Astrocitoma são tumores (neoplasia) do sistema nervoso central (SNC) originados de um astrócito, uma célula em forma de estrela que sustenta os neurônios. É o tipo de glioma mais comum e podem ser benignos ou malignos. Quanto menor o grau, mais tempo de sobrevida, que pode ultrapassar 10 anos ou serem menor a 1 ano. Afetam 5 em cada 100.000 pessoas.
Introdução
O que você precisa saber de cara
Astrocitoma de baixo grau é um tumor cerebral raro que pode causar sintomas como cefaleia, déficits visuais e hormonais (prolactina elevada, hipopituitarismo, hipogonadismo, hipotireoidismo). Pode afetar a memória e a função sexual, com mutações em genes como BRAF e IDH2.
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 11 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 20 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
8 genes identificados com associação a esta condição.
GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and
CytoplasmCell membraneMitochondrionNucleus
Noonan syndrome 5
A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells.
Plays a role in intermediary metabolism and energy production (PubMed:19228619, PubMed:22416140). It may tightly associate or interact with the pyruvate dehydrogenase complex (PubMed:19228619, PubMed:22416140)
Mitochondrion
D-2-hydroxyglutaric aciduria 2
A neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. Both a mild and a severe phenotype exist. The severe phenotype is homogeneous and is characterized by early infantile-onset epileptic encephalopathy and cardiomyopathy. The mild phenotype has a more variable clinical presentation. Diagnosis is based on the presence of an excess of D-2-hydroxyglutaric acid in the urine.
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621, PubMed:39809765). Plays an important role in the regulation of cell proliferation (PubMed:22711838, PubMed:23698361). Activates MAPK1/MAPK3 resulting in phosphorylation and ultimately degradation of GJA1 (By similarity). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306)
Cell membraneEndomembrane systemCytoplasm, cytosol
Leukemia, acute myelogenous
A subtype of acute leukemia, a cancer of the white blood cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils, eosinophils and monocytes.
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179)
NucleusCytoplasmCell membrane
May play a role in photoreceptor function
MembraneCell projection, cilium
Retinitis pigmentosa 86
A form of retinitis pigmentosa, a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP86 is an autosomal recessive form.
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:15494731, PubM
Cell membraneEndosome membraneEarly endosome membraneCell projection, axonCell projection, dendriteCytoplasm, perinuclear regionPostsynaptic density
Developmental and epileptic encephalopathy 58
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE58 is an autosomal dominant condition characterized by onset of refractory seizures in the first days or months of life.
Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activati
Cell membraneNucleusCytoplasm, cytosolCytoplasmic vesicle
Pfeiffer syndrome
A syndrome characterized by the association of craniosynostosis, broad and deviated thumbs and big toes, and partial syndactyly of the fingers and toes. Three subtypes are known: mild autosomal dominant form (type 1); cloverleaf skull, elbow ankylosis, early death, sporadic (type 2); craniosynostosis, early demise, sporadic (type 3).
Medicamentos e terapias
Mecanismo: Interferon alpha/beta receptor agonist
Mecanismo: DNA topoisomerase II inhibitor
Mecanismo: DNA topoisomerase II alpha inhibitor
Mecanismo: FK506-binding protein 1A inhibitor
Mecanismo: Dual specificity mitogen-activated protein kinase kinase; MEK1/2 inhibitor
Mecanismo: Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
Mecanismo: RAF serine/threonine protein kinase inhibitor
Mecanismo: FK506-binding protein 1A inhibitor
Mecanismo: Epidermal growth factor receptor erbB1 inhibitor
Variantes genéticas (ClinVar)
644 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
87 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Astrocitoma de baixo grau
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
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Outros ensaios clínicos
11 ensaios clínicos encontrados, 3 ativos.
Publicações mais relevantes
Circumscribed low-grade astrocytoma with a synchronous occipital lesion of uncertain pathology in an adolescent with T-cell lymphoblastic lymphoma.
Circumscribed astrocytic glioma, defined by the 2021 WHO Central Nervous System tumour classification, exhibits expansive growth patterns. Despite increasing molecular and histological data, their applicability to adolescents and young adults remains uncertain. Also, the coexistence of T-cell lymphoblastic lymphoma (T-LBL) and circumscribed astrocytic glioma is rare, and no established treatment protocols currently exist.A male in his late teens presented with T-LBL and concurrent intracranial masses in the left paracentral lobule and occipital lobe. Despite achieving a complete response for T-LBL with standard chemotherapy and transplantation, the intracranial lesion (paracentral lobule) progressed. Resection of the paracentral lesion revealed a circumscribed low-grade astrocytoma, not otherwise specified. At 1-year follow-up, without adjuvant therapy, no recurrence was observed and the residual occipital lesion decreased in size.Through interdepartmental collaboration, we achieved a favourable outcome, though the impact of T-LBL treatment on glioma remains unclear. Further studies are needed to establish optimal management for complex cases.
Magnetic resonance imaging findings of dysembryoplastic neuroepithelial tumors and low-grade astrocytomas.
Dysembryoplastic neuroepithelial tumor (DNET) and low-grade astrocytoma (LGA) could present very similar magnetic resonance imaging (MRI) findings. DNET has good seizure control after surgical removal and low malignant potential, while LGA may recur or progress. This study was designed to obtain a more accurate pretreatment diagnosis of DNET and LGA based on MRI findings. We retrospectively enrolled patients with pathologically proven DNET and LGA from 2000 to 2024. Individual qualitative and quantitative MRI features were evaluated in both tumors, especially the T2-weighted signal intensity ratio (T2SR), which compared tumor T2-weighted signal with that of normal cerebral white matter. The diagnostic performance of conventional qualitative models, including meaningful qualitative MRI features and combined quantitative model, including T2SR and apparent diffusion coefficient (ADC) values, was evaluated using area under the curve (AUC). In total, 70 patients (30 DNET, 40 LGA) were included, with a mean age of 23.2 ± 11.3 (15-57) years, including 36 men (51.4%), 34 women (48.6%). For individual MRI features, DNET had more FLAIR (fluid attenuated inversion recovery) ring sign (16 [53.3%] vs 12 [30.0%], p = 0.049), higher ADC value (2076.2 [53.4] vs 1660.1 [71.9], p < 0.001), and higher T2SR (3.56 ± 0.12 vs 2.68 ± 0.63, p < 0.001). The AUC of the T2SR and ADC value was 0.886 (0.811-0.962) and 0.824 (0.724-0.924), respectively. The combined quantitative model had higher discriminative performance than the conventional qualitative model (AUC: 0.905 vs 0.727, p = 0.011). Our study suggested that quantitative MRI features, including T2SR and ADC values, enhanced the discrimination between DNET and LGA and could potentially serve as a complementary imaging marker for improving preoperative diagnostic accuracy.
Spinal deformity following surgery for paediatric intramedullary spinal cord tumours.
Spinal deformity (SD) in children with intramedullary spinal cord tumours (IMSCT) can occur at presentation or postoperatively due to neurogenic and mechanical factors on a background of future spinal growth. Deformity is associated with pain, functional decline and reduced quality of life but spinal instrumentation can compromise MRI tumour surveillance. This study aims to identify risk factors for SD amongst children operated for low-grade IMSCT to identify any modifiable risk factors and help guide pre-operative counselling and surveillance. Cases of benign IMSCT in patients under 16 were identified from a prospectively collected institutional operative database. Review of electronic medical records was then undertaken for details of presenting symptoms, SD at diagnosis, histology, surgical approach (laminectomy/laminoplasty). High grade tumours and previously operated tumours were excluded. Outcome measures comprised spinal alignment at last follow-up and any additional interventions (bracing or surgery) to address deformity. Data was analysed using Excel and SPSS. 45 patients satisfied the inclusion criteria. Mean age at index surgery was 7.1 years, and at last follow up 13.8 years. At presentation, 38% had SD (N = 17/45), 11% torticollis (n = 5/45), 64% pain (n = 30/45) and 43% weakness (n = 19/45). Tumour location was thoracic (40%, n = 18/45)), cervicothoracic (33%, n = 14/45) and cervical (27%, n = 12/45). Tumour histology included low-grade astrocytoma (66%, n = 30/45), glioneuronal tumour (13%, n = 6/45), ependymoma (7%, n = 3/45), cavernoma (4%, n = 2/45), haemangioblastoma (2%, n = 2/45) and neuroenteric cyst (2%, n = 1/45), Laminoplasty was performed in all cases, 51% (n = 23/45) crossing a junctional level. Postoperative MRI confirmed total resection in 51% (n = 23/45). 43% received adjuvant therapy (n = 19/45). 85% (n = 38/45) wore a post-operative spinal orthosis for mean duration 5.27 months (range 1.5-36 months). Postoperative SD occurred in 69% (n = 31/45) of which 48% (n = 15/31) developed following surgery, typically within 2.6 years of follow up. 42% required further bracing (n = 19/45) and 31% underwent spinal fusion (n = 14/45) at an average of 5.5 years post-resection. Patients presenting with SD were significantly more likely to require spinal fusion (p = < 0.01). Thoracic location and the presence of a syrinx were also risk factors for progressive SD. SD is common in children with low-grade IMSCT in children affecting one third at presentation and two thirds post-operatively with one third requiring spinal fusion for deformity correction. Risk factors include: SD at presentation, thoracic cord location and presence of syrinx.
Comparative quantitative proteomics of tumoral and peritumoral tissues for distinguishing human glioblastoma from low-grade astrocytoma.
Glioblastoma multiforme (GBM) and low-grade astrocytoma (LGA) are diffuse gliomas with distinct biological features and prognoses. However, the molecular mechanisms driving their differences are not fully understood. In this study, we performed a multi-dataset analysis integrating in-house quantitative proteomics data with high-quality external datasets to identify GBM-specific proteomic alterations between tumoral and peritumoral tissues relative to LGA. Our analysis revealed more pronounced proteomic differences between intra- and peritumoral tissues in GBM than in LGA. Proteins specifically dysregulated in GBM were predominantly linked to upregulated RNA splicing and spliceosome signaling. Through multi-dataset integration, we identified 73 GBM-specific upregulated proteins enriched in processes such as transcriptional regulation, hypoxia and necrosis, cytoskeleton organization, extracellular matrix remodeling, and immune response. Conversely, the 129 GBM-specific downregulated proteins were mainly involved in tumor suppression, G-protein signaling, calcium signaling, and neuronal gap junctions. Using these signature proteins, we developed a risk model based on CDK2, HDAC1, IGFBP2, SLC6A1, and TNR, which significantly predicted overall survival in glioma patients. This study delineates the proteomic landscape of GBM in comparison to LGA and offers a valuable resource for future mechanistic and clinical investigations. SIGNIFICANCE: Diffuse gliomas are a heterogeneous brain tumor that include both low-grade and high-grade variants, each characterized by distinct morphological and biological features. Glioblastoma multiforme (GBM) is the most common primary high-grade and malignant brain tumor, with a median survival of less than 15 months despite aggressive treatment, including surgery, radiotherapy, and chemotherapy. In contrast, low-grade astrocytoma (LGA) exhibits indolent growth and a less aggressive clinical course, resulting in significantly longer patient survival compared to GBM. The molecular mechanisms underlying the biological differences between LGA and GBM are incompletely understood, and there is an urgent need for new molecular biomarkers to enhance diagnosis and therapeutic options. In this study, we conducted a comprehensive multi-dataset analysis by integrating our in-house quantitative proteomics data with several high-quality external datasets. We analyzed tumor and peritumoral tissue samples from human GBM and LGA, and further identified the GBM-specifically regulated proteomic signatures and signaling pathways, which is crucial for understanding the molecular mechanisms driving the aggressive behavior of GBM and could serve as a foundation for developing novel diagnostic biomarkers and therapeutic targets. Future research should focus on validating these GBM-specific proteins in larger cohorts and exploring their functional roles in GBM progression. Additionally, integrating multi-omics data (e.g., genomics, transcriptomics, and metabolomics) with proteomics could provide a more comprehensive understanding of the molecular mechanisms underlying GBM.
Long-Term Efficacy and Safety of Mammalian Target of Rapamycin Inhibitor Treatment for Subependymal Giant Cell Astrocytoma in Tuberous Sclerosis.
Subependymal giant cell astrocytoma (SEGA) is a low-grade astrocytoma occurring in approximately 5%-20% of persons affected with tuberous sclerosis complex (TSC). Therapy options include surgical resection or medical treatment with mammalian target of rapamycin (mTOR) inhibitors ([mTORis] everolimus or sirolimus) to prevent further growth and neurosurgical interventions due to life-threatening hydrocephalus. Short-term follow-up of mTORi treatment has been described in earlier studies; however, data on long-term efficacy and safety are limited. Patients from SEGA studies at Cincinnati Children's Hospital Medical Center with ongoing care at our center and consented to ongoing retrospective records collection were included in the study. Data was compiled from medical records. Our cohort consisted of 25 patients with TSC. All but one were currently receiving mTORi treatment with either sirolimus (N = 4, 20%) or everolimus (N = 20, 80%) at the time of evaluation. Median mTORi treatment duration was 15.5 years (range: 9.8-16.8 years, interquartile range: 0.9 years). One patient underwent SEGA resection after starting mTORi. None required cerebrospinal fluid diversion. In 19 patients (76%), SEGA was stable or decreased over time. In six patients, it increased slightly from pretreatment baseline. Ongoing adverse drug reactions (ADR) at their last visit were reported in the medical record of eight patients (33%) with intermittent aphthous ulcers being the most frequent (N = 7). Long-term ADRs were observed in 17 patients (68%), including hypercholesterolemia (N = 10), diabetes mellitus type 2 (N = 6), prediabetes (N = 1), hypertension (N = 6), and osteoporosis (N = 3). Long-term TSC-associated SEGA treatment with mTORi is safe, effective and well tolerated. Knowledge of adverse reactions is important for successful long-term therapy.
Publicações recentes
Magnetic resonance imaging findings of dysembryoplastic neuroepithelial tumors and low-grade astrocytomas.
Spinal deformity following surgery for paediatric intramedullary spinal cord tumours.
Circumscribed low-grade astrocytoma with a synchronous occipital lesion of uncertain pathology in an adolescent with T-cell lymphoblastic lymphoma.
Tumefactive Demyelinating Lesion Mimicking Low-Grade Astrocytoma with a T2/FLAIR Mismatch Sign: A Case Report and Review of the Literature.
Added value of sodium MRI in multiparametric MRI for WHO grade II astrocytoma surveillance during "watchful waiting": initial experience.
📚 EuropePMC132 artigos no totalmostrando 158
Magnetic resonance imaging findings of dysembryoplastic neuroepithelial tumors and low-grade astrocytomas.
Journal of the Chinese Medical Association : JCMASpinal deformity following surgery for paediatric intramedullary spinal cord tumours.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryCircumscribed low-grade astrocytoma with a synchronous occipital lesion of uncertain pathology in an adolescent with T-cell lymphoblastic lymphoma.
BMJ case reportsTumefactive Demyelinating Lesion Mimicking Low-Grade Astrocytoma with a T2/FLAIR Mismatch Sign: A Case Report and Review of the Literature.
Diagnostics (Basel, Switzerland)Added value of sodium MRI in multiparametric MRI for WHO grade II astrocytoma surveillance during "watchful waiting": initial experience.
Radiologie (Heidelberg, Germany)Comparative quantitative proteomics of tumoral and peritumoral tissues for distinguishing human glioblastoma from low-grade astrocytoma.
Journal of proteomicsA rare case of posterior fossa collision tumor involving low-grade astrocytoma and meningioma.
Journal of surgical case reportsClinical features and surgical outcomes of pediatric long-level intramedullary spinal cord tumors: a single-institution series of 42 cases.
Neurosurgical reviewLong-Term Efficacy and Safety of Mammalian Target of Rapamycin Inhibitor Treatment for Subependymal Giant Cell Astrocytoma in Tuberous Sclerosis.
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The Pan African medical journalCanine cystic astrocytomas: 7 cases.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, IncPediatric brain tumor classification using deep learning on MR images with age fusion.
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Clinical pathology (Thousand Oaks, Ventura County, Calif.)[Visual fluorescence combined with laser spectroscopy in surgery for intramedullary spinal cord tumors].
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Clinical neurology and neurosurgeryLow-grade astrocytoma in the setting of a developmental venous anomaly.
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Surgical neurology internationalMetabolic remodeling contributes towards an immune-suppressive phenotype in glioblastoma.
Cancer immunology, immunotherapy : CIIRescue bevacizumab following symptomatic pseudoprogression of a tectal glioma post-radiotherapy: a case report and review of the literature.
Journal of neuro-oncologyBCR-NTRK2 fusion in a low-grade glioma with distinctive morphology and unexpected aggressive behavior.
Cold Spring Harbor molecular case studiesReliability of Imaging-Based Diagnosis of Lateral Ventricular Masses in Children.
World neurosurgeryImmunohistochemical Evaluation of Hemostatic Changes in Glioblastoma Multiforme and Low-Grade Astrocytoma.
Turkish neurosurgeryTrajectories of psychosocial and cognitive functioning in pediatric patients with brain tumors treated with radiation therapy.
Neuro-oncologyClinical characteristics, long-term complications and health-related quality of life (HRQoL) in children and young adults treated for low-grade astrocytoma in the posterior fossa in childhood.
Journal of neuro-oncologyExpression of activating transcription factor 5 (ATF5) is increased in astrocytomas of different WHO grades and correlates with survival of glioblastoma patients.
OncoTargets and therapyNeuroglial Differentiation and Neoplasms in Testicular Germ Cell Tumors Lack Immunohistochemical Evidence of Alterations Characteristic of Their CNS Counterparts: A Study of 13 Cases.
The American journal of surgical pathologyPrognostic factors and survival in low grade gliomas of the spinal cord: A population-based analysis from 2006 to 2012.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaIntegrative cross-platform analyses identify enhanced heterotrophy as a metabolic hallmark in glioblastoma.
Neuro-oncologySeizure characteristics are related to tumor pathology in children with brain tumors.
Epilepsy researchDifferential Diagnosis between Low-Grade and High-Grade Astrocytoma Using System A Amino Acid Transport PET Imaging with C-11-MeAIB: A Comparison Study with C-11-Methionine PET Imaging.
Contrast media & molecular imagingProfound hearing loss following surgery in pediatric patients with posterior fossa low-grade glioma.
Neuro-oncology practiceGlioma-related seizures in relation to histopathological subtypes: a report from the glioma international case-control study.
Journal of neurologyAbnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.
Neuroscience lettersSubventricular zone predicts high velocity of tumor expansion and poor clinical outcome in patients with low grade astrocytoma.
Clinical neurology and neurosurgeryA low-grade astrocytoma in a sixteen-year-old boy with a 7q11.22 deletion.
Clinical case reportsDifferentiation of High-Grade from Low-Grade Astrocytoma: Improvement in Diagnostic Accuracy and Reliability of Pharmacokinetic Parameters from DCE MR Imaging by Using Arterial Input Functions Obtained from DSC MR Imaging.
RadiologyDiagnostic Performance of Arterial Spin Labeling for Grading Nonenhancing Astrocytic Tumors.
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in MedicineNovel strategies of Raman imaging for brain tumor research.
OncotargetLow-Grade Astrocytoma within a Mature Cystic Teratoma in an Adolescent Patient.
Journal of pediatric and adolescent gynecologyLow-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2.
Cell reportsIDH1 R132H Mutation Is Accompanied with Malignant Progression of Paired Primary-Recurrent Astrocytic Tumours.
Journal of CancerWhole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature.
OncotargetPresentation and symptom interval in children with central nervous system tumors. A single-center experience.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery[Pediatric brain tumors].
Der RadiologeClinicopathological and imaging features of lipoastrocytoma: Case report.
The neuroradiology journalGene Expression Profiling of Chemokines and Their Receptors in Low and High Grade Astrocytoma.
Asian Pacific journal of cancer prevention : APJCPEndoscopic Treatment of an Adult with Tegmental Astrocytoma Accompanied by Cerebrospinal Fluid Dissemination.
Journal of Korean Neurosurgical SocietySegmentum: a tool for copy number analysis of cancer genomes.
BMC bioinformaticsLabel-free quantitative proteomics unravels the importance of RNA processing in glioma malignancy.
NeuroscienceLow grade astrocytoma causing dural and calvarial destruction.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaTumor Grade versus Expression of Invasion-Related Molecules in Astrocytoma.
Pathology oncology research : POREndoscopic Reconstruction of CSF Pathways in Ventricular Tumors.
Acta neurochirurgica. SupplementA brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas.
Neuro-oncologySimultaneous 11C-Methionine Positron Emission Tomography/Magnetic Resonance Imaging of Suspected Primary Brain Tumors.
PloS onePerinatal (fetal and neonatal) astrocytoma: a review.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryComprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease.
Journal of neuro-oncologyIntraoperative Near-Infrared Optical Imaging Can Localize Gadolinium-Enhancing Gliomas During Surgery.
NeurosurgeryDifferentially Expressed Long Non-Coding RNAs Were Predicted to Be Involved in the Control of Signaling Pathways in Pediatric Astrocytoma.
Molecular neurobiologymiRNA regulation of Sirtuin-1 expression in human astrocytoma.
Oncology lettersIs Upregulation of Aquaporin 4-M1 Isoform Responsible for the Loss of Typical Orthogonal Arrays of Particles in Astrocytomas?
International journal of molecular sciencesRapid malignant transformation of low-grade astrocytoma in a pregnant woman.
The journal of obstetrics and gynaecology researchPrognostic value of the extent of resection in supratentorial WHO grade II astrocytomas stratified for IDH1 mutation status: a single-center volumetric analysis.
Journal of neuro-oncologyConcurrent TERT promoter and BRAF V600E mutation in epithelioid glioblastoma and concomitant low-grade astrocytoma.
Neuropathology : official journal of the Japanese Society of NeuropathologyIDH1 Mutation in Gliomas in Mosul City - Iraq.
Open access Macedonian journal of medical sciencesImaging of Brain Tumors with Copper-64 Chloride: Early Experience and Results.
Cancer biotherapy & radiopharmaceuticalsClinical characteristics and late effects in CNS tumours of childhood: Do not forget long term follow-up of the low grade tumours.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology SocietyPrognostic Value of ALDH1, EZH2 and Ki-67 in Astrocytic Gliomas.
Turk patoloji dergisiA retrospective observational study on the treatment outcomes of 26 patients with spinal cord astrocytoma including two cases of malignant transformation.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research SocietyComparison of cancer survival trends in the United States of adolescents and young adults with those in children and older adults.
CancerHemorrhagic presentations of cerebellar pilocytic astrocytomas in children resulting in death: report of 2 cases.
Journal of neurosurgery. PediatricsNuclear phosphorylated Y142 β-catenin accumulates in astrocytomas and glioblastomas and regulates cell invasion.
Cell cycle (Georgetown, Tex.)Concurrence of Fahr's disease and brain tumor: A case report and review of the literature.
Experimental and therapeutic medicineThe visuospatial functions in children after cerebellar low-grade astrocytoma surgery: A contribution to the pediatric neuropsychology of the cerebellum.
Journal of neuropsychologyInhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis.
Nature communicationsManganese superoxide dismutase (MnSOD) is a malignant astrocytoma specific biomarker and associated with adverse prognosis in p53 expressing glioblastoma.
Pathology, research and practiceA case report on 1-year follow-up of bilateral thalamic glioma.
The neuroradiology journalCongenital glioneuronal tumor with neuropil-like islands.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaA case of an epithelioid glioblastoma with the BRAF V600E mutation colocalized with BRAF intact low-grade diffuse astrocytoma.
Neuropathology : official journal of the Japanese Society of NeuropathologySurgical approaches for brainstem tumors in pediatric patients.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryAnaplastic astrocytoma mimicking herpes simplex encephalitis in 13-year old girl.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology SocietyDifferentiation between Solitary Cerebral Metastasis and Astrocytoma on the Basis of Subventricular Zone Involvement on Magnetic Resonance Imaging.
PloS oneEffects of Insula Resection on Autonomic Nervous System Activity.
Journal of neurosurgical anesthesiologyGamma Knife treatment of low-grade gliomas in children.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryEndoscopic diagnosis of an MRI-occult, low-grade glioma with ependymal dissemination.
Journal of neurosurgery. PediatricsQuantitative proteomic analysis shows differentially expressed HSPB1 in glioblastoma as a discriminating short from long survival factor and NOVA1 as a differentiation factor between low-grade astrocytoma and oligodendroglioma.
BMC cancerAstrocytic tumour grading: a comparative study of three-dimensional pseudocontinuous arterial spin labelling, dynamic susceptibility contrast-enhanced perfusion-weighted imaging, and diffusion-weighted imaging.
European radiologyIncidentalomas to glioblastoma multiforme.
Oxford medical case reportsLow grade astrocytoma in children under the age of three years: a report from the Canadian pediatric brain tumour consortium.
Journal of neuro-oncologyMachine learning methods for the classification of gliomas: Initial results using features extracted from MR spectroscopy.
The neuroradiology journalCentral nervous system tumors: Radiologic pathologic correlation and diagnostic approach.
Journal of neurosciences in rural practiceAnaplastic ganglioglioma: a report of three cases and review of the literature.
Journal of neuro-oncologyEvaluation of amygdala pathology using (11)C-methionine positron emission tomography/computed tomography in patients with temporal lobe epilepsy and amygdala enlargement.
Epilepsy researchGrowth-factor-driven rescue to receptor tyrosine kinase (RTK) inhibitors through Akt and Erk phosphorylation in pediatric low grade astrocytoma and ependymoma.
PloS oneBiopsy of Brainstem Gliomas Using Flexible Endoscopes.
Journal of neurological surgery. Part A, Central European neurosurgeryNon-Hodgkin lymphoma in pediatric patients with common variable immunodeficiency.
European journal of pediatricsHolocord low grade astrocytoma--Role of radical irradiation and chemotherapy.
Journal of the Egyptian National Cancer InstituteNotch signaling activation in pediatric low-grade astrocytoma.
Journal of neuropathology and experimental neurologycAMP-Epac Pathway Stimulation Modulate Connexin-43 and MicroRNA-21 Expression in Glioma Cells.
Basic and clinical neuroscienceAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Circumscribed low-grade astrocytoma with a synchronous occipital lesion of uncertain pathology in an adolescent with T-cell lymphoblastic lymphoma.
- Magnetic resonance imaging findings of dysembryoplastic neuroepithelial tumors and low-grade astrocytomas.
- Spinal deformity following surgery for paediatric intramedullary spinal cord tumours.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery· 2026· PMID 41546829mais citado
- Comparative quantitative proteomics of tumoral and peritumoral tissues for distinguishing human glioblastoma from low-grade astrocytoma.
- Long-Term Efficacy and Safety of Mammalian Target of Rapamycin Inhibitor Treatment for Subependymal Giant Cell Astrocytoma in Tuberous Sclerosis.
- Tumefactive Demyelinating Lesion Mimicking Low-Grade Astrocytoma with a T2/FLAIR Mismatch Sign: A Case Report and Review of the Literature.
- Added value of sodium MRI in multiparametric MRI for WHO grade II astrocytoma surveillance during "watchful waiting": initial experience.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:251592(Orphanet)
- MONDO:0016685(MONDO)
- GARD:20706(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q55786374(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
