A Encefalite por Herpes Simples (EHS) é uma inflamação grave do cérebro causada pelo vírus do Herpes Simples (HSV), que pode ter um desenvolvimento muito sério e ser fatal, principalmente se o tratamento for atrasado ou não for feito. O vírus do Herpes Simples (HSV) geralmente afeta as partes da frente e das laterais do cérebro, normalmente de forma desigual (um lado mais que o outro). Isso pode causar mudanças de personalidade, problemas de memória e raciocínio, dificuldade para falar ou entender o que os outros dizem, convulsões e fraqueza em alguma parte específica do corpo.
Introdução
O que você precisa saber de cara
A Encefalite por Herpes Simples (EHS) é uma inflamação grave do cérebro causada pelo vírus do Herpes Simples (HSV), que pode ter um desenvolvimento muito sério e ser fatal, principalmente se o tratamento for atrasado ou não for feito. O vírus do Herpes Simples (HSV) geralmente afeta as partes da frente e das laterais do cérebro, normalmente de forma desigual (um lado mais que o outro). Isso pode causar mudanças de personalidade, problemas de memória e raciocínio, dificuldade para falar ou entender o que os outros dizem, convulsões e fraqueza em alguma parte específica do corpo.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 17 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 30 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
5 genes identificados com associação a esta condição. Padrão de herança: Multigenic/multifactorial, Not applicable.
Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303, PubMed:28747347, PubMed:35215908). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12471095, PubMed:12539043, PubMed:14739303). Distinct protein-interaction motifs allow recruitment of the effector
Cytoplasmic vesicle, autophagosomeCytoplasm, cytosolMitochondrion
Encephalopathy, acute, infection-induced, 6, herpes-specific
A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.
Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal
Endoplasmic reticulum membraneEndosomeLysosomeCytoplasmic vesicle, phagosome
Encephalopathy, acute, infection-induced, 1, herpes-specific
A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 a
Cytoplasm
Glaucoma 1, open angle, P
A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. GLC1P is characterized by early onset, thin central corneas and low intraocular pressure.
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response
Endoplasmic reticulum membraneEndosome membraneEarly endosome
Immunodeficiency 83, susceptibility to viral infections
An immunologic disorder characterized by increased susceptibility to severe viral infections, including herpes simplex virus (HSV), varicella zoster virus (VZV), influenza A virus (IAV), hantavirus, and possibly respiratory syncytial virus (RSV). IMD83 clinical manifestations include acute infection-induced encephalitis and pneumonitis. The susceptibility to encephalitis or pneumonitis appears to result from impaired TLR3-dependent interferon production by nonhematopoietic cells that reside within the central nervous system or lung epithelial cells. IMD83 transmission pattern is consistent with autosomal dominant or autosomal recessive inheritance with incomplete penetrance.
Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types (PubMed:33148796, PubMed:33608556). In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activa
CytoplasmEndosomeMitochondrion
Immunodeficiency 132A
An autosomal dominant immunologic disorder characterized by increased susceptibility to infection with certain pathogens, including Herpes simplex virus and Mycobacterium abscessus. Immunologic work-up shows impaired production of cytokines, including INFB and IL6.
Medicamentos aprovados (FDA)
1 medicamento encontrado nos registros da FDA americana.
Variantes genéticas (ClinVar)
329 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
39 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Encefalite por vírus herpes simplex
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
Pesquisa e ensaios clínicos
5 ensaios clínicos encontrados.
Publicações mais relevantes
Severe herpes simplex virus encephalitis complicated by atypical Takotsubo cardiomyopathy with left ventricular systolic dysfunction.
A previously healthy woman in her 30s presented with high-grade fever, photophobia and fluctuating consciousness, and was diagnosed with herpes simplex virus type 1\ encephalitis. Her condition deteriorated, requiring intensive care support for type 1 respiratory failure. During her intensive care unit stay, she was found to have significant left ventricular systolic dysfunction with basal-mid akinesia and apical sparing on echocardiography. Cardiac MRI demonstrated features consistent with stress-induced (Takotsubo) cardiomyopathy. She made a complete neurological and cardiac recovery with supportive care, antiviral therapy and temporary heart-failure therapy. This case highlights the importance of considering cardiac involvement in severe encephalitis and the multidisciplinary management required for rare neuro-cardiac interactions.
Safety and efficacy of adjunct dexamethasone in adults with herpes simplex virus encephalitis in the UK (DexEnceph): a multicentre, observer-blind, randomised, phase 3, controlled trial.
Herpes simplex virus (HSV) encephalitis is characterised by inflammation and swelling of the brain, resulting in death or severe neurocognitive sequelae. HSV encephalitis is treated with the antiviral aciclovir but still has substantial mortality and morbidity. Adjunct corticosteroids are sometimes used, but whether they improve the outcome is unclear. We aimed to establish the safety and efficacy of adjunct corticosteroids in HSV encephalitis. In this multicentre, observer-blind, randomised, phase 3 trial, adults with HSV encephalitis admitted to 53 hospitals in the UK were randomly assigned to receive intravenous dexamethasone (10 mg/kg, four times daily for 4 days) plus intravenous aciclovir (10 mg/kg three times daily for at least 14 days; dexamethasone group), or intravenous aciclovir alone (control group). Eligible patients aged 16 years or older had suspected encephalitis (a febrile illness with new onset seizure, new focal neurological signs or alteration in consciousness, cognition, personality, or behaviour), with positive HSV type 1 or type 2 PCR test in CSF. Participants were randomly assigned by the trial team at the recruiting site, using a secure web-based randomisation programme. The primary outcome was verbal memory score at 26 weeks, measured by the Wechsler Memory Scale (WMS)-IV auditory memory index. Analyses of primary and secondary outcomes were performed according to the modified intention-to-treat principle, and safety analyses were based on whether participants received at least one dose of the study drug. Trial neuropsychologists assessing the primary outcome, and statisticians involved in the study's primary outcome, were masked to treatment group allocation. The trial is registered with the International Standard Randomised Controlled Trial Number Registry, ISRCTN11774734, and EudraCT, EudraCT2016-004835-19, and is completed. Between Sept 22, 2016, and Feb 2, 2022, 94 patients with HSV encephalitis were recruited, 47 (20 [43%] female and 27 [57%] male) to the dexamethasone group, and 47 (24 [51%] female and 23 [49%] male) to the control group. Dexamethasone was initiated a median 7 (IQR 4-8) days after hospital admission. Seven patients withdrew consent, and six were lost to follow-up. Thus, 81 were included in the modified intention-to-treat analysis (39 in the treatment group and 42 in the control group). The primary outcome, verbal memory score at 26 weeks, did not differ significantly between the groups (71 [SD 26] in the dexamethasone group, and 69 [SD 25] in the control group; adjusted difference 1·77 [95% CI -9·57 to 13·12; p=0·76). There were 27 adverse events involving 18 (38%) participants in the control group, and 25 adverse events involving 18 (40%) participants in the dexamethasone group. The most common serious adverse events were seizures requiring readmission to hospital (affecting one [2%] patient in the dexamethasone group and one [2%] patient in the control group) and thrombotic events, including deep vein thrombosis (affecting one [2%] patient in the dexamethasone group) and pulmonary embolism (affecting one [2%]patient in the dexamethasone group). There were no treatment-related deaths. In adults with HSV encephalitis, dexamethasone plus aciclovir had a satisfactory safety profile but did not improve verbal memory score compared with aciclovir alone. Given the established role of corticosteroids in other inflammatory encephalitides, our findings suggest that their early use in suspected encephalitis is unlikely to be harmful. Future studies should assess more targeted immunomodulatory approaches in HSV encephalitis. National Institute for Health and Care Research.
Effect of different doses of dexamethasone on the penetration of acyclovir across the blood-brain barrier.
Acyclovir (ACV) is a widely used antiviral agent for the treatment of herpes simplex virus encephalitis. Dexamethasone (DEX) is often co-administered as an adjunctive therapy. Tariquidar (TQD), a potent and selective inhibitor of P-glycoprotein, has been demonstrated to enhance the brain accumulation of ACV. This study is designed to systematically investigate the impact of varying DEX dosages on the blood-brain barrier (BBB) transport of ACV, elucidate the mechanisms involved, and evaluate the therapeutic potential of TQD in the management of herpes simplex virus encephalitis. Microdialysis, coupled with high-performance liquid chromatography, was employed to measure unbound ACV concentrations in blood and brain tissue at pre-determined time intervals. The effects of low (0.5 mg/kg), moderate (1 mg/kg), and high (3 mg/kg) doses of DEX, administered continuously for 4 days, on the pharmacokinetic parameters of ACV were evaluated in the presence and absence of tariquidar (TQD, P-glycoprotein inhibitor, 8 mg/kg). The BBB transport of ACV was assessed by calculating the ratio of the area under the unbound brain drug concentration-time curve to the area under the unbound blood drug concentration over time, to reflect changes in the BBB transport (Kp,uu,brain) of ACV. The mean of the area under the unbound brain and blood drug concentration-time curve, and Kp,uu,brain in rats of the solvent control (SC) group were 2674 ± 448 min·μg/mL, 564 ± 136 min·μg/mL, and 20.9 %, respectively. In the low-dose DEX group, the Kp,uu,brain of ACV was 19.5 %, with no statistically significant difference compared with the SC group (P > 0.05). In the moderate- and high-dose DEX groups, the Kp,uu,brain of ACV decreased to 17.0 % and 14.0 %, respectively, with a statistically significant difference compared with the SC group (P < 0.001). Pairwise comparisons further revealed significant differences in the Kp,uu,brain of ACV among different DEX dose groups. Conversely, TQD administration increased the Kp,uu,brain of ACV by 1.40-fold (P < 0.001). The Kp,uu,brain in the TQD plus low-dose DEX group was 27.1 %, significantly higher than that of the SC group (P < 0.001). The Kp,uu,brain of the TQD plus moderate-dose DEX and TQD plus high-dose DEX groups was 21.6 % and 18.4 %, respectively, with no significant difference compared to the SC group (P > 0.05). Low-dose DEX does not significantly alter the BBB transport of ACV. However, moderate to high doses of DEX exhibit a dose-dependent reduction in ACV penetration across the BBB. Co-administration of TQD with DEX counteracts this effect, and even enhancing the BBB transport of ACV.
Dexamethasone in herpes simplex virus encephalitis: timely insights amid study limitations.
Herpes Simplex Virus Encephalitis With Cerebellar Infarction and Cortical Laminar Necrosis.
Herpes simplex virus (HSV) encephalitis typically involves the temporal lobes, and cerebellar involvement with stroke and cortical laminar necrosis (CLN) is rare. A 40-year-old man with no prior comorbidities presented with 10 days of positional vertigo, vomiting and intermittent fever. Initial otorhinolaryngology assessment showed bilateral nystagmus and a positive fistula test, and he was treated as having a peripheral vestibular disorder. He re-presented with persistent vertigo and new confusion; on admission, he was febrile, hypertensive and ataxic, and within 24 hours, he developed worsening encephalopathy, focal deficits and generalised tonic-clonic seizures. Cerebrospinal fluid (CSF) analysis demonstrated lymphocytic pleocytosis, elevated protein, normal glucose, raised opening pressure and red blood cells, and polymerase chain reaction (PCR) for HSV DNA was positive, confirming HSV encephalitis. Brain magnetic resonance imaging (MRI) revealed an acute infarction in the right greater than the left cerebellar hemisphere with corresponding diffusion restriction on diffusion-weighted and apparent diffusion coefficient sequences. Follow-up imaging in the subacute phase showed curvilinear T1 hyperintensities along the cerebellar cortical ribbon consistent with CLN. The patient was treated with intravenous acyclovir, high-dose corticosteroids, antiepileptic drugs, osmotherapy, blood pressure control and supportive care. Over a three-week admission, his sensorium normalised, and seizures ceased, but truncal and appendicular ataxia persisted. At early outpatient review, he was ambulant with a cane, with mild residual truncal ataxia and no further seizures. This case highlights that HSV encephalitis can present with an acute vestibulocerebellar syndrome and be complicated by cerebellar infarction and CLN and emphasises the need for early neuroimaging and lumbar puncture in febrile patients with 'peripheral' vertigo.
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Herpes Simplex Virus Encephalitis With Cerebellar Infarction and Cortical Laminar Necrosis.
Severe herpes simplex virus encephalitis complicated by atypical Takotsubo cardiomyopathy with left ventricular systolic dysfunction.
Voxel-based morphometry and functional connectivity changes are associated with cognitive function in herpes simplex virus encephalitis.
📚 EuropePMC362 artigos no totalmostrando 199
Herpes Simplex Virus Encephalitis With Cerebellar Infarction and Cortical Laminar Necrosis.
CureusSevere herpes simplex virus encephalitis complicated by atypical Takotsubo cardiomyopathy with left ventricular systolic dysfunction.
BMJ case reportsVoxel-based morphometry and functional connectivity changes are associated with cognitive function in herpes simplex virus encephalitis.
Frontiers in neuroscienceSafety and efficacy of adjunct dexamethasone in adults with herpes simplex virus encephalitis in the UK (DexEnceph): a multicentre, observer-blind, randomised, phase 3, controlled trial.
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Phytomedicine : international journal of phytotherapy and phytopharmacologyThe Worldwide Prevalence of Herpes Simplex Virus Encephalitis and Meningitis: A Systematic Review and Meta-Analysis.
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Frontiers in immunologyHerpes Simplex Virus Encephalitis: An Unexpected Outcome in a Polytrauma Patient.
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Frontiers in neurologyHerpes simplex virus encephalitis in atopic dermatitis patients and responses to dupilumab: A real association or a chance occurrence?
Pediatric dermatology[Protective effect of Forsythiae Fructus extract on mice with herpes simplex encephalitis].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medicaHerpes Simplex Virus 1 Induces Microglia Gasdermin D-Dependent Pyroptosis Through Activating the NLR Family Pyrin Domain Containing 3 Inflammasome.
Frontiers in microbiologyA rare presentation of herpes simplex virus encephalitis occurring in a pediatric patient on dupilumab for atopic dermatitis.
Pediatric dermatologyPost-COVID-19 HSV encephalitis: a review.
QJM : monthly journal of the Association of PhysiciansHerpes Simplex Virus Encephalitis With Initial Negative Polymerase Chain Reaction in the Cerebrospinal Fluid: Prevalence, Associated Factors, and Clinical Impact.
Critical care medicineStress Cardiomyopathy Triggered by Status Epilepticus Secondary to Herpes Simplex Virus Encephalitis: Case Report and Literature Review.
CureusClinical Characteristics and Follow-Up of Seizures in Children With Anti-NMDAR Encephalitis.
Frontiers in neurologyLife-Threatening Enterovirus 71 Encephalitis in Unrelated Children with Autosomal Dominant TLR3 Deficiency.
Journal of clinical immunologyVaricella-zoster virus encephalitis resembling herpes simplex virus encephalitis.
BMJ case reportsEpileptic negative myoclonus in herpes simplex virus encephalitis.
Epileptic disorders : international epilepsy journal with videotapeQuercus acuta Thunb. (Fagaceae) and Its Component, Isoquercitrin, Inhibit HSV-1 Replication by Suppressing Virus-Induced ROS Production and NF-κB Activation.
Antioxidants (Basel, Switzerland)Human viral encephalitis associated with suid herpesvirus 1.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyThe use of antiviral drugs in children.
Journal of chemotherapy (Florence, Italy)Herpes Simplex Virus-2 Encephalitis Complicated with Multiple Cranial Neuritis and Dysautonomia.
Journal of pediatric neurosciencesNon-convulsive status epilepticus as an initial manifestation of herpes simplex virus encephalitis.
Epileptic disorders : international epilepsy journal with videotapeA novel bioluminescent herpes simplex virus 1 for in vivo monitoring of herpes simplex encephalitis.
Scientific reportsAtypical imaging presentation of herpes simplex virus encephalitis in paediatric immunocompromised oncology patients.
Journal of medical imaging and radiation oncologyDeep Learning-Enabled Identification of Autoimmune Encephalitis on 3D Multi-Sequence MRI.
Journal of magnetic resonance imaging : JMRIAnti-inflammatory effects of kaempferol-3-O-rhamnoside on HSV-1 encephalitis in vivo and in vitro.
Neuroscience lettersLong-term sequelae of herpes simplex virus encephalitis-related white matter injury: correlation of neuropsychological outcome and diffusion tensor imaging.
Journal of neurovirologyAnti-NMDAR Encephalitis After Neonatal HSV-1 Infection in a Child With Low TLR-3 Function.
PediatricsAnalysing triggers for anti-NMDA-receptor encephalitis including herpes simplex virus encephalitis and ovarian teratoma: results from the Queensland Autoimmune Encephalitis cohort.
Internal medicine journalAntibody-Mediated Autoimmune Diseases of the CNS: Challenges and Approaches to Diagnosis and Management.
Frontiers in neurologyProtocol for DexEnceph: a randomised controlled trial of dexamethasone therapy in adults with herpes simplex virus encephalitis.
BMJ openUS Hospitalizations and 60-Day Readmission Rates Associated With Herpes Simplex Virus Encephalitis: Analysis of All Cause Readmissions and Encephalopathy Associated Readmissions.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaPediatric Autoimmune Encephalitis and Its Relationship With Infection.
Pediatric neurologyAnti-N-Methyl-D-Aspartate receptor Encephalitis as a potential cause of worsening Herpes Simplex Virus Encephalitis.
JPMA. The Journal of the Pakistan Medical AssociationUntreated herpes simplex virus encephalitis without a fatal outcome.
Journal of neurovirologyASC-dependent inflammasomes contribute to immunopathology and mortality in herpes simplex encephalitis.
PLoS pathogensChild Neurology: Intractable Epilepsy and Transient Deficits in a Patient With a History of Herpes Simplex Virus Encephalitis.
NeurologyFever with no elevation in inflammatory markers: herpes simplex virus encephalitis.
QJM : monthly journal of the Association of PhysiciansAn adolescent with herpes simplex encephalitis, presenting with mild symptoms and rapid deterioration: A case report.
SAGE open medical case reportsEpilepsy after brain infection in adults: A register-based population-wide study.
NeurologyAn Early Microglial Response Is Needed To Efficiently Control Herpes Simplex Virus Encephalitis.
Journal of virologyManagement and results of epilepsy surgery associated with acyclovir prophylaxis in four pediatric patients with drug-resistant epilepsy due to herpetic encephalitis and review of the literature.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology SocietyFeasibility of Continuous Infusions of Acyclovir.
The Pediatric infectious disease journalHerpes simplex virus encephalitis after temporal lobe resection: an infrequent but treatable complication of epilepsy surgery.
European journal of neurologyLong-Term Survival, Morbidity, Social Functioning and Risk of Disability in Patients with a Herpes Simplex Virus Type 1 or Type 2 Central Nervous System Infection, Denmark, 2000-2016.
Clinical epidemiologyPathophysiology of paraneoplastic and autoimmune encephalitis: genes, infections, and checkpoint inhibitors.
Therapeutic advances in neurological disordersIntraventricular hemorrhage as clinical presentation of herpes simplex virus encephalitis. A case report and review of the literature.
The International journal of neuroscience[A case of herpes simplex virus encephalitis recurring after a seven-year interval].
Rinsho shinkeigaku = Clinical neurologyAnti-NMDAR Encephalitis Following Herpes Simplex Virus Encephalitis: 2 Cases From Portugal.
The NeurohospitalistThe PET Sandwich: Using Serial FDG-PET Scans with Interval Burst Suppression to Assess Ictal Components of Disease.
Neurocritical careCerebral HSV-1 Vasculitis as a Fatal Complication of Immunosuppression in Non-Hodgkin´s Lymphoma: A Case Report and Review of the Literature.
Pathogens (Basel, Switzerland)Opsoclonus-myoclonus syndrome associated with herpes simplex virus infection: a case report.
The International journal of neuroscienceImmunomodulatory Strategies in Herpes Simplex Virus Encephalitis.
Clinical microbiology reviewsHerpes simplex virus encephalitis of childhood: inborn errors of central nervous system cell-intrinsic immunity.
Human geneticsDifferential Diagnosis of Autoimmune Encephalitis from Infectious Lymphocytic Encephalitis by Analysing the Lymphocyte Subsets of Cerebrospinal Fluid.
Analytical cellular pathology (Amsterdam)Brucellosis mimicking herpes simplex virus encephalitis.
The Lancet. Infectious diseasesHerpes simplex encephalitis in adult patients with MASP-2 deficiency.
PLoS pathogensHerpes Simplex Virus Encephalitis: Patterns of Epidemiology and Outcomes of Patients Admitted to the Intensive Care Unit in Texas, 2008 - 2016.
Journal of clinical medicine researchAn unusual cause of bowel ischemia in an intensive care unit patient with herpes simplex virus encephalitis.
Journal of surgical case reportsThe German trial on Aciclovir and Corticosteroids in Herpes-simplex-virus-Encephalitis (GACHE): a multicenter, randomized, double-blind, placebo-controlled trial.
Neurological research and practiceRapid detection of human herpes virus by next-generation sequencing in a patient with encephalitis.
Virology journalHerpes simplex virus encephalitis in a patient receiving ustekinumab associated with extensive cerebral oedema and brainshift successfully treated by immunosuppression with dexamethasone.
BMJ case reportsThe role of infections in autoimmune encephalitides.
Revue neurologiqueRecurrent Herpes Zoster Ophthalmicus in a Patient With a Novel Toll-Like Receptor 3 Variant Linked to Compromised Activation Capacity in Fibroblasts.
The Journal of infectious diseasesAutoimmune Glial Fibrillary Acidic Protein Astrocytopathy Following Herpes Simplex Virus Encephalitis in a Pediatric Patient.
Pediatric neurologyAcute hemorrhagic leukoencephalitis of Weston Hurst secondary to herpes encephalitis presenting as status epilepticus: A case report and review of literature.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaHerpes Simplex Virus 1 encephalitis with normal cerebrospinal fluid after brain radiotherapy in a patient with glioblastoma. A case report and review of literature.
Acta bio-medica : Atenei ParmensisHSV-Encephalitis Reactivation after Cervical Spine Surgery.
Case reports in surgeryLate-onset Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes Presenting With Auditory Agnosia.
The neurologistHerpes simplex virus encephalitis update.
Current opinion in infectious diseasesContinuous Electroencephalogram as a Biomarker of Disease Progression and Severity in Herpes Simplex Virus-1 Encephalitis.
Clinical EEG and neuroscienceDiagnosis and Management of Autoimmune Dementia.
Current treatment options in neurologyCerebral Venous Thrombosis as Rare Presentation of Herpes Simplex Virus Encephalitis.
Case reports in infectious diseasesThe psychopathology of NMDAR-antibody encephalitis in adults: a systematic review and phenotypic analysis of individual patient data.
The lancet. PsychiatryThe recruitment of peripheral blood leukocytes to the brain is delayed in susceptible BALB/c compared to resistant C57BL/6 mice during herpes simplex virus encephalitis.
Journal of neurovirologyCerebrovascular manifestations of herpes simplex virus infection of the central nervous system: a systematic review.
Journal of neuroinflammationRecurrent Herpes Simplex Virus Encephalitis After Epilepsy Surgery.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques[A 64-year-old male with recurrence of herpes simplex encephalitis after suffering from severe pneumonia and sepsis].
Rinsho shinkeigaku = Clinical neurologyLong-term outcome of acute central nervous system infection in children.
Pediatric investigationThe clinical approach to managing herpes simplex virus encephalitis.
British journal of hospital medicine (London, England : 2005)Herpes simplex virus encephalitis temporally associated with dimethyl fumarate-induced lymphopenia in a multiple sclerosis patient.
Multiple sclerosis and related disordersComparing molecular quantification of herpes simplex virus (HSV) in cerebrospinal fluid (CSF) with quantitative structural and functional disease severity in patients with HSV encephalitis (HSVE): Implications for improved therapeutic approaches.
Journal of clinical virology : the official publication of the Pan American Society for Clinical VirologyBoth IRF3 and especially IRF7 play a key role to orchestrate an effective cerebral inflammatory response in a mouse model of herpes simplex virus encephalitis.
Journal of neurovirologyInsular cortex lesion and autonomic instability in a herpes simplex virus encephalitis patient.
Journal of neurovirologyReal-time Utilization of Metagenomic Sequencing in the Diagnosis and Treatment Monitoring of an Invasive Adenovirus B55 Infection and Subsequent Herpes Simplex Virus Encephalitis in an Immunocompetent Young Adult.
Open forum infectious diseasesMultimodal management of severe herpes simplex virus encephalitis: A case report and literature review.
Neuro-ChirurgieAutoimmune Encephalitis Following Herpes Simplex Virus Encephalitis in an Infant.
Indian pediatricsAnti-N-methyl-d-aspartate receptor encephalitis in children: Incidence and experience in Hong Kong.
Brain & developmentHerpes Simplex Virus Encephalitis: Atypical Presentation as a Right Middle Cerebral Artery Stroke.
CureusSemantic language deficit developing following herpes simplex encephalitis: reorganization "cannibalising" language centers?
NeurocaseCytokine/chemokine elevation during the transition phase from HSV encephalitis to autoimmune anti-NMDA receptor encephalitis.
Brain & developmentPremature Termination of Treatment in Neonatal Herpes Simplex Virus Encephalitis.
Pediatric neurologyA Case of Bell's Palsy Complicated by Subsequent Herpes Simplex Virus Encephalitis.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiquesCare beyond the hospital ward: understanding the socio-medical trajectory of herpes simplex virus encephalitis.
BMC health services researchUse of high b value diffusion-weighted magnetic resonance imaging in acute encephalopathy/encephalitis during childhood.
Brain & developmentHerpes simplex encephalitis with thalamic, brainstem and cerebellar involvement.
The neuroradiology journalBurden of herpes simplex virus encephalitis in the United States.
Journal of neurologyExtended Clinical Spectrum of Anti-N-Methyl-d-Aspartate Receptor Encephalitis in Children: A Case Series.
Pediatric neurologyEpilepsy surgery for epileptic encephalopathy as a sequela of herpes simplex encephalitis: case report.
Journal of neurosurgery. PediatricsCerebrospinal fluid cyto-/chemokine profile during acute herpes simplex virus induced anti-N-methyl-d-aspartate receptor encephalitis and in chronic neurological sequelae.
Developmental medicine and child neurologyTLR3 Mutations in Adult Patients With Herpes Simplex Virus and Varicella-Zoster Virus Encephalitis.
The Journal of infectious diseasesPostviral autoimmune encephalitis: manifestations in children and adults.
Current opinion in neurologyNMDAR Encephalitis Following Herpes Simplex Virus Encephalitis.
Current infectious disease reportsExtratemporal herpes encephalitis during natalizumab treatment: A case report.
Multiple sclerosis and related disordersProtective role of CX3CR1 signalling in resident cells of the central nervous system during experimental herpes simplex virus encephalitis.
The Journal of general virologyAnti-N-methyl-D-aspartate receptor encephalitis after Herpes simplex virus-associated encephalitis: an emerging disease with diagnosis and therapeutic challenges.
InfectionDifferences in T cell cytotoxicity and cell death mechanisms between progressive multifocal leukoencephalopathy, herpes simplex virus encephalitis and cytomegalovirus encephalitis.
Acta neuropathologicaImproved CT Detection of Acute Herpes Simplex Virus Type 1 Encephalitis Based on a Frequency-Selective Nonlinear Blending: Comparison With MRI.
AJR. American journal of roentgenologyDiagnosis and Treatment of Central Nervous System Infections in the Emergency Department.
Emergency medicine clinics of North AmericaPoster 215 Gustatory Agnosia Following Herpes Simplex Virus Encephalitis: A Case Report.
PM & R : the journal of injury, function, and rehabilitationAcute retinal necrosis results in low vision in a young patient with a history of herpes simplex virus encephalitis.
Clinical & experimental optometryHerpes simplex encephalitis is linked with selective mitochondrial damage; a post-mortem and in vitro study.
Acta neuropathologicaNon-paraneoplastic limbic encephalitis and central nervous HHV-6B reactivation: Causality or coincidence?
Neuropathology : official journal of the Japanese Society of NeuropathologyClinical outcomes in children with herpes simplex encephalitis receiving steroid therapy.
Journal of clinical virology : the official publication of the Pan American Society for Clinical VirologyA study on viral CNS inflammation beyond herpes encephalitis.
Journal of neurovirologyThe Type I Interferon Response Determines Differences in Choroid Plexus Susceptibility between Newborns and Adults in Herpes Simplex Virus Encephalitis.
mBio[Cognitive Impairment in Patients with Bacterial Meningitis and Encephalitides].
Brain and nerve = Shinkei kenkyu no shinpoElaboration of a clinical and paraclinical score to estimate the probability of herpes simplex virus encephalitis in patients with febrile, acute neurologic impairment.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical MicrobiologyAbsent anti-N-methyl-D-aspartate receptor NR1a antibodies in herpes simplex virus encephalitis and varicella zoster virus infections.
The International journal of neuroscienceRecurrent Herpes Simplex Virus Encephalitis After Neurologic Surgery.
World neurosurgeryHSV Encephalitis with Normal CSF - A Case Report with Review of Literature.
Journal of clinical and diagnostic research : JCDRGroup B streptococcal meningitis in a previously healthy man.
BMJ case reports[Clinical characteristics, prognosis and genetic susceptibility of herpes simplex encephalitis in children].
Zhonghua er ke za zhi = Chinese journal of pediatricsHerpes simplex virus encephalitis in Peru: a multicentre prospective study.
Epidemiology and infectionInfiltration Pattern of Blood Monocytes into the Central Nervous System during Experimental Herpes Simplex Virus Encephalitis.
PloS one[Herpes simplex virus encephalitis during pregnancy: Maternal and neonatal outcomes].
Medicina clinicaAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Severe herpes simplex virus encephalitis complicated by atypical Takotsubo cardiomyopathy with left ventricular systolic dysfunction.
- Safety and efficacy of adjunct dexamethasone in adults with herpes simplex virus encephalitis in the UK (DexEnceph): a multicentre, observer-blind, randomised, phase 3, controlled trial.
- Effect of different doses of dexamethasone on the penetration of acyclovir across the blood-brain barrier.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences· 2026· PMID 41237865mais citado
- Dexamethasone in herpes simplex virus encephalitis: timely insights amid study limitations.
- Herpes Simplex Virus Encephalitis With Cerebellar Infarction and Cortical Laminar Necrosis.
- Neonatal herpes simplex virus encephalitis: a single-center retrospective study of 14 cases.
- Neuroimaging features of incontinentia pigmenti: prompting genetic confirmation.
- Voxel-based morphometry and functional connectivity changes are associated with cognitive function in herpes simplex virus encephalitis.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:1930(Orphanet)
- MONDO:0012521(MONDO)
- GARD:6649(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q19001292(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
