A miosite de sobreposição (OM) é uma forma de miopatia inflamatória idiopática (MII) caracterizada por miosite com pelo menos uma característica clínica e/ou de sobreposição de autoanticorpos.
Introdução
O que você precisa saber de cara
A miosite de sobreposição (OM) é uma forma de miopatia inflamatória idiopática (MII) caracterizada por miosite com pelo menos uma característica clínica e/ou de sobreposição de autoanticorpos.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 18 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 40 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Miosite de sobreposição
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Pesquisa ativa
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Pesquisa e ensaios clínicos
1 ensaios clínicos encontrados.
Publicações mais relevantes
Immunotherapies in autoimmune inflammatory myopathies: Rationale and therapeutic updates.
Autoimmune inflammatory myopathies (AIM) constitute a heterogeneous group of acquired myopathies with endomysial inflammation as a shared feature highlighting a potentially autoimmune inflammatory process amenable to immunotherapies. The disorders can be best classified as dermatomyositis, necrotizing autoimmune myositis, antisynthetase syndrome-overlap myositis, and inclusion body myositis. Because of clinical and immunohistologic heterogeneity but often overlapping pathophysiologic features among all major subsets, a correct diagnosis is critical from the outset to apply the most suitable and subset-specific immunotherapy. Advances in the immunopathologic characterization of autoimmune inflammatory myopathies have identified potentially mechanism-specific disease subsets that promise the application of targeted immunotherapies for better clinical outcomes. A number of recent clinical trials with biologic agents and monoclonal antibodies, regardless of the clinical outcome considering that several were negative, have collectively expanded our knowledge on the main pathogenic markers of autoimmunity associated with each AIM subset including the role of T-cell or B-cell factors, key cytokines, complement and various associated antibodies, or innate immunity factors. The paper summarizes the main clinical and histopathologic features of each myositis subtype, including overlapping or unique concepts of their immunopathogenic mechanisms, being mainly focused on applied immunotherapies and relevant controlled clinical trials discussing evidence-based efficacy according to the currently evolved therapeutic algorithm. The ongoing trials are also discussed highlighting those with promising future, if applied early in the disease, and the new immunotherapeutic interventions for the refractory AIM subsets.
Prevalence and Risk of Falls and Fractures in the Idiopathic Inflammatory Myopathies: A Cross-Sectional Study of 470 Patients.
Patients with idiopathic inflammatory myopathies (IIMs) can develop marked muscle weakness, which predisposes them to falls and injuries. We examined the prevalence of falls and associated fractures, assistive device use, and bone-protective therapy use among those reporting a fracture history. This analysis focuses on secondary prevention strategies in a high-risk population. A cross-sectional survey was developed and distributed by Myositis Support and Understanding, a patient-led advocacy organization, to members of its group. Patients aged ≥ 18 years with a diagnosis of an IIM (dermatomyositis, antisynthetase syndrome, polymyositis, inclusion body myositis [IBM], immune-mediated necrotizing myopathy, or overlap myositis [OM]) were eligible to participate. Ordinal logistic regression was utilized to identify variables independently associated with falls. Of 470 respondents, 79.8% reported falling once since diagnosis, and 57.0% fell within the past year. Fall-related fractures since diagnosis were reported by 121 participants (25.7%), of whom 61 (50.4%) experienced ≥ 2 fractures and 39 (32.2%) required surgical treatment. Among those with fall-related fractures, nearly half (47.9%) reported not receiving any dietary supplements or pharmacologic therapies (e.g., calcium, vitamin D, or bisphosphonates) to reduce bone loss or prevent future fractures. Use of braces/splints or mobility aids was reported by 18.2% and 77.7% of participants with fall-related fractures, respectively. Regression analyses identified mobility aid usage as being associated with a significantly increased fall risk (odds ratio [OR], 3.1; P < 0.001). Relative to dermatomyositis, fall risk was significantly higher among participants with IBM (OR, 2.5; P = 0.002) and polymyositis (OR, 2.0; P = 0.037) and lower for participants with antisynthetase syndrome (OR, 0.5; P = 0.038). All IIMs can lead to marked weakness, with varying individual risks of falls. Multidisciplinary care, with an emphasis on primary and secondary prevention of falls and fractures, is critical to improving outcomes and preserving quality of life in these patient populations. People with idiopathic inflammatory myopathies, a group of diseases that cause muscle inflammation and weakness, often experience significant challenges that can affect their daily activities and make them more prone to falls and injuries. A survey conducted by Myositis Support and Understanding asked its members with idiopathic inflammatory myopathies about their experience with falls, bone fractures, and treatments for their condition. The results showed that 79.8% of the 470 survey respondents had fallen at least once since their diagnosis and 57.0% had fallen in the past year. Among the 25.7% of people who experienced fall-related fractures, half of them had multiple fractures, and nearly one-third needed surgery. Nearly half of the people who had fractures from falls said they were not taking any vitamins, supplements, or medications—like calcium, vitamin D, or bone-strengthening drugs—to help protect their bones or prevent more fractures. To help with mobility, 18.2% of people used braces or splints, and 77.7% used mobility aids such as walkers or canes. People with inclusion body myositis and people with polymyositis had a higher risk of falling compared with those with dermatomyositis. Although all types of idiopathic inflammatory myopathies can cause serious muscle weakness, some may increase the risk of falls more than others. Preventing falls and fractures is critical for improving the quality of life of people with idiopathic inflammatory myopathies.
Clinical profiles associated with rapidly progressive interstitial lung disease in antisynthetase syndrome: A multicentric cohort study (TYPASS study).
To assess factors associated with rapidly progressive interstitial lung disease (ILD) (RP-ILD) at time of ILD diagnosis in a multicentric retrospective cohort study of antisynthetase syndrome (ASyS). We used a complementary unsupervised approach, hierarchical clustering, to delineate distinct phenotypes among ASyS patients with ILD. A total of 132 patients with ASyS, defined according to the 2024 ACR/European Alliance of Associations for Rheumatology (EULAR) ASyS classification criteria, and ILD, diagnosed by CT scan, were included. RP-ILD was defined by the presence of respiratory failure at ILD diagnosis or rapid ILD progression during the first 3 months. In our study, 39% of patients had RP-ILD at ILD diagnosis. Multivariate logistic regression analysis with cluster-robust SE identified the factors associated with RP-ILD at ILD diagnosis as male sex (aOR = 9.7 [1.6-59.5], p = 0.006), fever (aOR = 128 [12.6-1300], p < 0.001), organizing pneumonia (OP) pattern (aOR = 66.8 [3.4-1316], p = 0.006), and pleural effusion (aOR = 20.2 [1.1-373], p = 0.04), whereas RP-ILD was associated with lower likelihood of severe muscle disease (aOR = 0.004 [0.0001-0.13], p = 0.002). Clustering analysis identified four distinct groups: Cluster 1 (n = 62) included patients with systemic presentation, non-RP-ILD at ILD diagnosis, and anti-Jo-1 antibodies with good prognosis; Cluster 2 (n = 40) included older age patients with more RP-ILD at ILD diagnosis, pleuropericarditis, and a higher mortality rate. Fever, pleural effusion, and OP pattern were independently associated with RP-ILD in ASyS patients. Unsupervised cluster analysis identified a severe inflammatory phenotype in ASyS patients with ILD.
Factors associated with interstitial lung disease among patients with idiopathic inflammatory myopathies.
Idiopathic inflammatory myopathies (IIM) are heterogeneous disorders that often affect the lungs as IIM-associated interstitial lung disease (IIM-ILD). We used Meta-ANalysis of Transethnic Associations (MANTRA) and machine learning methods to evaluate predictors of IIM-ILD. Subjects (N = 450) were enrolled in studies at the National Institutes of Health. We studied adult (N = 262) and juvenile (N = 188) DM (N = 276), PM (N = 109) and overlap myositis (N = 61) patients with clinical, autoantibody, HLA, and single nucleotide polymorphism (SNP) data, with (N = 162) or without (N = 288) ILD. Logistic regression and MANTRA analyses were used to evaluate the associations of SNPs (Muc5b rs35705950, TOLLIP rs5743890 and rs3750920, TLR5 rs5744168, and TERT rs2736100) previously identified as risks for idiopathic pulmonary fibrosis (IPF). Classification and regression tree (CART) and gradient boosting machine learning were used to simultaneously evaluate the clinical, autoantibody, HLA and SNP data for their relative predictive power of ILD. Smoking status, older age, African American heritage and certain HLA genes were associated with IIM-ILD, but anti-synthetase, myositis-associated and anti-MDA5 autoantibodies showed the strongest risk associations, with an increased odds of ILD by up to 20-fold. Conversely, anti-signal recognition particle, anti-TIF1 (P155/140) and anti-NXP2 autoantibodies showed the strongest protective effects, with decreased odds of ILD by up to 40%. The effects of some HLA allele groups and IPF SNPs on ILD were inconsistent and weaker. This sample of IIM patients showed autoantibodies to be the strongest predictive or protective factors for ILD, yet the full range of associations of IIM-ILD remain undefined.
Autoantibody internalization in myositis skeletal muscle: Emerging evidence, mechanistic insights, and therapeutic relevance.
The inflammatory myopathies-including dermatomyositis, immune-mediated necrotizing myopathy, anti-synthetase syndrome, and overlap myositis-are systemic autoimmune diseases characterized by myositis-specific and myositis-associated autoantibodies targeting intracellular antigens. These diseases can be subclassified by autoantibody seropositivity, based on the understanding that each myositis autoantibody is associated with distinct clinical features. Traditionally, given the intracellular nature of their targets, myositis autoantibodies were thought to be non-pathogenic. However, this idea is now being challenged based on data from recent and older studies showing that autoantibodies reach their intracellular targets in vivo and exert functional pathogenic effects. In this review, we summarize experimental evidence supporting a model of pathogenic autoantibody internalization in the skeletal muscle of different inflammatory myopathies. We also address gaps in the evidence for this model, including the lack of a proven mechanism of autoantibody entry, while offering suggestions for future studies to fill these gaps. We discuss possible mechanisms of autoantibody entry, as well as the diagnostic, prognostic, and therapeutic implications of this model. Finally, we propose that autoantibodies targeting intracellular antigens in other autoimmune diseases-including certain autoimmune neurologic disorders, systemic sclerosis, systemic lupus erythematosus, and vasculitis-could potentially play a role in these conditions.
Publicações recentes
Lung transplant outcomes in myositis, systemic sclerosis and idiopathic pulmonary fibrosis: a multicenter retrospective analysis.
Characterization of Antinuclear, Myositis-Specific, and Myositis-Associated Antibodies in a Large Sample of Patients With Idiopathic Inflammatory Myopathies.
Malignancy in anti-synthetase syndrome: clinical features and prognostic impact from a multicenter retrospective study.
Spectrum of clinical phenotypes associated with myositis-specific and myositis-associated antibodies in juvenile idiopathic inflammatory myositis: Our experience from North India.
Prevalence and Risk of Falls and Fractures in the Idiopathic Inflammatory Myopathies: A Cross-Sectional Study of 470 Patients.
📚 EuropePMC19 artigos no totalmostrando 137
Prevalence and Risk of Falls and Fractures in the Idiopathic Inflammatory Myopathies: A Cross-Sectional Study of 470 Patients.
Rheumatology and therapyImmunotherapies in autoimmune inflammatory myopathies: Rationale and therapeutic updates.
Handbook of clinical neurologyPregnancy outcomes in idiopathic inflammatory myopathies: a Portuguese multicentre study.
Frontiers in medicineClinical profiles associated with rapidly progressive interstitial lung disease in antisynthetase syndrome: A multicentric cohort study (TYPASS study).
Journal of internal medicineUse of rituximab for fulminant and refractory cases of immune checkpoint inhibitor induced myocyte injury clinically presenting with features of myasthenia gravis: a case series.
European heart journal. Case reportsFactors associated with interstitial lung disease among patients with idiopathic inflammatory myopathies.
Rheumatology (Oxford, England)Autoantibody internalization in myositis skeletal muscle: Emerging evidence, mechanistic insights, and therapeutic relevance.
Autoimmunity reviewsOverall and by subtype epidemiology of idiopathic inflammatory myopathies among African descent patients with free access to high standard healthcare.
Seminars in arthritis and rheumatismThe SCRIM score: a clinical tool for cancer risk-stratification in patients with idiopathic inflammatory myopathy.
Arthritis research & therapyEnhanced proteasome activity in perifascicular myofibres is a hallmark of dermatomyositis and its inhibition is efficient in preclinical models.
Annals of the rheumatic diseasesNon-targeted immunosuppressive and immunomodulatory therapies for idiopathic inflammatory myopathies.
The Cochrane database of systematic reviewsTargeted immunosuppressive and immunomodulatory therapies for idiopathic inflammatory myopathies.
The Cochrane database of systematic reviewsRemission and low disease activity definitions in adult idiopathic inflammatory myopathies: A narrative review by myositis clinical trials consortium (MCTC).
Autoimmunity reviewsInfections preceding diagnosis associated with myositis phenotypes in a national patient registry.
Clinical and experimental rheumatologyA case of myositis associated with mixed connective tissue disease mimicking bilateral posterior interosseous nerve palsy.
Ideggyogyaszati szemleModulating IL-21-driven B cell responses in idiopathic inflammatory myopathies via inhibition of the JAK/STAT pathway.
Arthritis research & therapyCardiovascular events in patients with myositis: results from a French retrospective cohort.
RMD openWhat is in the Myopathy Literature?
Journal of clinical neuromuscular diseasePatients with anti-PM/Scl-positive and idiopathic inflammatory myopathy resemble anti-synthetase syndrome.
Advances in rheumatology (London, England)The utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies: a scoping review.
Frontiers in immunologyMagnetic resonance imaging in idiopathic inflammatory myopathies: deciphering the pattern of muscle involvement.
Neuromuscular disorders : NMDType I interferon biomarker in idiopathic inflammatory myopathies: associations of Siglec-1 with disease activity and treatment response.
Rheumatology (Oxford, England)Occupational and Hobby Exposures Associated With Myositis Phenotypes in a National Myositis Patient Registry.
Arthritis care & researchNot Just Myocarditis: Mixed Connective Tissue Disease (MCTD) and Overlap Myositis With Anti-Ku Positivity in a Young Male With Shortness of Breath.
CureusIncidence and outcomes for children with idiopathic inflammatory myopathy in Western Australia-a long-term population-based study.
International journal of rheumatic diseasesContribution of major histocompatibility complex class II immunostaining in distinguishing idiopathic inflammatory myopathy subgroups: A histopathological cohort study.
Journal of neuropathology and experimental neurologyCurrent efforts and historical perspectives on classification of idiopathic inflammatory myopathies.
Current opinion in rheumatologyAnti-Ku + myositis: an acquired inflammatory protein-aggregate myopathy.
Acta neuropathologicaAnti-HMGCR (Hydroxy-3-Methylglutaryl-CoA Reductase) Myopathy: A Rare Cause of Proximal Muscle Weakness.
CureusImmunohistochemical expression in idiopathic inflammatory myopathies at a single center in Vietnam.
Journal of pathology and translational medicineExtracorporeal membrane oxygenation for acute lung injury in idiopathic inflammatory myopathies-a potential lifesaving intervention.
Rheumatology (Oxford, England)Autoantibody evaluation in idiopathic inflammatory myopathies.
Advances in clinical chemistryImpaired health-related quality of life in idiopathic inflammatory myopathies: a cross-sectional analysis from the COVAD-2 e-survey.
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Clinical and experimental rheumatologyQuantitative whole-body muscle MRI in idiopathic inflammatory myopathies including polymyositis with mitochondrial pathology: indications for a disease spectrum.
Journal of neurologyPerformance of the 2017 EULAR/ACR Classification Criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups: a scoping review.
Clinical and experimental rheumatologyShrinking lung syndrome mimicking diaphragmatic palsy in systemic lupus erythematosus.
Practical neurologyCancer Risk and Mortality in Hospitalized Patients With Idiopathic Inflammatory Myopathies in Western Australia.
The Journal of rheumatologyLong Term Outcomes in Idiopathic Inflammatory Myositis: An Observational Epidemiologic Study over 15 Years.
Mediterranean journal of rheumatologyMyositis-Associated Autoantibodies in Patients With Juvenile Myositis Are Associated With Refractory Disease and Mortality.
Arthritis & rheumatology (Hoboken, N.J.)Contribution of Complement, Microangiopathy and Inflammation in Idiopathic Inflammatory Myopathies.
Journal of neuromuscular diseasesComparison of Muscle Biopsy Features with Myositis Autoantibodies in Inflammatory Myopathies: A Pilot Experience.
Annals of Indian Academy of NeurologyDisease spectrum of myopathies with elevated aldolase and normal creatine kinase.
European journal of neurologyRetrospective Study Shows That Serum Levels of Chemokine CXCL10 and Cytokine GDF15 Support a Diagnosis of Sporadic Inclusion Body Myositis and Immune-Mediated Necrotizing Myopathy.
Brain sciencesDetection of Myositis Autoantibodies by Multi-Analytic Immunoassays in a Large Multicenter Cohort of Patients with Definite Idiopathic Inflammatory Myopathies.
Diagnostics (Basel, Switzerland)The spectrum of idiopathic inflammatory myopathies in Western Australia: epidemiological characteristics and mortality over time.
Rheumatology internationalGender differences in patient experience in idiopathic inflammatory myopathies: Subanalysis from the COVAD dataset.
Modern rheumatologyImpact of SARS-CoV-2 on the clinical presentation of juvenile idiopathic inflammatory myopathies.
Pediatric rheumatology online journalAutoimmune inflammatory myopathies.
Handbook of clinical neurologyInaugural dropped head syndrome and camptocormia in inflammatory myopathies: a retrospective study.
Rheumatology (Oxford, England)Long-term safety of COVID vaccination in individuals with idiopathic inflammatory myopathies: results from the COVAD study.
Rheumatology internationalThe longitudinal study of muscle changes with ultrasound: differential changes in idiopathic inflammatory myopathy subgroups.
Rheumatology (Oxford, England)Joint and muscle inflammatory disease: A scoping review of the published evidence.
Seminars in arthritis and rheumatismMyasthenia gravis-myositis association: is it an overlap myositis or a distinct entity?
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyMyositis-related autoantibody profile and clinical characteristics stratified by anti-cytosolic 5'-nucleotidase 1A status in connective tissue diseases.
Muscle & nerveOverlap syndrome with antibodies against multiple transfer-RNA components presenting antisynthetase syndrome.
Neuromuscular disorders : NMDNovel aspects of muscle involvement in immune-mediated inflammatory arthropathies and connective tissue diseases.
Autoimmunity reviewsPain in individuals with idiopathic inflammatory myopathies, other systemic autoimmune rheumatic diseases, and without rheumatic diseases: A report from the COVAD study.
International journal of rheumatic diseasesLong-term survival of patients with idiopathic inflammatory myopathies: anatomy of a single-centre cohort.
Clinical and experimental rheumatologyUtility of Myositis-Specific Autoantibodies for Treatment Selection in Myositis.
Current treatment options in rheumatologyDistal upper limb involvement in myasthenia-myositis association.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyInflammatory myopathies: an update for neurologists.
Arquivos de neuro-psiquiatriaMuscle B mode ultrasound and shear-wave elastography in idiopathic inflammatory myopathies (SWIM): criterion validation against MRI and muscle biopsy findings in an incident patient cohort.
BMC rheumatologyExperience with the use of mycophenolate mofetil in juvenile idiopathic inflammatory myopathies.
Rheumatology (Oxford, England)A Large Cluster of New Onset Autoimmune Myositis in the Yorkshire Region Following SARS-CoV-2 Vaccination.
VaccinesAutoimmune Idiopathic Inflammatory Myopathies: Pharmacological Differences and Similarities by Type of Myositis and by Sociodemographic Variables.
International journal of rheumatologyNailfold capillaroscopy changes with disease activity in patients with inflammatory myositis including overlap myositis, pure dermatomyositis, and pure polymyositis.
ReumatologiaGenetics and Autoimmunity: Two Sides of the Same Coin or an Epiphenomenon?
Mediterranean journal of rheumatologyEvolving classification and role of muscle biopsy in diagnosis of inflammatory myopathies.
Indian journal of pathology & microbiologyClinical, Serological, and Genetic Characteristics of a Hungarian Myositis-Scleroderma Overlap Cohort.
BioMed research internationalPathophysiological Mechanisms and Treatment of Dermatomyositis and Immune Mediated Necrotizing Myopathies: A Focused Review.
International journal of molecular sciencesAntibody Therapies in Autoimmune Inflammatory Myopathies: Promising Treatment Options.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeuticsComplement in autoimmune inflammatory myopathies, the role of myositis-associated antibodies, COVID-19 associations, and muscle amyloid deposits.
Expert review of clinical immunologySIGLEC1 enables straightforward assessment of type I interferon activity in idiopathic inflammatory myopathies.
RMD openAn Italian Multicenter Study on Anti-NXP2 Antibodies: Clinical and Serological Associations.
Clinical reviews in allergy & immunologyPrevalent Drug Usage Practices in Adults and Children With Idiopathic Inflammatory Myopathies: Registry-Based Analysis From the MyoCite Cohort.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseasesMorphological Characteristics of Idiopathic Inflammatory Myopathies in Juvenile Patients.
CellsInterstitial pneumonia with autoimmune features: Evaluation of connective tissue disease incidence during follow-up.
European journal of internal medicine[Clinical and immunological characteristics of 88 cases of overlap myositis].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciencesIdiopathic inflammatory myopathies.
Nature reviews. Disease primersInflammatory myopathies: shedding light on promising agents and combination therapies in clinical trials.
Expert opinion on investigational drugsIdiopathic inflammatory myopathies: a review.
Internal medicine journalMyositis autoantibodies in a racially diverse population of children with idiopathic inflammatory myopathies.
Pediatric rheumatology online journalComparison of the 2017 EULAR/ACR Criteria with Clinicoserologic Criteria for the Classification of Idiopathic Inflammatory Myopathies in Korean Patients.
Yonsei medical journalPeripheral nervous system manifestations of rheumatological diseases.
Journal of the neurological sciencesCutaneous ulceration and digital gangrene in an anti-MDA5-positive overlap myositis.
Rheumatology (Oxford, England)A Case Report of Anorectal Squamous Cell Carcinoma Associated with Overlap Myositis Syndrome-a Possible Paraneoplastic Myositis Syndrome.
Clinical colorectal cancerInflammatory myopathies: update on diagnosis, pathogenesis and therapies, and COVID-19-related implications.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of MyologyCharacteristics and outcomes of overlap myositis: a comparative multigroup cohort study in adults from the MyoCite cohort.
Rheumatology internationalPolymyositis: is there anything left? A retrospective diagnostic review from a tertiary myositis centre.
Rheumatology (Oxford, England)Myositis-specific and myositis-associated autoantibodies in a large Indian cohort of inflammatory myositis.
Seminars in arthritis and rheumatismFrom Diagnosis to Prognosis: Revisiting the Meaning of Muscle ISG15 Overexpression in Juvenile Inflammatory Myopathies.
Arthritis & rheumatology (Hoboken, N.J.)What is New in Idiopathic Inflammatory Myopathies: Mechanisms and Therapies.
Annals of Indian Academy of NeurologyThe significance of myositis autoantibodies in idiopathic inflammatory myopathy concomitant with interstitial lung disease.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyPredictive Features and Clinical Presentation of Interstitial Lung Disease in Inflammatory Myositis.
Clinical reviews in allergy & immunologyIntravenous immunoglobulins as first-line treatment in idiopathic inflammatory myopathies: a pilot study.
Rheumatology (Oxford, England)Secondary Causes of Myositis.
Current treatment options in neurologyRelationship between change in physical activity and in clinical status in patients with idiopathic inflammatory myopathy: A prospective cohort study.
Seminars in arthritis and rheumatismExternal validation of the EULAR/ACR idiopathic inflammatory myopathies classification criteria with a Japanese paediatric cohort.
Rheumatology (Oxford, England)Outcomes of Pregnancy in Women With Inflammatory Myositis: A Cohort Study From India.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseasesInflammatory Myopathies: Utility of Antibody Testing.
Neurologic clinics[Idiopathic Inflammatory Myopathies].
Deutsche medizinische Wochenschrift (1946)Trends in idiopathic inflammatory myopathies: cross-sectional data from the German National Database.
Rheumatology internationalMachine learning algorithms reveal unique gene expression profiles in muscle biopsies from patients with different types of myositis.
Annals of the rheumatic diseasesThe spectrum of idiopathic inflammatory myopathies in South Africa.
Clinical rheumatologyImmune-Mediated Myopathies.
Continuum (Minneapolis, Minn.)Anti-MDA5 juvenile idiopathic inflammatory myopathy: a specific subgroup defined by differentially enhanced interferon-α signalling.
Rheumatology (Oxford, England)Nailfold videocapillaroscopy alterations in dermatomyositis, antisynthetase syndrome, overlap myositis, and immune-mediated necrotizing myopathy.
Clinical rheumatologyDiagnostic value of additional histopathological fascia examination in idiopathic inflammatory myopathies.
European journal of neurologyPhysical therapy in adult inflammatory myopathy patients: a systematic review.
Clinical rheumatologyOverlap myositis, a distinct entity beyond primary inflammatory myositis: A retrospective analysis of a large cohort from the REMICAM registry.
International journal of rheumatic diseasesResponsiveness to Change of 5-point MRC scale, Endurance and Functional Evaluation for Assessing Myositis in Daily Clinical Practice.
Journal of neuromuscular diseasesJuvenile idiopathic inflammatory myopathies: A clinicopathological study with emphasis on muscle histology.
Indian journal of pathology & microbiology18F-FDG PET/CT versus conventional investigations for cancer screening in autoimmune inflammatory myopathy in the era of novel myopathy classifications.
Nuclear medicine communicationsAutoantibodies in idiopathic inflammatory myopathies: Clinical associations and laboratory evaluation by mono- and multispecific immunoassays.
Autoimmunity reviewsLong-term pulmonary outcomes and mortality in idiopathic inflammatory myopathies associated with interstitial lung disease.
Clinical rheumatologyMuscle disease in scleroderma.
Current opinion in rheumatologyClassification and management of adult inflammatory myopathies.
The Lancet. NeurologyPrevalence and clinical correlates of rheumatoid factor and anticitrullinated protein antibodies in patients with idiopathic inflammatory myopathy.
RMD openThe clinico-serological spectrum of overlap myositis.
Current opinion in rheumatologyC4d as a marker of complement activation in dermatomyositis muscle tissue.
Neurology IndiaImmune checkpoint failures in inflammatory myopathies: An overview.
Autoimmunity reviewsCurrent Classification and Management of Inflammatory Myopathies.
Journal of neuromuscular diseasesAnti-NT5C1A autoantibodies are associated with more severe disease in patients with juvenile myositis.
Annals of the rheumatic diseasesMortality and prognostic factors in idiopathic inflammatory myositis: a retrospective analysis of a large multicenter cohort of Spain.
Rheumatology internationalSubcutaneous IgG in the Myositis Spectrum Disorders.
Current rheumatology reviewsProfile of Pediatric Idiopathic Inflammatory Myopathies from a Tertiary Care Center of Eastern India.
Indian journal of pediatricsWhole-body MRI for full assessment and characterization of diffuse inflammatory myopathy.
Acta radiologica openMulticenter registry on inflammatory myositis from the Rheumatology Society in Madrid, Spain: Descriptive Analysis.
Reumatologia clinicaMyopathy in scleroderma and in other connective tissue diseases.
Current opinion in rheumatologyAdvances in serological diagnostics of inflammatory myopathies.
Current opinion in neurologyWhy do patients with myositis die? A retrospective analysis of a single-centre cohort.
Clinical and experimental rheumatologyClinical and serological associations of autoantibodies to the Ku70/Ku80 heterodimer determined by a novel chemiluminescent immunoassay.
LupusInflammatory myopathies and overlap syndromes: Update on histological and serological profile.
Best practice & research. Clinical rheumatologyThe juvenile idiopathic inflammatory myopathies: pathogenesis, clinical and autoantibody phenotypes, and outcomes.
Journal of internal medicineMosaic Tetrasomy 9p: A Mendelian Condition Associated With Pediatric-Onset Overlap Myositis.
PediatricsIdiopathic inflammatory myopathies and the lung.
European respiratory review : an official journal of the European Respiratory SocietyAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Immunotherapies in autoimmune inflammatory myopathies: Rationale and therapeutic updates.
- Prevalence and Risk of Falls and Fractures in the Idiopathic Inflammatory Myopathies: A Cross-Sectional Study of 470 Patients.
- Clinical profiles associated with rapidly progressive interstitial lung disease in antisynthetase syndrome: A multicentric cohort study (TYPASS study).
- Factors associated with interstitial lung disease among patients with idiopathic inflammatory myopathies.
- Autoantibody internalization in myositis skeletal muscle: Emerging evidence, mechanistic insights, and therapeutic relevance.
- Lung transplant outcomes in myositis, systemic sclerosis and idiopathic pulmonary fibrosis: a multicenter retrospective analysis.
- Characterization of Antinuclear, Myositis-Specific, and Myositis-Associated Antibodies in a Large Sample of Patients With Idiopathic Inflammatory Myopathies.
- Malignancy in anti-synthetase syndrome: clinical features and prognostic impact from a multicenter retrospective study.
- Spectrum of clinical phenotypes associated with myositis-specific and myositis-associated antibodies in juvenile idiopathic inflammatory myositis: Our experience from North India.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:206572(Orphanet)
- MONDO:0016099(MONDO)
- GARD:20352(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Q55785928(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
