Tumor maligno, geralmente agressivo, composto por melanócitos neoplásicos atípicos. Na maioria das vezes, os melanomas surgem na pele (melanomas cutâneos) e incluem os seguintes subtipos histológicos: melanoma extensivo superficial, melanoma nodular, melanoma lentiginoso acral e melanoma lentigo maligno. Os melanomas cutâneos podem surgir de nevos melanocíticos ou displásicos adquiridos ou congênitos. Os melanomas também podem surgir em outros locais anatômicos, incluindo o sistema gastrointestinal, olhos, trato urinário e sistema reprodutivo. Os melanomas freqüentemente metastatizam para os gânglios linfáticos, fígado, pulmões e cérebro.
Introdução
O que você precisa saber de cara
Tumor maligno, geralmente agressivo, composto por melanócitos neoplásicos atípicos. Na maioria das vezes, os melanomas surgem na pele (melanomas cutâneos) e incluem os seguintes subtipos histológicos: melanoma extensivo superficial, melanoma nodular, melanoma lentiginoso acral e melanoma lentigo maligno. Os melanomas cutâneos podem surgir de nevos melanocíticos ou displásicos adquiridos ou congênitos. Os melanomas também podem surgir em outros locais anatômicos, incluindo o sistema gastrointestinal, olhos, trato urinário e sistema reprodutivo. Os melanomas freqüentemente metastatizam para os gânglios linfáticos, fígado, pulmões e cérebro.
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 17 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 29 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
15 genes identificados com associação a esta condição.
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are ma
CytoplasmNucleusNucleus membrane
Melanoma, cutaneous malignant 3
A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but may also involve other sites.
Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:31073061). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:31073061). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:31073061). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, t
Cell membraneCytoplasm
Hypocalciuric hypercalcemia, familial 2
A form of hypocalciuric hypercalcemia, a disorder of mineral homeostasis that is transmitted as an autosomal dominant trait with a high degree of penetrance. It is characterized biochemically by lifelong elevation of serum calcium concentrations and is associated with inappropriately low urinary calcium excretion and a normal or mildly elevated circulating parathyroid hormone level. Hypermagnesemia is typically present. Affected individuals are usually asymptomatic and the disorder is considered benign. However, chondrocalcinosis and pancreatitis occur in some adults.
Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:34556863, PubMed:35672283, PubMed:37991948). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:37991948). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:37991948). The alpha subunit has a low GTPase activity
Cell membraneGolgi apparatusNucleusNucleus membrane
Capillary malformations, congenital
A form of vascular malformations that are present from birth, tend to grow with the individual, do not regress spontaneously, and show normal rates of endothelial cell turnover. Capillary malformations are distinct from capillary hemangiomas, which are highly proliferative lesions that appear shortly after birth and show rapid growth, slow involution, and endothelial hypercellularity.
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein
CytoplasmNucleus
Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus
NucleusChromosome, telomere
Tumor predisposition syndrome 3
An autosomal dominant disorder characterized by an increased risk for the development of various types of benign and malignant neoplasms throughout life, with age-dependent penetrance. Affected individuals can develop neoplasms involving epithelial, mesenchymal, and neuronal tissues, as well as lymphoid and myeloid cancers. The disorder is associated with elongated telomeres.
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest
Cytoplasm
Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310, PubMed:36104565). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing
NucleusNucleus speckle
Transcription factor that acts as a master regulator of melanocyte survival and differentiation as well as melanosome biogenesis (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoter of pigmentation genes, such as tyrosinase (TYR) (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Involved in the cellular response to amino acid availability by acting down
NucleusCytoplasmLysosome membrane
Waardenburg syndrome 2A
WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1.
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated
Nucleus
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repr
NucleusCytoplasmChromosomeChromosome, telomere
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-de
Nucleus, nucleolusNucleus, nucleoplasmNucleusChromosome, telomereCytoplasmNucleus, PML body
Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5 (By similarity). May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity)
Cell junction, tight junctionCell membrane
Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4
Cell membrane
G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha, beta, and gamma-MSH) and adrenocorticotropic hormone/ACTH, which are peptide products of the POMC precursor protein (PubMed:11442765, PubMed:11707265, PubMed:1325670, PubMed:1516719, PubMed:8463333). Upon activation, MC1R couples with the G(s) protein, stimulating adenylate cyclase and activating the cAMP-dependent signaling pathway. This activation promotes melanogenesis, resulting in the production of eumelanin (blac
Cell membrane
Melanoma, cutaneous malignant 5
A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but may also involve other sites.
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of P
NucleusChromosome, telomere
Dyskeratosis congenita, autosomal dominant, 6
A form of dyskeratosis congenita, a rare multisystem disorder caused by defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy.
Variantes genéticas (ClinVar)
182 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
69 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
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Publicações mais relevantes
Mostrando amostra de 96 publicações de um total de 72.330
Insights into RAS-driven melanoma and its therapeutic implications.
O melanoma com mutações no gene NRAS, que afeta 15-25% dos casos cutâneos, é atualmente tratado principalmente com imunoterapia anti-PD-1, já que os inibidores de MEK demonstraram benefício clínico limitado. Contudo, há um futuro promissor com diversas novas terapias em desenvolvimento, incluindo combinações de drogas, inibidores diretos de RAS e até vacinas específicas para as mutações. Para médicos e pacientes, é crucial que o tratamento seja cada vez mais personalizado e guiado por biomarcadores para otimizar os resultados e a gestão desta doença.
🇧🇷 traduzidoIntraepithelial Penile Lesions.
Este artigo descreve lesões intraepiteliais penianas, que incluem desde condições não-neoplásicas como condilomas (geralmente associados ao HPV) até lesões pré-neoplásicas, como a Neoplasia Intraepitelial Peniana (PeIN). A PeIN é crucial para médicos e pacientes devido ao seu potencial de progressão para câncer, sendo na Europa frequentemente associada ao HPV ou, em outros casos, a fatores como inflamações crônicas; e, embora raros, melanomas in situ primários do pênis também são descritos.
🇧🇷 traduzidoGlobal burden of lower respiratory infections and aetiologies, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
As infecções respiratórias inferiores (IRIs) continuam sendo a principal causa infecciosa de morte global, afetando desproporcionalmente crianças menores de 5 anos e adultos com mais de 70. O *Streptococcus pneumoniae* é o patógeno mais letal, mas o estudo também aponta para a importância crescente de micobactérias não tuberculosas e *Aspergillus spp*. Para médicos e pacientes, é crucial que o acesso equitativo a vacinas (incluindo novas para vírus sincicial respiratório), diagnóstico precoce e tratamentos eficazes seja ampliado, especialmente em regiões de alta mortalidade como a África Subsaariana, para sustentar os avanços na saúde infantil e abordar a vulnerabilidade crescente em idosos.
🇧🇷 traduzidoGlobal, regional, and national burden of chronic kidney disease in adults, 1990-2023, and its attributable risk factors: a systematic analysis for the Global Burden of Disease Study 2023.
A Doença Renal Crônica (DRC) é um grave e crescente problema de saúde global, afetando 788 milhões de adultos em 2023, sendo a nona principal causa de morte e a 12ª de incapacidade mundial. Para pacientes e médicos, é crucial saber que a DRC eleva significativamente o risco de mortes cardiovasculares e está fortemente ligada a fatores controláveis como glicose alta no sangue, obesidade e pressão arterial elevada. Isso sublinha a necessidade urgente de melhor rastreamento, prevenção e controle desses fatores para mitigar a progressão da doença e melhorar os resultados dos pacientes.
🇧🇷 traduzidoGlobal burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
Este estudo, o Global Burden of Disease Study 2023 (GBD 2023), oferece uma análise abrangente das causas de morte global entre 1990 e 2023, revelando que a idade média de morte aumentou significativamente. Apesar do impacto temporário da COVID-19 nas classificações, doenças cardíacas e AVC continuam sendo as principais causas, enquanto houve progresso em reduzir algumas infecciosas e um aumento das doenças não-transmissíveis (DNTs) em regiões de baixa renda. Para pacientes e profissionais de saúde, este estudo sublinha a necessidade de sistemas de saúde robustos e intervenções focadas para reduzir a mortalidade prematura e as grandes disparidades globais, embora o resumo fornecido não detalhe dados específicos sobre melanoma.
🇧🇷 traduzidoPublicações recentes
Acral Melanoma Following Trauma: A Systematic Review and Meta-Analysis.
📖 RevisãoJI-CJ002 and Dabrafenib Combination Enhances Antitumor Activity in Melanoma Associated With the Downregulation of B7-H3.
The relevance of membrane lipid composition in exosome-based precision dermatology.
Setmelanotide in Bardet-Biedl Syndrome: A Case Report.
💬 OpiniãoMelanoma of Unknown Primary Presenting as a Renal Mass: A Case Report.
📖 Revisão📚 EuropePMCmostrando 96
Insights into RAS-driven melanoma and its therapeutic implications.
Cancer treatment reviewsIntraepithelial Penile Lesions.
Advances in anatomic pathologyGlobal burden of lower respiratory infections and aetiologies, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
The Lancet. Infectious diseasesIdentification of a novel PRUNE2::NTRK2 gene fusion in soft tissue sarcoma patients-friend or foe? Case series.
Therapeutic advances in medical oncologyRadiotherapy of sinonasal cancers: 2025 update.
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologiqueGlobal, regional, and national burden of chronic kidney disease in adults, 1990-2023, and its attributable risk factors: a systematic analysis for the Global Burden of Disease Study 2023.
Lancet (London, England)Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
Lancet (London, England)Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
Lancet (London, England)Consider the unexpected! An overlooked, elusive, rare but dramatic diagnosis: anorectal melanoma.
Updates in surgeryAssociation between ovarian sex cord-stromal tumors and non-hormone-sensitive cancers: A nationwide nested cohort study.
Journal of gynecology obstetrics and human reproductionCombined immunotherapy with nivolumab and ipilimumab with and without sequential or concomitant stereotactic radiotherapy in patients with melanoma brain metastasis: An international retrospective study.
European journal of cancer (Oxford, England : 1990)Risk of cancer in patients with rheumatoid arthritis under tocilizumab: Data from the French national registry REGATE.
Joint bone spineReal-World Evidence of the Prevalence of Driver Mutations in Anorectal Melanoma.
Molecular diagnosis & therapyNovel Variants in Medium and Low Penetrance Predisposing Genes in a Hungarian Malignant Melanoma Cohort With Increased Risk.
Pigment cell & melanoma researchDiagnostic trajectories of patients with rare cancer in the Netherlands: results from a nationwide cross-sectional survey.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in CancerPathogenic Germline Variants in Uveal Melanoma Driver and BAP1-Associated Genes in Finnish Patients with Uveal Melanoma.
Pigment cell & melanoma researchProtein-truncating and rare missense variants in ATM and CHEK2 and associations with cancer in UK Biobank whole-exome sequence data.
Journal of medical geneticsSpectrum and Frequency of BRAF Mutations in Skin Melanomas in the Dalmatian Region of Croatia.
Acta dermatovenerologica Croatica : ADCVimseltinib versus placebo for tenosynovial giant cell tumour (MOTION): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.
Lancet (London, England)Recommendations for the use of next-generation sequencing (NGS) for patients with advanced cancer in 2024: a report from the ESMO Precision Medicine Working Group.
Annals of oncology : official journal of the European Society for Medical OncologySkin Changes in Suspected Lyme Disease.
Acta dermatovenerologica Croatica : ADCComprehensive genomic profiling on metastatic Melanoma: results from a network screening from 7 Italian Cancer Centres.
Journal of translational medicineSequential immunotherapy and targeted therapy for metastatic BRAF V600 mutated melanoma: 4-year survival and biomarkers evaluation from the phase II SECOMBIT trial.
Nature communicationsClinical practice guidelines for the diagnosis and surveillance of BAP1 tumour predisposition syndrome.
European journal of human genetics : EJHGQuality indicators: completeness, validity and timeliness of cancer registry data contributing to the European Cancer Information System.
Frontiers in oncologyGenomic profiling of a metastatic anaplastic melanocytic neuroectodermal tumor arising from a mature thymic teratoma as part of a mediastinal germ cell tumor.
Cold Spring Harbor molecular case studies'Get Data Out' Skin: national cancer registry incidence and survival rates for all registered skin tumour groups for 2013-2019 in England.
The British journal of dermatologyCINSARC in high-risk soft tissue sarcoma patients treated with neoadjuvant chemotherapy: Results from the ISG-STS 1001 study.
Cancer medicineThe Transcriptional Landscape of BRAF Wild Type Metastatic Melanoma: A Pilot Study.
International journal of molecular sciencesSingle-agent anti-PD-1 or combined with ipilimumab in patients with mucosal melanoma: an international, retrospective, cohort study.
Annals of oncology : official journal of the European Society for Medical OncologyNationwide multidisciplinary consensus on the clinical management of Merkel cell carcinoma: a Delphi panel.
Journal for immunotherapy of cancerGlobal Burden of Cutaneous Melanoma in 2020 and Projections to 2040.
JAMA dermatologyClinical features, molecular characteristics and surgical management of primary penile mucosal melanoma based on the European Association of Urology Penile Cancer Guidelines.
Melanoma researchGastrointestinal stromal tumours: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Annals of oncology : official journal of the European Society for Medical OncologyBone sarcomas: ESMO-EURACAN-GENTURIS-ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up.
Annals of oncology : official journal of the European Society for Medical OncologySoft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up☆.
Annals of oncology : official journal of the European Society for Medical OncologyEuropean Reference Network for rare adult solid cancers, statement and integration to health care systems of member states: a position paper of the ERN EURACAN.
ESMO openCaucasians with acral lentiginous melanoma have the same outcome as patients with stage- and limb-matched superficial spreading melanoma.
Journal of cancer research and clinical oncologySystemic therapies in advanced epithelioid haemangioendothelioma: A retrospective international case series from the World Sarcoma Network and a review of literature.
Cancer medicineAvelumab treatment in Italian patients with metastatic Merkel cell carcinoma: experience from an expanded access program.
Journal of translational medicineA systematic review and meta-analysis of neurotrophic tyrosine receptor kinase gene fusion frequencies in solid tumors.
Therapeutic advances in medical oncologyThe surgical treatment of non-metastatic melanoma in a Clinical National Melanoma Registry Study Group (CNMR): a retrospective cohort quality improvement study to reduce the morbidity rates.
BMC cancerEfficacy of Electrochemotherapy in the Treatment of Cutaneous Melanoma Metastases and Rare Non-melanoma Skin Cancer.
Anticancer researchIncidence and Mortality of Second Primary Cancers in Danish Patients With Retinoblastoma, 1943-2013.
JAMA network openPreoperative radiotherapy plus surgery versus surgery alone for patients with primary retroperitoneal sarcoma (EORTC-62092: STRASS): a multicentre, open-label, randomised, phase 3 trial.
The Lancet. OncologySurvival outcomes of patients with advanced mucosal melanoma diagnosed from 2013 to 2017 in the Netherlands - A nationwide population-based study.
European journal of cancer (Oxford, England : 1990)Ano-uro-genital mucosal melanoma UK national guidelines.
European journal of cancer (Oxford, England : 1990)Germline loss-of-function variants in MBD4 are rare in Finnish patients with uveal melanoma.
Pigment cell & melanoma researchQuality of treatment and surgical approach for rectal gastrointestinal stromal tumour (GIST) in a large European cohort.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical OncologyIncidence and Survival of Patients With Conjunctival Melanoma in Europe.
JAMA ophthalmologyPhase 2 study of pembrolizumab in patients with advanced rare cancers.
Journal for immunotherapy of cancerIncidence and mortality for cutaneous squamous cell carcinoma: comparison across three continents.
Journal of the European Academy of Dermatology and Venereology : JEADVSystemic treatments in MDM2 positive intimal sarcoma: A multicentre experience with anthracycline, gemcitabine, and pazopanib within the World Sarcoma Network.
CancerA novel germline variant in the DOT1L gene co-segregating in a Dutch family with a history of melanoma.
Melanoma researchEvaluation of the contribution of germline variants in BRCA1 and BRCA2 to uveal and cutaneous melanoma.
Melanoma researchGenetic epidemiology of colorectal cancer and associated cancers.
MutagenesisFamilial aggregation of early-onset cancers.
International journal of cancerCombined analysis of keratinocyte cancers identifies novel genome-wide loci.
Human molecular geneticsComparison of quality of life between melanoma and non-melanoma skin cancer patients.
European journal of dermatology : EJDPopulation-based analysis of BAP1 germline variations in patients with uveal melanoma.
Human molecular geneticsDefining and listing very rare cancers of paediatric age: consensus of the Joint Action on Rare Cancers in cooperation with the European Cooperative Study Group for Pediatric Rare Tumors.
European journal of cancer (Oxford, England : 1990)Risk of cancer in children and young adults conceived by assisted reproductive technology.
Human reproduction (Oxford, England)POT1 germline mutations but not TERT promoter mutations are implicated in melanoma susceptibility in a large cohort of Spanish melanoma families.
The British journal of dermatologyBRCA1/2 mutations are not a common cause of malignant melanoma in the Polish population.
PloS oneCombining common genetic variants and non-genetic risk factors to predict risk of cutaneous melanoma.
Human molecular geneticsIncidence and characteristics of thick second primary melanomas: a study of the German Central Malignant Melanoma Registry.
Journal of the European Academy of Dermatology and Venereology : JEADVMerkel cell carcinoma: Clinical outcome and prognostic factors in 351 patients.
Journal of surgical oncologyCrizotinib in patients with advanced, inoperable inflammatory myofibroblastic tumours with and without anaplastic lymphoma kinase gene alterations (European Organisation for Research and Treatment of Cancer 90101 CREATE): a multicentre, single-drug, prospective, non-randomised phase 2 trial.
The Lancet. Respiratory medicineGermline Variants in the POT1-Gene in High-Risk Melanoma Patients in Austria.
G3 (Bethesda, Md.)Pediatric patients with cutaneous melanoma: A European study.
Pediatric blood & cancerTreatment of conjunctival melanoma in a Dutch referral centre.
The British journal of ophthalmologyClinical characteristics and outcome of 60 pediatric patients with malignant melanoma registered with the German Pediatric Rare Tumor Registry (STEP).
Klinische PadiatrieLessons of a day hospital: Comprehensive assessment of patients with albinism in a European setting.
Pigment cell & melanoma researchUltrasound-based follow-up does not increase survival in early-stage melanoma patients: A comparative cohort study.
European journal of cancer (Oxford, England : 1990)Satisfaction of mountain guides with high sun protection as a tool to prevent non-melanoma skin cancer.
Journal of the European Academy of Dermatology and Venereology : JEADVSinonasal mucosal melanoma: A 44-case study and literature analysis.
European annals of otorhinolaryngology, head and neck diseasesDo outdoor workers know their risk of NMSC? Perceptions, beliefs and preventive behaviour among farmers, roofers and gardeners.
Journal of the European Academy of Dermatology and Venereology : JEADVPrognostic role of the histological subtype of melanoma on the hands and feet in Caucasians.
Melanoma researchRisk of other Cancers in Families with Melanoma: Novel Familial Links.
Scientific reportsPrognostic value of two tumour staging classifications in patients with sinonasal mucosal melanoma.
European annals of otorhinolaryngology, head and neck diseasesThe MITF, p.E318K Variant, as a Risk Factor for Pheochromocytoma and Paraganglioma.
The Journal of clinical endocrinology and metabolismAssociations between childhood height and morphologically different variants of melanoma in adulthood.
European journal of cancer (Oxford, England : 1990)Risk of invasive melanoma in patients with rheumatoid arthritis treated with biologics: results from a collaborative project of 11 European biologic registers.
Annals of the rheumatic diseasesConjunctival malignant melanoma in Denmark: epidemiology, treatment and prognosis with special emphasis on tumorigenesis and genetic profile.
Acta ophthalmologicaThe occurrence of non-melanoma malignant skin lesions and non-cutaneous squamous-cell carcinoma among metastatic melanoma patients: an observational cohort study in Denmark.
BMC cancerMultiple primary melanomas (MPMs) and criteria for genetic assessment: MultiMEL, a multicenter study of the Italian Melanoma Intergroup.
Journal of the American Academy of DermatologyA Retrospective Review of Conjunctival Melanoma Presentation, Treatment, and Outcome and an Investigation of Features Associated With BRAF Mutations.
JAMA ophthalmologyTrends in survival for teenagers and young adults with cancer in the UK 1992-2006.
European journal of cancer (Oxford, England : 1990)Comparison of melanoma incidence and trends among youth under 25 years in Australia and England, 1990-2010.
International journal of cancerHigh nevus counts confer a favorable prognosis in melanoma patients.
International journal of cancerMolecular characterization of melanoma cases in Denmark suspected of genetic predisposition.
PloS one443 paediatric cases of malignant melanoma registered with the German Central Malignant Melanoma Registry between 1983 and 2011.
European journal of cancer (Oxford, England : 1990)The forthcoming inexorable decline of cutaneous melanoma mortality in light-skinned populations.
European journal of cancer (Oxford, England : 1990)Sinonasal malignancies in Sweden 1960-2010; a nationwide study of the Swedish population.
RhinologyCancer-specific variation in emergency presentation by sex, age and deprivation across 27 common and rarer cancers.
British journal of cancerThe MC1R melanoma risk variant p.R160W is associated with Parkinson disease.
Annals of neurologyAssociações
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Referências e fontes
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Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Insights into RAS-driven melanoma and its therapeutic implications.
- Intraepithelial Penile Lesions.
- Global burden of lower respiratory infections and aetiologies, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
- Global, regional, and national burden of chronic kidney disease in adults, 1990-2023, and its attributable risk factors: a systematic analysis for the Global Burden of Disease Study 2023.
- Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
- Acral Melanoma Following Trauma: A Systematic Review and Meta-Analysis.
- JI-CJ002 and Dabrafenib Combination Enhances Antitumor Activity in Melanoma Associated With the Downregulation of B7-H3.
- The relevance of membrane lipid composition in exosome-based precision dermatology.
- Setmelanotide in Bardet-Biedl Syndrome: A Case Report.
- Melanoma of Unknown Primary Presenting as a Renal Mass: A Case Report.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:411533(Orphanet)
- MONDO:0005105(MONDO)
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
