Uma complicação da indução da ovulação no tratamento da infertilidade. É classificado pela gravidade dos sintomas que incluem aumento dos ovários, múltiplos folículos ovarianos; cistos ovarianos; ascite; e edema generalizado. A síndrome completa pode causar insuficiência renal, dificuldade respiratória e até morte. O aumento da permeabilidade capilar é causado pelas substâncias vasoativas, como os fatores de crescimento endotelial vascular, secretados pelos ovários excessivamente estimulados.
Introdução
O que você precisa saber de cara
Uma complicação da indução da ovulação no tratamento da infertilidade. É classificado pela gravidade dos sintomas que incluem aumento dos ovários, múltiplos folículos ovarianos; cistos ovarianos; ascite; e edema generalizado. A síndrome completa pode causar insuficiência renal, dificuldade respiratória e até morte. O aumento da permeabilidade capilar é causado pelas substâncias vasoativas, como os fatores de crescimento endotelial vascular, secretados pelos ovários excessivamente estimulados.
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Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 10 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 19 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
1 gene identificado com associação a esta condição. Padrão de herança: Not applicable.
G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (PubMed:24058690)
Cell membrane
Ovarian dysgenesis 1
An autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, poorly developed streak ovaries, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Medicamentos e terapias
Mecanismo: Progesterone receptor agonist
Mecanismo: Gonadotropin-releasing hormone receptor antagonist
Mecanismo: Gonadotropin-releasing hormone receptor agonist
Mecanismo: Luteinizing hormone/Choriogonadotropin receptor agonist
Mecanismo: Dopamine D2 receptor agonist
Mecanismo: Cytochrome P450 19A1 inhibitor
Mecanismo: Glucocorticoid receptor agonist
Mecanismo: Dopamine D2 receptor agonist
Mecanismo: D2-like dopamine receptor agonist
Mecanismo: Cysteinyl leukotriene receptor 1 antagonist
Variantes genéticas (ClinVar)
66 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 61 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
2 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Síndrome hiperestimulação ovariana
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
🟢 Recrutando agora
1 pesquisa recrutando participantes. Converse com seu médico sobre a possibilidade de participar.
Outros ensaios clínicos
75 ensaios clínicos encontrados, 1 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 1.459
Transcriptomic Profiling Reveals Urokinase-Type Plasminogen Activator-Mediated Regulation of Metabolic Competence and Cumulus Expansion During Mouse Oocyte In Vitro Maturation.
In vitro maturation (IVM) of mammalian oocytes is an essential fertility option for patients at risk of ovarian hyperstimulation syndrome or needing urgent fertility preservation. However, poor outcomes indicate a limited understanding of the molecular mechanisms behind cumulus cell expansion and extracellular matrix (ECM) remodeling. This study investigated the role of serum-derived urokinase-type plasminogen activator (PLAU) in mouse oocyte IVM. Immature cumulus-oocyte complexes from CD-1 mice were cultured with or without serum, and PLAU activity was blocked using 4-chlorophenylguanidine hydrochloride. Cumulus expansion, oocyte maturation, and cumulus cell transcriptomes were analyzed. Serum supplementation enhanced cumulus expansion and maturation, while absence of serum or PLAU inhibition hindered both processes. External PLAU partially rescued these issues under serum-free conditions. Transcriptome analysis demonstrated that inhibiting PLAU activity reduces the expression of ovulation- and metabolism-related genes, such as those involved in glycolysis and carbohydrate metabolism, while increasing genes related to vesicle-mediated transport. PLAU is crucial for cumulus expansion and metabolic regulation during IVM, affecting ECM remodeling and oocyte quality. Supporting IVM culture media with proteolytic and metabolic factors could improve outcomes in assisted reproduction.
Vitamin D supplementation before in vitro fertilisation in women with polycystic ovary syndrome: multicentre, double blind, placebo controlled, randomised clinical trial.
To evaluate whether vitamin D supplementation improves live birth rates in women with polycystic ovary syndrome undergoing in vitro fertilisation. Multicentre, double blind, placebo controlled, randomised clinical trial. 24 fertility centres in China. 876 participants with polycystic ovary syndrome undergoing in vitro fertilisation. Participants were randomised (1:1) to receive vitamin D 4000 IU/day or placebo before in vitro fertilisation for up to 90 days until the trigger day. The primary outcome was live birth after the first embryo transfer. Secondary outcomes included serum 25-hydroxyvitamin D (25-OHD) levels on trigger day, pregnancy outcomes, fertility outcomes, and adverse events including severe ovarian hyperstimulation syndrome. Of 876 participants randomised, 865 were included in the modified intention-to-treat analysis, with 435 in the vitamin D group and 430 in the placebo group. Baseline mean serum 25-OHD levels were 16.5±7.2 and 16.1±6.7 ng/mL in the vitamin D and placebo groups, respectively. On the day of triggering, the serum 25-OHD level was significantly higher in the vitamin D group than in the placebo group (32.3±11.2 v 18.2±7.6 ng/mL, adjusted mean difference 13.6, 95% confidence interval 10.9 to 16.3). 226 (52.0%) live births occurred in the vitamin D group and 216 (50.2%) in the placebo group (adjusted risk ratio 1.03, 95% confidence interval 0.91 to 1.18). Severe ovarian hyperstimulation syndrome occurred in three and six participants in the vitamin D and placebo groups, respectively (adjusted risk difference -0.7%, 95% confidence interval -2.0% to 0.6%). Although vitamin D supplementation (4000 IU/day) for up to 90 days increases serum 25-OHD levels, this does not translate to improved live birth rates after the first transfer for patients with polycystic ovary syndrome. ClinicalTrials.gov NCT04082650.
Comparing ovulation induction strategies for unexplained infertility: protocol for a systematic review and network meta-analysis.
Unexplained infertility affects about 30% of couples seeking help for infertility, yet the optimal ovulation induction strategy remains largely unclear. Letrozole, clomiphene citrate and gonadotropins are widely used, alone or in combination, with or without intrauterine insemination (IUI), but evidence of comparative effectiveness and safety is inconsistent. Most reviews are restricted to pairwise comparisons or mixed infertility populations. This protocol describes a systematic review and network meta-analysis (NMA) to compare ovulation induction strategies specifically in unexplained infertility. Parallel-group randomised controlled trials (RCTs), including women aged 18-40 years with unexplained infertility, will be eligible. Interventions include letrozole, clomiphene citrate, gonadotropins, combination regimens and expectant management/ placebo, with or without IUI. The primary outcome will be live birth per woman randomised; if unavailable, ongoing or clinical pregnancy will be considered. Secondary outcomes include ovulation, multiple pregnancy, miscarriage, ovarian hyperstimulation syndrome, ectopic pregnancy, neonatal outcomes, time to pregnancy, adverse events and cycle cancellation rates. Databases (MEDLINE/PubMed, Embase, Cochrane Library, Scopus and Web of Science), trial registry (ClinicalTrials.gov), and grey literature (postgraduate theses, conference abstracts and dissertations) will be searched from inception to September 2025. Two reviewers will independently screen, extract data and assess risk of bias (RoB-2). Pairwise random-effects meta-analyses will precede a Bayesian and frequentist NMA (if sufficient network). If feasible, component NMA will be performed to estimate marginal effects of drug and procedural components. Certainty of evidence will be assessed using the CINeMA framework (GRADE for NMA). Publication bias will be assessed using funnel plots and Egger's test, where feasible. No ethics approval is required. Findings will be published in peer-reviewed journals, presented at conferences and made available through open-access repositories. CRD420251145492. The review was registered prospectively; the review start date is 11 September 2025 and the anticipated end date is 3 March 2026.
Innovations in assisted reproductive technologies: evaluating efficacy, safety, and long-term outcomes in female infertility.
This narrative review evaluates innovations in assisted reproductive technology (ART) for female infertility, focusing on efficacy, safety, and long-term outcomes. The key objectives include synthesizing advancements such as artificial intelligence (AI)-driven embryo selection, preimplantation genetic testing (PGT), vitrification, and time-lapse imaging, along with their clinical applications. Evidence indicates that PGT can improve implantation and live birth rates per transfer in selected patient groups, that is, those with recurrent pregnancy loss or advanced maternal age. Evidence of AI-assisted selection is promising, but predominantly retrospective, with the potential to improve the efficiency of embryo selection, but has not yet been proven across a variety of clinical settings. However, safety concerns, including ovarian hyperstimulation syndrome, multiple pregnancies, and potential long-term maternal and offspring health risks, persist. Critical reflections highlight ethical dilemmas (e.g., "designer babies", embryo disposition), psychological stressors for patients, and disparities in ART access due to socioeconomic factors. This review underscores the need for personalized protocols, robust longitudinal studies on child development, and equitable policy frameworks. These conclusions advocate for interdisciplinary collaboration to balance technological innovation with ethical integrity, psychological support, and global accessibility.
Cost-Effectiveness of Follitropin Delta Compared with Follitropins Alfa and Beta in Controlled Ovarian Stimulation for Assisted Reproductive Technologies (ART) in France.
Follitropin delta, using a personalized dosing regimen, is an effective treatment option for women undergoing controlled ovarian stimulation (COS) for in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). The aim of this study was to develop a model to determine cost effectiveness of follitropin delta compared with follitropins alfa and beta for women undergoing IVF/ICSI in France. A decision-tree model was developed comparing the outcomes of treatment with follitropin delta versus other follitropins through ongoing pregnancy (OP) and live birth (LB) rates in fresh cycles. Pooled data from the pivotal clinical trials ESTHER (EU + rest of world; NCT01956110), GRAPE (Pan-Asia; NCT03296527), and STORK (Japan; NCT03228680) was used for the economic model. The analyses were stratified by age and ovarian reserve profile and reflected a single COS cycle. Costs were estimated from the healthcare perspective in France, and uncertainty was assessed through sensitivity analyses. In women with an elevated anti-Müllerian hormone level (≥15 pmol/L), follitropin delta achieved a higher rate of LB (31.4% vs 25.8%, p = 0.01) and a numerically higher rate of OP (35.7% vs 31.6%) compared with follitropins alfa/beta. Additionally, treatment with follitropin delta was associated with numerically fewer miscarriages (4.3% vs 5.8%) and lower ovarian hyperstimulation syndrome (OHSS) incidence (8.2% vs 11.5%). Total treatment cycle cost with/without delivery cost was €5479/€4099 for follitropin delta, €5335/€4191 for follitropin alfa, and €5387/€4243 for follitropin beta. The incremental cost-effectiveness ratio was €2579/LB for follitropin delta versus follitropin alfa. Follitropin beta was shown to be less efficient, and more costly (i.e. dominated). Excluding the delivery cost, follitropin delta was more efficient and less costly (i.e. dominant) versus other follitropins. Probabilistic sensitivity analyses supported the deterministic results, showing > 76% probability of follitropin delta being dominant when assessing cost per additional OP. Similar results were observed in the overall population of women. Follitropin delta provides an effective alternative to follitropin alfa and beta with a potential cost-savings opportunity, excluding the delivery cost, due to higher OP and LB rates in the fresh cycle transfers.
Publicações recentes
Atypical presentation of severe ovarian hyperstimulation syndrome complicated by isolated pleural effusions: a case series and literature review.
Effects of human umbilical cord derived mesenchymal stem cells transplantation on ovarian function in rats with ovarian hyperstimulation syndrome.
Comparing Ovulation Outcomes of Letrozole-Tamoxifen-Estradiolwith and without Vitamin E in Infertile Women with PolycysticOvary Syndrome: A Double-Blind, Randomized Clinical Trial.
The Management of Ovarian Hyperstimulation Syndrome Green-Top Guideline No. 5.
Impact of Assisted Reproductive Technologies in Women with Cardiovascular Disease.
📚 EuropePMC1.590 artigos no totalmostrando 197
Cost-Effectiveness of Follitropin Delta Compared with Follitropins Alfa and Beta in Controlled Ovarian Stimulation for Assisted Reproductive Technologies (ART) in France.
PharmacoEconomics - openReproductive Health After Kidney Transplantation: Insights Into Infertility and Assisted Techniques.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ TransplantationCorrigendum to "Prevention of moderate and severe ovarian hyperstimulation syndrome: a guideline" [Fertil Steril 2024;121:230-45].
Fertility and sterilityPre-trigger risk scoring for moderate-to-severe ovarian hyperstimulation syndrome in in vitro fertilization and intracytoplasmic sperm injection cycles.
Journal of ovarian researchViews on outpatient paracentesis and GnRH antagonists for ovarian hyperstimulation syndrome: a qualitative study of patients and healthcare professionals.
Health technology assessment (Winchester, England)Association of Sleeve Gastrectomy With the Management of Ovarian Hyperstimulation Syndrome: A Retrospective Study.
CureusTranscriptomic Profiling Reveals Urokinase-Type Plasminogen Activator-Mediated Regulation of Metabolic Competence and Cumulus Expansion During Mouse Oocyte In Vitro Maturation.
International journal of molecular sciencesC-Phycocyanin ameliorates ovarian hyperstimulation syndrome by mitigating inflammation and enhances fertility in an OHSS mouse model.
Journal of ovarian researchESHRE guideline: ovarian stimulation for IVF/ICSI: an update in 2025†.
Human reproduction (Oxford, England)Flavonoids and polycystic ovary syndrome.
Food & functionClinical practice guideline for female fertility preservation.
Frontiers in medicineVitamin D supplementation before in vitro fertilisation in women with polycystic ovary syndrome: multicentre, double blind, placebo controlled, randomised clinical trial.
BMJ (Clinical research ed.)The letrozole use in reproductive medicine: Beyond aromatase inhibition - a comprehensive review.
Turkish journal of obstetrics and gynecologyUnlocking new horizons in egg donation: clinical and logistical benefits of double ovarian stimulation.
F&S reportsProstaglandin F2α for preventing and treating severe ovarian hyperstimulation syndrome: a targeted therapy hidden in plain sight.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and GynecologyMinimal Dose Paradigm in IUI Stimulation for Unexplained Infertility: Letrozole-Initiated Late Gonadotropin Protocol.
Journal of clinical medicineExploratory pilot trial of astaxanthin supplementation in PCOS patients at risk of OHSS with focus on RAGE-NFκB pathway.
Scientific reportsThe efficacy and safety of Cangfu Daotan decoction in the treatment of infertility associated with polycystic ovary syndrome: a systematic review and meta-analysis.
Journal of ovarian researchIntegrated Prediction System for Individualized Ovarian Stimulation and Ovarian Hyperstimulation Syndrome Prevention: Algorithm Development and Validation.
Journal of medical Internet researchA randomized controlled trial comparing combination of letrozole and clomiphene citrate or letrozole alone for ovarian stimulation in infertile women.
Journal of family medicine and primary careThe importance of ovary-immune interactions in the context of age and disease.
Frontiers in neuroendocrinologySphingosine-1-phosphate in ovarian hyperstimulation syndrome: Biomarker promise and therapeutic peril.
Turkish journal of obstetrics and gynecologyComparing ovulation induction strategies for unexplained infertility: protocol for a systematic review and network meta-analysis.
BMJ openEfficacy of Stop GnRH-Agonist/Antagonist versus GnRH-Antagonist Protocols in In Vitro Fertilization Cycles of Patients with Polycystic Ovary Syndrome: A Pilot Randomized Controlled Trial.
International journal of fertility & sterilityRight Middle Cerebral Artery Occlusion Following Ovarian Hyperstimulation Syndrome: A Case Study.
CureusComparison of in vitro fertilization outcomes between patients with and without polycystic ovary syndrome.
MedicineMultiple Pregnancy (Quintuplets) and Treatment Considerations for Critical Ovarian Hyperstimulation Syndrome.
CureusOvercoming oral medication allergy and cervical stenosis in an anovulatory in vitro fertilization patient: a case report.
Journal of medical case reportsOvarian hyperstimulation syndrome in a premature newborn.
Anales de pediatriaThe Trigger in IVF Cycles: Molecular Pathways and Clinical Implications.
International journal of molecular sciences[Chinese Expert Consensus on GnRH-a in Obstetrics and Gynecology].
Zhonghua fu chan ke za zhiEffects of high basal luteinizing hormone levels on in vitro fertilization/intra-cytoplasmic injection outcomes in polycystic ovarian syndrome: a retrospective study.
Journal of ovarian researchComparative study of two ovulation induction therapies and laparoscopic ovarian drilling on clinical outcomes in women with clomiphene citrate-resistant polycystic ovary syndrome.
Clinical and experimental reproductive medicineFertility preservation in endometriosis: current strategies and outcomes.
Minerva obstetrics and gynecologyThe impact of follicle-stimulating hormone receptor mutations on female ovarian function and pregnancy outcomes: a systematic review†.
Biology of reproductionEffect of oral contraceptive pretreatment on IVF outcomes in women with polycystic ovary syndrome using a long GnRH agonist protocol.
Gynecological endocrinology : the official journal of the International Society of Gynecological EndocrinologyFeasibility and efficacy of random-start progestin-primed ovarian stimulation: a multicenter pilot randomized controlled trial in oocyte donation.
Reproductive biology and endocrinology : RB&EImpact of assisted reproductive therapy on kidney and pregnancy outcomes in women with early-stage chronic kidney disease: a longitudinal analysis.
BMC pregnancy and childbirthPregnancy-Related Acute Kidney Injury in Spontaneous Ovarian Hyperstimulation Syndrome: A Case Report.
CureusInvestigating the effects of melatonin on structural and vascular changes in an experimentally induced ovarian hyperstimulation syndrome model : Effects of melatonin on experimentally induced ovarian hyperstimulation syndrome.
Histochemistry and cell biologyInnovations in assisted reproductive technologies: evaluating efficacy, safety, and long-term outcomes in female infertility.
Obstetrics & gynecology scienceReal-World Effectiveness and Safety of Recombinant Human Follicle-Stimulating Hormone (rhFSH) in Infertile Women undergoing Assisted Reproductive Technology (ART): A Korean Nationwide Cohort Study.
Clinical pharmacology and therapeuticsAssisted reproductive technology and reproductive, perinatal, and maternal outcomes: evidence from an umbrella review of systematic reviews with meta-analyses of randomized controlled trials.
BMC medicineUndetectable Serum Level of Anti-Müllerian Hormone (AMH) in a Woman with an Unpredictable Hyper-Response During Controlled Ovarian Stimulation for an IVF-ICSI Program: Case Report.
Diseases (Basel, Switzerland)The Effect of Retinoic Acid and Bevacizumab on Ovarian Hyperstimulation Syndrome.
Journal of clinical practice and researchThe Evolution of In Vitro Fertilization Practices in Saudi Arabia: Historical Perspectives and Future Directions.
CureusSevere Ovarian Hyperstimulation Syndrome (OHSS) After Gonadotrophin Releasing Hormone Agonist (GnRHa) Triggering.
The Australian & New Zealand journal of obstetrics & gynaecology2,000 IU hCG is the optimal dose in a dual hCG/GnRH agonist trigger to achieve comparable pregnancy rates to hCG alone in fresh embryo transfers.
Journal of assisted reproduction and geneticsFibrinogen and cytokines as biomarkers of ovarian hyperstimulation syndrome in women undergoing assisted reproductive technology treatment: A prospective cohort study.
The Journal of international medical researchComparative study between calcium gluconate with diosmin, cabergoline, and cabergoline with diosmin in prevention of ovarian hyperstimulation syndrome in high-risk women undergoing intracytoplasmic sperm injection (ICSI) procedures.
Frontiers in pharmacologyRisk factors and clinical outcomes of late-onset severe ovarian hyperstimulation syndrome in advanced maternal age women undergoing fresh embryo transfer.
Journal of ovarian researchSpontaneous ovarian hyperstimulation in a nonpregnant woman with PCOS: a rare case highlighting FMN2 missense mutation and androgen receptor gene deletion.
Journal of ovarian researchThe Effect of Bazedoxifene and Fulvestrant for Preventing Ovarian Hyperstimulation Syndrome: An Experimental Study.
Journal of clinical medicineReal-World Safety and Effectiveness of Ganirelix for Ovarian Stimulation in Chinese Women: A Multicenter, Prospective, Single-Arm, Observational Study.
Women's health reports (New Rochelle, N.Y.)Wenyang Lishui Formula Ameliorates Symptoms of Ovarian Hyperstimulation Syndrome: A Prospective Cohort Study.
Chinese journal of integrative medicinePelvic Puzzles: Imaging Non-Traumatic Emergencies of the Female Pelvis: A Comprehensive Review.
Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistesGrowth Hormone's Impact on Oxidative Stress, Ovarian Response, and In Vitro Fertilization in Polycystic Ovary Syndrome Across Different Ages.
British journal of hospital medicine (London, England : 2005)Clinical Outcomes of High-Dose Follitropin Delta in POSEIDON (Patient-Oriented Strategies Encompassing Individualized Oocyte Number) Group 4: An Exploratory Case Series on Follicular Efficiency and Embryo Development.
CureusAssociation of Follicular Distribution Patterns in Polycystic Ovaries with Clinical Outcomes in Assisted Reproductive Technology Cycles: A Prospective Cohort Study.
International journal of fertility & sterilityNatural conception complicated by spontaneous ovarian hyperstimulation syndrome in the setting of severe primary hypothyroidism: A case series.
MedicineCharacterization of the secretory profile of gonadotroph pituitary tumors.
Journal of endocrinological investigationAdvances in human oocyte in vitro maturation: current status and future perspectives: a narrative review.
Reproduction & fertilityOocyte maturation triggers in high-responders: a report on 1,217 consecutive cycles.
Reproduction & fertilityPrevention of ovarian hyperstimulation syndrome: optimizing habitual stimulation strategies.
F&S reportsImpact of gonadotropin selection on risk of ovarian hyperstimulation syndrome in predicted high responders: a Menopur in Gonadotropin-releasing hormone Antagonist Single Embryo Transfer-High Responder trial analysis.
F&S reportsTime to pregnancy in young women with high response to controlled ovarian stimulation undergoing fresh transfer vs. a freeze-all strategy after in vitro fertilization treatment-a nationwide register-based cohort study.
F&S reportsHistological, Immunohistochemical, and Biochemical Evaluation of the Effect of Berberine on Ovarian Hyperstimulation Syndrome in Rats.
The journal of obstetrics and gynaecology researchComparison of efficacy, safety, and economy of recombinant and urinary follicle-stimulating hormone in women with a predicted normal response undergoing assisted reproductive technology.
Journal of ovarian researchLetrozole at the Crossroads of Efficacy and Fetal Safety in Ovulation Induction: A Narrative Review.
BiomedicinesSynchronised approach for intrauterine insemination in subfertile couples.
The Cochrane database of systematic reviewsEffectiveness and safety of follitropin delta in routine clinical practice in the Nordics and Switzerland (the NORSOS study): a prospective non-interventional study.
Frontiers in endocrinologyDual trigger vs. gonadotropin-releasing hormone agonist trigger for elective fertility preservation: a randomized controlled trial.
Fertility and sterilityOvarian hyperstimulation revealing a functional gonadotroph adenoma: a case report.
The Pan African medical journalAdvanced high-grade serous carcinoma of the ovary after IVF treatment in a 38-year-old nulligravida: A case report of diagnostic challenges in the presence of OHSS.
Taiwanese journal of obstetrics & gynecologyExpression of concern 'Calcium infusion for the prevention of ovarian hyperstimulation syndrome: a double-blind randomized controlled trial' [Fertil Steril 2015; 103:101-5].
Fertility and sterilityCorrelation Between Fertility Stress, Psychological Capital, and Conjugal Communication Patterns in Hospitalized Patients with Ovarian Hyperstimulation Syndrome During in vitro Fertilization-Embryo Transfer Cycles.
International journal of women's healthClinical outcomes from assisted reproductive technology in predicted hyper-responders: a narrative review.
Minerva obstetrics and gynecologySevere, prolonged primary hypothyroidism causing ovarian hyperstimulation: an adult presentation (Van Wyk-Grumbach syndrome).
BMJ case reportsCombination of Continuous Use of Oral Clomiphene Citrate with Injectable Gonadotropins for Ovarian Stimulation: A Single-Center Study.
Life (Basel, Switzerland)Comparison of clinical outcomes between flexible antagonist protocol and long luteal phase protocol in patients with normal ovarian reserve function: a prospective cohort study.
Frontiers in endocrinologyIs the risk of ovarian hyperstimulation syndrome adequately addressed in high anti-Müllerian hormone and PCOS patients undergoing IVF?
Reproductive biomedicine onlineThe influence of serum luteinising hormone concentrations post GnRH agonist trigger on metaphase II oocytes in IVF/ICSI cycles.
European journal of obstetrics, gynecology, and reproductive biologyElectroacupuncture Improves Pregnancy Outcomes of Assisted Reproduction and Mitochondrial Function of Granulosa Cells in Patients with Polycystic Ovary Syndrome of Phlegm-Dampness Syndrome.
Chinese journal of integrative medicineComparing the Outcomes of In-Vitro Fertilization in Same-Sex Female Couples Using Their Partner's Egg Versus Their Own Egg: A Systematic Review.
Journal of homosexualityRisk prediction models for ovarian hyperstimulation syndrome: a systematic review and meta-analysis.
BMC pregnancy and childbirthSpontaneous Ovarian Hyperstimulation Syndrome and Hyperprolactinemia due to Primary Hypothyroidism: An Adolescent Case Report.
Archives de pediatrie : organe officiel de la Societe francaise de pediatrieOvarian stimulation protocols in fresh cycles and in elective freeze-all cycles.
Systems biology in reproductive medicineA comparison of the effects of progestin-primed ovarian stimulation protocol and gonadotropin-releasing hormone antagonist protocol in assisted reproductive technology: a systematic review and meta-analysis.
Journal of assisted reproduction and geneticsSevere Early-onset Ovarian Hyperstimulation Syndrome with Isolated Pleural Effusion following Agonist Trigger in Gonadotropin-releasing Hormone Antagonist Cycle: A Case Report.
Journal of human reproductive sciencesIn Vitro Fertilization in Africa: Mild Versus Conventional Antagonist Ovarian Stimulation Protocols in Expected Normal Responders Undergoing IVF/ICSI: A Cohort Study From Ethiopia.
Public health challengesThe Double-Edged Nature of the Gonadotropin-Releasing Hormone Agonist (GnRHa) Long Protocol: A Case of Paradoxical Ovarian Hyperstimulation During the Expected Downregulation Phase.
Journal of clinical medicineOvarian stimulation with follitropin delta is safe and effective: results from the RITA randomized, double-blind, placebo-controlled trials.
Fertility and sterilityImpact of Elevated Oestrogen Levels on hCG Trigger Day on Clinical Pregnancy Outcome and OHSS Incidence in Long-Acting GnRHa Down-Regulated IVF/ICSI-ET Cycles.
International journal of women's healthSuccessful delivery in a patient with ovarian hyperstimulation syndrome complicated by deep vein thrombosis: A case report.
MedicineThe roles of MAPK signaling pathway in ovarian folliculogenesis.
Journal of ovarian researchAnalysis of couple communication patterns as a mediator of fertility-related stress and psychological capital in women with severe ovarian hyperstimulation syndrome after embryo transfer.
Scientific reportsCurcumin alleviates ovarian hyperstimulation syndrome in the rat model via inhibiting the nuclear factor kappa B/hypoxia-inducible factor-1α signaling pathway.
Histochemistry and cell biologyGonadotropin Releasing Hormone-Antagonist Protocol (GnRH-ant) Combined Letrozole (LE) for Expected High Ovarian Responders (HOR): a Cohort Study.
Reproductive sciences (Thousand Oaks, Calif.)Ovarian stimulation with follitropin delta for in vitro fertilization: a multicentre, randomized, assessor-blind comparison with follitropin alfa using conventional dosing regimens (ADAPT-1 trial).
Human reproduction (Oxford, England)Bilateral atypical ovarian masses: don't overlook a functional gonadotropic pituitary adenoma.
Frontiers in endocrinologyControlled ovarian stimulation protocols for assisted reproduction: a network meta-analysis.
The Cochrane database of systematic reviewsEffect of GnRH antagonist pretreatment before controlled ovarian stimulation in antagonist protocol for infertile women with PCOS undergoing IVF/ICSI: A propensity score matching analysis.
MedicineCorrigendum to "A rare presentation of isolated right-sided pleural effusion in the context of ovarian hyperstimulation syndrome: A case report" [Case Reports in Women's Health 32 (2021) e00347].
Case reports in women's healthAcute Kidney Injury in Endocrine Emergencies.
Kidney & blood pressure researchEffect of Nifedipine in Preventing Ovarian Hyperstimulation Syndrome through TRPC1 Ion Channel Inhibition.
Reproductive sciences (Thousand Oaks, Calif.)Association between ovarian hyperstimulation syndrome and adverse obstetric and neonatal outcomes in Korea: a nationwide health insurance database study.
Journal of assisted reproduction and geneticsOptimizing Oocyte Quality in Polycystic Ovary Syndrome (PCOS): The Impact of Neurotrophin-4 in In Vitro Maturation Protocols.
Journal of pharmacy & bioallied sciencesThe impact of hCG trigger versus dual trigger on reproductive outcomes in elderly infertile women: a retrospective cohort study.
Frontiers in endocrinologyAssociation of long-term PM2.5 and its components exposure with ovarian hyperstimulation syndrome risk in assisted reproductive technology patients.
Environmental pollution (Barking, Essex : 1987)Undetected pregnancies in luteal phase stimulation - could they prevent ovarian hyperstimulation syndrome becoming a complication of the past?
Reproductive biomedicine onlineA genetically engineered mouse model for ovarian hyperstimulation syndrome.
PeerJComparative study of cabergoline and hydroxychloroquine to prevent ovarian hyperstimulation syndrome (OHSS) in PCOS patients: a pilot randomized clinical trial.
Journal of ovarian researchSpontaneous Ovarian Hyperstimulation Syndrome in Natural Conception: A Case Report.
CureusPotential therapeutic targets for ovarian hyperstimulation syndrome revealed by proteome-wide mendelian randomization and colocalization analysis.
Journal of reproductive immunologyVisualization analysis of ovarian hyperstimulation syndrome based on bibliometrics.
MedicineAnalysis of emotional fluctuations in infertile women during ART treatment: the impact of ovarian hyperstimulation.
Journal of psychosomatic obstetrics and gynaecologyThe Therapeutic Potential of EGCG and Pro-EGCG in Mitigating Ovarian Hyperstimulation Syndrome: Unraveling the Modulatory Mechanism through the VEGF Pathway.
International journal of biological sciencesDNA methylation landscapes of in vitro matured oocytes retrieved during endoscopic gynaecological procedures.
Journal of genetics and genomics = Yi chuan xue baoImpact of ovarian hyperstimulation syndrome on intracytoplasmic sperm injection outcomes in poly-cystic ovarian syndrome women: A cross-sectional study.
International journal of reproductive biomedicineJust the facts: ovarian hyperstimulation syndrome - a primer for emergency physicians.
CJEMImaging in Acute Obstetric Conditions: A Pictorial Essay.
Korean journal of radiologySpontaneous ovarian hyperstimulation syndrome mimicking ovarian cancer in a nonpregnant woman: A case report and literature review.
The Journal of international medical researchGnRH ability to release FSH and LH in women with functional hypothalamic amenorrhea: a retrospective cohort study about women with and without polycystic ovarian morphology.
Gynecological endocrinology : the official journal of the International Society of Gynecological EndocrinologyOvarian hyperstimulation syndrome - a complication of the past.
Reproductive biomedicine onlineRenewing ovarian stimulation.
Reproductive biomedicine onlinePost-marketing safety profile of ganirelix in women: a 20-year pharmacovigilance analysis of global adverse drug event databases (2004-2024).
BMC pharmacology & toxicologyOvarian hyperstimulation syndrome in a patient on tamoxifen therapy.
BMJ case reportsImpact of different endometrial preparation protocols on pregnancy outcomes in patients at high risk for ovarian hyperstimulation syndrome: a propensity score matched retrospective cohort study.
BMC pregnancy and childbirthMendelian randomization study reveals causal associations between plasma metabolites, immune cell phenotypes, and ovarian hyperstimulation syndrome.
Journal of reproductive immunologyDevelopment and externally validated prediction model of individualization of FSH starting dose in the depot GnRH agonist protocol for the early follicular phase.
Frontiers in endocrinologyIs There An Association between Dyslipidemia and The Risk of Ovarian Hyperstimulation Syndrome in A Population of Non-Obese Polycystic Ovary Syndrome Patients? A Cross-Sectional Study.
International journal of fertility & sterilityRandomized controlled trial to evaluate the impact of follicle priming on IVM outcomes in women with polycystic ovaries: CFA versus FSH-B.
Human reproduction (Oxford, England)Gonadotropins for ovulation induction in women with polycystic ovary syndrome.
The Cochrane database of systematic reviewsAmbient temperature and ovarian hyperstimulation syndrome: An observational study.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and ObstetricsMinimising OHSS in women with PCOS.
Frontiers in endocrinologyPharmacogenetic analysis using artificial intelligence (AI) to identify polymorphisms associated with sub-optimal ovarian response and hyper-response.
Journal of assisted reproduction and geneticsEffect of different combinations of serum antimüllerian hormone levels and body mass index on pregnancy outcomes in women with polycystic ovary syndrome.
AJOG global reportsLower serum level of hypoxia-inducible factor 1alpha during controlled ovarian stimulation is related to the higher risk of developing ovarian hyperstimulation syndrome.
Journal of physiology and pharmacology : an official journal of the Polish Physiological SocietyEfficacy and safety of simplified follitropin delta dosing in women undergoing intrauterine insemination in Indonesia.
African journal of reproductive healthThe treatment of adenomyosis-induced ovarian hyperstimulation syndrome with leuprolide.
Minerva medicaOvarian Hyperstimulation Syndrome Following In-Vitro Fertilization: A Case Report.
CureusCabergoline Use and Pregnancy Outcomes: A Systematic Review.
Birth defects researchThe application value of ultrasound in ovarian hyperstimulation syndrome and literature review.
The British journal of radiologyNomogram model to predict the risk of moderate to severe ovarian hyperstimulation syndrome of long protocol group in fresh cycle.
Scientific reportsUnusual ovarian hyperstimulation syndrome presentation: Pleural effusion without ascites. A case report.
World journal of clinical casesA retrospective study "myo-inositol is a cost-saving strategy for controlled ovarian stimulation in non-polycystic ovary syndrome art patients.".
Health economics reviewHigh-dose estrogen impairs demethylation of H3K27me3 by decreasing Kdm6b expression during ovarian hyperstimulation in mice.
Journal of Zhejiang University. Science. BFreeze-all indications in women with subfertility undergoing IVF: a cohort study.
Reproductive biomedicine onlineOvarian Hyperstimulation secondary to clomiphene citrate resulting in ovarian torsion: A rare report.
International journal of surgery case reportsBilateral massive bloody pleural effusions as a rare presentation of ovarian hyperstimulation syndrome: A case report and literature review.
Taiwanese journal of obstetrics & gynecologyTrends in fertility preservation treatments in Japan until 2023: analysis of the Japan Oncofertility Registry.
International journal of clinical oncologyFertility stimulation protocols in women with cancer.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and ObstetricsBenign obstetric and gynaecological diseases associated with pleural effusion: a narrative review.
Breathe (Sheffield, England)Risk of Thrombosis in Women Undergoing In Vitro Fertilization: A Narrative Review.
Journal of clinical medicineEffects of 100 IU versus 150 IU hCG supplementation on oocyte and embryo quality in patients aged ≥ 35 years: a propensity score-matched analysis.
International journal of medical sciences[New treatment strategies in assisted reproduction].
Ugeskrift for laegerThe Role of GnRH Agonist Therapy and Hysterosalpingography (HSG) in Diagnosing and Treating Tubal Factor Infertility.
Journal of pharmacy & bioallied sciencesIn vitro maturation in subfertile women with polycystic ovarian syndrome undergoing assisted reproduction.
The Cochrane database of systematic reviewsFollicular fluid meiosis activating sterol supplementation enhances oocyte maturation and fertilization in a microfluidic system: A lab trial study.
International journal of reproductive biomedicineUpdate on the therapeutic role of metformin in the management of polycystic ovary syndrome: Effects on pathophysiologic process and fertility outcomes.
Women's health (London, England)Cost-Effectiveness and Clinical Outcomes of Controlled Ovarian Stimulation With Follitropin Delta and Follitropin Alfa: A Retrospective Study.
CureusTriggering final follicular maturation for IVF cycles.
Reproductive biology and endocrinology : RB&EControlled ovarian hyperstimulation with or without letrozole for fertility preservation in breast cancer patients: study protocol for a randomised controlled trial.
BMJ openOocyte donors' physical outcomes and psychosocial experiences: a mixed-methods study.
Fertility and sterilityGonadotropin-releasing hormone agonist protocols for pituitary suppression in assisted reproduction.
The Cochrane database of systematic reviewsOocyte yield and live birth rate after follitropin delta dosing and fresh embryo transfer: an individual patient data meta-analysis.
Reproductive biomedicine onlineBiosimilars versus the originator of follitropin alfa for ovarian stimulation in ART: a systematic review and meta-analysis.
Human reproduction (Oxford, England)A FSH-secreting pituitary adenoma discovered after ovarian hyperstimulation syndrome: a case report, illustrating pitfalls in the interpretation of serum FSH levels.
BMC women's healthDevelopment and validation of a gonadotropin dose selection model for optimized ovarian stimulation in IVF/ICSI: an individual participant data meta-analysis.
Human reproduction updateComparative efficacy and safety of metformin, anti-obesity agents, and myoinositol in improving IVF/ICSI outcomes and reducing ovarian hyperstimulation syndrome in women with polycystic ovary syndrome: a systematic review and network meta-analysis.
Journal of ovarian researchPrevention of ovarian hyperstimulation syndrome (OHSS): British Fertility Society policy and practice guideline.
Human fertility (Cambridge, England)Progesterone Primed Ovarian Stimulation (PPOS) vs. clomiphene Primed Ovarian Stimulation (CPOS) in high responder (HR) patients undergoing controlled ovarian stimulation. A Randomised Control trial.
JBRA assisted reproductionSafety and effectiveness of dual trigger (GnRH agonist + HCG) versus HCG alone in patients with high ovarian response.
American journal of translational researchEfficacy of Local N-Acetylcysteine Administration in Mitigating OHSS Parameters: A Comparative Analysis With Dopaminergic Agonist in the OHSS Model.
International journal of endocrinologyFractalkine/CX3CL1 and macrophage inflammatory protein- 1β/CCL4 activity in the rat ovary with induced ovarian hyperstimulation.
Turkish journal of obstetrics and gynecologyReduction of Ovarian Cysts After Endoscopic Surgery for Follicle-Stimulating Hormone-Producing Pituitary Adenoma.
JCEM case reportsOvarian Hyperstimulation and Maternal Virilisation with Successful Pregnancy Outcome: A case report.
Sultan Qaboos University medical journalRecurrent spontaneous ovarian hyperstimulation in a young nonpregnant Chinese woman with Rathke cleft cyst and a KISS1R variant: A rare case report and literature review.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and ObstetricsEfficacy of acupuncture for pregnancy with early-onset ovarian hyperstimulation syndrome: study protocol for a randomised controlled clinical trial.
BMJ openRole of In Vitro Fertilization (IVF) in Unexplained Infertility Management: A Systematic Review.
CureusmTOR inhibitors as potential therapeutics for endometriosis: a narrative review.
Molecular human reproductionTriggering oocyte maturation in in vitro fertilization treatment in healthy responders: a systematic review and network meta-analysis.
Fertility and sterilityIdentification and Characterization of Novel FSHR Copy Number Variations Causing Premature Ovarian Insufficiency.
American journal of medical genetics. Part AFixed versus flexible gonadotropin releasing hormone antagonist protocol in women with polycystic ovary syndrome undergoing in vitro fertilization: An RCT.
International journal of reproductive biomedicineA simple and practical approach to elective egg freezing to control costs and expand access to care.
Journal of ovarian researchA repeated gonadotropin-releasing hormone agonist trigger improves pregnancy outcomes of frozen-thawed embryo transfer in GnRH antagonist cycles: a retrospective propensity-matched score analysis.
Journal of assisted reproduction and geneticsThe role of letrozole in in vitro fertilization treatment: new remedy or old mirage?
Fertility and sterilityCase 330: Ovarian Torsion in the Setting of Ovarian Hyperstimulation Syndrome.
RadiologyEstradiol-to-follicle ratio on human chorionic gonadotropin day is a novel predictor of gestational diabetes mellitus in women receiving fresh embryo transfer.
Frontiers in endocrinologyLupus activity and pregnancy outcomes in systemic lupus erythematosus patients undergoing assisted reproductive therapy: A systematic review and meta-analysis.
Clinical rheumatologyRecent developments in drug treatment strategies for infertility in patients with polycystic ovary syndrome.
Expert opinion on pharmacotherapyIn vitro maturation of oocytes: what is already known?†.
Biology of reproductionRelationship between CCL25/CCR9 Levels in Follicular Fluid and High Ovarian Response in Patients with Polycystic Ovary Syndrome.
International journal of endocrinologyThe good, the bad and the ugly of luteal phase stimulations.
Reproductive biomedicine online[Fertility preservation in patients with hematopoietic diseases].
[Rinsho ketsueki] The Japanese journal of clinical hematologyThe clinical diversity of primary hypothyroidism presenting as a spontaneous ovarian hyperstimulation syndrome.
Endocrinology, diabetes & metabolism case reportsOvarian Hyperstimulation Syndrome (OHSS): A Narrative Review and Legal Implications.
Journal of personalized medicineAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Transcriptomic Profiling Reveals Urokinase-Type Plasminogen Activator-Mediated Regulation of Metabolic Competence and Cumulus Expansion During Mouse Oocyte In Vitro Maturation.
- Vitamin D supplementation before in vitro fertilisation in women with polycystic ovary syndrome: multicentre, double blind, placebo controlled, randomised clinical trial.
- Comparing ovulation induction strategies for unexplained infertility: protocol for a systematic review and network meta-analysis.
- Innovations in assisted reproductive technologies: evaluating efficacy, safety, and long-term outcomes in female infertility.
- Cost-Effectiveness of Follitropin Delta Compared with Follitropins Alfa and Beta in Controlled Ovarian Stimulation for Assisted Reproductive Technologies (ART) in France.
- Atypical presentation of severe ovarian hyperstimulation syndrome complicated by isolated pleural effusions: a case series and literature review.
- Effects of human umbilical cord derived mesenchymal stem cells transplantation on ovarian function in rats with ovarian hyperstimulation syndrome.
- Comparing Ovulation Outcomes of Letrozole-Tamoxifen-Estradiolwith and without Vitamin E in Infertile Women with PolycysticOvary Syndrome: A Double-Blind, Randomized Clinical Trial.
- The Management of Ovarian Hyperstimulation Syndrome Green-Top Guideline No. 5.
- Impact of Assisted Reproductive Technologies in Women with Cardiovascular Disease.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:64739(Orphanet)
- OMIM OMIM:608115(OMIM)
- MONDO:0011972(MONDO)
- GARD:16668(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q1760461(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
