A síndrome de Moebius é um distúrbio congênito de desinervação craniana muito raro, caracterizado por paralisia facial completa ou incompleta em associação com paralisia bilateral do nervo abducente, causando comprometimento da abdução ocular. A síndrome também inclui várias outras anomalias congênitas.
Introdução
O que você precisa saber de cara
A síndrome de Moebius é um distúrbio congênito de desinervação craniana muito raro, caracterizado por paralisia facial completa ou incompleta em associação com paralisia bilateral do nervo abducente, causando comprometimento da abdução ocular. A síndrome também inclui várias outras anomalias congênitas.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 41 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 93 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
2 genes identificados com associação a esta condição. Padrão de herança: Autosomal dominant.
Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in respons
Cell membraneCell projection, lamellipodium membrane
Congenital heart defects, multiple types, 9
An autosomal recessive disorder characterized by congenital developmental abnormalities involving structures of the heart. CHTD9 features include common arterial trunk, tetralogy of Fallot, interrupted aortic arch, right aortic arch, ventricular hypoplasia, and hypoplastic left heart, as well as other vascular and valvular anomalies.
Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function
Nucleus
Variantes genéticas (ClinVar)
47 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
6 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Síndrome Moebius
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Pesquisa e ensaios clínicos
Nenhum ensaio clínico registrado para esta condição.
Publicações mais relevantes
Update on Congenital Cranial Dysinnervation Disorders (CCDDs).
Congenital cranial dysinnervation disorders (CCDDs) are a group of rare, nonprogressive conditions characterized by abnormal development of the cranial motor nerves and variable ocular motility deficits, ptosis, incomitant strabismus, and facial palsy. Advances in genetics and neuroimaging have revealed that these disorders result from defects in neuronal differentiation or axon guidance of the cranial motor neurons. Duane retraction syndrome, the most common CCDD, results from the absence of the abducens nerve and innervation of the lateral rectus by oculomotor nerve axons; causative genes include CHN1, MAFB, HOXA1, SALL4, and EBF3, although most cases do not have a genetic diagnosis. Congenital fibrosis of the extraocular muscles (CFEOM), results from variants in KIF21A, PHOX2A, TUBB3, or other tubulin genes, and affects the oculomotor and trochlear nerves. Horizontal gaze palsy with progressive scoliosis (HGPPS), caused by ROBO3 loss of function, arises from failure of axonal midline crossing in the brainstem. Moebius syndrome, defined by abducens and facial nerve palsies, has no identified genetic cause and may result from non-Mendelian causes. Additional CCDDs with atypical or syndromic presentations are linked to COL25A1, ECEL1, and ACKR3, although many do not have a genetic explanation. The expanding list of CCDD-associated genes highlights shared developmental pathways, including neuronal differentiation, axon guidance, and microtubule dynamics. Improved genetic diagnosis informs prognosis and multidisciplinary management. This review synthesizes current understanding of CCDDs, emphasizing the shift from phenotypic classification to molecular subtyping, and underscores the importance of ongoing research to resolve genetically unsolved cases and refine diagnostic and therapeutic strategies.
Rapid Eye Movement (REM) Sleep Behaviour Disorder in Moebius Syndrome: A Rare Pediatric Case.
Moebius syndrome is a rare, non-progressive congenital disorder, most commonly characterized by impairment of the abducens (VI) and facial (VII) cranial nerves, resulting in facial palsy and limited ocular abduction. A broad spectrum of associated clinical manifestations includes craniofacial abnormalities, limb malformations, and neuromotor developmental delay. Sleep disorders are frequently reported in these patients, most often related to sleep-disordered breathing. In contrast, rapid eye movement (REM) sleep behavior disorder (RBD) is exceptionally rare, both in pediatric patients and in association with this syndrome. We report the case of a 13-year-old male diagnosed with Moebius syndrome in the neonatal period, who developed recurrent episodes of nocturnal agitation, vocalizations, and dream enactment behaviors. Polysomnography demonstrated structural alterations of REM sleep with reduced muscle atonia and abnormal motor activity, findings consistent with RBD. Despite the implementation of sleep hygiene measures and pharmacological therapy, clinical response was limited. This case underscores the importance of actively investigating sleep disturbances in Moebius syndrome, not only to address the more common sleep-related breathing disorders but also to recognize rare conditions, such as RBD, which may significantly impact quality of life. Given the scarcity of evidence on pediatric RBD, particularly in association with congenital neurological syndromes, further research is needed to improve diagnostic and therapeutic strategies.
[Moebius syndrome after maternal misoprostol use].
This case report describes a newborn with clinical and radiological features compatible with Moebius syndrome following first-trimester maternal use of misoprostol intended for medical abortion. Despite early vaginal bleeding, the pregnancy continued and the parents opted to proceed. Prenatal ultrasound showed bilateral clubfeet, and postnatal examination revealed cranial nerve dysfunction, hypotonia, and feeding difficulties. An MRI of the cerebrum demonstrated hypoplasia of the pons, thalamic fusion, and absence of the nervus abducens and nervus facialis, findings that support a diagnosis of Moebius syndrome. The report highlights the association between early gestational misoprostol exposure and congenital anomalies, which may not be detectable via prenatal imaging. Counseling and multidisciplinary follow-up are essential. Although the absolute risk is low, clinicians should remain aware of the teratogenic risks after misoprostol exposure.
Craniofacial surgery needs in the Moebius syndrome population.
Sagittal craniosynostosis with Moebius syndrome; case illustration: first case in the literatüre.
Our aim in this article is to contribute to the clinical findings of Moebius syndrome with the association of synostosis published for the first time. In 2023, the Pediatric Neurosurgery Department operated sagittal synostosis case with Moebius syndrome was retrieved from the neurosurgery archive with literatüre review. A 6-month-old girl who could not close her eyes and mouth after birth was followed up in another hospital with the diagnosis of Moebius Syndrome and was referred to us because of cranial deformity. Moebius syndrome is a syndrome whose cause and clinical framework still need to be fully clarified and is being updated with studies. For this reason, it is essential to recognize the clinical findings seen in patients well, to direct them to genetic research if necessary, and to pay attention to new manifestations that may be added in this context in terms of scientific transfer.
Publicações recentes
Anatomical Variation of Absent Facial Vein: Implications for Facial Reanimation Surgery.
Update on Congenital Cranial Dysinnervation Disorders (CCDDs).
Rapid Eye Movement (REM) Sleep Behaviour Disorder in Moebius Syndrome: A Rare Pediatric Case.
[Moebius syndrome after maternal misoprostol use].
A Rare Triad of Congenital Facial, Abducens, and Hypoglossal Nerve Palsies: A Case Report.
📚 EuropePMC272 artigos no totalmostrando 146
Update on Congenital Cranial Dysinnervation Disorders (CCDDs).
International ophthalmology clinicsRapid Eye Movement (REM) Sleep Behaviour Disorder in Moebius Syndrome: A Rare Pediatric Case.
Cureus[Moebius syndrome after maternal misoprostol use].
Nederlands tijdschrift voor geneeskundeA Rare Triad of Congenital Facial, Abducens, and Hypoglossal Nerve Palsies: A Case Report.
CureusKissing Cochlea: An Extreme Inner Ear Malformation, Novel Surgical Approach via Cystic Vestibule.
The LaryngoscopeAnesthetic Challenges of Caring for an Adult With Moebius Syndrome: A Case Report.
Case reports in anesthesiologyCraniofacial surgery needs in the Moebius syndrome population.
Journal of plastic, reconstructive & aesthetic surgery : JPRASSagittal craniosynostosis with Moebius syndrome; case illustration: first case in the literatüre.
BMC pediatricsModified Nishida's procedure combined with medial rectus recession in a case of Moebius syndrome.
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and StrabismusBronchial stenosis in an 8-year-old with Moebius syndrome: A case report.
International journal of surgery case reportsQuality of Life in Children and Adolescents With Facial Palsy: A Scoping Review.
The Journal of craniofacial surgeryEvaluating Dynamic Smile Outcomes of Free Gracilis Muscle Transfer in Pediatric Facial Palsy Using Image-Based Analysis.
Journal of reconstructive microsurgerySystematic phenotype and genotype characterization of Moebius syndrome.
Genetics in medicine openMultimodality Craniofacial Phenotyping of Congenital Facial Weakness Disorders.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationTransformative Dental Care in Pediatric Moebius Syndrome: Bridging Oral Health and Systemic Management During Prolonged Hospitalization.
Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric DentistryFacial reanimation in Moebius syndrome - 25-Year experience in treating bilateral facial paralysis.
Journal of plastic, reconstructive & aesthetic surgery : JPRASThe Etiology of Moebius Syndrome-Making the Case for Animal Models.
International journal of molecular sciencesMoebius-plus: a severe congenital multiple cranial neuropathy syndrome.
BMJ case reportsMoebius Syndrome associated with syringomyelia: a case report.
Einstein (Sao Paulo, Brazil)Facial Reanimation in Moebius Syndrome Using Bilateral Free Gracilis Transfer: 1-Stage versus 2-Stage Procedures.
Plastic and reconstructive surgerySleep health of adults and children with Moebius syndrome.
Research in developmental disabilitiesMoebius syndrome and hypopituitarism: a case of multiple pituitary hormone deficiency and revision of the literature.
Journal of pediatric endocrinology & metabolism : JPEMOrthodromic Reshaping Temporalis Tendon Transfer for Aesthetic Facial Reanimation in Adults with Moebius Syndrome and Bilateral Facial Paralysis: Technical Insights and Indications.
Facial plastic surgery & aesthetic medicineHypersomnia and cataplexy in Moebius syndrome.
Sleep medicineThrough their eyes: Navigating life with limited eyelid closure in patients with Moebius syndrome.
Journal of plastic, reconstructive & aesthetic surgery : JPRASJob discrimination against applicants with the Moebius syndrome.
Acta psychologicaExploring the Impact of Genetics in a Large Cohort of Moebius Patients by Trio Whole Exome Sequencing.
GenesPostoperative multimodal rehabilitation for spontaneous smile restoration in severe Moebius syndrome: A case report and a short literature review.
SAGE open medical case reportsBeyond the Eyes: Clinico-Radiological Correlation of Bilateral Complete Horizontal Gaze Palsy in Moebius Syndrome.
CureusMultidisciplinary Care for Moebius Syndrome and Related Disorders: Building a Management Protocol.
Journal of clinical medicinePrevalence of congenital anomalies and prenatal diagnosis by birth institution (public vs. non-public): indicators of inequality in access to elective termination of pregnancy for fetal anomalies.
Journal of community geneticsOral Health-Related Quality of Life in Rare Disorders of Congenital Facial Weakness.
International journal of environmental research and public healthCommentary on: "A New Technique in Facial Reanimation Surgery for Moebius Syndrome" by Simmons et al.
Facial plastic surgery & aesthetic medicineA New Technique in Facial Reanimation Surgery for Moebius Syndrome.
Facial plastic surgery & aesthetic medicineOn the Role of Sensorimotor Experience in Facial Expression Perception.
Journal of cognitive neuroscienceTreatment Approaches for Altered Facial Expression: A Systematic Review in Facioscapulohumeral Muscular Dystrophy and Other Neurological Diseases.
Journal of neuromuscular diseasesCase report: Identification of a novel variant p.Gly215Arg in the CHN1 gene causing Moebius syndrome.
Frontiers in geneticsOral findings and comprehensive dental management of Moebius syndrome: a systematic review.
BMC oral healthPhysiopathologic Bases of Moebius Syndrome: Combining Genetic, Vascular, and Teratogenic Theories.
Pediatric neurologyExpanding the Phenotype of Hereditary Congenital Facial Paresis Type 3.
International journal of molecular sciencesMoebius Syndrome: An Updated Review of Literature.
Child neurology openInability to move one's face dampens facial expression perception.
Cortex; a journal devoted to the study of the nervous system and behaviorImpact of Social Determinants of Health in the Care of Moebius Syndrome: A Case Report.
CureusPsychosocial functioning in patients with altered facial expression: a scoping review in five neurological diseases.
Disability and rehabilitationMoebius syndrome and gastroschisis-The second case of a rare association.
American journal of medical genetics. Part ASensitivity to basic emotional expressions and the emotion perception space in the absence of facial mimicry: The case of individuals with congenital facial palsy.
Emotion (Washington, D.C.)Monozygotic twins discordant for a congenital cranial dysinnervation disorder with features of Moebius syndrome.
American journal of medical genetics. Part ADiagnosis and Dental Management of a Child with Moebius Syndrome: A Case Report.
International journal of clinical pediatric dentistryMoebius Syndrome: A Case Report on an Uncommon Congenital Syndrome.
CureusThe challenging management of Moebius syndrome using orthodontic camouflage: A case report.
Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric DentistryUnusual case of Trigeminal Neuralgia Associated with Poland -Moebius Syndrome.
Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of IndiaTesting EEG functional connectivity between sensorimotor and face processing visual regions in individuals with congenital facial palsy.
Frontiers in systems neuroscienceMoebius Syndrome: What We Know So Far.
CureusCongenital facial nerve palsy: Single center study.
Frontiers in pediatricsIrregular sleep-wake rhythm disorder Masquerading as hypersomnia in Moebius syndrome.
Sleep medicinePoland-Möbius syndrome: a case report implicating a novel mutation of the PLXND1 gene and literature review.
BMC pediatricsSimultaneous Bilateral Proximal Femur Implant Failure: A Case Report.
CureusMoebius syndrome-Case report.
Clinical case reportsA Missense Mutation in LMX1A in a Patient With Moebius Syndrome: A Case Report.
CureusAcute Respiratory Distress in a Pediatric Patient With Prader-Willi and Moebius Syndromes.
CureusDifficult intubation and postoperative aspiration pneumonia associated with Moebius syndrome: a case report.
BMC anesthesiologyAssociated anomalies in cases with achondroplasia.
European journal of medical geneticsDegenerate pathway for processing smile and other emotional expressions in congenital facial palsy: an hdEEG investigation.
Philosophical transactions of the Royal Society of London. Series B, Biological sciencesOrthodontic treatment in a patient with Moebius syndrome: A case report.
Korean journal of orthodonticsZygomatic Muscle Neurotization with Nerve Grafts and End-to-Side Neurorrhaphies: A New Technique for Facial Palsy.
Plastic and reconstructive surgery. Global openPost-surgery Rehabilitative Intervention Based on Imitation Therapy and Mouth-Hand Motor Synergies Provides Better Outcomes in Smile Production in Children and Adults With Long Term Facial Paralysis.
Frontiers in neurologyFacial Expression Time Processing in Typical Development and in Patients with Congenital Facial Palsy.
Brain sciencesExtracellular vesicles-derived microRNAs expression as biomarkers for neurological radiation injury: Risk assessment for space exploration.
Life sciences in space researchFacial paralysis, etiology and surgical treatment in a tertiary care center in plastic and reconstructive surgery in Mexico.
Cirugia y cirujanosImpact of Adding Augmented Superior Rectus Transpositions to Medial Rectus Muscle Recessions When Treating Esotropic Moebius Syndrome.
American journal of ophthalmologySplenogonadal fusion associated with Moebius and Poland syndromes: first case reported.
Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia PediatricaDental management of a patient with Moebius syndrome: A case report.
World journal of clinical casesNeurogenic bladder as a lurking complication in Moebius syndrome.
Brain & developmentSurgical Treatment of Clubfoot in Children with Moebius Syndrome.
Children (Basel, Switzerland)A New Neurorehabilitative Postsurgery Intervention for Facial Palsy Based on Smile Observation and Hand-Mouth Motor Synergies.
Neural plasticityThe epidemiology of Moebius syndrome in Italy.
Orphanet journal of rare diseasesPrevalence of Hand Malformations in Patients With Moebius Syndrome and Their Management.
Hand (New York, N.Y.)Workhorse Free Functional Muscle Transfer Techniques for Smile Reanimation in Children with Congenital Facial Palsy: Case Report and Systematic Review of the Literature.
Journal of plastic, reconstructive & aesthetic surgery : JPRASCephalometric Analysis of the Craniofacial Morphology in Patients With Moebius Syndrome.
The Journal of craniofacial surgeryManagement of a case of anticipated difficult airway in a patient with Moebius syndrome.
Indian journal of anaesthesiaDevelopmental delay with hypotrophy associated with homozygous functionally relevant REV3L variant.
Journal of molecular medicine (Berlin, Germany)Differentiating Moebius syndrome and other congenital facial weakness disorders with electrodiagnostic studies.
Muscle & nerveLong-term results of facial animation surgery in patients with Moebius syndrome.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial SurgeryMoebius Syndrome: A Rare Entity or a Missed Diagnosis?
Journal of pediatric neurosciencesAdjustable graded augmentation of superior rectus transposition for treatment of abducens nerve palsy and Duane syndrome.
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and StrabismusOromandibular Limb Hypogenesis Syndrome: Overlap of Moebius and Ankyloglossia Superior With Severe Limb Defects.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationMoebius syndrome: Craniofacial clinical manifestations and their association with prenatal exposure to misoprostol.
Laryngoscope investigative otolaryngologyDiagnosis and treatment of speech disorders in children with Moebius syndrome.
International journal of pediatric otorhinolaryngologyA Systematic Review of the Psychosocial Adjustment of Children and Adolescents with Facial Palsy: The Impact of Moebius Syndrome.
International journal of environmental research and public healthSleep-related breathing disorders associated with the characteristics of underlying congenital rare diseases of Moebius syndrome and Poland syndrome.
Respirology case reportsBrain phenotyping in Moebius syndrome and other congenital facial weakness disorders by diffusion MRI morphometry.
Brain communicationsElectromyographic evaluation of the facial and motor donor nerves before facial reanimation surgery in Moebius syndrome.
Cirugia y cirujanosOrofacial motor dysfunction in Moebius syndrome.
Developmental medicine and child neurologyAnkyloglossia Superior Associated With Moebius Syndrome: A Case Report.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial SurgeonsChildren with facial paralysis due to Moebius syndrome exhibit reduced autonomic modulation during emotion processing.
Journal of neurodevelopmental disordersDifficult Airway Identification and Management in Patients With Moebius Syndrome.
The Journal of craniofacial surgeryMoebius syndrome: The challenge of dental management.
European journal of paediatric dentistryCongenital unilateral facial palsy revealing a facial nerve agenesis: a case report and review of the literature.
BJR case reportsAutonomic Responses to Emotional Stimuli in Children Affected by Facial Palsy: The Case of Moebius Syndrome.
Neural plasticityMultigenic truncation of the semaphorin-plexin pathway by a germline chromothriptic rearrangement associated with Moebius syndrome.
Human mutationNeuroimaging Findings in Moebius Sequence.
AJNR. American journal of neuroradiologyCongenital facial palsy and emotion processing: The case of Moebius syndrome.
Genes, brain, and behavior[Airway management in the neonate with Moebius syndrome].
Anales de pediatriaWill the real Moebius syndrome please stand up? A systematic review of the literature and statistical cluster analysis of clinical features.
American journal of medical genetics. Part APsychological adjustment of young subjects with Möbius sequence and their primary caregivers' strain and life satisfaction: First longitudinal data.
Research in developmental disabilitiesEvaluation of Moebius syndrome with hand manifestations.
Acta orthopaedica BelgicaOphthalmoplegia and Congenital Cranial Dysinnervation Disorders.
Journal of binocular vision and ocular motilityMagnetic resonance imaging of developmental facial paresis: a spectrum of complex anomalies.
NeuroradiologyMoebius Syndrome with Hypoglossal Palsy, Syndactyly, Brachydactyly, and Anisometropic Amblyopia.
CureusBrainstem dysgenesis: beyond Moebius syndrome.
Revista de neurologiaOrthodontics and Moebius syndrome: an observational study.
Minerva stomatologicaPathogenesis of cranial neuropathies in Moebius syndrome: Electrodiagnostic orofacial studies.
Muscle & nerveAn interesting case of systemic lupus erythematosus in a patient with Moebius syndrome.
Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric DentistryTUBB3 E410K syndrome with osteoporosis and cough syncope in a patient previously diagnosed with atypical Moebius syndrome.
Brain & developmentMorphological changes in support mechanism of superficial face layers in Moebius syndrome.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie[Evidence level and grade of recommendation of the Ponseti method for arthrogryposis-related syndromic talipes equinovarus and Moebius syndrome: a systematic review].
Acta ortopedica mexicanaProsthodontic Management of a Patient with Moebius Syndrome: A Clinical Report.
Journal of prosthodontics : official journal of the American College of ProsthodontistsAdvances in paediatrics in 2016: current practices and challenges in allergy, autoimmune diseases, cardiology, endocrinology, gastroenterology, infectious diseases, neonatology, nephrology, neurology, nutrition, pulmonology.
Italian journal of pediatricsA Novel Loss-of-Function Mutation in HOXB1 Associated with Autosomal Recessive Hereditary Congenital Facial Palsy in a Large Iranian Family.
Molecular syndromologyIdentification of STAC3 variants in non-Native American families with overlapping features of Carey-Fineman-Ziter syndrome and Moebius syndrome.
American journal of medical genetics. Part AA defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome.
Nature communicationsAugmented superior rectus transposition surgery for vertical strabismus in moebius syndrome.
Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPHA proposal for new neurorehabilitative intervention on Moebius Syndrome patients after 'smile surgery'. Proof of concept based on mirror neuron system properties and hand-mouth synergistic activity.
Neuroscience and biobehavioral reviewsPre- and Postsurgical Orthodontics in Patients with Moebius Syndrome.
Case reports in dentistry"Rare place where I feel normal": Perceptions of a social support conference among parents of and people with Moebius syndrome.
Research in developmental disabilitiesAn exome sequencing study of Moebius syndrome including atypical cases reveals an individual with CFEOM3A and a TUBB3 mutation.
Cold Spring Harbor molecular case studiesThree Cases of Exotropic Moebius Syndrome.
Journal of pediatric ophthalmology and strabismusEnhancing surgical outcomes: The effects of speech therapy on a school-aged girl with Moebius Syndrome.
International journal of pediatric otorhinolaryngologyMOEBIUS SYNDROME: CHALLENGES OF AIRWAY MANAGEMENT.
Acta clinica CroaticaMoebius syndrome: clinical features, diagnosis, management and early intervention.
Italian journal of pediatricsOphthalmic profile and systemic features of pediatric facial nerve palsy.
Eye science[Electromyographic assessment of the temporalis muscle prior to a lengthening myoplasty in patients with Moebius syndrome].
Annales de chirurgie plastique et esthetiqueSalivary parameters and oral health in the Moebius syndrome.
Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric DentistryPostobstructive Pulmonary Edema following Tonsillectomy/Adenoidectomy in a 2-Year-Old with Poland-Moebius Syndrome.
Case reports in otolaryngologyQuality of life and adjustment in children and adolescents with Moebius syndrome: Evidence for specific impairments in social functioning.
Research in developmental disabilitiesCaries Experience in Individuals with Moebius Syndrome.
Pediatric dentistryManaging the child with a diagnosis of Moebius syndrome: more than meets the eye.
Archives of disease in childhoodConsiderations on the etiology of congenital Brown syndrome.
Current opinion in ophthalmologyDe novo mutations in PLXND1 and REV3L cause Möbius syndrome.
Nature communicationsA new hereditary congenital facial palsy case supports arg5 in HOX-DNA binding domain as possible hot spot for mutations.
European journal of medical geneticsAtraumatic restorative technique: case report on dental management of a patient with Moebius syndrome.
Australian dental journalCongenital cranial dysinnervation disorder in a boy with congenital mirror movements.
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus[Congenital cranial dysinnervation disorders (CCDD)].
Klinische Monatsblatter fur AugenheilkundeUnmasking Moebius syndrome.
NursingExamining the genetics of congenital facial paralysis--a closer look at Moebius syndrome.
Oral and maxillofacial surgeryTreatment of migration and extrusion of the gold weight eyelid implant with fascia lata sandwich graft technique.
The Journal of craniofacial surgeryAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Síndrome Moebius.
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Comunidades
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Update on Congenital Cranial Dysinnervation Disorders (CCDDs).
- Rapid Eye Movement (REM) Sleep Behaviour Disorder in Moebius Syndrome: A Rare Pediatric Case.
- [Moebius syndrome after maternal misoprostol use].
- Craniofacial surgery needs in the Moebius syndrome population.
- Sagittal craniosynostosis with Moebius syndrome; case illustration: first case in the literatüre.
- Anatomical Variation of Absent Facial Vein: Implications for Facial Reanimation Surgery.
- A Rare Triad of Congenital Facial, Abducens, and Hypoglossal Nerve Palsies: A Case Report.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:570(Orphanet)
- OMIM OMIM:157900(OMIM)
- MONDO:0008006(MONDO)
- GARD:8549(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q1418152(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
