Arenarine D Promotes Pancreatic β Cell Proliferation Via DYRK1A Inhibition for T1DM Therapy.

Seed metabolomic profiling of contrasting mung bean (Vigna radiata) genotypes under heat stress.

Cerebrospinal fluid and plasma metabolites in Parkinson's disease: a Mendelian randomization study.

Tyrosine Hydroxylase Deficiency Impairs TH Axonal Transport, Brain Function, and Neuronal Plasticity.

Perturbation of azurophilic granule integrity drives NLRP3-independent IL-1β processing and release in neutrophils.

Peptide-Based ROR1-Targeting PET Ligands for Melanoma Tumor Imaging: Design and Preclinical Evaluation.

Oseltamivir aziridines are potent influenza neuraminidase inhibitors and imaging agents.

In silico designing of palbociclib loaded PLGA long-acting intramuscular injection for palliative therapy of HR+/HER2- metastatic breast cancer.

Blocking SHP2 benefits FGFR2 inhibitor and overcomes its resistance in FGFR2-amplified gastric cancer.

Development of a C5-Azidoacetamide-Modified 4-Amino-2,3-Difluorosialic Acid Activity-Based Probe for Labeling of Influenza A Neuraminidases.

Lipid-Engineered Small-Sized Metal-Organic Frameworks for Targeted Delivery of Anlotinib in Lung Cancer Treatment.

Exploring SIK2-CXCL5 interactions in neutrophils: A novel mechanism for modulating IL-23 and psoriasis progression.

Risk of CNS relapse following pathological complete response to neoadjuvant chemotherapy in early breast cancer.

Changes of intracellular and extracellular organic matter in Microcystis colonies after ultrasonic stress and during recovery cultivation.

The ammonia transporter gene family and its immune regulatory role in the Pacific oyster (Crassostrea gigas).

Micro-nanoplastics induce the physiological toxicity and metabolic disorder of Bacillus cereus DFH-1.

Lactylation Converts ABHD6 into a Mitochondrial Regulator that Drives Lenvatinib Resistance in Hepatocellular Carcinoma.

Klebsiella Enrichment Is Associated with Disease Severity in Ulcerative Colitis.

Dual Inhibition of COX-2/5-LOX Through Novel Hybrids of NSAIDs and Peptides: Insights from Molecular Dynamics Simulation and Per-Residue Decomposition.

Molecular mechanism of silver nanoparticles inhibiting primary root growth of Oryza sativa L.

AXL and c-Met Dual-Targeting in Non-Small Cell Lung Cancer: A Review of Small-Molecule Inhibitors and Their Structure-Activity Relationships.

Python metabolomics uncovers a conserved postprandial metabolite and gut-brain feeding pathway.

Tyrosine hydroxylase as a therapeutic target: insights from adrenergic nerve and TNBC cell interactions.

Innovative Nanocarriers of Sorafenib in the Optimisation of Therapeutic Outcome: Challenges and Applications in Breast Cancer.

Microglia cause HIV-induced transcriptional and metabolic changes in human neural organoids.

Overcoming vascular niche-mediated TKI resistance in acute myeloid leukemia through miR-126 inhibition.

Molecular and cellular consequences of tumour-autonomous IL-6 signalling in intrahepatic cholangiocarcinoma.

Deubiquitination-driven adaptive programs in hepatocellular carcinoma: The emerging role of USP22 in hypoxia, metabolic rewiring, and drug resistance.

A CHKA-PML autophagy checkpoint enables tumors to evade glutamine starvation.

Influence of Peptide-Based Chelator Sequences on HER2-Targeting Radiopeptide.

A Biologically Informed Machine Learning Pipeline Uncovers Metabolic Features of Intestinal Barrier Dysfunction.

Enhanced Whitening Effect of the Formulations via Inhibition of Tyrosinase Activity by Combination of 4-n-Butylresorcinol, Licochalcone A and Glabridin at an Optimal Ratio.

Uncontrolled hypertension in siblings: an unsuspected diagnosis.

Outcomes of CDK4/6 Inhibitor-Based Therapy in Premenopausal HR+/HER2- Metastatic Breast Cancer: Real World Data From A Multicenter Study.

Orthogonal quorum sensing circuits enable dynamic regulation in Escherichia coli.

FBXO3-mediated DUSP9 ubiquitination promotes leukemia stem cell maintenance and tyrosine kinase inhibitor resistance in chronic myeloid leukemia.

Antagonistic potential of Trichoderma koningiopsis and its effect on plant defense response.

Lactate Metabolism-Immune Regulation-Related Gene Signature in Lower-Grade Gliomas: Prognostic Model Development and Immune Characterization.

A Chirality-Guided Molecular Recognition Strategy for Targeting Intrinsically Disordered Proteins.

A PTPN23-dependent ESCRT pathway is essential for constitutive secretion in mammalian cells.

Targeted Ferroptosis Improves RPE Phagocytosis via MERTK/NFE2L2/HMOX1 Axis to Alleviate Retinitis Pigmentosa.

Skin Melanin Content and the Foveal Avascular Zone Correlation in a Healthy White Population.

The critical role of Atpif1 in Her2-targeted CAR-T cell therapy for solid tumor via modulation of metabolism and mtDNA-STING signal pathway.

Tribolium castaneum with longer duration of tonic immobility have more variations corresponding to the human Parkinson's disease genomic region.

USP20 governs tyrosine kinase inhibitors resistance through ferroptosis evasion by targeting GPX4 in cancers.

Canonical and Non-Canonical Mechanisms of Insulin-Dependent Signaling Regulating Adipogenic Differentiation in Adipose Tissue Renewal.

Inhibition of MAFB and PI3K/AKT Signaling for Hereditary FSGS with Multicentric Carpotarsal Osteolysis.

Simultaneous inhibition of mTOR and STING as an approach to reduce alpha-synuclein and lysosphingolipid levels in peripheral blood monocytederived macrophages and the SH-SY5Y cell line: implications for therapy of Parkinson's disease.

What's next in psoriatic arthritis therapy? A look at the pipeline.

Mistranslation from an endogenous tRNA variant in human pan-genome cell lines.

Polymer-Surfactant Stabilized Amorphous Nanosuspension of Pazopanib: Box-Behnken Optimization and In-vivo Evaluation.

Multi-omic analysis of the liver-breast axis reveals key hepatic mediators of breast cancer progression.

Impact of NPAS2 on mPFC dopamine synthesis and nap behavior.

[Effect of ZHU Lian's acupuncture stimulation method on neurological function in rats with ischemic stroke based on the miR-34a-5p/YWHAG pathway].

[Effects of electroacupuncture on the SIRT3/NF-κB /MAPK signaling pathway in the substantia nigra of mice with Parkinson's disease].

[Wheat-grain moxibustion improves sleep in perimenopausal insomnia rats by regulating the SIRT1/Nrf2 signaling pathway].

Pyrotinib or placebo in combination with trastuzumab and docetaxel for HER2 positive metastatic breast cancer: long term survival results from randomised phase 3 PHILA trial.

Pharmaco-behavioral profiling identifies suppressors of autism gene-associated phenotypes in zebrafish.

A Density Functional Theory Study on Trimethylamine N-Oxide Interactions with Amino Acid Side Chain Models: Probing the Driving Force of Lysozyme Aggregation.

Befotertinib restored chemosensitivity to multidrug-resistant cancer cells by inhibiting the drug efflux activity of ABCB1.

Progression from Stage 1 to Stage 3 Type 1 Diabetes Characterized by Hypoglycemia.

DNA Aptamer-Functionalized Fluorescent Silica Nanoparticles: A Robust Strategy for Specific Detection and Bioimaging of HER2-Overexpressing Breast Cancer.

Untargeted serum metabolomics and air pollution in Parkinson's disease.

Histopathological and Clinical Features of HER2-Positive Breast Cancers across Hormone Receptor Subgroups: A Cross-Sectional Analysis.

Regulation of Dormancy-Associated Genes dosR by TetR Family Regulator MRA_0776 in Mycobacterium Tuberculosis H37Ra.

Machine learning-assisted analysis of serum metabolomics for identifying biomarkers in intrinsic and idiosyncratic drug-induced liver injury.

In Silico, In Vitro, and In Vivo Antidiabetic Activity of an Alkaloid, 1, 2-Dimethoxy-12-Methyl-7-(3-Methylbut-2-en-1-yl)-12, 13-Dihydro [1,3] Benzodioxolo [5,6-c] Phenanthridin-13-ol, Isolated From a Zimbabwean Herbal Antidiabetic Medicine.

Final Efficacy and Safety Results of Pyrotinib Combined With Trastuzumab and Chemotherapy in Pre-Treated Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer.

Repositioning of nonsedating antihistamine Ebastine for anti-lung adenocarcinoma based on EGFR/ERBB2 dual-targeting strategy.

Inflammation-Related alterations in tyrosine metabolism are associated with anhedonia and reduced motivation in Obesity: Influence of Early-Life adversity.

Metabolomics reveals early pregnancy serum metabolic changes and predictive biomarkers in gestational diabetes mellitus.

Unbiased characterization of COVID-19 endotypes leads to prognostication of high-risk individuals using routine blood tests.

Switching cell wall-bound polysaccharides to secreted polysaccharides in lactobacilli.

SYK-dependent lipid handling in monocyte-derived macrophages governs functional recovery after spinal cord injury.

Design of potent, proteolytically stable stapled lipopeptide analogues of BimBH3 as PTP1B inhibitors for diabetes therapy.

Cannabisin A and B from hemp seed hulls improve glucose homeostasis by re-engaging insulin, leptin, and AMPK pathways via selective PTP1B inhibition.

Research progress of PTP1B inhibitors and degraders.

Real-world effectiveness of palbociclib in combination with an aromatase inhibitor in HR+/HER2- bone-only metastatic breast cancer.

Harpin Ea protein confers top rot resistance in Rosa roxburghii Tratt. through synergistic activation of structural defenses and the phenylpropanoid-flavonoid pathway.

Genotype-Dependent Effects of Silicon on Cell Wall Composition and Antioxidant Responses in Oats Under Nitrogen Deficiency.

Angiogenic Imbalance in Preeclampsia: Profiling VEGF A, sFlt1, PlGF, and sFlt1/PlGF Ratios.

Heterogeneity of Hormone Receptors and HER2 in Breast Cancer Cutaneous Metastases: An Institutional Experience.

Zebrafish PRL-3 Regulates Yolk Syncytial Layer Integrity and Actomyosin Contractility During Epiboly.

HER2 Alterations in Non-Small Cell Lung Cancer: Emerging Perspectives on the Therapeutic Landscape.

Out of Nucleus: Serine 727 Phosphorylation Orchestrates Non-Canonical STAT3 Functions-Relevance to Triple-Negative Breast Cancer.

Deletion of TRPA1 Ion Channel Modulates the Central Stress Responses in a Mouse Model of Posttraumatic Stress Disorder.

Redox-primed biocontrol application reshapes Fusarium wilt resistance and metal homeostasis in tomato under arid conditions.

Beyond numbers: rethinking human milk fortification in preterm nutrition.

Nintedanib Lacks Efficacy in a Spirometry-Confirmed and Bleomycin-Induced Mouse Model of Idiopathic Pulmonary Fibrosis.

Blood Based Biomarkers for Predicting Treatment Response to Immune Checkpoint Inhibitors After EGFR-TKI Resistance in Non-Small Cell Lung Cancer.

Multidisciplinary therapy managements in endometrial and renal cancer patients treated with pembrolizumab and lenvatinib: a virtuous circle between oncologists and organ specialists.

Rosa roxburghii Tratt. enhances fracture healing through multitarget regulation of osteogenesis and angiogenesis: Integrated network pharmacology and molecular docking analysis.

Molecular imaging of tucatinib-induced cellular and TME changes in preclinical models of HER2 + breast cancer.

[New ways in interdisciplinarity: internal medicine meets human genetics : When frequent conditions become rare and rare conditions become frequent].

Evaluation of RC48-ADC in Combination with PRaG Regimen: An Open-Label, Prospective, Multicentre Study Assessing Efficacy and Safety for Advanced Refractory HER2-Expressing Solid Tumors (PRaG3.0 Study Protocol).

Novel Deiodinase 2-Selective Inhibitors-Possible Reference Substances for Regulatory In Vitro Tests for Endocrine Disruptors and Drugs Targeting T3-Dependent Processes.

Perioperative EGFR-Targeted Therapy in Resectable EGFR-Mutated NSCLC: A Narrative Review from Drug Design to Pain-Informed MRD-Guided Care.

Natural products as kinase inhibitors in lung cancer: molecular mechanisms, therapeutic potential, and clinical trials.

Melanin pigments protect nucleic acid integrity.

Effects of L-Tyrosine Ingestion on Endurance Performance in Mentally Fatigued Cyclists.

Targeting the Hippo pathway in pulmonary arterial hypertension: emerging pharmacological strategies.

Clinicopathological Spectrum and Biomarker Profile of Male Breast Cancer: A Retrospective Study from a Tertiary Care Center in South India.

Dopaminergic Modulation of Striatal Somatostatin Interneurons Shapes Motor Learning and L-DOPA-Induced Dyskinesia.

Overexpression of S100 Calcium-Binding Protein A2 is Associated With Poor Prognosis in Hepatocellular Carcinoma.

Serum Metabolomic Signature of Gliomas in an Indian Cohort: Identification of Grade-Specific Alterations and Potential Biomarkers.

NIPAL1 Drives a Metabolic-Epigenetic Feedback Loop to Promote Lactate-Mediated Immune Evasion in Esophageal Cancer.

Advancing Targeted Protein Degradation Through Immunoproteasome-Caged N-Degrons.

Integrated transcriptome and metabolome analysis reveals the molecular mechanism underlying differences in Psa resistance between Actinidia valvata and Actinidia chinensis.

Transcriptomic Analysis and Biocontrol Potential of Bacillus velezensis T25 against Fusarium Wilt of Banana.

[Analgesic mechanism of Entadae Semen based on its in vivo material basis and regulation of SRC-mediated microglial polarization in a rat model of chronic compression of dorsal root ganglion].

[Efficacy comparison of Atractylodis Macrocephalae Rhizoma with different growth years in treatment of slow transit constipation and its mechanism].

[Two new acyclic terpenoids from Croci Stigma].

[Panax notoginseng saponins mediated inhibition of human aortic valve interstitial cell calcification via SYK/NF-κB pathway].

[Baihe Dihuang Decoction attenuates hippocampal neuronal injury in anxious depression by inhibiting SHP2].

Tumour specific HORMAD1 expression perturbs mitotic arrest and drives sensitivity to mitotic kinase inhibitors.

Predictors of Pathologically Negative Sentinel Lymph Nodes and Recurrence-Free Survival in Women with Invasive Breast Cancer Treated with Neoadjuvant Chemotherapy.

Brain lipidomics identifies mitochondrial redox dysfunction and metabolic trade-offs associated with Parkinson's disease-like pathology induced by Nanoplastics exposure.

Revealing the transcriptional profile of fish muscle cells in vitro and in vivo: Insights to improve fish muscle culture.

NFIC suppressed the development of Glioma via modulating the balance of SHP2/PI3K and NF-κB/PTEN Signaling.

The Traditional Chinese Medicine Compound Hezi Qingyou Formula Controls the MAPK Signaling Pathway for Alleviating Gastric Ulcer Induced by Acetic Acid in Rats.

Lnc-CHRM4-2:1 Inhibits M2 Polarization and Efferocytosis of Macrophages by Downregulating MerTK and SLC2A1 in Rheumatoid Arthritis.

[Linking tetrahydrobiopterin depletion to ferroptosis: A novel mechanism of neurological injury in Hyperphenylalaninemia].

Tissue-level Consequences of Segmental Abnormalities in Hirudo verbana: A Morphological and Histological Approach.

Current evidence on non-surgical therapies for Dupuytren's disease: A clinical review.

Slipping Through the Chasm of Multicenter Hand-offs-Rare Incidence of Nintedanib Induced Renal Failure: Case Report.

PKC-iota drives EGFR-TKI resistance in EGFR-mutated NSCLC by phosphorylating FASN to reprogram lipid metabolism.

Patient-reported outcomes in NRG Oncology RTOG 1010: Phase 3 trial evaluating the addition of trastuzumab to trimodality treatment of HER2 overexpressing esophageal adenocarcinoma.

Strain-specific effects of lactic acid bacteria on rambutan juice fermentation: Insights from physicochemical, volatile, and non-volatile profiles.

ALK-positive, EBV-positive Large B-cell lymphoma in an HIV patient: a diagnostic pitfall mimicking plasmablastic lymphoma.

Targeted Profiling of Tryptophan- and Tyrosine-Derived Metabolites in Traditionally Fermented Foods.

Nup107 is a crucial regulator of torso-mediated metamorphic transition in Drosophila melanogaster.

Ceritinib Induces Mitochondrial Fragmentation in Thyroid Cancer Cells by Targeting Drp-1.

Engineering glyphosate tolerance in sugarcane through overexpression of a mutated version of its native EPSPS gene.

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1.

Immunosuppressive Tumor Microenvironment and Therapeutic Landscape of Diffuse Intrinsic Pontine Glioma.

Targeted therapy for ALK-positive histiocytosis masquerading as optic nerve tumor: a case report.

The Innovative Multi-Marker Selection System Based on Tyrosine Synthesis Pathway for Monoclonal Antibody Expression in CHO Cells.

Identification and characterization of a wet adhesive protein extracted from Dreissena bugensis, the freshwater quagga mussel.

Cardiotoxic Effects of Osimertinib Compared to Other EGFR Inhibitors: A Systematic Review and Meta-Analysis.

Effects of Music Therapy Combined with Hospital-Community Integrated Care on the Psychological Status of Patients with Parkinson's Disease Treated with Pramipexole and Levodopa.

PTPN1 Regulation via YBX1-PTBP1 Interaction Promotes Fibroblast Activation and Fibrotic Remodeling in the Lung.

Small metabolites vary in sow milk across the course of lactation, while moringa supplementation and cooling sows exposed to heat stress conditions have limited effects.

Amenability of the Gatekeeper Enzyme HphA to Engineering in the Homologation Pathway of l‑Phenylalanine and l‑Tyrosine through Homology-Based Site-Directed Mutagenesis.

Critique of phase II agents for non-small cell lung cancer: what is our clinical need and which agents have potential?

High-throughput screened kaempferitrin potentiates trastuzumab efficacy in HER2-positive gastric cancer by targeting Cyclooxygenase-2 to inhibit ERK signaling.

The H2S donor sulforaphane inhibits NLRP3 inflammasome activation by inducing mitochondrial autophagy and mitigating CBS-H2S axis damage in in-vitro and in-vivo models of Parkinson's disease.

[Correlation of STAT6 and HER2-low expression with clinicopathological features and prognosis in triple negative breast cancer].

[FGFR1 mRNA expression in different molecular subtypes of breast cancer].

S(-II) enhances Cd adsorption to release 2,3-dihydroxybenzoylserine and alleviate Fe(III)-induced ROS in high-siderophore-yielding bacteria.

A bis-phosphorylated peptide wrangles the SHP2 tandem SH2 domains into shape.

High-density branched α-amylase hydrolyzates from α-glucans exhibit distinct glucose and appetite-regulatory functions in vivo.

Functional evaluation of a Staphylococcus vitulinus protease: Biochemical properties, structural adaptation, and application in myofibrillar proteins.

Effect of solid-state fermentation on protein content, amino acid digestibility and anti-nutritional components of common beans, lentils and chickpeas.

Hepatoprotective potential of anthocyanins from purple highland barley bran against non-alcoholic fatty liver disease through gut-liver axis.

Dose- and sex-related effects of the MAGL inhibitor MCH11 on binge-like ethanol consumption in mice.

Bupleurum chinense DC. ameliorates depression through hepatic lipopolysaccharide-binding protein-associated inflammation and monoamine biosynthesis.

QM/MM study of the catalytic reaction of potato epoxide hydrolase.

Dual Stress Postischemia Deprivation Depression via Metabolic Disturbance in Rodents.

Differential Clinical Outcomes of Palliative Radiotherapy among Different Molecular Subtypes of Metastatic Breast Cancer: A Prospective Study.

Pertuzumab and Pathological Complete Response in Early HER2+ Breast Cancer: A Systematic Review and Meta-analysis of Real-World Studies.

Integrative metabolomics and network pharmacology reveal the antifibrotic mechanisms of Gurigumu-13 in a rat model of hepatic fibrosis.

Impact of sulfamethoxazole, trimethoprim, diclofenac, carbamazepine, and their mixture on the metabolism of Lemna minor: a targeted metabonomic study.

Metabolomic profiling in phenylketonuria: a systematic review of human studies.

A novel triaptosis-related prognostic signature to assess the clinical value in HER2-low breast cancer: evidence from clinical cohorts and experimental validation.

The clinical value of [18F]-fluoro-ethyl-L-tyrosine PET ([18F]FET-PET) correlated with MRI in patients with functioning pituitary adenomas: an observational cohort study.

DDR2 ameliorates nonalcoholic hepatic steatosis by activating the AMPK/ACC pathway.

Targeting tRNA-dependent tyrosine usage unveils a metabolic vulnerability in hepatocellular carcinoma.

Molecular and Epidemiological Insights into Oral Squamous Cell Carcinoma: Biomarker Profiling for Prognostic and Therapeutic Advancements.

ET-1-induced CTGF expression is mediated by STAT3 activation through casein kinase 2α' and p300 but not casein kinase 2α in human lung fibroblasts.

Interactions and communications in hepatocellular carcinoma: Potential targets for chemo/radiosensitization.

Analysis of Large Language Model Decision Making in Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Early Breast Cancer.

The causal relationship and metabolic mediation between telomere length and intervertebral disc degeneration: A two-stage network Mendelian randomization study.

The expression of tyrosine kinase and threonine promotes the progression of lung adenocarcinoma and is linked to a negative prognosis.

Simultaneous quantification of lifitegrast and Rebamipide in hydrogel-based contact lenses using spectroscopic method.

IL‑6: A key player in the EGFR‑TKI‑resistant tumor microenvironment and its therapeutic implications (Review).

Framework-mediated binding of foreign and self-glycans by IGHV4-34 antibodies.

Tailoring low-dose aspirin to prevent preeclampsia: translational and biomarker insights.

Sex and Diet Biased Effect of L-DOPA on Iron Accumulation in the Ventral Midbrain.

Structure-Activity Studies of a Novel Opioid Cyclic Hexapeptide Modified at Gly3: Identification of Highly Potent Agonists or Antagonists of Opioid Receptors.

Matrix micro/nano-topography drives oncogenic signaling and drug response in a 3D osteosarcoma model.

A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases.

[Exploring the therapeutic targets and molecular mechanisms of pimecrolimus in the treatment of oral lichen planus based on network pharmacology, machine learning, and molecular docking].

Aptamer-Mediated Proximity Labeling (ApMPL) for Spatially Resolved Deciphering of Cell Membrane Protein Interactomes.

Src-family kinase control of CAR signaling: the paradoxical and multifaceted role of LCK.

Percutaneous hepatic perfusion combined with ipilimumab and nivolumab for metastatic uveal melanoma (CHOPIN): a single-centre, open-label, randomised, phase 2 trial.

Antigen-induced IL-12 potentiates piggyBac-engineered HER2-CAR-T cells against gastric cancer.

Biocontrol potential and mechanism of endophytic Bacillus velezensis WSR1 against rubber tree anthracnose.

Conformation-Sensitive Active-Site Residue Tyrosine 260 in Paenibacillus macerans Cyclodextrin Glycosyltransferase Governs C13-Regioselective Glycosylation of Rebaudioside A.

Characterization of the TREM-1 signaling landscape in human neutrophils.

Metabolic and behavioral effects of neurofibromin result from differential recruitment of MAPK and mTOR signaling.

Nivolumab plus ipilimumab for hepatocellular carcinoma: a game-changer?

Nintedanib enhances the antitumor efficacy of pd-1 blockade, potentially through inhibition of myeloid-derived suppressor cells and cancer-associated fibroblasts.

Histidine and tyrosine residues are targets for SIRT6 ADP-ribosylation activity.

Mislocalisation of FLT3-ITD receptor contributes to MV4-11 leukaemia cell resistance to antibody-drug conjugate.

Early-life adversity induces metabolic alterations in a rodent model of depression: a differential stress response perspective.

Case Report: Glofitamab in the treatment of a patient with central nervous system-involved Burkitt lymphoma.

Stratified signaling network remodeling of kinase-transcription factors' interactions in Parkinson's disease.

Advanced Parkinson's disease treatment patterns in Italy: results from a multicenter observational study.

A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Fenebrutinib and Effect on the QT/QTc Interval in Healthy Participants.