicações do grafo e bases de dados usadas neste verbete
10 publicações do grafo RarasNet (PubMed) · 6 bases de dados. Títulos, periódicos e PMIDs vêm direto da fonte, sem intermediação de IA.
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Citar este verbete
Raras. (s.d.). Tumor hipofisário. Em Raras — Enciclopédia de Doenças Raras do Brasil. https://raras.org/doenca/tumor-hipofisario
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Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
Tumor hipofisário
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Esta página agrega dados de fontes públicas e oficiais. Dados sobre cobertura no SUS (PCDT, CEAF) são verificados ativamente por agente proativo (ver badge no infobox). Demais dados têm atribuição de fonte + data da última sincronização — clique para abrir o original.
- Doença rara (ontologia)
- fonte: Orphanet
- Identificador unificado
- fonte: MONDO
- NIH/GARD
- fonte: GARD (NIH)
- Indexação biomédica
- fonte: MeSH (NLM)
- Dado público estruturado
- fonte: Wikidata
- Moléculas estudadas na doença
- fonte: OpenTargets
- Ensaios clínicos
- fonte: ClinicalTrials.gov