Uma doença de fígado rara, caracterizada pelo acúmulo de bile dentro do fígado e pela piora do funcionamento do fígado em pacientes que recebem alimentação pela veia por muito tempo (os primeiros sinais podem surgir em apenas duas semanas depois de começar esse tipo de alimentação). Essa condição é mais comum em recém-nascidos e geralmente melhora quando o paciente passa a se alimentar pela boca ou por sonda, embora em casos mais sérios possa levar a fibrose (endurecimento) do fígado, cirrose e hipertensão portal (aumento da pressão em veias importantes do fígado).
Introdução
O que você precisa saber de cara
Uma doença de fígado rara, caracterizada pelo acúmulo de bile dentro do fígado e pela piora do funcionamento do fígado em pacientes que recebem alimentação pela veia por muito tempo (os primeiros sinais podem surgir em apenas duas semanas depois de começar esse tipo de alimentação). Essa condição é mais comum em recém-nascidos e geralmente melhora quando o paciente passa a se alimentar pela boca ou por sonda, embora em casos mais sérios possa levar a fibrose (endurecimento) do fígado, cirrose e hipertensão portal (aumento da pressão em veias importantes do fígado).
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Entender a doença
Do básico ao detalhe, leia no seu ritmo
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 12 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 22 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Colestase associada a nutrição parenteral
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21 ensaios clínicos encontrados, 2 ativos.
Publicações mais relevantes
Response to Letter to the Editor: Association between mixed fatty acid emulsion and parenteral nutrition-associated cholestasis in extremely low-birth-weight infants: A retrospective cohort study.
Fecal Microbiome and Bile Acid Profiles Differ in Preterm Infants with Parenteral Nutrition-associated Cholestasis.
Parenteral nutrition (PN)-associated cholestasis (PNAC) is frequently diagnosed in premature infants; however, not all PN-exposed infants develop PNAC. We propose that, in premature infants receiving PN and varying amounts of enteral feeds, differences in the gut microbiome and fecal bile acid content are associated with PNAC development. This study aimed to examine the fecal microbiome and bile acid content of premature infants on PN to determine if there is a relationship with the development of PNAC. Twenty-two preterm infants had serial bilirubin measurements and fecal samples collected during their neonatal intensive care unit admission. Fecal samples underwent 16S rRNA gene sequencing and bile acid analysis. Binomial regression, adjusting for postmenstrual age with feed amount as a moderator, was used to assess the impact of the fecal microbiome and bile acids on PNAC development. Cholestatic patients (n = 11) had greater PN and antibiotic exposure (p = 0.020; p = 0.010) and longer neonatal intensive care unit stays (p = 0.0038) than non-cholestatic patients. Microbiome richness was higher in non-cholestatic infants (p < 2E-16), with no difference in β diversity (p = 1.0). Cholestatic infants had a significantly higher abundance of Proteobacteria and Fusobacteriota and a lower abundance of Bacteroidota (p < 2E-16). Akkermansia was abundant in all infants on low feeds; as feed volume increased, Akkermansia abundance significantly increased in non-cholestatic infants (p < 2E-16). Bile acid analysis demonstrated significantly lower deoxycholic acid concentrations in cholestatic infants (p < 2E-16). Metagenomic analysis revealed an increase in Proteobacteria requiring augmented stress responses in non-cholestatic infants. This is the first study to directly explore the relationship between PNAC susceptibility, the microbiome, and fecal bile acids in preterm infants. The microbiome and bile acid patterns identified here may inform the development of targeted therapeutics for this vulnerable population.
Predictive role of parenteral and enteral nutrition duration in parenteral nutrition-associated cholestasis among very preterm infants.
Parenteral nutrition-associated cholestasis (PNAC) is common among very and extremely preterm infants (VPT). This study aims to investigate the relationship between the duration of parenteral nutrition (PN), enteral nutrition (EN), and the PN/EN ratio and the occurrence of PNAC in VPT, with the goal of providing a basis for the early identification of high-risk infants in clinical practice. A total of 230 VPT were retrospectively enrolled and divided into two groups based on the occurrence of PNAC. Baseline characteristics such as gestational age, sex, and birth weight, as well as clinical features, were compared between groups. Multivariable logistic regression was used to analyze the association between the duration of enteral nutrition (EN), parenteral nutrition (PN), and the development of PNAC. Interaction effects between PN, EN, the PN/EN ratio, and clinical variables were also explored. Restricted cubic spline (RCS) regression was employed to assess potential nonlinear relationships between PN, EN duration, PN/EN ratio, and PNAC. Predictive performance was evaluated using the area under the receiver operating characteristic curve (AUC). Infants in the PNAC group had significantly lower gestational age, birth weight, and Apgar scores compared to the non-PNAC group. In contrast, the incidence of premature rupture of membranes and mechanical ventilation was significantly higher. In VPT, longer PN duration, shorter EN duration, and a higher PN/EN ratio were significantly associated with increased risk of PNAC, showing linear or near-linear trends. ROC analysis indicated that the PN/EN ratio had better predictive performance for PNAC than either PN or EN duration alone. Interaction analysis revealed that the association between PN/EN and PNAC risk was stronger in infants with lower birth weight and lower 1-minute Apgar scores. Longer PN duration, shorter EN duration, and a higher PN/EN ratio are significant risk factors for PNAC in VPT. The PN/EN ratio demonstrated the best predictive accuracy. The association between PN/EN and PNAC was more pronounced in infants with lower birth weight and lower 1-minute Apgar scores.
[Clinical characteristics and risk factors for adverse outcomes in omphalocele].
Objective: To investigate the clinical characteristics of omphalocele, and to assess the risk factors associated with adverse outcomes. Methods: A retrospective cohort study was conducted. Clinical data of 224 patients diagnosed with omphalocele, who were hospitalized at Children's Hospital, Zhejiang University School of Medicine from January 2013 to December 2022, were collected. Based on their discharge outcomes, the patients were classified into 2 groups: favorable outcomes and unfavorable outcomes. χ2 test, continuity correction χ2 test, Fisher exact probability method, and Mann-Whitney U test were used for intergroup comparisons. Logistic regression analysis was performed to identify risk factors associated with adverse outcomes in omphalocele. Results: Among the 224 patients with omphalocele, 126 were male. A total of 208 patients (92.9%) had favorable outcomes, while 16 patients (7.1%) had unfavorable outcomes. In the unfavorable outcomes group, 14 patients had giant omphaloceles, while 100 patients had giant omphaloceles in the favorable outcomes group. The rates of herniation of more than 2 intra-abdominal organs in the hernial sac, congenital heart defects, patent ductus arteriosus, pulmonary hypertension, sepsis and infection of the hernial sac, were all higher in the unfavorable outcomes group compared to the favorable outcomes group (all P<0.05). Patients with unfavorable outcomes had longer mechanical ventilation time, duration of oxygen use, duration of parenteral nutrition, hospital stays, and higher rates of parenteral nutrition-associated cholestasis compared to those with favorable outcomes (all P<0.01). Multivariate Logistic regression analysis indicated that pulmonary hypertension (OR=9.39, 95%CI 1.20-73.32), sepsis (OR=8.59, 95%CI 1.32-55.86), and congenital heart defects (OR=6.55, 95%CI 1.11-38.73) were all independent risk factors for adverse outcomes in omphalocele (all P<0.05). Conclusions: Infants with omphalocele are prone to complications such as cardiovascular malformations, infections, and pulmonary hypertension. Adverse outcomes in omphalocele are associated with pulmonary hypertension, sepsis, and congenital heart defects. 目的： 探讨脐膨出的临床特征，评估脐膨出不良结局的相关危险因素。 方法： 回顾性队列研究，收集2013年1月至2022年12月在浙江大学医学院附属儿童医院因脐膨出住院治疗的224例患儿临床资料。根据患儿出院时状况分为预后良好及预后不良2组，采用χ2检验、连续校正χ2检验、Fisher确切概率法、Mann-Whitney U 检验比较两组患儿的疾病特点及诊治情况。通过Logistic回归分析寻找与脐膨出不良结局相关的危险因素。 结果： 224例脐膨出患儿中男126例，208例（92.9%）预后良好，16例（7.1%）预后不良。预后不良组患儿中巨型脐膨出14例，预后良好组患儿中巨型脐膨出100例。预后不良组疝囊中疝入2个以上腹腔脏器、合并心脏畸形、动脉导管未闭、肺动脉高压、败血症、疝囊表面感染的比例均高于预后良好组（均P<0.05）。预后不良组患儿有创机械通气、氧疗应用、静脉营养应用和总住院时间均长于预后良好组，出现静脉营养相关胆汁淤积的比例高于预后良好组（均P<0.01）。多因素Logistic回归分析显示，肺动脉高压（OR=9.39，95%CI 1.20~73.32）、败血症（OR=8.59，95%CI 1.32~55.86）、合并心脏畸形（OR=6.55，95%CI 1.11~38.73）均为脐膨出不良结局的独立危险因素（均P<0.05）。 结论： 脐膨出易合并心脏畸形、败血症、肺动脉高压等，不良结局的危险因素包括肺动脉高压、败血症及合并心脏畸形。.
MRPL35 Attenuates Neonatal Parenteral Nutrition-Associated Cholestasis by Modulating the ROS/JNK/NF-κB Pathway.
This study aimed to elucidate the role of the MRPL35/ROS/JNK/NF-κB signaling pathway in the pathogenesis of neonatal parenteral nutrition-associated cholestasis (PNAC) to identify underlying mechanisms and potential therapeutic targets. The study employed both human and animal models. Neonates receiving parenteral nutrition for at least 2 weeks were divided into PNAC (n=10) and control groups (n=13). A PNAC model was established in male Sprague-Dawley rats (parenteral nutrition for 14 days, n=6/group), with interventions including adenovirus-mediated MRPL35 overexpression and N-acetylcysteine (NAC) treatment. Inflammatory markers, oxidative stress indicators, and signaling pathway activation were assessed using ELISA, immunohistochemistry, qRT-PCR, and Western blotting. Clinically, neonates with PNAC exhibited elevated serum levels of AST, DBil, TBA, TNF-α, and IL-1β, along with reduced levels of anti-inflammatory cytokines (IL-4, IL-10), increased ROS, and higher apoptosis in peripheral blood mononuclear cells (PBMCs). MRPL35 expression was significantly downregulated and JNK and NF-κB pathways were activated. In the animal model, PNAC rats showed severe liver injury, elevated TNF-α, IL-1β and ROS in hepatocytes, and higher hepatocyte apoptosis; the expression of MRPL35 mRNA was significantly downregulated. Overexpression of MRPL35 reduced JNK/NF-κB activation, inflammatory cytokines, oxidative stress and liver injury, effects that were enhanced by co-treatment with N-acetylcysteine (NAC). The MRPL35/ROS/JNK/NF-κB signaling pathway plays a critical role in the pathogenesis of PNAC. Targeting MRPL35 is expected to alleviate liver injury by blocking mitochondrial ROS signaling, offering a novel precision treatment model targeting the mitochondrial-inflammation axis for PNAC.
Publicações recentes
Fecal Microbiome and Bile Acid Profiles Differ in Preterm Infants with Parenteral Nutrition-associated Cholestasis.
MRPL35 Attenuates Neonatal Parenteral Nutrition-Associated Cholestasis by Modulating the ROS/JNK/NF-κB Pathway.
Predictive role of parenteral and enteral nutrition duration in parenteral nutrition-associated cholestasis among very preterm infants.
📚 EuropePMC141 artigos no totalmostrando 96
Fecal Microbiome and Bile Acid Profiles Differ in Preterm Infants with Parenteral Nutrition-associated Cholestasis.
Journal of clinical and translational hepatologyMRPL35 Attenuates Neonatal Parenteral Nutrition-Associated Cholestasis by Modulating the ROS/JNK/NF-κB Pathway.
Journal of inflammation researchPredictive role of parenteral and enteral nutrition duration in parenteral nutrition-associated cholestasis among very preterm infants.
Frontiers in pediatricsAssociation between mixed fatty acid emulsion and parenteral nutrition-associated cholestasis in extremely low-birth-weight infants: A retrospective cohort study.
JPEN. Journal of parenteral and enteral nutritionEssential fatty acid deficiency in children treated with long-term 100% fish-oil lipid injectable emulsion: A longitudinal descriptive cohort study.
JPEN. Journal of parenteral and enteral nutritionSemaphorin 7A Induces Liver Inflammation and Promotes Parenteral Nutrition-Associated Cholestasis via ITGβ1/NF-κB Pathway.
Archives of medical researchAssociation between multioil intravenous lipid emulsion and cholestasis in infants with gastrointestinal disorders: A retrospective cohort study.
JPEN. Journal of parenteral and enteral nutritionFish oil lipid emulsion compared with soybean oil lipid emulsion in pediatric patients with parenteral nutrition-associated cholestasis: A cost-effectiveness study.
JPEN. Journal of parenteral and enteral nutrition[Clinical characteristics and risk factors for adverse outcomes in omphalocele].
Zhonghua er ke za zhi = Chinese journal of pediatrics[Analysis of the etiology and clinical indicators of infantile cholestasis].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatologyAssociation between SMOF lipid and parenteral nutrition-associated cholestasis compared with Intralipid in extremely low birth weight infants: A retrospective cohort study.
JPEN. Journal of parenteral and enteral nutritionUnderstanding the dynamics of biochemical liver markers in preterm infants with parenteral nutrition-associated cholestasis may prevent unnecessary invasive examinations.
Acta paediatrica (Oslo, Norway : 1992)Intravenous lipid emulsions designed to meet preterm infant requirements increase plasma and tissue levels of docosahexaenoic acid and arachidonic acid in mice.
Clinical nutrition (Edinburgh, Scotland)Recovery from parenteral nutrition-associated cholestasis takes approximately two months in very low birth weight infants.
Acta paediatrica (Oslo, Norway : 1992)Prevention of Parenteral Nutrition-associated Cholestasis Using Reduced Dose Soybean Lipid Emulsion: A Multicenter Randomized Trial.
Journal of pediatric surgeryHyperglycemia in pregnancy did not worsen the short-term outcomes of very preterm infants: a propensity score matching study.
Frontiers in pediatricsThe role of nutrition in analysis of risk factors and short-term outcomes for late-onset necrotizing enterocolitis among very preterm infants: a nationwide, multicenter study in China.
BMC pediatricsUrsodeoxycholic acid for preventing parenteral nutrition-associated cholestasis in neonates: A systematic review and meta-analysis.
Fundamental & clinical pharmacologyAssociation between two different lipid injectable emulsions and parenteral nutrition-associated cholestasis in very low birth weight infants: A retrospective cohort study.
JPEN. Journal of parenteral and enteral nutritionLRH-1 agonist DLPC through STAT6 promotes macrophage polarization and prevents parenteral nutrition-associated cholestasis in mice.
Hepatology (Baltimore, Md.)[Comparison of the impact of different fat emulsions on clinical outcomes in preterm infants with varying duration of parenteral nutrition: a randomized controlled multicenter study].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsExpression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition.
PloS onePublisher Correction: Pharmacologic inhibition of HNF4α prevents parenteral nutrition associated cholestasis in mice.
Scientific reports[Value of the combined use of aminotransferase-to-platelet ratio index and total bile acid for predicting parenteral nutrition-associated cholestasis in preterm infants with gestational age <34 weeks].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsAnalysis of risk factors for parenteral nutrition-associated cholestasis in preterm infants: a multicenter observational study.
BMC pediatricsPharmacologic inhibition of HNF4α prevents parenteral nutrition associated cholestasis in mice.
Scientific reportsComparison of Two Lipid Emulsions on the Incidence of Parenteral Nutrition Associated Cholestasis in Neonates.
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGEffects of mixed oil emulsion on short-term clinical outcomes in premature infants: A prospective, multicenter, randomized controlled trial.
European journal of clinical nutrition[Association between early parenteral nutrition and the development of bronchopulmonary dysplasia in preterm infants].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsDilemmas in the delivery of intravenous lipid emulsions and approach to hypertriglyceridemia in very preterm and low birth weight infants.
Journal of perinatology : official journal of the California Perinatal AssociationStat3 role in the protective effect of FXR Agonist in parenteral nutrition-associated cholestasis.
Hepatology communicationsNeonatal Intensive Care Unit Mixed Lipid Emulsion Use Associated With Reduced Cholestasis at Discharge in Surgical Patients.
The Journal of surgical researchHome Parenteral Nutrition for Children: What Are the Factors Indicating Dependence and Mortality?
NutrientsEfficacy and safety of ursodeoxycholic acid in children with cholestasis: A systematic review and meta-analysis.
PloS oneDexamethasone may affect the occurrence of parenteral nutrition-associated cholestasis in preterm neonates.
Frontiers in pediatricsNeurodevelopmental Outcome of Extremely Low Birth Weight Infants with Cholestasis at 12 and 24 Months.
NeonatologyEtiology of neonatal cholestasis after emerging molecular diagnostics.
Translational pediatricsFish oil-containing lipid emulsions prevention on parenteral nutrition-associated cholestasis in very low birth weight infants: a meta-analysis.
World journal of pediatrics : WJPUrsodeoxycholic Acid and SMOFlipid for Treating Parenteral Nutrition Associated Cholestasis in Infants.
CureusFecal sphingolipids predict parenteral nutrition-associated cholestasis in the neonatal intensive care unit.
JPEN. Journal of parenteral and enteral nutritionMdr3 gene mutation in preterm infants with parenteral nutrition-associated cholestasis.
Molecular genetics & genomic medicineNeonatal Cholestasis: Updates on Diagnostics, Therapeutics, and Prevention.
NeoReviewsInterrupting tumor necrosis factor-alpha signaling prevents parenteral nutrition-associated cholestasis in mice.
JPEN. Journal of parenteral and enteral nutritionPharmacologic activation of hepatic farnesoid X receptor prevents parenteral nutrition-associated cholestasis in mice.
Hepatology (Baltimore, Md.)Prevention and Management of Parenteral Nutrition-Associated Cholestasis and Intestinal Failure-Associated Liver Disease in the Critically Ill Infant.
World review of nutrition and dieteticsNF-κB Regulation of LRH-1 and ABCG5/8 Potentiates Phytosterol Role in the Pathogenesis of Parenteral Nutrition-Associated Cholestasis.
Hepatology (Baltimore, Md.)[Analysis of related factors of poor prognosis in children with parenteral nutrition-associated cholestasis].
Zhonghua wei zhong bing ji jiu yi xueHuman induced pluripotent stem cell derived hepatocytes provide insights on parenteral nutrition associated cholestasis in the immature liver.
Scientific reportsIntravenous Lipid Emulsions in the Prevention and Treatment of Liver Disease in Intestinal Failure.
Nutrients[Clinical effect of multi-oil fat emulsion for parenteral nutrition support in extremely low birth weight infants].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsDepletion and enrichment of phytosterols in soybean oil lipid emulsions directly associate with serum markers of cholestasis in preterm parenteral nutrition-fed pigs.
JPEN. Journal of parenteral and enteral nutritionImpact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates.
NutrientsGrowth of Head Circumference and Body Length in Preterm Infants Receiving a Multicomponent vs a Soybean-Based Lipid Emulsion: A Randomized Controlled Trial.
JPEN. Journal of parenteral and enteral nutritionPrediction, identification and progression of histopathological liver disease activity in children with intestinal failure.
Journal of hepatologySMOFlipid vs Intralipid 20%: Effect of Mixed-Oil vs Soybean-Oil Emulsion on Parenteral Nutrition-Associated Cholestasis in the Neonatal Population.
JPEN. Journal of parenteral and enteral nutritionIntestinal failure-associated liver disease (IFALD): insights into pathogenesis and advances in management.
Hepatology internationalRisk factors of parenteral nutrition-associated cholestasis in very-low-birthweight infants.
Journal of paediatrics and child healthGram-negative Microbiota Blooms in Premature Twins Discordant for Parenteral Nutrition-associated Cholestasis.
Journal of pediatric gastroenterology and nutrition[Observation on the efficacy and complications of intravenous nutrition strategy in premature infants with birth weight < 1 500 g].
Zhonghua wei zhong bing ji jiu yi xueThe effectiveness of serum amyloid A for prediction of neonatal cholestasis associated with parenteral nutrition in premature infants.
The Turkish journal of pediatricsUse of Fish Oil Intravenous Lipid Emulsions as Monotherapy in the Pediatric Intestinal Failure Patient: Beyond the Package Insert.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral NutritionSepsis and bronchopulmonary dysplasia as potential risk factors for parenteral nutrition-associated cholestasis in neonates: a meta-analysis of retrospective studies.
Minerva pediatricsFecal Microbiomes in Premature Infants With and Without Parenteral Nutrition-Associated Cholestasis.
Journal of pediatric gastroenterology and nutritionPredictive value of the aspartate aminotransferase to platelet ratio index for parenteral nutrition associated cholestasis in extremely low birth weight infants.
BMC pediatricsEffects of cyclic parenteral nutrition on parenteral nutrition-associated cholestasis in newborns.
Asia Pacific journal of clinical nutritionTwo parenteral amino acid solutions and plasma levels of amino acids in the neonate: A randomized trial.
Nutrition (Burbank, Los Angeles County, Calif.)A case report of a challenging diagnosis of biliary atresia in a patient receiving total parenteral nutrition.
BMC pediatrics[mRNA expression of MDR3 gene in the blood of preterm infants with parenteral nutrition-associated cholestasis].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsIntravenous Lipid Emulsions in Infants: Is Balanced Better?
Neonatal network : NNSMOFlipid Protects Preterm Neonates against Perinatal Nutrition-Associated Cholestasis.
American journal of perinatologyCan mixed lipid emulsion prevent parenteral nutrition associated cholestasis?
Journal of perinatology : official journal of the California Perinatal AssociationEnteral fish oil supplementation in the resolution of parenteral nutrition associated cholestasis.
Journal of neonatal-perinatal medicinePlasma Phytosterol Half-Life and Levels Are Increased in Very Low Birth Weight Preterm Infants with Parenteral Nutrition-Associated Cholestasis.
LipidsFish oil-based lipid emulsion in the treatment of parenteral nutrition-associated cholestasis.
Italian journal of pediatricsMacrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis.
Nature communicationsCopper Supplementation in Premature Infants With Parenteral Nutrition-Associated Cholestasis.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral NutritionParenteral nutrition-associated cholestasis and triglyceridemia in surgical term and near-term neonates: A pilot randomized controlled trial of two mixed intravenous lipid emulsions.
Clinical nutrition ESPENA Mixed Lipid Emulsion for Prevention of Parenteral Nutrition Associated Cholestasis in Extremely Low Birth Weight Infants: A Randomized Clinical Trial.
The Journal of pediatricsUtility of hepatobiliary scintigraphy in diagnosing or excluding biliary atresia in premature neonates and full-term infants with conjugated hyperbilirubinemia who received parenteral nutrition.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal ObstetriciansPredictive Value of the Aspartate Aminotransferase to Platelet Ratio Index for Parenteral Nutrition-Associated Cholestasis in Premature Infants With Intestinal Perforation.
JPEN. Journal of parenteral and enteral nutritionMosapride combined with probiotics on gastrointestinal function and growth in premature infants.
Experimental and therapeutic medicineA pioneering study: oral clarithromycin treatment for feeding intolerance in very low birth weight preterm infants.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal ObstetriciansRetrospective Dual-Center Study of Parenteral Nutrition-Associated Cholestasis in Premature Neonates: 15 Years' Experience.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral NutritionHalf-life of plasma phytosterols in very low birth weight preterm infants on routine parenteral nutrition with vegetable oil-based lipid emulsions.
Clinical nutrition (Edinburgh, Scotland)Aggressive nutrition in extremely low birth weight infants: impact on parenteral nutrition associated cholestasis and growth.
PeerJPhytosterol Esterification is Markedly Decreased in Preterm Infants Receiving Routine Parenteral Nutrition.
LipidsManagement of short bowel syndrome in postoperative very low birth weight infants.
Seminars in fetal & neonatal medicineImprovement in Parenteral Nutrition-Associated Cholestasis With the Use of Omegaven in an Infant With Short Bowel Syndrome.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral NutritionRisk factor analysis of parenteral nutrition-associated cholestasis in extremely low birth weight infants.
Acta paediatrica (Oslo, Norway : 1992)Parenteral Nutrition-Associated Cholestasis in Very Low Birth Weight Infants: A Single Center Experience.
Pediatric gastroenterology, hepatology & nutritionLiquid chromatography-mass spectroscopy as a tool in the rapid diagnosis of biliary atresia: a pilot study.
Journal of pediatric surgeryAnalysis of mutations of MDR3 exons 9 and 23 in infants with parenteral nutrition-associated cholestasis.
Experimental and therapeutic medicineIncidence and Risk Factors of Parenteral Nutrition-Associated Cholestasis in Omani Neonates: Single centre experience.
Sultan Qaboos University medical journalComposition of parenteral nutrition solution affects the time of occurrence but not the incidence of cholestasis in surgical infants.
The Turkish journal of pediatricsParenteral fish oil-containing lipid emulsions may reverse parenteral nutrition-associated cholestasis in neonates: a systematic review and meta-analysis.
The Journal of nutritionInfluence of aggressive nutritional support on growth and development of very low birth weight infants.
Clinical and experimental obstetrics & gynecologyAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Response to Letter to the Editor: Association between mixed fatty acid emulsion and parenteral nutrition-associated cholestasis in extremely low-birth-weight infants: A retrospective cohort study.
- Fecal Microbiome and Bile Acid Profiles Differ in Preterm Infants with Parenteral Nutrition-associated Cholestasis.
- Predictive role of parenteral and enteral nutrition duration in parenteral nutrition-associated cholestasis among very preterm infants.
- [Clinical characteristics and risk factors for adverse outcomes in omphalocele].
- MRPL35 Attenuates Neonatal Parenteral Nutrition-Associated Cholestasis by Modulating the ROS/JNK/NF-κB Pathway.
- Letter to the Editor: Association between mixed fatty acid emulsion and parenteral nutrition-associated cholestasis in extremely low birthweight infants: A retrospective cohort study.
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- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
