Uma forma da Doença de Castleman multicêntrica, caracterizada por: plaquetas baixas no sangue, acúmulo de líquido na barriga (barriga d'água) e inchaço generalizado, anemia com glóbulos vermelhos pequenos, endurecimento da medula óssea, problemas nos rins e aumento do tamanho de órgãos.
Introdução
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Uma forma da Doença de Castleman multicêntrica, caracterizada por: plaquetas baixas no sangue, acúmulo de líquido na barriga (barriga d'água) e inchaço generalizado, anemia com glóbulos vermelhos pequenos, endurecimento da medula óssea, problemas nos rins e aumento do tamanho de órgãos.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
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+ 12 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 27 características clínicas mais associadas, ordenadas por frequência.
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Genética e causas
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Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
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🇧🇷 Atendimento SUS — Síndrome TAFRO
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Publicações mais relevantes
Recovery trajectories of TAFRO syndrome: a single-center case series highlighting prolonged thrombocytopenia and anasarca.
TAFRO syndrome is a rare systemic inflammatory disorder characterized by thrombocytopenia, anasarca, fever or inflammation, reticulin fibrosis or renal dysfunction, and organomegaly. Despite increasing recognition, its natural history, particularly the timeline of organ-specific recovery, remains poorly understood. We retrospectively analyzed seven patients, encompassing nine treatment courses, diagnosed with TAFRO syndrome at our institution. Time to recovery was assessed across four clinical domains-renal dysfunction, systemic inflammation, anasarca, and thrombocytopenia-using predefined objective criteria. The median time to recovery was 7.0 days for renal dysfunction, 21.0 days for systemic inflammation, 24.0 days for anasarca, and 46.0 days for thrombocytopenia. Recovery of thrombocytopenia and anasarca tended to be delayed compared with that of renal dysfunction and systemic inflammation, with thrombocytopenia showing the longest median time to recovery. These findings indicate substantial heterogeneity in organ-specific recovery trajectories in TAFRO syndrome, with hematologic and fluid-related manifestations resolving more slowly than inflammatory or renal abnormalities. Recognition of domain-specific recovery timelines may aid interpretation of treatment responses and support more balanced, individualized management strategies.
The value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the diagnosis and evaluation of TAFRO syndrome: a review of cases and literature.
This retrospective case series intends to summarise the 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) imaging characteristics of TAFRO syndrome, providing imaging evidence for its clinical diagnosis and differential diagnosis to enhance early diagnostic accuracy and improve patient prognosis. A retrospective analysis was conducted on the 18F-FDG PET/CT images and clinical data of 5 patients with TAFRO syndrome (3 males and 2 females, with an average age of 51.4 (39-58) years). Combined with domestic and international literature, the value of 18F-FDG PET/CT in the diagnosis and evaluation of TAFRO syndrome was summarised. All the cases were diagnosed as multicentric Castleman disease (MCD) and all showed typical imaging manifestations of TAFRO syndrome. The size of the affected lymph nodes and the maximum standardised uptake value (SUVmax) of the patients were measured. It was found that all showed varying degrees of enlargement accompanied by increased 18F-FDG metabolism (SUVmax > 2.5). In addition, spleen length was measured in the craniocaudal dimension for all patients and it was found that 2 patients had significant enlargement. Based on the analysis of the PET/CT images of the patients, the bone marrow showed varying degrees of metabolic activity, and pleural effusions and ascites were clearly identifiable. 18F-FDG PET/CT imaging, as a functional metabolic imaging technique, can detect metabolic abnormalities at the sub-centimetre level. Moreover, a single examination can cover the entire body, enabling better detection of occult lesions and providing significant assistance in the diagnosis and assessment of TAFRO syndrome.
Concurrent Idiopathic Multicentric Castleman Disease with TAFRO and Sjögren's Syndrome in a Young Patient: A Challenging Diagnostic Overlap.
Idiopathic multicentric Castleman disease (iMCD) with TAFRO syndrome (characterized by thrombocytopenia, anasarca, fever, reticulin fibrosis/renal failure, organomegaly) is a recently described disorder. The diagnostic criteria for iMCD-TAFRO exclude patients with concomitant autoimmune diseases such as primary Sjögren's syndrome. However, recent case reports suggest that although rare, these conditions may coexist. We report the case of a 37-year-old woman who presented with escalating systemic inflammation, cytopenias, anasarca, renal dysfunction and organomegaly, with lymph node biopsy suggestive of Castleman disease. Simultaneously, dense lacrimal gland hyperplasia with histopathology demonstrating lymphoepithelial sialadenitis and strongly positive anti-Ro52 antibodies led to a diagnosis of Sjögren's syndrome. Given the rapid clinical deterioration and marked hyperinflammation, corticosteroid therapy and tocilizumab were implemented, leading to sustained remission. This case illustrates the diagnostic complexity posed by overlapping features of Idiopathic multicentric Castleman disease with TAFRO syndrome and Sjögren's syndrome and reinforces the need to reconsider existing diagnostic criteria to ensure timely diagnosis and effective treatment. Epidemiologically, this is also a rare case of iMCD with TAFRO syndrome in a patient of African descent, contrasting with previous reports predominantly involving Asian individuals. Idiopathic multicentric Castleman disease (iMCD) with TAFRO syndrome (thrombocytopenia, anasarca, fever, reticulin fibrosis/renal failure, organomegaly) (iMCD-TAFRO) is a rare, life-threatening disorder marked by severe systemic inflammation and multiorgan failure, and early recognition and timely initiation of immunomodulatory therapy are critical for positive outcomes.Although current diagnostic criteria for iMCD-TAFRO exclude patients with concomitant autoimmune diseases such as Sjögren's syndrome, an increasing number of case reports suggest that these conditions may coexist, challenging existing definitions and suggesting a potential physiopathological overlap.This case highlights the diagnostic challenge posed by the coexistence of these conditions and underscores the need for an individualized assessment integrating clinical, laboratory, and immunological findings.
Correction: TAFRO syndrome requiring combined IL 6 and IL 1 inhibition: a case report.
[This corrects the article DOI: 10.3389/fimmu.2025.1729525.].
Ruxolitinib in relapsed/refractory TAFRO syndrome: a report of two cases, including one positive for Epstein-Barr virus, and a literature review.
TAFRO syndrome is a rare systemic inflammatory disorder characterized by thrombocytopenia, anasarca, fever, reticulin fibrosis, renal dysfunction, and organomegaly. Its pathogenesis remains elusive, and its non-specific symptoms overlap with idiopathic multicentric Castleman disease, complicating its management. This report discusses two cases of TAFRO syndrome resistant to conventional treatments, including corticosteroids, tocilizumab, and rituximab. Both patients showed significant clinical improvement after treatment with ruxolitinib, a JAK-STAT pathway inhibitor. The first patient was a 55-year-old man who showed clinical improvement with ruxolitinib after the failure of multiple lines of treatment, including corticosteroids, tocilizumab, rituximab, and cyclosporin A. The second was another 55-year-old man who experienced disease relapse 18 months after initial treatment but responded rapidly to ruxolitinib. These cases highlight the potential role of ruxolitinib as a therapeutic option for refractory TAFRO syndrome. In addition, Epstein-Barr virus (EBV) DNA was detected in the serum of the first patient, making this the first report to demonstrate the effectiveness of ruxolitinib in EBV-associated TAFRO syndrome. These findings highlight the need for further studies to confirm the efficacy of ruxolitinib in such cases and elucidate the pathophysiological mechanisms underlying TAFRO syndrome, which could guide future therapeutic strategies.
Publicações recentes
Successful Treatment of Refractory Pediatric TAFRO Syndrome With Combination Chemotherapy: A Case Report.
Ultrasound-guided lateral kidney biopsy in patients unsuitable for the prone position.
🥉 Relato de casoMorphological characteristics of the renal lesion in TAFRO syndrome and POEMS syndrome: a retrospective and multicenter study.
[The 516th case: hyperinflammatory state, acute renal dysfunction, hepatosplenomegaly with lymphadenopathy, and recurrent cerebral infarctions].
Primary adrenal insufficiency and autoimmune thyroiditis in an adolescent with Castleman-TAFRO syndrome.
📚 EuropePMC250 artigos no totalmostrando 194
Recovery trajectories of TAFRO syndrome: a single-center case series highlighting prolonged thrombocytopenia and anasarca.
Immunological medicineThe value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the diagnosis and evaluation of TAFRO syndrome: a review of cases and literature.
Clinical radiologyConcurrent Idiopathic Multicentric Castleman Disease with TAFRO and Sjögren's Syndrome in a Young Patient: A Challenging Diagnostic Overlap.
European journal of case reports in internal medicineMulticentric Castleman disease (MCD) presenting with retiform purpura: A rare dermatologic manifestation of a systemic disease.
JAAD case reportsTAFRO syndrome requiring combined IL 6 and IL 1 inhibition: a case report.
Frontiers in immunologyRuxolitinib in relapsed/refractory TAFRO syndrome: a report of two cases, including one positive for Epstein-Barr virus, and a literature review.
International journal of hematologyPotential link between COVID-19 infection/vaccination and the onsets of TAFRO syndrome and idiopathic multicentric castleman disease.
Immunology lettersPolyarteritis nodosa presenting with TAFRO signs following COVID-19 infection: case report.
Modern rheumatology case reportsHeterogeneous Presentations of iMCD: A Single-Institution Case Series.
Case reports in hematologyA case of systemic lupus erythematosus complicated by TAFRO syndrome-like conditions: analysis of C-X-C motif chemokine ligand 13 and B-cell activating factor dynamics and the efficacy of combination therapy with cyclosporine and belimumab.
Modern rheumatology case reportsEffective Treatment with Ruxolitinib and Ropeginterferon Alfa-2b for Refractory TAFRO-like Syndrome.
Internal medicine (Tokyo, Japan)Anterior mediastinal lesions in TAFRO syndrome: potential clinical significance.
Rheumatology (Oxford, England)Tafro syndrome: early combination therapy outcomes and prolonged thrombocytopenia-a seven-case series.
Modern rheumatology[Recent advances in TAFRO syndrome and Castleman disease].
[Rinsho ketsueki] The Japanese journal of clinical hematologyMorphological and quantitative CT features of anterior mediastinal lesions in TAFRO syndrome and idiopathic multicentric Castleman disease.
Frontiers in immunology[Weight loss, fever and abdominal pain in a 58 year-old man].
La Revue de medecine interneTAFRO Syndrome-A Decade Later, Still Racing Against Time.
BiomedicinesIdiopathic multicentric Castleman disease with TAFRO syndrome: A rare case report.
Indian journal of cancerEXT1/EXT2-Associated Membranous Nephropathy Secondary to TAFRO Syndrome: A Case Report.
NephronThrombocytopenia, anasarca, fever, reticulum fibrosis, and organomegaly syndrome triggered by vaccination against SARS-CoV-2 messenger RNA vaccine.
Modern rheumatology case reportsMulticentric Castleman disease presenting with orbital involvement progressing to TAFRO syndrome: a case report.
BMC ophthalmologyThe morphological spectrum of Castleman disease and related disorders: a report from the Lymphoma Workshop of the 22nd Meeting of the European Association of Hematopathology.
Virchows Archiv : an international journal of pathology[Sequential treatment with siltuximab and tocilizumab for childhood idiopathic multicentric Castleman disease: a case report].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsClinical Utility of an Increased Pretreatment Immature Platelet Fraction in the Early Diagnosis of TAFRO Syndrome, Especially in Patients with Late-onset Thrombocytopenia: A Case Series and Literature Review.
Internal medicine (Tokyo, Japan)Efficacy of High-Dose Intravenous Anakinra in Pediatric TAFRO Syndrome: Report of Two Cases and Literature Review.
Pediatric blood & cancerSurvival and Hospital Discharge Achieved Through Intensive Circulatory, Fluid, and Respiratory Support in Severe TAFRO (Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis, and Organomegaly) Syndrome With Multiorgan Dysfunction: A Case Report.
CureusA Series of Glomerular Diseases That Developed After COVID-19 Vaccination.
CureusSuccessful Treatment of Refractory TAFRO Syndrome with Cyclophosphamide: A Report of Two Cases.
Internal medicine (Tokyo, Japan)Case Report: TAFRO syndrome misdiagnosed as liver cirrhosis due to persistent abdominal distension.
Frontiers in immunologySuccessful Treatment of TAFRO (Thrombocytopenia, Anasarca, Fever, Renal Insufficiency, and Organomegaly) Syndrome With Triple Combination Therapy of Corticosteroid, Tocilizumab, and Cyclosporine: A Case Report.
CureusFirst-line treatment of TAFRO syndrome with rituximab: a case report and literature review.
Annals of hematologySystemic sclerosis presenting TAFRO syndrome-like manifestations including renal glomerular microangiopathy: a case report and literature review.
Immunological medicineTAFRO Syndrome with Massive Bilateral Adrenal Hemorrhage.
Internal medicine (Tokyo, Japan)TAFRO Syndrome Without Pathology Supporting Castleman Disease: To Be Treated as Idiopathic Multicentric Castleman Disease-TAFRO or a Distinct Disease Entity?
Turkish journal of haematology : official journal of Turkish Society of HaematologyMyelodysplastic neoplasms with repeating TAFRO syndrome-like symptoms.
International journal of hematologyExploring the Clinical Diversity of Castleman Disease and TAFRO Syndrome: A Japanese Multicenter Study on Lymph Node Distribution Patterns.
American journal of hematologyComputed tomography findings of idiopathic multicentric Castleman disease subtypes.
Journal of clinical and experimental hematopathology : JCEHCase report: Atypical POEMS syndrome without polyneuropathy, complicated by borderline TAFRO syndrome.
Frontiers in medicineRenal involvement in TAFRO syndrome: a review.
Clinical and experimental nephrologyPathophysiology, Treatment, and Prognosis of Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis/Renal Failure, and Organomegaly (TAFRO) Syndrome: A Review.
Current issues in molecular biologyPeculiar hyper vascular manifestations in idiopathic multicentric castleman disease without tafro syndrome: a case report.
Annals of hematologyCastleman Disease: A Rare Lymphoproliferative Disorder With Diverse Clinical Presentation, Diagnosis, and Treatment Approach.
CureusAn Unusual Case of HHV-8 Negative, Idiopathic, Multicentric Castleman Disease Following Chronic Lymphocytic Leukaemia.
European journal of case reports in internal medicineTAFRO syndrome with abdominal pain as the first symptom accompanied by liver damage with hyperbilirubinemia: A case report.
HeliyonTAFRO-like Symptoms in a Sjögren's Syndrome Patient with HTLV-1 Infection.
Internal medicine (Tokyo, Japan)Epstein-Barr virus-encoded RNA-positive lymphocytes in bone marrow and lymph nodes in an autopsy case of TAFRO syndrome.
Modern rheumatology case reportsIdiopathic multicentric Castleman disease-TAFRO after COVID-19: A case report.
Modern rheumatology case reportsDelayed diagnosis of TAFRO syndrome: A case report.
MedicinePediatric TAFRO syndrome: A multi-institution case series illustrating clinical challenges and excellent outcomes.
Pediatric blood & cancerComparison of pathophysiological differences in TAFRO syndrome with or without lymphadenopathy.
Journal of clinical and experimental hematopathology : JCEHIdiopathic Multicentric Castleman Disease With Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis/Renal Insufficiency, and Organomegaly (TAFRO) Syndrome in a Liver Transplant Recipient.
ACG case reports journalLong-term clinicopathological characteristics of TAFRO syndrome and its relapse: a case series study.
Clinical kidney journalRecurrent Cerebral Hemorrhaging with Platelet Dysfunction Accompanied by Anti-glycoprotein VI Autoantibodies in a Patient with TAFRO Syndrome.
Internal medicine (Tokyo, Japan)TAFRO Syndrome and COVID-19.
BiomedicinesTAFRO Syndrome: Guidance for Managing Patients Presenting Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis, Renal Insufficiency, and Organomegaly.
BiomedicinesBiomarkers and Signaling Pathways Implicated in the Pathogenesis of Idiopathic Multicentric Castleman Disease/Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis, Renal Insufficiency, and Organomegaly (TAFRO) Syndrome.
BiomedicinesDysmorphic megakaryocytes in TAFRO syndrome: A case series from a single institute.
Blood cells, molecules & diseasesA case of TAFRO syndrome after vaccination, successfully treated with cyclosporine.
BMC nephrologyUnraveling TAFRO Syndrome: An In-Depth Look at the Pathophysiology, Management, and Future Perspectives.
BiomedicinesTacrolimus Treatment for TAFRO Syndrome.
BiomedicinesTAFRO Syndrome on 18F-FDG-PET/CT: An Appealing Diagnostic Tool.
Diagnostics (Basel, Switzerland)A Case of Thrombocytopenia, Anasarca (Edema, Pleural Effusion, and Ascites), Fever, Reticulin Fibrosis/Renal Dysfunction, and Organomegaly (TAFRO) Syndrome Initially Not Presenting With Thrombocytopenia: A Role of Immature Platelet Fraction.
CureusDifferentiation Between Disseminated Carcinomatosis of the Bone Marrow From Urothelial Cancer and Intravascular Large B-cell Lymphoma: A Case Report.
Cureus[Improvement of tissue fibrosis in TAFRO syndrome by prednisolone monotherapy].
[Rinsho ketsueki] The Japanese journal of clinical hematologyInvestigation of the Effect of Therapeutic Plasma Exchange for TAFRO Syndrome: A Pilot Study.
BiomedicinesRadiological Imaging Findings of Adrenal Abnormalities in TAFRO Syndrome: A Systematic Review.
BiomedicinesTAFRO Syndrome: A Syndrome or a Subtype of Multicentric Castleman Disease?
BiomedicinesPotential risks of cell-free concentrated ascites reinfusion therapy in TAFRO syndrome patient.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis TherapyTAFRO syndrome is associated with anti-SSA/Ro60 antibodies, in contrast to idiopathic castleman disease.
Scientific reportsSuccessful treatment of streptococcal toxic shock syndrome complicated by primary peritonitis and bilateral empyema in a healthy young woman: Identification of uncommon clone emm103 and novel sequence type 1363.
IDCasesPeritoneal dialysis is feasible for TAFRO syndrome with acute kidney injury and refractory ascites: A case report.
Clinical nephrologyA Case of TAFRO Syndrome Developed after COVID-19 Vaccination.
Case reports in nephrologyTAFRO syndrome in an adolescent with acute hepatitis-like imaging findings.
Pediatrics international : official journal of the Japan Pediatric Society[Clinical Anslysis of TAFRO Syndrome].
Zhongguo shi yan xue ye xue za zhiStepwise Treatment for TAFRO Syndrome.
Journal of medical casesCase Report: A case of TAFRO syndrome with severe and prolonged thrombocytopenia: diagnostic pitfalls.
Frontiers in immunologyCase report: A case of acute exacerbation of interstitial pneumonia associated with TAFRO syndrome.
Frontiers in medicineThe experience of diagnosis and treatment for TAFRO syndrome.
Annals of hematologyThrombocytopenia, Anasarca, Myelofibrosis, Renal dysfunction, and Organomegaly (TAFRO) Syndrome Initially Diagnosed as Fibromyalgia: A Case Report.
CureusCase report: Rehabilitation course in thrombocytopenia, anasarca, fever, reticulin fibrosis/renal failure, and organomegaly syndrome complicated by cerebral infarction in the left parabolic coronary region.
Frontiers in neurologyRituximab-bortezomib-dexamethasone induce high response rates in iMCD in clinical practice.
British journal of haematologyAutopsy-proven anaplastic large cell lymphoma mimicking TAFRO syndrome.
Pediatrics international : official journal of the Japan Pediatric SocietyA case of TAFRO syndrome with DIC and neurologic and cardiac involvement.
Clinical case reports[Successful rituximab treatment of TAFRO syndrome refractory to glucocorticoids and tocilizumab].
[Rinsho ketsueki] The Japanese journal of clinical hematologyCombined B-cell immunomodulation with rituximab and belimumab in severe, refractory TAFRO syndrome associated with Sjögren's syndrome: A case report.
Modern rheumatology case reportsSevere systemic inflammation mimicking TAFRO syndrome following COVID-19.
International journal of hematologyDevelopment of rapidly fatal TAFRO syndrome-like features in a patient with essential thrombocythemia.
Journal of clinical and experimental hematopathology : JCEHEpstein-Barr Virus-Positive Cutaneous and Systemic Plasmacytosis with TAFRO Syndrome-like Symptoms Successfully Treated with Rituximab.
Medicina (Kaunas, Lithuania)Thrombocytopenia, anasarca, and renal insufficiency as severe and rare complications of Hodgkin lymphoma: a case report.
Journal of medical case reportsTAFRO syndrome was effectively treated with an inexpensive novel scheme: A case report.
Clinical case reportsEvaluation of the correlation between multiple organ calcification on CT and disease severity in patients with TAFRO syndrome.
Japanese journal of radiologySevere TAFRO Syndrome Mimicking Hepatorenal Syndrome Successfully Treated with a Multidisciplinary Approach: A Case Report and Literature Review.
Internal medicine (Tokyo, Japan)Siltuximab Monotherapy in Tafro Syndrome: A Case Report and Review of the Literature.
Journal of nephrologyAdolescent-onset TAFRO Syndrome with Malignant Nephrosclerosis-like Lesions.
Internal medicine (Tokyo, Japan)Treatment-resistant idiopathic multicentric Castleman disease with thrombocytopenia, anasarca, fever, reticulin fibrosis, renal dysfunction, and organomegaly managed with Janus kinase inhibitors: A case report.
MedicineIdiopathic Multicentric Castleman Disease Occurring Shortly after mRNA SARS-CoV-2 Vaccine.
VaccinesTAFRO syndrome: A disease that known is half cured.
Hematological oncologyAcute Abdomen and Adrenal Swelling as the First Manifestations of TAFRO Syndrome.
Internal medicine (Tokyo, Japan)Global public awareness of Castleman disease and TAFRO syndrome between 2015 and 2021: A Google Trends analysis.
EJHaemSevere coronavirus disease 2019 in a patient with TAFRO syndrome: A case report.
Clinical infection in practiceTAFRO syndrome with renal biopsy successfully treated with steroids and cyclosporine: a case report.
BMC nephrologyTAFRO syndrome: A severe manifestation of Sjogren's syndrome? A systematic review.
Autoimmunity reviewsIdiopathic plasmacytic lymphadenopathy: A conceptual history along with a translation of the original Japanese article published in 1980.
Journal of clinical and experimental hematopathology : JCEHCastleman disease, TAFRO syndrome, idiopathic plasmacytic lymphadenopathy, and autoimmune disease.
Journal of clinical and experimental hematopathology : JCEHA Rare Variant of Idiopathic Multicentric Castleman Disease: TAFRO Syndrome.
Turkish journal of haematology : official journal of Turkish Society of HaematologyTAFRO Syndrome Treated Effectively with Corticosteroids: A Case Report and Review of the Literature.
Indian journal of nephrologyTAFRO Syndrome: A Disease Requiring Immediate Medical Attention.
Internal medicine (Tokyo, Japan)Successful combination treatment with rituximab, steroid pulse therapy, plasma exchange and romiplostim for very severe TAFRO syndrome.
Leukemia & lymphomaMimic or coincidentally? TAFRO syndrome and systemic lupus erythematosus: A case-based review.
Modern rheumatology case reportsAn autopsy case of TAFRO syndrome with multiple cerebral infarctions caused by small vessel pathology.
eNeurologicalSciMultisystem Inflammatory Syndrome in Children: A Case Report From Japan.
CureusPost-transplant Complication With TAFRO Features in a Patient With Acute Myeloid Leukemia.
CureusInternational definition of iMCD-TAFRO: future perspectives.
Journal of clinical and experimental hematopathology : JCEHHistorical and pathological overview of Castleman disease.
Journal of clinical and experimental hematopathology : JCEHTAFRO syndrome with a fatal clinical course following BNT162b2 mRNA (Pfizer-BioNTech) COVID-19 vaccination: A case report.
Journal of infection and chemotherapy : official journal of the Japan Society of ChemotherapyTAFRO Syndrome That Responded to Prednisolone-only Treatment: Evaluating Changes in IL-6.
Internal medicine (Tokyo, Japan)Abnormal Exacerbation of Moderately Differentiated Gastric Adenocarcinoma in a Patient with TAFRO Syndrome: An Impaired Tumor Immunity?
Case reports in oncologyCastleman disease and TAFRO syndrome: To improve the diagnostic consciousness is the key.
World journal of clinical casesA Case of Oral Glomeruloid Hemangioma Without Systemic Conditions.
CureusA case of TAFRO syndrome maintained in remission for 5 years after discontinuation of tocilizumab.
Modern rheumatology case reportsGlomeruloid Hemangioma in a Patient with TAFRO Syndrome.
Internal medicine (Tokyo, Japan)Castleman disease and TAFRO syndrome.
Annals of hematologyAnti-interferon-γ Antibody-seropositive Disseminated Nontuberculous Mycobacterial Infection Mimicking POEMS and TAFRO Syndromes.
Internal medicine (Tokyo, Japan)TAFRO syndrome with fatigue and abdominal distension as the first symptom: A case report.
Hematological oncologyTo and TAFRO - a cryptic cause of acute renal failure: a case report.
BMC nephrologySuccessful Treatment of Thrombocytopenia, Anasarca, Fever, Reticulin Myelofibrosis/Renal Insufficiency, and Organomegaly Syndrome Using Plasma Exchange Followed by Rituximab in the Intensive Care Unit.
Journal of medical casesRenal histological continuum of TAFRO syndrome: A case report and literature review.
Clinical nephrologyMulticentric Castleman disease and the evolution of the concept.
PathologicaTAFRO Syndrome and Elusive Diagnosis of Idiopathic Multicentric Castleman Disease Treated with Empiric Anti-Interleukin-6 Therapy.
Case reports in oncologyTAFRO Syndrome in a Kidney Transplant Recipient That Was Diagnosed on Autopsy: A Case Report.
Frontiers in medicineCharacteristics of thrombocytopenia, anasarca, fever, reticulin fibrosis and organomegaly syndrome: a retrospective study from a large Western cohort.
British journal of haematologyIntracranial Hemorrhage in a Patient with TAFRO Syndrome Treated with Cyclosporine A and Rituximab.
Medicina (Kaunas, Lithuania)A Case of TAFRO Syndrome With Pulmonary Abnormalities.
Journal of thoracic imagingTAFRO syndrome complicated by porto-sinusoidal vascular liver disease with portal hypertension: a case report.
Clinical journal of gastroenterologyA Patient With Human Herpesvirus 8-Positive Multicentric Castleman's Disease Who Met Criteria for TAFRO Syndrome: Controversy in Practice?
Journal of medical cases[A case report of TAFRO syndrome].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciencesBilateral Adrenal Infarctions as an Initial Manifestation of TAFRO Syndrome: A Case Report and Review of the Literature.
Internal medicine (Tokyo, Japan)Validated international definition of the thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly clinical subtype (TAFRO) of idiopathic multicentric Castleman disease.
American journal of hematologyTAFRO Syndrome with Renal Thrombotic Microangiopathy: Insights into the Molecular Mechanism and Treatment Opportunities.
International journal of molecular sciencesFatal case of TAFRO syndrome with unilateral adrenal hemorrhage in early-stage disease.
Journal of clinical and experimental hematopathology : JCEHTAFRO syndrome presenting as intrahepatic cholangitis on autopsy.
Clinical case reportsPatient's age and D-dimer levels predict the prognosis in patients with TAFRO syndrome.
International journal of hematologyTAFRO Syndrome With Kidney Involvement: A Case Series of Patients With Kidney Biopsies.
Kidney medicineA Review of Genetic Abnormalities in Unicentric and Multicentric Castleman Disease.
BiologyTreating life-threatening TAFRO syndrome with interleukin-1 inhibition.
European journal of internal medicineA Case of Repeated TAFRO Syndrome-Like Symptoms and Retroperitoneal Hemorrhage in a Patient With Sjögren Syndrome.
CureusThe Dangers of Immediately Performing a Sensitive and Specific Investigation versus the Dangers of Delaying It: A Cautionary Case of Hodgkin's Lymphoma.
European journal of case reports in internal medicine[Treatment of TAFRO syndrome with tocilizumab: a case report].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhiJAK1/2 Inhibition in Severe TAFRO Syndrome: A Case Report.
Annals of internal medicineA severe case of thrombocytopenia, anasarca, fever, renal insufficiency or reticulin fibrosis, and organomegaly syndrome with myocardial and skeletal muscle calcification despite hypocalcemia: a case report.
Journal of medical case reportsBorderline Case of TAFRO Syndrome and POEMS Syndrome.
Internal medicine (Tokyo, Japan)Sequential change in serum VEGF levels in a case of tocilizumab-resistant TAFRO syndrome treated effectively with rituximab.
Modern rheumatology case reportsKidney biopsy findings in two patients with TAFRO syndrome: case presentations and review of the literature.
BMC nephrology[TAFRO syndrome and cutaneous necrotizing vasculitis].
La Revue de medecine interneComplete Resolution of a Case of TAFRO Syndrome Accompanied by Mediastinal Panniculitis, Adrenal Lesion, and Liver Damage with Hyperbilirubinemia.
Internal medicine (Tokyo, Japan)[HHV-8-positive Castleman's disease with rapidly progressing multiorgan failure mimicking TAFRO syndrome].
[Rinsho ketsueki] The Japanese journal of clinical hematologyRecovery from prolonged thrombocytopenia in patients with TAFRO syndrome: case series and literature review.
Modern rheumatology case reportsDevelopment of severe thrombocytopenia with TAFRO syndrome-like features in a patient with rheumatoid arthritis treated with a Janus kinase inhibitor: A case report.
MedicineAn Autopsy Case of TAFRO Syndrome with Type II Respiratory Failure.
The American journal of case reportsPrimary Sjögren's Syndrome Accompanied by Clinical Features of TAFRO Syndrome.
Case reports in rheumatologyOptimal treatments for TAFRO syndrome: a retrospective surveillance study in Japan.
International journal of hematologyTocilizumab for the treatment of TAFRO syndrome: a systematic literature review.
Annals of hematologyThe Clinical and Histopathological Feature of Renal Manifestation of TAFRO Syndrome.
Kidney international reportsDisseminated Mycobacterium genavense infection mimicking TAFRO syndrome.
Journal of infection and chemotherapy : official journal of the Japan Society of ChemotherapyAscites in the "TAFRO" Syndrome: Does the Squeeze Make the Juice?
Digestive diseases and sciencesUnexplained cause of thrombocytopenia, fever, anasarca and hypothyroidism: TAFRO syndrome with thrombotic microangiopathy renal histology.
BMJ case reportsA pediatric case of tocilizumab-resistant TAFRO syndrome treated successfully with rituximab.
Pediatric blood & cancerFrontline Siltuximab and Rituximab in TAFRO syndrome: A case report.
European journal of haematologyAcute Kidney Injury Caused by TAFRO Syndrome in a Chinese Patient: Efficacy of Long-Term Corticosteroids Combined with Bortezomib and Cyclophosphamide.
Kidney & blood pressure researchComputed tomography findings of early-stage TAFRO syndrome and associated adrenal abnormalities.
European radiologyLiver cirrhosis in a child associated with Castleman's disease: A case report.
World journal of clinical casesThrombocytopenia, Anasarca, Fever, Reticulin Fibrosis/Renal Failure, and Organomegaly (TAFRO) Syndrome with Bilateral Adrenal Hemorrhage in Two Caucasian Patients.
The American journal of case reports[A report of six TAFRO syndrome: clinical characteristics, diagnosis and treatment analysis].
Zhonghua yi xue za zhiGenetic basis for iMCD-TAFRO.
OncogeneClinical features and treatment of 7 Chinese TAFRO syndromes from 96 de novo Castleman diseases: a 10-year retrospective study.
Journal of cancer research and clinical oncologyMulticentric Castleman disease with TAFRO syndrome and Sjögren's.
Clinical case reports[TAFRO syndrome, variant of Castleman's disease: case report].
Revista medica del Instituto Mexicano del Seguro SocialTAFRO Syndrome Presenting with Retroperitoneal Panniculitis-like Computed Tomography Findings at Disease Onset.
Internal medicine (Tokyo, Japan)2019 Updated diagnostic criteria and disease severity classification for TAFRO syndrome.
International journal of hematologyEpidemiological analysis of multicentric and unicentric Castleman disease and TAFRO syndrome in Japan.
Journal of clinical and experimental hematopathology : JCEHHepatic Campylobacter jejuni infection in patients with Castleman-Kojima disease (idiopathic multicentric Castleman disease with thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome).
Pathology internationalTAFRO syndrome as a cause of glomerular microangiopathy: a case report and literature review.
BMC nephrologyFatal case of TAFRO syndrome associated with over-immunosuppression: a case report and review of the literature.
Nagoya journal of medical scienceTAFRO Syndrome: A Case of Significant Endocrinopathy in a Caucasian Patient.
CureusThe potential role of follicular helper T cells in idiopathic multicentric Castleman disease with and without TAFRO syndrome.
Pathology, research and practiceRenal Pathologic Findings in TAFRO Syndrome: Is There a Continuum Between Thrombotic Microangiopathy and Membranoproliferative Glomerulonephritis? A Case Report and Literature Review.
Frontiers in immunologyIs TAFRO syndrome a subtype of idiopathic multicentric Castleman disease?
American journal of hematologyComparison of the clinical characteristics of TAFRO syndrome and idiopathic multicentric Castleman disease in general internal medicine: a 6-year retrospective study.
Internal medicine journalSubclinical Hypothyroidism in TAFRO Syndrome.
Internal medicine (Tokyo, Japan)Pathological findings of progressive renal involvement in a patient with TAFRO syndrome.
CEN case reportsA case of cerebral infarction in a patient with TAFRO syndrome.
Journal of the neurological sciencesTAFRO Syndrome with an Anterior Mediastinal Mass and Lethal Autoantibody-Mediated Thrombocytopenia: An Autopsy Case Report.
Acta haematologicaTAFRO Syndrome: A Case Report from Turkey and Review of the Literature.
International journal of hematology-oncology and stem cell researchClinicopathological features of TAFRO syndrome complicated by acquired hemophilia A and development of cardiopulmonary arrest that were successfully treated with VA-ECMO and tocilizumab.
International journal of hematologyAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Recovery trajectories of TAFRO syndrome: a single-center case series highlighting prolonged thrombocytopenia and anasarca.
- The value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the diagnosis and evaluation of TAFRO syndrome: a review of cases and literature.
- Concurrent Idiopathic Multicentric Castleman Disease with TAFRO and Sjögren's Syndrome in a Young Patient: A Challenging Diagnostic Overlap.
- Correction: TAFRO syndrome requiring combined IL 6 and IL 1 inhibition: a case report.
- Ruxolitinib in relapsed/refractory TAFRO syndrome: a report of two cases, including one positive for Epstein-Barr virus, and a literature review.
- Successful Treatment of Refractory Pediatric TAFRO Syndrome With Combination Chemotherapy: A Case Report.
- Ultrasound-guided lateral kidney biopsy in patients unsuitable for the prone position.
- Morphological characteristics of the renal lesion in TAFRO syndrome and POEMS syndrome: a retrospective and multicenter study.
- [The 516th case: hyperinflammatory state, acute renal dysfunction, hepatosplenomegaly with lymphadenopathy, and recurrent cerebral infarctions].
- Primary adrenal insufficiency and autoimmune thyroiditis in an adolescent with Castleman-TAFRO syndrome.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:457077(Orphanet)
- MONDO:0018702(MONDO)
- GARD:21902(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Q55788267(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
