Raras
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Aspergilose
ORPHA:1163CID-10 · B44.0CID-11 · 1F20DOENÇA RARA

Aspergilose é uma infecção, um crescimento de fungos ou uma reação alérgica causada pelo fungo Aspergillus. Existem vários tipos diferentes de aspergilose. Um tipo é a aspergilose broncopulmonar alérgica (também conhecida como ABPA), uma condição onde o fungo causa sintomas respiratórios alérgicos parecidos com os da asma, como chiado no peito e tosse, mas que não chega a invadir e destruir os tecidos. Outro tipo de aspergilose é a aspergilose invasiva. Essa infecção geralmente atinge pessoas com o sistema imunológico enfraquecido devido a câncer, AIDS, leucemia, transplante de órgãos, quimioterapia, ou outras condições ou situações que diminuam a quantidade de glóbulos brancos normais. Nessa condição, o fungo invade e danifica os tecidos do corpo. A aspergilose invasiva afeta mais comumente os pulmões, mas também pode causar infecção em muitos outros órgãos e se espalhar pelo corpo (atingindo frequentemente os rins e o cérebro). Aspergiloma, um crescimento (bola de fungos) que se desenvolve em uma área do pulmão que já teve alguma doença, como tuberculose ou abscesso pulmonar, é um terceiro tipo de aspergilose. Este tipo de aspergilose é formado por uma massa emaranhada de fibras do fungo, coágulos de sangue e glóbulos brancos. A bola de fungos cresce aos poucos, destruindo o tecido pulmonar no processo, mas geralmente não se espalha para outras áreas do corpo.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

Aspergilose é uma infecção, um crescimento de fungos ou uma reação alérgica causada pelo fungo Aspergillus. Existem vários tipos diferentes de aspergilose. Um tipo é a aspergilose broncopulmonar alérgica (também conhecida como ABPA), uma condição onde o fungo causa sintomas respiratórios alérgicos parecidos com os da asma, como chiado no peito e tosse, mas que não chega a invadir e destruir os tecidos. Outro tipo de aspergilose é a aspergilose invasiva. Essa infecção geralmente atinge pessoas com o sistema imunológico enfraquecido devido a câncer, AIDS, leucemia, transplante de órgãos, quimioterapia, ou outras condições ou situações que diminuam a quantidade de glóbulos brancos normais. Nessa condição, o fungo invade e danifica os tecidos do corpo. A aspergilose invasiva afeta mais comumente os pulmões, mas também pode causar infecção em muitos outros órgãos e se espalhar pelo corpo (atingindo frequentemente os rins e o cérebro). Aspergiloma, um crescimento (bola de fungos) que se desenvolve em uma área do pulmão que já teve alguma doença, como tuberculose ou abscesso pulmonar, é um terceiro tipo de aspergilose. Este tipo de aspergilose é formado por uma massa emaranhada de fibras do fungo, coágulos de sangue e glóbulos brancos. A bola de fungos cresce aos poucos, destruindo o tecido pulmonar no processo, mas geralmente não se espalha para outras áreas do corpo.

Pesquisas ativas
27 ensaios
266 total registrados no ClinicalTrials.gov
Publicações científicas
18.137 artigos
Último publicado: 2026 Apr 14

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: B44.0
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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🫁
Pulmão
17 sintomas
🦴
Ossos e articulações
5 sintomas
🩸
Sangue
5 sintomas
🛡️
Imunológico
5 sintomas
🧠
Neurológico
2 sintomas
🫃
Digestivo
2 sintomas

+ 24 sintomas em outras categorias

Características mais comuns

90%prev.
Tosse
Muito frequente (99-80%)
90%prev.
Teste de 1,3 beta glucana no sangue positivo
Muito frequente (99-80%)
55%prev.
Dor torácica
Frequente (79-30%)
55%prev.
Opacificação em vidro fosco na TC de alta resolução pulmonar
Frequente (79-30%)
55%prev.
Escarro anormal
Frequente (79-30%)
55%prev.
Imunodeficiência
Frequente (79-30%)
66sintomas
Muito frequente (2)
Frequente (12)
Ocasional (25)
Muito raro (17)
Sem dados (10)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 66 características clínicas mais associadas, ordenadas por frequência.

TosseCough
Muito frequente (99-80%)90%
Teste de 1,3 beta glucana no sangue positivoPositive blood 1,3 beta glucan test
Muito frequente (99-80%)90%
Dor torácicaChest pain
Frequente (79-30%)55%
Opacificação em vidro fosco na TC de alta resolução pulmonarGround-glass opacification on pulmonary HRCT
Frequente (79-30%)55%
Escarro anormalAbnormal sputum
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico18.137PubMed
Últimos 10 anos200publicações
Pico2026180 papers
Linha do tempo
2026Hoje · 2026🧪 1991Primeiro ensaio clínico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
Aprovado1
3Fase 32
2Fase 23
·Pré-clínico14
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 20 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Aspergilose

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

18 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

NCT01386437 · Natural History of Individuals With Immune System Problems T…Recrutando
NCT07362693 · A Cohort Study of the Efficacy and Safety of Biologics in Pa…Recrutando
NCT07530770 · Real-World Effectiveness of Benralizumab in Allergic Broncho…Recrutando
NCT05444946 · Oral Itraconazole Versus Combination of Systemic Glucorticoi…Recrutando
NA
NCT07493629 · Immune Status and Disease Control of Inflammatory Airway Dis…Recrutando
NCT07362667 · A Study of the Efficacy and Safety of Bronchoscopic Airway C…Recrutando
NCT07313527 · PCR for Aspergillus Fumigatus in Blood and Bronchoalveolar L…Recrutando
NCT03828773 · PTX3-targeted Antifungal ProphylaxisRecrutando
NA
NCT03748069 · Influenza Associated Aspergillosis In-depth InvestigationRecrutando
NCT06794554 · Rezafungin for Treatment of Chronic Pulmonary Aspergillosis …Recrutando
PHASE2
NCT07040332 · Pathogenesis and Inflammatory Phenotype of Allergic Bronchop…Recrutando
NCT06244979 · iMagIng pulmonaRy Aspergillosis Using Gallium-68-dEferoxamin…Recrutando
PHASE2
NCT06537726 · Breath Analysis for the Detection of Invasive Fungal Infecti…Recrutando
NCT06885905 · Impact of Chronic Pulmonary Aspergillosis (CPA) on Health St…Recrutando
NCT05653193 · Interferon-gamma as Adjunctive Therapy in Chronic Pulmonary …Recrutando
PHASE2
NCT06174922 · A Randomized Trial of Prednisolone, Itraconazole, or Their C…Recrutando
PHASE3
NCT03717623 · Posaconazole Pharmacokinetics in Patients Receiving Chemothe…Recrutando
PHASE4
NCT03656081 · Chronic Pulmonary Aspergillosis and Ambisome Aerosol with It…Recrutando
PHASE3

Outros ensaios clínicos

266 ensaios clínicos encontrados, 27 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
7.713 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 7.713

#1

Chest X-ray prior to biological treatment in inflammatory bowel diseases: it is not only about tuberculosis - a case report and literature review.

European journal of gastroenterology &amp; hepatology2026 Mar 16

Este artigo enfatiza a crucialidade da radiografia de tórax (CXR) rotineira antes de iniciar tratamentos biológicos para doenças inflamatórias intestinais. Ele demonstra que a CXR pode detectar infecções pulmonares graves como a aspergilose — não apenas tuberculose — mesmo em pacientes sem sintomas evidentes, como ilustrado por um caso onde a detecção precoce evitou um desfecho potencialmente fatal. Para pacientes e médicos, isso ressalta que a CXR é uma ferramenta de segurança vital para identificar e tratar infecções ocultas antes que a imunossupressão aumente os riscos, guiando decisões clínicas e protegendo a vida do paciente.

🇧🇷 traduzido
#2

Synergistic effects of S100 calcium-binding protein A12 combined with Pentraxin 3 in invasive pulmonary aspergillosis and their clinical application prospects.

Frontiers in cellular and infection microbiology2026

A Aspergilose Pulmonar Invasiva (API) é uma infecção fúngica grave e crescente, cujo diagnóstico precoce é um desafio crucial devido às limitações dos métodos atuais. No entanto, este artigo destaca que as proteínas S100A12 e Pentraxina 3 (PTX3), atuando sinergicamente, representam uma promissora nova direção. Sua combinação pode aprimorar significativamente o diagnóstico precoce, a avaliação da progressão da doença e a otimização da terapia, oferecendo melhores perspectivas para pacientes e médicos.

🇧🇷 traduzido
#3

Unraveling the complexities: A comprehensive review of severe fever with thrombocytopenia syndrome and its associated complications.

iScience2026 Apr 17

A Síndrome da Febre Severa com Trombocitopenia (SFTS) é uma infecção viral emergente transmitida por carrapatos, com alta morbidade e taxa de letalidade de até 30%, sendo crucial seu reconhecimento para pacientes em regiões endêmicas ou de expansão. Caracterizada por febre alta e redução de plaquetas, em casos graves, pode progredir rapidamente para complicações de risco de vida, como miocardite, distúrbios neurológicos e, notavelmente, aspergilose pulmonar invasiva (IPA), além de outras infecções secundárias e falência múltipla de órgãos, exigindo atenção médica imediata e vigilância para um prognóstico melhor.

🇧🇷 traduzido
#4

Diagnosis, clinical features and survival analysis of invasive pulmonary aspergillosis among critically ill patients: a retrospective cohort study based on updated criteria.

Frontiers in cellular and infection microbiology2026

A aspergilose pulmonar invasiva (API) é uma complicação comum (7,1%) e letal em pacientes críticos com pneumonia na UTI, duplicando o risco de morte. O diagnóstico precoce é crucial, sendo o galactomanano no lavado broncoalveolar (BALF GM), especialmente combinado com testes moleculares, o método mais eficaz. Para melhorar a sobrevida, é vital iniciar a terapia antifúngica rapidamente e considerar a traqueostomia, pois estas intervenções demonstraram ser independentemente associadas a melhores resultados.

🇧🇷 traduzido
#5

Amphotericin B promotes respiratory viral entry by enhancing late endosomal maturation and fusion via glucocerebrosidase-mediated ceramide remodeling.

Nature communications2026 Mar 09

Este estudo crucial revela que a Anfotericina B, um antifúngico comum para a aspergilose pulmonar invasiva, paradoxalmente facilita a entrada de vírus respiratórios como influenza e SARS-CoV-2 nas células. Em pacientes, o uso de Anfotericina B foi associado a uma incidência significativamente maior de infecções virais subsequentes, o que sugere a necessidade de reavaliar cuidadosamente a terapia antifúngica para guiar decisões clínicas e potencialmente buscar novas estratégias antivirais.

🇧🇷 traduzido

Publicações recentes

Ver todas no PubMed

📚 EuropePMC10.090 artigos no totalmostrando 200

2026

Case Report: Rare Multidrug-Resistant Enterobacter Cloacae Complicated by Invasive Pulmonary Aspergillosis in an Elderly Patient with Advanced Lung Adenocarcinoma Treated with Osimertinib.

Infection and drug resistance
2026

Coexistence of pulmonary aspergillosis and cryptococcosis following treatment for SARS-CoV-2 infection in a kidney transplant recipient: a rare case report and literature review.

BMC nephrology
2026

Chest X-ray prior to biological treatment in inflammatory bowel diseases: it is not only about tuberculosis - a case report and literature review.

European journal of gastroenterology &amp; hepatology
2026

Case Report: Lung squamous cell carcinoma mimicking recurrent aspergillosis in systemic lupus erythematosus.

Frontiers in medicine
2026

Synergistic effects of S100 calcium-binding protein A12 combined with Pentraxin 3 in invasive pulmonary aspergillosis and their clinical application prospects.

Frontiers in cellular and infection microbiology
2026

Pharmacist-Led Full-Course Pharmaceutical Care Model in Allergic Bronchopulmonary Aspergillosis: A Case Report-Based Approach to Optimizing Multidisciplinary Management.

Infection and drug resistance
2026

Environmental and Phylogenetic Investigations of Aspergillus flavus Outbreak Linked to Contaminated Building Materials, Denmark, 2025.

Emerging infectious diseases
2026

From Aspergillus fumigatus pathogen surveillance to Aspergillus disease surveillance.

The Journal of hospital infection
2026

High-Volume Culture Improves Diagnostic Yield of Aspergillus Species From Sputum.

Mycoses
2026

Primary Cutaneous Aspergillosis Due to Aspergillus flavus in an Immunocompetent Patient.

Infection and drug resistance
2026

One-year clinical, radiological, and functional outcomes following antifungal therapy for aspergillus infection in lung transplant recipients.

JHLT open
2026

Unraveling the complexities: A comprehensive review of severe fever with thrombocytopenia syndrome and its associated complications.

iScience
2026

Diagnostic Performance of Sōna GM LFA in Pulmonary Infections Caused by Different Aspergillus Species.

Mycoses
2026

Diagnostic and prognostic value of serum miR-155 in chronic obstructive pulmonary disease.

Scientific reports
2026

[Allergic bronchopulmonary aspergillosis in internal medicine].

La Revue de medecine interne
2026

A Case of Disseminated Trichophytosis With Vascular Invasion and Multiple Ulcers: Case Report and Literature Review.

The Journal of dermatology
2026

Invasive Pulmonary Aspergillosis: Not Everything that Glitters is Cancer.

Open respiratory archives
2026

Pulmonary mycoses: a clinical perspective.

Breathe (Sheffield, England)
2026

Increased serum antibody responses to Aspergillus fumigatus and house dust mite antigens in dogs with idiopathic eosinophilic bronchopneumopathy.

Journal of veterinary internal medicine
2026

Evaluation of the Prognostic Value of PCR Cycle Threshold and Mortality in Pulmonary Aspergillosis: A Retrospective Cohort Study.

Infection and drug resistance
2026

Pseudomonas aeruginosa adaptation and persistence in the aspergilloma microbiome revealed by integrated multi-omics.

G3 (Bethesda, Md.)
2026

Successful Long-Term Use of Isavuconazole in a Tacrolimus-Treated Japanese Kidney Transplant Recipient With Disseminated Cryptococcosis and Probable Invasive Aspergillosis.

Cureus
2026

Accelerated mutator phenotype in a clinical Aspergillus fumigatus isolate contributes to adaptive evolution.

Emerging microbes &amp; infections
2026

Evidence that increased azole persistence and stress resistance precede the in vivo evolution of azole resistance in Aspergillus fumigatus.

Microbiology spectrum
2026

Continuous Renal Replacement Therapy for Patients With Sepsis in a Low-Resource Medical Intensive Care Unit (MICU): Incidence, Risk Factors, and Outcomes.

Cureus
2026

Asthma and Allergic Bronchopulmonary Aspergillosis: Understanding, Insights, and State-of-the-Art.

Journal of inflammation research
2026

Nebulised antifungal therapy in allergic bronchopulmonary aspergillosis in a patient with treatment-limiting comorbidities.

Medicina clinica
2026

Video-assisted thoracoscopic segmentectomy is feasible, safe and effective in selected cases of pulmonary aspergilloma.

The Indian journal of tuberculosis
2026

Rapid antifungal susceptibility testing for Aspergillus fumigatus using a loop-mediated isothermal amplification method.

Journal of microbiological methods
2026

Spore Wars: A Comprehensive Review of Pulmonary Aspergilloma and Its Clinical Management.

Chest
2026

Post-Lobectomy Pleural Aspergillosis with Bronchopleural Fistula in a Patient with Metastatic Synovial Sarcoma of the Lung: A Case Report.

Journal of clinical medicine
2026

Prevalence and Factors Associated With Aspergillus galactomannan Antigenemia Among People With Advanced HIV Disease in Uganda, 2023.

Open forum infectious diseases
2026

[Comparative bronchoscopic manifestations in pulmonary mucormycosis and invasive pulmonary aspergillosis].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
2026

Nosocomial invasive Aspergillus calidoustus infection in a CAR-T cell-treated patient with concomitant Aspergillus fumigatus respiratory infection.

European journal of clinical microbiology &amp; infectious diseases : official publication of the European Society of Clinical Microbiology
2026

Extracorporeal membrane oxygenation therapy for severe influenza-associated pulmonary aspergillosis: a case report.

Frontiers in medicine
2026

Clinical classification of chronic obstructive pulmonary disease with invasive pulmonary aspergillosis: a retrospective study.

Journal of thoracic disease
2026

Epidemiology of Aspergillosis Diagnoses in US Adults Using a National EHR Database, 2013-2023.

Open forum infectious diseases
2026

Stepwise, precision-based management of allergic Bronchopulmonary Aspergillosis/Mycosis: A real-life multicenter study.

Allergologia et immunopathologia
2026

Protocol for a systematic literature review and network meta-analysis of the evidence for therapies in allergic bronchopulmonary aspergillosis (ABPA).

Systematic reviews
2026

Antibiotic-induced microbiota disruption impairs neutrophil-mediated immunity to respiratory Aspergillus fumigatus infection in mice.

mBio
2026

Diagnosis, clinical features and survival analysis of invasive pulmonary aspergillosis among critically ill patients: a retrospective cohort study based on updated criteria.

Frontiers in cellular and infection microbiology
2026

Clinical value of sputum galactomannan testing in the diagnosis of invasive pulmonary aspergillosis among chronic obstructive pulmonary disease patients.

European journal of medical research
2026

Positivity rate of Aspergillus spp. in patients with tuberculosis-like symptoms in Yaoundé, Cameroon and antifungal resistance profile.

BMC infectious diseases
2026

Development and application of a rapid detection system for Aspergillus fumigatus based on ERA/CRISPR-Cas12a.

BMC microbiology
2026

Amphotericin B promotes respiratory viral entry by enhancing late endosomal maturation and fusion via glucocerebrosidase-mediated ceramide remodeling.

Nature communications
2026

Multiplex on-chip detection of Aspergillus by integrated ultrasonication-based bead beating lysis and magnetic beads direct amplification.

Frontiers in bioengineering and biotechnology
2026

How to safely discontinue antifungal treatment in invasive pulmonary aspergillosis? - Clinical considerations in haematology.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
2026

High total serum IgE level at diagnosis was associated with a progressive decline in lung function in asthmatic patients with allergic bronchopulmonary mycosis.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
2026

25 years of improvement in mortality in invasive aspergillosis in haematology patients: will it be sustained or is it under threat?

The Journal of antimicrobial chemotherapy
2026

Performance of the LDBio Aspergillus ICT lateral flow assay and western blot for diagnosing chronic pulmonary aspergillosis in post-tuberculosis patients: a prospective study from South India.

Microbiology spectrum
2026

Case report: intracranial fungal granuloma in a dromedary (Camelus dromedarius).

BMC veterinary research
2026

Biologics Use in Eosinophilic Lung Disease: Controversies and Consensus.

The journal of allergy and clinical immunology. In practice
2026

Differential Diagnosis of Eosinophilic Lung Diseases.

The journal of allergy and clinical immunology. In practice
2026

Invasive aspergillosis in liver transplant recipients in France (2007-21): a nationwide, retrospective, matched case-control study.

The Lancet. Microbe
2026

Oncostatin M receptor deficiency as a novel candidate genetic cause of autosomal recessive hyper-IgE syndrome.

Journal of human immunity
2026

Peripheral T-cell lymphoma-NOS presenting with cavitary lung lesions mimicking invasive aspergillosis.

BMJ case reports
2026

Treatment Monitoring and Outcome Prediction in Invasive Aspergillosis using Immunologic Markers.

The Journal of infectious diseases
2026

Beyond the Norm: Atypical Manifestations of Aspergillosis.

Respirology case reports
2026

Invasive Aspergillus Tracheobronchitis Presenting as Subglottic Stenosis: A Case Report.

Respirology case reports
2026

Novel cyp51A mutation profile in Aspergillus fumigatus from a patient with systemic lupus erythematosus and limited systemic sclerosis: first clinical case of acquired azole-resistance in Colombia.

BMC infectious diseases
2026

The chromatin remodeling factor Arp9 modulates drug-resistance and plays a key role in aflatoxins biosynthesis under mammalian-physiological-temperature in Aspergillus flavus.

PLoS pathogens
2026

Triple Calamity in a Smoker: Idiopathic Pulmonary Fibrosis, Chronic Pulmonary Aspergillosis, and Lung Adenocarcinoma.

Cureus
2026

Invasive Pulmonary Aspergillosis in a Young Adult With Hyperimmunoglobulin E Syndrome and Hypogammaglobulinemia Following Rituximab Therapy.

Cureus
2026

Integrative diagnosis of invasive pulmonary aspergillosis in non-neutropenic patients using BALF-tNGS-derived Aspergillus load and host risk factors: a multicenter study.

Frontiers in cellular and infection microbiology
2026

An Antifungal with a Novel Mechanism of Action Discovered via Resistance Gene-Guided Genome Mining.

ACS central science
2026

[A case of allergic bronchopulmonary aspergillosis complicated by pinworm infection in a child: immune interaction mechanism and stepwise treatment strategy].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
2026

Revisiting Sapronoses Through Aspergillosis.

Medical mycology journal
2026

Why do we urgently need a new treatment for cerebral aspergillosis?

Expert review of anti-infective therapy
2026

Identification of Aspergillus at section and species levels by artificial intelligence-based microscopic morphology image recognition.

Journal of clinical microbiology
2026

Auranofin and iodoquinol as promising repurposing drugs against filamentous fungi: antifungal activity and cellular alterations.

Microbiology spectrum
2026

Integrated bioinformatic analysis identifies ferroptosis-related biomarkers and subtypes in invasive aspergillosis.

Toxicology research
2026

Clinical Characteristics and Risk Factors for Chronic Pulmonary Aspergillosis in Patients with Nontuberculous Mycobacterial Pulmonary Disease.

Journal of clinical medicine
2026

Radiological Phenotypes of Bronchiectasis Based on Airway Generation.

Biomedicines
2026

Invasive Fungal Infections During Extracorporeal Membrane Oxygenation: A Case Series from Intensive Care Unit and Literature Review.

Diagnostics (Basel, Switzerland)
2026

Rapidly progressive intracranial infection consistent with aspergillosis, mimicking acute ischemic stroke.

Diagnostic microbiology and infectious disease
2026

Rapid and reliable diagnosis of mucormycosis using colorimetric loop-mediated isothermal amplification.

Journal of clinical microbiology
2026

Biomarkers in Invasive Pulmonary Fungal Infections: Where Do We Stand?

Journal of fungi (Basel, Switzerland)
2026

Radiologic Characterization of Invasive Fungal Infections of the Paranasal Sinuses and Skull Base: A Prospective Analysis.

Cureus
2026

Invasive aspergillosis in lung and heart transplant recipients.

JHLT open
2026

Clinical impact of chronic pulmonary aspergillosis in patients with pulmonary nontuberculous mycobacterial disease and colonization: a multicentre prospective cohort study.

Annals of medicine
2026

Performance Evaluation of the Chemiluminescence Immunoassay for Quantitative Detection of (1, 3)-β-D-glucan for Diagnosis of Invasive Fungal Diseases.

Medical mycology
2026

Pulmonary fungal infections in the age of biologics and climate change.

Current opinion in pulmonary medicine
2026

Association of follow-up chest computed tomography findings at 6 and 12 weeks with survival in people with invasive pulmonary aspergillosis following lung or allogeneic hematopoietic stem cell transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
2026

Active surveillance of cytomegalovirus and pulmonary aspergillosis in critically ill patients with COVID-19: risk assessment of high-dose steroids.

BMC infectious diseases
2026

Comparative performance of Filamentous Fungi 4.0 and Mass Spectrometry Identification 2.0 databases for Aspergillus spp.: identification using a simplified protein extraction method.

Revista do Instituto de Medicina Tropical de Sao Paulo
2026

The HosA histone deacetylase regulates stress resistance, host cell interactions, and virulence in Aspergillus fumigatus.

Microbiology spectrum
2026

Real-World Performance of Aspergillus and Mucorales Polymerase Chain Reaction Assays on Bronchoalveolar Lavage Fluid in Immunocompromised Children and Young Adults.

Journal of the Pediatric Infectious Diseases Society
2026

Case Report: Durable disease stability in a patient with MET exon 14 skipping mutation and brain metastasis NSCLC following radiotherapy and immunotherapy.

Frontiers in immunology
2026

Fluorodeoxyglucose (FDG)-Avid Upper-Lobe Mass Mimicking Malignancy in an Elderly Patient With Allergic Bronchopulmonary Aspergillosis: A Case Report.

Cureus
2026

Breakthrough invasive fungal infections during posaconazole prophylaxis in patients with hematologic malignancies at a tertiary care center - a 5-year audit from south India.

Indian journal of medical microbiology
2026

Nootkatone antifungal activity and calcium signaling-mediated resistance in Aspergillus fumigatus.

Applied microbiology and biotechnology
2026

Unravelling Voriconazole's Hepatic Metabolism: A Narrative Review on Factors Impacting Voriconazole-N-Oxide Exposure.

Mycoses
2026

Allergic bronchopulmonary aspergillosis in a patient without history of asthma: a case report.

Medical mycology case reports
2026

Whole-genome sequencing, phenotypic characterization, and antifungal susceptibility profiles of three Aspergillus hortae clinical isolates from Colombia.

PloS one
2026

Multiplex CRISPR/Cas9 editing of gliotoxin biosynthesis genes in Aspergillus fumigatus reduces pathogenicity in broilers.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
2026

Invasive pulmonary aspergillosis in the post-COVID-19 era: diagnosis, treatment, and what lies ahead.

Therapeutic advances in infectious disease
2026

How Should IgG Seroconversion to Aspergillus fumigatus be Interpreted in Children With Cystic Fibrosis.

Canadian respiratory journal
2026

Superselective Pulmonary Artery Embolization for Refractory Massive Hemoptysis Post-Bronchial Artery Embolization: A Bail-Out Measure.

Cardiovascular and interventional radiology
2026

Ubiquinone-based gene mutation and protein compactness of CoQ5 may contribute to a novel caspofungin resistance mode in Aspergillus flavus from pulmonary aspergillosis.

Diagnostic microbiology and infectious disease
2026

Virulence of Aspergillus flavus and relatives using the Galleria mellonella model.

Virulence
2026

[Chronic pulmonary aspergillosis as a complication of lung cavities and prednisolone treatment].

Ugeskrift for laeger
2026

Letter: Abdominal Wall Aspergillosis.

Surgical infections
2026

Cystic fibrosis complicated by allergic bronchopulmonary aspergillosis in a Chinese adolescent: a case report and literature review.

AME case reports
2026

Pulmonary aspergillosis diagnosed during surgical treatment for spontaneous pneumothorax: a case report.

AME case reports
2026

Isoimperatorin alleviates fungal keratitis by regulating NF-κB pathway and macrophage immune response.

Frontiers in immunology
2026

Post-tuberculosis lung disease and pulmonary aspergillosis management: challenges and considerations.

Expert review of anti-infective therapy
2026

Genome-wide discovery and phenotyping of non-coding transcripts in A. fumigatus reveals lncRNAs with a role in antifungal drug sensitivity.

Nature communications
2026

Fatal Fungal Peritonitis Caused by Aspergillus udagawae: An Autopsy Case Report.

Internal medicine (Tokyo, Japan)
2025

Subclavian mycotic aneurysm caused by Aspergillus flavus in a child with acute lymphoblastic leukemia: a case report.

Frontiers in pediatrics
2026

Milky Tea-Colored Pleural Effusion: Empyema Complicated by Pneumothorax Due to Mixed Infection With Mycobacterium tuberculosis and Aspergillus fumigatus.

The American journal of case reports
2026

Which trial do we need? Defining the optimal duration of antifungal therapy for invasive pulmonary aspergillosis.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
2025

Characteristics of T-lymphocyte subsets in patients with severe fever with thrombocytopenia syndrome complicated with invasive pulmonary aspergillosis: a retrospective study.

Frontiers in immunology
2026

A machine learning-based risk prediction tool for early identification of invasive pulmonary aspergillosis in immunocompetent patients: a systematic review and meta-analysis.

Journal of thoracic disease
2026

Serum Interleukin-8 for Differentiating Invasive Pulmonary Aspergillosis from Bacterial Pneumonia in Patients with HBV-Associated Acute-on-Chronic Liver Failure.

Journal of clinical and translational hepatology
2026

A clinically significant interaction between voriconazole and rifapentine: a case report and review of evidence.

Frontiers in medicine
2026

Time to re-evaluate combination antifungal therapy for invasive aspergillosis and other invasive mycoses.

The Lancet. Infectious diseases
2026

Mixed fungal infection in immunocompetent Dengue patient.

Indian journal of medical microbiology
2026

Allergic bronchopulmonary aspergillosis or tropical pulmonary eosinophilia: discriminatory potential of recombinant Aspergillus fumigatus antigens.

The journal of allergy and clinical immunology. In practice
2026

The double threat: bacterial and fungal co-/superinfection in viral pneumonia.

Expert review of respiratory medicine
2026

Primary Therapy for Invasive Aspergillosis With Triazoles or L-AmB: A Multicenter Retrospective Study.

Open forum infectious diseases
2026

[Invasive aspergillosis of the sphenoid sinus as a differential diagnosis in lesions of the sellar region].

Medicina
2026

Clinical Characteristics and Outcomes of Invasive Aspergillosis in Patients with Hematological Malignancies and Transplantation and Cellular Therapies in the Contemporary Era.

Mycopathologia
2026

From uncertainty to precision: stratifying the risk of invasive pulmonary aspergillosis in non-neutropenic patients with bacterial pneumonia.

Minerva anestesiologica
2026

Synergistic impact of Gram-negative bacterial co-infection on invasive pulmonary aspergillosis in non-neutropenic patients: a machine learning-based risk stratification approach.

Minerva anestesiologica
2026

Changes in the fungal ecology in the era of CFTR modulators: Results from a French multicentre study focused on cystic fibrosis airways.

Medical mycology
2025

Clinical features, diagnostic test performance, treatment and outcome of pulmonary tuberculosis patients with chronic pulmonary aspergillosis in China: a retrospective, observational study.

Frontiers in cellular and infection microbiology
2026

Misleading presentation of tuberculosis in a child with CGD revealing invasive aspergillosis: A molecularly confirmed case.

IDCases
2026

Characterization of a bZIP Transcription Factor ZipD in Aspergillus flavus.

Mycobiology
2026

Clinical and diagnostic misperception of tuberculosis and systemic fungal infections.

Journal de mycologie medicale
2026

Isolated right ventricular löffler endocarditis secondary to allergic bronchopulmonary aspergillosis.

European heart journal. Case reports
2026

Assessment of the performances of blood tests for the antemortem diagnosis of aspergillosis in wild or captive aquatic birds.

Veterinary research
2025

Concurrent Elevation of CEA and CA 19-9 in a Patient with Allergic Bronchopulmonary Aspergillosis: A Case Report and Literature Review.

Annals of clinical and laboratory science
2026

[Allergic bronchopulmonary aspergillosis-essential knowledge for radiology].

Radiologie (Heidelberg, Germany)
2026

Characteristics of individual cyp51A SNPs and combinations thereof impacting the azole phenotype in TR34-mediated resistance genotypes of Aspergillus fumigatus.

Antimicrobial agents and chemotherapy
2026

[New advances and future prospect in antifungal therapy for invasive pulmonary aspergillosis].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
2026

Mechanistic Insights into Calcium Oxalate Crystals in Aspergillosis of the Maxillary Sinus.

Head and neck pathology
2025

Immunocompromise and early-onset invasive pulmonary aspergillosis in viral pneumonia: a retrospective cohort study.

Frontiers in public health
2026

Development Framework of Desirability of Outcome Ranking Endpoints for Use in Clinical Trials of Invasive Fungal Diseases.

Open forum infectious diseases
2026

Concurrent pulmonary aspergillosis and phaeohyphomycosis due to Verruconis spp. in a stem cell transplant recipient with chronic graft-versus-host disease.

Medical mycology case reports
2026

CFTR modulators partially restore the epithelial interferome in Aspergillus infection to improve clinical outcome.

EBioMedicine
2026

Over-testing Galactomannan in patients with hematological malignancies: A retrospective analysis from a tertiary care university hospital in Türkiye.

Diagnostic microbiology and infectious disease
2026

Antifungal prophylaxis among critically ill COVID-19 patients: a meta-analysis and systematic review.

BMC infectious diseases
2026

Comorbidities in pediatric cystic fibrosis: ABPA, celiac disease and prediabetes in Georgia.

Respiratory medicine
2026

Invasive aspergillosis-related internal carotid artery occlusion diagnosed by thrombus pathology after mechanical thrombectomy.

Acta neurologica Belgica
2026

Tracheobronchial ulcers caused by Aspergillus infection is a potential cause of retrosternal pain: A case report and literature review.

The Journal of international medical research
2026

Invasive mold infection in heart transplant recipients: A nationwide multicenter matched case-control study between 2008 and 2022 in France.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
2026

Evaluation of an in vivo pulmonary aspergillosis model for triazole susceptibility breakpoint development.

Antimicrobial agents and chemotherapy
2026

Aspergillus Serology Predicts Relapse in Chronic Pulmonary Aspergillosis: Implications for Personalised Follow-Up Strategies.

Mycoses
2026

Diagnostic accuracy of Mucorales PCR testing in bronchoalveolar lavage fluid samples: a retrospective analysis of a prospectively collected cohort.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
2025

Seasonal variation in Aspergillus abundance in captive penguin burrow sands and its implication for aspergillosis risk in Japan.

Frontiers in veterinary science
2026

Secondary infections following tuberculosis: epidemiology, pathogenesis and clinical implications.

Breathe (Sheffield, England)
2026

Aspergillus fumigatus in mechanically ventilated pneumonia- independent mortality risk and synergistic microbiome signatures from a multicenter mNGS cohort.

BMC pulmonary medicine
2025

Chitosan-silver nanocomposites: promising alternatives for combating azole-resistant Aspergillus fumigatus.

Frontiers in cellular and infection microbiology
2025

Isavuconazole in the treatment of acute invasive fungal sinusitis: two case reports and literature review.

Frontiers in medicine
2026

Systemic Aspergillosis in Dogs: A Historical and Current State-of-the-Art Review.

Veterinary sciences
2026

Novel Genetic Diversity and Geographic Structures of Aspergillus fumigatus (Order Eurotiales, Family Aspergillaceae) in the Karst Regions of Guizhou, China.

Microorganisms
2025

The RNA-Binding Protein KSRP Is a Negative Regulator of Innate Immunity.

Biomolecules
2026

First Case of Cutaneous Coinfection with Aspergillus flavus and Klebsiella pneumoniae: Case Report and Literature Review.

Diagnostics (Basel, Switzerland)
2026

Anti-inflammatory therapies for bronchiectasis.

Current opinion in infectious diseases
2026

A One Health Perspective on Aspergillus fumigatus in Brazilian Dry Foods: High Genetic Diversity and Azole Susceptibility.

Journal of fungi (Basel, Switzerland)
2026

Early Antifungal Treatment in Immunocompromised Patients, Including Hematological and Critically Ill Patients.

Journal of fungi (Basel, Switzerland)
2026

Phase 2, open-label, noncomparative clinical trial evaluating safety and efficacy of posaconazole in pediatric patients with proven/probable invasive aspergillosis or possible invasive fungal disease.

Antimicrobial agents and chemotherapy
2026

Systemic isosporosis (atoxoplasmosis) in American robins (Turdus migratorius) in the southeastern United States.

International journal for parasitology. Parasites and wildlife
2026

Disseminated Invasive Aspergillosis in a Young Patient With Chronic Alcohol Use and Seemingly Preserved Immunocompetence: A Case Report.

Clinical case reports
2025

Unmasking Invasive Pulmonary Aspergillosis: Insights From a Case Series at a Tertiary Care Center.

Cureus
2026

Common inflammatory markers predict risk of ABPA development in children with cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
2026

Antifungal Stewardship: Time to Reappraise the Priorities toward Increasing Invasive Fungal Infections.

Annals of African medicine
2025

Insights into Aspergillus fumigatus morphogenesis and pathogenesis through the putative lipid transporter ArvA.

bioRxiv : the preprint server for biology
2025

High mortality and mechanical ventilation in COVID-19-associated pulmonary aspergillosis: insights from a two-center retrospective cohort study.

Frontiers in public health
2025

Pharmacovigilance insights: safety profiles of antifungal agents for invasive aspergillosis.

Frontiers in pharmacology
2025

A Rare Case of Allergic Bronchopulmonary Aspergillosis With Endobronchial Aspergilloma Causing Total Lung Collapse.

Cureus
2026

Fungal keratitis following laser assisted lenticule extraction surgery with use of losartan as an anti-scarring agent - a case report.

American journal of ophthalmology case reports
2026

Antifungal treatment strategies in intensive care unit patients.

European journal of clinical investigation
2026

Duplex droplet digital PCR (ddPCR) improves the diagnosis of Aspergillus and Fusarium keratitis.

Experimental eye research
2026

Infective Endocarditis Caused by Pan-Azole-Resistant Aspergillus fumigatus in a Lung Transplant Recipient.

Transplant infectious disease : an official journal of the Transplantation Society
2025

Fatal Breakthrough Invasive Fungal Infection due to Aspergillus flavus in a Pediatric Patient with Adenosine Deaminase Deficiency.

Infectious diseases &amp; clinical microbiology
2026

Aspergillus fumigatus brain abscess in an immunocompromised patient receiving a second-generation Bruton Tyrosine Kinase inhibitor (BTKi).

Diagnostic microbiology and infectious disease
2026

Deep learning on meta-analytic data for therapeutic decision-making in central nervous system aspergillosis.

BMC infectious diseases
2026

Analysis of Aspergillus spp. Isolates According to Temporal-Spatial, Sociodemographic, and Clinical Variables-Microsatellite Typing of Clinical and Environmental Samples of Aspergillus fumigatus in a University Hospital in Sao Paulo, Brazil.

Mycoses
2026

Pulmonary Fungal Infections in the Immunocompetent Host.

Chest
2026

An Unforeseen Diagnosis After Liver Transplantation for Acute Liver Failure: Extranodal NK/T-Cell Lymphoma.

Case reports in hepatology
2026

Skull base invasive aspergillosis in a peritoneal dialysis patient: A rare and devastating complication.

Medical mycology case reports
2026

Pathogen-specific IgE-reactive cytosolic allergenic epitopes of Aspergillus fumigatus for immunodiagnostic/immunotherapeutic applications against allergic aspergillosis.

Annals of clinical microbiology and antimicrobials
2026

Minimally invasive management of a centrally located pulmonary aspergilloma in an adolescent patient.

Multimedia manual of cardiothoracic surgery : MMCTS
2026

[How do I treat : allergic bronchopulmonary aspergillosis in patients with cystic fibrosis].

Revue medicale de Liege
2026

Clinical Features and Mortality of Chronic Pulmonary Aspergillosis in Brazil: a Multicenter Cohort Study.

Open forum infectious diseases
2026

Mucorales PCR Testing in Respiratory and Biopsy Samples From Immunocompromised Patients With Invasive Pulmonary Aspergillosis and Other Mold Infections: Results From a Multicenter ECMM Study.

Open forum infectious diseases
2026

Compassionate Use of Olorofim for Invasive Mold Infections: A Nationwide Observational Study in France.

Open forum infectious diseases
2026

Investigation of azole resistance in Aspergillus species isolated from clinical specimens by azole agar screening method.

Journal of medical microbiology
2026

Concurrent Administration of Triazoles with Chemotherapeutic and/or Immunosuppressant Agents Known to Have Moderate-to-Severe Drug-Drug Interactions in Patients with Hematologic Malignancies Hospitalized for Invasive Aspergillosis.

Mycopathologia
2026

Beyond Fumigatus: a molecular portrait of clinical Aspergillus diversity, pathogenicity, and antifungal resistance.

Antimicrobial agents and chemotherapy
2026

Clinical spectrum of ICU-acquired invasive pulmonary aspergillosis according to SARS-CoV2 infection: a multicenter prospective cohort study.

European journal of clinical microbiology &amp; infectious diseases : official publication of the European Society of Clinical Microbiology
2025

Pathogen spectrum and management strategies for opportunistic infections in lung cancer in the immunotherapy era: recent advances from fungi to mycobacteria.

American journal of cancer research
2025

Global population genomics redefines domestication and clinical diversity in the Aspergillus flavus-oryzae complex.

IMA fungus
2025

Allergic bronchopulmonary aspergillosis and Aspergillus-related airway diseases in bronchiectasis: a narrative review.

Journal of thoracic disease
2026

Fungal pericarditis due to Aspergillus fumigatus in a dog.

The Journal of small animal practice
2026

Invasive aspergillosis in a child without any identifiable risk factors.

Indian journal of medical microbiology
2025

Aspergillus sensitisation & allergic bronchopulmonary aspergillosis in chronic obstructive pulmonary disease: Redefining a treatable trait.

The Indian journal of medical research
2025

Invasive Pulmonary Aspergillosis in Non-Neutropenic Patients: An Evolving Clinical Paradigm.

Diagnostics (Basel, Switzerland)
2026

Optimizing diagnostic approaches for allergic bronchopulmonary aspergillosis: Comparative analysis of IgG/IgE ELISA and serum precipitins assays.

Allergy and asthma proceedings
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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Chest X-ray prior to biological treatment in inflammatory bowel diseases: it is not only about tuberculosis - a case report and literature review.
    European journal of gastroenterology &amp; hepatology· 2026· PMID 41870914mais citado
  2. Synergistic effects of S100 calcium-binding protein A12 combined with Pentraxin 3 in invasive pulmonary aspergillosis and their clinical application prospects.
    Frontiers in cellular and infection microbiology· 2026· PMID 41868148mais citado
  3. Unraveling the complexities: A comprehensive review of severe fever with thrombocytopenia syndrome and its associated complications.
    iScience· 2026· PMID 41858618mais citado
  4. Diagnosis, clinical features and survival analysis of invasive pulmonary aspergillosis among critically ill patients: a retrospective cohort study based on updated criteria.
    Frontiers in cellular and infection microbiology· 2026· PMID 41809990mais citado
  5. Amphotericin B promotes respiratory viral entry by enhancing late endosomal maturation and fusion via glucocerebrosidase-mediated ceramide remodeling.
    Nature communications· 2026· PMID 41803143mais citado
  6. Falcon plasma proteomics to improve avian aspergillosis diagnosis.
    J Proteomics· 2026· PMID 41990917recente
  7. Histopathological Diagnosis of Infectious Diseases: Experience From a Tertiary Care Center in a Sub-Saharan African Country.
    Int J Surg Pathol· 2026· PMID 41989331recente
  8. Editorial: Targeting major human fungal pathogens: novel insights into virulence and antifungal therapies.
    Front Cell Infect Microbiol· 2026· PMID 41987900recente
  9. Predicting Mortality in Intensive Care Unit Patients With Allergic Bronchopulmonary Aspergillosis (ABPA) Using an Interpretable Machine Learning Model: A Retrospective Cohort Study.
    Can Respir J· 2026· PMID 41986939recente
  10. Identification of Clinical Characteristics and Risk Factors of Invasive Pulmonary Aspergillosis in Patients with Acquired Immunodeficiency Syndrome: A Retrospective Study.
    Infect Drug Resist· 2026· PMID 41983108recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:1163(Orphanet)
  2. MONDO:0005657(MONDO)
  3. GARD:5856(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q259626(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Aspergilose
Compêndio · Raras BR

Aspergilose

ORPHA:1163 · MONDO:0005657
Prevalência
Unknown
Herança
Not applicable
CID-10
B44.0 · Aspergilose pulmonar invasiva
CID-11
Ensaios
27 ativos
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0004030
Repurposing
3 candidatos
caspofungin"bacterial cell wall synthesis inhibitor|fungal 1,3-beta-D-glucan synthase inhibitor"
itraconazolecytochrome P450 inhibitor
voriconazole
Wikidata
Wikipedia
Papers 10a
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