A Doença de Castleman (DC) é uma condição benigna (que não é câncer) em que as células de defesa do corpo (chamadas linfócitos) se multiplicam mais do que o normal. Ela pode se apresentar de forma localizada (em apenas um lugar) ou multicêntrica (em várias partes do corpo). Os sintomas são muito variados, indo desde o aumento discreto dos gânglios linfáticos (ínguas) sem causar sintomas, até crises repetidas de inchaço generalizado dos gânglios com sintomas graves que afetam o corpo todo.
Introdução
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A Doença de Castleman (DC) é uma condição benigna (que não é câncer) em que as células de defesa do corpo (chamadas linfócitos) se multiplicam mais do que o normal. Ela pode se apresentar de forma localizada (em apenas um lugar) ou multicêntrica (em várias partes do corpo). Os sintomas são muito variados, indo desde o aumento discreto dos gânglios linfáticos (ínguas) sem causar sintomas, até crises repetidas de inchaço generalizado dos gânglios com sintomas graves que afetam o corpo todo.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 21 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 49 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
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Mostrando amostra de 200 publicações de um total de 1.406
Mesenteric unicentric Castleman's disease misdiagnosed as gastrointestinal neuroendocrine tumour.
Castleman's disease is a rare lymphoproliferative disorder with a variable presentation ranging from no clinical symptoms to fever and fatigue. We report a case of a male in his 30s who presented to the emergency department with non-specific symptoms, including fever, cough, diarrhoea, abdominal pain and findings of bloody mucus in his stool. Preoperative imaging using CT showed a hypervascular mass in the abdomen measuring 3.9 cm. Positron emission tomography with Gallium-68 DOTA-Tyr3-octreotate (DOTATATE) showed moderate radiotracer uptake, raising suspicion for a neuroendocrine tumour. Preoperative endoscopic ultrasound biopsy results showed a benign reactive lymph node. The patient's case was discussed at a multidisciplinary tumour board, where diagnostic/therapeutic resection was advised. Following resection of the mass, it was found to be an enlarged lymph node with histopathological features consistent with hyaline vascular Castleman's disease. The patient did not experience any complications, postoperative imaging was unremarkable, and he is being monitored closely for recurrence.
Snapshot Look at Castleman Disease.
Castleman disease (CD) is a rare and heterogeneous group of lymphoproliferative disorders characterised by abnormal proliferation of lymphoid tissue. First described in the 1950s, it has since been classified into two major clinical forms: unicentric CD (UCD), involving a single lymph node region and multicentric CD (MCD), which affects multiple regions and is often systemic. Further subclassification of MCD includes HHV8-associated MCD, POEMS-associated MCD and idiopathic MCD (iMCD), each with distinct pathophysiologic mechanisms and clinical implications. This review summarises current understanding of the epidemiology, clinical presentation, histopathology, pathogenesis and diagnostic challenges of CD. It also explores recent advances in molecular biology, including the role of interleukin-6 (IL-6), human herpesvirus-8 (HHV8) and aberrant immune signalling in disease progression. Therapeutic strategies vary significantly depending on the subtype and range from surgical resection in UCD to immunotherapy, siltuximab and cytotoxic chemotherapy in MCD. Despite progress, CD remains underdiagnosed and poorly understood, especially in its idiopathic forms. Continued research into its molecular underpinnings and targeted treatments is critical to improving patient outcomes and establishing evidence- based guidelines.
Monoclonal neutralizing antibodies elicited by infection with Kaposi sarcoma-associated herpesvirus reveal critical sites of vulnerability on gH/gL.
Kaposi sarcoma-associated herpesvirus (KSHV) is an oncogenic virus that causes Kaposi sarcoma, primary effusion lymphoma and multicentric Castleman disease. A vaccine that prevents KSHV infection or serves in the treatment of KSHV-related diseases represents a critical unmet need, however, the types of immune responses a vaccine should elicit have not been well defined. The gH/gL glycoprotein complex is an important target of KSHV-neutralizing antibodies, but the epitope specificities targeted by these antibodies remain unknown. Here, we isolated 12 gH/gL-specific monoclonal antibodies (mAbs) from KSHV-infected donors and performed structure/function analyses. These mAbs bind recombinant gH/gL with nanomolar affinities and epitope binning analyses revealed that the mAbs bind to 5 epitope clusters on gH/gL. Seven mAbs were able to neutralize KSHV infection of epithelial cell lines. Two potent neutralizing mAbs mapped to the EphA2 binding site as determined by inhibition of the receptor-ligand interaction and negative stain electron microscopy (nsEM) of the mAb/gH/gL complex. The epitopes of other neutralizing mAbs targeting novel sites of vulnerability were determined by a combination of cryogenic electron microscopy and nsEM. Together, these mAbs help to define the relevant epitope targets for KSHV vaccine design, have utility in understanding the role of antibodies in preventing KSHV infection, enable the development of immunotherapy approaches, and provide valuable tools to understand the molecular details of the KSHV entry process.
Comprehensive analysis of subtype-specific outcomes and management in Castleman disease: a 20-year cohort study.
Castleman disease (CD) is a heterogeneous group of lymphoproliferative disorders anatomically classified by distribution (unicentric CD [UCD], oligocentric CD [oligoCD], or multicentric CD [MCD]). Human herpes virus 8-negative MCD is called idiopathic MCD (iMCD), which includes clinical subtypes with varying phenotypes and responses: TAFRO (thrombocytopenia, anasarca, fever, renal dysfunction and/or reticulin fibrosis, and organomegaly), IPL (idiopathic plasmacytic lymphadenopathy), and not otherwise specified. OligoCD has recently emerged as an intermediate form between UCD and MCD, with unclear clinical behavior, and IPL has not been validated in a Western cohort. We retrospectively analyzed 217 patients with CD evaluated at our institution between January 2004 and August 2024. Survival probabilities were compared using log-rank tests. Overall, 57% had UCD, 20% had oligoCD, and 23% had iMCD. Patients with oligoCD and iMCD more frequently exhibited systemic symptoms than those with UCD. Patients with oligoCD and iMCD had significantly shorter event-free survival (EFS) of 8.9 and 2.3 years, respectively, than those with UCD (not reached; P< .001 and P< .02). Among iMCD subtypes, iMCD-IPL demonstrated a longer EFS than iMCD-TAFRO (P = .02), with no deaths during the follow-up periods. The results validate oligoCD and iMCD-IPL as new subtypes in this Western cohort. The survival outcome in oligoCD was intermediate between UCD and iMCD, with only a subset of patients with oligoCD requiring systemic therapy. iMCD-IPL had a favorable survival outcome in this US cohort, similar to what has been reported in non-Western countries. Tailoring treatment strategies to disease subtypes and vigilant monitoring of oligoCD for progression may improve survival outcomes in CD.
Unicentric Castleman Disease as a Sufficient and Reversible Cause of Steroid-Refractory Autoimmune Hemolytic Anemia in a Child.
Publicações recentes
Morphological characteristics of the renal lesion in TAFRO syndrome and POEMS syndrome: a retrospective and multicenter study.
Deciphering the full spectrum of Castleman diseases based on a cohort of 700 patients in a western country.
Efficacy and safety of steroid-sparing strategy in the treatment of AIHA associated with KSHV/HHV-8 positive multicentric Castleman disease.
Hyaline Vascular Castleman Disease Presenting as Occipital Scalp Swelling in a Child.
A rare case of unicentric Castleman disease in the posterior mediastinum: case report and integrated literature review.
📚 EuropePMC1.404 artigos no totalmostrando 193
Angiomatous Subtype of Penile Kaposi Sarcoma With Concurrent HIV-Negative Multicentric Castleman Disease: A Case Report.
International journal of surgical pathologyRecovery trajectories of TAFRO syndrome: a single-center case series highlighting prolonged thrombocytopenia and anasarca.
Immunological medicineClinical feature analysis of pediatric Castleman disease with renal involvement.
Pediatric nephrology (Berlin, Germany)Kaposi sarcoma herpesvirus (KSHV) subtypes and impact on outcomes in KSHV-associated diseases.
The Journal of infectious diseasesInterfollicular Plasmacytosis and Hyperplastic Germinal Centers in Idiopathic Multicentric Castleman Disease, Idiopathic Plasmacytic Lymphadenopathy Subtype.
American journal of hematologyBreast-implant associated unicentric castleman disease: a case report.
Current problems in cancer. Case reportsCase Report: Endothelial-targeted bridging therapy for a TTP-like phenotype in fulminant iMCD-TAFRO.
Frontiers in immunologyLimited discriminatory performance of the iMCD-IPI in a Western cohort.
The oncologistTransformation of Castleman Disease into Angioimmunoblastic T-Cell Lymphoma Complicated by Hemophagocytic Lymphohistiocytosis: A Case Report and Literature Review.
Case reports in oncologyHow I diagnose Castleman disease.
American journal of clinical pathologySpatial and bulk transcriptomics reveal distinct molecular signatures in Kaposi sarcoma with and without other KSHV-associated diseases.
Journal of translational medicineKaposi Sarcoma-Associated Herpesvirus Infection and Complications Among Solid Organ Transplant Recipients - United States, January 2021-September 2025.
MMWR. Morbidity and mortality weekly reportTwo Cases of Systemic Lupus Erythematosus With Castleman Disease.
CureusSiltuximab as a first-line therapy for idiopathic multicentric Castleman disease: a retrospective analysis based on the SiMuLa study of the Italian regional network.
Frontiers in oncologyElucidating the grading intricacies of idiopathic multicentric Castleman disease histopathology: a pathologist's perspective.
American journal of clinical pathologyEffectiveness of tocilizumab for IgA vasculitis associated with idiopathic multicentric Castleman's disease: Two cases and literature review.
Modern rheumatology case reportsThe value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the diagnosis and evaluation of TAFRO syndrome: a review of cases and literature.
Clinical radiologyIs "severe" idiopathic multicentric Castleman disease (iMCD)-idiopathic plasmacytic lymphadenopathy (IPL) really severe?
HemaSphereSevere polyneuropathy in HIV-negative human herpesvirus 8-associated multicentric Castleman disease successfully treated with rituximab and liposomal doxorubicin.
Journal of infection and chemotherapy : official journal of the Japan Society of ChemotherapyMesenteric unicentric Castleman's disease misdiagnosed as gastrointestinal neuroendocrine tumour.
BMJ case reportsLong-term safety and efficacy of filgotinib in patients with idiopathic multicentric Castleman disease: 52-week results from a Phase Ib clinical trial.
Modern rheumatologyMesenteric Castleman disease: Two case reports and review of literature.
World journal of gastrointestinal surgeryUnicentric Castleman Disease of the Mesentery Mimicking a Gastrointestinal Stromal Tumor: A Case Report.
CureusSystemic bone destruction as a presentation of idiopathic multicentric Castleman disease.
British journal of haematologyClinical diagnosis and treatment analysis of 11 cases of unicentric Castleman disease in the retroperitoneum.
Frontiers in oncologyConcurrent Idiopathic Multicentric Castleman Disease with TAFRO and Sjögren's Syndrome in a Young Patient: A Challenging Diagnostic Overlap.
European journal of case reports in internal medicineSnapshot Look at Castleman Disease.
Journal of cellular and molecular medicineRetrospective analysis of primary extranodal unicentric Castleman disease: a systematic review.
Frontiers in medicineUnicentric Castleman Disease Presenting with a Ruptured Pseudoaneurysm within the Tumor: A Case Report.
Surgical case reportsSuccessful Bilateral-Lung Transplantation With Long Survival Time for Multicentric Castleman Disease With Fatal Pulmonary Involvement.
Transplantation proceedingsMulticentric Castleman disease (MCD) presenting with retiform purpura: A rare dermatologic manifestation of a systemic disease.
JAAD case reportsUnicentric Castleman disease with paraneoplastic pemphigus in a young woman: a case report.
Frontiers in medicineA Rapid Transition From Thrombocytosis to Thrombocytopenia in Idiopathic Multicentric Castleman Disease.
The Journal of dermatologyHHV-8/KSHV in Solid Organ Transplantation: Current Gaps of Knowledge and Future Directions.
Transplant infectious disease : an official journal of the Transplantation SocietyOligocentric Castleman Disease (OligoCD): A Novel Diagnostic Entity in the Spectrum of Castleman Disease.
CureusThe clinical significance of the Mediterranean fever gene MEFV variants in Castleman disease.
Communications medicineThe rare report of unicentric Castleman disease with concurrent myasthenia gravis and paraneoplastic pemphigus: a case report with a focused review of the literature.
Frontiers in oncologyTAFRO syndrome requiring combined IL 6 and IL 1 inhibition: a case report.
Frontiers in immunologyKSHV and cancer: understanding the oncogenic machinery for next-generation diagnostic tools and therapies.
Archives of microbiologyUnicentric Castleman Disease as a Sufficient and Reversible Cause of Steroid-Refractory Autoimmune Hemolytic Anemia in a Child.
Pediatric blood & cancerClinical features and treatment outcomes of POEMS-associated Castleman disease.
British journal of haematologyPolyclonal hypergammaglobulinemia, infiltration of the salivary glands, lymphadenopathy, and kidney damage - Mikulicz's disease, Sjögren's syndrome, or Castleman's disease? Case report and overview of differential diagnosis and treatment.
Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnostiRuxolitinib in relapsed/refractory TAFRO syndrome: a report of two cases, including one positive for Epstein-Barr virus, and a literature review.
International journal of hematologyHyperenhancing paravertebral mass in an adolescent: A rare presentation of unicentric Castleman disease.
Radiology case reportsRetrospective cohort evaluation of renal involvement in non-HIV castleman disease patients from a single academic center in Beijing, China.
Annals of hematology[Castleman disease with systemic manifestation: a case report].
The Pan African medical journalClinicohistopathological features and outcome of cutaneous and systemic plasmacytosis in 21 Chinese cases: A retrospective study.
Indian journal of dermatology, venereology and leprologyIdiopathic Multicentric Castleman Disease-TAFRO: A Potentially Curable Disease?
American journal of hematologyMonoclonal neutralizing antibodies elicited by infection with Kaposi sarcoma-associated herpesvirus reveal critical sites of vulnerability on gH/gL.
PLoS pathogensEndoscopic-Assisted Excision of Parotid Castleman Disease in Pediatric Patients: A Case Series of Three Patients and a Literature Review.
The American journal of case reportsEBV+ and Kaposi's Sarcoma Herpesvirus-Associated Multicentric Castleman Disease in a Patient With HIV Infection: A Case Report.
Case reports in infectious diseasesFrom the archives of MD Anderson Cancer Center: Paraneoplastic autoimmune multiorgan syndrome (PAMS) associated with stroma-rich Castleman disease.
Annals of diagnostic pathologyA Placebo-Controlled Exploratory Trial of Sirolimus for Tocilizumab-Resistant Idiopathic Multicentric Castleman Disease: Early Termination and Long-Term Extension Results Based on Descriptive Results From Two Patients.
CureusDysregulated lymphocyte localization in idiopathic multicentric Castleman disease.
bioRxiv : the preprint server for biologyComprehensive analysis of subtype-specific outcomes and management in Castleman disease: a 20-year cohort study.
Blood advancesIdiopathic Multicentric Castleman Disease With Severe Eosinophilia and Diffuse Centrilobular Nodule-A Rare Case Report.
Case reports in hematologyCastleman disease mimicking prostate cancer metastasis: diagnostic implications of [68Ga]Ga-PSMA-11 PET/CT.
Nuclear medicine review. Central & Eastern EuropeSystemic lupus erythematosus combined with Castleman disease: a case report.
Wiener klinische WochenschriftResection of a Giant Middle Mediastinal Tumor Using a Transaortopulmonary Arterial Approach.
Annals of thoracic surgery short reportsNocardia farcinica as a potential pathogen associated with a clinical subtype of Kikuchi-Fujimoto disease.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaNeurological Peculiarities of POEMS Syndrome: Experience From a Brazilian University Center.
Muscle & nerveA case of Takayasu arteritis with advanced macrovascular lesions due to 6 years from onset to diagnosis.
Pediatrics international : official journal of the Japan Pediatric SocietyRadiation Therapy for Benign Diseases and Premalignant Conditions.
Seminars in radiation oncologyUnicentric Castleman disease with paraneoplastic pemphigus and follicular dendritic cell sarcoma: A case report.
Oncology lettersImaging approach to retroperitoneal vascular tumors: a narrative review.
Abdominal radiology (New York)Castleman Disease in a Child: A Rare Cause of Persistent Cervical Lymphadenopathy.
CureusPotential link between COVID-19 infection/vaccination and the onsets of TAFRO syndrome and idiopathic multicentric castleman disease.
Immunology lettersFollicular Dendritic Cell Sarcoma Complicated With Preeclampsia and Fetal Growth Restriction in Pregnancy.
Case reports in medicineOligocentric Castleman disease: clinical characteristics and surgical outcomes from a single-centre retrospective study.
Frontiers in immunologySiltuximab monotherapy improves progression free survival compared to rituximab-based therapies in patients with idiopathic multicentric Castleman disease; indirect comparison of studies using single-arm metanalysis method and the generalized linear mixed model.
Annals of hematologyCharacteristics of rare diseases cases: A summary analysis of hospitalized patients at a hospital in Western China from 2015 to 2023.
Intractable & rare diseases researchKSHV Acquired During Chemsex With Resultant Multicentric Castleman's Disease in a Patient Successfully Treated for HIV.
Journal of medical virologyClinicopathological features differentiating Castleman Disease from IgG4-related ophthalmic disease, a 10 years retrospective study.
Indian journal of ophthalmologyORF45-induced Filamin A phosphorylation promotes cell motility and cell-contact dependent viral infection of Kaposi's sarcoma-associated herpesvirus.
PLoS pathogensUse of tocilizumab to treat IgA nephropathy complicated by idiopathic multicentric Castleman disease: a case report.
BMC nephrologyIgG4 plasma cells in hematopathology: beyond IgG4-related disease.
Journal of hematopathologyPrimary hyaline vascular Castleman disease in the kidney: a report and brief literature review.
Journal of hematopathologyA case of KSHV/HHV8-positive large B-cell lymphoma in a background of HIV-negative KSHV/HHV8-positive Multicentric Castleman disease.
Journal of infection and chemotherapy : official journal of the Japan Society of ChemotherapyHeterogeneous Presentations of iMCD: A Single-Institution Case Series.
Case reports in hematology[A case of unicentric chest wall Castleman disease-associated paraneoplastic autoimmune multiorgan syndrome].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseasesUnicentric Castleman disease in intraparotid lymph node: a case report.
Maxillofacial plastic and reconstructive surgeryA case of systemic lupus erythematosus complicated by TAFRO syndrome-like conditions: analysis of C-X-C motif chemokine ligand 13 and B-cell activating factor dynamics and the efficacy of combination therapy with cyclosporine and belimumab.
Modern rheumatology case reportsAdvances in KSHV Research: Molecular Pathogenesis, Immune Evasion, and Evolving Therapeutic Horizon.
Journal of medical virologyClinical Presentation, Treatment, and Outcomes of 28 Patients With Castleman Disease: A Retrospective Analysis of an Italian Cohort.
EJHaemInterleukin-6 in Castleman disease subtypes: look to tissues, not just blood.
HaematologicaComparative Safety of Tocilizumab and Siltuximab in Castleman Disease: Pharmacovigilance Study.
American journal of hematologyPlasma Cell Predominance in Lichen Planus Pigmentosus: A Rare Case in a Young Female.
Clinical, cosmetic and investigational dermatologyIptacopan in C5 blockade refractory atypical hemolytic uremic syndrome with associated Castleman's disease: case report.
BMC nephrologyDiagnostic Challenges in HHV-8-Associated Multicentric Castleman Disease in a Patient with Prior Kaposi Sarcoma.
Dermatopathology (Basel, Switzerland)Diagnostic and therapeutic challenges in hyaline-vascular idiopathic multicentric Castleman disease: A case report.
The Journal of international medical researchUnicentric Castleman disease presenting as a right lung mass in an 18-year-old man.
ThoraxThe heterogeneity of thoracic Castleman disease: implications for classification and personalized management.
Annals of hematologyEffectiveness and safety of tocilizumab, an anti-interleukin-6 receptor antibody, in 342 Japanese patients with multicentric Castleman disease: a 3-year, prospective, observational study.
Modern rheumatologyBronchiolitis Obliterans in Unicentric Castleman Disease Without Paraneoplastic Pemphigus Requiring Bilateral Lung Transplantation.
CureusAnterior mediastinal lesions in TAFRO syndrome: potential clinical significance.
Rheumatology (Oxford, England)Multicentric Castleman disease detected during the evaluation of tongue cancer: A case report.
Oncology lettersMesenteric Vessel-Preserving Laparoscopic Surgery for Pediatric Unicentric Castleman Disease in the Transverse Mesocolon.
Surgical case reportsPerformance of Large Language Models in Diagnosing Rare Hematologic Diseases and the Impact of Their Diagnostic Outputs on Physicians: Combined Retrospective and Prospective Study.
Journal of medical Internet researchFrom the archives of MD Anderson Cancer Center: Stroma-rich hyaline vascular Castleman disease followed by indolent T-lymphoblastic proliferation and detection of PDGFRB mutation.
Annals of diagnostic pathologyTafro syndrome: early combination therapy outcomes and prolonged thrombocytopenia-a seven-case series.
Modern rheumatologyTime to redefine HHV-8 MCD and KICS criteria?
Blood advancesA challenging case of angioproliferative Castleman's disease in the mediastinum.
Respiratory medicine case reportsPractical Imaging Approach to Determining the Cause of Nonneoplastic Lymphadenopathy.
Radiographics : a review publication of the Radiological Society of North America, Inc[Recent advances in TAFRO syndrome and Castleman disease].
[Rinsho ketsueki] The Japanese journal of clinical hematologyUnicentric Castleman disease in the left adrenal region: a case report and literature review.
Frontiers in oncologyMorphological and quantitative CT features of anterior mediastinal lesions in TAFRO syndrome and idiopathic multicentric Castleman disease.
Frontiers in immunology[Weight loss, fever and abdominal pain in a 58 year-old man].
La Revue de medecine interneThe sonographic characteristics of unicentric castleman disease - a single-center retrospective study.
Cancer imaging : the official publication of the International Cancer Imaging SocietyUnicentric Subcutaneous Hyaline Vascular Castleman Disease With Concurrent Features of Calcifying Fibrous Tumor.
The American Journal of dermatopathologyIsolated Hilar Mass in Unicentric Castleman Disease: Surgery As the Definitive Diagnosis and Treatment.
CureusCastleman Disease and Kaposi Sarcoma: A Review of the Literature and a Case Series.
Journal of clinical medicineCastleman Disease Variant POEMS Syndrome Presenting as Polyradiculoneuropathy in a Child: A Case Report.
Journal of child neurologyALK-Rearranged Mesenchymal Neoplasm With Hyaline-Vascular Castleman Disease-Like Features: A Case Report.
Pathology internationalFerritin, C-Reactive Protein, and Soluble CD25 Distinguish TAFRO From HLH.
American journal of hematologyPerioperative Efgartigimod treatment for acute myasthenia gravis exacerbation with retroperitoneal mass: a case report.
BMC neurologyIntrapulmonary Castleman disease mimicking locally advanced primary lung cancer on 18F-FDG PET/CT.
Revista espanola de medicina nuclear e imagen molecularParotid Castleman's disease: A case report and literature review.
Oral oncologyCastleman disease: a case report of a pediatric incidental case in Saudi Arabia.
Journal of surgical case reportsUnraveling the clinicopathological diversity of Castleman disease: report of three cases.
QJM : monthly journal of the Association of PhysiciansSequence variability of the K1 gene in Kaposi's sarcoma-associated herpesvirus and its role in pathogenesis.
Current opinion in virologyRobotic Resection of Parapharyngeal Follicular Dendritic Cell Sarcoma With Castleman Disease.
The LaryngoscopeOrbital Castleman Disease on 18 F-FDG PET/CT.
Clinical nuclear medicineMulticentric Castleman disease with splenic presentation: report of two rare cases with focus on histopathological features and review of the literature.
Virchows Archiv : an international journal of pathologyDistinct interleukin-6 production in IPL and TAFRO subtypes of idiopathic multicentric Castleman disease.
Haematologica[Hyaline vascular Castleman disease with indolent T-lymphoblastic proliferation complicated by paraneoplastic autoimmune multiorgan syndrome: report of a case].
Zhonghua bing li xue za zhi = Chinese journal of pathologyAtypical clinical presentation associated with Castleman disease: a case report and review of the literature.
Frontiers in medicineUnicentric Castleman disease treated with rituximab before surgery: clinicopathologic findings.
Annals of hematologyHIV-associated multicentric Castleman disease with Kaposi sarcoma: A case report with 120-week follow-up of HHV-8 after remission.
Journal of infection and chemotherapy : official journal of the Japan Society of ChemotherapyCastleman disease with synchronous primary rectal and prostate cancers: a case report of successful multimodal treatment and 2-year recurrence-free survival.
Frontiers in oncologyAbdominal Unicentric Castleman Disease: A Hepato-Pancreatico-Biliary Frenemy.
CureusPre-existing oncohematological disease in kidney transplant recipients: impact on graft survival, acute rejection, and long-term clinical outcomes.
Frontiers in immunologyThe Evolution and Recent Advances in Diagnostic Criteria for Idiopathic Multicentric Castleman Disease.
American journal of hematologyOncogenic Mechanisms of Kaposi's Sarcoma-Associated Herpesvirus on Cell Metabolism and Cell Transformation.
Journal of medical virologyUnicentric Hyaline-Vascular Castleman Disease Presenting as a Periduodenal Mass: A Rare Retroperitoneal Manifestation.
CureusLung transplantation in a patient with severe bronchiolitis obliterans secondary to Castleman disease.
Respiratory medicine case reportsA patient-derived CABIN1 mutation recapitulates features of idiopathic multicentric Castleman disease in a mouse model.
Blood advancesSuccessful tocilizumab monotherapy for multicentric Castleman disease complicated by rheumatoid arthritis and Sjögren's disease: a case-based literature review.
Immunological medicineIdiopathic multicentric Castleman disease with TAFRO syndrome: A rare case report.
Indian journal of cancerGiant Coronary Artery Aneurysm in a Patient With Castleman Disease.
JACC. Case reportsStriking effectiveness of siltuximab-based treatment in refractory idiopathic multicentric Castleman disease resembling IgG4-related disease.
Journal of chemotherapy (Florence, Italy)Characteristics and outcomes of Kaposi sarcoma herpesvirus-associated inflammatory cytokine syndrome.
Blood advancesEXT1/EXT2-Associated Membranous Nephropathy Secondary to TAFRO Syndrome: A Case Report.
NephronTreatment of Idiopathic Multicentric Castleman's Disease With Sequential Thalidomide-Cyclophosphamide-Prednisone After Siltuximab:Report of One Case.
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae SinicaeIdiopathic multicentric Castleman disease resembling autoimmune diseases: A case report.
MedicineMulticentric Castleman disease presenting with orbital involvement progressing to TAFRO syndrome: a case report.
BMC ophthalmologyClinical features and management of head and neck castleman disease: a single-center retrospective analysis.
Acta oto-laryngologicaRetroperitoneal unicentric hyaline vascular variant of Castleman's disease: a case report.
Journal of surgical case reportsThe morphological spectrum of Castleman disease and related disorders: a report from the Lymphoma Workshop of the 22nd Meeting of the European Association of Hematopathology.
Virchows Archiv : an international journal of pathologyComplications and Management of Idiopathic Multicentric Castleman Disease.
HCA healthcare journal of medicineUnicentric Castleman disease following POEMS syndrome remission.
Journal of hematopathologyFollicular dendritic cell sarcoma of the stomach in a young male: A rare case report and literature review.
Medicine[Clinical Characteristic of Castleman Disease with Renal and Orbit Involvement].
Zhongguo shi yan xue ye xue za zhiCurative Gastrectomy for Advanced Gastric Cancer in a Patient with Idiopathic Multicentric Castleman Disease: A Rare Case Report.
Surgical case reportsPathologic Findings of Pulmonary Lymphoproliferative Disorders.
Seminars in ultrasound, CT, and MRInterferon-γ sparks inflammatory fire in Castleman disease.
BloodLymphoproliferative Disorders Mimicked by Tuberculosis: A Retrospective Study on Lateral Flow Urine Lipoarabinomannan (LF-ULAM) Limitations.
CureusSpatial and single cell mapping of castleman disease reveals key stromal cell types and cytokine pathways.
Nature communicationsA case report of Castleman disease variant of POEMS syndrome presenting with prominent polyserositis and renal impairment.
Frontiers in medicineSurgical approach to posterior mediastinal Castleman´s disease: a case report.
The Pan African medical journalAn unicentric Castleman disease in the hepatopancreatic space.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractInternational Consensus Histopathological Criteria for Subtyping Idiopathic Multicentric Castleman Disease Based on Machine Learning Analysis.
American journal of hematologyConcurrent Presentation of Human Herpesvirus 8-Associated Multicentric Castleman Disease and Kaposi Sarcoma in a Young Patient.
CureusParaneoplastic Limbic Encephalitis in a Patient With Thymoma.
CureusNon-Clonal Lymphoproliferative Diseases.
Hematological oncology[A case of pulmonary nodules and cysts associated with hypereosinophilia].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases[Sequential treatment with siltuximab and tocilizumab for childhood idiopathic multicentric Castleman disease: a case report].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsHemophagocytic lymphohistiocytosis in people living with HIV-a single centre experience.
Infection18F-FDG PET/CT of a Multicentric Castleman Disease with Lymph Node and Skin Involvement.
Molecular imaging and radionuclide therapyExpert Perspective: Diagnosis and Treatment of Castleman Disease.
Arthritis & rheumatology (Hoboken, N.J.)Unicentric Castleman disease: CT and cinematic rendering imaging features.
Diagnostic and interventional imagingClinical Utility of an Increased Pretreatment Immature Platelet Fraction in the Early Diagnosis of TAFRO Syndrome, Especially in Patients with Late-onset Thrombocytopenia: A Case Series and Literature Review.
Internal medicine (Tokyo, Japan)Diagnostic pitfall: Castleman's disease versus systemic lupus erythematosus in a woman with generalised lymphadenopathy.
BMJ case reports[Pulmonary Castleman disease: At the crossroads of thoracic and hematologic pathology].
Annales de pathologieKaposi sarcoma and Kaposi inflammatory cytokine syndrome following allogeneic haematopoietic stem cell transplantation: A case report.
British journal of haematologyEfficacy of High-Dose Intravenous Anakinra in Pediatric TAFRO Syndrome: Report of Two Cases and Literature Review.
Pediatric blood & cancerExploring castleman disease in a cohort of hispanic patients: a recognition to its histopathology.
Journal of hematopathologyAutoantibodies Directed Against Insulin Receptor During the Course of Castleman Disease: A New Case Reaffirming Autoimmune Hypoglycemia as a Relapse Warning Signal.
European journal of case reports in internal medicineSurvival and Hospital Discharge Achieved Through Intensive Circulatory, Fluid, and Respiratory Support in Severe TAFRO (Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis, and Organomegaly) Syndrome With Multiorgan Dysfunction: A Case Report.
Cureus[Breast implant-associated anaplastic large cell lymphoma that developed 20 years after breast reconstruction and was successfully treated with chemotherapy].
[Rinsho ketsueki] The Japanese journal of clinical hematologyKaposi Sarcoma-Associated Herpesvirus Risk and Disease in Kidney Donors and Transplant Recipients with HIV in the United States.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaRare Disease Drug Repurposing.
JAMA network openRare Unicentric Intrapulmonary Castleman Disease: A Systematic Review and Report of a Case.
The open respiratory medicine journalPrognostic value of serum C-reactive protein in idiopathic multicentric Castleman disease and construction of a prognostic model for patients.
Frontiers in medicineIsolated involvement of parotid in unicentric Castleman disease.
BMJ case reportsReversible cerebral vasoconstriction syndrome in idiopathic multicentric Castleman disease under treatment with tocilizumab.
BMJ neurology openLaboratory Characterization of Co-Infections in Individuals Infected with HHV-8.
VirusesCastleman Disease-Still More Questions than Answers: A Case Report and Review of the Literature.
Journal of clinical medicineThe Involvement of PI3K-Akt Signaling in the Clinical and Pathological Findings of Idiopathic Multicentric Castleman Disease-Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis, and Organomegaly and Not Otherwise Specified Subtypes.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, IncUnmasking POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes) Syndrome in a Heart Failure Patient: A Diagnostic Challenge.
CureusEfficacy of tocilizumab monotherapy for autoimmune hemolytic anemia associated with idiopathic multicentric Castleman disease: a case-based review.
Rheumatology internationalCastleman disease of stomach treated by endoscopic submucosal dissection: a case report and literature review.
Frontiers in oncologySuccessful Treatment of Refractory TAFRO Syndrome with Cyclophosphamide: A Report of Two Cases.
Internal medicine (Tokyo, Japan)Spatial transcriptomics study of Castleman disease.
Journal of translational medicineAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Mesenteric unicentric Castleman's disease misdiagnosed as gastrointestinal neuroendocrine tumour.
- Snapshot Look at Castleman Disease.
- Monoclonal neutralizing antibodies elicited by infection with Kaposi sarcoma-associated herpesvirus reveal critical sites of vulnerability on gH/gL.
- Comprehensive analysis of subtype-specific outcomes and management in Castleman disease: a 20-year cohort study.
- Unicentric Castleman Disease as a Sufficient and Reversible Cause of Steroid-Refractory Autoimmune Hemolytic Anemia in a Child.
- Morphological characteristics of the renal lesion in TAFRO syndrome and POEMS syndrome: a retrospective and multicenter study.
- Deciphering the full spectrum of Castleman diseases based on a cohort of 700 patients in a western country.
- Efficacy and safety of steroid-sparing strategy in the treatment of AIHA associated with KSHV/HHV-8 positive multicentric Castleman disease.
- Hyaline Vascular Castleman Disease Presenting as Occipital Scalp Swelling in a Child.
- A rare case of unicentric Castleman disease in the posterior mediastinum: case report and integrated literature review.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:160(Orphanet)
- MONDO:0015564(MONDO)
- GARD:12656(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q1947302(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
