Raras
Buscar doenças, sintomas, genes...
Síndrome hiperestimulação ovariana
ORPHA:64739CID-10 · N98.1CID-11 · GA32.0OMIM 608115DOENÇA RARA

Uma complicação da indução da ovulação no tratamento da infertilidade. É classificado pela gravidade dos sintomas que incluem aumento dos ovários, múltiplos folículos ovarianos; cistos ovarianos; ascite; e edema generalizado. A síndrome completa pode causar insuficiência renal, dificuldade respiratória e até morte. O aumento da permeabilidade capilar é causado pelas substâncias vasoativas, como os fatores de crescimento endotelial vascular, secretados pelos ovários excessivamente estimulados.

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Introdução

O que você precisa saber de cara

📋

Uma complicação da indução da ovulação no tratamento da infertilidade. É classificado pela gravidade dos sintomas que incluem aumento dos ovários, múltiplos folículos ovarianos; cistos ovarianos; ascite; e edema generalizado. A síndrome completa pode causar insuficiência renal, dificuldade respiratória e até morte. O aumento da permeabilidade capilar é causado pelas substâncias vasoativas, como os fatores de crescimento endotelial vascular, secretados pelos ovários excessivamente estimulados.

Pesquisas ativas
1 ensaio
75 total registrados no ClinicalTrials.gov
Publicações científicas
3.556 artigos
Último publicado: 2026 Dec
Medicamentos
12 registrados
PROGESTERONE, CETRORELIX, TRIPTORELIN

Tem tratamento?

12 medicamentos registrados
Ver detalhes, fases e interações →
PROGESTERONECETRORELIXTRIPTORELINCHORIOGONADOTROPIN ALFACABERGOLINELETROZOLEDEXAMETHASONEQUINAGOLIDEBROMOCRIPTINEMONTELUKAST

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
Adolescent
+ adult
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: N98.1
Você se identifica com essa condição?
O Raras está aqui pra te apoiar — com ou sem diagnóstico

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🫃
Digestivo
4 sintomas
🫁
Pulmão
1 sintomas
🧬
Pele e cabelo
1 sintomas
🦴
Ossos e articulações
1 sintomas
📏
Crescimento
1 sintomas
🫘
Rins
1 sintomas

+ 10 sintomas em outras categorias

Características mais comuns

90%prev.
Distensão abdominal
Muito frequente (99-80%)
90%prev.
Hirsutismo
Muito frequente (99-80%)
90%prev.
Ovários policísticos aumentados
Muito frequente (99-80%)
90%prev.
Náusea e vômito
Muito frequente (99-80%)
90%prev.
Dor abdominal
Muito frequente (99-80%)
90%prev.
Aumento do nível circulante de gonadotropina
Muito frequente (99-80%)
19sintomas
Muito frequente (10)
Frequente (3)
Ocasional (4)
Sem dados (2)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 19 características clínicas mais associadas, ordenadas por frequência.

Distensão abdominalAbdominal distention
Muito frequente (99-80%)90%
HirsutismoHirsutism
Muito frequente (99-80%)90%
Ovários policísticos aumentadosEnlarged polycystic ovaries
Muito frequente (99-80%)90%
Náusea e vômitoNausea and vomiting
Muito frequente (99-80%)90%
Dor abdominalAbdominal pain
Muito frequente (99-80%)90%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico3.556PubMed
Últimos 10 anos200publicações
Pico2025138 papers
Linha do tempo
2026Hoje · 2026🧪 2003Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

Genes associados

1 gene identificado com associação a esta condição. Padrão de herança: Not applicable.

FSHRFollicle-stimulating hormone receptorMajor susceptibility factor inTolerante
FUNÇÃO

G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (PubMed:24058690)

LOCALIZAÇÃO

Cell membrane

VIAS BIOLÓGICAS (2)
G alpha (s) signalling eventsHormone ligand-binding receptors
MECANISMO DE DOENÇA

Ovarian dysgenesis 1

An autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, poorly developed streak ovaries, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).

EXPRESSÃO TECIDUAL(Baixa expressão)
Testículo
3.1 TPM
Ovário
0.8 TPM
Fallopian Tube
0.1 TPM
Coração - Átrio
0.1 TPM
Artéria coronária
0.1 TPM
OUTRAS DOENÇAS (3)
ovarian dysgenesis 1ovarian hyperstimulation syndrome46 XX gonadal dysgenesis
HGNC:3969UniProt:P23945

Medicamentos e terapias

PROGESTERONEPhase 3

Mecanismo: Progesterone receptor agonist

CETRORELIXPhase 3

Mecanismo: Gonadotropin-releasing hormone receptor antagonist

TRIPTORELINPhase 3

Mecanismo: Gonadotropin-releasing hormone receptor agonist

CHORIOGONADOTROPIN ALFAPhase 3

Mecanismo: Luteinizing hormone/Choriogonadotropin receptor agonist

CABERGOLINEPhase 3

Mecanismo: Dopamine D2 receptor agonist

LETROZOLEPhase 3

Mecanismo: Cytochrome P450 19A1 inhibitor

DEXAMETHASONEPhase 3

Mecanismo: Glucocorticoid receptor agonist

QUINAGOLIDEPhase 2

Mecanismo: Dopamine D2 receptor agonist

BROMOCRIPTINEPhase 2

Mecanismo: D2-like dopamine receptor agonist

MONTELUKASTPhase 2

Mecanismo: Cysteinyl leukotriene receptor 1 antagonist

Ver mais no OpenTargets

Variantes genéticas (ClinVar)

66 variantes patogênicas registradas no ClinVar.

🧬 FSHR: NM_000145.4(FSHR):c.1633A>G (p.Ile545Val) ()
🧬 FSHR: GRCh37/hg19 2p16.3(chr2:49183378-49245850)x1 ()
🧬 FSHR: NM_000145.4(FSHR):c.1009T>C (p.Leu337=) ()
🧬 FSHR: NM_000145.4(FSHR):c.940_941del (p.Leu314fs) ()
🧬 FSHR: GRCh37/hg19 2p16.3(chr2:49195037-50625932)x1 ()
Ver todas no ClinVar

Classificação de variantes (ClinVar)

Distribuição de 61 variantes classificadas pelo ClinVar.

16
42
3
Patogênica (26.2%)
VUS (68.9%)
Benigna (4.9%)
VARIANTES MAIS SIGNIFICATIVAS
FSHR: NM_000145.4(FSHR):c.445C>T (p.Leu149Phe) [Likely pathogenic]
FSHR: NM_000145.4(FSHR):c.1109G>A (p.Trp370Ter) [Likely pathogenic]
FSHR: NM_000145.4(FSHR):c.1255G>C (p.Ala419Pro) [Likely pathogenic]
FSHR: NM_000145.4(FSHR):c.496G>T (p.Val166Leu) [Conflicting classifications of pathogenicity]
FSHR: NM_000145.4(FSHR):c.1022T>C (p.Val341Ala) [Conflicting classifications of pathogenicity]

Vias biológicas (Reactome)

2 vias biológicas associadas aos genes desta condição.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
Aprovado5
3Fase 311
2Fase 25
·Pré-clínico9
Medicamentos catalogadosEnsaios clínicos· 10 medicamentos · 20 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Síndrome hiperestimulação ovariana

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

1 pesquisa recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

75 ensaios clínicos encontrados, 1 ativos.

Distribuição por fase
NCT06333691 · Comparative Study Between Calcium Gluconate With Diosmin, Ca…Concluído
NA
NCT02686151 · The Letrozole Administration During Luteal PhaseUNKNOWN
PHASE3
NCT05362734 · Freeze All Strategy Versus Fresh Embryo Transfer After GnRH …Concluído
NCT05638529 · Dual Trigger" in IVF Patients at High Risk of Ovarian Hyper …UNKNOWN
PHASE4
NCT05588635 · Association Between Live Birth Rate and Serum Progesterone D…Concluído
NCT03794037 · Montelukast for Prevention & Treatment of OHSSSUSPENDED
PHASE2
NCT05198128 · Ovarian Hyperstimulation Syndrome Using Calcium InfusionUNKNOWN
NA
NCT03876145 · The Four Methods of Ovarian Stimulation in Patients With Pol…Concluído
NA
NCT04797338 · Gonadotropin Releasing Hormone Agonist (GnRHa) Versus Estrog…UNKNOWN
PHASE4
NCT02200952 · Luteal Phase Supplementation With Recombinant LH After GnRh …Concluído
NCT02610608 · Medical Assistance for the Procreation and Risk of Thrombosi…Encerrado
NCT04351126 · Management of Ovarian Hyperstimulation Syndrome as a State o…Concluído
PHASE2
NCT03996434 · Coasting Versus Antagonist Protocol in Patients at High Risk…Concluído
PHASE4
NCT02701452 · Ovarian Hyperstimulation Syndrome in Patients Triggered by G…Encerrado
NA
NCT01606709 · Gene Expression Profile After Gonadotropin Releasing Hormone…Encerrado
PHASE4
NCT01815138 · Co-administration of Low Dose hCG at the Time of GnRH Agonis…Concluído
PHASE4
NCT01535859 · Study of Cabergoline for Prevention of Ovarian Hyperstimulat…Concluído
PHASE3
NCT02620605 · The Influence of Timing of Cabergoline Initiation on Prevent…UNKNOWN
PHASE3
NCT03473613 · Cabergoline Versus Calcium Infusion in Ovarian Hyperstimulat…Concluído
PHASE3
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
1.459 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 1.459

#1

Transcriptomic Profiling Reveals Urokinase-Type Plasminogen Activator-Mediated Regulation of Metabolic Competence and Cumulus Expansion During Mouse Oocyte In Vitro Maturation.

International journal of molecular sciences2026 Feb 12

In vitro maturation (IVM) of mammalian oocytes is an essential fertility option for patients at risk of ovarian hyperstimulation syndrome or needing urgent fertility preservation. However, poor outcomes indicate a limited understanding of the molecular mechanisms behind cumulus cell expansion and extracellular matrix (ECM) remodeling. This study investigated the role of serum-derived urokinase-type plasminogen activator (PLAU) in mouse oocyte IVM. Immature cumulus-oocyte complexes from CD-1 mice were cultured with or without serum, and PLAU activity was blocked using 4-chlorophenylguanidine hydrochloride. Cumulus expansion, oocyte maturation, and cumulus cell transcriptomes were analyzed. Serum supplementation enhanced cumulus expansion and maturation, while absence of serum or PLAU inhibition hindered both processes. External PLAU partially rescued these issues under serum-free conditions. Transcriptome analysis demonstrated that inhibiting PLAU activity reduces the expression of ovulation- and metabolism-related genes, such as those involved in glycolysis and carbohydrate metabolism, while increasing genes related to vesicle-mediated transport. PLAU is crucial for cumulus expansion and metabolic regulation during IVM, affecting ECM remodeling and oocyte quality. Supporting IVM culture media with proteolytic and metabolic factors could improve outcomes in assisted reproduction.

#2

Vitamin D supplementation before in vitro fertilisation in women with polycystic ovary syndrome: multicentre, double blind, placebo controlled, randomised clinical trial.

BMJ (Clinical research ed.)2026 Feb 17

To evaluate whether vitamin D supplementation improves live birth rates in women with polycystic ovary syndrome undergoing in vitro fertilisation. Multicentre, double blind, placebo controlled, randomised clinical trial. 24 fertility centres in China. 876 participants with polycystic ovary syndrome undergoing in vitro fertilisation. Participants were randomised (1:1) to receive vitamin D 4000 IU/day or placebo before in vitro fertilisation for up to 90 days until the trigger day. The primary outcome was live birth after the first embryo transfer. Secondary outcomes included serum 25-hydroxyvitamin D (25-OHD) levels on trigger day, pregnancy outcomes, fertility outcomes, and adverse events including severe ovarian hyperstimulation syndrome. Of 876 participants randomised, 865 were included in the modified intention-to-treat analysis, with 435 in the vitamin D group and 430 in the placebo group. Baseline mean serum 25-OHD levels were 16.5±7.2 and 16.1±6.7 ng/mL in the vitamin D and placebo groups, respectively. On the day of triggering, the serum 25-OHD level was significantly higher in the vitamin D group than in the placebo group (32.3±11.2 v 18.2±7.6 ng/mL, adjusted mean difference 13.6, 95% confidence interval 10.9 to 16.3). 226 (52.0%) live births occurred in the vitamin D group and 216 (50.2%) in the placebo group (adjusted risk ratio 1.03, 95% confidence interval 0.91 to 1.18). Severe ovarian hyperstimulation syndrome occurred in three and six participants in the vitamin D and placebo groups, respectively (adjusted risk difference -0.7%, 95% confidence interval -2.0% to 0.6%). Although vitamin D supplementation (4000 IU/day) for up to 90 days increases serum 25-OHD levels, this does not translate to improved live birth rates after the first transfer for patients with polycystic ovary syndrome. ClinicalTrials.gov NCT04082650.

#3

Comparing ovulation induction strategies for unexplained infertility: protocol for a systematic review and network meta-analysis.

BMJ open2026 Jan 28

Unexplained infertility affects about 30% of couples seeking help for infertility, yet the optimal ovulation induction strategy remains largely unclear. Letrozole, clomiphene citrate and gonadotropins are widely used, alone or in combination, with or without intrauterine insemination (IUI), but evidence of comparative effectiveness and safety is inconsistent. Most reviews are restricted to pairwise comparisons or mixed infertility populations. This protocol describes a systematic review and network meta-analysis (NMA) to compare ovulation induction strategies specifically in unexplained infertility. Parallel-group randomised controlled trials (RCTs), including women aged 18-40 years with unexplained infertility, will be eligible. Interventions include letrozole, clomiphene citrate, gonadotropins, combination regimens and expectant management/ placebo, with or without IUI. The primary outcome will be live birth per woman randomised; if unavailable, ongoing or clinical pregnancy will be considered. Secondary outcomes include ovulation, multiple pregnancy, miscarriage, ovarian hyperstimulation syndrome, ectopic pregnancy, neonatal outcomes, time to pregnancy, adverse events and cycle cancellation rates. Databases (MEDLINE/PubMed, Embase, Cochrane Library, Scopus and Web of Science), trial registry (ClinicalTrials.gov), and grey literature (postgraduate theses, conference abstracts and dissertations) will be searched from inception to September 2025. Two reviewers will independently screen, extract data and assess risk of bias (RoB-2). Pairwise random-effects meta-analyses will precede a Bayesian and frequentist NMA (if sufficient network). If feasible, component NMA will be performed to estimate marginal effects of drug and procedural components. Certainty of evidence will be assessed using the CINeMA framework (GRADE for NMA). Publication bias will be assessed using funnel plots and Egger's test, where feasible. No ethics approval is required. Findings will be published in peer-reviewed journals, presented at conferences and made available through open-access repositories. CRD420251145492. The review was registered prospectively; the review start date is 11 September 2025 and the anticipated end date is 3 March 2026.

#4

Innovations in assisted reproductive technologies: evaluating efficacy, safety, and long-term outcomes in female infertility.

Obstetrics &amp; gynecology science2026 Jan

This narrative review evaluates innovations in assisted reproductive technology (ART) for female infertility, focusing on efficacy, safety, and long-term outcomes. The key objectives include synthesizing advancements such as artificial intelligence (AI)-driven embryo selection, preimplantation genetic testing (PGT), vitrification, and time-lapse imaging, along with their clinical applications. Evidence indicates that PGT can improve implantation and live birth rates per transfer in selected patient groups, that is, those with recurrent pregnancy loss or advanced maternal age. Evidence of AI-assisted selection is promising, but predominantly retrospective, with the potential to improve the efficiency of embryo selection, but has not yet been proven across a variety of clinical settings. However, safety concerns, including ovarian hyperstimulation syndrome, multiple pregnancies, and potential long-term maternal and offspring health risks, persist. Critical reflections highlight ethical dilemmas (e.g., "designer babies", embryo disposition), psychological stressors for patients, and disparities in ART access due to socioeconomic factors. This review underscores the need for personalized protocols, robust longitudinal studies on child development, and equitable policy frameworks. These conclusions advocate for interdisciplinary collaboration to balance technological innovation with ethical integrity, psychological support, and global accessibility.

#5

Cost-Effectiveness of Follitropin Delta Compared with Follitropins Alfa and Beta in Controlled Ovarian Stimulation for Assisted Reproductive Technologies (ART) in France.

PharmacoEconomics - open2026 Mar 11

Follitropin delta, using a personalized dosing regimen, is an effective treatment option for women undergoing controlled ovarian stimulation (COS) for in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). The aim of this study was to develop a model to determine cost effectiveness of follitropin delta compared with follitropins alfa and beta for women undergoing IVF/ICSI in France. A decision-tree model was developed comparing the outcomes of treatment with follitropin delta versus other follitropins through ongoing pregnancy (OP) and live birth (LB) rates in fresh cycles. Pooled data from the pivotal clinical trials ESTHER (EU + rest of world; NCT01956110), GRAPE (Pan-Asia; NCT03296527), and STORK (Japan; NCT03228680) was used for the economic model. The analyses were stratified by age and ovarian reserve profile and reflected a single COS cycle. Costs were estimated from the healthcare perspective in France, and uncertainty was assessed through sensitivity analyses. In women with an elevated anti-Müllerian hormone level (≥15 pmol/L), follitropin delta achieved a higher rate of LB (31.4% vs 25.8%, p = 0.01) and a numerically higher rate of OP (35.7% vs 31.6%) compared with follitropins alfa/beta. Additionally, treatment with follitropin delta was associated with numerically fewer miscarriages (4.3% vs 5.8%) and lower ovarian hyperstimulation syndrome (OHSS) incidence (8.2% vs 11.5%). Total treatment cycle cost with/without delivery cost was €5479/€4099 for follitropin delta, €5335/€4191 for follitropin alfa, and €5387/€4243 for follitropin beta. The incremental cost-effectiveness ratio was €2579/LB for follitropin delta versus follitropin alfa. Follitropin beta was shown to be less efficient, and more costly (i.e. dominated). Excluding the delivery cost, follitropin delta was more efficient and less costly (i.e. dominant) versus other follitropins. Probabilistic sensitivity analyses supported the deterministic results, showing > 76% probability of follitropin delta being dominant when assessing cost per additional OP. Similar results were observed in the overall population of women. Follitropin delta provides an effective alternative to follitropin alfa and beta with a potential cost-savings opportunity, excluding the delivery cost, due to higher OP and LB rates in the fresh cycle transfers.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC1.590 artigos no totalmostrando 197

2026

Cost-Effectiveness of Follitropin Delta Compared with Follitropins Alfa and Beta in Controlled Ovarian Stimulation for Assisted Reproductive Technologies (ART) in France.

PharmacoEconomics - open
2026

Reproductive Health After Kidney Transplantation: Insights Into Infertility and Assisted Techniques.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
2026

Corrigendum to "Prevention of moderate and severe ovarian hyperstimulation syndrome: a guideline" [Fertil Steril 2024;121:230-45].

Fertility and sterility
2026

Pre-trigger risk scoring for moderate-to-severe ovarian hyperstimulation syndrome in in vitro fertilization and intracytoplasmic sperm injection cycles.

Journal of ovarian research
2026

Views on outpatient paracentesis and GnRH antagonists for ovarian hyperstimulation syndrome: a qualitative study of patients and healthcare professionals.

Health technology assessment (Winchester, England)
2026

Association of Sleeve Gastrectomy With the Management of Ovarian Hyperstimulation Syndrome: A Retrospective Study.

Cureus
2026

Transcriptomic Profiling Reveals Urokinase-Type Plasminogen Activator-Mediated Regulation of Metabolic Competence and Cumulus Expansion During Mouse Oocyte In Vitro Maturation.

International journal of molecular sciences
2026

C-Phycocyanin ameliorates ovarian hyperstimulation syndrome by mitigating inflammation and enhances fertility in an OHSS mouse model.

Journal of ovarian research
2026

ESHRE guideline: ovarian stimulation for IVF/ICSI: an update in 2025†.

Human reproduction (Oxford, England)
2026

Flavonoids and polycystic ovary syndrome.

Food &amp; function
2025

Clinical practice guideline for female fertility preservation.

Frontiers in medicine
2026

Vitamin D supplementation before in vitro fertilisation in women with polycystic ovary syndrome: multicentre, double blind, placebo controlled, randomised clinical trial.

BMJ (Clinical research ed.)
2026

The letrozole use in reproductive medicine: Beyond aromatase inhibition - a comprehensive review.

Turkish journal of obstetrics and gynecology
2026

Unlocking new horizons in egg donation: clinical and logistical benefits of double ovarian stimulation.

F&amp;S reports
2026

Prostaglandin F2α for preventing and treating severe ovarian hyperstimulation syndrome: a targeted therapy hidden in plain sight.

Ultrasound in obstetrics &amp; gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
2026

Minimal Dose Paradigm in IUI Stimulation for Unexplained Infertility: Letrozole-Initiated Late Gonadotropin Protocol.

Journal of clinical medicine
2026

Exploratory pilot trial of astaxanthin supplementation in PCOS patients at risk of OHSS with focus on RAGE-NFκB pathway.

Scientific reports
2026

The efficacy and safety of Cangfu Daotan decoction in the treatment of infertility associated with polycystic ovary syndrome: a systematic review and meta-analysis.

Journal of ovarian research
2026

Integrated Prediction System for Individualized Ovarian Stimulation and Ovarian Hyperstimulation Syndrome Prevention: Algorithm Development and Validation.

Journal of medical Internet research
2025

A randomized controlled trial comparing combination of letrozole and clomiphene citrate or letrozole alone for ovarian stimulation in infertile women.

Journal of family medicine and primary care
2026

The importance of ovary-immune interactions in the context of age and disease.

Frontiers in neuroendocrinology
2026

Sphingosine-1-phosphate in ovarian hyperstimulation syndrome: Biomarker promise and therapeutic peril.

Turkish journal of obstetrics and gynecology
2026

Comparing ovulation induction strategies for unexplained infertility: protocol for a systematic review and network meta-analysis.

BMJ open
2026

Efficacy of Stop GnRH-Agonist/Antagonist versus GnRH-Antagonist Protocols in In Vitro Fertilization Cycles of Patients with Polycystic Ovary Syndrome: A Pilot Randomized Controlled Trial.

International journal of fertility &amp; sterility
2025

Right Middle Cerebral Artery Occlusion Following Ovarian Hyperstimulation Syndrome: A Case Study.

Cureus
2026

Comparison of in vitro fertilization outcomes between patients with and without polycystic ovary syndrome.

Medicine
2025

Multiple Pregnancy (Quintuplets) and Treatment Considerations for Critical Ovarian Hyperstimulation Syndrome.

Cureus
2026

Overcoming oral medication allergy and cervical stenosis in an anovulatory in vitro fertilization patient: a case report.

Journal of medical case reports
2026

Ovarian hyperstimulation syndrome in a premature newborn.

Anales de pediatria
2025

The Trigger in IVF Cycles: Molecular Pathways and Clinical Implications.

International journal of molecular sciences
2025

[Chinese Expert Consensus on GnRH-a in Obstetrics and Gynecology].

Zhonghua fu chan ke za zhi
2025

Effects of high basal luteinizing hormone levels on in vitro fertilization/intra-cytoplasmic injection outcomes in polycystic ovarian syndrome: a retrospective study.

Journal of ovarian research
2026

Comparative study of two ovulation induction therapies and laparoscopic ovarian drilling on clinical outcomes in women with clomiphene citrate-resistant polycystic ovary syndrome.

Clinical and experimental reproductive medicine
2026

Fertility preservation in endometriosis: current strategies and outcomes.

Minerva obstetrics and gynecology
2026

The impact of follicle-stimulating hormone receptor mutations on female ovarian function and pregnancy outcomes: a systematic review†.

Biology of reproduction
2025

Effect of oral contraceptive pretreatment on IVF outcomes in women with polycystic ovary syndrome using a long GnRH agonist protocol.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
2025

Feasibility and efficacy of random-start progestin-primed ovarian stimulation: a multicenter pilot randomized controlled trial in oocyte donation.

Reproductive biology and endocrinology : RB&amp;E
2025

Impact of assisted reproductive therapy on kidney and pregnancy outcomes in women with early-stage chronic kidney disease: a longitudinal analysis.

BMC pregnancy and childbirth
2025

Pregnancy-Related Acute Kidney Injury in Spontaneous Ovarian Hyperstimulation Syndrome: A Case Report.

Cureus
2025

Investigating the effects of melatonin on structural and vascular changes in an experimentally induced ovarian hyperstimulation syndrome model : Effects of melatonin on experimentally induced ovarian hyperstimulation syndrome.

Histochemistry and cell biology
2026

Innovations in assisted reproductive technologies: evaluating efficacy, safety, and long-term outcomes in female infertility.

Obstetrics &amp; gynecology science
2026

Real-World Effectiveness and Safety of Recombinant Human Follicle-Stimulating Hormone (rhFSH) in Infertile Women undergoing Assisted Reproductive Technology (ART): A Korean Nationwide Cohort Study.

Clinical pharmacology and therapeutics
2025

Assisted reproductive technology and reproductive, perinatal, and maternal outcomes: evidence from an umbrella review of systematic reviews with meta-analyses of randomized controlled trials.

BMC medicine
2025

Undetectable Serum Level of Anti-Müllerian Hormone (AMH) in a Woman with an Unpredictable Hyper-Response During Controlled Ovarian Stimulation for an IVF-ICSI Program: Case Report.

Diseases (Basel, Switzerland)
2025

The Effect of Retinoic Acid and Bevacizumab on Ovarian Hyperstimulation Syndrome.

Journal of clinical practice and research
2025

The Evolution of In Vitro Fertilization Practices in Saudi Arabia: Historical Perspectives and Future Directions.

Cureus
2026

Severe Ovarian Hyperstimulation Syndrome (OHSS) After Gonadotrophin Releasing Hormone Agonist (GnRHa) Triggering.

The Australian &amp; New Zealand journal of obstetrics &amp; gynaecology
2026

2,000 IU hCG is the optimal dose in a dual hCG/GnRH agonist trigger to achieve comparable pregnancy rates to hCG alone in fresh embryo transfers.

Journal of assisted reproduction and genetics
2025

Fibrinogen and cytokines as biomarkers of ovarian hyperstimulation syndrome in women undergoing assisted reproductive technology treatment: A prospective cohort study.

The Journal of international medical research
2025

Comparative study between calcium gluconate with diosmin, cabergoline, and cabergoline with diosmin in prevention of ovarian hyperstimulation syndrome in high-risk women undergoing intracytoplasmic sperm injection (ICSI) procedures.

Frontiers in pharmacology
2025

Risk factors and clinical outcomes of late-onset severe ovarian hyperstimulation syndrome in advanced maternal age women undergoing fresh embryo transfer.

Journal of ovarian research
2025

Spontaneous ovarian hyperstimulation in a nonpregnant woman with PCOS: a rare case highlighting FMN2 missense mutation and androgen receptor gene deletion.

Journal of ovarian research
2025

The Effect of Bazedoxifene and Fulvestrant for Preventing Ovarian Hyperstimulation Syndrome: An Experimental Study.

Journal of clinical medicine
2025

Real-World Safety and Effectiveness of Ganirelix for Ovarian Stimulation in Chinese Women: A Multicenter, Prospective, Single-Arm, Observational Study.

Women's health reports (New Rochelle, N.Y.)
2025

Wenyang Lishui Formula Ameliorates Symptoms of Ovarian Hyperstimulation Syndrome: A Prospective Cohort Study.

Chinese journal of integrative medicine
2026

Pelvic Puzzles: Imaging Non-Traumatic Emergencies of the Female Pelvis: A Comprehensive Review.

Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes
2025

Growth Hormone's Impact on Oxidative Stress, Ovarian Response, and In Vitro Fertilization in Polycystic Ovary Syndrome Across Different Ages.

British journal of hospital medicine (London, England : 2005)
2025

Clinical Outcomes of High-Dose Follitropin Delta in POSEIDON (Patient-Oriented Strategies Encompassing Individualized Oocyte Number) Group 4: An Exploratory Case Series on Follicular Efficiency and Embryo Development.

Cureus
2025

Association of Follicular Distribution Patterns in Polycystic Ovaries with Clinical Outcomes in Assisted Reproductive Technology Cycles: A Prospective Cohort Study.

International journal of fertility &amp; sterility
2025

Natural conception complicated by spontaneous ovarian hyperstimulation syndrome in the setting of severe primary hypothyroidism: A case series.

Medicine
2026

Characterization of the secretory profile of gonadotroph pituitary tumors.

Journal of endocrinological investigation
2025

Advances in human oocyte in vitro maturation: current status and future perspectives: a narrative review.

Reproduction &amp; fertility
2025

Oocyte maturation triggers in high-responders: a report on 1,217 consecutive cycles.

Reproduction &amp; fertility
2025

Prevention of ovarian hyperstimulation syndrome: optimizing habitual stimulation strategies.

F&amp;S reports
2025

Impact of gonadotropin selection on risk of ovarian hyperstimulation syndrome in predicted high responders: a Menopur in Gonadotropin-releasing hormone Antagonist Single Embryo Transfer-High Responder trial analysis.

F&amp;S reports
2025

Time to pregnancy in young women with high response to controlled ovarian stimulation undergoing fresh transfer vs. a freeze-all strategy after in vitro fertilization treatment-a nationwide register-based cohort study.

F&amp;S reports
2025

Histological, Immunohistochemical, and Biochemical Evaluation of the Effect of Berberine on Ovarian Hyperstimulation Syndrome in Rats.

The journal of obstetrics and gynaecology research
2025

Comparison of efficacy, safety, and economy of recombinant and urinary follicle-stimulating hormone in women with a predicted normal response undergoing assisted reproductive technology.

Journal of ovarian research
2025

Letrozole at the Crossroads of Efficacy and Fetal Safety in Ovulation Induction: A Narrative Review.

Biomedicines
2025

Synchronised approach for intrauterine insemination in subfertile couples.

The Cochrane database of systematic reviews
2025

Effectiveness and safety of follitropin delta in routine clinical practice in the Nordics and Switzerland (the NORSOS study): a prospective non-interventional study.

Frontiers in endocrinology
2026

Dual trigger vs. gonadotropin-releasing hormone agonist trigger for elective fertility preservation: a randomized controlled trial.

Fertility and sterility
2025

Ovarian hyperstimulation revealing a functional gonadotroph adenoma: a case report.

The Pan African medical journal
2025

Advanced high-grade serous carcinoma of the ovary after IVF treatment in a 38-year-old nulligravida: A case report of diagnostic challenges in the presence of OHSS.

Taiwanese journal of obstetrics &amp; gynecology
2025

Expression of concern 'Calcium infusion for the prevention of ovarian hyperstimulation syndrome: a double-blind randomized controlled trial' [Fertil Steril 2015; 103:101-5].

Fertility and sterility
2025

Correlation Between Fertility Stress, Psychological Capital, and Conjugal Communication Patterns in Hospitalized Patients with Ovarian Hyperstimulation Syndrome During in vitro Fertilization-Embryo Transfer Cycles.

International journal of women's health
2025

Clinical outcomes from assisted reproductive technology in predicted hyper-responders: a narrative review.

Minerva obstetrics and gynecology
2025

Severe, prolonged primary hypothyroidism causing ovarian hyperstimulation: an adult presentation (Van Wyk-Grumbach syndrome).

BMJ case reports
2025

Combination of Continuous Use of Oral Clomiphene Citrate with Injectable Gonadotropins for Ovarian Stimulation: A Single-Center Study.

Life (Basel, Switzerland)
2025

Comparison of clinical outcomes between flexible antagonist protocol and long luteal phase protocol in patients with normal ovarian reserve function: a prospective cohort study.

Frontiers in endocrinology
2025

Is the risk of ovarian hyperstimulation syndrome adequately addressed in high anti-Müllerian hormone and PCOS patients undergoing IVF?

Reproductive biomedicine online
2025

The influence of serum luteinising hormone concentrations post GnRH agonist trigger on metaphase II oocytes in IVF/ICSI cycles.

European journal of obstetrics, gynecology, and reproductive biology
2025

Electroacupuncture Improves Pregnancy Outcomes of Assisted Reproduction and Mitochondrial Function of Granulosa Cells in Patients with Polycystic Ovary Syndrome of Phlegm-Dampness Syndrome.

Chinese journal of integrative medicine
2025

Comparing the Outcomes of In-Vitro Fertilization in Same-Sex Female Couples Using Their Partner's Egg Versus Their Own Egg: A Systematic Review.

Journal of homosexuality
2025

Risk prediction models for ovarian hyperstimulation syndrome: a systematic review and meta-analysis.

BMC pregnancy and childbirth
2025

Spontaneous Ovarian Hyperstimulation Syndrome and Hyperprolactinemia due to Primary Hypothyroidism: An Adolescent Case Report.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
2025

Ovarian stimulation protocols in fresh cycles and in elective freeze-all cycles.

Systems biology in reproductive medicine
2025

A comparison of the effects of progestin-primed ovarian stimulation protocol and gonadotropin-releasing hormone antagonist protocol in assisted reproductive technology: a systematic review and meta-analysis.

Journal of assisted reproduction and genetics
2025

Severe Early-onset Ovarian Hyperstimulation Syndrome with Isolated Pleural Effusion following Agonist Trigger in Gonadotropin-releasing Hormone Antagonist Cycle: A Case Report.

Journal of human reproductive sciences
2025

In Vitro Fertilization in Africa: Mild Versus Conventional Antagonist Ovarian Stimulation Protocols in Expected Normal Responders Undergoing IVF/ICSI: A Cohort Study From Ethiopia.

Public health challenges
2025

The Double-Edged Nature of the Gonadotropin-Releasing Hormone Agonist (GnRHa) Long Protocol: A Case of Paradoxical Ovarian Hyperstimulation During the Expected Downregulation Phase.

Journal of clinical medicine
2026

Ovarian stimulation with follitropin delta is safe and effective: results from the RITA randomized, double-blind, placebo-controlled trials.

Fertility and sterility
2025

Impact of Elevated Oestrogen Levels on hCG Trigger Day on Clinical Pregnancy Outcome and OHSS Incidence in Long-Acting GnRHa Down-Regulated IVF/ICSI-ET Cycles.

International journal of women's health
2025

Successful delivery in a patient with ovarian hyperstimulation syndrome complicated by deep vein thrombosis: A case report.

Medicine
2025

The roles of MAPK signaling pathway in ovarian folliculogenesis.

Journal of ovarian research
2025

Analysis of couple communication patterns as a mediator of fertility-related stress and psychological capital in women with severe ovarian hyperstimulation syndrome after embryo transfer.

Scientific reports
2025

Curcumin alleviates ovarian hyperstimulation syndrome in the rat model via inhibiting the nuclear factor kappa B/hypoxia-inducible factor-1α signaling pathway.

Histochemistry and cell biology
2025

Gonadotropin Releasing Hormone-Antagonist Protocol (GnRH-ant) Combined Letrozole (LE) for Expected High Ovarian Responders (HOR): a Cohort Study.

Reproductive sciences (Thousand Oaks, Calif.)
2025

Ovarian stimulation with follitropin delta for in vitro fertilization: a multicentre, randomized, assessor-blind comparison with follitropin alfa using conventional dosing regimens (ADAPT-1 trial).

Human reproduction (Oxford, England)
2025

Bilateral atypical ovarian masses: don't overlook a functional gonadotropic pituitary adenoma.

Frontiers in endocrinology
2025

Controlled ovarian stimulation protocols for assisted reproduction: a network meta-analysis.

The Cochrane database of systematic reviews
2025

Effect of GnRH antagonist pretreatment before controlled ovarian stimulation in antagonist protocol for infertile women with PCOS undergoing IVF/ICSI: A propensity score matching analysis.

Medicine
2025

Corrigendum to "A rare presentation of isolated right-sided pleural effusion in the context of ovarian hyperstimulation syndrome: A case report" [Case Reports in Women's Health 32 (2021) e00347].

Case reports in women's health
2025

Acute Kidney Injury in Endocrine Emergencies.

Kidney &amp; blood pressure research
2025

Effect of Nifedipine in Preventing Ovarian Hyperstimulation Syndrome through TRPC1 Ion Channel Inhibition.

Reproductive sciences (Thousand Oaks, Calif.)
2025

Association between ovarian hyperstimulation syndrome and adverse obstetric and neonatal outcomes in Korea: a nationwide health insurance database study.

Journal of assisted reproduction and genetics
2025

Optimizing Oocyte Quality in Polycystic Ovary Syndrome (PCOS): The Impact of Neurotrophin-4 in In Vitro Maturation Protocols.

Journal of pharmacy &amp; bioallied sciences
2025

The impact of hCG trigger versus dual trigger on reproductive outcomes in elderly infertile women: a retrospective cohort study.

Frontiers in endocrinology
2025

Association of long-term PM2.5 and its components exposure with ovarian hyperstimulation syndrome risk in assisted reproductive technology patients.

Environmental pollution (Barking, Essex : 1987)
2025

Undetected pregnancies in luteal phase stimulation - could they prevent ovarian hyperstimulation syndrome becoming a complication of the past?

Reproductive biomedicine online
2025

A genetically engineered mouse model for ovarian hyperstimulation syndrome.

PeerJ
2025

Comparative study of cabergoline and hydroxychloroquine to prevent ovarian hyperstimulation syndrome (OHSS) in PCOS patients: a pilot randomized clinical trial.

Journal of ovarian research
2025

Spontaneous Ovarian Hyperstimulation Syndrome in Natural Conception: A Case Report.

Cureus
2025

Potential therapeutic targets for ovarian hyperstimulation syndrome revealed by proteome-wide mendelian randomization and colocalization analysis.

Journal of reproductive immunology
2025

Visualization analysis of ovarian hyperstimulation syndrome based on bibliometrics.

Medicine
2025

Analysis of emotional fluctuations in infertile women during ART treatment: the impact of ovarian hyperstimulation.

Journal of psychosomatic obstetrics and gynaecology
2025

The Therapeutic Potential of EGCG and Pro-EGCG in Mitigating Ovarian Hyperstimulation Syndrome: Unraveling the Modulatory Mechanism through the VEGF Pathway.

International journal of biological sciences
2026

DNA methylation landscapes of in vitro matured oocytes retrieved during endoscopic gynaecological procedures.

Journal of genetics and genomics = Yi chuan xue bao
2025

Impact of ovarian hyperstimulation syndrome on intracytoplasmic sperm injection outcomes in poly-cystic ovarian syndrome women: A cross-sectional study.

International journal of reproductive biomedicine
2025

Just the facts: ovarian hyperstimulation syndrome - a primer for emergency physicians.

CJEM
2025

Imaging in Acute Obstetric Conditions: A Pictorial Essay.

Korean journal of radiology
2025

Spontaneous ovarian hyperstimulation syndrome mimicking ovarian cancer in a nonpregnant woman: A case report and literature review.

The Journal of international medical research
2025

GnRH ability to release FSH and LH in women with functional hypothalamic amenorrhea: a retrospective cohort study about women with and without polycystic ovarian morphology.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
2025

Ovarian hyperstimulation syndrome - a complication of the past.

Reproductive biomedicine online
2025

Renewing ovarian stimulation.

Reproductive biomedicine online
2025

Post-marketing safety profile of ganirelix in women: a 20-year pharmacovigilance analysis of global adverse drug event databases (2004-2024).

BMC pharmacology &amp; toxicology
2025

Ovarian hyperstimulation syndrome in a patient on tamoxifen therapy.

BMJ case reports
2025

Impact of different endometrial preparation protocols on pregnancy outcomes in patients at high risk for ovarian hyperstimulation syndrome: a propensity score matched retrospective cohort study.

BMC pregnancy and childbirth
2025

Mendelian randomization study reveals causal associations between plasma metabolites, immune cell phenotypes, and ovarian hyperstimulation syndrome.

Journal of reproductive immunology
2025

Development and externally validated prediction model of individualization of FSH starting dose in the depot GnRH agonist protocol for the early follicular phase.

Frontiers in endocrinology
2025

Is There An Association between Dyslipidemia and The Risk of Ovarian Hyperstimulation Syndrome in A Population of Non-Obese Polycystic Ovary Syndrome Patients? A Cross-Sectional Study.

International journal of fertility &amp; sterility
2025

Randomized controlled trial to evaluate the impact of follicle priming on IVM outcomes in women with polycystic ovaries: CFA versus FSH-B.

Human reproduction (Oxford, England)
2025

Gonadotropins for ovulation induction in women with polycystic ovary syndrome.

The Cochrane database of systematic reviews
2025

Ambient temperature and ovarian hyperstimulation syndrome: An observational study.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
2025

Minimising OHSS in women with PCOS.

Frontiers in endocrinology
2025

Pharmacogenetic analysis using artificial intelligence (AI) to identify polymorphisms associated with sub-optimal ovarian response and hyper-response.

Journal of assisted reproduction and genetics
2025

Effect of different combinations of serum antimüllerian hormone levels and body mass index on pregnancy outcomes in women with polycystic ovary syndrome.

AJOG global reports
2025

Lower serum level of hypoxia-inducible factor 1alpha during controlled ovarian stimulation is related to the higher risk of developing ovarian hyperstimulation syndrome.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
2025

Efficacy and safety of simplified follitropin delta dosing in women undergoing intrauterine insemination in Indonesia.

African journal of reproductive health
2025

The treatment of adenomyosis-induced ovarian hyperstimulation syndrome with leuprolide.

Minerva medica
2025

Ovarian Hyperstimulation Syndrome Following In-Vitro Fertilization: A Case Report.

Cureus
2025

Cabergoline Use and Pregnancy Outcomes: A Systematic Review.

Birth defects research
2025

The application value of ultrasound in ovarian hyperstimulation syndrome and literature review.

The British journal of radiology
2025

Nomogram model to predict the risk of moderate to severe ovarian hyperstimulation syndrome of long protocol group in fresh cycle.

Scientific reports
2025

Unusual ovarian hyperstimulation syndrome presentation: Pleural effusion without ascites. A case report.

World journal of clinical cases
2025

A retrospective study "myo-inositol is a cost-saving strategy for controlled ovarian stimulation in non-polycystic ovary syndrome art patients.".

Health economics review
2025

High-dose estrogen impairs demethylation of H3K27me3 by decreasing Kdm6b expression during ovarian hyperstimulation in mice.

Journal of Zhejiang University. Science. B
2025

Freeze-all indications in women with subfertility undergoing IVF: a cohort study.

Reproductive biomedicine online
2025

Ovarian Hyperstimulation secondary to clomiphene citrate resulting in ovarian torsion: A rare report.

International journal of surgery case reports
2025

Bilateral massive bloody pleural effusions as a rare presentation of ovarian hyperstimulation syndrome: A case report and literature review.

Taiwanese journal of obstetrics &amp; gynecology
2025

Trends in fertility preservation treatments in Japan until 2023: analysis of the Japan Oncofertility Registry.

International journal of clinical oncology
2025

Fertility stimulation protocols in women with cancer.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
2025

Benign obstetric and gynaecological diseases associated with pleural effusion: a narrative review.

Breathe (Sheffield, England)
2025

Risk of Thrombosis in Women Undergoing In Vitro Fertilization: A Narrative Review.

Journal of clinical medicine
2025

Effects of 100 IU versus 150 IU hCG supplementation on oocyte and embryo quality in patients aged ≥ 35 years: a propensity score-matched analysis.

International journal of medical sciences
2025

[New treatment strategies in assisted reproduction].

Ugeskrift for laeger
2024

The Role of GnRH Agonist Therapy and Hysterosalpingography (HSG) in Diagnosing and Treating Tubal Factor Infertility.

Journal of pharmacy &amp; bioallied sciences
2025

In vitro maturation in subfertile women with polycystic ovarian syndrome undergoing assisted reproduction.

The Cochrane database of systematic reviews
2024

Follicular fluid meiosis activating sterol supplementation enhances oocyte maturation and fertilization in a microfluidic system: A lab trial study.

International journal of reproductive biomedicine
2025

Update on the therapeutic role of metformin in the management of polycystic ovary syndrome: Effects on pathophysiologic process and fertility outcomes.

Women's health (London, England)
2024

Cost-Effectiveness and Clinical Outcomes of Controlled Ovarian Stimulation With Follitropin Delta and Follitropin Alfa: A Retrospective Study.

Cureus
2025

Triggering final follicular maturation for IVF cycles.

Reproductive biology and endocrinology : RB&amp;E
2025

Controlled ovarian hyperstimulation with or without letrozole for fertility preservation in breast cancer patients: study protocol for a randomised controlled trial.

BMJ open
2025

Oocyte donors' physical outcomes and psychosocial experiences: a mixed-methods study.

Fertility and sterility
2025

Gonadotropin-releasing hormone agonist protocols for pituitary suppression in assisted reproduction.

The Cochrane database of systematic reviews
2025

Oocyte yield and live birth rate after follitropin delta dosing and fresh embryo transfer: an individual patient data meta-analysis.

Reproductive biomedicine online
2025

Biosimilars versus the originator of follitropin alfa for ovarian stimulation in ART: a systematic review and meta-analysis.

Human reproduction (Oxford, England)
2024

A FSH-secreting pituitary adenoma discovered after ovarian hyperstimulation syndrome: a case report, illustrating pitfalls in the interpretation of serum FSH levels.

BMC women's health
2025

Development and validation of a gonadotropin dose selection model for optimized ovarian stimulation in IVF/ICSI: an individual participant data meta-analysis.

Human reproduction update
2024

Comparative efficacy and safety of metformin, anti-obesity agents, and myoinositol in improving IVF/ICSI outcomes and reducing ovarian hyperstimulation syndrome in women with polycystic ovary syndrome: a systematic review and network meta-analysis.

Journal of ovarian research
2025

Prevention of ovarian hyperstimulation syndrome (OHSS): British Fertility Society policy and practice guideline.

Human fertility (Cambridge, England)
2025

Progesterone Primed Ovarian Stimulation (PPOS) vs. clomiphene Primed Ovarian Stimulation (CPOS) in high responder (HR) patients undergoing controlled ovarian stimulation. A Randomised Control trial.

JBRA assisted reproduction
2024

Safety and effectiveness of dual trigger (GnRH agonist + HCG) versus HCG alone in patients with high ovarian response.

American journal of translational research
2024

Efficacy of Local N-Acetylcysteine Administration in Mitigating OHSS Parameters: A Comparative Analysis With Dopaminergic Agonist in the OHSS Model.

International journal of endocrinology
2024

Fractalkine/CX3CL1 and macrophage inflammatory protein- 1β/CCL4 activity in the rat ovary with induced ovarian hyperstimulation.

Turkish journal of obstetrics and gynecology
2024

Reduction of Ovarian Cysts After Endoscopic Surgery for Follicle-Stimulating Hormone-Producing Pituitary Adenoma.

JCEM case reports
2024

Ovarian Hyperstimulation and Maternal Virilisation with Successful Pregnancy Outcome: A case report.

Sultan Qaboos University medical journal
2025

Recurrent spontaneous ovarian hyperstimulation in a young nonpregnant Chinese woman with Rathke cleft cyst and a KISS1R variant: A rare case report and literature review.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
2024

Efficacy of acupuncture for pregnancy with early-onset ovarian hyperstimulation syndrome: study protocol for a randomised controlled clinical trial.

BMJ open
2024

Role of In Vitro Fertilization (IVF) in Unexplained Infertility Management: A Systematic Review.

Cureus
2024

mTOR inhibitors as potential therapeutics for endometriosis: a narrative review.

Molecular human reproduction
2025

Triggering oocyte maturation in in vitro fertilization treatment in healthy responders: a systematic review and network meta-analysis.

Fertility and sterility
2025

Identification and Characterization of Novel FSHR Copy Number Variations Causing Premature Ovarian Insufficiency.

American journal of medical genetics. Part A
2024

Fixed versus flexible gonadotropin releasing hormone antagonist protocol in women with polycystic ovary syndrome undergoing in vitro fertilization: An RCT.

International journal of reproductive biomedicine
2024

A simple and practical approach to elective egg freezing to control costs and expand access to care.

Journal of ovarian research
2024

A repeated gonadotropin-releasing hormone agonist trigger improves pregnancy outcomes of frozen-thawed embryo transfer in GnRH antagonist cycles: a retrospective propensity-matched score analysis.

Journal of assisted reproduction and genetics
2025

The role of letrozole in in vitro fertilization treatment: new remedy or old mirage?

Fertility and sterility
2024

Case 330: Ovarian Torsion in the Setting of Ovarian Hyperstimulation Syndrome.

Radiology
2024

Estradiol-to-follicle ratio on human chorionic gonadotropin day is a novel predictor of gestational diabetes mellitus in women receiving fresh embryo transfer.

Frontiers in endocrinology
2025

Lupus activity and pregnancy outcomes in systemic lupus erythematosus patients undergoing assisted reproductive therapy: A systematic review and meta-analysis.

Clinical rheumatology
2024

Recent developments in drug treatment strategies for infertility in patients with polycystic ovary syndrome.

Expert opinion on pharmacotherapy
2025

In vitro maturation of oocytes: what is already known?†.

Biology of reproduction
2024

Relationship between CCL25/CCR9 Levels in Follicular Fluid and High Ovarian Response in Patients with Polycystic Ovary Syndrome.

International journal of endocrinology
2024

The good, the bad and the ugly of luteal phase stimulations.

Reproductive biomedicine online
2024

[Fertility preservation in patients with hematopoietic diseases].

[Rinsho ketsueki] The Japanese journal of clinical hematology
2024

The clinical diversity of primary hypothyroidism presenting as a spontaneous ovarian hyperstimulation syndrome.

Endocrinology, diabetes &amp; metabolism case reports
2024

Ovarian Hyperstimulation Syndrome (OHSS): A Narrative Review and Legal Implications.

Journal of personalized medicine
Ver todos os 1.590 no EuropePMC

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Transcriptomic Profiling Reveals Urokinase-Type Plasminogen Activator-Mediated Regulation of Metabolic Competence and Cumulus Expansion During Mouse Oocyte In Vitro Maturation.
    International journal of molecular sciences· 2026· PMID 41751918mais citado
  2. Vitamin D supplementation before in vitro fertilisation in women with polycystic ovary syndrome: multicentre, double blind, placebo controlled, randomised clinical trial.
    BMJ (Clinical research ed.)· 2026· PMID 41702641mais citado
  3. Comparing ovulation induction strategies for unexplained infertility: protocol for a systematic review and network meta-analysis.
    BMJ open· 2026· PMID 41605576mais citado
  4. Innovations in assisted reproductive technologies: evaluating efficacy, safety, and long-term outcomes in female infertility.
    Obstetrics &amp; gynecology science· 2026· PMID 41330358mais citado
  5. Cost-Effectiveness of Follitropin Delta Compared with Follitropins Alfa and Beta in Controlled Ovarian Stimulation for Assisted Reproductive Technologies (ART) in France.
    PharmacoEconomics - open· 2026· PMID 41811581mais citado
  6. Atypical presentation of severe ovarian hyperstimulation syndrome complicated by isolated pleural effusions: a case series and literature review.
    Hum Fertil (Camb)· 2026· PMID 41995024recente
  7. Effects of human umbilical cord derived mesenchymal stem cells transplantation on ovarian function in rats with ovarian hyperstimulation syndrome.
    J Mol Histol· 2026· PMID 41989604recente
  8. Comparing Ovulation Outcomes of Letrozole-Tamoxifen-Estradiolwith and without Vitamin E in Infertile Women with PolycysticOvary Syndrome: A Double-Blind, Randomized Clinical Trial.
    Int J Fertil Steril· 2026· PMID 41983358recente
  9. The Management of Ovarian Hyperstimulation Syndrome Green-Top Guideline No. 5.
    BJOG· 2026· PMID 41975565recente
  10. Impact of Assisted Reproductive Technologies in Women with Cardiovascular Disease.
    Can J Cardiol· 2026· PMID 41962840recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:64739(Orphanet)
  2. OMIM OMIM:608115(OMIM)
  3. MONDO:0011972(MONDO)
  4. GARD:16668(GARD (NIH))
  5. Variantes catalogadas(ClinVar)
  6. Busca completa no PubMed(PubMed)
  7. Artigo Wikipedia(Wikipedia)
  8. Q1760461(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Síndrome hiperestimulação ovariana
Compêndio · Raras BR

Síndrome hiperestimulação ovariana

ORPHA:64739 · MONDO:0011972
Prevalência
Unknown
Herança
Not applicable
CID-10
N98.1 · Hiperestimulação dos ovários
CID-11
Ensaios
1 ativos
Medicamentos
12 registrados
Início
Adolescent, Adult
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0085083
EuropePMC
Wikidata
Wikipedia
Papers 10a
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