Perda de cabelo geralmente no couro cabeludo. Pode resultar em manchas calvas ou espalhar-se por todo o couro cabeludo ou toda a epiderme. Pode ser androgenética ou causada por agentes quimioterápicos, puxões compulsivos de cabelo, doenças autoimunes ou condições congênitas.
Introdução
O que você precisa saber de cara
Perda de cabelo geralmente no couro cabeludo. Pode resultar em manchas calvas ou espalhar-se por todo o couro cabeludo ou toda a epiderme. Pode ser androgenética ou causada por agentes quimioterápicos, puxões compulsivos de cabelo, doenças autoimunes ou condições congênitas.
Tem tratamento?
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Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 89 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 249 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
14 genes identificados com associação a esta condição.
Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688)
Cytoplasm, cytosolCytoplasmEndoplasmic reticulum
Hypotrichosis 12
A form of hypotrichosis, a condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The extent of scalp and body hair involvement can be very variable, within as well as between families. HYPT12 patients have normal scalp hair density at birth. Hair loss begins during the first 6 months of life and gradually progresses to nearly complete loss of scalp hair. The remaining hairs grow slowly and are thin, sparse, dry, and fragile. Body hair, axillary and pubic hair, eyebrows and eyelashes are also sparse or absent. HYPT12 inheritance is autosomal dominant.
Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture
Cell membrane
Woolly hair autosomal recessive 1 with or without hypotrichosis
A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals exhibit features of hypotrichosis.
Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (PubMed:14766201, PubMed:26200341, PubMed:7639730). Through the production of lanosterol may regulate lens protein aggregation and increase transparency (PubMed:26200341)
Endoplasmic reticulum membrane
Cataract 44
An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.
Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway (PubMed:10783161, PubMed:16630891, PubMed:25137548, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). Acts as a scaffolding protein in the SMP complex (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' o
CytoplasmNucleus
Noonan syndrome-like disorder with loose anagen hair 1
A syndrome characterized by Noonan dysmorphic features such as macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck, pectus anomalies, in association with pluckable, sparse, thin and slow-growing hair.
Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG)
SecretedCell membrane
Hypotrichosis 7
A condition characterized by the presence of less than the normal amount of hair. Affected individuals have sparse or absent scalp, axillary and body hair and sparse eyebrows and eyelashes. HYPT7 inheritance is autosomal recessive.
A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function (PubMed:19717567). Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage (By similarity). Essential for successful comple
Cell membraneCell junction, desmosomeCytoplasm
Hypotrichosis and recurrent skin vesicles
A disorder characterized by hypotrichosis and the appearance of recurrent skin vesicle formation. Affected individuals show sparse and fragile hair on scalp, as well as absent eyebrows and eyelashes. Vesicles filled with thin, watery fluid are observed on the scalp and skin of most of the body. Mucosal vesicles are absent.
An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the beta chain HLA-DRB, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells
Cell membraneEndoplasmic reticulum membraneEarly endosome membraneLate endosome membraneLysosome membraneAutolysosome membrane
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23246290, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed
Cytoplasm, cytosolNucleus
Hypotrichosis 11
A form of hypotrichosis, a condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The extent of scalp and body hair involvement can be very variable, within as well as between families. HYPT11 is an autosomal dominant form characterized by scanty or absent eyebrows and a highly variable degree of alopecia since birth, ranging from slight thinning of scalp and axillary hair to complete loss of scalp and body hair. Pubic hair remains mainly unaffected.
Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis
Cell membrane
Hypotrichosis 1
A rare form of non-syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age. HYPT1 inheritance is autosomal dominant.
A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity). Plays a role in moderating lymphocyte migration to inflamed skin and maintaining homeostasis of the epidermal inflammatory response (By similarity)
Cell membraneCell junction, desmosome
Hypotrichosis 6
A condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The disorder affects the trunk and extremities as well as the scalp, and the eyebrows and eyelashes may also be involved, whereas beard, pubic, and axillary hairs are largely spared. In addition, patients can develop hyperkeratotic follicular papules, erythema, and pruritus in affected areas. In some patients with congenital hypotrichosis, monilethrix-like hairs showing elliptical nodes have been observed. HYPT6 inheritance is autosomal recessive.
Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable)
Woolly hair autosomal dominant
A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends.
Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle
Nucleus
Alopecia universalis congenita
A rare disorder characterized by loss of hair from the entire body. No hair are present in hair follicles on skin biopsy.
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structu
CytoplasmNucleusNucleus, nucleoplasmNucleus, nucleolus
Noonan syndrome-like disorder with loose anagen hair 2
A syndrome characterized by Noonan dysmorphic features such as macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck, pectus anomalies, in association with pluckable, sparse, thin and slow-growing hair.
Important for the epidermal barrier integrity
Secreted
Hypotrichosis 2
A condition characterized by the presence of less than the normal amount of hair. Affected individuals have normal hair in early childhood but experience progressive hair loss limited to the scalp beginning in the middle of the first decade and almost complete baldness by the third decade. Body hair, beard, eyebrows, axillary hair, teeth, and nails develop normally. HYPT2 inheritance is autosomal dominant.
Medicamentos e terapias
Mecanismo: Sulfonylurea receptor 2, Kir6.2 opener
Mecanismo: TEC family kinase inhibitor
Mecanismo: Steroid 5-alpha-reductase 2 inhibitor
Mecanismo: Prostanoid FP receptor agonist
Mecanismo: Androgen Receptor antagonist
Mecanismo: Tyrosine-protein kinase JAK2 inhibitor
Mecanismo: Tyrosine-protein kinase JAK2 inhibitor
Mecanismo: Glucocorticoid receptor agonist
Mecanismo: TEC family kinase inhibitor
Variantes genéticas (ClinVar)
287 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 1,337 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
60 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Alopecia
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
🟢 Recrutando agora
16 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.
Outros ensaios clínicos
689 ensaios clínicos encontrados, 36 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 12.896
Frequency and associated factors of herpes zoster infection in SLE patients from Latin America: data from the GLADEL 2.0 cohort.
Este estudo revelou uma alta incidência de Herpes Zoster (HZ) em pacientes latino-americanos com Lúpus Eritematoso Sistêmico (LES), sendo uma preocupação significativa. A ocorrência de HZ está associada a maior atividade da doença, uso de altas doses de prednisona, manifestações neuropsiquiátricas como psicose e convulsões, e também foi observada maior frequência de **alopecia** nesses pacientes. Para pacientes e médicos, é crucial estar atento: mulheres, doença mais ativa e uso de prednisona são preditores independentes de HZ, o que exige uma estratificação de risco proativa e vigilância, especialmente em pacientes com lúpus mais grave ou em terapia com corticoides.
🇧🇷 traduzidoAn updated guide to hair follicle stem cell markers and changes in their expression with aging.
Este artigo científico oferece um guia atualizado sobre os marcadores das células-tronco do folículo piloso (HFSCs), essenciais para sua identificação e manipulação. Para pacientes e médicos, compreender esses marcadores é crucial para o desenvolvimento de novas terapias e a regeneração capilar em casos de alopecia, inclusive considerando as mudanças na expressão desses marcadores com o envelhecimento.
🇧🇷 traduzidoTrusting your gut: a hairy situation-gastric trichobezoar case report.
Este artigo descreve um tricobezoar gástrico, uma massa rara de cabelo ingerido, comum em meninas jovens, que pode causar dor abdominal e perda de peso, frequentemente confundidos com outras condições. O diagnóstico é desafiador e pode ser tardio, especialmente na ausência de alopecia visível ou histórico psiquiátrico, pois exames iniciais são frequentemente inconclusivos. Para pacientes e médicos, é crucial considerar o tricobezoar no diagnóstico diferencial de sintomas abdominais inespecíficos em crianças, sendo a endoscopia digestiva alta (EDA) fundamental para a confirmação.
🇧🇷 traduzidoPharmacokinetics and Analgesic Efficacy of a Novel Extended-Release Buprenorphine Formulation in Mice.
Este artigo descreve a avaliação de uma nova formulação de buprenorfina de liberação prolongada (Bup ER) em camundongos, que demonstrou proporcionar analgesia pós-operatória eficaz por 48 a 96 horas com uma única dose, mantendo níveis plasmáticos do medicamento por até 120 horas. Para pacientes e médicos, isso sugere um potencial para um manejo da dor prolongado e menos frequente. Os efeitos adversos foram geralmente leves e locais, como vermelhidão ou alopecia (perda de pelo) no local da injeção, sendo que lesões mais graves foram atribuídas à técnica de aplicação e não ao medicamento em si.
🇧🇷 traduzidoCombined itraconazole and terbinafine therapy for pediatric kerion: a report of two cases.
Este artigo relata dois casos de quério pediátrico (uma infecção fúngica do couro cabeludo que causa massas purulentas e alopecia), destacando que a condição é frequentemente mal diagnosticada como infecção bacteriana devido à sua raridade, resultando em atrasos e tratamentos iniciais ineficazes. Os casos demonstraram, no entanto, que após um diagnóstico etiológico correto, a terapia antifúngica combinada com itraconazol e terbinafina é altamente eficaz, levando à resolução completa. Isso enfatiza a importância crucial de médicos considerarem etiologias fúngicas em lesões purulentas do couro cabeludo em crianças e buscarem testes específicos para garantir um tratamento precoce e bem-sucedido.
🇧🇷 traduzidoPublicações recentes
A Unique Case of Lupus Erythematosus Profundus Presenting With Localized Scarring Alopecia and Perioral Swelling in a Pediatric Patient.
Dental Rehabilitation of a Child Diagnosed With Alopecia Areata Totalis: A Case Report.
🥉 Relato de casoSkin toxicity induced by chemotherapy or molecular targeted therapy combined with immune checkpoint inhibitors in Asian patients: A literature review by the Japanese Pharmacist-led Oncodermatology Study Team.
🥉 Relato de casoHow Long to Treat to Achieve Desired Treatment Outcomes with Baricitinib 4 mg in Severe Alopecia Areata: Evidence-based Approach.
Time to Maximal Response with Low-Dose Oral Minoxidil in Clinical Treatment of Androgenetic Alopecia.
📚 EuropePMC12.606 artigos no totalmostrando 195
Effectiveness and Safety of Topical Finasteride for Male Androgenetic Alopecia: Real World Data.
International journal of dermatologyStepwise topical corticosteroid and dexamethasone rescue strategy enhances baricitinib outcomes in severe alopecia areata: real-life clinical experience.
European journal of dermatology : EJDFrequency and associated factors of herpes zoster infection in SLE patients from Latin America: data from the GLADEL 2.0 cohort.
Lupus science & medicineSustained Remission of Alopecia Areata Universalis following Red Cell Transfusion.
Irish medical journalUpadacitinib for the Treatment of Systemic Immune Co-Morbidity in One Case: Alopecia Areata, Vitiligo, Ankylosing Spondylitis, and Allergic Rhinitis-Asthma - Multifaceted Control.
Clinical, cosmetic and investigational dermatologyCase Report: Vitiligo and Alopecia Universalis Following Rituximab Therapy in a Patient with Myasthenia Gravis.
Clinical, cosmetic and investigational dermatologyChemotherapy and the Skin: Understanding Dermatologic Side Effects.
CureusChemotherapy-Induced Toxicities in Pediatric Cancer Patients: A Cross-Sectional Survey Using a Child- and Caregiver-Reported Outcome Tool in Tanzania.
Drug, healthcare and patient safetyBilateral ovarian steroid cell tumor in a postmenopausal woman with progressive hyperandrogenism.
JCEM case reportsTransient Neonatal Zinc Deficiency due to Maternal Variants in SLC30A2: An Emerging and Atypical Candidate Gene for Maternal Carrier Screening.
American journal of medical genetics. Part APost-finasteride syndrome: survey of dermatologists from the Spanish Hair and Nail Disorders Group.
Actas dermo-sifiliograficasEthical Considerations of Excusing Students With Alopecia Areata From Physical Education Activities.
Journal of the American Academy of DermatologyReduced Prostate Cancer Risk in Patients with Androgenetic Alopecia Using 5-Alpha Reductase Inhibitors: A TriNetX Real-World Cohort Study.
Journal of the American Academy of DermatologyEffective treatment of alopecia areata and psoriasis with baricitinib.
The British journal of dermatologyReal-World Evidence of Baricitinib in Severe Alopecia Areata: Insights From a Spanish Case Series.
Actas dermo-sifiliograficasRecombinant Filaggrin-2 microneedles reverse androgenetic alopecia by rescuing mitochondrial dysfunction in dermal papilla cells.
International journal of biological macromoleculesAcupuncture for treating alopecia areata: A systematic review and meta-analysis.
MedicineA rare variant of lichen planopilaris: Familial Graham-Little-Piccardi-Lassueur syndrome in Saudi Arabia.
JAAD case reportsPerifollicular Inflammation and Fibrosis in Androgenetic Alopecia: Implications for Diagnosis and Treatment - A Comparative Histopathologic and Clinical Study with Normal-Appearing Scalp.
Clinical, cosmetic and investigational dermatologyEarly-onset recipient-site necrosis after FUE hair transplantation complicated by Pseudomonas aeruginosa infection: a case report.
Journal of surgical case reportsIncreased risk of hair loss with GLP-1 receptor agonists: A real-world multicenter TrinetX cohort study.
JAAD internationalFinesse in Forehead Lifting-Asymmetric Ligament Release for Asymmetric Brow Ptosis.
Aesthetic plastic surgeryDermatological Adverse Events Associated With Lapatinib Treatment in Dogs With Urothelial Carcinoma: A Retrospective Study.
Veterinary dermatologyS3 guideline diagnostics and therapy of alopecia areata - Part 1: Diagnostics and epidemiology.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDGRitlecitinib for Severe Alopecia Areata: A 24-Week, Multicentre, Real-World Study.
American journal of clinical dermatologyCirculating MicroRNA Signatures in Severe Alopecia Areata: Diagnostic Discrimination, Pathway Analysis, and Therapeutic Implications.
Dermatology and therapyAn updated guide to hair follicle stem cell markers and changes in their expression with aging.
JID innovations : skin science from molecules to population healthAddisonian Crisis in a 39-Year-Old Woman With Primary Adrenal Insufficiency.
CureusPrecision therapeutics in non-scarring alopecia: a systemic genomic and pathway-based framework for targeted interventions.
ADMET & DMPKConvergent Regenerative Strategies in PM&R for Musculoskeletal and Hair Restoration: Integration of PRP, Exosomes, and Physical Modalities.
Archives of internal medicine researchClinical, Histopathological and Epidemiological Features of Dorsal Melanotrichia of Poodles and Poodle Crosses.
Veterinary dermatologyThe efficacy of scalp cooling in patients receiving chemotherapy for primary gynecologic cancers: a randomized controlled trial.
Scientific reportsComorbidities in Discoid Lupus: A Systematic Review and Meta-analysis of Prevalence and Association.
Dermatology and therapySkin bacteriota ameliorates androgenetic alopecia via harmonizing skin immuno inflammatory balance.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]Implications of Dermatologic Disorders in Facial Cosmetic Surgery: A Systematic Review.
Annals of plastic surgeryFrontal fibrosing alopecia and lichen planopilaris: epidemiology, treatment, and remission rate (2014-2024).
Dermatology reportsManagement of classic lichen planopilaris: The EADV task force on hair diseases position statement.
Journal of the European Academy of Dermatology and Venereology : JEADVTreatment Outcomes of Lipedematous Scalp and Lipedematous Alopecia: A Systematic Review.
International journal of dermatologyScalp Alopecia After Greater Occipital Nerve Block Administration Mimicking Alopecia Areata.
The American Journal of dermatopathologyEffect of Palliative Treatment and Viddhakarma (Puncture Therapy in Ayurveda) in an Androgenetic Alopecia (Khalitya)-A Case Report.
Journal of pharmacy & bioallied sciences[Discussion on the treatment of seborrheic alopecia with acupuncture and moxibustion based on the theory of zhuoxie haiqing].
Zhongguo zhen jiu = Chinese acupuncture & moxibustionTrusting your gut: a hairy situation-gastric trichobezoar case report.
Frontiers in pediatricsGastrointestinal bezoars: two distinct cases illustrating diagnostic and surgical challenges.
International journal of surgery case reportsClinical, trichoscopic, and histological characteristics of 46 hispanic men with fibrosing alopecia in a pattern distribution: a retrospective multicenter analysis.
Frontiers in medicineComparative efficacy of oral dutasteride and low-, medium-, and high-dose oral minoxidil: a six-month prospective trichoscopic and clinical study.
Frontiers in medicineThe Early Cost-Effectiveness of a Novel Scalp Cooling Device to Alleviate Chemotherapy-Induced Alopecia in Patients with Early Breast Cancer.
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Frontiers in oncologyA Nonrandomized Clinical Trial Investigating Keratinocyte Growth Factor-Hair Serum for the Prevention of Chemotherapy-Induced Alopecia.
Journal of cosmetic dermatologyUV Protection Habits and Preferences in Patients With Distinct Cutaneous Immune-Mediated Inflammatory Diseases.
Photodermatology, photoimmunology & photomedicinePost-marketing safety of CGRP monoclonal antibodies and gepants: A systematic review of spontaneous reporting system data.
HeadachePharmacokinetics and Analgesic Efficacy of a Novel Extended-Release Buprenorphine Formulation in Mice.
Journal of the American Association for Laboratory Animal Science : JAALASPrescribing Habits for Androgenetic Alopecia among Dermatologists in Spain in 2024: A Cross-Sectional Study.
Actas dermo-sifiliograficasReal-World Safety of JAK Inhibitors in Skin Immune-Mediated Inflammatory Diseases: Boxed Warning Outcomes from a Multinational Cohort Study.
Clinical pharmacology and therapeuticsChemotherapy-Induced Alopecia in Breast Cancer Patients: Treatment-Specific Incidence and Risk of Persistent Hair Loss.
CancersAdvances in Medicalized Hair Loss Solutions: A Review of Current Clinical Practices and Regenerative Medicine-Based Protocols with Focus on Off-Label Injectable Treatments.
Journal of clinical medicineAlopecia after GLP-1 agonist therapy: A TriNetX Database active comparator retrospective cohort study.
Journal of the American Academy of DermatologyDeletion of vitamin D receptor with calcium sensing receptor in keratinocytes promotes epidermal tumorigenesis by limiting dna repair and oxidative stress response genes.
The Journal of steroid biochemistry and molecular biologyNon-Invasive Scalp Tape-Strip RNA Sequencing Captures Disease Activity and Treatment-Response Signatures in Alopecia Areata.
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International journal of dermatologyUse of Castor Oil in Dermatology: A Narrative Review.
CureusOxidative Stress and Hormone-Regulated Dermal Papilla Cell-Targeted Nanomodulators: Reverse Cellular Senescence for Androgenetic Alopecia Therapy.
Biomaterials researchBioorthogonal Click-Engineered Microneedle Patch Enables Adeno-Associated Virus-Mediated Dermal Acidic Fibroblast Growth Factor Expression for Hair Loss Treatment.
ACS nanoFerulic acid promotes hair growth via estrogen receptor alpha activation in cultured human dermal papilla cells.
Scientific reportsLactiplantibacillus plantarum ZJUIDS51 improves androgenic alopecia via gut-skin axis.
Food research international (Ottawa, Ont.)Association between Androgenic Hair Patterns and Prostate Cancer Risk in South Indian Men: A Case-control Study from the Cauvery Delta.
The Journal of the Association of Physicians of IndiaCase Report: Multimodal contact immunotherapy in alopecia areata: long-term clinical experience in the JAK inhibitor era.
Frontiers in medicineCase Report: PTCH1 splice-site mutation and sonidegib treatment in Gorlin-Goltz syndrome: clinical insights from a family case study.
Frontiers in medicinePruritus in Hemodialysis Patients in a Sub-Saharan African Country: Benin-Associated Skin Conditions and Other Factors in 2023 in Three Hemodialysis Centers.
Dermatology research and practiceReal-World Efficacy of Ritlecitinib in Adolescent Patients With Alopecia Areata: A 36 Week Monocentric Real-Life Observational Study.
Journal of cutaneous medicine and surgerySequential Small-Molecule Therapy for Lymphocytic Cicatricial Alopecia: A Multicenter Prospective Cohort Pilot Study.
Journal of the American Academy of DermatologyConsensus Document on the Clinical Management of Alopecia Areata: Recommendations from the Spanish Hair Research Group of the Spanish Academy of Dermatology and Venerology).
Actas dermo-sifiliograficasPresentations of Cutaneous Disease in Various Skin Pigmentations: Keratosis Pilaris.
HCA healthcare journal of medicineCombined itraconazole and terbinafine therapy for pediatric kerion: a report of two cases.
Translational pediatricsInvestigating tralokinumab-related adverse events in treating atopic dermatitis: insights from the FAERS database.
Frontiers in immunologyRevisiting Contact Sensitization Among Patients With LPP/FFA: Cross-Sectional Findings From 55 Cases.
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CureusCost-Effectiveness Analysis of Ritlecitinib Compared With No Treatment in Patients With Severe Alopecia Areata in Japan.
The Journal of dermatologyThe most impactful aspects of living with alopecia areata among patients commencing systemic treatments: Evaluating patients' perspectives to guide therapy.
Clinical and experimental dermatologyGenerative Artificial Intelligence Tools: Evaluating Ways to Automate Your SALT (GATEWAYS) Scoring of Alopecia Areata.
Pediatric dermatologyTreatment Patterns and Health-Related Quality of Life in Patients with Alopecia Areata Stratified by Disease Severity in the USA.
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The Journal of investigative dermatologyNanozyme Catalysis Restores Hair Follicle Integrity by Reversing Peroxisomal Collapse.
ACS nanoAlopecia Areata in a Patient Undergoing Treatment for Secondary Syphilis: A Diagnostic Challenge.
CureusCrisaborole as a Potential Treatment for Pediatric Alopecia Areata: A Case Report and Literature Review.
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Prenatal diagnosisHormonal Contraceptives: Part II- Use and Relevance in Clinical Dermatology.
Journal of the American Academy of DermatologyInsurance-Driven Switching and Real-World Treatment Outcomes of Janus Kinase Inhibitors in Alopecia Areata: A Retrospective Cohort Study.
Journal of the American Academy of DermatologySerum ferritin and hair iron content in correlation to hair diameter and density: a case-control study.
Dermatology reportsClinical and trichoscopic features of early congenital syphilis: a single-center cross-sectional study.
Frontiers in medicineAlterations of white matter connectivity in alopecia areata patients.
Brain imaging and behaviorSkin Commensal Microbiota Does Not Influence the Clinical Course of Dermatophyte Infection in Persian Cats.
Veterinary dermatologyEarly androgenetic alopecia as a possible indicator of diabetes mellitus and its link to cardiovascular risks: a cross-sectional study.
Journal of the American Academy of DermatologyGlobal, regional, and national burden of alopecia areata in adolescents and young adults aged 10-24 years from 1990 to 2021: a trend analysis.
Frontiers in public healthSignificant improvement with ivarmacitinib after suboptimal response to tofacitinib in severe alopecia areata: a case report and literature review.
Frontiers in immunologyLow-dose oral minoxidil (LDOM) and topical minoxidil: consensus recommendations for managing male and female pattern hair loss in hair transplant patients using a modified Delphi process.
Expert opinion on pharmacotherapyHighlights from JAAD Case Reports: May 2026.
Journal of the American Academy of DermatologyExploring novel management options for alopecia areata.
The American journal of managed careRecyclable Polymerizable Deep Eutectic Solvent-Based Three-Dimensional-Printed Dissolving Microneedles with pH-Responsive Delivery of ZIF-8-Loaded Minoxidil for Hair Loss Therapy.
ACS applied materials & interfacesEyebrow Madarosis: An Updated Review of the Etiology and Management, Part I - Nonscarring Disorders.
Journal of drugs in dermatology : JDDEfficacy, Safety, and Real-World Aspects of Janus Kinase Inhibitors to Treat Patients With Alopecia Areata.
Journal of drugs in dermatology : JDDPersistent Alopecic Patches Following Dutasteride Mesotherapy for Female Androgenetic Alopecia: A Case Series.
Journal of drugs in dermatology : JDDUpdates on Therapeutic Approaches for Management of Androgenetic Alopecia: A Review.
Journal of drugs in dermatology : JDDEmerging Therapeutic Strategies in Central Centrifugal Cicatricial Alopecia: A Review of the Clinical Trial Landscape.
Journal of drugs in dermatology : JDDFrom Bald to Bold: Reversal of Alopecia Totalis in an Adolescent Using Dupilumab Monotherapy.
Journal of drugs in dermatology : JDDRegrowth of Eyebrows in a Previous Steroid Non-Responder With Alopecia Universalis After Ritlecitinib Treatment.
Journal of drugs in dermatology : JDDBaricitinib-Related Adverse Events in Alopecia Areata and Rheumatoid Arthritis: A Comparative Study.
Journal of drugs in dermatology : JDDPatient Perspectives and Attitudes Toward the Diagnostic Process for Central Centrifugal Cicatricial Alopecia.
Journal of drugs in dermatology : JDDTargeting Endogenous Wnt Antagonists for Therapy Development in AGA: a Focus on DKKs and sFRPs.
Stem cell reviews and reportsDevelopment of a Visual Extension of the Severity of Alopecia Tool (VESALT) for Alopecia Areata.
Journal of the European Academy of Dermatology and Venereology : JEADVPatient-reported Outcomes of Adverse Events After Perioperative Chemotherapy for Breast Cancer: A Prospective Observational Study.
Cancer diagnosis & prognosisBeard hair response in alopecia areata universalis treated with baricitinib.
JAAD internationalDermatologists' Perspectives and Real-World Assessment of Alopecia Areata Severity in Adults in Taiwan: A Cross-sectional Survey.
Dermatology and therapyPediatric Radiation-Induced Alopecia Post Intracranial Vascular Malformation Embolization: A Case Report with Dermoscopic Findings.
Clinical, cosmetic and investigational dermatologyIndirect Exposure to Topical Minoxidil Causing Generalized Hypertrichosis in Children: A Report of Two Cases.
International journal of dermatologyFemale pattern hair loss.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienneA Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Study of Efficacy and Safety of Ashwagandha Root Extract Capsule on Skin and Hair Health in Healthy Adults.
Phytotherapy research : PTRUse of genetics in the prediction of success in male pattern hair loss therapy and mechanistic studies.
Frontiers in pharmacologyA real-world study of ublituximab based on the WHO-VigiAccess and U.S. food and drug administration's adverse event reporting system databases.
Frontiers in immunologyFinasteride-Loaded Phospholipid-Bile Salt Mixed Micelles for Targeted Follicular Delivery in Androgenetic Alopecia.
Journal of drug targetingSubsequent development of immune-mediated inflammatory diseases in patients with new-onset alopecia areata: An age-and sex-stratified cohort study using TriNetX.
Journal of the American Academy of DermatologyA comprehensive literature-based analysis of prognosis in patients with Cronkhite-Canada syndrome.
DigestionPhytochemical Profiling of the Halophyte Artemisia fukudo Makino and Its In Vitro Effects on Androgen-Related Pathways Associated With Benign Prostatic Hyperplasia and Alopecia.
ChemistryOpenFinasteride withdrawal induces anxiety-like behavior and novelty avoidance in adult male rats.
Journal of neuroendocrinologyArtificial Intelligence in Hair Disorders: A Narrative Review.
Dermatology and therapyA prospective study of hair transplantation combined with concentrated growth factors for the treatment of androgenetic alopecia.
The Journal of dermatological treatmentCoexistence of Friedreich's Ataxia and Esophageal Cancer: A Case Report.
Clinical case reportsDirect No-Shave Follicular Unit Excision (DNS FUE): A Modified Technique and Case Series.
CureusA Small-Molecule SLD1121 Activates Wnt/β-Catenin Signaling and Promotes Hair Growth via Targeting the Wnt Coreceptor LRP6.
JACS AuLarge-Scale Plasma Proteomics and Genetic Integration Uncover Novel Biological Pathways in Male Pattern Baldness.
International journal of molecular sciencesGenotype-Phenotype Delineation of Autoimmune Polyendocrinopathy, Candidiasis, and Ectodermal Dystrophy in a Pediatric Patient: A Case Report.
GenesOff-Label Treatment of Alopecia Areata-Retrospective Study.
BiomedicinesExosome-Based Therapeutics in Dermatology and Beyond: A Narrative Review.
BiomedicinesWeight Loss-Associated Alopecia Areata.
American journal of therapeuticsSingle-cell transcriptomics reveals hair growth retardation mediated by aberrant connective tissue sheath contraction in male androgenetic alopecia.
Nature communicationsDisparities in adverse event perception between patients and healthcare providers in gynaecologic anticancer therapy: results from an observational web-based study in Japan.
BMJ openHair morphology: An overlooked variable in alopecia drug trials.
Journal of the American Academy of DermatologyAssociated comorbidities in pediatric patients with alopecia areata.
Boletin medico del Hospital Infantil de MexicoPsoriasis Course in Patients with Alopecia Areata Undergoing Baricitinib Therapy.
Clinics and practiceThe Double-Edged Effect of Chronic Corticosteroid Use in Scarring Alopecia: A Call for Further Investigation.
International journal of dermatologySafety assessment of frunevetmab for osteoarthritis pain in cats: disproportionality analysis of the Food and Drug Administration Animal Drug Adverse Events database.
Journal of veterinary internal medicineCommunity Outreach for Hair Loss Education: A Pilot Feasibility Study.
International journal of dermatologyQuality of life and patient-reported side effects of low-dose oral minoxidil in treating female pattern hair loss.
The Journal of dermatological treatmentComprehensive single-cell transcriptomic profiling of the scalp from patients with moderate-to-severe alopecia areata.
The Journal of allergy and clinical immunologyClinical Spectrum of Cutaneous, Ocular, and Hair Manifestations in Patients With Inborn Errors of Immunity: Insights From a Single Center in Turkey.
Immunity, inflammation and diseaseAlopecia Areata - Effects of Treatment with Upadacitinib - Two Case Reports.
Clinical, cosmetic and investigational dermatologyDiagnostic Performance of the Trichogram Compared to Histopathology of Scalp Biopsy in Horizontal Sections in Female Androgenetic Alopecia: A Retrospective Study.
Skin appendage disordersImmune Microenvironment of Hair Follicles in Tumor Immunotherapy.
ImmunoTargets and therapyLate Onset Telomere Biology Disorder Presenting With Pancytopenia, Immune Dysregulation, Interstitial Lung Disease and Alopecia.
American journal of hematologyHerpes Zoster Recurrence With Disease Remission Under JAK Inhibition for Alopecia Areata: Balancing Two Side of Immune Memory.
The Journal of dermatologyRisk for attention deficit hyperactivity disorder in alopecia areata patients: A nationwide case-control study.
Annales de dermatologie et de venereologieEffectiveness of Baricitinib on Nail Alopecia Areata: A 48-Week Single-Center Retrospective Study.
Clinical drug investigationPoly‑D,L‑lactic acid (PDLLA) scalp microinjection protocol with optional light microneedling priming for non‑scarring alopecia: A prospective pilot case series.
JPRAS openExosomes in Skin of Color: Dermatological Insights, Therapeutic Potential, and Clinical Realities in India.
CureusSex-based clinical and immunological differences across lupus erythematosus subtypes: a cross-sectional multicentre study from China.
Lupus science & medicineClinical characteristics, subtype classification, and prognostic factors of ophiasis: A retrospective study of 150 patients with therapeutic implications.
Journal of the American Academy of DermatologyRapunzel Syndrome in a Pediatric Female Patient: A Case Report of Trichobezoar Causing Intestinal Obstruction.
CureusSacituzumab tirumotecan (sac-TMT/MK-2870/SKB264): a novel antibody-drug conjugate in breast cancer.
Oncology reviewsEngineered Exosomes Co-Delivering EGF and FGF Ameliorate Androgenetic Alopecia in a Mouse Model.
International journal of nanomedicineAssociations of Lichen Sclerosus With Autoimmune Diseases: A Systematic Review and Meta-Analysis.
BJOG : an international journal of obstetrics and gynaecologyPathological Insights into the Limitations of Clinical and Dermoscopic Evaluations in Monitoring Sonidegib Treatment Response for Locally Advanced Basal Cell Carcinoma: A Real-World Study.
Dermatology and therapyVisit complexity differs between scarring and nonscarring alopecia: A 5-year DataDerm analysis.
Journal of the American Academy of DermatologyROS-responsive hydrogel-delivered miR-665 targets STAT3 to alleviate inflammation and promote hair follicle regeneration in alopecia areata.
Journal of nanobiotechnology5α-Reductase Isoenzymes: From Neurosteroid Biosynthesis to Neuropsychiatric Outcomes.
NeuroSciLifestyle factors affecting the pathogenesis of androgenetic alopecia: a literature review.
Frontiers in public healthAndrogenetic Alopecia in Women: A Narrative Review of Pathophysiology, Clinical Evaluation, and Treatments.
American journal of clinical dermatologyImpact of GLP-1 and GLP-1/GIP agonists on healthcare resource utilization in individuals with scarring alopecias: A retrospective cohort analysis using TriNetX.
Journal of the American Academy of DermatologyPublisher's Note: British Association of Dermatologists living guideline for managing people with alopecia areata 2024.
The British journal of dermatologyEarly-Onset Trichotillomania With Predominantly Other-Directed Trichophagia in a 23-Month-Old Girl: A CARE-Compliant Case Report.
Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & PractitionersPegylated liposomal doxorubicin plus carboplatin versus paclitaxel plus carboplatin as first-line therapy for epithelial ovarian cancer (CGCS-04): a multicenter, randomized clinical trial.
Therapeutic advances in medical oncologyOral Tofacitinib for Refractory Lichen Planus Pigmentosus Coexisting with Frontal Fibrosing Alopecia.
Indian dermatology online journalThe extract of Cyperus rotundus rhizome promotes hair growth and modulates hair cycle in vivo and in vitro.
Chinese journal of natural medicinesRisk of new-onset hair loss with semaglutide and tirzepatide: A TriNetX cohort study.
Journal of the American Academy of DermatologyTargeting the Gut Microbiota with Pro- and Postbiotics: Emerging Strategies against Alopecia.
Probiotics and antimicrobial proteinsHistological and Trichographic Differences Between Coat Types in Non-Alopecic Pomeranians and With Alopecia X.
Veterinary dermatologyEffect of Platelet-Rich Plasma on Hair Follicle Growth in C57BL/6 Mice.
Aesthetic plastic surgeryCinnamomum burmannii Leaves-Derived Carbon Dots Promote Angiogenesis and Stimulate Hair Follicle Regeneration by Reshaping the Microenvironment of Hair Follicles.
ACS applied materials & interfacesRadiation-Induced Alopecia in Patients Undergoing Intracranial Radiotherapy: A Systematic Review.
International journal of radiation oncology, biology, physicsEXPRESS: Carbon dioxide laser ablation as an alternative or adjunct treatment of Bowenoid in situ carcinoma (BISC) in five cats.
Journal of feline medicine and surgeryThe Economic Burden of Alopecia Areata: Evidence from a Survey in Norway and Sweden.
Acta dermato-venereologicaEpidemiology, Diagnosis and Management of Alopecia Areata: An Asia-Pacific Modified Delphi Expert Panel Recommendations.
International journal of dermatologyJAAD CME Part 2: Clinical Evidence and Safety Considerations for GLP-1 Receptor Agonists in Dermatology.
Journal of the American Academy of DermatologyExpanding the therapeutic landscape of minoxidil for androgenetic alopecia: topical, oral and sublingual formulations.
Frontiers in pharmacologySALT Score Cards: Facilitating SALT Score Calculation in Alopecia Areata.
The Australasian journal of dermatologyElucidating the Role of Vitamin D Receptor (VDR) Polymorphisms in Genetic Susceptibility to Systemic Lupus Erythematosus: A Case-Control Study From Western India.
International journal of immunogeneticsHair follicle-targeted baicalin nanocrystal delivery using microneedles for long-acting treatment of androgenetic alopecia.
International journal of pharmaceuticsManaging Skin Diseases that Flare During Pregnancy and in the Postpartum period: Part 2- Management & Safety Considerations.
Journal of the American Academy of DermatologyVitamins and hair: Sham or science?
Clinics in dermatologyLine-Field Confocal OCT in Primary Cicatricial Alopecias: Enabling Precision Diagnosis and Clinical Decision Support.
International journal of dermatologyArtificial intelligence-enabled precision medicine for inflammatory skin diseases.
The Journal of investigative dermatologyEffective topical delivery of minoxidil via chitosan coated nanocapsules to remodel microenvironment of dermal follicle for hair regeneration.
Drug delivery and translational researchMLPH-mediated activation of dermal papilla IGF-1 signaling drives human hair shaft elongation and anagen induction.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieAlopecia as an atypical presentation of Langerhans cell histiocytosis in an adult male.
JAAD case reportsPostpartum-Onset Dermatomyositis Presenting With Malignant Pleural Effusion: A Case Report.
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Frequency and associated factors of herpes zoster infection in SLE patients from Latin America: data from the GLADEL 2.0 cohort.
- An updated guide to hair follicle stem cell markers and changes in their expression with aging.
- Trusting your gut: a hairy situation-gastric trichobezoar case report.
- Pharmacokinetics and Analgesic Efficacy of a Novel Extended-Release Buprenorphine Formulation in Mice.Journal of the American Association for Laboratory Animal Science : JAALAS· 2026· PMID 41833307mais citado
- Combined itraconazole and terbinafine therapy for pediatric kerion: a report of two cases.
- A Unique Case of Lupus Erythematosus Profundus Presenting With Localized Scarring Alopecia and Perioral Swelling in a Pediatric Patient.
- Dental Rehabilitation of a Child Diagnosed With Alopecia Areata Totalis: A Case Report.
- Skin toxicity induced by chemotherapy or molecular targeted therapy combined with immune checkpoint inhibitors in Asian patients: A literature review by the Japanese Pharmacist-led Oncodermatology Study Team.
- How Long to Treat to Achieve Desired Treatment Outcomes with Baricitinib 4 mg in Severe Alopecia Areata: Evidence-based Approach.
- Time to Maximal Response with Low-Dose Oral Minoxidil in Clinical Treatment of Androgenetic Alopecia.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:79364(Orphanet)
- MONDO:0004907(MONDO)
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q181391(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
