Um tumor na glândula hipófise (também conhecida como pituitária), que pode ser benigno (não canceroso) ou maligno (canceroso). A grande maioria são adenomas, tumores geralmente benignos que se desenvolvem na parte da frente dessa glândula.
Introdução
O que você precisa saber de cara
Um tumor na glândula hipófise (também conhecida como pituitária), que pode ser benigno (não canceroso) ou maligno (canceroso). A grande maioria são adenomas, tumores geralmente benignos que se desenvolvem na parte da frente dessa glândula.
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 103 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 249 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
11 genes identificados com associação a esta condição.
May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame
Cell membraneCell projection, ruffle
Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of polyubiquitin precursors as well as that of ubiquitinated proteins (PubMed:16214042, PubMed:34059922). Plays a role in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Plays an important role in cell cycle progression by deubiquitinating Aurora B/AURKB an
CytoplasmNucleusCell projection, cilium
Deafness, autosomal dominant, 85
A form of non-syndromic, sensorineural hearing loss. Sensorineural hearing loss results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA85 is characterized by progressive hearing loss, with onset in childhood or young adulthood.
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179)
NucleusCytoplasmCell membrane
Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of ta
CytoplasmNucleusMitochondrionCytoplasm, cytoskeleton, spindleCytoplasm, cytoskeleton, microtubule organizing center, centrosomeChromosomeNucleus, nucleoplasm
Glucocorticoid resistance, generalized
An autosomal dominant disease characterized by increased plasma cortisol concentration and high urinary free cortisol, resistance to adrenal suppression by dexamethasone, and the absence of Cushing syndrome typical signs. Clinical features include hypoglycemia, hypertension, metabolic alkalosis, chronic fatigue and profound anxiety.
Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apop
CytoplasmNucleusNucleus, PML bodyEndoplasmic reticulumMitochondrion matrixCytoplasm, cytoskeleton, microtubule organizing center, centrosome
Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling
NucleusChromosome, telomereNucleus, PML body
Alpha-thalassemia/impaired intellectual development syndrome, X-linked
A disorder characterized by severe psychomotor retardation, facial dysmorphism, urogenital abnormalities, and alpha-thalassemia. An essential phenotypic trait are hemoglobin H erythrocyte inclusions.
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for norma
Cell membrane
Usher syndrome 1D
USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness.
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates
Nucleus
Familial multiple endocrine neoplasia type I
Autosomal dominant disorder characterized by tumors of the parathyroid glands, gastro-intestinal endocrine tissue, the anterior pituitary and other tissues. Cutaneous lesions and nervous-tissue tumors can exist. Prognosis in MEN1 patients is related to hormonal hypersecretion by tumors, such as hypergastrinemia causing severe peptic ulcer disease (Zollinger-Ellison syndrome, ZES), primary hyperparathyroidism, and acute forms of hyperinsulinemia.
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates t
CytoplasmNucleusEndosome membraneCell membrane
Pituitary adenoma 4, ACTH-secreting
A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete. PITA4 results in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes.
Orphan receptor
Cell membrane
Pituitary adenoma 2, growth hormone-secreting
A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete. PITA2 is a growth hormone-secreting benign neoplasm, also known as somatotropinoma. It clinically results in acromegaly, a condition characterized by coarse facial features, protruding jaw, and enlarged extremities. Excessive production of growth hormone in children or adolescents before the closure of epiphyses causes gigantism, a condition characterized by abnormally tall stature.
May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation
Mitochondrion matrixNucleus
Medicamentos e terapias
Mecanismo: Dopamine D2 receptor agonist
Mecanismo: Somatostatin receptor 5 agonist
Mecanismo: Folate receptor alpha inhibitor
Mecanismo: Somatostatin receptor 5 agonist
Mecanismo: Adrenergic receptor alpha-2 agonist
Mecanismo: Somatostatin receptor 2 agonist
Mecanismo: Receptor protein-tyrosine kinase erbB-2 inhibitor
Mecanismo: Cytotoxic T-lymphocyte protein 4 inhibitor
Mecanismo: Programmed cell death protein 1 inhibitor
Mecanismo: Somatostatin receptor agonist
Variantes genéticas (ClinVar)
832 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 1 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
79 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Tumor hipofisário
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
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Outros ensaios clínicos
213 ensaios clínicos encontrados, 8 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 1.650
5-Aza-Cytidine Enhances Terminal Polyadenylation Site Usage for Full-Length Transcripts in Cells.
Aqui está o resumo focado na relevância para pacientes e médicos: O 5-aza-citidina (5-azaC), uma droga anticâncer, demonstrou em células de tumor pituitário (e outras células cancerosas) promover a produção de versões mais longas e completas de mensagens genéticas (mRNAs). Isso significa que a droga estimula as células tumorais a criarem instruções genéticas inteiras, em vez de versões mais curtas que poderiam estar alteradas. Essa descoberta revela um novo mecanismo de ação do 5-azaC e sugere que essa alteração na leitura dos genes pode ser crucial para sua eficácia no tratamento de diversos tipos de câncer, incluindo tumores da hipófise.
🇧🇷 traduzidoPreclinical pharmacology and toxicology study of an AAV8-tATP7B vector for Wilson's disease.
Este estudo descreveu o desenvolvimento de uma nova terapia genética para a Doença de Wilson, uma condição causada por mutações no gene ATP7B, utilizando um vetor viral (AAV8-tATP7B) que entrega uma versão modificada do gene. Em modelos animais, a terapia demonstrou ser eficaz ao restaurar o metabolismo do cobre e a função hepática, revertendo inclusive danos hepáticos existentes. Além disso, os testes de segurança em animais revelaram um perfil de toxicidade favorável, com apenas alterações reversíveis no fígado em doses elevadas, indicando um bom potencial para futuros ensaios clínicos em pacientes.
🇧🇷 traduzidoDRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut.
Este estudo inovador revela que a deficiência da proteína DRD2 subjaz ao adenoma de hipófise, facilitando a translocação da bactéria *Escherichia coli* do intestino para a glândula. Uma vez na hipófise, a *E. coli* é fagocitada pelas micróglias, ativando uma via inflamatória que promove o crescimento tumoral. Isso sugere novas abordagens terapêuticas para pacientes com adenoma de hipófise, incluindo o uso de antimicrobianos, modulação de micróglias ou inibidores de HMGB1.
🇧🇷 traduzidoPreoperative Metabolic Predictors of Granulation Subtypes in Somatotroph Tumors: A Multicenter Retrospective Cohort Study.
Este estudo multicêntrico investigou se o índice TG-UA (triglicerídeos e ácido úrico) pode diferenciar subtipos de tumores somatotróficos (SGSTs e DGSTs) antes da cirurgia, algo atualmente possível apenas no pós-operatório. Os resultados mostraram que o subtipo SGST, frequentemente mais agressivo, foi associado a valores mais altos de TG, GH, IGF-1 e do índice TG-UA, sendo este último um preditor independente. Para médicos e pacientes, isso representa um biomarcador sanguíneo não invasivo e pré-operatório promissor para identificar o subtipo SGST, permitindo planejar tratamentos mais direcionados e eficazes antes da intervenção cirúrgica.
🇧🇷 traduzidoA case of primary papillary epithelial tumor of the sella with reverse polarity and paired box 8 expression.
Este artigo descreve um caso de Tumor Epitelial Papilar Primário da Sela (PPETS), um tipo raro de tumor da hipófise, que apresentou características morfológicas e imunohistoquímicas inéditas, incluindo polaridade nuclear reversa e expressão de PAX-8 e sinaptofisina. Para médicos, esta descoberta é crucial, pois expande o espectro conhecido do PPETS, auxiliando no diagnóstico diferencial preciso. Isso é fundamental para distinguir corretamente este tumor de adenomas hipofisários mais comuns ou de carcinomas metastáticos, garantindo assim que o paciente receba a abordagem e o tratamento adequados.
🇧🇷 traduzidoPublicações recentes
Therapy for aggressive pituitary tumors and carcinomas.
Predictive model for the diagnosis of Ectopic Cushing Syndrome.
Intranuclear Peripheral Overexpression of Pituitary-Tumor-Transforming Gene 1: Immunohistochemical Biomarker of Lymph Node Involvement in Testicular Seminoma.
📖 RevisãoHybrid CNN-GCN framework for brain tumor MRI classification: A graph-based approach to smart healthcare diagnostics.
📖 RevisãoAssociations Between Transsphenoidal Surgery and Neuropsychiatric Disorders for Patients With Cushing's Disease.
🥇 Diretriz📚 EuropePMC1.442 artigos no totalmostrando 196
Brain tumor detection on magnetic resonance imaging scans using the artificial intelligence-based You Only Look Once algorithm.
The Journal of international medical researchNon-written guidelines in pituitary tumor surgery. The hidden curriculum.
PituitaryReal world experience with [68Ga]PentixaFor PET/CT in Primary Aldosteronism using newly developed harmonized diagnostic criteria.
Frontiers in endocrinologyApplication of a Gasket-Seal Technique Using Autogenous Bone Flap and Artificial Dura for Sellar Floor Reconstruction in Endoscopic Transnasal Pituitary Surgery.
The Journal of craniofacial surgeryUnique presentation of superficial siderosis of the central nervous system following pituitary tumor surgery: a case report and literature review.
Frontiers in neuroimagingHormonal rhythm disturbance is a potential contributor to postoperative cognitive dysfunction of pituitary tumor surgery.
Neuroendocrinology5-Aza-Cytidine Enhances Terminal Polyadenylation Site Usage for Full-Length Transcripts in Cells.
Genes to cells : devoted to molecular & cellular mechanismsHybrid Aquila optimizer-Harris Hawks optimization for CNN hyperparameter tuning in brain tumor classification.
Scientific reportsIntranasal povidone-iodine concentration and olfactory recovery after endoscopic endonasal pituitary surgery.
PituitaryPreclinical pharmacology and toxicology study of an AAV8-tATP7B vector for Wilson's disease.
Clinical and molecular hepatologyEfficacy and Safety of Pharmacologic Therapies in Acromegaly: A Systematic Literature Review and Network Meta-Analysis.
The Journal of clinical endocrinology and metabolismClonorchis sinensis promotes hepatocellular carcinoma progression via a potential PTTG1-β-catenin-c-MYC axis.
Food and waterborne parasitologyMultiple endocrine neoplasia with an atypical clinical course and a MEN1 gene variant of uncertain pathogenicity: A case report.
MedicineEndoscopic One-Nostril Transseptal Transsphenoidal Approach for Pituitary Tumors: Back to the Past-A Multi-Center Preliminary Experience and Literature Review.
CancersA Robust ConvNeXt-Based Framework for Efficient, Generalizable, and Explainable Brain Tumor Classification on MRI.
Bioengineering (Basel, Switzerland)Hypersomatotropism without concurrent diabetes mellitus in cats: 28 cases (2014-2024).
Journal of veterinary internal medicineEfficacy and long-term outcomes of dopamine agonist treatment in prolactinomas.
Best practice & research. Clinical endocrinology & metabolismMicrosurgical and Endoscopic Characterization of the Anteroinferior Wall of the Cavernous Sinus: A Cadaveric Study at the Intersection of Anatomical Fossae.
World neurosurgeryOridonin regulates pituitary-derived folliculostellate cells apoptosis via the p38 MAPK/p53 signalling pathway.
European journal of pharmacologyManagement of endocrine disease: update on the management of pituitary apoplexy.
European journal of endocrinologymiR-221/222 Facilitate Pituitary Adenoma Progression Via PHACTR4 Downregulation.
Human mutationDRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Sex-related differences in healthcare utilization and costs among patients with pituitary adenomas.
PituitaryClinical characteristics associated with somatic GNAS mutations in acromegaly: a systematic review and institutional experience.
Frontiers in endocrinologyPTTG1 regulates the TGF-β/Smad pathway to promote the growth and metastasis of gastric cancer cells.
HereditasCoexistence of Resistance to Thyroid Hormone and a Thyroid Stimulating Hormone-Secreting Pituitary Adenoma.
AACE endocrinology and diabetesNew Sparks and Spots: Molecular Imaging with Positron Emission Tomography Will Change Management of Cushing's Disease.
Endocrinology and metabolism (Seoul, Korea)Preoperative Metabolic Predictors of Granulation Subtypes in Somatotroph Tumors: A Multicenter Retrospective Cohort Study.
CNS neuroscience & therapeuticsMulti-class classification of brain tumors using optimized CNN and transfer learning techniques.
Scientific reportsDiagnosis and surgical management of a pituitary adenoma coexisting with a persistent trigeminal artery: Case report and review of the literature.
NeurocirugiaAtypical Presentation and Unexpected Resolution: The Role of Serial Cerebrospinal Fluid Analysis in Differentiating Bacterial and Viral Meningitis After Pituitary Surgery.
CureusAre PTTG1 variants associated with tumor characteristics and p53/Ki-67 expression in pituitary neuroendocrine tumors.
Frontiers in endocrinologyWidespread invasion of a giant prolactinoma via valveless venous channels: illustrative case.
Journal of neurosurgery. Case lessonsFertility and pregnancy in patients with prolactinoma.
Best practice & research. Clinical endocrinology & metabolismEndoscopic surgery for noninvasive prolactinomas: A large multicenter, single-arm, retrospective study (PRLomaSaR).
EndocrineInhibition of mitochondrial NADH:ubiquinone oxidoreductase by spinning oscillating magnetic fields causes toxicity in cancer cells.
FEBS lettersClinicopathological features and outcomes in non-functioning pituitary neuroendocrine tumors: a transcription factor-driven subtype analysis.
Journal of neuro-oncologyUBE2C/PTTG1 Regulates PANoptosis, Ferroptosis, and Autophagy to Improve Renal Ischemia-Reperfusion Injury.
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyGiant Prolactinoma: Challenges in Management.
AACE endocrinology and diabetesRole of 68Ga-DOTATOC Positron Emission Tomography in Locating Pulmonary Neuroendocrine Tumor Presenting with ACTH-Dependent Cushing's Syndrome: A Case Report.
Journal of clinical medicineDehydroepiandrosterone sulfate as a potential biomarker for assessing the etiology of canine naturally occurring Cushing's syndrome.
Domestic animal endocrinologyAuthor's reply to the Letter to the Editor by M Vijayasimha "Standardizing blood pressure phenotyping in acromegaly: a practical companion to Araujo-Castro et al.".
PituitaryControlling cortisol excess and comorbidities in Cushing's syndrome with osilodrostat.
PituitaryEfficacy and Safety of Once-Weekly Lonapegsomatropin in Adults With Growth Hormone Deficiency: foresiGHt Trial Results.
The Journal of clinical endocrinology and metabolismProspective Observational Study of 118 Clinically Nonfunctioning Pituitary Adenomas.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsDevelopment of Marine-Lenhart Syndrome During the Course of Acromegaly. A Case Report.
Internal medicine (Tokyo, Japan)Efficacy and safety of BRAF-MEK inhibitors in treatment of Chinese patients with papillary craniopharyngioma: A retrospective cohort study.
Molecular therapy. OncologyHybrid fractal ConvXGBNet for brain tumor classification with log-cosh dice loss - cascaded V-Net based segmentation based on MRI images.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research SocietyFrom misclassified AIP variant to carney complex: a case report and retrospective evaluation of PRKAR1A in pituitary tumor predisposition.
PituitarySpontaneous regression of a growth hormone-secreting pituitary adenoma following thyroidectomy for toxic multinodular goiter with superior vena cava obstruction: Report of a rare case.
Medicine internationalMetabolic inflammation, brain age and cognitive functioning in short- and long-term clinical weight loss trials.
EBioMedicineKi-67 and Preoperative Hypocortisolism are Predictive Factors for Postoperative Diabetes Insipidus After Endoscopic Pituitary Tumor Resection.
World neurosurgeryMulti-omics integration identifies ASPH and PTTG1 as potential causal drivers of lung adenocarcinoma progression and immune evasion.
Frontiers in immunologyMulticlass Brain Tumor Detection with Attention-Embedded CNN Framework: Advancing Toward Decentralized Deep Learning-Based Health Monitoring.
IEEE journal of biomedical and health informaticsAnesthetic Management for Pituitary Tumor Resection in a Patient With Acromegalic Cardiomyopathy: A Case Report.
Clinical case reportsCase Report: A new noninvasive device-based treatment of a mesencephalic H3 K27M glioma.
Frontiers in oncologyA Case of Adrenocorticotropin-dependent Cushing Syndrome with Osilodrostat Exposure in Early Pregnancy.
JCEM case reportsInhibition of PTTG1 suppresses proliferation and promotes differentiation of neuroblastoma cells by inducing autophagy.
Pediatric surgery internationalInhibition of DRP1-mediated Mitochondrial Fission and NRF2/HO-1/GPX4-mediated Ferroptosis by Mdivi-1 Protects Against Vascular Cognitive Impairment.
Molecular neurobiologyMultidimensional tumor-blood profiling uncovers systemic lymphocyte-monocyte imbalance in pituitary neuroendocrine tumors.
Signal transduction and targeted therapyHistopathological evaluation of dopamine receptor D2 expression in symptomatic gonadotroph pituitary neuroendocrine tumors: a case series including a rare metastatic case responsive to a dopamine agonist.
Brain tumor pathologyArtificial Intelligence Models as Predictors of Poor Outcomes in Transsphenoidal Pituitary Tumor Surgeries: A Diagnostic Test Accuracy Review.
World neurosurgeryApproach to the Patient With Dopamine-Resistant Microprolactinoma.
The Journal of clinical endocrinology and metabolism[Clinical management of pituitary prolactinoma from the perspective of obstetrics and gynecology: from reproductive health to lifespan care].
Zhonghua yi xue za zhi[Refractory pituitary prolactinoma:current treatment status and challenges].
Zhonghua yi xue za zhiErdheim-Chester Disease Mimicking a Malignant Pituitary Stalk Tumor With Ventricular Dissemination: A Case Report.
Brain tumor research and treatmentResolution of Hyperprolactinemia Caused by Pituitary Stalk Compression After Transsphenoidal Surgery for Pituitary Tumors.
Brain tumor research and treatmentEarly Postoperative Decline in Insulin-Like Growth Factor 1 (IGF-1) Predicts Surgical Remission of Acromegaly.
World neurosurgeryThe relevance of patient-reported outcome measures in hypopituitarism: HIV therapy adherence and suicidal ideations resolved by GH replacement.
Endocrinology, diabetes & metabolism case reportsPrevalence and evolution of hypertension in a large Iberian cohort of patients with acromegaly.
PituitaryClinically Nonfunctioning Pituitary Adenomas.
Endocrinology and metabolism clinics of North AmericaDiagnosis of Cushing's Disease.
Endocrinology and metabolism clinics of North AmericaRapid and Sustained Response of Biochemically Uncontrolled Acromegaly to Once-daily Oral Paltusotine Treatment.
The Journal of clinical endocrinology and metabolismSuccess of 177Lu-DOTATATE therapy in a metastatic pituitary neuroendocrine tumor.
Endocrine oncology (Bristol, England)Fine-tuned ResNet34 for efficient brain tumor classification.
Scientific reportsSellar-suprasellar pituitary lymphoma mimicking pituitary adenoma: a case report with literature review.
Journal of surgical case reportsAcromegaly and Morris Syndrome: Description of a Clinical Case.
Endocrine, metabolic & immune disorders drug targetsRapid Growth of a Lung Cancer Metastasis to a Pituitary Neuroendocrine Tumor: A Case Report and Literature Review.
NMC case report journalGrowth Hormone Assay-Adjusted Standardization Reveals Distinct Clinical Phenotypes in Acromegaly.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsApplication of algorithms based on improved YOLO in MRI image detection of brain tumors.
Frontiers in neurologyThe clinical picture of symptomatic Rathke cleft cysts in children.
Journal of pediatric endocrinology & metabolism : JPEMPTTG1IP Orchestrates Epithelial-Mesenchymal Transition and DNA Damage Response in Thyroid Cancer Progression.
Frontiers in bioscience (Landmark edition)Pituitary Neuroendocrine Tumor or Pituitary Adenoma? Let's Ask the Epigenome!
Endocrine pathologyOsilodrostat dose impact on efficacy/safety in Cushing's disease: large, pooled analysis of LINC 2, 3, and 4.
European journal of endocrinologyRisk factors and prognosis of visual and cranial nerve deficits in patients operated for pituitary tumor - with a focus on intrasellar pressure.
Acta neurochirurgicaCase Report: Metabolic alterations and cholesterol esterification in a low-grade diffuse astrocytoma patient who progressed to glioblastoma at recurrence.
Frontiers in oncologyUsing the Desmopressin Stimulation Test to Assess for Residual Tumor in Cushing Disease With Cyclic Hypercortisolism.
JCEM case reportsPTTG1-mediated reprogramming of asparagine metabolism enhances DNA damage repair and leads to compromised antitumor immunity in prostate cancer.
Urologic oncologyPrenatal alcohol exposure increases the aggressiveness of estrogen-induced pituitary tumors in male rats.
Alcohol, clinical & experimental research[Dilated cardiomyopathy in a patient with Cushing's disease - clinical presentation, diagnosis and treatment: a case report].
Problemy endokrinologiiPolymeric nanoparticles for liver-targeted pituitary tumor-transforming gene 1 silencing in rats with chronic liver disease.
Nanomedicine : nanotechnology, biology, and medicineMR Elastography of Pituitary Macroadenomas with Intraoperative and Immunofluorescence correlation: A Feasibility study along with Literature Review.
La Clinica terapeuticaLightweight Transfer Learning Models for Multi-Class Brain Tumor Classification: Glioma, Meningioma, Pituitary Tumors, and No Tumor MRI Screening.
Journal of imaging informatics in medicineCombined endoscopic endonasal transsphenoidal and microscopic transcranial approaches for the primary resection of giant pituitary adenomas.
Neuro-ChirurgieFunctionality of Pituitary Tumors Impacts Sinonasal Quality of Life Before and After Endoscopic Surgery.
The LaryngoscopeMetabolic Factors Related to Interpersonal Dysfunction in Acromegaly: A Nationwide Cross-Sectional Study in China.
CNS neuroscience & therapeuticsUpdate on Medical Treatment of Cushing's Syndrome.
DrugsGrowth hormone deficiency in Cushing's syndrome: an update on diagnosis and management.
Expert review of endocrinology & metabolismModulation of INa, Ih, and IK(erg) by Extracellular or Intracellular QX-314 (N-(2,6-dimethylphenylcarbamoylmethyl) triethylammonium bromide) in Pituitary Tumor Cells.
International journal of molecular sciencesPaeoniflorin attenuates hyperprolactinemia by targeting the pituitary mPRα-mediated, dopamine receptor-independent signaling in vivo and in vitro.
Toxicology and applied pharmacologyClinical characteristics and temporal trends of lumbar drain use in minimally invasive resection of pituitary neoplasms.
World journal of otorhinolaryngology - head and neck surgeryPTTG1 as a common promising target for PCOS, Ovarian Cancer, and Major Depressive Disorder patients.
Computational biology and chemistryEcchordosis Physaliphora: A Rare and Challenging Clinical Entity in a Patient With Acromegaly.
JCEM case reportsDecoding the PTTG family's contribution to LUAD pathogenesis: a comprehensive study on expression, epigenetics, and therapeutic interventions.
HereditasDeciphering the Potential Causal and Prognostic Relationships Between Gut Microbiota and Brain Tumors: Insights from Genetics Analysis and Machine Learning.
Exploration (Beijing, China)Hypopituitarism Accompanied with Delusion: The Effects of Growth Hormone Replacement Therapy.
Internal medicine (Tokyo, Japan)A Web-Deployed, Explainable AI System for Comprehensive Brain Tumor Diagnosis.
Neurology internationalThe STUB1-TPIT axis regulates the secretion of adrenocorticotrophic hormone in cushing disease.
Journal of translational medicineOptimized deep learning for brain tumor detection: a hybrid approach with attention mechanisms and clinical explainability.
Scientific reportsA case of primary papillary epithelial tumor of the sella with reverse polarity and paired box 8 expression.
Brain tumor pathologyA novel residual network based on multidimensional attention and pinwheel convolution for brain tumor classification.
Scientific reportsA Comparative Study on Clinical Features, Surgical Outcomes, and Postoperative Complications in Pituitary Apoplexy vs. Non-Apoplexy Patients.
Annali italiani di chirurgiaEvaluating pituitary tumor management: aligning with pituitary tumor centers of excellence criteria.
PituitaryConsensus on acromegaly therapeutic outcomes: an update.
Nature reviews. EndocrinologyPredictive model for meningitis after pituitary tumor resection by endoscopic nasal trans-sphenoidal sinus approach.
European journal of medical researchInitial Clinical Experience Using Naked-Eye 3D 4K Exoscope for Vestibular Schwannoma.
The Journal of craniofacial surgeryPyramidal attention-based T network for brain tumor classification: a comprehensive analysis of transfer learning approaches for clinically reliable and reliable AI hybrid approaches.
Scientific reportsTargeting Src tyrosine kinase to enhance radioiodide uptake in breast cancer.
Endocrine-related cancerA Novel Gene Expression Profile and Combined Effects in the Pathogenesis of Adrenocorticotropic Hormone-Secreting Pituitary Neuroendocrine Tumors.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes AssociationPerformance Evaluation of Artificial Intelligence Techniques in the Diagnosis of Brain Tumors: A Systematic Review and Meta-Analysis.
CureusCurrent understanding of the role of DNA methylation in pituitary neuroendocrine tumors.
Neuro-oncology advancesClinical integration and application of the 2022 WHO pituitary tumor classification.
Neuro-oncology advancesAggressive pituitary tumors and pituitary carcinomas: Definition, management, and overview for clinical practice.
Neuro-oncology advancesEffects of Total Intravenous Anesthesia and Inhalational Anesthesia on Postoperative Recovery in Patients Undergoing Transsphenoidal Pituitary Surgery:A Systematic Review.
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae SinicaeA 62-Year-Old Man With New-Onset Hypertrophic Cardiomyopathy 25 Years After Surgical Remission of Acromegaly.
Case reports in endocrinologyDevelopment of a Minimum Dataset for the Global Monitoring of the Safety and Efficacy of Growth Hormone Replacement in Adults With Growth Hormone Deficiency (AGHD).
Clinical endocrinologyRu(II)-Photodynamic Therapy Suppresses Nonfunctioning Pituitary Adenoma Growth by Targeting PI3K/AKT/p53 Signaling.
ACS applied bio materialsPituitary Apoplexy in a Cat With Presumed Acute Diabetes Insipidus.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Comparison of Clinical Outcomes between Microscopic and Endoscopic Transsphenoidal Pituitary Tumor Resection.
Journal of neurological surgery. Part B, Skull baseManagement of Osilodrostat Therapy in Patients With Cushing's Syndrome: A Modified Delphi Consensus Panel.
Journal of the Endocrine SocietyProgression of potentially aggressive pituitary neuroendocrine tumors after radiotherapy: risk factors, management, and outcomes.
European journal of endocrinologyCase Report: Pituitary metastasis from prostate adenocarcinoma: an integrated diagnosis via 68Ga-PSMA PET/CT and methylome analysis.
Frontiers in medicineFactors affecting disease control after pituitary tumor resection in acromegaly: What is the current evidence?
World journal of radiologyhe Dark Corner of the Pituitary Gland: A Case Report and Literature Review of Primary Melanocytoma.
Current medical imagingImage-based detection of the internal carotid arteries and sella turcica in endoscopic endonasal transsphenoidal surgery.
Neurosurgical focusEndoscopic endonasal surgery using indocyanine green fluorescence endoscope for Cushing's disease caused by mixed intrasellar gangliocytoma and adrenocorticotropin adenoma: illustrative case.
Journal of neurosurgery. Case lessonsReduction of polycystic kidney and liver volumes in a patient with tolvaptan-resistant autosomal dominant polycystic kidney disease and acromegaly during lanreotide therapy.
CEN case reportsHospital procedural volume is inversely linearly associated with complications in endoscopic endonasal transsphenoidal resection of pituitary tumors.
Journal of neurosurgeryEffects of lanreotide autogel immediately after a single injection for thyrotropin-producing pituitary tumor.
Endocrinology, diabetes & metabolism case reports[Application of autologous pedicled nasal mucosal flaps by "three-step" strategy in repairing of cerebrospinal fluid leakage following transsphenoidal pituitary adenoma surgery].
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgeryHypersomatotropism and Hypercortisolism Caused by a Plurihormonal Pituitary Adenoma in a Dog.
Journal of veterinary internal medicineDiagnostic strategies for central adrenal insufficiency in clinical practice: authors' response.
European journal of endocrinologyAdvances in Drug Treatments for Male Patients with Prolactinomas.
NeuroendocrinologyPresumed nonadaptation to a multifocal intraocular lens masking visual loss from a pituitary tumor.
American journal of ophthalmology case reportsPituitary tumor-transforming gene 1 and endocrine cancers: an up-to-date review through history, current insights and future perspectives.
Endocrine-related cancerPituitary Apoplexy Following Gonadotropin-Releasing Hormone Agonist Therapy: A Rare and Life-Threatening Complication.
CureusA Pituitary Macroadenoma Cosecreting Prolactin and Growth Hormone in a Patient With Multiple Endocrine Neoplasia Type 4.
JCEM case reportsThe effect of hyperprolactinemia and its treatment on oxidative stress.
Endocrine researchAir Pollution and Pituitary Adenoma Pathogenesis: Unraveling Environmental Impacts on Neuroendocrine Function and Tumorigenesis.
Journal of xenobioticsAdvanced Magnetic Resonance Imaging Techniques for Localization of a Small Thyrotropin-Secreting Pituitary Tumor.
JCEM case reportsTargeting FSHR is a highly promising strategy for improving cognitive impairment in postmenopausal women.
Molecular psychiatryAnesthetic Considerations for the Transsphenoidal Resection of a Pituitary Tumor in an Acromegalic Patient: A Case Report.
CureusSurgery for the treatment of arterial hypertension in patients with unilateral adrenal incidentalomas and mild autonomous cortisol secretion (CHIRACIC): a multicentre, open-label, superiority randomised controlled trial.
The lancet. Diabetes & endocrinologyThe impact of pituitary adenomas on cognitive performance: a systematic review.
Frontiers in endocrinologyCombined 6th and 12th Cranial Nerve Palsies (Godtfredsen Syndrome) due to Clival Lesions.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology SocietyAssociation of coagulation-related indicators with postoperative venous thromboembolism occurrence in patients with pituitary tumors.
Scientific reportsRecent Advances in Ionic Mechanisms in Pituitary Cells: Implications for Electrophysiological and Electropharmacological Research.
Journal of clinical medicineEvidence for Pituitary Repression of the Human Growth Hormone-Related Placental Lactogen Genes and a Role for P Sequences.
International journal of molecular sciencesMicroRNA Is Downregulated in Invasive Non-Functioning Pituitary Adenomas.
International journal of molecular sciencesTargeting Autophagy for Pituitary Tumors.
CancersCocaine-Induced Apoplexy of a GH-Secreting Pituitary Tumor.
Clinical case reportsIntraoperative Diagnosis and Management of Arginine Vasopressin Disorder During Pituitary Tumor Resection via Transsphenoidal Endoscopic Navigation.
CureusThe Role of Late-Night Salivary Cortisol in the Assessment of Endocrine Remission in Patients With Cushing's Disease After Pituitary Radiotherapy.
Clinical endocrinologyAndrographolide attenuates PM2.5-induced blood-brain barrier damage via antioxidant and PI3K/AKT/mTOR/NRF2 pathways.
International immunopharmacologyImpulse Control Disorders in Patients With Hyperprolactinemia on Dopamine Agonist Therapy-How Concerned Should We Be?
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsPituitary folliculo-stellate cells modulate tumor vasculature and extracellular matrix composition in experimental lactosomatotropinomas.
Biochemical and biophysical research communicationsFactors Associated With a Higher 30-Day Hospitalization Period for Pituitary Adenoma Patients: Introducing a Novel Outcome Metric.
NeurosurgeryClinicopathological characteristics associated with the prognosis of recurrent gonadotroph tumors.
Endocrine-related cancerEnSLDe: an enhanced short-range and long-range dependent system for brain tumor classification.
Frontiers in oncologyReal-World Experience with Pasireotide-LAR in Cushing's Disease: Single-Center 12-Month Observational Study.
Journal of clinical medicineDual-Stream Contrastive Latent Learning Generative Adversarial Network for Brain Image Synthesis and Tumor Classification.
Journal of imagingNavigating prognostic strategies for GH- and PRL-secreting pituitary neuroendocrine tumors: key insights from a clinicopathological study.
Frontiers in endocrinologyMetformin induces apoptosis in pituitary-derived folliculostellate cells via the IL-6/ERK pathway.
Discover oncologyThe prevalence and predictors of Cushing disease recurrence: a 10-year experience of a pituitary tumor center of excellence.
EndocrineEvaluating the Impact of Attention Mechanisms on a Fine-Tuned Neural Network for Magnetic Resonance Imaging Tumor Classification: A Comparative Analysis.
CureusSuccessful Volume Control of Invasive Pituitary Adenoma Tumor With Pasireotide: A New Horizon for a Challenging Disease.
JCEM case reportsPulmonary Fibrosis in a Patient With a Prolactinoma on Dopamine Agonists: Coincidence or Consequence.
JCEM case reportsContemporaneous Presentation of Ocular Myasthenia Gravis With Pituitary Apoplexy: A Diagnostic Dilemma.
CureusPreoperative Prediction of Non-functional Pituitary Neuroendocrine Tumors and Posterior Pituitary Tumors Based on MRI Radiomic Features.
Journal of imaging informatics in medicineRecovery of pituitary function in patients with apoplexy immediately after surgical resection of necrotic tumors.
EndocrineThyroid-Stimulating Hormone/Growth Hormone Cosecreting Pituitary Adenoma With Normal Thyroid-Stimulating Hormone Level.
JCEM case reportsComparative analysis of the effects of microscopic vs. neuroendoscopic transsphenoidal surgery on visual and pituitary function and postoperative recurrence factors in patients with pituitary tumors.
American journal of translational researchMethodology of high-dimensional flow cytometry in monitoring immune microenvironment of pituitary neuroendocrine tumors.
Cytometry. Part B, Clinical cytometry[Abnormal elevation of growth hormone in patients with pituitary adenoma combined with cirrhosis: A case report].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciencesEndocrine manifestations of pediatric CNS tumors at diagnosis and as sequalae of treatment.
Seminars in pediatric neurologyComparison of Microscopic and Endoscopic Transsphenoidal Surgery for Pituitary Adenomas.
CureusA Corticotropin-Secreting Adenoma in the Setting of von Hippel-Lindau Disease.
JCEM case reportsMyxoedema Coma in a Medically Compliant Young Patient Presenting With Cardiogenic Shock and Requiring Cardiopulmonary Resuscitation.
CureusEmploying Squeeze-and-Excitation Architecture in a Fine-Tuned Convolutional Neural Network for Magnetic Resonance Imaging Tumor Classification.
CureusRelationship between serum CEACAM1 levels and prognosis and temozolomide chemotherapy sensitivity in patients undergoing neuroendoscopic transsphenoidal pituitary tumor resection.
Pakistan journal of pharmaceutical sciencesTranscriptomic analysis of the anti-tumor effects of leflunomide in prolactinoma.
Scientific reportsEvidence for effective suppression of INa and IK(DR) by AS2034178 (bis{2-[(4-{(4'-(2-hydroxyethoxy)-2'-methyl[1,1'-biphenyl]-3-yl)methoxy}phenyl]methyl]-3,5-dioxo-1,2,4-oxadiazolidin-4-ide} tetrahydrate), an agonist of free fatty acid receptor.
Neuroscience lettersEvaluation of pituitary tumor volume as a prognostic factor in acromegaly: A cross-sectional study in two centers.
World journal of radiologyCirculating miR-20a-5p as a biomarker associated with cabergoline responsiveness in patients with hyperprolactinemia and pituitary adenomas.
European journal of endocrinologyEctopic GHRH production: revisiting a rare cause of acromegaly.
Reviews in endocrine & metabolic disordersResistant PRL-secreting PitNET associated with breast carcinoma: a case report and literature review.
International cancer conference journalAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- 5-Aza-Cytidine Enhances Terminal Polyadenylation Site Usage for Full-Length Transcripts in Cells.
- Preclinical pharmacology and toxicology study of an AAV8-tATP7B vector for Wilson's disease.
- DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut.
- Preoperative Metabolic Predictors of Granulation Subtypes in Somatotroph Tumors: A Multicenter Retrospective Cohort Study.
- A case of primary papillary epithelial tumor of the sella with reverse polarity and paired box 8 expression.
- Therapy for aggressive pituitary tumors and carcinomas.
- Predictive model for the diagnosis of Ectopic Cushing Syndrome.
- Intranuclear Peripheral Overexpression of Pituitary-Tumor-Transforming Gene 1: Immunohistochemical Biomarker of Lymph Node Involvement in Testicular Seminoma.
- Hybrid CNN-GCN framework for brain tumor MRI classification: A graph-based approach to smart healthcare diagnostics.
- Associations Between Transsphenoidal Surgery and Neuropsychiatric Disorders for Patients With Cushing's Disease.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:304055(Orphanet)
- MONDO:0017611(MONDO)
- GARD:21253(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q18554902(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
