Raras
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Cutis marmorata telangiectásica congênita
ORPHA:1556CID-10 · Q82.8CID-11 · LC52OMIM 219250DOENÇA RARA

A Cutis Marmorata Telangiectática Congênita (CMTC) é uma alteração dos vasos sanguíneos presente desde o nascimento, que pode ser localizada (em uma parte do corpo) ou generalizada (espalhada por várias partes). Caracteriza-se por um padrão persistente de "pele marmorizada" – ou seja, a pele tem uma aparência manchada como mármore, com cores que vão do azulado ao roxo escuro. Há também vasinhos finos e avermelhados, parecidos com "teias de aranha", e veias mais dilatadas. Ocasionalmente, a pele afetada pode apresentar feridas e afinamento.

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Introdução

O que você precisa saber de cara

📋

A Cutis Marmorata Telangiectática Congênita (CMTC) é uma alteração dos vasos sanguíneos presente desde o nascimento, que pode ser localizada (em uma parte do corpo) ou generalizada (espalhada por várias partes). Caracteriza-se por um padrão persistente de "pele marmorizada" – ou seja, a pele tem uma aparência manchada como mármore, com cores que vão do azulado ao roxo escuro. Há também vasinhos finos e avermelhados, parecidos com "teias de aranha", e veias mais dilatadas. Ocasionalmente, a pele afetada pode apresentar feridas e afinamento.

Publicações científicas
264 artigos
Último publicado: 2026 Apr 10

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
<1 / 1 000 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Casos conhecidos
300
pacientes catalogados
Início
Neonatal
🏥
SUS: Cobertura mínimaScore: 35%
Centros em: SP, PR, SC, RS, ES +10CID-10: Q82.8
🇧🇷Dados SUS / DATASUS
PROCEDIMENTOS SIGTAP (5)
0202010503
Cariótipo — bandas G, Q ou Rgenetic_test
0202010600
Pesquisa de microdeleções/microduplicações por FISHlab_test
0202010694
Sequenciamento completo do exoma (WES)rehabilitation
0202010260
Dosagem de alfa-fetoproteína
0301070040
Atendimento em reabilitação — doenças raras
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🦴
Ossos e articulações
8 sintomas
🧬
Pele e cabelo
6 sintomas
📏
Crescimento
3 sintomas
👁️
Olhos
2 sintomas
🧠
Neurológico
2 sintomas
😀
Face
2 sintomas

+ 14 sintomas em outras categorias

Características mais comuns

90%prev.
Anormalidade da pele
Muito frequente (99-80%)
90%prev.
Anormalidade do membro inferior
Muito frequente (99-80%)
90%prev.
Convulsão
Muito frequente (99-80%)
90%prev.
Erosão cutânea
Muito frequente (99-80%)
90%prev.
Membros inferiores curtos
Muito frequente (99-80%)
90%prev.
Cutis marmorata
Muito frequente (99-80%)
38sintomas
Muito frequente (9)
Frequente (4)
Ocasional (19)
Sem dados (6)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 38 características clínicas mais associadas, ordenadas por frequência.

Anormalidade da peleAbnormality of the skin
Muito frequente (99-80%)90%
Anormalidade do membro inferiorAbnormality of the lower limb
Muito frequente (99-80%)90%
ConvulsãoSeizure
Muito frequente (99-80%)90%
Erosão cutâneaSkin erosion
Muito frequente (99-80%)90%
Membros inferiores curtosShort lower limbs
Muito frequente (99-80%)90%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico264PubMed
Últimos 10 anos102publicações
Pico202014 papers
Linha do tempo
2026Hoje · 2026📈 2020Ano de pico🧪 2022Primeiro ensaio clínico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

Genes associados

2 genes identificados com associação a esta condição. Padrão de herança: Not applicable.

ARL6IP6ADP-ribosylation factor-like protein 6-interacting protein 6Candidate gene tested inTolerante
LOCALIZAÇÃO

Nucleus inner membrane

OUTRAS DOENÇAS (1)
cutis marmorata telangiectatica congenita
HGNC:24048UniProt:Q8N6S5
GNA11Guanine nucleotide-binding protein subunit alpha-11Disease-causing somatic mutation(s) inAltamente restrito
FUNÇÃO

Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:31073061). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:31073061). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:31073061). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, t

LOCALIZAÇÃO

Cell membraneCytoplasm

VIAS BIOLÓGICAS (10)
PLC beta mediated eventsG-protein activationADP signalling through P2Y purinoceptor 1G alpha (q) signalling eventsThrombin signalling through proteinase activated receptors (PARs)
MECANISMO DE DOENÇA

Hypocalciuric hypercalcemia, familial 2

A form of hypocalciuric hypercalcemia, a disorder of mineral homeostasis that is transmitted as an autosomal dominant trait with a high degree of penetrance. It is characterized biochemically by lifelong elevation of serum calcium concentrations and is associated with inappropriately low urinary calcium excretion and a normal or mildly elevated circulating parathyroid hormone level. Hypermagnesemia is typically present. Affected individuals are usually asymptomatic and the disorder is considered benign. However, chondrocalcinosis and pancreatitis occur in some adults.

EXPRESSÃO TECIDUAL(Ubíquo)
Cerebelo
153.0 TPM
Cérebro - Hemisfério cerebelar
140.5 TPM
Testículo
104.7 TPM
Esôfago - Muscular
97.3 TPM
Fallopian Tube
94.3 TPM
OUTRAS DOENÇAS (8)
autosomal dominant hypocalcemia 2familial hypocalciuric hypercalcemia 2anastomosing haemangiomauveal melanoma
HGNC:4379UniProt:P29992

Variantes genéticas (ClinVar)

61 variantes patogênicas registradas no ClinVar.

🧬 GNA11: NM_002067.5(GNA11):c.548G>C (p.Arg183Pro) ()
🧬 GNA11: NM_002067.5(GNA11):c.535G>A (p.Val179Met) ()
🧬 GNA11: NM_002067.5(GNA11):c.980A>G (p.His327Arg) ()
🧬 GNA11: NM_002067.5(GNA11):c.548G>A (p.Arg183His) ()
🧬 GNA11: NM_002067.5(GNA11):c.542G>C (p.Arg181Pro) ()
Ver todas no ClinVar

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Cutis marmorata telangiectásica congênita

Centros de Referência SUS

24 centros habilitados pelo SUS para Cutis marmorata telangiectásica congênita

Centros para Cutis marmorata telangiectásica congênita

Detalhes dos centros

Hospital Universitário Prof. Edgard Santos (HUPES)

R. Dr. Augusto Viana, s/n - Canela, Salvador - BA, 40110-060 · CNES 0003808

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do Metabolismo

Hospital Infantil Albert Sabin

R. Tertuliano Sales, 544 - Vila União, Fortaleza - CE, 60410-794 · CNES 2407876

Serviço de Referência

Rota
Anomalias CongênitasDeficiência Intelectual

Hospital de Apoio de Brasília (HAB)

AENW 3 Lote A Setor Noroeste - Plano Piloto, Brasília - DF, 70684-831 · CNES 0010456

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital Estadual Infantil e Maternidade Alzir Bernardino Alves (HIABA)

Av. Min. Salgado Filho, 918 - Soteco, Vila Velha - ES, 29106-010 · CNES 6631207

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital das Clínicas da UFG

Rua 235 QD. 68 Lote Área, Nº 285, s/nº - Setor Leste Universitário, Goiânia - GO, 74605-050 · CNES 2338424

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do Metabolismo

Hospital Universitário da UFJF

R. Catulo Breviglieri, Bairro - s/n - Santa Catarina, Juiz de Fora - MG, 36036-110 · CNES 2297442

Atenção Especializada

Rota
Anomalias Congênitas

Hospital das Clínicas da UFMG

Av. Prof. Alfredo Balena, 110 - Santa Efigênia, Belo Horizonte - MG, 30130-100 · CNES 2280167

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital Universitário Julio Müller (HUJM)

R. Luis Philippe Pereira Leite, s/n - Alvorada, Cuiabá - MT, 78048-902 · CNES 2726092

Atenção Especializada

Rota
Anomalias Congênitas

Hospital Universitário João de Barros Barreto

R. dos Mundurucus, 4487 - Guamá, Belém - PA, 66073-000 · CNES 2337878

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital Universitário Lauro Wanderley (HULW)

R. Tabeliao Estanislau Eloy, 585 - Castelo Branco, João Pessoa - PB, 58050-585 · CNES 0002470

Atenção Especializada

Rota
Anomalias Congênitas

Instituto de Medicina Integral Prof. Fernando Figueira (IMIP)

R. dos Coelhos, 300 - Boa Vista, Recife - PE, 50070-902 · CNES 0000647

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital Pequeno Príncipe

R. Des. Motta, 1070 - Água Verde, Curitiba - PR, 80250-060 · CNES 3143805

Serviço de Referência

Rota
Anomalias CongênitasDeficiência Intelectual

Hospital Universitário Regional de Maringá (HUM)

Av. Mandacaru, 1590 - Parque das Laranjeiras, Maringá - PR, 87083-240 · CNES 2216108

Atenção Especializada

Rota
Anomalias Congênitas

Hospital de Clínicas da UFPR

R. Gen. Carneiro, 181 - Alto da Glória, Curitiba - PR, 80060-900 · CNES 2364980

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital Universitário Pedro Ernesto (HUPE-UERJ)

Blvd. 28 de Setembro, 77 - Vila Isabel, Rio de Janeiro - RJ, 20551-030 · CNES 2280221

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do Metabolismo

Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira (IFF/Fiocruz)

Av. Rui Barbosa, 716 - Flamengo, Rio de Janeiro - RJ, 22250-020 · CNES 2269988

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital São Lucas da PUCRS

Av. Ipiranga, 6690 - Jardim Botânico, Porto Alegre - RS, 90610-000 · CNES 2232928

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do Metabolismo

Hospital de Clínicas de Porto Alegre (HCPA)

Rua Ramiro Barcelos, 2350 Bloco A - Av. Protásio Alves, 211 - Bloco B e C - Santa Cecília, Porto Alegre - RS, 90035-903 · CNES 2237601

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital Universitário da UFSC (HU-UFSC)

R. Profa. Maria Flora Pausewang - Trindade, Florianópolis - SC, 88036-800 · CNES 2560356

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do Metabolismo

Hospital das Clínicas da FMUSP

R. Dr. Ovídio Pires de Campos, 225 - Cerqueira César, São Paulo - SP, 05403-010 · CNES 2077485

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital de Base de São José do Rio Preto

Av. Brg. Faria Lima, 5544 - Vila Sao Jose, São José do Rio Preto - SP, 15090-000 · CNES 2079798

Atenção Especializada

Rota
Anomalias Congênitas

Hospital de Clínicas da UNICAMP

R. Vital Brasil, 251 - Cidade Universitária, Campinas - SP, 13083-888 · CNES 2748223

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital de Clínicas de Ribeirão Preto (HCRP-USP)

R. Ten. Catão Roxo, 3900 - Vila Monte Alegre, Ribeirão Preto - SP, 14015-010 · CNES 2082187

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

UNIFESP / Hospital São Paulo

R. Napoleão de Barros, 715 - Vila Clementino, São Paulo - SP, 04024-002 · CNES 2688689

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do Metabolismo
Sobre os centros SUS: Estes centros são habilitados pelo Ministério da Saúde como Serviços de Referência em Doenças Raras ou Serviços de Atenção Especializada. O atendimento é pelo SUS, com encaminhamento da rede de atenção básica.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

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Publicações mais relevantes

Timeline de publicações
80 papers (10 anos)
#1

Clinical, Psychosocial, and Care Coordination Concerns in Macrocephaly Capillary Malformation Syndrome: Insights From a Large International Survey.

Pediatric blood &amp; cancer2026 Apr

Macrocephaly capillary malformation syndrome (M-CM or MCAP) is a rare overgrowth disorder characterized by primary megalencephaly, overgrowth, and a range of additional anomalies. This report presents findings from a survey of 101 caregivers or individuals with M-CM, collected by the M-CM Network. Respondents shared medical and psychosocial concerns across the age spectrum, with common issues including motor delays, speech deficits, hydrocephalus, and vascular abnormalities. The survey highlighted significant developmental and behavioral challenges for individuals. The report advocates for continued research focused on the comprehensive needs of patients with M-CM.

#2

Leg Length Discrepancy in Patients With Lower Extremity Cutis Marmorata Telangiectatica Congenita: A Multicenter Retrospective Study.

Pediatric dermatology2026 Feb 18

To assess the frequency of leg length discrepancy (LLD) in patients with lower extremity cutis marmorata telangiectatica congenita (CMTC), describe associated findings, and characterize LLD management. We conducted a retrospective chart review of patients diagnosed with lower extremity CMTC by dermatology and evaluated by orthopedics at Boston Children's Hospital and Children's Hospital of Philadelphia from 1997 to 2024. LLD was assessed by orthopedic examination and/or radiographic imaging. Major LLD was defined as ≥ 2 cm at any age, or between 1 and 2 cm in children 4 years old or younger. Mild LLD was defined as < 2 cm, except when ≥ 1 cm was present by age 4. Kaplan-Meier analysis estimated the probability of developing major LLD by age 15. Twenty-eight patients with lower extremity CMTC were included. LLD was identified in 12 of 28 patients (43%), including 8 confirmed radiographically and 4 diagnosed by clinical assessment alone. Two (7%) were classified as major and 10 (36%) as mild. Limb hypoplasia occurred in 18 of 28 patients (64%). Kaplan-Meier analysis estimated a 7.1% cumulative risk of major LLD by age 15. Three of 12 patients (25%) with LLD were prescribed shoe lifts. LLD is common among patients with lower extremity CMTC. Early orthopedic assessment may facilitate timely intervention.

#3

Getting a Leg Up on Assessment of Cutis Marmorata Telangiectatica Congenita and Leg Length Discrepancy.

Pediatric dermatology2026 Mar 12
#4

Case Report: A novel DLL4 variant in a neonate with Adams-Oliver syndrome.

Frontiers in pediatrics2025

Adams-Oliver syndrome is a rare congenital disorder with six subtypes that have been identified. Subtypes 1, 3, 5, and 6 have an autosomal dominant inheritance pattern, whereas subtypes 2 and 4 have an autosomal recessive inheritance pattern. The clinical phenotype of Adams-Oliver syndrome is heterogeneous and can be accompanied by abnormalities in other organs, especially the cardiovascular system, such as cutis marmorata telangiectatica congenita, pulmonary hypertension, vascular abnormalities in other organs, and congenital heart defects. Herein, we report a case of Adams-Oliver syndrome caused by a de novo variant in DLL4. The patient was a neonate with clinical manifestations of skin defects who was diagnosed with Adams-Oliver syndrome on the basis of genetic testing.

#5

PIK3CA-Related Overgrowth Spectrum: Exploring brain growth from fetus to infant.

Pediatric neurology2025 Feb

Megalencephaly-capillary malformation-polymicrogyria syndrome (MCAP) is a rare neurological disorder characterized by abnormal brain size, vascular malformations, and body overgrowth. MCAP is caused by somatic mosaicism of PIK3CA, a crucial gene in regulation of cell growth and survival, and is one of the disorders in the PIK3CA-related overgrowth spectrum. We present a unique clinical report of a male infant diagnosed with MCAP from prenatal stages to age 12 months. Prenatal imaging unveiled ventricular asymmetry, later confirmed postnatally as megalencephaly. Genetic analysis identified a PIK3CA mutation. The patient underwent early interventions, including ventriculoperitoneal shunt placement and posterior fossa decompression. Despite early interventions, the patient developed progressive macrocrania, hydrocephalus, and significant neurodevelopmental delay. Multidisciplinary management and continuous neuroimaging were crucial in addressing complications associated with the disorder. This case underscores the critical need for multidisciplinary care and continual neuroimaging surveillance to effectively navigate the progressive complications associated with PIK3CA-related overgrowth spectrum. The diagnostic hurdles and management challenges intrinsic to the disorder's natural course are elucidated. Although current treatments manage symptoms, emerging therapies hold promise for improving patient outcomes.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC205 artigos no totalmostrando 100

2026

Getting a Leg Up on Assessment of Cutis Marmorata Telangiectatica Congenita and Leg Length Discrepancy.

Pediatric dermatology
2026

Leg Length Discrepancy in Patients With Lower Extremity Cutis Marmorata Telangiectatica Congenita: A Multicenter Retrospective Study.

Pediatric dermatology
2026

Clinical, Psychosocial, and Care Coordination Concerns in Macrocephaly Capillary Malformation Syndrome: Insights From a Large International Survey.

Pediatric blood &amp; cancer
2025

Clinical presentation, risk factors, and comorbidities of cutis marmorata telangiectatica congenita: a systematic review.

Pediatric research
2025

Cutis Marmorata Telangiectatica Congenita: Case Series and Literature Review.

Diagnostics (Basel, Switzerland)
2025

Cutaneous Features of Adams-Oliver Syndrome: Diagnosis, Differentiation, and Management.

Pediatric dermatology
2025

An infant with cutis marmorata telangiectatica congenita born to a mother with systemic lupus erythematosus.

Pediatrics international : official journal of the Japan Pediatric Society
2025

Capillary malformations updates on aetiopathogenesis, diagnosis, and management.

Presse medicale (Paris, France : 1983)
2025

Isolated Cutis Marmorata Telangiectatica Congenita in a Full-Term Neonate: A Case Report.

Cureus
2025

Case Report: A novel DLL4 variant in a neonate with Adams-Oliver syndrome.

Frontiers in pediatrics
2025

[Glaucoma in cutis marmorata telangiectatica congenita syndrome].

Journal francais d'ophtalmologie
2025

PIK3CA-Related Overgrowth Spectrum: Exploring brain growth from fetus to infant.

Pediatric neurology
2024

Defining the transcriptome of PIK3CA-altered cells in a human capillary malformation using single cell long-read sequencing.

Scientific reports
2024

A Rare Case of Vascular Malformation in India: Cutis Marmorata Telangiectatica Congenita.

Cureus
2024

Adams-Oliver syndrome associated with refractory glaucoma.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
2024

Generalized cutis marmorata telangiectatica congenita or neonatal lupus? A case report and literature review.

Clinical case reports
2024

Retinal abnormalities in a patient with cutis marmorata telangiectatica congenita.

BMJ case reports
2024

Optical coherence tomography angiography in pediatric ocular cutis marmorata telangiectatica congenita: A case series.

American journal of ophthalmology case reports
2024

Newborn with cutis marmorata telangiectatica congenita.

Anales de pediatria
2024

Optimization by mixture design of chitosan/multi-phase calcium phosphate/BMP-2 biomimetic scaffolds for bone tissue engineering.

Journal of the mechanical behavior of biomedical materials
2024

Infrequent associations of cutis marmorata telangiectatica congenita: a two-case report.

Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica
2023

An expanded clinical spectrum of hypoinsulinaemic hypoketotic hypoglycaemia.

Orphanet journal of rare diseases
2024

Molecular characterization of 13 patients with PIK3CA-related overgrowth spectrum using a targeted deep sequencing approach.

American journal of medical genetics. Part A
2024

Persistent Cutis Marmorata Telangiectatica Congenita Associated with Isolated Hemihypertrophy and Edema Attacks.

Clinical pediatrics
2023

Cutis marmorata telangiectatica congenita: Incidence of extracutaneous manifestations and a proposed clinical definition.

Pediatric dermatology
2023

Segmental vasoconstricted patches with a border of telangiectasia.

Pediatric dermatology
2023

Persistent Generalized Cutis Marmorata Telangiectatica Congenita with Venectasia.

Indian dermatology online journal
2023

Diffuse Capillary Malformation With Overgrowth (DCMO): A Case Report and Literature Review.

Cureus
2023

Cutis marmorata telangiectatica congenita in a newborn: A differential diagnosis.

Pediatrics and neonatology
2023

Case report: A preterm infant with rubinstein-taybi syndrome and Marmorata telangiectatica harboring a frameshift mutation in the CREBBP gene.

Frontiers in pediatrics
2023

[Update on nevi and nevoid skin disorders].

Dermatologie (Heidelberg, Germany)
2023

Mosaic pathogenic variants in AKT3 cause capillary malformation and undergrowth.

American journal of medical genetics. Part A
2022

Prenatal diagnosis and delivery of megalencephaly-capillary malformation syndrome.

BMJ case reports
2023

Surgical management of Chiari malformation type 1 associated to MCAP syndrome and study of cerebellar and adjacent tissues for PIK3CA mosaicism.

European journal of medical genetics
2022

Ocular Melanocytosis and Peripheral Retinal Avascularity in a Case of Cutis Marmorata Telangiectatica Congenita.

Ophthalmic surgery, lasers &amp; imaging retina
2022

Ischemic Proliferative Retinopathy in a Korean Patient with Cutis Marmorata Telangiectatica Congenita: A Case Report.

Korean journal of ophthalmology : KJO
2022

Brain Abnormalities in PIK3CA-Related Overgrowth Spectrum: Physician, Patient, and Caregiver Experiences.

Advances in therapy
2023

Case Report: 2-Year-old With Wilms Tumors, Familial Heterozygous DIS3L2 Mutation, and Cutis Marmorata Telangiectatica Congenita.

Journal of pediatric hematology/oncology
2022

The utility of cerebrospinal fluid-derived cell-free DNA in molecular diagnostics for the PIK3CA-related megalencephaly-capillary malformation (MCAP) syndrome: a case report.

Cold Spring Harbor molecular case studies
2022

Cutis marmorata telangiectatica congenita being caused by postzygotic GNA11 mutations.

European journal of medical genetics
2022

Phenotypic and molecular characterization of five patients with PIK3CA-related overgrowth spectrum (PROS).

American journal of medical genetics. Part A
2022

Cutis marmorata telangiectatica congenita with isolated lower limb defect and angiokeratoma.

Birth defects research
2020

Born in the Purple: An Exceptional Case of Cutis Marmorata Telangiectatica Congenita.

Acta dermatovenerologica Croatica : ADC
2020

Cutis marmorata telangiectatica congenita successfully treated with intense pulsed light and pulse dyed laser therapy: a case report.

Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology
2021

Clinical and neuroimaging findings in 33 patients with MCAP syndrome: A survey to evaluate relevant endpoints for future clinical trials.

Clinical genetics
2020

Cutis Marmorata Telangiectatica Congenita in Identical Triplets.

Skinmed
2021

Aplasia cutis congenita in a CDC42-related developmental phenotype.

American journal of medical genetics. Part A
2020

Cutis Marmorata Telangiectatica Congenita Associated with Hemiatrophy.

Case reports in pediatrics
2020

Cutis marmorata telangiectasia congenita with painful ulcerations.

Dermatology online journal
2020

Early cutis marmorata telangiectatica congenita masquerading as ulcerated retiform purpura: a diagnostic trap.

Pediatric dermatology
2021

Cutis marmorata telangiectatica congenita.

Archives of disease in childhood. Fetal and neonatal edition
2020

Adams-Oliver syndrome: a case of bilateral progressive ischemic maculopathy.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
2020

Ophthalmologic alterations in cutis marmorata telangiectatica congenita: a series of cases.

Arquivos brasileiros de oftalmologia
2020

Clinical overlap between CLAPO syndrome and macrocephaly-capillary malformation syndrome.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
2020

Cutis marmorata telangiectatica congenita: a focus on its diagnosis, ophthalmic anomalies, and possible etiologic factors.

Ophthalmic genetics
2020

A Plum-Colored Reticular Birthmark in a Neonate.

The Journal of pediatrics
2020

[Polymorphism and differential diagnosis of neonatal lupus erythematosus].

Annales de dermatologie et de venereologie
2020

Cutis marmorata telangiectatica congenita-like lesion with fibrotic appearance.

Pediatric dermatology
2019

Cutis marmorata telangiectatica congenita: a literature review.

Orphanet journal of rare diseases
2019

New case of phacomatosis cesio-flammeo-marmorata: the time is right to review the classification for phacomatosis pigmentovascularis.

International journal of dermatology
2019

A rare vascular lesion of newborn: cutis marmorata telangiectatica congenital.

Turk pediatri arsivi
2019

Image Gallery: Atrophic cutis marmorata telangiectatica congenita.

The British journal of dermatology
2019

Phakomatosis Pigmentovascularis: A Clinical Profile of 11 Indian Patients.

Indian journal of dermatology
2019

Ocular Manifestations of Cutis Marmorata Telangiectatica Congenita.

Ophthalmology. Retina
2019

[Syndromes with vascular skin anomalies].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
2019

[Adams-Oliver syndrome and cutis marmorata telangiectatica congenita].

Annales de dermatologie et de venereologie
2018

Cutis marmorata telangiectatica congenita with skin ulceration: a rare benign skin vascular malformation.

BMJ case reports
2019

Cutis Marmorata Telangiectatica Congenita Presenting as a Fetal Hemothorax.

Fetal diagnosis and therapy
2021

RETINAL NEOVASCULARIZATION FROM A PATIENT WITH CUTIS MARMORATA TELANGIECTATICA CONGENITA.

Retinal cases &amp; brief reports
2020

Cutis marmorata telangiectatica congenita: a diagnostic challenge.

Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia
2018

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA)-related overgrowth spectrum: A brief report.

Pediatric dermatology
2018

Van Lohuizen Syndrome - A Case Report with a Diagnostic Delay of Four Years.

Open access Macedonian journal of medical sciences
2018

Reticular rash in a neonate.

Journal of paediatrics and child health
2018

Cutis marmorata telangiectatica congenita and major lower limb asymmetry.

BMJ case reports
2018

Outcomes of Infantile-Onset Glaucoma Associated With Port Wine Birthmarks and Other Periocular Cutaneous Vascular Malformation.

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)
2017

Concurrent Sturge-Weber syndrome, facial infantile hemangioma, and cutis marmorata telangiectatica congenita.

Cutis
2018

Cutis mormorata telangiectatica congenital successfully treated with intense pulsed light therapy: A case report.

Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology
2017

Wilms tumor screening in diffuse capillary malformation with overgrowth and macrocephaly-capillary malformation: A retrospective study.

Journal of the American Academy of Dermatology
2017

Phacomatosis Cesioflammea with Cutis Marmorata-like Lesions and Unusual Extracutaneous Abnormalities: Is It a Distinct disorder?

Indian journal of dermatology
2016

Megalencephaly-capillary malformation-polymicrogyria syndrome: the first case report in Korea.

Korean journal of pediatrics
2018

RETINAL FINDINGS IN A CASE OF PRESUMED CUTIS MARMORATA TELANGIECTATICA CONGENITA.

Retinal cases &amp; brief reports
2016

Cutis Marmorata Telangiectatica Congenita: Clinical Features in 7 Cases.

Journal of the Medical Association of Thailand = Chotmaihet thangphaet
2016

Vascular Stains: Proposal for a Clinical Classification to Improve Diagnosis and Management.

Pediatric dermatology
2017

Megalencephaly-capillary malformation polymicrogyria: A review and complex pediatric case report.

Applied neuropsychology. Child
2016

Congenital cutis marmorata telangiectatica and syndactyly in a preterm: case report.

Archivos argentinos de pediatria
2016

Cutis marmorata telangiectatica congenita and aberrant Mongolian spots: Type V phacomatosis pigmentovascularis or phacomatosis cesiomarmorata.

JAAD case reports
2016

Severe holocord syrinx in a child with megalencephaly-capillary malformation syndrome.

Journal of neurosurgery. Pediatrics
2016

A case of phakomatosis pigmentovascularis type II: port-wine stain and dermal melanocytosis with cutis marmorata telangiectatica congenita-like lesions.

European journal of dermatology : EJD
2016

[Cutis marmorata telangiectatica congenita: Mutations in a susceptibility gene involved in cerebrovascular accidents].

Annales de dermatologie et de venereologie
2015

A CASE OF MACROCEPHALY-CAPILLARY MALFORMATION SYNDROME PRESENTING WITH HOT WATER EPILEPSY.

Genetic counseling (Geneva, Switzerland)
2015

Phacomatosis cesiomarmorata with hypospadias and phacomatosis cesioflammea with Sturge-Weber syndrome, Klippel-Trenaunay syndrome and aplasia of veins -- case reports with rare associations.

Dermatology online journal
2015

Management of Vascular Anomalies and Related Conditions Using Suction-Assisted Tissue Removal.

Plastic and reconstructive surgery
2016

Detection of a mosaic PIK3CA mutation in dental DNA from a child with megalencephaly capillary malformation syndrome.

Clinical dysmorphology
2015

The case of a boy with nevus of Ota, extensive Mongolian spot, nevus flammeus, nevus anemicus and cutis marmorata telangiectatica congenita: a unique instance of phacomatosis pigmentovascularis.

Anais brasileiros de dermatologia
2015

Red-white and blue baby: a case of phacomatosis pigmentovascularis type V.

Dermatology online journal
2015

Unusual case of phakomatosis pigmentovascularis in a Japanese female infant associated with three phakomatoses: Port-wine stain, dermal melanocytosis and cutis marmorata telangiectatica congenita.

The Journal of dermatology
2015

ARL6IP6, a susceptibility locus for ischemic stroke, is mutated in a patient with syndromic Cutis Marmorata Telangiectatica Congenita.

Human genetics
2015

Capillary malformations: a classification using specific names for specific skin disorders.

Journal of the European Academy of Dermatology and Venereology : JEADV
2014

[Cutis marmorata telangiectatica congenita revealing neonatal lupus].

The Pan African medical journal
2014

Cutis marmorata telangiectatica congenita in a preterm female newborn: case report and review of the literature.

La Pediatria medica e chirurgica : Medical and surgical pediatrics
Ver todos os 205 no EuropePMC

Associações

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Comunidades

Grupos ativos de quem convive com esta doença aqui no Raras

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Clinical, Psychosocial, and Care Coordination Concerns in Macrocephaly Capillary Malformation Syndrome: Insights From a Large International Survey.
    Pediatric blood &amp; cancer· 2026· PMID 41579065mais citado
  2. Leg Length Discrepancy in Patients With Lower Extremity Cutis Marmorata Telangiectatica Congenita: A Multicenter Retrospective Study.
    Pediatric dermatology· 2026· PMID 41705466mais citado
  3. Getting a Leg Up on Assessment of Cutis Marmorata Telangiectatica Congenita and Leg Length Discrepancy.
    Pediatric dermatology· 2026· PMID 41814925mais citado
  4. Case Report: A novel DLL4 variant in a neonate with Adams-Oliver syndrome.
    Frontiers in pediatrics· 2025· PMID 40098638mais citado
  5. PIK3CA-Related Overgrowth Spectrum: Exploring brain growth from fetus to infant.
    Pediatric neurology· 2025· PMID 39631263mais citado
  6. Cutis marmorata telangiectatica congenita.
    Br J Dermatol· 2026· PMID 41967098recente
  7. Clinical presentation, risk factors, and comorbidities of cutis marmorata telangiectatica congenita: a systematic review.
    Pediatr Res· 2025· PMID 41366050recente
  8. Cutis Marmorata Telangiectatica Congenita: Case Series and Literature Review.
    Diagnostics (Basel)· 2025· PMID 40870895recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:1556(Orphanet)
  2. OMIM OMIM:219250(OMIM)
  3. MONDO:0009055(MONDO)
  4. GARD:6228(GARD (NIH))
  5. Variantes catalogadas(ClinVar)
  6. Busca completa no PubMed(PubMed)
  7. Q1997180(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Cutis marmorata telangiectásica congênita
Compêndio · Raras BR

Cutis marmorata telangiectásica congênita

ORPHA:1556 · MONDO:0009055
Prevalência
<1 / 1 000 000
Casos
300 casos conhecidos
Herança
Not applicable
CID-10
Q82.8 · Outras malformações congênitas especificadas da pele
CID-11
Início
Neonatal
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0345419
EuropePMC
Wikidata
Papers 10a
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