Febre do vale Rift

Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective

NCT07358910

RECRUTANDO

Phase 2 Safety and Immunogenicity Study of Rift Valley Fever Vaccine

NCT03609398

RECRUTANDO

Study to Evaluate Safety, Tolerability and Pharmacokinetics of IDB-011

NCT06925919

EM ANDAMENTO

Safety and Immunogenicity of a Candidate Rift Valley Fever Vaccine (RVF003)

NCT06799234

EM ANDAMENTO

Safety and Immunogenicity of a Candidate RVFV Vaccine (RVF001)

NCT04754776

CONCLUÍDO

🟢 Recrutando agora

2 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

NCT07358910 · Risk Assessment of Community Spread of Multiple Endemic Infe…Recrutando

NCT03609398 · Phase 2 Safety and Immunogenicity Study of Rift Valley Fever…Recrutando

NCT06925919 · Study to Evaluate Safety, Tolerability and Pharmacokinetics …Ativo

Outros ensaios clínicos

11 ensaios clínicos encontrados, 4 ativos.

Distribuição por fase

PHASE1

NCT06799234 · Safety and Immunogenicity of a Candidate Rift Valley Fever V…Ativo

NCT04754776 · Safety and Immunogenicity of a Candidate RVFV Vaccine (RVF00…Concluído

EARLY_PHASE1

NCT04672824 · A Study to Assess the New Candidate Rift Valley Fever Virus …Concluído

PHASE1

NCT00869713 · Safety and Immunogenicity Study of Rift Valley Fever Vaccine…Concluído

NCT05139524 · RVF and Other Emerging Infectious Diseases in East and Centr…UNKNOWN

NCT00584194 · Safety and Immunogenicity Study of Rift Valley Fever VaccineConcluído

NCT00415051 · Safety/Immunogenicity/Genetic Drift of MP-12 Rift Valley Fev…Concluído

NCT00287014 · Rift Valley Fever in KenyaConcluído

Ver todos no ClinicalTrials.gov

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Publicações mais relevantes

Timeline de publicações

1.370 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 1.370

#1

Live-cell 3D-SIM of Rift Valley fever virus NSs filaments reveals a polygon web architecture.

Proceedings of the National Academy of Sciences of the United States of America2026 Mar 24

A defining feature of Rift Valley fever virus (RVFV) is the incorporation of the NSs protein into large filamentous assemblies inside infected nuclei [R. Swanepoel, N. K. Blackburn, J. Gen. Virol. 34, 557-561 (1977).], as judged from fixed specimens. To gain insight into the 3D structure of NSs filaments within live-cell nuclei, we used genetic-code expansion (GCE) to incorporate trans-cyclooct-2-en-L-lysine into the protein. This enabled site-specific fluorescent labeling with tetrazine dyes for live-cell structured illumination microscopy (SIM). Our superresolved images revealed the complete native architecture of NSs filaments as a micron-scale polygon web of fibers with discrete domain characteristics, overturning previous assumptions of simple linear filaments. Parallel experiments on fixed RVFV-infected cells confirmed that native NSs filaments also display this morphology. Overall, our 3D-SIM analysis reveals distinct structural plasticity within NSs filaments, establishing a quantitative structure-function relationship that support the importance of polygon organization for NSs filament function during RVFV infection.

#2

Dose-dependent immune modulation in arboviral coinfections among febrile patients.

Frontiers in cellular and infection microbiology2026

Arboviruses pose substantial diagnostic and public health challenges in tropical regions where multiple pathogens co-circulate. Nigeria, with diverse ecological zones and limited surveillance infrastructure, represents a critical nexus for arboviral transmission, yet comprehensive data on seroprevalence, coinfection dynamics, immune modulation, and viral genetic diversity remain scarce. We conducted cross-sectional surveillance across three Nigerian ecological zones from January 2019 to December 2023. Sera from 871 participants were tested for IgG and IgM antibodies to dengue virus (DENV), chikungunya virus (CHIKV), Zika virus (ZIKV), yellow fever virus (YFV), West Nile virus (WNV), and Rift Valley fever virus (RVFV) using immunoblot assays. A stratified subset (n=300) underwent cytokine profiling for interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), and interleukin-10 (IL-10). IgM-positive samples underwent RT-PCR confirmation with genotype assignment through sequence comparison against GenBank reference strains. Overall IgM seropositivity indicating recent infection was 86.8% (756/871), with DENV most prevalent (59.6%; 95% CI: 56.3-62.8%), followed by CHIKV (49.4%), YFV (48.3%), ZIKV (19.7%), WNV (3.4%), and RVFV (2.3%). Coinfection with two or more arboviruses was detected in 61.2% (533/871) of participants. Seropositivity was highest in the tropical rainforest zone (94.2%) compared with Guinea savanna (84.5%) and Sudan savanna (80.4%; χ²=31.8, p<0.001). Cytokine profiling revealed significantly elevated concentrations of IL-6, TNF-α, IFN-γ, and IL-10 in dual and triple infections compared with mono-infections (all p<0.001), demonstrating dose-dependent immune modulation. All four DENV serotypes were identified, with DENV-2 predominating (59.9%). Molecular characterisation confirmed circulation of CHIKV East/Central/South African genotype (82.1%), DENV-2 Cosmopolitan genotype, and both African (71.2%) and Asian (28.8%) ZIKV lineages, with study sequences showing >99% nucleotide identity to established reference strains. These findings reveal extraordinarily high levels of arboviral infection and coinfection across Nigerian ecological zones. The dose-dependent cytokine elevation in coinfections suggests distinct immunopathological mechanisms. These data underscore the urgent need for multiplex diagnostics, genotype-specific monitoring, and climate-informed vector control strategies.

#3

Understanding the Rift Valley fever exposure risk: A comparative perspective from a multi-country study in East and Central Africa, 2021-24.

PLoS neglected tropical diseases2026 Mar

Rift Valley fever (RVF) is a concern in East and Central Africa, particularly following periods of heavy rainfall and flooding. However no human outbreaks have been reported in the Democratic Republic of the Congo (DRC). To assess whether this reflects a true absence of virus circulation, we estimated RVF seroprevalence in Goma (eastern DRC) and examined context-specific risk factors, comparing the findings with data from outbreak-prone countries. A two-year longitudinal study, across six health facilities in DRC, Kenya and Uganda, enrolled febrile subjects aged ≥10 years. Human serum samples were analyzed for RVF virus and anti-RVF antibodies. Demographic, behavioral, occupational and environmental factors were evaluated. 4,806 participants were enrolled: 1,370 (28.5%) DRC, 1,468 (30.6%) Kenya and 1,968 (40.9%) Uganda. 253 participants (5.3%) tested positive for RVF by serological and/or molecular assays: 19 (1.4%) DRC, 29 (2.0%) Kenya and 205 (10.4%) Uganda (p < 0.001). Only in Uganda, subjects tested positive for RVF virus by PCR (10 subjects, 0.5%). Occupations and activities involving contact with livestock, predominated in Kenya and Uganda, whereas handling of raw meat was most common in DRC. No specific occupations or activities were significantly associated with RVF exposure in DRC while several significant factors were identified for Kenya and Uganda. Multivariate analysis across all three countries showed that being from Uganda, male, over 20 years of age, employed as butcher or crop farmer and engaging in animal-related activities, were independently associated with RVF positivity, as was contact with sheep. Despite a prevailing sense that RVF transmission does not occur in DRC, we found a seroprevalence of 1.4%, comparable to Kenya where RVF is well documented. Further research targeting high-risk human and animal populations in DRC is warranted. A One Health approach will contribute to defining the ecology of local transmission of RVF in DRC.

#4

Biosensors for the detection of arthropod-borne veterinary viruses: A comprehensive review.

Veterinary and animal science2026 Jun

Veterinary arboviruses pose serious threats to animal health, especially in endemic areas. Traditional methods used for the diagnosis of these viruses are expensive, time-consuming, and require specialized personnel. This review discusses biosensor technologies for veterinary arboviruses, analyzing specific targets, mechanisms, sensitivity, specificity, and utility for use in the field. The remaining gaps were also mentioned. A comprehensive literature search was carried out in the major databases from 2015 to 2025. We used the keywords "Biosensing Technologies"Arboviruses," "Veterinary Medicine," "Viral Diseases," and "Point-of-Care Systems," and names of veterinary arbovirus families and their viruses. The findings reveal that biosensors have shown great sensitivity, specificity, and fast detection for various veterinary arbovirus families in the field. The technologies used were electrochemical, optical, CRISPR-based, and microfluidic formats, which are often improved by the use of nanomaterials and smartphone integration. The platforms directed against Japanese encephalitis, Rift Valley fever, and African swine fever had the lowest detection limits of femtomolar and also had the capability for multiplexing. Nevertheless, the technological development of biosensors remains restricted to a few viruses only, thus revealing substantial veterinary diagnostic gaps. Overall, biosensors have great potential in veterinary virology, with the capability of early diagnosis and, consequently, better outbreak response. Many of these sensors are specific, sensitive, and portable, making them great options for point-of-care applications. Future attention should be given to less-studied viruses, large-scale field validation, and multitarget biosensing platforms to improve veterinary surveillance globally.

#5

Spatiotemporal patterns of Rift Valley fever virus in Africa: a retrospective genomic epidemiology and phylodynamic modelling study.

The Lancet. Microbe2026 Mar

Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic pathogen causing outbreaks in humans and ruminants across Africa and the Arabian Peninsula. Originally restricted to the Great Rift Valley, RVFV has expanded geographically, prompting its classification by WHO as a pathogen of pandemic potential. We investigated the evolutionary and spatial dynamics of RVFV across Africa. We used genomic data generated at the International Livestock Research Institute Nairobi genomic laboratory (BioProject PRJNA1106221) and combined with publicly available datasets retrieved from the National Center for Biotechnology (NCBI) GenBank nucleotide database. In retrieving RVFV genome sequences from the NCBI GenBank, we applied the search terms "Rift Valley fever virus segment L AND 6404[SLEN]", "Rift Valley fever virus segment M AND 3885[SLEN]", and "Rift Valley fever virus segment S AND 1520:1690[SLEN]" for L (Large), M (Medium), and S (Small) segments, respectively. For sequences without additional spatiotemporal information, we searched PubMed to extract the associated sequence metadata. We performed molecular clock analysis, phylogenetic inference, phylodynamic modelling (continuous phylogeographic reconstruction), and landscape phylogeography on the three RVFV genome segments (L, M, and S). We aimed to assess evolutionary rates, dispersal patterns, and environmental drivers. Focus was placed on lineage C, the most widely distributed variant. The global dataset used in this study consisted of large (n=236), medium (n=237), and small (n=247), which were further filtered to exclude potential reassortants and vaccine strains. Genome sequences retrieved from NCBI GenBank database comprised large (n=180), medium (n=184), and small (n=202). The genome sequences from retrospective human and livestock isolates comprised large (n=56), medium (n=53), and small (n=45) collected in Burundi (2018), Kenya (2007, 2018, 2019, 2021, and 2022), and Rwanda (2018 and 2022). Our dataset revealed that RVFV exhibited low overall genetic diversity. Lineage C, however, showed evidence of active evolution, with substitution rates ranging from 3·58 × 10-4 to 9·76 × 10-4 substitutions per site per year. This lineage probably originated in Zimbabwe in the mid-1970s and has since expanded across eastern and southern Africa. Phylogeographic reconstructions revealed rapid spread, with diffusion coefficients exceeding 50 000 km2 per year. Lineage C appears capable of establishing endemic transmission in new regions, with ongoing diversification observed during interepidemic periods. These observations reinforce the value of continuous genomic surveillance, particularly during cryptic transmission phases when adaptive mutations might emerge. Although further evidence is needed, observed trends in climate variability and land-use change point to the potential benefit of targeted surveillance in settings that could be at increased risk, including urban centres and wetlands. This work was supported by the German Federal Ministry for Economic Cooperation and Development, the Rockefeller Foundation, and the Africa Centres for Disease Control and Prevention.

Publicações recentes

Systematic review and meta-analysis for the occurrence of Crimean-Congo hemorrhagic fever, Tularemia, and Rift Valley fever in pastoralist systems in Africa.

Front Vet Sci2025

Infectious Agents of Non-Malarial Febrile Illnesses in 20 African Countries, 2019-2024: A Systematic Review and Meta-Analysis.

Trop Med Int Health2026 Apr 15

Sensitivity analysis of factors influencing the ecology of mosquitoes involved in the transmission of Rift Valley fever virus.

PLoS Negl Trop Dis2026 Apr 13

Epidemiological and molecular characterization of Rift Valley fever outbreak in livestock in Burundi, May - November 2022.

PLoS Negl Trop Dis2026 Apr

The RNA helicase eIF4A as a novel target in insect cells to combat arboviral infections.

PLoS One2026

Ver todas no PubMed

📚 EuropePMC1.955 artigos no totalmostrando 198

Ferritin nanoparticles displaying rift valley fever virus glycoprotein elicit potent dendritic cell activation in vitro.

Unreported Rift Valley fever virus circulation during 2023-2024 El Niño event detected by slaughterhouse-based surveillance in southern Kenya.

Diagnostic microbiology and infectious disease

Accuracy of rapid and near-patient diagnostics for detection of rift valley fever and Crimean-Congo haemorrhagic Fever infections: A systematic review and meta-analysis.

Memorias do Instituto Oswaldo Cruz

Investigation of neurotropic arboviruses in wild and domestic animals in Amazon region, 2023-2024.

Proceedings of the National Academy of Sciences of the United States of America

Live-cell 3D-SIM of Rift Valley fever virus NSs filaments reveals a polygon web architecture.

Development of reference material from Rift Valley fever virus RNA.

Journal of public health in Africa

Prioritisation and risk ranking of epidemic-prone diseases for emergency preparedness and response in Eastern Africa using a multi-criteria decision analysis framework, 2023.

Frontiers in cellular and infection microbiology

Dose-dependent immune modulation in arboviral coinfections among febrile patients.

Understanding the Rift Valley fever exposure risk: A comparative perspective from a multi-country study in East and Central Africa, 2021-24.

Induction of a Th1-Type Polyfunctional T Cell Response by the four-segmented Rift Valley Fever candidate vaccine in humans.

Veterinary and animal science

Biosensors for the detection of arthropod-borne veterinary viruses: A comprehensive review.

ACS applied materials & interfaces

Magneto-Plasmonics-Enhanced Colorimetric Lateral Flow Immunoassay Using Magnetic-Gold Nanostars.

Medecine tropicale et sante internationale

[Mosquito-borne diseases in the Republic of Djibouti: a review of the literature].

Transboundary and emerging diseases

Transboundary Animal Diseases Associated With Cross-Border Camel Movement. A Systematic Review and Meta-Analysis.

Rift Valley fever virus dynamics in a transhumant cattle system in The Gambia.

eLife

Durable protection against lethal Rift Valley fever hepatitis and encephalitis following low-dose ΔNSsΔNSm vaccination in mice.

mSphere

A Cross-Sectional Study of Rift Valley Fever Exposure in Humans and Livestock in Southwestern Uganda Using a One Health Approach: Evidence of Elevated Seroprevalence Outside Recognized Outbreak Periods.

Current research in parasitology & vector-borne diseases

A systematic review and meta-analysis of mosquito arboviral infections detected through xenosurveillance in Africa: A focus on West Nile, Rift Valley fever, and chikungunya virus infections.

Spatiotemporal patterns of Rift Valley fever virus in Africa: a retrospective genomic epidemiology and phylodynamic modelling study.

The Lancet. Microbe

(Sero)prevalence of (re)emerging major arbovirus infections in Africa: a systematic review and meta-analysis protocol.

Systematic reviews

Structural basis for recognition of Rift Valley fever virus Gn protein by a human neutralizing monoclonal antibody with a kappa light chain.

PLoS pathogens

Efficient sensing of a four-segmented Rift Valley fever virus vaccine candidate by human monocytes.

Microbial pigments as potential anti-rift valley fever virus drugs.

BMC chemistry

Emerging microbes & infections

Potent neutralization of Rift Valley fever virus mediated by monoclonal antibodies via concurrent inhibition of attachment and fusion.

Seroprevalence of rift valley fever virus and associated risk factors in small ruminants at human-livestock-wildlife interface within Uganda's conservation areas.

BMC veterinary research

Entropy-based analysis of Rift Valley fever transmission dynamics using delay differential equations.

Investigation and response to rift valley fever outbreak in ruminant livestock from Ngoma District, eastern province of Rwanda, 2024.

Altered histone modifications in Aedes aegypti midguts following Rift Valley fever virus exposure.

Frontiers in public health

Prevalence and associated factors of human haemorrhagic fevers in Senegal: a comprehensive analysis of Hantaan, Crimean-Congo haemorrhagic fever and Rift Valley fever.

LRP1 Interacts with the Rift Valley Fever Virus Glycoprotein Gn via a Calcium-Dependent Multivalent Electrostatic Mechanism.

Biomolecules

Tropical medicine and health

Human and livestock exposure to Rift Valley fever virus and Coxiella burnetii in Eastern Ethiopia: a One Health cross-sectional study.

Proceedings. Biological sciences

Interepidemic Rift Valley fever in East Africa: the recent risk landscape and projected impacts of global change.

Rift Valley fever virus activates multiple cell death pathways in neurons.

Investigating the Sudan virus outbreak in Uganda through the deployment of a mobile laboratory.

Molecular diagnosis of arboviruses (dengue, Chikungunya, yellow fever, Rift Valley fever, Mayaro, West Nile, and Zika viruses) in non-malaria acute febrile illnesses in Kenya's Garissa County, July 2023, and Mombasa County, July 2024.

Attenuated viral strains of priority pathogens for potential use in controlled human infection model studies: A scoping review.

Seroprevalence of Crimean-Congo Hemorrhagic Fever and Rift Valley Fever Viruses Among Ruminants in Nigeria: A Descriptive Epizootiological Analysis.

Emerging microbes & infections

Differential innate immune activation by wild-type and NSs-deficient RVFV strains in human blood monocytes.

Seroprevalence of Akabane, border, and Rift Valley fever diseases and their risk factors in small ruminants of Fars Province, Southern Iran.

ZnNPs and senps co-adjuvants deliver superior and long-lasting protection: first report in inactivated Rift Valley fever vaccines for sheep.

Tropical medicine and infectious disease

Serologic Evidence of Circulation of Six Arboviruses (Dengue Virus, Chikungunya Virus, Zika Virus, Rift Valley Virus, Yellow Fever Virus, Crimean-Congo Hemorrhagic Fever Virus) in Four Regions of Burkina Faso, West Africa.

Proceedings of the National Academy of Sciences of the United States of America

Cryo-EM structure of the Rift Valley fever virus envelope protein in complex with a potent neutralization antibody.

Detection of Crimean-Congo hemorrhagic fever virus and Rift Valley fever virus antibodies in animal workers in Cameroon.

Viral zoonotic disease outbreaks and response strategies in Sub-Saharan Africa: a scoping review.

Journal of infection and public health

Seroprevalence of four zoonotic viral diseases in camels in Qatar.

Journal of medical virology

Molecular Characterization of Rift Valley Fever Virus From the 2025 Outbreak in Northern Senegal Reveals Lineage H Persistence and Key Polymerase Mutations.

Exploring community-based reporting of livestock abortions for rift valley fever and brucellosis surveillance in Uganda: a pilot study.

Seasonal variation in mosquito abundance and environmental predictors in semi-pastoral southern Kenya: implications for endemic Rift Valley fever.

Parasites & vectors

A Multi-Host Approach to Quantitatively Assess the Role of Dogs as Sentinels for Rift Valley Fever Virus (RVFV) Surveillance in Madagascar.

Incidence rate of Rift Valley fever exposure in humans and livestock from a longitudinal study in Northern Kenya.

Site-directed tyrosinase conjugation on engineered ferritin retains immune recognition.

JAK inhibitors remove innate immune barriers facilitating viral propagation.

NAR molecular medicine

Detection and genetic diversity of Wolbachia and its associated prophage WO in mosquito populations from Ethiopia.

The Lancet. Infectious diseases

Safety, tolerability, and immunogenicity of the ChAdOx1 RVF vaccine against Rift Valley fever among healthy adults in Uganda: a single-centre, single-blind, randomised, placebo-controlled, dose-escalation, phase 1 trial.

Infectious diseases (London, England)

Rift Valley fever in Mauritania and Senegal: A One Health imperative.

A system to rapidly develop a bunyavirus pseudotyped virus neutralisation assay for pandemic preparedness.

NPJ vaccines

Annals of medicine and surgery (2012)

MRNA innovation: preparing for arboviruses and the next global outbreak.

Targeting the Rift Valley Fever Virus Polymerase: Resistance Mechanisms and Structural Insights.

ACS infectious diseases

Immune Evasion by the NSs Protein of Rift Valley Fever Virus: A Viral Houdini Act.

Rift Valley Fever Virus Transmission During an Unreported Outbreak Among People and Livestock in South-Central Tanzania.

An integrative approach to DNA barcoding, geometric morphometrics, and machine learning for field identification of Culex mosquitoes (Diptera: Culicidae), with implications for vector-borne disease surveillance.

Acta tropica

A Single Dose of Live-Attenuated Rift Valley Fever Virus Vector Expressing Peste Des Petits Ruminants Virus (PPRV) H or F Antigens Induces Immunity in Sheep.

Vaccines

Tropical medicine and infectious disease

Impact of El Nino Southern Oscillation and Climate Change on Infectious Diseases with Ophthalmic Manifestations.

When nothing happens: could Theileria parva-like endemic stability explain Rift Valley fever's cryptic persistence during the inter-epidemic periods?

Revista Argentina de microbiologia

Rift Valley Fever Virus: An update on current status and future prospects.

Molecular biology reports

Harnessing eDNA metabarcoding for mosquito surveillance: a pilot study in Ethiopia's Great Rift Valley.

Epidemiology and infection

Rift Valley fever seroprevalence in ruminants in Dhobley town, Lower Juba region, Somalia, in 2021.

Non-malarial etiology of acute febrile episodes in children attending five healthcare facilities in Mwanza, Tanzania years 2020-2021.

Local drivers of Rift Valley fever outbreaks in Mauritania: A one health approach combining ecological, vector, host and livestock movement data.

Modeling sparse Rift Valley fever incidence data: a Bayesian perspective on zero-inflated self-exciting and autoregressive models.

bioRxiv : the preprint server for biology

Altered histone modifications in Aedes aegypti following Rift Valley fever virus exposure.

Rift Valley fever: A zoonotic disease with global potential.

Open veterinary journal

The American journal of tropical medicine and hygiene

Development of a Rapid Diagnostic Test to Distinguish between Emerging Viruses That Cause Hemorrhagic Fever.

Climate change and the emergence of Rift Valley fever virus: a pathological and environmental study of sheep jaundice in Egyptian slaughterhouses.

BMC veterinary research

An orally available 4'-fluorouridine prodrug inhibits SFTSV and LCMV infection.

International journal of molecular sciences

Ultrastructural Insight into Rift Valley Fever Virus Pathogenesis in Different Human Cell Types.

Effective treatment of advanced Oropouche virus, Rift Valley fever virus, and Dabie bandavirus infections with 4'-fluorouridine.

mBio

Frontiers in cellular and infection microbiology

A DNA vaccine candidate provides protection against Rift Valley Fever virus in sheep under natural field conditions.

Oropouche virus NSs protein suppresses host transcription by targeting the RNA polymerase II RPB1 protein.

The leader proteins of Theiler's virus and Boone cardiovirus use a combination of short linear motifs (SLiMs) to target RSK kinases to the nuclear pore complex.

Infectious diseases of poverty

Harnessing community-based one health interventions implementation beyond Mpox outbreak management in Africa: insights and benefits.

The Lancet. Planetary health

Rift Valley fever epidemiology: shifting the paradigm and rethinking research priorities.

Limiting viral replication in hematopoietic cells delays Rift Valley fever virus disease progression in C57BL/6 mice.

Seroprevalence of Rift Valley Fever Viruses Antibodies in Domestic Livestock in the Tahoua Region of Niger.

Veterinaria italiana

PLOS global public health

Rift Valley fever outbreak among animal handlers in Kinyogoga Village, Nakaseke District, Central Uganda: A case study.

Inter-epidemic seroprevalence of Rift Valley fever virus and associated risk factors in humans in Eastern Rwanda.

Molecular detection of Ehrlichia ruminantium in ticks from ruminants during the 2021 Rift Valley fever outbreak in Mananjary, Madagascar.

Parasitology research

Multiplex nucleic acid polymerase assay for eight severe hemorrhagic fever viruses based on dual-probe hybridization and melting curve analysis.

Infectious medicine

Journal of biological engineering

Baculovirus-mediated production and purification of ferritin nanoparticles for rift valley fever vaccine development.

Rift Valley fever virus and Coxiella burnetii infections among febrile patients, Eastern Ethiopia.

Hyperendemicity of Rift Valley Fever in Southwestern Uganda Associated With the Rapidly Evolving Lineage C Viruses.

Identification and Characterization of a Metal Binding-Independent Rift Valley Fever Virus Endonuclease Inhibitor.

ACS infectious diseases

Rift Valley fever seroprevalence and risk factors among human populations in Uganda's cattle corridor: a cross-sectional study.

BMJ public health

Highly sensitive and multiplex detection of nine potential bioterrorism viral agents in a single reaction by multiplex probe amplification (MPA) with melting curve analysis.

Microbiology spectrum

Rift Valley Fever Outbreak Investigation Associated with a Dairy Farm Abortion Storm, Mbarara District, Western Uganda, 2023.

Detection and Molecular Characterization of Rift Valley Fever Virus in Apparently Healthy Cattle in Uganda.

Effectiveness and equity of vaccination strategies against Rift Valley fever in a heterogeneous landscape.

Maternal vaccination with live-attenuated Rift Valley fever virus protects offspring via immune transfer.

NPJ vaccines

Emerging infectious diseases

Seroprevalence of Rift Valley and Crimean-Congo Hemorrhagic Fever Viruses, Benin, 2022-2023.

Research trends in Rift Valley fever virus: a bibliometric analysis from 1936 to 2024.

Proceedings. Biological sciences

Localized Rift Valley fever virus persistence explains epidemic and interepidemic dynamics and guides control strategies.

Current research in parasitology & vector-borne diseases

Factors contributing to mosquito-borne disease: A systematic review in the Middle East and North Africa (MENA) region.

Cultural and behavioral drivers of zoonotic disease transmission and persistence among diverse pastoralist communities in East Africa.

GMS hygiene and infection control

A comprehensive review on the epidemiology of arboviruses in the Eastern Mediterranean Region (EMRO): insights from the WHO's Regional Office.

Disease Risks for Restoring Endangered Sahelo-Saharan Antelope: A Literature Review.

EcoHealth

The public health threat of emerging phenuiviruses.

BMJ (Clinical research ed.)

How climate change is threatening Africa by supercharging Rift Valley fever.

Single-cycle Rift Valley fever virus particles from stable replicon cells enable discovery of antiviral CNX-1351 for multiple RNA viruses.

Virologica Sinica

High-throughput screening of E3 ubiquitin ligases identifies TRIM48 as a novel negative regulator of RIG-I signaling.

Cellular signalling

Rapid laboratory confirmation of the 2025 Sudan Virus Disease (Svd) index case in Uganda.

Humoral immunity is sufficient to protect mice against Rift Valley fever encephalitis following percutaneous exposure.

NPJ vaccines

Have you heard of Rift Valley fever? Findings from a multi-country study in East and Central Africa.

Ophthalmology and therapy

Climate Change and the Impact on Ocular Infectious Diseases: A Narrative Review.

Has the epidemiologic conundrum of Rift Valley fever changed?

Overexpression of cytochrome P450 and esterase genes in pyrethroid-resistant wild Culex quinquefasciatus populations from sub-Himalayan West Bengal, India.

Parasitology research

Developing digital learning to help reduce laboratory inequalities: a viral haemorrhagic fever case study.

Medical and veterinary entomology

Field studies of Culex mosquitoes in Tanzania and Kenya: A systematic review motivated by changing Rift Valley fever virus transmission patterns.

Development of a high-sensitivity vertical flow immunoassay for the detection of Rift Valley fever virus.

Microbiology spectrum

Portable microfluidic-LAMP assay for rapid on-site detection of eight highly pathogenic viruses.

Analytica chimica acta

Zoonotic arbovirus infections in cattle in Mozambique with special reference to Crimean-Congo hemorrhagic fever virus (CCHFV) and rift valley fever virus (RVFV).

Phylogenetic insights into the transmission dynamics of arthropod-borne viruses.

Nature reviews. Genetics

African journal of reproductive health

Rift valley fever in Sudan: Assessing public awareness and preventive practices in Al-Karad.

Successful Inactivation of High-Consequence Pathogens in PrimeStore Molecular Transport Media.

Life (Basel, Switzerland)

Viruses in Simuliidae: An Updated Systematic Review of Arboviral Diversity and Vector Potential.

Spatial and temporal analysis of Rift Valley fever outbreaks in livestock in Uganda: a retrospective study from 2013 to 2022.

BMC veterinary research

Journal of health, population, and nutrition

Economic burden of zoonotic and infectious diseases on livestock farmers: a narrative review.

Assessing human liver spheroids as a model for antiviral drug evaluation against BSL-3 haemorrhagic fever viruses.

Antiviral research

Gender and exposure pathways to zoonotic infections in communities at the interface of wildlife conservation areas of Uganda: A qualitative study.

Global public health

Recent advances in treatment and detection of Rift Valley fever virus: a comprehensive overview.

Virus genes

One Health Economics approach to prevention and control of zoonotic and animal diseases - considerations for South Africa.

Journal of virological methods

Technical validation of a multiplex real-time PCR for combined detection of Rift Valley fever, chikungunya, Zika and dengue viruses.

Genetic estimates and genome-wide association studies of antibody response in Tanzanian dairy cattle.

Frontiers in genetics

Developing Indirect rRVFV-NP based ELISA Protocol for Detection of IgG Against Rift Valley Fever Virus.

The new microbiologica

Frontiers in public health

Knowledge, attitudes, practices (KAP), and risk factors toward zoonotic diseases among smallholder livestock farmers in Bugesera district of Rwanda.

medRxiv : the preprint server for health sciences

Advance Warning and Response Systems in Kenya: A Scoping Review.

Tropical diseases, travel medicine and vaccines

Current epidemiological status of mosquito-borne arboviruses in Gulf countries: a systematic review and meta-analysis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Bridging knowledge gaps in phytotherapy for a neglected zoonotic disease: Rift valley fever.

Transboundary and emerging diseases

Evaluation of a Luminex-Based Multiplex Immunoassay of Hemorrhagic Fever Viruses in Senegal.

Screening of Neutralizing Antibodies Targeting Gc Protein of RVFV.

Gender roles in ruminant disease management in Uganda: Implications for the control of peste des petits ruminants and Rift Valley fever.

Tropical medicine and infectious disease

Baseline Seroprevalence of Arboviruses in Liberia Using a Multiplex IgG Immunoassay.

Stability analysis of Rift Valley fever transmission model with efficient and cost-effective interventions.

Mechanisms of action of repurposed Ebola virus antivirals - the roles of phospholipidosis and cholesterol homeostasis.

Antiviral research

In vitro larvicidal activity of selected azabenzimidazole and diarylquinoline derivatives against Anopheles gambiae and in silico mechanistic analysis.

Molecular diversity

One Health investigation and response to a nationwide outbreak of Rift Valley fever in Rwanda - March to December 2022.

Evaluating the potential of anti-dsRNA antibodies as an alternative viral sensing tool in encephalitides of different species.

Epidemiology of arboviruses in humans and livestock in Ethiopia: a systematic review and meta-analysis.

Development of FRET-based cap-snatching endonuclease assay.

Microbiology spectrum

A Novel BoHV-1-Vectored Subunit RVFV Vaccine Induces a Robust Humoral and Cell-Mediated Immune Response Against Rift Valley Fever in Sheep.

Uncovering the viral aetiology of undiagnosed acute febrile illness in Uganda using metagenomic sequencing.

Nature communications

Meeting report: CEPI workshop on Rift Valley fever epidemiology and modeling to inform human vaccine development, Nairobi, 4-5 June 2024.

Vaccine

Drug repositioning as a promising approach for the eradication of emerging and re-emerging viral agents.

Molecular diversity

Seroepidemiological Reconstruction of Long-term Rift Valley Fever Virus Circulation in Nouakchott, Mauritania.

The Temperature-Associated Effects of Rift Valley Fever Virus Infections in Mosquitoes and Climate-Driven Epidemics: A Review.

medRxiv : the preprint server for health sciences

PROJECTING CLIMATE CHANGE IMPACTS ON INTER-EPIDEMIC RISK OF RIFT VALLEY FEVER ACROSS EAST AFRICA.

Rift Valley fever virus coordinates the assembly of a programmable E3 ligase to promote viral replication.

Cell

Antibodies (Basel, Switzerland)

Efficient Identification of Monoclonal Antibodies Against Rift Valley Fever Virus Using High-Throughput Single Lymphocyte Transcriptomics of Immunized Mice.

Rift Valley Fever Virus Infectivity in Milk Stored at a Wide Range of Temperatures.

Advances in antiviral strategies targeting mosquito-borne viruses: cellular, viral, and immune-related approaches.

Mapping livestock systems, bovine and caprine diseases in Mayo-Kebbi Ouest Province, Chad.

Geospatial health

Appraisal of World Health Organization guidelines for priority infectious diseases with potential to cause public health emergencies.

Public health

Pasteurization temperatures effectively inactivate Rift Valley fever viruses in milk.

Exploiting venom toxins in paratransgenesis to prevent mosquito-borne disease.

Parasites & vectors

"Without a man's decision, nothing works": Building resilience to Rift Valley fever in pastoralist communities in Isiolo Kenya.

Journal of medical virology

A Novel HTNV Budding Inhibitor Interferes the Interaction Between Viral Glycoprotein and Host ESCRT Accessory Protein ALIX.

medRxiv : the preprint server for health sciences

Atypical hyperendemicity of Rift Valley fever in Southwestern Uganda associated with the rapidly evolving lineage C viruses.

The Dissemination of Rift Valley Fever Virus to the Eye and Sensory Neurons of Zebrafish Larvae Is Stat1-Dependent.

Co-Infection of Culex tarsalis Mosquitoes with Rift Valley Fever Phlebovirus Strains Results in Efficient Viral Reassortment.

Identification of Potential Vectors and Detection of Rift Valley Fever Virus in Mosquitoes Collected Before and During the 2022 Outbreak in Rwanda.

Rift Valley Fever in Rwanda Is Urging for Enhancing Global Health Security Through Multisectoral One Health Strategy.

Microorganisms

Veterinary parasitology, regional studies and reports

Characterization of Culicoides and mosquito fauna at the National Zoological Garden of Rabat, Morocco.

The Lancet. Planetary health

A framework for ecologically and socially informed risk reduction before and after outbreaks of wildlife-borne zoonoses.

Evidence of human exposure and associated risk factors to Rift Valley fever in selected districts of Central and Western Zambia.

Molecular therapy. Methods & clinical development

Research progress of mosquito-borne virus mRNA vaccines.

Enzootic Ovine Abortion among small ruminants in Southern Benin.

Veterinaria italiana

European journal of public health

Achievement of one health multi-sectoral collaboration in containment of Rift Valley Fever outbreak, Sudan, Red Sea State 2019.

European journal of public health

Evaluating the burden and transmission dynamics of chikungunya virus infections in the Eastern Mediterranean Region: a systematic review and meta-analysis.

Animals : an open access journal from MDPI

Diseases of Economic Importance in Feedlot Cattle in Sub-Saharan Africa: A Review with a Focus on Existing and Potential Options for Control.

Serological Evidence of Cryptic Rift Valley Fever Virus Transmission Among Humans and Livestock in Central Highlands of Kenya.

Heat Treatment as a Safe-Handling Procedure for Rift Valley Fever Virus.

Tropical medicine & international health : TM & IH

TaqMan Array Card real-time polymerase chain reaction panel to detect pathogens in whole blood of febrile inpatients in northern Tanzania, 2016-2019.

Seroprevalence of Brucella spp. and Rift Valley fever virus infections in communal pastoral cattle at the wildlife-livestock interface, Zambezi region, Namibia.

Development of a luminex-based assay for the detection of anti-capripoxvirus and rift valley fever virus antibodies in domestic ruminants.

Undetected circulation of major arboviruses in West Sudan: urging for institutionalizing multisectoral one health strategy for the preparedness, prevention, and control of zoonotic arboviral diseases.

BMC research notes

Frontiers in public health

Rift Valley Fever outbreaks in the East African Community: insights from ProMed data (2010-2024).

Efficient Expression of Oropouche Virus Nonstructural Proteins NSs and NSm.

Bunyaviruses: Expression of Recombinant Glycoproteins from Insect Cells.

Recombinant Protein Production and Purification of Rift Valley Fever Virus Nucleoprotein from Escherichia coli Expression Systems.

Vector Competence Assays for RVFV in Mosquitoes.

Cryogenic Electron Microscopy of Rift Valley Fever Virus.

Molecular Diagnosis of Phlebovirus riftense Infection Using an L-Segment-Based Real-Time RT-PCR Method.

Use of Rift Valley Fever Virus Expressing NanoLuc Luciferase for the Assessment of Neutralizing Antibodies and Antivirals.

Novel replication-competent reporter-expressing Rift Valley fever viruses for molecular studies.

Comparative study of two Rift Valley fever virus field strains originating from Mauritania.

Medical science monitor : international medical journal of experimental and clinical research

A Review of Emerging Viral Pathogens and Current Concerns for Vertical Transmission of Infection.

bioRxiv : the preprint server for biology

Lrp1 facilitates infection of neurons by Jamestown Canyon virus.

Epidemiologic and Genomic Characterization of an Outbreak of Rift Valley Fever Among Humans and Dairy Cattle in Northern Tanzania.

Goat seropositivity as an indicator of Rift Valley fever (RVF) infection in human populations: A case-control study of the 2018 Rift Valley fever outbreak in Wajir County, Kenya.

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