O Lúpus Cutâneo Subagudo (LCS) é um tipo de lúpus que afeta a pele. Ele pode aparecer como lesões de pele em forma de anel, que não deixam cicatrizes e surgem em áreas expostas ao sol, ou como placas que lembram a psoríase. O LCS está associado a anticorpos específicos chamados anti-Ro/SSA e pode ser provocado por medicamentos.
Introdução
O que você precisa saber de cara
O Lúpus Cutâneo Subagudo (LCS) é um tipo de lúpus que afeta a pele. Ele pode aparecer como lesões de pele em forma de anel, que não deixam cicatrizes e surgem em áreas expostas ao sol, ou como placas que lembram a psoríase. O LCS está associado a anticorpos específicos chamados anti-Ro/SSA e pode ser provocado por medicamentos.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 8 sintomas em outras categorias
Características mais comuns
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
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Patients with cutaneous lupus erythematosus (CLE) are highly susceptible to nonmelanoma skin cancers, including cutaneous squamous cell carcinoma (SCC). Despite the well-established involvement of plasmacytoid dendritic cells (pDCs) in CLE development, the exact role of pDCs in the pathogenesis of CLE-related SCC remains unclear. This report presents a case of SCC arising from a subacute cutaneous lupus erythematosus (SCLE) lesion. Histopathological examination revealed a notable decrease in CD123+ pDCs in the SCC lesion compared with that in the SCLE lesion in the same patient. pDCs may exert cytotoxic effects against cancer cells; thus, the absence of pDCs in the microenvironment of cutaneous SCC may facilitate immune evasion by cancer cells, thereby promoting tumor progression. These findings indicate the complex relationship between pDCs and cutaneous SCC development in patients with CLE. Future studies should clarify the role of pDCs in tumor surveillance and progression.
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A man in his 60s suffered from refractory, biopsy-proven subacute cutaneous lupus erythematosus that required chronic, moderate dose steroids to manage. His rash was accompanied by arthralgias and negative autoantibody testing. His subacute lupus erythematosus (SCLE) was responsive to tofacitinib, but thrombotic complications limited the use of this medication. He continued prednisone 20 mg daily to manage his symptoms until treatment with anifrolumab completely cleared his skin. During a subsequent prednisone taper, he developed a macrocytic anaemia and elevated liver function tests that continued to progress. Ultimately, a bone marrow biopsy and myeloid next-generation sequencing revealed cellular vacuoles and UBA1 gene mutation, respectively, consistent with a diagnosis of VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome. We believe the chronic steroid use to control his SCLE masked the underlying diagnosis for many years.
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📚 EuropePMC486 artigos no totalmostrando 196
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The Australasian journal of dermatologySubacute cutaneous lupus erythematosus in a patient with Sjögren's syndrome taking terbinafine for onychomycosis.
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JAMA dermatologyDiscoid Lupus Erythematosus Lesions Associated with Systemic Fluorouracil Agents: A Case Report and Review.
CureusSecukinumab-induced subacute cutaneous lupus erythematosus.
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The Journal of dermatologySubacute cutaneous lupus erythematosus with positive anti-Ro antibodies following palbociclib and letrozole treatment: A case report and literature review.
Journal of cutaneous pathologyDrug-induced anti-Ro positive subacute cutaneous lupus in a man treated with olmesartan.
Dermatology online journalSystemic 5-fluorouracil induced lupus erythematosus: a review of the literature.
Dermatology online journalAnastrozole-Induced Dermatitis: Report of a Woman with an Anastrozole-Associated Dermatosis and a Review of Aromatase Inhibitor-Related Cutaneous Adverse Events.
Dermatology and therapySuccessful ustekinumab treatment in a patient with psoriasis and subacute cutaneous lupus erythematosus.
International journal of dermatologyThree cases of subacute cutaneous lupus erythematosus associated with malignancy: a late paraneoplastic phenomenon.
Clinical and experimental dermatologyChildhood subacute cutaneous lupus erythematosus associated with transaminitis.
Clinical and experimental dermatologySubacute cutaneous lupus erythematosus with a possible paraneoplastic association with melanoma.
BMJ case reportsCapecitabine-induced Subacute Cutaneous Lupus Erythematosus.
Anais brasileiros de dermatologiaWidespread subacute cutaneous lupus erythematosus in a patient receiving checkpoint inhibitor immunotherapy with ipilimumab and nivolumab.
Dermatology online journalUV radiation exposure in welders: impact on the skin and eyes.
CutisClinicopathologic comparison of Rowell syndrome, erythema multiforme, and subacute cutaneous lupus erythematosus.
Journal of the American Academy of DermatologyToxic epidermal necrolysis-like subacute cutaneous lupus erythematosus associated with lung carcinoma.
BMJ case reports[Immunohistochemical analysis for C3d, C4d, IgG, IgG4, and CD123 in diagnosis of autoimmune skin diseases].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciencesMetastatic prostate cancer presenting as subacute cutaneous lupus erythematosus.
The Australasian journal of dermatologyRowell's Syndrome Triggered by Omeprazole.
Acta dermatovenerologica Croatica : ADCSubacute cutaneous lupus erythematosus induced by gemcitabine in 2 patients with pancreatic cancer.
JAAD case reportsCutaneous effects of antihypertensive drugs.
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografiaSubacute Cutaneous Lupus Erythematosus in a Male Patient on Multiple Antiepileptics Unmasked by Melatonin.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseasesHeterogeneous lupus-specific lesions and treatment outcome, in a single patient, over a period of time.
Clinical case reportsSubacute cutaneous lupus erythematosus leukoderma treated with melanocyte-keratinocyte transplantation procedure.
Journal of cosmetic dermatologyPrimary antiphospholipid syndrome during aromatase inhibitors therapy: A case report and review of the literature.
MedicineUstekinumab-induced subacute cutaneous lupus.
JAAD case reportsAre there distinct clinical and pathological features distinguishing idiopathic from drug-induced subacute cutaneous lupus erythematosus? A European retrospective multicenter study.
Journal of the American Academy of DermatologyAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Lúpus eritematoso cutâneo subagudo.
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Comunidades
Grupos ativos de quem convive com esta doença aqui no Raras
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Decreased Plasmacytoid Dendritic Cells in Cutaneous Squamous Cell Carcinoma Arising From Subacute Cutaneous Lupus Erythematosus: A Case Report.
- Subacute cutaneous lupus erythematosus secondary to intravenous immunoglobulin therapy for chronic inflammatory demyelinating polyneuropathy: A case report.
- Subacute cutaneous lupus erythematosus in a patient with Whipple's disease.
- Evolution of Subacute Cutaneous Lupus Erythematosus.
- Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome in a patient with subacute cutaneous lupus (SCLE).
- A conceptual model of the patient experience of cutaneous lupus erythematosus.
- Subacute cutaneous lupus erythematosus-like drug eruption after durvalumab treatment for squamous cell carcinoma.
- Discoid Lupus Erythematosus.
- A Case Report of a Rare Subacute Cutaneous Lupus Erythematosus with Chin Prostration.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:163525(Orphanet)
- MONDO:0015573(MONDO)
- Lupus Eritematoso Sistemico(PCDT · Ministério da Saúde)
- GARD:20042(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q7630706(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
