Raras
Buscar doenças, sintomas, genes...
Eritema pigmentado fixo
ORPHA:293812CID-10 · L25.1CID-11 · EH66DOENÇA RARA

Reação de hipersensibilidade rara caracterizada pelo aparecimento de placas eritematosas ou violáceas, redondas, às vezes dolorosas, que podem ou não resultar em pigmentação duradoura e que são recorrentes (geralmente no mesmo local) após reexposição ao medicamento causador. A forma grave da doença, erupção bolhosa generalizada fixa por medicamento, ocorre tipicamente em idosos e pode ser fatal. O início geralmente ocorre 30 minutos a várias horas após a administração do medicamento causal. Muitos medicamentos, incluindo o paracetamol, foram implicados. A doença raramente pode ser induzida por alimentos. A histologia é caracterizada por dermatite de interface ou necrólise epidérmica nas formas bolhosas.

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Introdução

O que você precisa saber de cara

📋

Reação de hipersensibilidade rara observada pelo aparecimento de placas eritematosas ou violáceas, redondas, às vezes dolorosas, que podem ou não resultar em pigmentação rigorosa e que são recorrentes (geralmente no mesmo local) após reexposição ao medicamento causador. A forma grave da doença, herança bolhosa generalizada fixada por medicamento, ocorre tipicamente em idosos e pode ser fatal. O início geralmente ocorre 30 minutos a várias horas após a administração do medicamento causal. Muitos medicamentos, incluindo o paracetamol, foram implicados. Uma doença recentemente pode ser causada por alimentos. A histologia é caracterizada por dermatite de interface ou necrólise epidérmica nas formas bolhosas.

Publicações científicas
1.173 artigos
Último publicado: 2026 Apr 12

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: L25.1
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Entender a doença

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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Características mais comuns

90%prev.
Resposta adversa a medicamentos
Muito frequente (99-80%)
90%prev.
Eritema
Muito frequente (99-80%)
90%prev.
Alergia a medicamentos
Muito frequente (99-80%)
55%prev.
Cisão juncional
Frequente (79-30%)
55%prev.
Placa eritematosa
Frequente (79-30%)
55%prev.
Anormalidade regional da pele
Frequente (79-30%)
18sintomas
Muito frequente (3)
Frequente (3)
Ocasional (8)
Muito raro (4)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 18 características clínicas mais associadas, ordenadas por frequência.

Resposta adversa a medicamentosAdverse drug response
Muito frequente (99-80%)90%
EritemaErythema
Muito frequente (99-80%)90%
Alergia a medicamentosDrug allergy
Muito frequente (99-80%)90%
Cisão juncionalJunctional split
Frequente (79-30%)55%
Placa eritematosaErythematous plaque
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico1.173PubMed
Últimos 10 anos200publicações
Pico202551 papers
Linha do tempo
2026Hoje · 2026🧪 2014Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

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Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

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Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
·Pré-clínico1
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 1 ensaio
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Eritema pigmentado fixo

🗺️

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Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

1 ensaios clínicos encontrados.

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Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
465 papers (10 anos)
#1

Nimesulide-Associated Generalized Bullous Fixed Drug Eruption: A Rare Pharmacovigilance Case Report.

Cureus2026 Jan

Generalized Bullous Fixed Drug Eruption (GBFDE) is a severe variant of Fixed Drug Eruption (FDE) characterized by widespread dusky erythematous plaques and blistering, often mimicking Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN). Early distinction is critical, as misdiagnosis can lead to delayed or inappropriate management. We report a case of nimesulide-induced GBFDE in a 32-year-old male who developed rapidly progressing dusky plaques and flaccid bullae within 24 hours of self-medicating with an over-the-counter Nimesulide formulation. A prior similar episode following exposure to the same drug strongly supported the diagnosis. Prompt withdrawal of the drug, systemic corticosteroids, and supportive care led to rapid clinical improvement. This case highlights the diagnostic challenges, the dangers of over-the-counter NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) use, and the importance of pharmacovigilance reporting, given that only three cases of nimesulide-associated GBFDE have been documented to date. Increased awareness among clinicians is essential to prevent morbidity and recognize this rare but potentially life-threatening adverse reaction.

#2

Fixed Drug Eruptions in Malagasy Children: Clinical Observations and Characteristics.

Case reports in dermatological medicine2026

Fixed drug eruption is a drug-induced hypersensitivity reaction characterized by recurrent erythematous-pigmented lesions at the same site after each exposure to the causative drug. The molecules most frequently implicated are sulfonamides, nonsteroidal anti-inflammatory drugs, anticonvulsants, and paracetamol. The first case involved a four-year-old boy with sickle cell disease who had presented with a recurrent hyperpigmented macule on the lip for 1 year. The second case involved a three-year-old girl with multiple pigmented, pruritic macules. The third case involved a ten-year-old boy presenting with pigmented plaques and flaccid bullae on his arm and left thigh. In all three cases, fixed drug eruption (including one bullous form) was diagnosed based on the patient history and recurrence. Management consisted of permanent withdrawing of the offending drug and providing symptomatic treatment with antihistamines and topical corticosteroids. There were favorable outcomes, but persistent residual pigmentation remained. These three cases illustrate the typical clinical presentation of fixed drug eruption in children in Madagascar. Recurrence of the same lesion at the same site is pathognomonic and requires discontinuation of the offending drug and reporting to pharmacovigilance.

#3

Fluconazole-Induced Fixed Drug Eruption With Cross-Reactivity to Clotrimazole-Confirmation With Patch Testing.

Case reports in dermatological medicine2026

First described in 1994, fixed drug eruption (FDE) to fluconazole is uncommon but possibly underdiagnosed. Of these, women with vaginal candidiasis remain the most affected, with on average more than four occurrences prior to diagnosis. We present a case of a 29-year-old female who presented after her third episode of an itchy, oedematous, blistering rash on her right hand that developed 2 h following ingestion of 150 mg of fluconazole. She reported two similar episodes in the 2 years prior, all following administration of fluconazole for vaginal candidiasis. Each episode resulted in a rash localized to her right hand, with each subsequent exposure resulting in faster onset of symptoms and signs. A FDE to fluconazole was suspected clinically, and lesional skin biopsies were consistent with this. The diagnosis was confirmed with a positive patch test to 5% fluconazole applied to the affected skin on the right hand. Cross-reactivity with clotrimazole was confirmed with a positive patch test to clotrimazole 5%. She was subsequently advised to avoid both fluconazole and clotrimazole. Although cross-reactivity between different azole antifungal agents has been described, cross-reactivity between fluconazole and clotrimazole is a novel finding. This case raises awareness of FDE to fluconazole, in particular for women being treated for vaginal candidiasis, and highlights the importance of patch testing to other antifungal agents to assess for cross-reactivity.

#4

Generalized Bullous Fixed Drug Eruption: A Systematic Review.

The journal of allergy and clinical immunology. In practice2026 Mar

Generalized bullous fixed drug eruption (GBFDE) is a severe cutaneous adverse reaction characterized by widespread plaques with bullae. Although regarded as less severe than Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), emerging reports suggest GBFDE may be similarly life-threatening. Comprehensive characterization of GBFDE remains lacking. To review the epidemiology, causative agents, clinical features, histology, outcomes, and management of GBFDE. We conducted a systematic review according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched PubMed and Embase databases for studies from 1985 to October 27, 2024. Original observational cases of GBFDE were included. Studies without quantitative patient data were excluded. We assessed study quality using the Newcastle-Ottawa scale, analyzed data descriptively, and performed comparative analyses. Of 347 publications reviewed, 83 studies composed of 430 cases were included, median age 56 years (interquartile range [IQR], 41-75 years). Common causative agents include nonsteroidal anti-inflammatory drugs (48.7%) available over the counter in many countries without prescription and antibiotics (30.9%). Median latency was 24 hours (IQR, 12-72 hours). Mucosal involvement occurred, but no cases involved ocular mucosa. Internal organ involvement was uncommon. Intensive care unit stay was required in 19.9%. Mortality was 15.2% and was significantly associated with age (P = .01). Median time to resolution was 11 days (IQR, 8-17 days). Post-inflammatory hyperpigmentation occurred in 54.3%. Corticosteroids were the most commonly used treatment (22.4% topical and 50.6% systemic). Data were heterogeneous, and the retrospective nature of reporting limited long-term outcome assessment. Generalized bullous fixed drug eruption has a short latency. Nonsteroidal anti-inflammatory drugs and antibiotics are the commonest triggers. Systemic dysfunction is less common than in Stevens-Johnson syndrome/toxic epidermal necrolysis, but morbidity and mortality is significant, particularly in elderly people. The widespread availability of over-the-counter NSAIDs may pose a risk for GBFDE.

#5

Doxycycline-induced fixed drug eruption: A case series highlighting a dermatological concern in antimicrobial stewardship.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2026 Mar

To describe a series of doxycycline-induced fixed drug eruptions (FDE) observed in sexual health clinics, in a context of increasing doxycycline use for sexually transmitted infection (STI) management and prophylaxis in France. We conducted a retrospective case series, combined with a doxycycline prescription audit and a sexual health clinician survey. Thirteen male patients (mean age: 32.5 years) were diagnosed with doxycycline-induced FDE. Most were MSM (men who have sex with men, 84.6%) and received doxycycline for STI treatment (92.3%). Lesions were mainly genital (85%) and often misdiagnosed as ulcerative STIs. Doxycycline prescriptions increased by 345% between 2018 and 2024. When performed, allergy workups confirmed the diagnosis in 60% of cases. The sharp rise in doxycycline use for STI prophylaxis coincides with the identification of multiple FDE cases. Enhanced dermatological awareness is needed within antimicrobial stewardship programs to ensure safer implementation of doxycycline-based prevention strategies.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC920 artigos no totalmostrando 197

2026

Minocycline-Induced Fixed Drug Eruption of the Lips.

Journal of cutaneous medicine and surgery
2026

First Reported Case of Treosulfan-Induced Fixed Drug Eruption.

American journal of therapeutics
2026

Wine-induced fixed drug eruption.

JAAD case reports
2026

Nimesulide-Associated Generalized Bullous Fixed Drug Eruption: A Rare Pharmacovigilance Case Report.

Cureus
2026

Fixed food eruption due to shellfish.

JAAD case reports
2026

Absence of Cross-Reactivity Between Ornidazole and Metronidazole in Fixed Drug Eruption Demonstrated by Lesional and Contralateral Patch Testing and Oral Provocation.

Contact dermatitis
2026

Internal organ involvement in epidermal necrolysis and bullous fixed drug eruption assessed by 18Fluorodeoxyglucose-positron emission tomography and computed tomography scan. A proof-of-concept study.

Clinical and experimental dermatology
2026

Fixed Drug Eruptions in Malagasy Children: Clinical Observations and Characteristics.

Case reports in dermatological medicine
2026

Fluconazole-Induced Fixed Drug Eruption With Cross-Reactivity to Clotrimazole-Confirmation With Patch Testing.

Case reports in dermatological medicine
2026

Generalized Bullous Fixed Drug Eruption: A Systematic Review.

The journal of allergy and clinical immunology. In practice
2025

Inclisiran-Induced Fixed Drug Eruption in a Patient With Refractory Hypercholesterolemia.

Cureus
2026

Doxycycline-induced fixed drug eruption: A case series highlighting a dermatological concern in antimicrobial stewardship.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2025

Bullous Fixed Drug Eruption Associated With Atenolol: A Rare Dermatological Reaction With Mucosal Involvement.

The American Journal of dermatopathology
2025

Etoricoxib-Induced Fixed Erythema.

Journal of clinical medicine
2025

Feasibility of gadolinium contrast use in transcatheter aortic valve implantation: a non-iodine-based procedure-case report.

European heart journal. Case reports
2025

Bullous fixed drug eruption associated with ibuprofen.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
2026

A Case of Generalized Fixed Drug Eruption Showing the Conjunctival Involvement With CD4+ Tissue-Resident Memory T Cell Accumulation.

The Journal of dermatology
2025

Fixed drug eruption induced by clarithromycin and paracetamol in a child.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
2025

Delayed hypersensitivity reaction to penicillin can be lost (and gained): Skin test resensitization following prolonged oral provocation test.

Asia Pacific allergy
2025

Multifocal bullous fixed-drug eruption caused by etodolac mimicking autoimmune bullous diseases: a case report.

European journal of dermatology : EJD
2026

Clues From Strange New Antigens: How Skin Responds to Nonself.

Laboratory investigation; a journal of technical methods and pathology
2025

Drug-induced fixed urticaria because of hypersensitivity to non steroidal anti-inflammatory drugs.

Allergologia et immunopathologia
2025

Skin-adverse drug reactions in the elderly: An underestimated and avoidable issue.

Annales de dermatologie et de venereologie
2025

Generalized Bullous Fixed Drug Eruption Secondary to Levocetirizine: A Lesson Learned!

Clinical case reports
2025

Generalized bullous fixed drug eruption related to intravenous contrast.

Dermatology online journal
2025

Allopurinol-Associated Bullous Fixed Drug Eruption With Cross-Reaction to Febuxostat.

American journal of therapeutics
2025

Fixed drug eruption misdiagnosed as herpes simplex virus infection.

Canadian family physician Medecin de famille canadien
2025

Generalized fixed drug eruptions in skin of color.

International journal of women's dermatology
2025

Localized bullous drug reaction to cefotaxime leading to wet gangrene in a neonate: A case report.

Journal of neonatal-perinatal medicine
2025

Bullous Non-Pigmenting Fixed Drug Eruption.

Deutsches Arzteblatt international
2025

Bullous Fixed Drug Eruption to Metformin Following a DRESS Syndrome to Allopurinol: What's the Link?

Dermatitis : contact, atopic, occupational, drug
2026

Clinical Characteristics of Adult Localized and Generalized Fixed Drug Eruptions: A Systematic Review.

International journal of dermatology
2025

Generalized Bullous Fixed Drug Eruption Induced by Chlordiazepoxide: A Case Report of a Potentially Lethal Adverse Effect.

Consortium psychiatricum
2025

The Use of Etanercept in the Palliative Treatment of a Patient With Generalised Bullous Fixed Drug Eruption.

The Australasian journal of dermatology
2025

Skin Testing for the Exploration of Immediate and Delayed Hypersensitivity to Fluoroquinolones: Insights From a Real-Life Cohort Study.

Dermatitis : contact, atopic, occupational, drug
2025

Fixed Drug Eruption With Isotopic Response.

The journal of allergy and clinical immunology. In practice
2025

A Fatal Case of Infection-Induced Neurofibromatosis Type 1 in an Adult.

Case reports in oncology
2025

A simple patch test (empty tablet cover patch test) demonstrating ornidazone as offending agent in a patient of fixed drug eruption: Report of a clinical case, a new modified technique and systematic review of literature.

Indian journal of pharmacology
2025

Association Between HLA-A*02:07 and Fixed Drug Eruption Caused by Sulfamethoxazole-Trimethoprim.

Materia socio-medica
2025

Fluoroquinolone-induced generalised fixed drug eruption: a rare clinical image.

The Pan African medical journal
2025

A case of recurrent fixed drug eruption triggered by a hormonal intrauterine device.

JAAD case reports
2025

Levofloxacin-Induced Generalized Fixed Drug Eruption.

Cureus
2024

Lichen planus pigmentosus inversus presenting with clinical features mimicking acanthosis nigricans.

Dermatology online journal
2025

Accelerated Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome in Response to TMP-SMX: A Case Report.

The American journal of case reports
2025

Adverse Cutaneous Reactions to Monoclonal Antibodies: Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis, Erythema Multiforme, and Fixed Drug Eruption - A Systematic Review.

Biomedicine hub
2025

Mental health and psychosocial outcomes in survivors of severe cutaneous adverse reactions: a scoping review.

Clinical and experimental dermatology
2025

Fixed drug eruption induced by Etoricoxib in Thailand: A case report.

Toxicology reports
2025

Cross-Reactivity: a Case of Paracetamol-Induced Generalized Bullous Fixed Drug Eruption Followed by Dipyrone-Induced Fixed Drug Eruption.

Clinical, cosmetic and investigational dermatology
2025

Fixed drug eruption in a cribriform pattern: an atypical presentation.

Skin health and disease
2025

Demographics, Overlap, and Latency of Severe Cutaneous Adverse Reactions in an FDA Database.

medRxiv : the preprint server for health sciences
2025

Tissue-resident memory T cells and their function in skin diseases.

Chinese medical journal
2025

Generalized bullous drug eruption triggered by ceftriaxone: a case report and literature overview.

Dermatology reports
2025

[Exanthematic drug eruption].

Pathologie (Heidelberg, Germany)
2024

Systematic review: characteristics of myocarditis followed by fixed drug eruption and dry eye syndrome in patients who have been vaccinated with monkeypox in children and adults.

Frontiers in cardiovascular medicine
2025

Intradermal Tranexamic Acid Injections: A Potential Therapy for Complex Cases of Drug-Induced Postinflammatory Hyperpigmentation.

Journal of cosmetic dermatology
2025

Vulval fixed drug eruption following trimethoprim use.

BMJ case reports
2025

Semaglutide-induced fixed drug eruption.

JAAD case reports
2024

Ibuprofen-Induced Multiple Fixed Drug Eruption Confirmed by Re-Challenge: A Case Report and Literature Review.

Diagnostics (Basel, Switzerland)
2025

Norfloxacin-Induced Penile Fixed Drug Eruption.

Journal of cutaneous medicine and surgery
2025

Fixed Drug Eruption due to Chlorpheniramine: Case Report.

Contact dermatitis
2024

Clinical cues for distinguishing bullous fixed drug eruption from Stevens-Johnson syndrome: A case report.

SAGE open medical case reports
2025

Fixed Drug Eruption-Induced Hyperpigmentation Treated With High-Fluence Picosecond Alexandrite Laser.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
2024

A review on toxic epidermal necrolysis-like superficial wound lesions: Issue and challenge on 10 clinical entities.

International wound journal
2025

Generalized bullous fixed drug eruption.

European journal of internal medicine
2024

Atypical Presentation of Rapidly Progressive Cutaneous Metastases of Clear Cell Renal Carcinoma: A Case Report.

Medicina (Kaunas, Lithuania)
2025

Caffeine-induced fixed drug eruption: evidence from a positive patch test.

The British journal of dermatology
2025

[Translated article] AEDV Expert Document on the Management of Ulcerative Venereal Infections.

Actas dermo-sifiliograficas
2024

Oral lichen planus-like lesions in skin of color: a review.

International journal of dermatology
2024

Chloroquine-Induced Fixed Drug Eruption: A Case Report.

Cureus
2025

Fixed drug eruption and generalized bullous fixed drug eruption: Insights from an analysis of the FDA Adverse Event Reporting System.

The journal of allergy and clinical immunology. In practice
2024

Fixed drug eruption due to ibuprofen.

Cleveland Clinic journal of medicine
2025

Generalized Fixed Drug Eruption Secondary to Etoricoxib.

Dermatitis : contact, atopic, occupational, drug
2024

Distinguishing Generalized Bullous Fixed Drug Eruption From SJS/TEN: A Retrospective Study on Clinical and Demographic Features.

Cutis
2024

Chlorzoxazone-Induced Fixed Drug Eruption: A Clinical Case Report.

International medical case reports journal
2024

Fixed Drug Eruption on the Penis Due to Trimethoprim-Sulfamethoxazole: A Case Report.

Cureus
2024

Generalized Fixed Drug Eruptions Require Urgent Care: A Case Series.

Cutis
2024

Pseudoephedrine-induced Fixed Drug Eruption in a Scuba Diver With Recurrent Palmoplantar Exfoliation.

Journal of preventive medicine and public health = Yebang Uihakhoe chi
2024

Lessons From Delayed Intradermal Testing: A Case of Fixed Drug Eruption From Intra-Articular Methylprednisolone.

The journal of allergy and clinical immunology. In practice
2025

Doxycycline-induced fixed drug eruption: The new epidemic?

Journal of the European Academy of Dermatology and Venereology : JEADV
2025

Fixed drug eruption mimicking syphilitic balanitis of Follmann.

Infection
2024

Fixed Drug Eruption to Levocetirizine Detected by Patch Testing.

Indian dermatology online journal
2024

Delayed Skin Testing for Systemic Medications: Helpful or Not?

The journal of allergy and clinical immunology. In practice
2024

A case of fixed drug eruption caused by allylisopropylacetylurea and bromovalerylurea in the same lesion.

Contact dermatitis
2024

Fixed drug eruption secondary to etoricoxib.

The British journal of oral &amp; maxillofacial surgery
2024

Doxycycline prophylaxis and meningococcal group B vaccine to prevent bacterial sexually transmitted infections in France (ANRS 174 DOXYVAC): a multicentre, open-label, randomised trial with a 2 × 2 factorial design.

The Lancet. Infectious diseases
2024

Severe cutaneous adverse reactions.

Nature reviews. Disease primers
2024

Fixed Drug Eruption due to Dupilumab.

Acta dermato-venereologica
2024

Trips Through the Skin: Reviewing Cutaneous Drug Reactions to Psychedelics and Hallucinogens.

Dermatitis : contact, atopic, occupational, drug
2024

A Clinico-Epidemiological Study of Cutaneous Adverse Drug Reactions in a Tertiary Care Centre of Eastern India.

Indian journal of dermatology
2024

Fixed drug eruption due to tipepidine hibenzate and garenoxacin mesylate hydrate: an unusual case of polysensitivity.

European journal of dermatology : EJD
2024

A Clinico-Epidemiological Study of Fixed Drug Eruption with a Special Focus on the Causative Agent and the Clinical Patterns.

Indian dermatology online journal
2024

Nimesulide-Induced Fixed Drug Eruption Followed by Etoricoxib-Induced Fixed Drug Eruption: An Unusual Case Report and Review of the Literature.

Journal of clinical medicine
2024

A Saudi Woman with Ceftriaxone Induced Fixed Drug Eruption.

Case reports in dermatological medicine
2024

Erythema Multiforme-Like Fixed Drug Eruption During Azathioprine and Hydroxychloroquine Treatment for Systemic Lupus Erythematosus Mimicking Rowell Syndrome: A Rare and Challenging Clinical Scenario.

International journal of surgical pathology
2024

Multiple widespread fixed drug eruption caused by in a transdermal therapeutic system.

Contact dermatitis
2024

Analysis of Cutaneous Adverse Drug Reactions (ADR) Reported at an ADR Monitoring Center of a Tertiary Care Teaching Institute in Central India.

Cureus
2024

Anaphylactic Shock After Intramuscular Diclofenac Sodium: A Case Report.

Cureus
2024

Cefepime-Induced Generalized Fixed Drug Eruption With Morbilliform Rash.

Cureus
2023

Dose-dependent, non-pigmenting fixed drug eruption with eczematous lesions induced by bosutinib: case report.

The Pan African medical journal
2024

A case of bullous fixed drug eruption caused by tadalafil.

JAAD case reports
2024

Genital Ulcers Are Not Always Because of Sexually Transmitted Infections: A Case Report of an Unusual Presentation of Fixed Drug Eruption in a Pediatric Patient.

Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates &amp; Practitioners
2024

Triggers, clinical manifestations and assessment of paediatric fixed drug eruptions: A systematic review of the literature.

Contact dermatitis
2023

Paracetamol-induced generalized fixed-drug eruption with localized bullous variant in a 15-year-old boy.

Indian journal of pharmacology
2024

Patch test with multiple antipyretics in a case of fixed drug eruption in a child.

Contact dermatitis
2024

Fixed drug eruption-induced balanoposthitis: a case report.

International journal of impotence research
2024

Bullous fixed drug eruption due to ivermectin.

The American journal of the medical sciences
2023

Fixed Drug Eruption Caused by Garenoxacin: A Case Report and Literature Review.

Cureus
2023

Recurrent Fluconazole-Induced Fixed Drug Eruption of the Digit with Nail Matrix Involvement: A Case Report and Review of the Literature.

Skin appendage disorders
2023

Mucosal Fixed Drug Eruption with Oral, Conjunctival, Nasal, and Anal Lesions: A Case Report.

Acta dermato-venereologica
2024

Fixed drug eruption caused by iodinated contrast media: An unusual hypersensitivity reaction.

Contact dermatitis
2022

Azithromycin-Induced Generalized Nonbullous Fixed-Drug Eruption.

Journal of research in pharmacy practice
2024

A case of nonpigmented fixed-drug eruption with eosinophilic intraepidermal vesicle formation.

The Journal of dermatology
2024

Drug eruptions and the vulva.

Clinical and experimental dermatology
2024

Ofloxacin-Induced Genital Bullous Fixed Drug Eruption: A Rare Case of Cross-Reactivity to Multiple Fluoroquinolones.

Dermatitis : contact, atopic, occupational, drug
2023

Chlorthalidone-Induced Fixed-Drug Eruption: Unmasking an Uncommon Reaction to a Common Diuretic.

Cureus
2024

In Situ Patch Test and Repeated Open Application Test for Fixed Drug Eruption: A Multicenter Study.

The journal of allergy and clinical immunology. In practice
2023

Fixed Drug Eruption in a Patient Taking Valacyclovir without Cross-Reactivity to Acyclovir.

Annals of dermatology
2024

Reflectance confocal microscopy as a complementary diagnostic tool for greyish-brown dermatoses in children.

Clinical and experimental dermatology
2024

Carbamazepine-induced bullous fixed drug eruption: A case report.

Therapie
2023

Genotypic and Phenotypic Characteristics of Co-Trimoxazole-Induced Cutaneous Adverse Reactions.

Dermatology (Basel, Switzerland)
2023

Fixed drug eruption - Experience from a tertiary care center in Uttarakhand.

Indian journal of pharmacology
2023

Fixed Drug Eruptions With Flavoured Liquid Formulations of Over-the-Counter Analgesics: A Case Report.

Cureus
2023

Erythematous-violaceous and bullous skin lesions after administration of iodinated contrast in a patient on hemodialysis. A case of fixed drug eruption due to iodinated contrast.

Nefrologia
2024

IFN-γ ELISpot-enabled machine learning for culprit drug identification in nonimmediate drug hypersensitivity.

The Journal of allergy and clinical immunology
2023

Case report: Generalized bullous fixed drug eruption mimicking epidermal necrolysis.

Frontiers in medicine
2024

Patch Testing to the Rescue! Lesional Testing for Diagnosis of Fixed Drug Eruption to Pamabrom.

Dermatitis : contact, atopic, occupational, drug
2023

Neutrophilic fixed drug eruption, a histopathologic variant or an expected finding?-A report of two cases and review of the literature.

Journal of cutaneous pathology
2023

Tadalafil-Induced Generalized Bullous Fixed Drug Eruption: A Rare Side Effect of a Common Drug.

Cureus
2024

Metronidazole Induced Cutaneous Adverse Drug Reaction- A Systematic Review of Descriptive Studies.

Current reviews in clinical and experimental pharmacology
2023

Generalised bullous fixed drug eruption induced by a topical plaster with Chinese herbs.

Contact dermatitis
2023

Long-term HIV and tuberculosis outcomes in patients hospitalised with severe cutaneous adverse reactions.

Journal of clinical tuberculosis and other mycobacterial diseases
2023

A Study of Cutaneous Adverse Drug Reactions at a Tertiary Care Center in Andhra Pradesh, India.

Cureus
2023

Rapidly progressing generalized bullous fixed drug eruption after the first dose of COVID-19 messenger RNA vaccination.

The Journal of dermatology
2023

Photobiomodulation Therapy for Multiple Painful Fixed Drug Eruptions: The First Case Report.

Journal of lasers in medical sciences
2023

MULTIFOCAL FIXED DRUG ERUPTION MIMICKING ACQUIRED DERMAL MELANOCYTOSIS.

Georgian medical news
2023

Metformin-Induced Generalized Bullous Fixed-Drug Eruption with a Positive Dechallenge-Rechallenge Test: A Case Report and Literature Review.

Case reports in dermatological medicine
2023

A Fixed-Dose Combination of Ofloxacin-Ornidazole Induced Fixed Drug Eruption: A Case Report.

Cureus
2022

Nicorandil-Induced Bullous Fixed Drug Eruption on the Glans Penis.

Indian journal of dermatology
2023

Successful treatment of hyperpigmentation from fixed drug eruption with a low-dose and large-spot Q-switched 1064 nm Nd:YAG Laser.

Journal of cosmetic dermatology
2023

Fixed drug eruption: the often forgotten cutaneous adverse drug reaction.

The Medical journal of Australia
2023

Delayed Drug Hypersensitivity Reactions: Molecular Recognition, Genetic Susceptibility, and Immune Mediators.

Biomedicines
2023

An Observational Study of Fixed Drug Eruption in A Tertiary Care Hospital in Bangladesh.

Mymensingh medical journal : MMJ
2023

Novel cutaneous eruptions in the setting of programmed cell death protein 1 inhibitor therapy.

JAAD case reports
2023

Possible Plasticity of Cytotoxic Resident Memory T Cells in Fixed Drug Eruption.

The Journal of investigative dermatology
2023

A case of fixed drug eruption from cetirizine with cross-reaction to levocetirizine and hydroxyzine.

Contact dermatitis
2023

Fixed drug eruption to aripiprazole, cetirizine, and hydroxyzine hydrochloride.

Annals of allergy, asthma &amp; immunology : official publication of the American College of Allergy, Asthma, &amp; Immunology
2022

Generalized fixed drug eruption following Pfizer-BioNtech COVID-19 vaccination.

Clinical case reports
2022

Case report: Severe non-pigmenting fixed drug eruption showing general symptoms caused by chondroitin sulfate sodium.

Frontiers in medicine
2023

Uncommon variants of fixed drug eruption.

Indian journal of dermatology, venereology and leprology
2023

Cutaneous adverse drug eruption: the role of drug patch testing.

International journal of dermatology
2023

Cross-reactivity between nonsteroidal anti-inflammatory drugs in fixed drug eruption: Two unusual cases and a literature review.

British journal of clinical pharmacology
2022

Fixed drug eruptions - the common and novel culprits since 2000.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
2022

Hypopigmented penile fixed drug eruption.

Clinical case reports
2022

Nicotine-induced bullous fixed drug eruption.

JAAD case reports
2023

A case of recurrent fixed drug eruption following the administration of 2 different coronavirus disease 2019 vaccines verified using intradermal and patch tests.

JAAD case reports
2022

Fixed Drug Eruption: An Underrecognized Cutaneous Manifestation of a Drug Reaction in the Primary Care Setting.

Cureus
2022

Study protocol: Australasian Registry of Severe Cutaneous Adverse Reactions (AUS-SCAR).

BMJ open
2024

Drugs and the skin: A concise review of cutaneous adverse drug reactions.

British journal of clinical pharmacology
2022

Sulphamethoxazole-trimethoprim induced fixed drug eruption in a patient with Chronic Granulomatous Disease.

Qatar medical journal
2022

Severe cutaneous adverse reactions: A 5-year retrospective study at Hospital Melaka, Malaysia, from December 2014 to February 2020.

The Medical journal of Malaysia
2022

Generalized Bullous Fixed Drug Eruption to Iodinated Contrast Media in Skin of Color.

The American journal of medicine
2022

Annular lichenoid eruption following treatment with casirivimab/imdevimab for COVID-19.

JAAD case reports
2022

Common pitfalls and bias learned from the COVID-19 pandemic: Keeping a clear mind of judgment.

JAAD case reports
2022

Fixed drug eruption after the Sinopharm COVID-19 vaccine.

JEADV clinical practice
2022

A Fixed Drug Eruption to Medroxyprogesterone Acetate Injectable Suspension.

Cutis
2022

A case of paracetamol-induced nonpigmented fixed drug eruption confirmed by a lymphocyte transformation test.

European journal of dermatology : EJD
2022

Reprint of: Fixed-Drug-Eruption associated with NSAID exposure.

Disease-a-month : DM
2022

Severe Cutaneous Adverse Drug Reactions in Children: Epidemiological, Clinical and Etiological Aspects in Dermatology-Venereology Unit at National and Teaching Hospital of Cotonou.

West African journal of medicine
2022

Fixed drug eruption due to clindamycin with tolerance to lincomycin.

Contact dermatitis
2022

Fixed drug eruption from atezolizumab.

Dermatology online journal
2022

Fixed drug eruption after Pfizer-BioNTech COVID-19 vaccine: A case report.

The journal of allergy and clinical immunology. In practice
2022

Ecstasy-induced fixed drug eruption.

Contact dermatitis
2022

Oral fixed drug eruption: Analyses of reported cases in the literature.

Journal of stomatology, oral and maxillofacial surgery
2022

Angioedema and fixed drug eruption simultaneously induced by naproxen sodium: A rare clinical entity.

Journal of cosmetic dermatology
2022

Another case of generalized bullous fixed drug eruption following an adenoviral vector-based COVID-19 vaccine (ChAdOx1 nCov-19).

Journal of the European Academy of Dermatology and Venereology : JEADV
2023

Multifocal Bullous Fixed Drug Eruption.

Acta medica portuguesa
2022

Fixed Drug Eruption Associated with Nonsteroidal Anti-Inflammatory Drugs for Menstrual Pain: A Case Report.

Case reports in dermatology
2022

A Case of Mucosal Fixed Drug Eruption Caused by Tamsulosin Administration.

Annals of dermatology
2022

Mucosal fixed drug eruption to levetiracetam with early positive patch test on non-lesional skin.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
2022

Fixed drug eruption in a patient of HLA-B*58:01 negative after allopurinol administration: A case report.

Journal of clinical pharmacy and therapeutics
2022

The Role of Patch Testing in Evaluating Delayed Hypersensitivity Reactions to Medications.

Clinical reviews in allergy &amp; immunology
2022

Neutrophils in Fixed Drug Eruptions: Correction of a Mistaken Hypothesis.

The American Journal of dermatopathology
2021

Cutaneous Adverse Drug Reactions in a Tertiary Teaching Hospital: A Prospective, Observational Study.

Indian journal of dermatology
2023

Bizarre Cutaneous Ulcers due to Self-Administered Intravenous Dexketoprofen Trometamol.

The international journal of lower extremity wounds
2022

Annular lichenoid diseases.

Clinics in dermatology
2022

Immediate and Delayed Hypersensitivity Reactions to Antibiotics: Aminoglycosides, Clindamycin, Linezolid, and Metronidazole.

Clinical reviews in allergy &amp; immunology
2021

The Initial Stage of Neutrophilic Dermatosis of the Dorsal Hands: A Case Report and Discussion of Differential Diagnoses.

The Journal of clinical and aesthetic dermatology
2021

Fixed Drug Eruption Secondary to Four Anti-diabetic Medications: An Unusual Case of Polysensitivity.

Cureus
2021

A Study of Cutaneous Adverse Drug Reactions and their Association with Autoimmune Diseases at a Tertiary Centre in South-West Rajasthan, India.

Indian journal of dermatology
2021

Bullous Erythema Multiforme Secondary to Trimethoprim-Sulfamethoxazole Use, Treated With Cyclosporine in a 91-Year-Old Male.

Cureus
2021

Hyperpigmentation From Fixed Drug Eruption Successfully Treated With a Low-Fluence 1064 nm Nd:YAG Picosecond Laser.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
2022

Analysis of severe cutaneous adverse reactions (SCARs) in Taiwan drug-injury relief system: 18-year results.

Journal of the Formosan Medical Association = Taiwan yi zhi
2022

Patch testing versus interferon-gamma release assay in evaluation of drug eruptions.

Fundamental &amp; clinical pharmacology
2022

Multiple fixed drug eruption due to carbocysteine: Presence of circulating interferon-γ-producing CD8+ T cells reactive with its night metabolite thiodiglycolic acid.

Allergology international : official journal of the Japanese Society of Allergology
2022

Vulvar and areolar fixed drug eruption.

American journal of obstetrics and gynecology
2021

A Review of Fixed Drug Eruption with a Special Focus on Generalized Bullous Fixed Drug Eruption.

Medicina (Kaunas, Lithuania)
2021

Skin Resident Memory T Cells May Play Critical Role in Delayed-Type Drug Hypersensitivity Reactions.

Frontiers in immunology
Ver todos os 920 no EuropePMC

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Comunidades

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Nimesulide-Associated Generalized Bullous Fixed Drug Eruption: A Rare Pharmacovigilance Case Report.
    Cureus· 2026· PMID 41685037mais citado
  2. Fixed Drug Eruptions in Malagasy Children: Clinical Observations and Characteristics.
    Case reports in dermatological medicine· 2026· PMID 41626534mais citado
  3. Fluconazole-Induced Fixed Drug Eruption With Cross-Reactivity to Clotrimazole-Confirmation With Patch Testing.
    Case reports in dermatological medicine· 2026· PMID 41613630mais citado
  4. Generalized Bullous Fixed Drug Eruption: A Systematic Review.
    The journal of allergy and clinical immunology. In practice· 2026· PMID 41539429mais citado
  5. Doxycycline-induced fixed drug eruption: A case series highlighting a dermatological concern in antimicrobial stewardship.
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases· 2026· PMID 41429253mais citado
  6. Fixed drug eruption induced by mycophenolate mofetil, a rare entity with significant consequences.
    Br J Clin Pharmacol· 2026· PMID 41967866recente
  7. Cutaneous adverse drug reactions: A prospective observational study at a tertiary care hospital in Central India.
    Bioinformation· 2025· PMID 41907933recente
  8. Fixed Drug Eruption Following Concurrent Ciprofloxacin and Metronidazole Therapy: A Dermoscopy-Assisted Diagnosis.
    Cureus· 2026· PMID 41890473recente
  9. Minocycline-Induced Fixed Drug Eruption of the Lips.
    J Cutan Med Surg· 2026· PMID 41830207recente
  10. First Reported Case of Treosulfan-Induced Fixed Drug Eruption.
    Am J Ther· 2026· PMID 41714900recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:293812(Orphanet)
  2. MONDO:0017395(MONDO)
  3. GARD:21170(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Q719727(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Eritema pigmentado fixo
Compêndio · Raras BR

Eritema pigmentado fixo

ORPHA:293812 · MONDO:0017395
Prevalência
Unknown
Herança
Not applicable
CID-10
L25.1 · Dermatite de contato não especificada devida a drogas em contato com a pele
CID-11
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0877391
EuropePMC
Wikidata
Papers 10a
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