Síndrome Stevens-Johnson

Drug Reactions Sampling (COLLECTIONTOXIDERMIES)

NCT03659227

RECRUTANDO

Subconjunctival Humira for Boston Keratoprosthesis

NCT06926478

EM ANDAMENTO

Autologous Serum Obtained by a Closed-Circuit Collection Device

NCT07014059

EM ANDAMENTO

Outcomes in Stevens Johnsons Syndrome and Toxic Epidermal Necrolysis

NCT03585946

DESCONHECIDO

G-CSF in the Treatment of Toxic Epidermal Necrolysis

NCT02739295

CONCLUÍDO

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Outros ensaios clínicos

41 ensaios clínicos encontrados, 3 ativos.

Distribuição por fase

NCT06926478 · Subconjunctival Humira for Boston KeratoprosthesisEm breve

PHASE1

NCT07014059 · Autologous Serum Obtained by a Closed-Circuit Collection Dev…Em breve

PHASE2

NCT03585946 · Outcomes in Stevens Johnsons Syndrome and Toxic Epidermal Ne…Cancelado

NCT02739295 · G-CSF in the Treatment of Toxic Epidermal NecrolysisConcluído

PHASE4

NCT02987257 · NATIENS: Optimal Management and Mechanisms of SJS/TENConcluído

PHASE3

NCT04313725 · Evaluation of Tangible Boost for Patients With Stevens Johns…Encerrado

NCT06474078 · Study To Evaluate The Efficacy Of Tofacitinib In Patients Wi…Concluído

NCT02945176 · Safety and Performance Study of the ARGOS-IO System in Patie…Concluído

NCT06522048 · SJS/TEN or Other Cutaneous Adverse Eevents Induced by Immune…Concluído

NCT05520086 · Clinical Trial to Evaluate Safety and Efficacy of Cell Thera…UNKNOWN

PHASE1, PHASE2

NCT06263140 · Vitamin D Levels in Non-immediate Drug Hypersensitivity Case…Concluído

NCT05320653 · Nutritional and Metabolic Management of Toxidermia Patients …Concluído

NCT05284929 · Human Leukocyte Antigen Class II (DRB1 and DQB1) Alleles and…UNKNOWN

NCT05145959 · Meibomian Gland Probing in the Sub-Acute Phase of Patients W…UNKNOWN

NCT01582880 · Use of Cross-linked Donor Corneas as Carriers for the Boston…Concluído

PHASE1, PHASE2

NCT02574988 · Severe Cutaneous Adverse Reactions in ThailandUNKNOWN

NCT03839069 · Minor Salivary Gland Transplantation for Cicatrizing Conjunc…UNKNOWN

NCT02126020 · Topical Infliximab in Autoimmune Eyes With KeratoprosthesisCancelado

PHASE1, PHASE2

NCT03046914 · HLA-B*5801 Screening to Prevent Allopurinol-induced Severe C…UNKNOWN

Ver todos no ClinicalTrials.gov

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Publicações mais relevantes

Timeline de publicações

2.708 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 2.708

#1

Mechanisms and Targeted Therapeutic Strategies for Inflammation and Renal Fibrosis in Hyperuricemic Nephropathy.

Cell biochemistry and function2026 Feb

Hyperuricemia (HUA) is a growing global health issue driven by economic development and lifestyle changes. Approximately 75% of uric acid in humans is excreted renally. Excess uric acid deposits in renal tissues, promoting tubulointerstitial fibrosis and leading to hyperuricemic nephropathy (HN), which is characterized by urate crystal deposition, chronic interstitial nephritis, and renal fibrosis. The pathogenesis and progression of HN involves dysregulated activation of multiple signaling pathways, including MAPK, Nrf2/HO-1/NQO1, PI3K/AKT, and ASK1/JNK/c-Jun pathways, which facilitate disease progression through the production of pro-inflammatory cytokines and other mediators. Current treatments primarily consist of urate-lowering drugs such as allopurinol, febuxostat, benzbromarone, and probenecid, but their use is constrained by adverse effects including hepatotoxicity, nephrotoxicity, and Stevens-Johnson syndrome. Therefore, targeting inflammatory and fibrotic mechanisms presents a promising therapeutic approach. This review outlines key molecular pathways in HN, discusses contemporary research challenges, and suggests future directions for improved therapeutic strategies.

#2

Randomised Controlled Trial on Sodium Valproate and Levetiracetam in Children with New-Onset Epilepsy.

Indian journal of pediatrics2026 Jan 23

To compare the efficacy of sodium valproate (VPA) and levetiracetam (LEV) as initial maintenance monotherapy in children with new-onset epilepsy. This randomised controlled trial was conducted in tertiary pediatric epilepsy and neurology clinics. Children 2-18 y with new-onset epilepsy were enrolled as participants. Patients were prescribed VPA (n = 58) or LEV (n = 58) at 20 mg/kg/d in two doses with increments of 20 mg/kg/d to a maximum of 60 mg/kg/d (Maximum daily dose: VPA 2 g/d and LEV 3 g/d). Primary outcome was the proportion of patients who achieved seizure control for three consecutive months. Secondary outcomes included the proportion of patients who achieved a 50% reduction in seizures from baseline and those who developed side-effects. A total of 116 patients were analysed using intention-to-treat analysis. There was no difference in the primary outcome between LEV vs. VPA groups [58.6% vs. 65.5%; relative risk (RR) 0.89 (95% CI, 0.67-1.19), p = 0.444]. There was no difference in patients who achieved a 50% seizure reduction from baseline between the two groups (70.7% vs. 70.7%) and side-effect profile (32.8% vs. 46.6%, p = 0.128) other than median (IQR) weight gain (kg), which was significantly lower in the LEV group (1.35, 0.70-1.60) as compared to the VPA group (2.15, 1.40-2.60) (p < 0.001). One patient in the VPA group had Stevens-Johnson syndrome. No mortality occurred. No difference was noted between sodium valproate and levetiracetam in seizure control. With a favorable side-effect profile, levetiracetam can be safely considered as initial maintenance monotherapy in children with new-onset epilepsy.

#3

A case of Stevens-Johnson syndrome triggered by Mycoplasma infection.

Journal of oral science2026

Stevens-Johnson syndrome (SJS) is a rare, potentially life-threatening mucocutaneous disorder, which is often triggered by infections such as Mycoplasma pneumoniae. This report describes a 19-year-old woman who initially presented with oral erosions and painful blisters, along with fever and cough. Oral lesions preceded skin and ocular involvement, and tests confirmed Mycoplasma-associated SJS. She responded to steroid pulse therapy but relapsed at 3 months and was then successfully treated. Oral manifestations may be early SJS indicators; thus, prompt recognition and interdisciplinary care by oral health professionals are vital for improving clinical outcomes.

#4

Validation of International Classification of Diseases Codes for Dermatologic Conditions: A Systematic Review.

JAMA dermatology2026 Feb 01

Accurate classification of dermatologic conditions using International Classification of Diseases (ICD) codes is essential for research that uses large administrative datasets. Misclassification can be associated with biased epidemiologic estimates and misleading conclusions in population-based studies. To systematically identify and evaluate validated classification approaches for dermatologic conditions using ICD codes in US-based administrative, claims, or electronic health record data. A systematic review was conducted that was registered with PROSPERO (CRD420250654233) and reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive search of Ovid MEDLINE, Embase, Web of Science, and CINAHL was conducted for studies published from January 1, 2000, to October 21, 2025. The data were analyzed in October 2025. Eligible studies evaluated International Classification of Diseases, Ninth Revision (ICD-9) or International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) codes used to identify dermatologic conditions in US-based datasets and reported at least 1 classification metric (eg, positive predictive value). To minimize selection and extraction bias, all screening and data extraction were performed independently by 2 reviewers, with discrepancies resolved by consensus. A total of 59 studies met inclusion criteria. Most reported positive predictive value, with few reporting sensitivity or specificity. Classification accuracy varied widely by condition and coding strategy. Studies included inflammatory and autoimmune conditions (eg, acne vulgaris, perioral dermatitis, psoriasis, palmoplantar pustulosis, hidradenitis suppurativa, atopic dermatitis, prurigo nodularis, dermatomyositis, cutaneous lupus erythematosus, pyoderma gangrenosum, cutaneous sarcoidosis, pemphigus, pemphigoid, granuloma annulare, alopecia areata, and vitiligo), actinic keratosis and skin cancer, pigmentary and hair disorders (eg, androgenic alopecia, cicatricial alopecia, lichen planopilaris, and melasma), drug reactions (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis), and infections (eg, herpes zoster, herpes simplex virus, and cellulitis or abscess). Classification algorithms that incorporated 2 or more codes, dermatologist attribution, or treatment/procedural data often achieved the highest accuracy. Conditions lacking validated algorithms included seborrheic dermatitis, rosacea, fungal infections, and specific alopecia subtypes. This systematic review provides a summary of the most accurate classification approaches to identify various dermatologic conditions in large administrative datasets. These results may inform study designs when using these datasets. In addition, some common conditions lack validated classification approaches, highlighting important areas for future research. As administrative and electronic health record data increasingly support dermatology research, use of rigorously validated algorithms will be essential for generating trustworthy findings.

#5

Safety profile of enfortumab vedotin plus pembrolizumab in locally advanced or metastatic urothelial carcinoma: a multicenter Japanese cohort study.

Japanese journal of clinical oncology2026 Feb 13

Enfortumab vedotin plus pembrolizumab (EVP) has shown promising efficacy in locally advanced or metastatic urothelial carcinoma (la/mUC), but real-world data in Japanese patients are limited. We assessed the safety and early efficacy of EVP, with a focus on cutaneous adverse events (AEs). We retrospectively analyzed 48 Japanese patients with la/mUC treated with first-line EVP at 12 centers between November 2024 and March 2025. Clinical data, AEs, and tumor responses were collected. Cutaneous AEs were evaluated for onset, severity, and management. Tumor response was assessed using Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1. The patients' median age was 76 years, and 89.6% were cisplatin-ineligible. All patients experienced treatment-related AEs, with 39.6% having grade ≥3 events. Cutaneous AEs occurred in 60.4%, including 18.8% with grade ≥3 rash and two cases of Stevens-Johnson syndrome. The median time to discontinuation due to AEs was 14 days. The overall response rate was 39.6%, and the disease control rate was 69%, rising to 87% among 38 evaluable patients. EVP demonstrated favorable early efficacy in Japanese patients but was associated with frequent early discontinuation due to AEs, particularly cutaneous toxicity. Early skin care and interdisciplinary management are essential. These findings support EVP use while emphasizing AE management and patient-centered care.

Publicações recentes

Suspected Stevens-Johnson Syndrome After Azithromycin and Doxycycline Exposure in an Elderly Woman: A Case Report Showcasing Treatment Based on Clinical Diagnosis.

Cureus2026 Mar

Stevens-Johnson Syndrome following a Single Ampicillin Dose in an Elderly Patient: A Case Report.

Case Rep Dermatol2026 Jan-Dec

[DIAGNOSIS AND MANAGEMENT OF SEVERE CUTANEOUS ADVERSE DRUG REACTIONS].

Arerugi2026

Plasma Cytokine and Chemokine Profile in Hospitalized Toxic Epidermal Necrolysis Patients.

Clin Exp Dermatol2026 Apr 9

When Infection and Drug Hypersensitivity Converge: An SJS-Like Mucocutaneous Reaction.

Int J Dermatol2026 Apr 12

Ver todas no PubMed

📚 EuropePMC2.889 artigos no totalmostrando 197

BMC cardiovascular disorders

Cutaneous adverse drug reactions in patients with congenital heart disease: a systematic review with focus on perioperative outcomes.

The Hidden Perils of Allopurinol: A Systematic Review of Allopurinol-Induced DRESS (Drug Reaction With Eosinophilia and Systemic Symptoms) Syndrome.

The Journal of sports medicine and physical fitness

The effects of anabolic-androgenic steroids administration on oral health in humans: a scoping review.

A Rash Decision: Mycoplasma-Induced Mucositis in a Young Adult.

Sintilimab-induced toxic epidermal necrolysis complicated in advanced gastric cancer: a case report and literature review.

Clinical toxicology (Philadelphia, Pa.)

Lamotrigine-induced Stevens-Johnson syndrome: a systematic review of case reports and case series.

International journal of dermatology

Beyond the Target: Re-Emergence of Mycoplasma pneumoniae Supports Reclassification of Adult Mucocutaneous Eruptions.

SEVERE TOXIC EPIDERMAL NECROLYSIS COMPLICATED BY ACUTE KIDNEY INJURY: DIAGNOSTIC AND THERAPEUTIC CONSIDERATIONS.

Georgian medical news

Toxic epidermal necrolysis in a preschooler associated with adenovirus respiratory infection: A case report.

SCORTEN and Novel Prognostic Markers in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Systematic Review and Meta-Analysis.

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review of Cases Secondary to Topical Medications.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

Cutaneous and non-cutaneous diseases due to Mycoplasma pneumoniae in children.

Journal of burn care & research : official publication of the American Burn Association

Predictors of Survival and Length of Stay in Steven Johnson syndrome and toxic epidermal necrolysis: A single centre retrospective study of 111 patients.

JNMA; journal of the Nepal Medical Association

Clinical Profile and Visual Rehabilitation with Mini-Scleral Device in Irregular Corneas at a Tertiary Eye Hospital : An Observational Study.

Prediction of antibiotic-associated cutaneous adverse drug reactions using electronic health record foundation models.

NPJ digital medicine

International archives of allergy and immunology

A narrative review of drug-induced haemophagocytic lymphohistiocytosis: A rare but relevant differential diagnosis.

The Journal of dermatological treatment

Soluble Fas Ligand, an overlooked target of therapy in dermatological and non-dermatological conditions.

The World Allergy Organization journal

Evaluation of drug causality in SJS/TEN: The role of the lymphocyte transformation test and conventional/modified IFN-γ ELISpot assays.

Indian journal of pharmacology

A rare drug reaction: Toxic epidermal necrolysis following polymyxin B administration in a post-Bentall procedure.

From Respiratory Pathogen to Systemic Threat: Rethinking Mycoplasma pneumoniae Infections.

Microorganisms

Reactive Infectious Mucocutaneous Eruption (RIME) Associated with Mycoplasma pneumoniae: Clinical and Immunological Insights from Pediatric Cases.

Microorganisms

The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians

Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis Possibly Related to Daptomycin And Ceftaroline in a Patient With Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia: A Case Report and Brief Review.

Clinical and experimental dermatology

The effect of different therapies and complete blood cell count-derived inflammatory biomarkers on the prognosis of Stevens-Johnson syndrome and toxic epidermal necrolysis.

Amitriptyline Induced Life-Threatening Steven-Johnson Syndrome: Case Report.

Clinical case reports

A 10-Year Retrospective Cohort Study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis at the Royal Brisbane and Women's Hospital.

Nevirapine-induced Stevens-Johnson Syndrome in an HIV-exposed neonate: A case report.

IDCases

Stevens-Johnson syndrome/toxic epidermal necrolysis induced by sintilimab in a patient with advanced non-small cell lung cancer: A case report.

Indian dermatology online journal

Insights into Severe Cutaneous Adverse Drug Reactions: A 5-Year Retrospective Analysis of Stevens- Johnson Syndrome- Toxic Epidermal Necrolysis and Drug Rash with Eosinophilia and Systemic Symptoms.

Dermatology online journal

Stevens-Johnson syndrome as the presenting manifestation of human immunodeficiency virus and syphilis coinfection.

International medical case reports journal

Adverse Drug Reaction to Paracetamol: Case Report of Oral Manifestation of Stevens-Johnson Syndrome in Children.

Journal of biochemical and molecular toxicology

Molecular Insights Into TNF-α and IFN-γ-Induced Epithelial Cell Death in Toxic Epidermal Necrolysis.

Cell biochemistry and function

Mechanisms and Targeted Therapeutic Strategies for Inflammation and Renal Fibrosis in Hyperuricemic Nephropathy.

The International journal of risk & safety in medicine

A case of delayed-onset Stevens-Johnson syndrome following co-amoxiclav administration in a 98-year-old female.

Diagnosis and Management of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Pediatric Patients: A Systematic Review of Clinical Guidelines and Consensus Statements.

Pediatric dermatology

Radiologie (Heidelberg, Germany)

[Drug-induced hypersensitivity reactions : Pulmonary manifestations and radiological characteristics].

Toxic Epidermal Necrolysis in Pregnancy: A Case Report.

A case of toxic epidermal necrolysis associated with vonoprazan, a potassium-competitive acid blocker.

Nimesulide-Associated Generalized Bullous Fixed Drug Eruption: A Rare Pharmacovigilance Case Report.

Factors associated with penicillin and sulfonamide allergy and Stevens-Johnson syndrome/toxic epidermal necrolysis.

AIDS (London, England)

Racial Disparities in Severe Cutaneous Adverse Reactions: A Report of Two Cases on Preventable Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Prescription Errors Through Medication Stewardship.

Journal of surgical case reports

Treatment of toxic epidermal necrosis lesions with ovine forestomach matrix.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

Toxic epidermal necrolysis associated with immune checkpoint inhibitors for bladder cancer: A case report.

Efficacy of Cultivated Oral Mucosal Epithelial Transplantation for Limbal Stem Cell Deficiency in Stevens-Johnson Syndrome Versus Other Etiologies.

Cornea

British journal of clinical pharmacology

Cyclosporine use in paediatric dermatologic conditions: A comprehensive review of therapeutic applications.

The British journal of dermatology

Development of a health-related quality of life outcome measure for adults with Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) - QoLTEN: An international multidisciplinary DELPHI consensus survey.

Effective management of pembrolizumab-induced Stevens-Johnson syndrome/toxic epidermal necrolysis overlap with upadacitinib.

Cutaneous Toxicities of Small Molecules in Targeted Cancer Therapy Part I - Mechanisms of Toxicity.

Cutaneous Toxicities of Small Molecules in Targeted Cancer Therapy Part II - Approach to Management and Treatment.

Journal of burn care & research : official publication of the American Burn Association

The Outcomes of SJS/TEN: A Nationwide Analysis.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Diagnosis and treatment of cutaneous adverse effects of targeted therapy, antibody-drug conjugates, and immunotherapy in cancer patients: a national consensus statement by the Spanish Society of Medical Oncology and the Spanish Academy of Dermatology and Venereology.

Predictive value of a severity-of-illness score for toxic epidermal necrolysis (SCORTEN) factors for in-hospital mortality in Stevens-Johnson syndrome/toxic epidermal necrolysis.

Frontiers in medicine

Immune checkpoint inhibitor-related Stevens-Johnson syndrome and toxic epidermal necrolysis: a retrospective analysis of 21 cases.

Pharmaceuticals (Basel, Switzerland)

Real-World Data on Severe Cutaneous Adverse Reactions to Drugs.

International journal of clinical pharmacology and therapeutics

Epidemiological characteristics of severe skin adverse reactions caused by immune checkpoint inhibitors based on case reports.

Indian journal of pediatrics

Randomised Controlled Trial on Sodium Valproate and Levetiracetam in Children with New-Onset Epilepsy.

Northern clinics of Istanbul

Severe cutaneous adverse drug reactions due to antituberculosis drugs and their management.

Real-world efficacy and safety of disitamab vedotin monotherapy or in combination with PD-1 inhibitors in locally advanced or metastatic upper tract urothelial carcinoma: a multicenter retrospective study.

The journal of allergy and clinical immunology. In practice

Evidence of a Therapeutic Window for TNF-α Inhibitor and Intravenous Immunoglobulin Benefits in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Treatment: A Multicenter 6-Year Retrospective Study.

Seminars in ophthalmology

The Role of the Boston Keratoprosthesis in Severe Ocular Surface Disease and Autoimmune Diseases.

Frontiers in pharmacology

Spectrum mining of immune checkpoint inhibitor-related cutaneous toxicities and analysis of associated factors based on FAERS.

SAGE open medical case reports

Stevens-Johnson syndrome/toxic epidermal necrolysis as the initial presentation of paraneoplastic anti-TIF1-γ dermatomyositis.

Case reports in dermatological medicine

Drug-Induced Fuchs Syndrome With Isolated Oral Involvement: A Rare Case Report.

A case of Stevens-Johnson syndrome triggered by Mycoplasma infection.

Journal of oral science

Gan to kagaku ryoho. Cancer & chemotherapy

[A Case of Toxic Epidermal Necrolysis during Chemotherapy for Advanced Gastric Cancer].

International journal of dermatology

Clinicopathologic and Immunohistochemical Features of Enfortumab Vedotin-Induced Cutaneous Toxicity.

The journal of allergy and clinical immunology. In practice

Generalized Bullous Fixed Drug Eruption: A Systematic Review.

Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne

Microbiological findings and antimicrobial resistance dynamics in pathogens isolated from patients with toxic epidermal necrolysis: a single center experience.

Journal of dermatological science

Comparative analysis of cytotoxic mediators in Stevens-Johnson syndrome and toxic epidermal necrolysis using ex vivo human epidermis.

Taiwan journal of ophthalmology

Restoring the mucin barrier: Advances in secretagogue therapies for ocular surface disorders.

Outcome of sutureless amniotic membrane dressing ring for acute Stevens-Johnson syndrome with severe ocular involvement: A case report of 5 patients.

Guidelines for the Management of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis 2025 Supplement.

Osteo-odonto-keratoprosthesis: a surgical procedure for treating advanced corneal diseases.

The Saudi dental journal

Validation of International Classification of Diseases Codes for Dermatologic Conditions: A Systematic Review.

JAMA dermatology

Just the facts: diagnosis and management of Stevens-Johnson syndrome/toxic epidermal necrolysis.

CJEM

Recent advances in inflammation & allergy drug discovery

IL-6 as a Potential Sensitive Serum Biomarker in Stevens-johnson Syndrome/Toxic Epidermal Necrolysis: Two Case Reports.

The journal of allergy and clinical immunology. In practice

Blistering Drug Eruptions: Diagnostic Challenges and Management in Clinical Practice: Unmasking the Cause: A Grand Rounds Review of Blistering Drug Eruption.

Longitudinal Immune Profiling of T Cell Exhaustion During IL-17A Blockade in a Patient With HLA-B27-negative Spondyloarthritis and Sjögren's Syndrome: A Case Report.

In vivo (Athens, Greece)

The Gut Microbiome in Stevens-Johnson Syndrome and Sjögren's Disease: Correlations with Dry Eye.

Microorganisms

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Risk factors and predictive score for phenytoin-induced cutaneous reactions.

Case Report: Successful weaning after 113 days of VV-ECMO in a pediatric patient with severe ARDS following Stevens-Johnson syndrome.

Frontiers in pediatrics

Journal of the European Academy of Dermatology and Venereology : JEADV

A scoping review of case reports and small case series in Stevens-Johnson syndrome/toxic epidermal necrolysis.

Actas dermo-sifiliograficas

Severe Cutaneous Signs of Hipersensitivity to Drugs in a Pediatric Hospital.

Reactive Infectious Mucocutaneous Eruption Following Isolated Rhinovirus Infection: Clinical Presentation and Treatment Response.

The Predictive Value of Inflammatory Markers in the Severity and Mortality Risk of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.

Increased TNF-α in SJS/TEN induced by PD-1 inhibitors supports the combination therapy of etanercept and systemic corticosteroids.

Molecular immunology

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

Delayed presentation of pembrolizumab-induced SJS-TEN overlap syndrome.

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

Mycoplasma pneumoniae-induced rash and mucositis.

Italian journal of dermatology and venereology

Cheilitis: a comprehensive review and a new clinical classification proposal. Part 1: Isolated cheilitis.

[Clinical Approach to the Patient With Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Part II].

Revista medica de Chile

Evidence for the Use of Janus Kinase (JAK) Inhibitors in the Management of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Scoping Review.

Frontiers in pharmacology

Severe cutaneous adverse reactions to anti-osteoporosis drugs: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System database and a review of published cases.

The Korean journal of helicobacter and upper gastrointestinal research

Toxic Epidermal Necrolysis Induced by First-Line Helicobacter pylori Eradication Therapy: A Case Report.

Paediatric Stevens-Johnson syndrome and toxic epidermal necrolysis: patterns and outcomes in a retrospective Pakistani cohort.

BMJ paediatrics open

Chronic Ocular Complications in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: Clinical Features and Surgical Management in a Brazilian Tertiary Center.

Cornea

Long-Term Outcomes of Boston Type I Keratoprosthesis After Minor Salivary Gland Transplantation and Labial Mucous Membrane Grafting as an Alternative Treatment for Stevens-Johnson Syndrome.

Cornea

An Atypical Trigger of Stevens-Johnson Syndrome with Severe Ocular Complications.

Irish medical journal

Ocular administration of brinzolamide leading to Stevens-Johnson syndrome/toxic epidermal necrolysis overlap: A case report and review.

Actas dermo-sifiliograficas

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Induced by Topical Carbonic Anhydrase Inhibitors: A Literature Review.

Diagnostic sensitivity and specificity of mucosal involvement versus skin biopsy for Stevens-Johnson syndrome/toxic epidermal necrolysis.

Clinical and translational science

Cutaneous Adverse Effects of EGFR Therapy in Breast Cancer Treatment.

A Case of Generalized Fixed Drug Eruption Showing the Conjunctival Involvement With CD4+ Tissue-Resident Memory T Cell Accumulation.

Stevens-Johnson syndrome/toxic epidermal necrolysis induced by tislelizumab: a case report and literature review.

Evaluation of umbilical cord blood serum eye drops for severe dry eye in two distinct populations-Sjögren's syndrome and mustard gas-induced ocular injury: Protocol for a pilot randomized clinical trial.

PloS one

International journal of clinical pharmacy

Severe cutaneous adverse reactions linked to medications in children and adolescents: a pharmacovigilance study based on the FDA Adverse Event Reporting System database.

International journal of surgery case reports

Severe cutaneous adverse reaction to amoxicillin-clavulanate: Pediatric toxic epidermal necrolysis in the Gulf: A case report and literature review.

The Medical journal of Malaysia

Incidence and clinical patterns, severity and preventability of cutaneous adverse drug reactions among hospitalized patients in a tertiary centre.

Italian journal of dermatology and venereology

Cheilitis: a comprehensive review and a new clinical classification proposal. Part 2: Cheilitis associated with dermatological diseases, systemic diseases, or drug reactions.

Case reports in pediatrics

Reactive Infectious Mucocutaneous Eruption (RIME) Associated With Rhinovirus and HHV-7 in a 14-Year-Old Boy.

Levofloxacin-Induced Fuchs Syndrome: A Rare Atypical Stevens-Johnson Syndrome Variant With a Comprehensive Literature Review.

Case reports in medicine

Bioinformatics analysis of Rickettsia typhi autoimmune associations and screening of Streptomyces-derived inhibitors.

BioData mining

Case Report: Zonisamide-induced DRESS syndrome with progression toward SJS: the first Chinese case and review of the literature on ZNS-associated SCARs.

Frontiers in medicine

Pediatrics international : official journal of the Japan Pediatric Society

Examination of histopathological findings in Mycoplasma pneumoniae-induced rash and mucositis case.

Comparative Impact of NSAIDs Versus Acetaminophen on Mortality in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Retrospective Cohort Study of 2484 Patients From a Nationwide Inpatient Database.

Journal of clinical medicine

Complement Inhibitors in Generalized Myasthenia Gravis: Comparison of Administration Schedules, Efficacy, and Safety.

Journal of cutaneous pathology

Mycoplasma pneumoniae-Induced Rash and Mucositis: Clinicopathologic Characterization of 11 Cases.

Umbilical cord-derived mesenchymal stem cell therapy for acute Stevens-Johnson syndrome/Toxic Epidermal Necrolysis with severe ocular involvement.

Indian journal of ophthalmology

Ocular involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis: A review of current management and changing trends.

Presse medicale (Paris, France : 1983)

Update on dermatological toxicities of immune checkpoint inhibitors.

Archives of pathology & laboratory medicine

Immune Checkpoint Inhibitor-Related Epidermal Necrosis: Terminology, Pathology, and Clinical Implications.

PCN reports : psychiatry and clinical neurosciences

Cost-effectiveness analysis of pharmacogenetic-guided antiseizure medication therapy based on the risk of HLA-A*31:01 allele variants in Japan.

Surgical management of chronic Stevens-Johnson syndrome.

Frontiers in medicine

Characterization of the spectrum of cutaneous adverse reactions to enfortumab vedotin: A retrospective cohort study.

Journal of psychiatric research

Prevalence of dermatologic side effects of mood stabilizers in bipolar disorder: A systematic review and meta-analysis.

Cutaneous and ocular toxicology

Analysis of clinical characteristics of tislelizumab-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in the Chinese population: a systematic review.

Basic & clinical pharmacology & toxicology

Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Associated With Mebendazole Use.

Tislelizumab-associated toxic epidermal necrolysis in an esophageal cancer patient: a case report.

Japanese journal of clinical oncology

Safety profile of enfortumab vedotin plus pembrolizumab in locally advanced or metastatic urothelial carcinoma: a multicenter Japanese cohort study.

Pharmacoepidemiology and drug safety

Titel: Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Among Patients Treated With Immune Checkpoint Inhibitors Compared to Other Antineoplastic Medications: A Nationwide Study.

[Severe lichenoid drug eruption with oral involvement resembling Stevens-Johnson syndrome induced by carbamazepine: A case report].

Semergen

Apalutamide-induced life-threatening dermatologic toxicity: Clinical histopathological correlations and salvage therapies in four cases: Case report series.

International journal of molecular sciences

Allogeneic Umbilical Cord Blood Serum Eyedrops for the Treatment of Severe Dry Eye Disease Patients.

Recovering From Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

JAMA dermatology

Etoricoxib and its hidden risks: a case-based review of dermatological, hematological, and cardiovascular complications.

EXCLI journal

Allergology international : official journal of the Japanese Society of Allergology

Cytokine profile-guided management of Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN): A management algorithm useful for guiding the selection of treatment options.

A Case of Immunotherapy-Induced Balanitis.

Hypoalbuminemia and Nutritional Status in Docetaxel-Induced Erythema Multiforme: A Case Report.

Annales de dermatologie et de venereologie

Skin-adverse drug reactions in the elderly: An underestimated and avoidable issue.

International journal of dermatology

Stevens-Johnson Syndrome Induced by Radiotherapy Alone: A Rare and Well-Documented Case Without Concomitant Drug Exposure.

Paediatrics and international child health

Severe pneumonia with Mycoplasma pneumoniae-induced raѕh and mucositis in an 8-year-old boy.

Romanian journal of ophthalmology

Surgery for Symblepharon Developed Due to Stevens-Johnson Syndrome: Modified Ring Procedure Performed Through Amniotic Membrane Transplantation and a 6 French Aspiration Catheter.

Stevens-Johnson syndrome or toxic epidermal necrolysis from antihypertensive medications: A systematic review of cases.

Post-market surveillance data demonstrate high mortality associated with enfortumab vedotin skin toxicity, not worsened by immune checkpoint inhibitors or corticosteroids.

Recurrent Reactive Infectious Mucocutaneous Eruption (RIME) in a Pediatric Patient Triggered by Mycoplasma pneumoniae and Enterovirus Coinfection.

An Atypical Case of Toxic Epidermal Necrolysis Associated With Ceftriaxone.

Annals of medicine and surgery (2012)

Stevens-Johnson syndrome associated with daclatasvir and sofosbuvir co-therapy in hepatitis C treatment: a rare case report.

Pediatric vs adult Stevens Johnson syndrome/toxic epidermal necrolysis: Ocular outcomes and the role of amniotic membrane.

Psychological Complications of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review and Meta-Analysis.

Journal of pharmaceutical health care and sciences

Ofloxacin, paracetamol and cefixime induced Stevens-Johnson syndrome - toxic epidermal necrolysis in an adult female patient: a case report.

JAAD Game Changer: Retrospective cohort study characterizing PD-1/PD-L1 checkpoint inhibition associated Stevens-Johnson syndrome and toxic epidermal necrolysis.

Immune Checkpoint Inhibitors as Independent and Synergistic Drivers of SJS/TEN.

JAMA oncology

Ocular manifestations in Stevens‒Johnson syndrome/toxic epidermal necrolysis in cancer patients.

HLA-B*58:01 and Risk of Allopurinol-Induced Severe Cutaneous Adverse Reactions in the US.

JAMA dermatology

Advances in skin & wound care

Summary of the Best Evidence on Skin-Mucosal Care in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.

Infectious disease reports

More than Mucositis: Pediatric RIME Following Co-Infection with SARS-CoV-2 and Mycoplasma pneumoniae-A Case Report and Mini-Review.

Toxic Epidermal Necrolysis and Mortality: A Danish Cohort Study With 30 Years of Follow-Up.

Mycoplasma pneumoniae-Associated Mucositis: A Diagnostic Dilemma.

Clinical case reports

Postoperative Staphylococcal Toxic Shock Syndrome in a Patient Following Right Knee Fracture Repair: A Case Report.

The Kaohsiung journal of medical sciences

Fatal Pembrolizumab-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis in a Patient With Advanced Lung Adenocarcinoma.

Dermatologie (Heidelberg, Germany)

[Current dermatology guidelines in Germany: a selection of clinically relevant recommendations].

Biologic therapies for dermatologic emergencies: A comprehensive review.

Long-term cardiovascular morbidity in Stevens-Johnson syndrome: A retrospective TriNetX matched-cohort analysis.

Pediatric Mycoplasma pneumoniae-induced rash and mucositis in China: clinical spectrum, co-infections and risk factors for recurrence-a retrospective cohort study.

Frontiers in allergy

Seminars in ophthalmology

Unravelling Stevens-Johnson Syndrome: Clinicopathological Insights and Therapeutic Advances.

Amniotic membrane transplantation techniques in acute ocular Stevens-Johnson syndrome and toxic epidermal necrolysis: A systematic review.

Ocular immunology and inflammation

Relationship Between Chronic Ocular Surface and Meibomian Gland Changes and Clinical Assessment Tool in Cicatricial Conjunctival Diseases.

Toxic Epidermal Necrolysis and Recurrent Implantation Failure: Unveiling a Rare Phenomenon During Pregnancy.

Clinical case reports

Epidermal necrolysis (Stevens-Johnson syndrome/ toxic epidermal necrolysis) as extensive boundary violation: A qualitative study on the illness experience and care needs of survivors in the context of the first German guideline.

PloS one

[A CASE OF PEDIATRITIC TOXIC EPIDERMAL NECROSIS TRIGGERD BY OVER-THE-COUNTER EYE DROPS].

Arerugi = [Allergy]

Stevens-Johnson syndrome-toxic epidermal necrolysis spectrum reactions to immune checkpoint inhibitor therapy and safety of rechallenge: A retrospective review.

European annals of otorhinolaryngology, head and neck diseases

Extensive upper aerodigestive tract involvement in metamizole-induced Stevens-Johnson syndrome/toxic epidermal necrolysis.

Pediatric Stevens-Johnson syndrome and toxic epidermal necrolysis: age-stratified insights from the FAERS database.

Jornal de pediatria

Japanese journal of ophthalmology

Clinical course and efficacy of treatment with limbal-rigid contact lens wear for ocular sequelae in Stevens-Johnson syndrome/toxic epidermal necrolysis.

Biomedica : revista del Instituto Nacional de Salud

Multidisciplinary management of antiepileptic drug-induced toxic epidermal necrolysis in a young woman.

Virchows Archiv : an international journal of pathology

Myeloperoxidase-positive mononuclear cells predominate over CD3-positive T-lymphocytes in the epidermis of Stevens-Johnson syndrome and toxic epidermal necrolysis.

Clinical Outcomes of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Based on Hospital Admission Type.

Cutis

Frontiers in pharmacology

Advancing drug safety in psychiatry: insights from pharmacogenomics of hypersensitivity reactions.

Reactive Infectious Mucocutaneous Eruption: A Rising Enigma.

Acta medica portuguesa

Structured skin care for a patient with toxic epidermal necrolysis caused by anlotinib: Case report.

Inhibition of formyl peptide receptor-1-mediated cell death as a therapy for lethal cutaneous drug reactions in preclinical models.

Nature communications

Annals of agricultural and environmental medicine : AAEM

Difficulties in management of ocular surface in the late phase of toxic epidermal necrolysis - a rare case report.

Clinical, pathological and immunological features of toxic-epidermal necrolysis like lupus erythematosus: A systematic review and proposal for diagnostic criteria.

Lupus

Acta dermatovenerologica Alpina, Pannonica, et Adriatica

Toxic epidermal necrolysis: lessons from three fatal cases.

The British journal of dermatology

Long-term morbidity and quality of life in survivors of Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum.

Stevens-Johnson syndrome/toxic epidermal necrolysis-like acute cutaneous lupus erythematosus.

Medicina clinica

Indian journal of ophthalmology

Clinical outcomes of simple limbal epithelial transplantation for limbal stem cell deficiency in a Mexican population.

Immune checkpoint inhibitor-induced toxic epidermal necrolysis responding to repeated dosing of adjuvant therapy with etanercept.

European journal of human genetics : EJHG

Pharmacogenomics in drug therapy: global regulatory guidelines for managing high-risk drug reactions.

Vision (Basel, Switzerland)

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review of Ophthalmic Management and Treatment.

Vulvovaginal involvement in Stevens-Johnson syndrome/toxic epidermal necrolysis: A retrospective review at a tertiary care center (2016-2024).

Journal of inflammation research

Viral Triggers Exposed: A Systematic Review of Virus-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.

Photodermatology, photoimmunology & photomedicine

Photodistributed Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

Cyclosporine: An Emerging Therapeutic Agent for<br /> Paediatric Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

Oral Manifestations of Pediatric Multisystem Inflammatory Syndrome.

Emerging causes of anticancer therapies-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: evidence from disproportionality analysis of the FDA adverse event reporting system.

Internal medicine (Tokyo, Japan)

A Case of Acetaminophen-induced Toxic Epidermal Necrolysis with Airway Mucosal Lesions.

[Autologous oral mucosal epithelial transplantation in the treatment of bilateral limbal stem cell deficiency].

Vestnik oftalmologii

Azithromycin-Induced Stevens-Johnson Syndrome in a Patient With SARS-CoV-2 and End-Stage Renal Disease.