A miastenia gravis (MG) é uma doença autoimune rara, clinicamente heterogênea e da junção neuromuscular, caracterizada por fraqueza cansativa dos músculos voluntários.
Introdução
O que você precisa saber de cara
A miastenia gravis (MG) é uma doença autoimune rara, clinicamente heterogênea e da junção neuromuscular, caracterizada por fraqueza cansativa dos músculos voluntários.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 33 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 62 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
3 genes identificados com associação a esta condição. Padrão de herança: Multigenic/multifactorial, Not applicable.
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC
Cell membraneEndoplasmic reticulum membraneGolgi apparatus, trans-Golgi network membraneEndosome membraneLysosome membrane
Inhibitory receptor acting as a major negative regulator of T-cell responses (PubMed:11279501, PubMed:11279502, PubMed:16551244, PubMed:1714933, PubMed:18641304, PubMed:28484017). Acts as a decoy receptor: the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 (PubMed:11279501, PubMed:11279502, PubMed:16551244, PubMed:1714933, PubMed:28484017)
Cell membrane
Systemic lupus erythematosus
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis (PubMed:9878548). Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2 (By similarity). Involved in the regulation of interactions between T-cells and dendritic cells (By similarity)
Cell membraneMembrane raft
Familial expansile osteolysis
Rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. The osteolytic lesions develop usually in the long bones during early adulthood. FEO is often associated with early-onset deafness and loss of dentition.
Medicamentos aprovados (FDA)
2 medicamentos encontrados nos registros da FDA americana.
Variantes genéticas (ClinVar)
263 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
12 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Miastenia gravis
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
🟢 Recrutando agora
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Outros ensaios clínicos
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 7.291
Half a century of change: demographic trends and their clinical impact in acetylcholine receptor antibody-positive myasthenia gravis.
Este estudo de 50 anos revela uma mudança demográfica na Miastenia Gravis (MG), com a idade média de início aumentando significativamente para pacientes mais velhos. Para pacientes e médicos, é crucial saber que pacientes com início precoce tendem a ter melhores taxas de remissão completa ou mínima, enquanto aqueles com início muito tardio frequentemente enfrentam um manejo mais desafiador e maior risco de eventos adversos relacionados ao tratamento.
🇧🇷 traduzidoNeuro-immune interactions underlying autoimmune diseases: insights from brain imaging data.
Este estudo inovador aponta que o cérebro (Sistema Nervoso Central) tem um papel causal no desenvolvimento de doenças autoimunes, como a Miastenia Gravis, influenciando-as através de interações com o sistema imunitário. Para pacientes e médicos, esta descoberta abre caminho para o desenvolvimento de novas e promissoras estratégias de diagnóstico e tratamento, que visam modular as complexas conexões entre o cérebro e a imunidade.
🇧🇷 traduzidoMorvan syndrome in a patient with progressing metastatic thymoma and myasthenia gravis.
A Síndrome de Morvan (SM) é uma condição paraneoplásica rara que pode surgir em pacientes com doenças autoimunes como a Miastenia Gravis (MG), especialmente em casos de timoma. O artigo descreve um caso em que o reconhecimento e o diagnóstico precoce da SM foram cruciais para a administração de imunoterapia oportuna. Isso levou a uma melhora clínica rápida e significativa, sublinhando a importância vital da vigilância para médicos e pacientes diante de sintomas neurológicos complexos.
🇧🇷 traduzidoRisk of New-Onset Myasthenia Gravis Following COVID-19 Infection and Vaccination: A Population-Based Case-Control Study.
Este estudo sugere que a infecção por COVID-19 não está significativamente associada a um risco aumentado de miastenia gravis (MG) de novo início. No entanto, a vacina Pfizer-BioNTech parece estar associada a um risco maior de desenvolver MG, especialmente dentro de 180 dias após a vacinação. Este é um ponto importante para pacientes e médicos considerarem ao avaliar riscos e benefícios da vacinação e no monitoramento de novos sintomas.
🇧🇷 traduzidoMinimal Symptom Expression in Generalized Myasthenia Gravis: A Valuable Patient-Centric Treatment Goal.
Para pacientes e médicos com miastenia gravis generalizada (gMG), a **"Expressão Mínima de Sintomas" (MSE)** surge como um objetivo de tratamento valioso e focado no paciente. A MSE, que significa ter sintomas quase inexistentes nas atividades diárias, é alcançável com terapias biológicas modernas, correlaciona-se com melhorias significativas na qualidade de vida e avaliações médicas. Ela serve como uma meta prática e integrada para o manejo da doença, priorizando o bem-estar do paciente.
🇧🇷 traduzidoPublicações recentes
Massive Bilateral Pulmonary Embolism Presenting as Isolated Abdominal Pain: An Atypical Presentation and Incidental Detection in Dual Immune-Mediated Disease.
Exploring medication adherence and illness perception in patients with neuroimmune diseases: a cross-sectional study.
Case report: Efgartigimod combined with intravenous methylprednisolone in a case of co-occurrence of unexplained myasthenia gravis, inflammatory myopathy, and fulminant myocarditis.
🥈 ObservacionalAdaptive Therapeutic Plasma Exchange Technologies in Low-resource Settings: Utilization, Safety, and Clinical Insights from 2507 Neurological Cases.
🥈 CoorteDifferential Toxicity of Immune Checkpoint Inhibitors in Older Adults: A Large-Scale, Propensity Score-Matched Real-World Analysis.
📖 Revisão📚 EuropePMC13.933 artigos no totalmostrando 194
Should Patients With Ocular Myasthenia Gravis Be Started on Immunosuppression to Prevent Generalization?
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology SocietyHalf a century of change: demographic trends and their clinical impact in acetylcholine receptor antibody-positive myasthenia gravis.
Journal of neurologyOn the increased prevalence of myasthenia gravis in patients with inflammatory bowel disease.
Arquivos de neuro-psiquiatriaBeyond numbers: challenges in assessing myasthenia gravis prevalence in inflammatory bowel disease.
Arquivos de neuro-psiquiatriaPediatric Myasthenia Gravis.
International ophthalmology clinicsCase Report: Vitiligo and Alopecia Universalis Following Rituximab Therapy in a Patient with Myasthenia Gravis.
Clinical, cosmetic and investigational dermatologyCase Report: Dual response to efgartigimod in myasthenia gravis and comorbid autoimmune disorders: a case series.
Frontiers in immunologyFrom Limited Samples to Mechanistic Insights: Exploratory Identification and Functional Validation of a hsa_circ_0062400/hsa_circ_0002397-miR-338-3p-NRP1 Axis in Myasthenia Gravis.
Endocrine, metabolic & immune disorders drug targetsBridging the gap between patient and physician perspectives on management of generalized myasthenia gravis: a Delphi consensus study.
Orphanet journal of rare diseasesThe Effect of Thymectomy on the Incidence of Extrathymic Cancers and Autoimmune Diseases in Patients With Non-Thymomatous Myasthenia Gravis.
Muscle & nerveBurden of glucocorticoid use in commercially insured adults with generalized myasthenia gravis in the United States: A retrospective claims-based analysis.
MedicineHsa_circ_0000313/miR-1224-3p/MKNK2 Axis Modulates CD4+ T Cells by Activating p38 MAPK Signaling in Myasthenia Gravis.
Mediators of inflammationVery Late-Onset Generalized Myasthenia Gravis Presenting With Worsening Frailty.
CureusNeuro-immune interactions underlying autoimmune diseases: insights from brain imaging data.
Molecular brainItalian recommendations for the diagnosis and treatment of myasthenia gravis.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyMorvan syndrome in a patient with progressing metastatic thymoma and myasthenia gravis.
BMJ case reportsRisk of New-Onset Myasthenia Gravis Following COVID-19 Infection and Vaccination: A Population-Based Case-Control Study.
European journal of neurologyMinimal Symptom Expression in Generalized Myasthenia Gravis: A Valuable Patient-Centric Treatment Goal.
European journal of neurologyEffectiveness and Safety of Eculizumab in Highly Active AChR+gMG and Its Therapeutic Response in Different Subtypes of gMG.
ImmunoTargets and therapyLetter regarding impact of corticosteroid use on comorbidities in patients with myasthenia gravis in the US National Veterans Affairs Health Network.
Journal of the neurological sciencesThymic epithelial tumors at the crossroads of immunity, autoimmunity, and immunotherapy.
Cancer immunology, immunotherapy : CIISexual health in neuromuscular diseases: Neglected challenges revealed by a scoping review.
Journal of neuromuscular diseasesNeurological immune-related adverse events of immune-checkpoint inhibitors: an updated review.
Presse medicale (Paris, France : 1983)SEC-based isolation of phosphatidylserine-liposomes from biological samples for preclinical studies.
Analytical and bioanalytical chemistryDouble-Filtration Plasmapheresis Versus Efgartigimod for Generalized Myasthenia Gravis: Severity-Stratified Benefits in a Prospective Observational Multicenter Study.
CNS neuroscience & therapeuticsA high-throughput screening platform for acetylcholinesterase inhibitors using a genetically encoded acetylcholine fluorescent sensor.
Frontiers in bioengineering and biotechnologyThe Fiscal Consequences for the Canadian Government of Efgartigimod in the Treatment of Generalized Myasthenia Gravis.
Journal of health economics and outcomes researchComorbidities and Treatment Patterns in People With Myasthenia Gravis in Denmark, Finland and Sweden: A Population-Based Observational Study.
Muscle & nerveClinical and quality-of-life outcomes associated with efgartigimod in patients with generalized myasthenia gravis transitioning from intravenous immunoglobulin.
Clinical neurology and neurosurgeryCo-occurrence of systemic lupus erythematosus and myasthenia gravis: Insights from a cross-sectional cohort.
Clinical neurology and neurosurgeryWhen Central Tolerance Fails: Thymic Malignancies at the Intersection of Cancer Immunity and Autoimmunity.
CancersShared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits.
Nature communicationsAssociation between obesity and subsequent risk of myasthenia gravis: a nationwide population-based cohort study.
Acta neurologica BelgicaEstimating the minimal clinically important difference for the Myasthenia Gravis Quality of Life revised scale (MG-QOL15R).
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitationWho Can Safely Discontinue Treatment in Myasthenia Gravis? Insights From a Long-Term Real-World Study.
European journal of neurologyA Decade of Surgical Management of Thymic Tumours in Western Australia.
ANZ journal of surgeryOld Foundations in a New Era of Myasthenia Gravis Therapy.
Muscle & nerveAnalysis of adverse drug reactions associated with ravulizumab: a retrospective pharmacovigilance study utilizing the FAERS database.
Frontiers in immunologyNeuro-ophthalmic presentation of leptomeningeal metastasis of thymoma: a case report.
Frontiers in neurologyCAR T cell therapy in autoantibody-mediated neurological disorders: a promising strategy.
Journal of neuroinflammationElucidating genetic backgrounds of myasthenia gravis in Japanese by genome-wide association studies and multi-omics analyses of thymoma.
Nature communicationsMyasthenic Crisis Unmasking Myocardial Infarction with Nonobstructive Coronary Arteries in a Patient with Undiagnosed Myasthenia Gravis.
The Journal of the Association of Physicians of IndiaIndirect Comparison of Nipocalimab Versus Efgartigimod and Rozanolixizumab in the Treatment of Generalized Myasthenia Gravis.
Advances in therapyJuvenile Myasthenia Gravis: An Indian Perspective.
Neurology IndiaAdvantages of negative-pressure suction device compared to traditional chest closed drainage in the management of patients after mediastinal mass resection.
Journal of thoracic diseaseConcurrent Nivolumab-Induced Myocarditis and Myasthenia Gravis: A Case Report.
Case reports in oncological medicineIsolated dysphagia masking myasthenia gravis diagnosis.
Arquivos de neuro-psiquiatria[Clinical characteristics and genetic analysis of a patient with Kennedy disease with secondary infertility as the initial symptom].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical geneticsCase Report: Positioning head tilt observed in six dogs with meningoencephalitis of unknown origin.
Frontiers in veterinary scienceApplication of Droplet Digital PCR in Sputum Samples in Myasthenia Gravis Patients with Pneumonia.
Infection and drug resistanceLate-Onset Ocular Myasthenia Gravis-Like Symptoms During Erenumab Therapy for Chronic Migraine: A Case Report.
Biologics : targets & therapySingle-stage concomitant extended thymectomy for myasthenia gravis and enucleation of a left recurrent laryngeal nerve schwannoma via median sternotomy.
General thoracic and cardiovascular surgery casesCaring beyond the procedure: a qualitative study on thoracic surgery nurses' perspectives on chronic illness experiences of individuals with myasthenia gravis undergoing thymectomy.
BMJ openQuality and reliability of myasthenia gravis-related short videos on TikTok and Bilibili: A cross-sectional study.
Digital healthClinical and electrophysiological characteristics of myasthenia gravis patients with concomitant type 2 diabetes mellitus.
Frontiers in neurologyCholinergic Crisis Associated With Standard-Dose Pyridostigmine in a Hemodialysis Patient With Ocular Myasthenia Gravis and Marked Weight Loss.
CureusSeizure as an Atypical Presentation of Myasthenia Gravis: A Rare but Critical Diagnostic Challenge.
Clinical case reportsAstragaloside IV ameliorates experimental autoimmune myasthenia gravis through multi-target regulation of immune-microbiota-metabolism network and ferroptosis inhibition.
Pathology, research and practiceExperience Using Efgartigimod to Treat Juvenile Myasthenia Gravis in China: A Multicenter Retrospective Study.
Muscle & nerveIncreased Prevalence of Extrathymic Neoplasms in Myasthenia Gravis Patients-A Population-Based, Matched Case-Control Study.
Muscle & nerveClinical and economic outcomes of therapeutic plasma exchange and intravenous immunoglobulin for treating adults with autoimmune neurological disorders: a systematic review and meta-analysis.
BMC neurologyCloudy or Clear? Readability and Content Analysis of Patient Education Materials in Myasthenia Gravis.
Muscle & nerveMyasthenia gravis and pregnancy: a systematic review and meta-analysis.
Journal of neurologyEfficacy and safety of telitacicept for myasthenia gravis in real-world practice and exploratory outcomes in the elderly subgroup.
Clinical immunology (Orlando, Fla.)Neoadjuvant BO-112 and hypofractionated radiation therapy with or without nivolumab in soft tissue sarcoma: preclinical and phase 1 results.
Cancer discovery[Diagnosis of myasthenia gravis in a patient with polymyositis].
Zhurnal nevrologii i psikhiatrii imeni S.S. KorsakovaPhysical and respiratory training in patients with myasthenia gravis: a systematic review with meta-analysis.
Scientific reportsEarly-Onset Immune Checkpoint Inhibitor-Induced Myasthenia Gravis Following First-Cycle Pembrolizumab: Diagnostic Challenges and Management Strategies.
CureusRapidly Progressive Overlap of Immune Checkpoint Inhibitor-Induced Myositis and Myasthenia Gravis: Diagnostic and Therapeutic Challenges.
CureusNon-Motor Symptoms in Myasthenia Gravis Patients: Evaluation of Auditory and Olfactory Functions.
Noro psikiyatri arsiviEvaluation of Muscle Oxygenation by Functional Near-Infrared Spectroscopy in Patients with Myasthenia Gravis During Rest and Exercise.
Noro psikiyatri arsiviElevated serum Interleukin-39 in Myasthenia gravis: a possible biomarker.
European journal of medical researchDistinguishing pharmacological toxicity from disease severity and lifestyle confounders in myasthenia gravis comorbidity models.
Journal of the neurological sciencesGiant cell myositis confined to the lower extremities without associated thymoma or myasthenia gravis: a case report.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of MyologyEfficacy and safety of immunosuppressants and immunomodulators in juvenile myasthenia gravis: a systematic review and meta-analysis.
Journal of translational medicineZilucoplan is effective for ravulizumab-refractory generalized myasthenia gravis with the C5 p.Arg885His variant: a case report.
Neuromuscular disorders : NMDRobot-assisted versus video-assisted surgery for early functional recovery in patients with non-small-cell lung cancer: a systematic review and meta-analysis of propensity score-based matching studies.
Journal of robotic surgeryEffective Use of the Thoracolumbar Interfascial Plane Block With Total IV Anesthesia for Laminoplasty in a Patient With Myasthenia Gravis: A Case Report.
CureusRapid Symptomatic Improvement and Long-Term Minimal Symptom Expression in a Myasthenia Gravis Patient Treated With Zilucoplan Without Maintenance Cholinesterase Inhibitors, Corticosteroids, or Immunosuppressants: A Case Report.
CureusEmergency use of eculizumab in impending and manifest myasthenic crisis: a retrospective case series.
Therapeutic advances in neurological disordersMiglustat: a first-in-class enzyme stabilizer for cipaglucosidase alfa for the treatment of late-onset Pompe disease.
Therapeutic advances in rare diseaseThe temporal sequence of myasthenia gravis and neuromyelitis optica spectrum disorder: a case report and systematic review of 74 patients.
Frontiers in neurologyReal-World Evaluation of Efgartigimod in Generalized Myasthenia Gravis: A Single-Center Experience.
Journal of clinical neuromuscular diseaseA Novel Truncating Pathogenic Variant in RRM2B in a Kurdish Family With Autosomal-Dominant Chronic Progressive External Ophthalmoplegia Plus (PEOA5).
Journal of clinical neuromuscular diseaseIsolated bilateral facial palsy as the initial presenting manifestation of generalized myasthenia gravis preceding myasthenic crisis.
NeurologiaSuccessful prehospital resuscitation of a young female patient with myasthenia gravis experiencing cardiopulmonary arrest due to complete airway obstruction: a case report and review of the literature.
Journal of medical case reportsTriple M syndrome (myasthenia gravis, myocarditis and myositis) following atezolizumab in small cell lung carcinoma.
BMJ case reportsRethinking rituximab in neuroimmunology: Real-world efficacy, cost-effectiveness, and long-term remission.
Journal of neuroimmunologyProgress in the Treatment of Refractory Myasthenia Gravis.
Revista de neurologiaThe Relationship Between Immune Semaphorins and Myasthenia Gravis.
Brain and behaviorEarly versus late add-on therapy in generalized myasthenia gravis: a multicenter real-world cohort study.
Journal of neurologySingle-cell RNA-sequencing of myasthenia gravis reveals transcriptional heterogeneity and dysfunction of immune cell populations.
International immunologyAssociation between vaccination and myasthenia gravis: a systematic review and meta-analysis.
Frontiers in immunologyAdverse Childhood Experiences and Psychological Health in Patients with Myasthenia Gravis: A Study Incorporating an Online Positive Mental Health Learning Program.
Healthcare (Basel, Switzerland)Single-cell profiling of immune reset in patients with refractory generalized myasthenia gravis receiving autologous CD19/BCMA CAR-T cell therapy.
Med (New York, N.Y.)Current status and challenges of biologic targeted therapy for myasthenia gravis in China.
Intractable & rare diseases researchCase Report: Thymoma-associated myasthenia gravis, myositis, myocarditis, and anti-GAD65 autoimmune encephalitis: a unique case of paraneoplastic polyautoimmunity.
Frontiers in immunologySafety and Effectiveness of Eculizumab in Patients With Refractory Ocular or Ocular-Predominant Myasthenia Gravis: A Case Series.
Muscle & nerveImmunotherapy Safety in Thymic Epithelial Tumors: Disproportionality Analysis of the Food and Drug Administration Adverse Event Reporting System.
JMIR cancerClinical course and prognosis of chronic autoimmune neuropathies requiring intensive care: a retrospective cohort study.
Journal of neurologyA comprehensive electrooculography measurement system and protocols for screening myasthenia gravis.
MethodsXTelitacicept for refractory AChR-positive generalized myasthenia gravis: a retrospective real-world study.
Frontiers in immunologyOutcomes of preoperative medical consultations for elective non cardiac surgical procedures at tertiary care center.
Pakistan journal of medical sciencesSimultaneous Diagnosis of Myasthenia Gravis and Neurosyphilis, With Symptoms Improving After Neurosyphilis Treatment: A Case Report.
CureusHigh expression of IRF8 in AChR-specific cells regulates the function of B cells.
Immunology lettersAre you weary of illness? Coping and existential positioning in life with myasthenia gravis.
Medicine, health care, and philosophyReal-World Outcomes of Efgartigimod in Adult Myasthenia Gravis.
CureusDifferential response to ofatumumab in anti-AChR and anti-MuSK positive myasthenia gravis patients: a single-center retrospective study.
Therapeutic advances in neurological disordersImmune Dysregulation: Navigating Autoimmune Disorders in Exotic Companion Animals.
The veterinary clinics of North America. Exotic animal practiceCurrent evidence and knowledge gaps in family planning and pregnancy in myasthenia gravis, NMOSD, and MOGAD.
The Lancet. NeurologyPregnancy and antibody-mediated diseases: evidence and gaps.
The Lancet. Neurology[A drooping gaze, a cold clue: Late-onset presentation of myasthenia gravis].
Revista espanola de geriatria y gerontologiaPatient Perceptions of Needs and Expectations Regarding the Current Management of Myasthenia Gravis: A Biopsychosocial Study.
Neurology and therapyMyasthenia Gravis With Acetylcholine Receptor Antibodies in the Very Old: Treatment Challenges and Diagnostic Pitfalls.
European journal of neurologyCombined adapted physical activity and art-therapy intervention in myasthenia gravis: Study protocol for a randomized crossover pilot trial.
Contemporary clinical trialsLow Prevalence and Inconsistency of LRP4-IgG Detection in Suspected Myasthenia Gravis: A Multicenter CBA Comparison.
Neurology(R) neuroimmunology & neuroinflammationNationwide trends in mediastinal tumor and myasthenia gravis surgery in Japan: a decade claims-based analysis (2014-2023).
International journal of clinical oncologyOutcomes following single-level lumbar fusion in patients with myasthenia gravis.
Journal of orthopaedicsThe role and mechanism of IL‑35 in myasthenia gravis (Review).
International journal of molecular medicineAssessment of Voice and Speech attributes in Adult Patients with Myasthenia Gravis. A case control study.
Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)Inflammatory biomarker panels in peripheral blood: association with myasthenia gravis onset and severity.
Frontiers in neurologyMonocyte-macrophage SAMHD1 alleviates EAMG by modulating the cGAS-STING pathway.
Journal of neuroinflammationQiangji Jianli Decoction attenuates skeletal muscle injury in rats with experimental autoimmune myasthenia gravis via the GRP78/IRE1α/GPX4 signaling pathway.
Journal of ethnopharmacologyClinical response to therapeutic plasma exchange in patients with immune-mediated inflammatory diseases of the central nervous system.
Anales de pediatriaThe Duke MG Patient Registry III. Comparative Effectiveness of Azathioprine and Mycophenolate Mofetil in Generalized Myasthenia Gravis, a Retrospective Single Center Review.
Muscle & nerveFirst Paediatric Case of mRNA COVID-19 Vaccine Associated New Onset Systemic Myasthenic Crisis.
Sisli Etfal Hastanesi tip bulteniClinical outcomes, serum IgG changes, and follow-up observations in the treatment of anti-AChR antibody-positive generalized myasthenia gravis with Efgartigimod.
BMC neurologyRapid efficacy of efgartigimod for generalized myasthenia gravis patients in acute exacerbations/worsening: multicenter real-world retrospective study.
Journal of neurology[Is it myasthenia gravis?].
MMW Fortschritte der MedizinVibostolimab coformulated with pembrolizumab versus pembrolizumab alone as adjuvant therapy for high-risk stage IIB-IV melanoma (KEYVIBE-010): a randomised, double-blind, phase 3 study.
The Lancet. OncologyThymectomy with or without maintenance therapy for myasthenia gravis patients: a tri-center, real-world study.
Therapeutic advances in neurological disordersCase-Based Lessons on Remote Patient Monitoring in Neurology Using Consumer-Grade Wearables.
Journal of central nervous system diseaseGenetic insights into biological aging and myasthenia gravis: a Mendelian randomization study of telomere length, epigenetic clocks, and mitochondrial DNA copy number.
Clinical epigeneticsDocosahexaenoic acid supplementation aggravates myasthenia gravis through immune dysregulation.
Journal of neuroimmunologyMendelian randomization followed by single-cell RNA sequencing exploration identifies effector memory CD4+ T cells as a risk factor for myasthenia gravis.
MedicineFactors Influencing the Conversion of Ocular Myasthenia Gravis to Generalized Myasthenia Gravis: A Retrospective Cohort Study.
Journal of ophthalmologyC-Reactive Protein and Neurological Autoimmune Diseases: Bridging the Diagnostic and Pathogenic Gap.
International journal of molecular sciencesLong-Term Response Without Immune-Related Adverse Events to Atezolizumab Treatment in TMB-High Thymoma: A Case Report from the KOSMOS-II Study.
Journal of clinical medicinePerceived Fatigue and Associated Psychological Factors in Patients with Myasthenia Gravis.
Healthcare (Basel, Switzerland)Associations between myasthenia Gravis and outcomes following cardiac surgery: an analysis of the nationwide inpatient sample.
BMC anesthesiologyTakotsubo cardiomyopathy in myasthenia gravis: a systematic review of case reports with subtype-based analysis.
International journal of emergency medicinePostoperative hormonal modulation in a patient with granulosa cell tumor and myasthenia gravis: a gyneco-oncologic perspective.
Annals of medicine and surgery (2012)Telitacicept demonstrates high probability of efficacy in myasthenia gravis: a Bayesian real-world study.
Frontiers in neurologyImmuno-deficient features of thymoma-associated myasthenia gravis patients with hypogammaglobulinemia: A condition comparable to Good's syndrome.
Journal of neuroimmunologyAssociated Autoimmunity in Myasthenia Gravis in Denmark: A Nationwide Case-Control Study.
European journal of neurologyDiphtheria Presenting With Cranial Neuropathy: The Patch Unseen.
CureusThe Differential Diagnosis of Diplopia.
Deutsches Arzteblatt internationalApplication analysis of transfected cell method for detecting AChR antibodies in MG patients.
Scientific reportsAcute Myasthenic-Like Illness: A Common Presentation of Neurotoxic Snakebite in a Tropical Region.
The American journal of tropical medicine and hygieneImmune Checkpoint Inhibitor-Related Myositis and Associated Triad Overlap Syndrome.
Arthritis care & researchDiagnostic performance and safety of the edrophonium test in myasthenia gravis: a retrospective case-control study.
Neurological research and practiceComparative outcomes of robotic- and video-assisted thoracoscopic surgery in thymectomy: a systematic review of implications for myasthenia gravis remission and long-term oncology.
Journal of thoracic diseaseAI-driven biomarker learning for the early diagnosis of neurodegenerative diseases: ABLEDx.
Journal of nanobiotechnologyLymphocyte alterations and elevated complement signaling are key features of refractory myasthenia gravis.
Med (New York, N.Y.)Longitudinal MuSK antibody levels may correlate with disease severity in MuSK myasthenia gravis.
Journal of neuroimmunologyLetter to editor: Early real-life experience on zilucoplan for generalized myasthenia gravis: ZILU25 multicenter observational study.
Journal of the neurological sciencesReal-world use of efgartigimod in acetylcholine receptor antibody-positive generalized myasthenia gravis: experience from two centers in Greece and Cyprus.
Frontiers in neurologyMyasthenia gravis following the initiation of statin therapy: A multinational self-controlled case series study.
Journal of internal medicineFusion of deep learning and radiomics with dynamic spatiotemporal modeling for non-small cell lung cancer recurrence risk assessment after microwave ablation.
BMC medical imagingIncidence and clinical characteristics of concurrent thyroid eye disease and ocular myasthenia gravis.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologieGlobal Research Landscape in T Cells and Myasthenia Gravis: Trends, Collaborations, and Future Directions.
Molecular neurobiologyMultisystemic Malakoplakia Revealed by 18F-FDG PET/CT: A Case of Concomitant Bilateral Osteomyelitis and Genitourinary Involvement.
Clinical nuclear medicineIncidental finding of "H"-type duplex gallbladder: a case report.
Journal of medical case reportsEvaluation of neuromuscular blocker use in myasthenia gravis patients undergoing rapid sequence intubation.
The American journal of emergency medicineNeurologists' decision-making in the management of generalised myasthenia gravis: Therapeutic inertia and treatment choices.
Journal of neuromuscular diseasesDelayed recovery following myasthenic exacerbation and subsequent endplate-protecting treatment.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyFrequent co-occurrence of AChR-positive myasthenia gravis in facioscapulohumeral muscular dystrophy suggests a novel disease association.
Journal of neurology, neurosurgery, and psychiatryImproved Neuromuscular Transmission Following Thymectomy in Juvenile Myasthenia Gravis: A Case Series.
Muscle & nerveSuccessful use of immune checkpoint Inhibition in a patient with myasthenia gravis and recurrent endometrial cancer- expanding access beyond initial clinical trial eligibility.
Gynecologic oncology reportsSafety of home administration of cipaglucosidase alfa plus miglustat in late-onset Pompe disease: results from multiple clinical trials.
Therapeutic advances in rare diseaseElectrodiagnostic Approach to Defects of Neuromuscular Transmission.
Muscle & nerve[Myasthenic syndromes: retrospective analysis of two patient cohorts].
Fortschritte der Neurologie-PsychiatrieRozanolixizumab-induced aseptic meningitis in AChR-thymoma associated myasthenia gravis.
Acta neurologica BelgicaCorticosteroid-Refractory Juvenile Myasthenia Gravis: Treatment Responses and Prognosis in a Large Chinese Cohort.
Muscle & nerveClinical characteristics and treatment outcomes in thymoma- related aplastic anemia: a case report and literature review.
Journal of cardiothoracic surgerySerum from patients with acetylcholine receptor antibody-positive myasthenia gravis triggers pathogenic changes in human myotube cells.
Journal of neuroimmunologyLow-dose IL-2 Ameliorates Experimental Autoimmune Myasthenia Gravis in Rats by Restoring the CD4-positive Helper T-cell Balance Via the JAK/STAT5 Pathway.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune PharmacologyIatrogenic botulism: a risk for botulinum toxin's medical use?
Journal of neural transmission (Vienna, Austria : 1996)Fc receptor-like proteins and their role in B-cell responses and autoimmune diseases.
Immunology lettersMulti-omics profiling reveals intrathymic triggers and novel biomarkers in thymoma-associated myasthenia gravis.
Biomarker researchEfgartigimod for steroid-resistant autoimmune glial fibrillary acidic protein astrocytopathy: a case report and literature review.
Journal of neuroimmunologyENGAGE: Analyzing the value of virtual reality in a patient-centric immersive learning program in myasthenia gravis for healthcare professionals.
Frontiers in neurologyAzathioprine Toxicity in Patients With Myasthenia Gravis: A Single Center Experience.
Muscle & nerveExploring the impact of age of onset on stereoacuity in patients with myasthenia gravis.
Frontiers in ophthalmologyThe rare report of unicentric Castleman disease with concurrent myasthenia gravis and paraneoplastic pemphigus: a case report with a focused review of the literature.
Frontiers in oncologyFracture Occurrence Within FRAX-Defined High-Risk Myasthenia Gravis: An Exploratory Stratification by Age and Activities of Daily Living.
Journal of clinical medicineA Shift from Standard Median Sternotomy to Robotic-Assisted Thoracic Surgery for Resection of Anterior Mediastinal Tumors.
Journal of clinical medicineGut Microbiota as Neuroimmune Modulators in Myasthenia Gravis: Mechanistic Insights from the Gut-Brain Axis to Therapeutic Innovations.
The American journal of Chinese medicineAssessing the Value Contribution of Vyvgart® (Efgartigimod Alfa) in the Treatment of Generalized Myasthenia Gravis with Acetylcholine Receptor Antibody in Spain Through Multi-criteria Decision Analysis.
Advances in therapy1-Year Clinical Outcome Post-Myasthenic Crisis: A Multicenter Prospective Study in China.
European journal of neurologyAberrant expression of triggering receptor expressed on myeloid cell-1 is involved in the immunopathological mechanism of myasthenia gravis.
AutoimmunityAdd-on efgartigimod in myasthenic crisis: a promising treatment option.
Frontiers in neurologyEfgartigimod combined with rituximab helps improve the symptoms and reduce the use of corticosteroids in patients with MuSK antibody-positive MG: a single case report.
Frontiers in immunologyExploring Pembrolizumab-Induced IM3OS in a Patient With Bladder Cancer.
Pharmacology research & perspectivesAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Fundada em 1984 como Associação dos Miastênicos do Brasil.
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Half a century of change: demographic trends and their clinical impact in acetylcholine receptor antibody-positive myasthenia gravis.
- Neuro-immune interactions underlying autoimmune diseases: insights from brain imaging data.
- Morvan syndrome in a patient with progressing metastatic thymoma and myasthenia gravis.
- Risk of New-Onset Myasthenia Gravis Following COVID-19 Infection and Vaccination: A Population-Based Case-Control Study.
- Minimal Symptom Expression in Generalized Myasthenia Gravis: A Valuable Patient-Centric Treatment Goal.
- Massive Bilateral Pulmonary Embolism Presenting as Isolated Abdominal Pain: An Atypical Presentation and Incidental Detection in Dual Immune-Mediated Disease.
- Exploring medication adherence and illness perception in patients with neuroimmune diseases: a cross-sectional study.
- Case report: Efgartigimod combined with intravenous methylprednisolone in a case of co-occurrence of unexplained myasthenia gravis, inflammatory myopathy, and fulminant myocarditis.
- Adaptive Therapeutic Plasma Exchange Technologies in Low-resource Settings: Utilization, Safety, and Clinical Insights from 2507 Neurological Cases.
- Differential Toxicity of Immune Checkpoint Inhibitors in Older Adults: A Large-Scale, Propensity Score-Matched Real-World Analysis.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:589(Orphanet)
- OMIM OMIM:254200(OMIM)
- MONDO:0009688(MONDO)
- Miastenia Gravis(PCDT · Ministério da Saúde)
- GARD:7122(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q8285(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
