Raras
Buscar doenças, sintomas, genes...
Tumor hipofisário
ORPHA:304055DOENÇA RARA

Um tumor na glândula hipófise (também conhecida como pituitária), que pode ser benigno (não canceroso) ou maligno (canceroso). A grande maioria são adenomas, tumores geralmente benignos que se desenvolvem na parte da frente dessa glândula.

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Introdução

O que você precisa saber de cara

📋

Um tumor na glândula hipófise (também conhecida como pituitária), que pode ser benigno (não canceroso) ou maligno (canceroso). A grande maioria são adenomas, tumores geralmente benignos que se desenvolvem na parte da frente dessa glândula.

Pesquisas ativas
8 ensaios
213 total registrados no ClinicalTrials.gov
Publicações científicas
4.917 artigos
Último publicado: 2026 Apr 17
Medicamentos
11 registrados
CABERGOLINE, LANREOTIDE, FARLETUZUMAB

Tem tratamento?

11 medicamentos registrados
Ver detalhes, fases e interações →
CABERGOLINELANREOTIDEFARLETUZUMABPASIREOTIDEDEXMEDETOMIDINEONZIGOLIDELAPATINIBIPILIMUMABNIVOLUMABOCTREOTIDE ACETATE
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SUS: Sem cobertura SUSScore: 0%
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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

📏
Crescimento
45 sintomas
🦴
Ossos e articulações
16 sintomas
🧠
Neurológico
15 sintomas
🧬
Pele e cabelo
12 sintomas
❤️
Coração
11 sintomas
👁️
Olhos
11 sintomas

+ 103 sintomas em outras categorias

Características mais comuns

Hiperpigmentação generalizada
Sela túrcica grande
Hiperpigmentação intraoral
Hiperplasia adrenal
Amiotrofia proximal
Fraqueza muscular
249sintomas
Sem dados (249)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 249 características clínicas mais associadas, ordenadas por frequência.

Hiperpigmentação generalizadaGeneralized hyperpigmentation
Sela túrcica grandeLarge sella turcica
Hiperpigmentação intraoralIntra-oral hyperpigmentation
Hiperplasia adrenalAdrenal hyperplasia
Amiotrofia proximalProximal amyotrophy

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico4.917PubMed
Últimos 10 anos200publicações
Pico2025147 papers
Linha do tempo
2026Hoje · 2026🧪 1979Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

Genes associados

11 genes identificados com associação a esta condição.

GNASProtein ALEXDisease-causing germline mutation(s) inAltamente restrito
FUNÇÃO

May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame

LOCALIZAÇÃO

Cell membraneCell projection, ruffle

VIAS BIOLÓGICAS (10)
G alpha (s) signalling eventsProstacyclin signalling through prostacyclin receptorADORA2B mediated anti-inflammatory cytokines productionGPER1 signalingG alpha (i) signalling events
EXPRESSÃO TECIDUAL(Ubíquo)
Pituitária
1324.4 TPM
Tireoide
727.3 TPM
Hipotálamo
548.6 TPM
Brain Frontal Cortex BA9
501.2 TPM
Cérebro - Hemisfério cerebelar
474.1 TPM
OUTRAS DOENÇAS (12)
progressive osseous heteroplasiapituitary adenoma 3, multiple typespseudohypoparathyroidism type 1CMcCune-Albright syndrome
HGNC:4392UniProt:P84996
USP48Ubiquitin carboxyl-terminal hydrolase 48Candidate gene tested inAltamente restrito
FUNÇÃO

Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of polyubiquitin precursors as well as that of ubiquitinated proteins (PubMed:16214042, PubMed:34059922). Plays a role in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Plays an important role in cell cycle progression by deubiquitinating Aurora B/AURKB an

LOCALIZAÇÃO

CytoplasmNucleusCell projection, cilium

VIAS BIOLÓGICAS (1)
Ub-specific processing proteases
MECANISMO DE DOENÇA

Deafness, autosomal dominant, 85

A form of non-syndromic, sensorineural hearing loss. Sensorineural hearing loss results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA85 is characterized by progressive hearing loss, with onset in childhood or young adulthood.

EXPRESSÃO TECIDUAL(Ubíquo)
Linfócitos
68.8 TPM
Cérebro - Hemisfério cerebelar
55.8 TPM
Cerebelo
55.3 TPM
Ovário
36.8 TPM
Glândula adrenal
35.5 TPM
OUTRAS DOENÇAS (3)
hearing loss, autosomal dominant 85autosomal dominant nonsyndromic hearing lossCushing disease due to pituitary adenoma
HGNC:18533UniProt:Q86UV5
BRAFSerine/threonine-protein kinase B-rafCandidate gene tested inAltamente restrito
FUNÇÃO

Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179)

LOCALIZAÇÃO

NucleusCytoplasmCell membrane

VIAS BIOLÓGICAS (4)
Spry regulation of FGF signalingParadoxical activation of RAF signaling by kinase inactive BRAFARMS-mediated activationSignalling to p38 via RIT and RIN
OUTRAS DOENÇAS (18)
Noonan syndrome 7LEOPARD syndrome 3melanoma, cutaneous malignant, susceptibility to, 1lung cancer
HGNC:1097UniProt:P15056
NR3C1Glucocorticoid receptorCandidate gene tested inAltamente restrito
FUNÇÃO

Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of ta

LOCALIZAÇÃO

CytoplasmNucleusMitochondrionCytoplasm, cytoskeleton, spindleCytoplasm, cytoskeleton, microtubule organizing center, centrosomeChromosomeNucleus, nucleoplasm

VIAS BIOLÓGICAS (6)
PTK6 ExpressionRegulation of RUNX2 expression and activityRegulation of NPAS4 gene transcriptionFOXO-mediated transcription of oxidative stress, metabolic and neuronal genesSUMOylation of intracellular receptors
MECANISMO DE DOENÇA

Glucocorticoid resistance, generalized

An autosomal dominant disease characterized by increased plasma cortisol concentration and high urinary free cortisol, resistance to adrenal suppression by dexamethasone, and the absence of Cushing syndrome typical signs. Clinical features include hypoglycemia, hypertension, metabolic alkalosis, chronic fatigue and profound anxiety.

EXPRESSÃO TECIDUAL(Ubíquo)
Linfócitos
55.3 TPM
Nervo tibial
34.5 TPM
Tecido adiposo
34.1 TPM
Fibroblastos
33.6 TPM
Artéria tibial
32.7 TPM
OUTRAS DOENÇAS (2)
glucocorticoid resistanceCushing disease due to pituitary adenoma
HGNC:7978UniProt:P04150
TP53Cellular tumor antigen p53Candidate gene tested inAltamente restrito
FUNÇÃO

Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apop

LOCALIZAÇÃO

CytoplasmNucleusNucleus, PML bodyEndoplasmic reticulumMitochondrion matrixCytoplasm, cytoskeleton, microtubule organizing center, centrosome

VIAS BIOLÓGICAS (10)
TP53 Regulates Metabolic GenesRegulation of TP53 ExpressionRegulation of TP53 DegradationOncogene Induced SenescenceOxidative Stress Induced Senescence
EXPRESSÃO TECIDUAL(Ubíquo)
Linfócitos
73.0 TPM
Skin Sun Exposed Lower leg
37.0 TPM
Skin Not Sun Exposed Suprapubic
35.2 TPM
Fibroblastos
32.9 TPM
Ovário
32.4 TPM
OUTRAS DOENÇAS (29)
Li-Fraumeni syndromenasopharyngeal carcinoma, susceptibility to, 1hepatocellular carcinomafamilial pancreatic carcinoma
HGNC:11998UniProt:P04637
ATRXTranscriptional regulator ATRXCandidate gene tested inAltamente restrito
FUNÇÃO

Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling

LOCALIZAÇÃO

NucleusChromosome, telomereNucleus, PML body

VIAS BIOLÓGICAS (2)
Inhibition of DNA recombination at telomereDefective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations
MECANISMO DE DOENÇA

Alpha-thalassemia/impaired intellectual development syndrome, X-linked

A disorder characterized by severe psychomotor retardation, facial dysmorphism, urogenital abnormalities, and alpha-thalassemia. An essential phenotypic trait are hemoglobin H erythrocyte inclusions.

OUTRAS DOENÇAS (5)
intellectual disability-hypotonic facies syndrome, X-linked, 1alpha-thalassemia-myelodysplastic syndromealpha thalassemia-X-linked intellectual disability syndromegastric neuroendocrine neoplasm
HGNC:886UniProt:P46100
CDH23Cadherin-23Candidate gene tested inTolerante
FUNÇÃO

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for norma

LOCALIZAÇÃO

Cell membrane

VIAS BIOLÓGICAS (2)
Sensory processing of sound by outer hair cells of the cochleaSensory processing of sound by inner hair cells of the cochlea
MECANISMO DE DOENÇA

Usher syndrome 1D

USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness.

OUTRAS DOENÇAS (12)
autosomal recessive nonsyndromic hearing loss 12Usher syndrome type 1Dnonsyndromic genetic hearing lossUsher syndrome
HGNC:13733UniProt:Q9H251
MEN1MeninCandidate gene tested inAltamente restrito
FUNÇÃO

Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates

LOCALIZAÇÃO

Nucleus

VIAS BIOLÓGICAS (4)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionDeactivation of the beta-catenin transactivating complexFormation of the beta-catenin:TCF transactivating complexFormation of WDR5-containing histone-modifying complexes
MECANISMO DE DOENÇA

Familial multiple endocrine neoplasia type I

Autosomal dominant disorder characterized by tumors of the parathyroid glands, gastro-intestinal endocrine tissue, the anterior pituitary and other tissues. Cutaneous lesions and nervous-tissue tumors can exist. Prognosis in MEN1 patients is related to hormonal hypersecretion by tumors, such as hypergastrinemia causing severe peptic ulcer disease (Zollinger-Ellison syndrome, ZES), primary hyperparathyroidism, and acute forms of hyperinsulinemia.

EXPRESSÃO TECIDUAL(Ubíquo)
Cerebelo
45.1 TPM
Tireoide
43.2 TPM
Cérebro - Hemisfério cerebelar
40.2 TPM
Fibroblastos
37.9 TPM
Baço
35.0 TPM
OUTRAS DOENÇAS (7)
multiple endocrine neoplasia type 1pituitary gigantismnull pituitary adenomaprolactin-producing pituitary gland adenoma
HGNC:7010UniProt:O00255
USP8Ubiquitin carboxyl-terminal hydrolase 8Disease-causing germline mutation(s) inAltamente restrito
FUNÇÃO

Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates t

LOCALIZAÇÃO

CytoplasmNucleusEndosome membraneCell membrane

VIAS BIOLÓGICAS (4)
Downregulation of ERBB2:ERBB3 signalingRegulation of FZD by ubiquitinationNegative regulation of MET activityUb-specific processing proteases
MECANISMO DE DOENÇA

Pituitary adenoma 4, ACTH-secreting

A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete. PITA4 results in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes.

EXPRESSÃO TECIDUAL(Ubíquo)
Fibroblastos
10.4 TPM
Linfócitos
9.2 TPM
Nervo tibial
9.1 TPM
Cervix Endocervix
8.7 TPM
Ovário
8.3 TPM
OUTRAS DOENÇAS (2)
Cushing disease due to pituitary adenomaautosomal recessive spastic paraplegia type 59
HGNC:12631UniProt:P40818
GPR101Probable G-protein coupled receptor 101Disease-causing germline mutation(s) inTolerante
FUNÇÃO

Orphan receptor

LOCALIZAÇÃO

Cell membrane

MECANISMO DE DOENÇA

Pituitary adenoma 2, growth hormone-secreting

A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete. PITA2 is a growth hormone-secreting benign neoplasm, also known as somatotropinoma. It clinically results in acromegaly, a condition characterized by coarse facial features, protruding jaw, and enlarged extremities. Excessive production of growth hormone in children or adolescents before the closure of epiphyses causes gigantism, a condition characterized by abnormally tall stature.

EXPRESSÃO TECIDUAL(Baixa expressão)
Brain Nucleus accumbens basal ganglia
4.1 TPM
Hipotálamo
0.8 TPM
Brain Caudate basal ganglia
0.8 TPM
Brain Putamen basal ganglia
0.3 TPM
Cérebro - Hemisfério cerebelar
0.2 TPM
OUTRAS DOENÇAS (2)
pituitary adenoma, growth hormone-secreting, 2acromegaly
HGNC:14963UniProt:Q96P66
AIPSmall ribosomal subunit protein bS22, mitochondrialDisease-causing germline mutation(s) inModerado
FUNÇÃO

May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation

LOCALIZAÇÃO

Mitochondrion matrixNucleus

VIAS BIOLÓGICAS (2)
Aryl hydrocarbon receptor signallingGene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
OUTRAS DOENÇAS (7)
growth hormone secreting pituitary adenoma 1familial isolated pituitary adenomapituitary gigantismsilent pituitary adenoma
HGNC:358UniProt:Q9NWT8

Medicamentos e terapias

CABERGOLINEPhase 3

Mecanismo: Dopamine D2 receptor agonist

LANREOTIDEPhase 3

Mecanismo: Somatostatin receptor 5 agonist

FARLETUZUMABPhase 2

Mecanismo: Folate receptor alpha inhibitor

PASIREOTIDEPhase 2

Mecanismo: Somatostatin receptor 5 agonist

DEXMEDETOMIDINEPhase 2

Mecanismo: Adrenergic receptor alpha-2 agonist

ONZIGOLIDEPhase 2

Mecanismo: Somatostatin receptor 2 agonist

LAPATINIBPhase 2

Mecanismo: Receptor protein-tyrosine kinase erbB-2 inhibitor

IPILIMUMABPhase 2

Mecanismo: Cytotoxic T-lymphocyte protein 4 inhibitor

NIVOLUMABPhase 2

Mecanismo: Programmed cell death protein 1 inhibitor

OCTREOTIDE ACETATEPhase 2

Mecanismo: Somatostatin receptor agonist

Ver mais no OpenTargets

Variantes genéticas (ClinVar)

832 variantes patogênicas registradas no ClinVar.

🧬 GNAS: NM_016592.5(GNAS):c.138C>A (p.Ala46=) ()
🧬 GNAS: NM_016592.5(GNAS):c.195del (p.Asn66fs) ()
🧬 GNAS: NM_000516.7(GNAS):c.177G>C (p.Gln59His) ()
🧬 GNAS: NM_000516.7(GNAS):c.-2_1del (p.Met1del) ()
🧬 GNAS: NM_000516.7(GNAS):c.516del (p.Ile172fs) ()
Ver todas no ClinVar

Classificação de variantes (ClinVar)

Distribuição de 1 variantes classificadas pelo ClinVar.

1
VUS (100.0%)
VARIANTES MAIS SIGNIFICATIVAS
GNAS: NM_000516.7(GNAS):c.601C>A (p.Arg201Ser) [Uncertain significance]

Vias biológicas (Reactome)

79 vias biológicas associadas aos genes desta condição.

GNAS1 GNAS2 GNAS G alpha (s):GTP:SRC dissociates G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC G protein alpha (s):GTP binds SRC Ub-specific processing proteases Spry regulation of FGF signaling Frs2-mediated activation ARMS-mediated activation Signalling to p38 via RIT and RIN RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Nuclear Receptor transcription pathway SUMOylation of intracellular receptors PTK6 Expression Regulation of RUNX2 expression and activity FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Potential therapeutics for SARS Regulation of NPAS4 gene transcription Activation of NOXA and translocation to mitochondria Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence DNA Damage/Telomere Stress Induced Senescence SUMOylation of transcription factors Autodegradation of the E3 ubiquitin ligase COP1 Association of TriC/CCT with target proteins during biosynthesis Pyroptosis TP53 Regulates Metabolic Genes Ovarian tumor domain proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Expression Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Regulation of TP53 Activity through Methylation Inhibition of DNA recombination at telomere Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea Formation of the beta-catenin:TCF transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Deactivation of the beta-catenin transactivating complex Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate IQGAPs Post-translational protein phosphorylation Formation of WDR5-containing histone-modifying complexes Downregulation of ERBB2:ERBB3 signaling Regulation of FZD by ubiquitination Negative regulation of MET activity Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

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Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
Aprovado1
3Fase 32
2Fase 210
·Pré-clínico7
Medicamentos catalogadosEnsaios clínicos· 10 medicamentos · 10 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Tumor hipofisário

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Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

5 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

213 ensaios clínicos encontrados, 8 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

🥇Melhor nível de evidência: Diretriz
Timeline de publicações
1.650 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 1.650

#1

5-Aza-Cytidine Enhances Terminal Polyadenylation Site Usage for Full-Length Transcripts in Cells.

Genes to cells : devoted to molecular & cellular mechanisms2026 Mar

Aqui está o resumo focado na relevância para pacientes e médicos: O 5-aza-citidina (5-azaC), uma droga anticâncer, demonstrou em células de tumor pituitário (e outras células cancerosas) promover a produção de versões mais longas e completas de mensagens genéticas (mRNAs). Isso significa que a droga estimula as células tumorais a criarem instruções genéticas inteiras, em vez de versões mais curtas que poderiam estar alteradas. Essa descoberta revela um novo mecanismo de ação do 5-azaC e sugere que essa alteração na leitura dos genes pode ser crucial para sua eficácia no tratamento de diversos tipos de câncer, incluindo tumores da hipófise.

🇧🇷 traduzido
#2

Preclinical pharmacology and toxicology study of an AAV8-tATP7B vector for Wilson's disease.

Clinical and molecular hepatology2026 Mar 04

Este estudo descreveu o desenvolvimento de uma nova terapia genética para a Doença de Wilson, uma condição causada por mutações no gene ATP7B, utilizando um vetor viral (AAV8-tATP7B) que entrega uma versão modificada do gene. Em modelos animais, a terapia demonstrou ser eficaz ao restaurar o metabolismo do cobre e a função hepática, revertendo inclusive danos hepáticos existentes. Além disso, os testes de segurança em animais revelaram um perfil de toxicidade favorável, com apenas alterações reversíveis no fígado em doses elevadas, indicando um bom potencial para futuros ensaios clínicos em pacientes.

🇧🇷 traduzido
#3

DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)2026 Feb 08

Este estudo inovador revela que a deficiência da proteína DRD2 subjaz ao adenoma de hipófise, facilitando a translocação da bactéria *Escherichia coli* do intestino para a glândula. Uma vez na hipófise, a *E. coli* é fagocitada pelas micróglias, ativando uma via inflamatória que promove o crescimento tumoral. Isso sugere novas abordagens terapêuticas para pacientes com adenoma de hipófise, incluindo o uso de antimicrobianos, modulação de micróglias ou inibidores de HMGB1.

🇧🇷 traduzido
#4

Preoperative Metabolic Predictors of Granulation Subtypes in Somatotroph Tumors: A Multicenter Retrospective Cohort Study.

CNS neuroscience & therapeutics2026 Feb

Este estudo multicêntrico investigou se o índice TG-UA (triglicerídeos e ácido úrico) pode diferenciar subtipos de tumores somatotróficos (SGSTs e DGSTs) antes da cirurgia, algo atualmente possível apenas no pós-operatório. Os resultados mostraram que o subtipo SGST, frequentemente mais agressivo, foi associado a valores mais altos de TG, GH, IGF-1 e do índice TG-UA, sendo este último um preditor independente. Para médicos e pacientes, isso representa um biomarcador sanguíneo não invasivo e pré-operatório promissor para identificar o subtipo SGST, permitindo planejar tratamentos mais direcionados e eficazes antes da intervenção cirúrgica.

🇧🇷 traduzido
#5

A case of primary papillary epithelial tumor of the sella with reverse polarity and paired box 8 expression.

Brain tumor pathology2026 Jan

Este artigo descreve um caso de Tumor Epitelial Papilar Primário da Sela (PPETS), um tipo raro de tumor da hipófise, que apresentou características morfológicas e imunohistoquímicas inéditas, incluindo polaridade nuclear reversa e expressão de PAX-8 e sinaptofisina. Para médicos, esta descoberta é crucial, pois expande o espectro conhecido do PPETS, auxiliando no diagnóstico diferencial preciso. Isso é fundamental para distinguir corretamente este tumor de adenomas hipofisários mais comuns ou de carcinomas metastáticos, garantindo assim que o paciente receba a abordagem e o tratamento adequados.

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Hybrid Aquila optimizer-Harris Hawks optimization for CNN hyperparameter tuning in brain tumor classification.

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Journal of imaging informatics in medicine
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Combined endoscopic endonasal transsphenoidal and microscopic transcranial approaches for the primary resection of giant pituitary adenomas.

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The Laryngoscope
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CNS neuroscience & therapeutics
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Update on Medical Treatment of Cushing's Syndrome.

Drugs
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Expert review of endocrinology & metabolism
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International journal of molecular sciences
2025

Paeoniflorin attenuates hyperprolactinemia by targeting the pituitary mPRα-mediated, dopamine receptor-independent signaling in vivo and in vitro.

Toxicology and applied pharmacology
2025

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World journal of otorhinolaryngology - head and neck surgery
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Computational biology and chemistry
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JCEM case reports
2025

Decoding the PTTG family's contribution to LUAD pathogenesis: a comprehensive study on expression, epigenetics, and therapeutic interventions.

Hereditas
2025

Deciphering the Potential Causal and Prognostic Relationships Between Gut Microbiota and Brain Tumors: Insights from Genetics Analysis and Machine Learning.

Exploration (Beijing, China)
2026

Hypopituitarism Accompanied with Delusion: The Effects of Growth Hormone Replacement Therapy.

Internal medicine (Tokyo, Japan)
2025

A Web-Deployed, Explainable AI System for Comprehensive Brain Tumor Diagnosis.

Neurology international
2025

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Journal of translational medicine
2025

Optimized deep learning for brain tumor detection: a hybrid approach with attention mechanisms and clinical explainability.

Scientific reports
2026

A case of primary papillary epithelial tumor of the sella with reverse polarity and paired box 8 expression.

Brain tumor pathology
2025

A novel residual network based on multidimensional attention and pinwheel convolution for brain tumor classification.

Scientific reports
2025

A Comparative Study on Clinical Features, Surgical Outcomes, and Postoperative Complications in Pituitary Apoplexy vs. Non-Apoplexy Patients.

Annali italiani di chirurgia
2025

Evaluating pituitary tumor management: aligning with pituitary tumor centers of excellence criteria.

Pituitary
2025

Consensus on acromegaly therapeutic outcomes: an update.

Nature reviews. Endocrinology
2025

Predictive model for meningitis after pituitary tumor resection by endoscopic nasal trans-sphenoidal sinus approach.

European journal of medical research
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Initial Clinical Experience Using Naked-Eye 3D 4K Exoscope for Vestibular Schwannoma.

The Journal of craniofacial surgery
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Pyramidal attention-based T network for brain tumor classification: a comprehensive analysis of transfer learning approaches for clinically reliable and reliable AI hybrid approaches.

Scientific reports
2025

Targeting Src tyrosine kinase to enhance radioiodide uptake in breast cancer.

Endocrine-related cancer
2025

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Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
2025

Performance Evaluation of Artificial Intelligence Techniques in the Diagnosis of Brain Tumors: A Systematic Review and Meta-Analysis.

Cureus
2025

Current understanding of the role of DNA methylation in pituitary neuroendocrine tumors.

Neuro-oncology advances
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Neuro-oncology advances
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2025

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Case reports in endocrinology
2025

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Clinical endocrinology
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2025

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Frontiers in medicine
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2025

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JCEM case reports
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Cureus
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Frontiers in endocrinology
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Combined 6th and 12th Cranial Nerve Palsies (Godtfredsen Syndrome) due to Clival Lesions.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
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Association of coagulation-related indicators with postoperative venous thromboembolism occurrence in patients with pituitary tumors.

Scientific reports
2025

Recent Advances in Ionic Mechanisms in Pituitary Cells: Implications for Electrophysiological and Electropharmacological Research.

Journal of clinical medicine
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International journal of molecular sciences
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MicroRNA Is Downregulated in Invasive Non-Functioning Pituitary Adenomas.

International journal of molecular sciences
2025

Targeting Autophagy for Pituitary Tumors.

Cancers
2025

Cocaine-Induced Apoplexy of a GH-Secreting Pituitary Tumor.

Clinical case reports
2025

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Cureus
2025

The Role of Late-Night Salivary Cortisol in the Assessment of Endocrine Remission in Patients With Cushing's Disease After Pituitary Radiotherapy.

Clinical endocrinology
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International immunopharmacology
2025

Impulse Control Disorders in Patients With Hyperprolactinemia on Dopamine Agonist Therapy-How Concerned Should We Be?

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
2025

Pituitary folliculo-stellate cells modulate tumor vasculature and extracellular matrix composition in experimental lactosomatotropinomas.

Biochemical and biophysical research communications
2025

Factors Associated With a Higher 30-Day Hospitalization Period for Pituitary Adenoma Patients: Introducing a Novel Outcome Metric.

Neurosurgery
2025

Clinicopathological characteristics associated with the prognosis of recurrent gonadotroph tumors.

Endocrine-related cancer
2025

EnSLDe: an enhanced short-range and long-range dependent system for brain tumor classification.

Frontiers in oncology
2025

Real-World Experience with Pasireotide-LAR in Cushing's Disease: Single-Center 12-Month Observational Study.

Journal of clinical medicine
2025

Dual-Stream Contrastive Latent Learning Generative Adversarial Network for Brain Image Synthesis and Tumor Classification.

Journal of imaging
2025

Navigating prognostic strategies for GH- and PRL-secreting pituitary neuroendocrine tumors: key insights from a clinicopathological study.

Frontiers in endocrinology
2025

Metformin induces apoptosis in pituitary-derived folliculostellate cells via the IL-6/ERK pathway.

Discover oncology
2025

The prevalence and predictors of Cushing disease recurrence: a 10-year experience of a pituitary tumor center of excellence.

Endocrine
2025

Evaluating the Impact of Attention Mechanisms on a Fine-Tuned Neural Network for Magnetic Resonance Imaging Tumor Classification: A Comparative Analysis.

Cureus
2025

Successful Volume Control of Invasive Pituitary Adenoma Tumor With Pasireotide: A New Horizon for a Challenging Disease.

JCEM case reports
2025

Pulmonary Fibrosis in a Patient With a Prolactinoma on Dopamine Agonists: Coincidence or Consequence.

JCEM case reports
2025

Contemporaneous Presentation of Ocular Myasthenia Gravis With Pituitary Apoplexy: A Diagnostic Dilemma.

Cureus
2026

Preoperative Prediction of Non-functional Pituitary Neuroendocrine Tumors and Posterior Pituitary Tumors Based on MRI Radiomic Features.

Journal of imaging informatics in medicine
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Recovery of pituitary function in patients with apoplexy immediately after surgical resection of necrotic tumors.

Endocrine
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Thyroid-Stimulating Hormone/Growth Hormone Cosecreting Pituitary Adenoma With Normal Thyroid-Stimulating Hormone Level.

JCEM case reports
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Comparative analysis of the effects of microscopic vs. neuroendoscopic transsphenoidal surgery on visual and pituitary function and postoperative recurrence factors in patients with pituitary tumors.

American journal of translational research
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Methodology of high-dimensional flow cytometry in monitoring immune microenvironment of pituitary neuroendocrine tumors.

Cytometry. Part B, Clinical cytometry
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[Abnormal elevation of growth hormone in patients with pituitary adenoma combined with cirrhosis: A case report].

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Endocrine manifestations of pediatric CNS tumors at diagnosis and as sequalae of treatment.

Seminars in pediatric neurology
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Comparison of Microscopic and Endoscopic Transsphenoidal Surgery for Pituitary Adenomas.

Cureus
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A Corticotropin-Secreting Adenoma in the Setting of von Hippel-Lindau Disease.

JCEM case reports
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Myxoedema Coma in a Medically Compliant Young Patient Presenting With Cardiogenic Shock and Requiring Cardiopulmonary Resuscitation.

Cureus
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Employing Squeeze-and-Excitation Architecture in a Fine-Tuned Convolutional Neural Network for Magnetic Resonance Imaging Tumor Classification.

Cureus
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Relationship between serum CEACAM1 levels and prognosis and temozolomide chemotherapy sensitivity in patients undergoing neuroendoscopic transsphenoidal pituitary tumor resection.

Pakistan journal of pharmaceutical sciences
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Transcriptomic analysis of the anti-tumor effects of leflunomide in prolactinoma.

Scientific reports
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Evidence for effective suppression of INa and IK(DR) by AS2034178 (bis{2-[(4-{(4'-(2-hydroxyethoxy)-2'-methyl[1,1'-biphenyl]-3-yl)methoxy}phenyl]methyl]-3,5-dioxo-1,2,4-oxadiazolidin-4-ide} tetrahydrate), an agonist of free fatty acid receptor.

Neuroscience letters
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Evaluation of pituitary tumor volume as a prognostic factor in acromegaly: A cross-sectional study in two centers.

World journal of radiology
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Circulating miR-20a-5p as a biomarker associated with cabergoline responsiveness in patients with hyperprolactinemia and pituitary adenomas.

European journal of endocrinology
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Ectopic GHRH production: revisiting a rare cause of acromegaly.

Reviews in endocrine & metabolic disorders
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Resistant PRL-secreting PitNET associated with breast carcinoma: a case report and literature review.

International cancer conference journal
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Ainda não existe comunidade no Raras para Tumor hipofisário

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Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. 5-Aza-Cytidine Enhances Terminal Polyadenylation Site Usage for Full-Length Transcripts in Cells.
    Genes to cells : devoted to molecular & cellular mechanisms· 2026· PMID 41804605mais citado
  2. Preclinical pharmacology and toxicology study of an AAV8-tATP7B vector for Wilson's disease.
    Clinical and molecular hepatology· 2026· PMID 41780554mais citado
  3. DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut.
    Advanced science (Weinheim, Baden-Wurttemberg, Germany)· 2026· PMID 41655211mais citado
  4. Preoperative Metabolic Predictors of Granulation Subtypes in Somatotroph Tumors: A Multicenter Retrospective Cohort Study.
    CNS neuroscience & therapeutics· 2026· PMID 41631367mais citado
  5. A case of primary papillary epithelial tumor of the sella with reverse polarity and paired box 8 expression.
    Brain tumor pathology· 2026· PMID 40864342mais citado
  6. Therapy for aggressive pituitary tumors and carcinomas.
    Rev Endocr Metab Disord· 2026· PMID 41995969recente
  7. Predictive model for the diagnosis of Ectopic Cushing Syndrome.
    Endocr Relat Cancer· 2026· PMID 41989874recente
  8. Intranuclear Peripheral Overexpression of Pituitary-Tumor-Transforming Gene 1: Immunohistochemical Biomarker of Lymph Node Involvement in Testicular Seminoma.
    Cancers (Basel)· 2026· PMID 41976385recente
  9. Hybrid CNN-GCN framework for brain tumor MRI classification: A graph-based approach to smart healthcare diagnostics.
    J Appl Clin Med Phys· 2026· PMID 41972366recente
  10. Associations Between Transsphenoidal Surgery and Neuropsychiatric Disorders for Patients With Cushing's Disease.
    Neurosurgery· 2026· PMID 41944623recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:304055(Orphanet)
  2. MONDO:0017611(MONDO)
  3. GARD:21253(GARD (NIH))
  4. Variantes catalogadas(ClinVar)
  5. Busca completa no PubMed(PubMed)
  6. Q18554902(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Tumor hipofisário
Compêndio · Raras BR

Tumor hipofisário

ORPHA:304055 · MONDO:0017611
Ensaios
8 ativos
Medicamentos
11 registrados
MedGen
UMLS
C0032019
EuropePMC
Wikidata
Papers 10a
Evidência
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