Raras
Buscar doenças, sintomas, genes...
Fenda palato mole e duro
ORPHA:664372CID-10 · Q35.5DOENÇA RARA

O palato é o teto da boca dos animais vertebrados, incluindo os humanos. Ele separa a cavidade oral da cavidade nasal. O palato é dividido em duas partes, a parte óssea anterior e a parte mole posterior.

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Introdução

O que você precisa saber de cara

📋

A fenda palatina, afetando o palato mole e duro, é uma anomalia congênita que pode levar à hipoplasia maxilar, fala hipernasal, micrognatia e má oclusão dentária.

🏥
SUS: Cobertura mínimaScore: 15%
CID-10: Q35.5
🇧🇷Dados SUS / DATASUS
PROCEDIMENTOS SIGTAP (5)
0202010503
Cariótipo — bandas G, Q ou Rgenetic_test
0202010600
Pesquisa de microdeleções/microduplicações por FISHlab_test
0202010694
Sequenciamento completo do exoma (WES)rehabilitation
0202010260
Dosagem de alfa-fetoproteína
0301070040
Atendimento em reabilitação — doenças raras
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

😀
Face
3 sintomas
🦷
Dentes
1 sintomas

Características mais comuns

55%prev.
Má oclusão dentária
Frequente (79-30%)
55%prev.
Fala hipernasal
Frequente (79-30%)
55%prev.
Hipoplasia da maxila
Frequente (79-30%)
17%prev.
Micrognatia
Ocasional (29-5%)
4sintomas
Frequente (3)
Ocasional (1)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 4 características clínicas mais associadas, ordenadas por frequência.

Má oclusão dentáriaDental malocclusion
Frequente (79-30%)55%
Fala hipernasalHypernasal speech
Frequente (79-30%)55%
Hipoplasia da maxilaHypoplasia of the maxilla
Frequente (79-30%)55%
MicrognatiaMicrognathia
Ocasional (29-5%)17%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa7
Últimos 10 anos200publicações
Pico202341 papers
Linha do tempo
20202019Hoje · 2026🧪 2006Primeiro ensaio clínico📈 2023Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
·Pré-clínico2
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 2 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Fenda palato mole e duro

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Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

0 ensaios clínicos encontrados.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

🥉Melhor nível de evidência: Relato de caso
Timeline de publicações
0 papers (10 anos)
#1

Orofacial clefting in PHF6-related Börjeson-Forssman-Lehmann syndrome.

BMJ case reports2026 Feb 25

Börjeson-Forssman-Lehmann syndrome (BFLS) is a rare X-linked neurodevelopmental disorder caused by pathogenic variants in the plant homeodomain finger protein 6 (PHF6) gene. Core features include developmental delay, intellectual disability, dysmorphic craniofacial characteristics, obesity, hypogonadism and digital anomalies. Orofacial clefting has not been recognised as part of the canonical phenotype and is rarely reported in association with BFLS. One cohort study listed cleft lip and/or palate as an uncommon feature without individual case details, and a separate report described a female with a nonsense PHF6 variant and clefting of the hard and soft palate. Here, we describe a BFLS female with a de novo missense PHF6 variant who presented with cleft palate. This case adds to the emerging evidence that clefting, though uncommon, may be a recurrent manifestation. It supports the inclusion of PHF6 in the genetic testing of patients presenting with syndromic orofacial clefting when accompanied by neurodevelopmental delay or dysmorphism.

#2

Design of Buccinator Flaps for Oronasal Fistula Repair: A Technical Review and Case Series.

Eplasty2026

Oronasal fistula (ONF) repair remains a significant challenge in patients with cleft lip and palate, particularly when local palatal tissue is insufficient. Regional flaps, including the buccal myomucosal flap (BMMF) and the facial artery musculomucosal (FAMM) flap, offer reliable reconstructive options. This study reviews the surgical anatomy, design, and clinical outcomes of these buccinator-based flaps in ONF repair. This retrospective case series included 13 patients who underwent ONF repair using a BMMF or a FAMM flap between 2017 and 2024. Patient demographics, fistula characteristics, surgical details, postoperative care, and outcomes were collected and analyzed. Six patients underwent BMMF reconstruction, while 7 received FAMM flaps. Successful fistula closure was achieved in 66.7% of patients in the BMMF group, with flap dehiscence occurring in 2 cases, both associated with digital manipulation. The FAMM flap cohort had a 100% fistula closure rate but exhibited a high incidence (86%) of postoperative scar contracture, with 4 patients requiring contracture release. Based on this experience, the authors propose an algorithm for flap selection in ONF repair. Posteriorly based BMMFs are well suited for fistulas at the junction of the hard and soft palate (Type III) and the posterior third of the hard palate (Type IV). Superiorly based FAMM flaps are preferred for anterior ONFs, particularly those extending into the alveolus. The central hard palate remains a reconstructive challenge, with FAMM flaps offering better reach, though they require staged inset and debulking. Both BMMF and FAMM flaps provide vascularized tissue for ONF closure with minimal donor site morbidity. Strategic flap selection based on fistula location optimizes outcomes while mitigating complications.

#3

Minor modification of soft palate surgical technique resulted in a considerable increase of residual cleft dimensions for unilateral cleft lip and palate.

Journal of plastic surgery and hand surgery2026 Feb 04

A two-stage surgical approach, starting with the soft palate, has been practiced in the Gothenburg cleft team for unilateral cleft lip and palate (UCLP) since decades. To improve the velopharyngeal function, a modified soft palate closure (SPC) technique was introduced. Clinical observations did however indicate that the novel technique resulted in a deviant residual cleft shape, potentially contributing to future compromised dental arch form. This study aimed to compare residual cleft dimensions (area, width and length) between different SPC techniques and at various age, in individuals born with UCLP.  Material and methods: The sample consisted of three groups of children with non-syndromic UCLP:  1. 27 individuals who had original SPC and hard palate closure (HPC) at 3 years (GBG3) 2. 37 individuals who had a modified SPC and HPC at 2 years (GBGmod)  3. 29 individuals who had original SPC and HPC at 2 years (GBG2).  Residual cleft area, length and width were measured on digitised cast models using Blender software. Multiple linear regression analysis was used to compare the groups. Larger residual cleft dimensions (area and length) were found for GBGmod compared to both GBG3 (p < 0.001, p = 0.009) and GBG2 (p = 0.009, p = 0.009). In addition, GBGmod had increased cleft width in comparison with GBG3 and GBG2 in quartile 1. The modified SPC technique resulted in larger residual clefts in comparison with the groups operated with the original SPC method. Timing differences between GBG3 and GBG2 are likely one explanation of cleft width variations anteriorly.

#4

Doble Aligner Nasoalveolar Molding: A New Approach of Digital Protocol for Cleft Lip and Palate in Newborn Patients.

International journal of clinical pediatric dentistry2026 Jan

In Spain, a new digital workflow protocol has been developed for patients with cleft lip and palate. This protocol involves several steps, including the creation of a double aligner tray for nasoalveolar molding (2A-NAM) and the utilization of digital intraoral scans for the movement design. The sequential process includes: intraoral scanning (IOS), virtual design (VD), digital impression (DI), 2A-NAM preparation, and analysis of anatomical changes. This process is repeated until the desired outcomes are achieved. At just 7 days of age, records of the male child were obtained using an iTero® Element 5D intraoral laser scanner. Additionally, an extraoral record was taken to measure the distance from the commissure to the left nostril, which enables the reconstruction of the nasal stent of the tray. The resulting stereolithography (STL) files underwent digital planification using 3D NemoStudio. The degree of approximation, rotation, and inclination of major and minor segments varied for each (M) based on each individual record and the patient's specific condition. Finally, the Form 3+® 3D-printer was used to produce the VD using Formlabs® photopolymer resin. The technician then assembled the device using a Durasoft® PD splint (both hard and soft components), to which tension springs were added using wire and secured with resin. A total of five 2A-NAMs were required to achieve proper segment approximation prior to orthopedic surgery at 4.5 months of age. By assessing the anatomical predictions provided by digital simulation, clinicians can make proper decisions regarding the approximation of the maxillary segments of the patient. The predictability of planned approximation movements and the absence of aligner injuries motivate the promotion of the protocol as a reliable method that facilitates pediatric dentistry and orthodontic treatment for any professional, ensuring patient safety. Rico-Lillo I, García-García VJ, Kasem K, et al. Doble Aligner Nasoalveolar Molding: A New Approach of Digital Protocol for Cleft Lip and Palate in Newborn Patients. Int J Clin Pediatr Dent 2026;19(1):110-119.

#5

Comparative analysis of soft tissue response after orthognathic surgery in patients with and without cleft using 3D imaging: A preliminary study.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery2026 Mar

This study investigated differences in upper lip soft tissue response to skeletal movement between patients with and without cleft following orthognathic surgery. Twelve patients with Class III dentofacial deformities underwent orthognathic surgery: six with complete unilateral cleft lip and palate and six age- and sex-matched non-cleft controls. Hard tissue movement was measured using 3D surgical simulation, and soft tissue changes were assessed with 3D photogrammetry. The cleft group showed significantly greater advancement across all hard tissue landmarks compared to the non-cleft group (p < 0.01). However, soft tissue advancement at the subnasale was only moderately greater in the cleft group (p < 0.05), with no significant differences observed at other midline points. Soft-to-hard tissue movement ratios were consistently lower in the cleft group, although these differences did not reach statistical significance. The ratio of soft tissue volume change to A-point displacement was higher in the non-cleft group than in the cleft group (p < 0.05), indicating a reduced soft tissue response in the cleft group. These findings suggest that patients with cleft may require greater skeletal advancement to achieve favorable soft tissue outcomes, highlighting the importance of individualized surgical planning to balance aesthetic goals with complications such as velopharyngeal insufficiency.

Publicações recentes

Ver todas no PubMed

📚 EuropePMCmostrando 199

2026

Design of Buccinator Flaps for Oronasal Fistula Repair: A Technical Review and Case Series.

Eplasty
2026

Orofacial clefting in PHF6-related Börjeson-Forssman-Lehmann syndrome.

BMJ case reports
2026

Minor modification of soft palate surgical technique resulted in a considerable increase of residual cleft dimensions for unilateral cleft lip and palate.

Journal of plastic surgery and hand surgery
2026

Doble Aligner Nasoalveolar Molding: A New Approach of Digital Protocol for Cleft Lip and Palate in Newborn Patients.

International journal of clinical pediatric dentistry
2025

Cleft Lip and Palate: Overview of Causes, Surgical Repair, and Treatment Approaches: A Narrative Review.

World journal of plastic surgery
2026

Comparative analysis of soft tissue response after orthognathic surgery in patients with and without cleft using 3D imaging: A preliminary study.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
2026

3D-Printed Models in Oral Surgery Simulation Training: A Scoping Review.

Journal of dental education
2026

Surgical treatment of 89 patients with craniofacial microsomia in a craniofacial national reference centre in Finland.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
2025

Speech Results in 10-Year-Old Children With Isolated Cleft Palate.

The Journal of craniofacial surgery
2025

Nine Years, 293 Cases: Advancing Wide Cleft Palate Repair: Insights, Techniques, and Outcomes From Cleft Lip and Palate Association of Pakistan's Institutional Experience.

Annals of plastic surgery
2025

Speech Outcomes in 5-Year-Olds Born With Cleft Palate With and Without Robin Sequence-A Swedish Registry Study.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2025

Uncovering the Genetic Architecture of NSCPO in Chinese via Subtype GWAS.

Journal of dental research
2025

Custom subperiosteal implants used to rehabilitate the atrophic edentulous maxilla following multiple failures of both conventional as well as zygomatic implants: a case report.

Journal of surgical case reports
2024

The accuracy of digital scanners versus conventional impression in patients with cleft lip and palate: A cross-sectional study.

The Saudi dental journal
2025

[The features and clinical applications of the buccal fat pad in patients with cleft palate].

Stomatologiia
2025

Evaluation of Surgical Protocols for Speech Improvement in Children with Cleft Palate: A Systematic Review and Case Series.

Bioengineering (Basel, Switzerland)
2025

[A retrospective study on clinical outcomes of implant-supported rehabilitations in patients with alveolar cleft].

Shanghai kou qiang yi xue = Shanghai journal of stomatology
2025

The posterior velar apex defined and its importance in the assessment of velopharyngeal dysfunction. An update of the surface anatomy of the hard and soft palate.

The British journal of oral &amp; maxillofacial surgery
2025

Application of four-section approach for prenatal diagnosis of Pierre robin sequence.

Journal of medical ultrasonics (2001)
2025

Management of Congenital Palatal Fistula Associated With Wiskott-Aldrich Syndrome.

Cureus
2026

Surgical Anatomy of Cleft Palate: A 3-Dimensional Computer Model.

Plastic and reconstructive surgery
2025

Bilateral Islanded Propeller Mucoperiosteal Flap Closure: A New Approach to Wide Cleft Palates.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Evaluation of Velopharyngeal Morphology and Surgical Recovery in Cleft Palate Patients with Different Types of Velopharyngeal Function.

Plastic and reconstructive surgery
2025

Comparative Analysis of Soft and Hard Tissue Outcomes Following Nasoalveolar Molding in Unilateral and Bilateral Cleft Lip and Palate: A Systematic Review.

The Journal of craniofacial surgery
2025

[Dental esthetic restoration for cleft lip and palate patients].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
2025

The efficacy of velar adhesion in unilateral cleft lip and palate patients: Cleft width and otitis media with effusion.

PloS one
2025

Early Assessment after Cleft Palate Repair: Comparative Study between Furlow's and Rotational Flap Techniques.

Journal of Indian Association of Pediatric Surgeons
2025

CLAPP Classification Scheme and Treatment Algorithm for Submucous Cleft Palate.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2025

How Cleft Type and Width Affect the Rate of Secondary Palatal Surgery and Articulation Proficiency in 5-Year-Olds With Cleft Palate.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2025

Does the Surgical Protocol Impact the Burden of Care of Patients With Cleft Lip and/or Palate?

The Journal of craniofacial surgery
2025

Food Texture Preference and Oral Clefts: A New Perspective from a Case-Control Study.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2025

Comparing the Efficacy of Tisseel versus Surgicel as a Hemostatic Agent in Cleft Palate Surgery: A Randomized Controlled Trial.

Journal of maxillofacial and oral surgery
2024

Assessment of Soft Tissue Changes after Various Orthognathic Surgeries for Class III Correction of Cleft Lip and Cleft Palate Patients: A Systematic Review and Meta-Analysis.

Journal of pharmacy &amp; bioallied sciences
2026

Design, Development, and Evaluation of a 3D-Printed Buccal Myomucosal Flap Simulator.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2025

Understanding Access to Care: Factors Influencing Patient Attendance at Craniofacial Speech Evaluations.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2025

Back to the Bottle: Comparison of Palatoplasty Outcomes Before and After Systematic Changes to Postoperative Precaution Protocols.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Recognizing Variations in Primary Palatoplasty Billing: A Review of 9827 Cases.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Speech Outcomes in Children with Robin Sequence Treated with a Pre-Epiglottic Baton Plate.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2024

Cleft Lip and Palate Correction: The Utah Protocol.

Plastic and reconstructive surgery. Global open
2025

Speech Aid Prostheses For Patients With Cleft and Other Craniofacial Birth Conditions.

The Journal of craniofacial surgery
2025

Evaluation of Palatal Bone Regeneration in Cleft Palate Patients after a 2-Stage Palatoplasty Using a Modified Furlow Procedure.

Plastic and reconstructive surgery
2026

A Novel Self-Retentive Obturator to Facilitate Feeding in an Infant with Cleft Palate: A Case Report and Literature Review.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2024

Presurgical Nasoalveolar Molding and Columella Lengthening for Early Unilateral Cleft Lip and Palate Rehabilitation: A Comprehensive Clinical Case Report.

International journal of clinical pediatric dentistry
2025

Different Surgical Approaches to the Treatment of Cleft Palate Fistulae as Perceived by Cleft Surgeons.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2025

Radical Overlapping Intravelar Veloplasty during Primary Cleft Palate Repair Results in Decreased Secondary Speech Surgery.

Plastic and reconstructive surgery
2024

The state of systemic immunity in congenital cleft lip and palate patients with diseases of oral cavity tissues.

Wiadomosci lekarskie (Warsaw, Poland : 1960)
2024

Clinical outcomes of gingivoperiosteoplasty for unilateral cleft lip and palate performed in early childhood.

Journal of plastic, reconstructive &amp; aesthetic surgery : JPRAS
2024

An effective ultrasound fetal palate screening software based on the "sequential sector scan through the oral fissure" and three-dimensional ultrasound.

BMC pregnancy and childbirth
2024

Condition of oral tissues in children with congenital cleft lip and palate.

Wiadomosci lekarskie (Warsaw, Poland : 1960)
2025

Rehabilitation of Combined Hard and Soft Palate Defects with a Soft Relining Prosthesis: A Clinical Report.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2024

Change in Lower Lip Position After Le Fort I Advancement in Patients with Bilateral vs. Unilateral Cleft Lip and Palate.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2024

Comparison of Soft Tissue Chin Thickness in Adult Patients With Various Mandibular Divergence Patterns.

Cureus
2024

Three-Dimensional Cone Beam Computed Tomography (CBCT)-Derived Soft Tissue Changes in Patients with Unilateral Cleft Lip, Alveolus, and Palate with Midfacial Deficiency after 1.5 Years of Bone-Anchored Maxillary Protraction.

Journal of clinical medicine
2025

Medially Positioned Single Mucoperiosteal Flap With and Without Allograft Membrane for Repair of Congenital Cleft Palate in 4 Dogs.

Journal of veterinary dentistry
2024

Is the collateral circulation pattern in the hard palate affected by cleft deformity?

Clinical oral investigations
2024

Prenatal Ultrasound Imaging of Orofacial Clefts: A Pictorial Essay.

Journal of medical ultrasound
2024

Hollow Complete Denture With a Speech Bulb Prosthesis: A Case Report.

Cureus
2024

Mature Cystic Oral Teratoma in a Neonate- A Case Report.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
2024

Three-dimensional finite element analysis on stress distribution after different palatoplasty and levator veli palatini muscle reconstruction.

Clinical oral investigations
2024

Two-stage palatal repair in non-syndromic CLP patients using anterior to posterior closure is associated with minimal need for secondary palatal surgery.

Head &amp; face medicine
2024

Three-dimensional Measurement of the Zygomatic-maxillary Complex in the Class III Malocclusion Patients with Maxillary Retrusion.

The Journal of craniofacial surgery
2024

The accuracy and retention of presurgical infant orthopaedics constructed from different polymer materials: A comparative study.

Journal of Taibah University Medical Sciences
2023

Management of a Rare Tessier 30 Median Mandibular Cleft Anomaly: A Comprehensive Review.

International journal of clinical pediatric dentistry
2023

Rehabilitation of a Patient with Cleft Palate Using a Hollow Lightweight Fixed Prosthesis.

Contemporary clinical dentistry
2024

[Modern management of children with cleft lip and palate].

Orvosi hetilap
2023

Impact of relaxing incisions on maxillofacial growth following Sommerlad-Furlow modified technique in patients with isolated cleft palate: a preliminary comparative study.

BMC surgery
2023

A comparison of maxillofacial growth in Chinese children with isolated cleft palate treated with two different palatoplasty techniques without relaxing incisions: a preliminary study.

BMC oral health
2025

Buccal Fat Pad in Primary and Secondary Cleft Palate Repair: A Systematic Review of the Literature.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2024

Three-dimensional nasal asymmetry analysis between adolescence and adulthood in postoperative patients with unilateral cleft lip and palate using computed tomography.

Odontology
2023

Primary or metastatic branchial cleft carcinoma?: a case report.

Frontiers in surgery
2023

Tissue adjuncts in primary cleft palate reconstruction: A systematic review.

Journal of plastic, reconstructive &amp; aesthetic surgery : JPRAS
2025

Remote Real-Time Training for Sustainable Cleft Operation in Rural Region of West Africa: Effective Webinar in the COVID-19 Pandemic.

The Journal of craniofacial surgery
2023

Presurgical Orthopedic Nasoalveolar Molding in Cleft Lip and Cleft Palate: Case Report.

International journal of clinical pediatric dentistry
2023

Trio-based GWAS identifies novel associations and subtype-specific risk factors for cleft palate.

HGG advances
2024

Three-dimensional Anatomy of the Velopharyngeal Muscles in the Cleft Palate.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2023

Classification of Skeletal Phenotypes of Preadolescent Patients With Isolated Cleft Palate Using Principal Component Analysis and Cluster Analysis.

The Journal of craniofacial surgery
2025

Dermoid Cyst of the Hard Palate: Case Report and Review of the Literature.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2023

Speech Outcomes Audit for Unilateral Cleft lip and Palate After 2-Stage Palate Repair: Preliminary Results.

The Journal of craniofacial surgery
2023

Pilot study: Correlation between nasalance scores and cephalometric parameters in Estonian cleft palate children.

Stomatologija
2023

An introduction to the UK care pathway for children born with a cleft of the lip and/or palate.

British dental journal
2023

The role of primary surgery in the management of orofacial clefting.

British dental journal
2023

Long-term longitudinal follow-up of individuals with UCLP after Gothenburg twostage palate closure: surgical and speech outcomes.

Journal of plastic surgery and hand surgery
2023

Maxillary anterior segmental distraction osteogenesis to correct maxillary hypoplasia and dental crowding in cleft palate patients: a preliminary study.

BMC oral health
2023

Effect of Pre-Surgical Orthopedic Treatment on Hard and Soft Tissue Morphology in Infants with Cleft Lip and Palate.

Diagnostics (Basel, Switzerland)
2023

Sommerlad-Furlow modified palatoplasty: A retrospective study.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
2023

Pronator quadratus musculo-osseous free flap for wide hard palatal defect reconstruction: An anatomical study.

Journal of plastic, reconstructive &amp; aesthetic surgery : JPRAS
2024

Prediction of Early Postoperative Pain in Infants Undergoing Primary Cleft Palate Repair.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2023

Surgical Assistance for Favorable Outcome Achieved through Presurgical Nasoalveolar Molding Using Innovative Impression Technique: A Case Report.

International journal of clinical pediatric dentistry
2023

A Neonatal Patient Diagnosed with Chromosome 18p 11.1 Microdeletion Syndrome Presented with Trisomy 18Like Phenotype.

Case reports in pediatrics
2023

Understanding the distinction between cleft lip and cleft palate: a critical step for successful prenatal detection.

Current opinion in obstetrics &amp; gynecology
2023

Functional cleft palate surgery.

Journal of oral biology and craniofacial research
2023

Surgical closure of cleft palate defects in dogs using a modification of the traditional von Langenbeck technique: 12 cases (2015-2022).

Journal of the American Veterinary Medical Association
2023

Evaluation of Postoperative Outcomes in Two Cleft Palate Repair Techniques without Relaxing Incisions.

Plastic and reconstructive surgery
2023

HOW PRO'S CAN CONTRIBUTE TO WHAT MATTERS MOST TO PATIENTS WITH OROFACIAL CLEFTS.

The journal of evidence-based dental practice
2022

Reverse Facial-Submental Artery Osteomyocutaneous Flap, a Novel Choice for Previously Operated Huge Alveolar Clefts.

World journal of plastic surgery
2022

Comparison of velopharyngeal morphology of two palatoplasty techniques in patients with hard and soft cleft palate.

Frontiers in surgery
2023

Cleft Palate Syndrome in the Endangered Spectacled Flying Fox (Pteropus conspicillatus): Implications for Conservation and Comparative Research.

Veterinary sciences
2024

Effect of Acellular Dermal Matrix on Long-Term Speech Outcomes in Primary Palatoplasty with Radical Intravelar Veloplasty.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2023

The Utility of the Ultrasound "Superimposed-Line" Sign at the Junction of the Vomer and Maxilla in First-Trimester Screening for Fetal Cleft Palate: A Case-Control Study.

Fetal diagnosis and therapy
2023

Long-term Outcome for Two-Stage Palatal Closure With Different Timings for Hard Palate Surgery: Craniofacial Growth and Dental Arch Relation.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2024

Predictors of Adverse Outcomes Following Cleft Palate Repair: An Analysis of Over 2500 Patients Using International Smile Train Data.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2024

Unraveling a Major Burden of Orofacial Clefts Analyses: Classification of Cleft Palate Fistulas by Cleft Surgeons.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2024

Repeat Buccal Flaps Successfully Reduce Hypernasality in a Patient with Cleft Palate.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2023

Scandcleft randomized trials of primary surgery for unilateral cleft lip and palate: Speech proficiency at 10 years of age.

International journal of language &amp; communication disorders
2023

Treacher Collins syndrome - a case report.

Case reports in perinatal medicine
2023

Maxillary arch dimensions, occlusion assessment and space conditions in patients with cleft palate in the period of deciduous dentition-A retrospective study.

Journal of stomatology, oral and maxillofacial surgery
2024

Simulation Training Approach for Cleft Lip and Palate Repair in Low-Income Countries.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2024

Maxillary Development and Dental Arch Relationships Following Early Two-Stage Palatoplasty: A Comparative Study.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2022

The study on the morphological changes of oropharynx in patients with complete unilateral cleft lip and palate after palatopharyngeal closure.

Frontiers in neuroscience
2022

Alterations in Facial Soft Tissue Thickness Post-Facemask Treatment in Noncleft Skeletal Class III and Bilateral Cleft Lip Palate Class III Patients.

Turkish journal of orthodontics
2022

Effects of maxillary advancement on maxillary incisor display in patients with skeletal Class III malocclusion and cleft lip and palate.

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
2022

Influence of Domestic Exposure to Polycyclic Aromatic Hydrocarbons on Women's Periconceptional Stage and Associated Risk of Oral Cleft in Offspring.

Journal of pharmacy &amp; bioallied sciences
2022

Soft Palate Mucosal Adhesion with Muscle Release: An Option in "Wide" Cleft Palates in a Cohort in Southern Africa.

The Journal of craniofacial surgery
2023

Speech Symptoms of Velopharyngeal Insufficiency and the Incidence of Secondary Speech Surgery in 10-Year-Old Children With Unilateral Cleft Lip and Palate: Comparison of 2 Randomized Surgical Methods for Primary Palatal Surgery.

The Journal of craniofacial surgery
2022

Cleft Palate in Apert Syndrome.

Journal of developmental biology
2022

Six-year post-surgical evaluation in the treatment protocols in the dental arches of children with oral cleft: longitudinal study.

Journal of applied oral science : revista FOB
2024

Impact of a Palatal Fistula After Cleft Palate Repair on Velopharyngeal Closure.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2022

Novel de novo missense mutation in the interferon regulatory factor 6 gene in an Italian infant with IRF6-related disorder.

Italian journal of pediatrics
2023

Is the Message Clear? Evaluation of Readability Levels for Cleft Lip, Cleft Palate, and Craniofacial Websites.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2023

Pleomorphic Adenoma of the Palate: A Rare Case in an Adolescent With Cleft lip and Palate.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2023

Differences in Practice in Alveolar Bone Grafting Among American Cleft Palate-Craniofacial Association Members.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2023

The First Hybrid International Educational Comprehensive Cleft Care Workshop.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2023

Occlusal Evaluation Using Modified Huddart and Bodenham Scoring System Following 2-Stage Palatoplasty With Hotz Plate: A Comparison Among 3 Different Surgical Protocols.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2022

Surgically treated congenital cleft palate in a 4-month-old kitten: medium-term clinical and CT assessment.

JFMS open reports
2023

Triple Layer Oronasal Fistula Repair Using Local Endonasal Flaps: Case Series of Three Patients.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2022

Prognosis of otitis media with effusion in pediatric patients with cleft palate during language-acquisition period treated by simultaneous tympanostomy tube placement with palatoplasty.

International journal of pediatric otorhinolaryngology
2023

Current Surgical Practice for Children Born with a Cleft lip and/or Palate in the United Kingdom.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2022

A predictor of a postoperative fistula after double-opposing Z-plasty in bilateral cleft lip and palate patients.

Journal of plastic, reconstructive &amp; aesthetic surgery : JPRAS
2022

Simultaneous Closure of the Cleft Alveolus and Hard Palate with Concomitant Bone Grafting.

Plastic and reconstructive surgery. Global open
2022

Novel approach for treating challenging implant-borne maxillary dental rehabilitation cases of cleft lip and palate: a retrospective study.

International journal of implant dentistry
2022

Incidence of fistula after primary cleft palate repair: a 25-year assessment of one surgeon's experience.

Archives of plastic surgery
2023

Cadaveric Study and Micro-Computed Tomography of the Anatomy of Palatine Aponeurosis and its Link to the Soft Palate Muscles and Pharyngeal Muscles.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2022

Tissue Augmenting Palatoplasty for the Treatment of Velopharyngeal Insufficiency.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2021

Cephalometric Analysis of Hard and Soft Tissue Changes Following Anterior Maxillary Osteotomy Distraction in Cleft Maxillary Hypoplasia.

Journal of maxillofacial and oral surgery
2022

Five-year prospective fistula audit in a single center. TIG training negates consultant learning curve, but surgeons should beware the mid-range palatal defect.

Journal of plastic, reconstructive &amp; aesthetic surgery : JPRAS
2021

The Smile Index: Part 3. A Simple, Prognostic Severity Scale for Unilateral Cleft Palate.

Plastic and reconstructive surgery. Global open
2021

The Application of Buccal Fat Pad to Cover Lateral Palatal Defect Causes Early Mucolization.

Cureus
2021

Noggin Overexpression Impairs the Development of Muscles, Tendons, and Aponeurosis in Soft Palates by Disrupting BMP-Smad and Shh-Gli1 Signaling.

Frontiers in cell and developmental biology
2021

Characterization of phenotypes and predominant skeletodental patterns in pre-adolescent patients with Pierre-Robin sequence.

Korean journal of orthodontics
2021

Complications During Grayson Presurgical Nasoalveolar Molding Method in Nonsyndromic Infants With Complete Unilateral Cleft Lip and Palate.

The Journal of craniofacial surgery
2021

Use of a buccinator myomucosal flap and bilateral pedicled buccal fat pad transfer in wide palatal fistula repair: a case report.

Archives of craniofacial surgery
2022

Ectomesenchymal Chondromyxoid Tumor: A Rare Association With an Asymmetrical Soft Palate Cleft.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2021

Three-Dimensional Anatomy of the Palatopharyngeus and Its Relation to the Levator Veli Palatini Based on Micro-Computed Tomography.

Plastic and reconstructive surgery
2022

Nasal asymmetry changes during growth and development in 6- to 12-year-old children with repaired unilateral cleft lip and palate: A 3D computed tomography analysis.

Journal of anatomy
2022

Continuous Multidisciplinary Care for Patients With Orofacial Clefts-Should the Follow-up Interval Depend on the Cleft Entity?

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2022

Quantitative Evaluation of Palatal Lengthening After Cleft Palate Repair When a Buccal Flap Is Routinely Combined With Furlow's Z-Plasty.

Annals of plastic surgery
2022

Speech Outcome and Self-Reported Communicative Ability in Young Adults Born With Unilateral Cleft Lip and Palate: Comparing Long-Term Results After 2 Different Surgical Methods for Palatal Repair.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2022

Early Communication Behaviors in Infants With Cleft Palate With and Without Robin Sequence: A Preliminary Study.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2021

An Observational Study to Evaluate Association Between Velopharyngeal Anatomy and Speech Outcomes in Adult Patients With Severe Velopharyngeal Insufficiency.

The Journal of craniofacial surgery
2022

Tessier 30 Facial Clefts-A Literature Review of 72 Cases (1996-2020), Suggested Treatment Protocol, Outcome Measures, Minimum Dataset for Future Case Reports, and Registries.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2021

Three-Dimensional Facial Soft Tissue Changes After Orthognathic Surgery in Cleft Patients Using Artificial Intelligence-Assisted Landmark Autodigitization.

The Journal of craniofacial surgery
2021

Characteristics of craniofacial morphology and factors affecting them in patients with isolated cleft palate.

PeerJ
2022

A Preliminary Study of Anatomical Changes Following the Use of a Pedicled Buccal Fat Pad Flap During Primary Palatoplasty.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2022

Cleft Lip and/or Palate in Infants Prenatally Exposed to Opioids.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2022

Dental Arch Relationship Outcomes Following 2-Stage Palatoplasty for Japanese Patients With Complete Unilateral Cleft Lip and Palate: A 3-Center Study.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2021

Cheek soft tissue prediction in cleft orthognathic surgery: A 3D computer-assisted investigation with comparative analysis.

Journal of plastic, reconstructive &amp; aesthetic surgery : JPRAS
2021

Impairment in facial expression generation in patients with repaired unilateral cleft lip: Effects of the physical properties of facial soft tissues.

PloS one
2021

Evaluation of masticatory function in patients with cleft lip and/or palate.

European journal of oral sciences
2021

Primary Palatal Surgery in Nonsyndromic Cleft Palate Children and Velopharyngeal Insufficiency Correction Outcomes.

The Journal of craniofacial surgery
2021

Evaluation of fistula rates in three cleft palate techniques without relaxing incisions.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
2021

Speech and Audiology Outcomes After Single-Stage Versus Early 2-Stage Cleft Palate Repair.

Annals of plastic surgery
2021

A novel modification of Bardach's two-flap palatoplasty for the repair of a difficult cleft palate.

Archives of plastic surgery
2021

Registry-Based Study of Prevalence of Cleft Lip/Palate in Thailand from 2012 to 2015.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2020

CAD/CAM Engineered Patient-Specific Impants as a Reposition Device in Le Fort I and Modified Subcondylar Osteotomies: Case Report of Facial Deformity Correction in Acromegaly.

Craniomaxillofacial trauma &amp; reconstruction
2021

Soft Palate Fistula in a Patient With Normal Palate as a Rare Complication After Septoplasty.

The Journal of craniofacial surgery
2021

Orthodontic Management of a Palatal Fistula in a Patient With Pierre Robin Sequence Using 3D Intraoral Scanning and Computer-Aided Design.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2021

Incidence of Symptomatic Submucous Cleft Palate in the Netherlands: A Retrospective Cohort Study Over a Period of 22 Years.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2020

A Cadaveric Study of the Buccal Fat Pad: Implications for Closure of Palatal Fistulae and Donor-Site Morbidity.

Plastic and reconstructive surgery
2022

A Pitfall in Prenatal Ultrasonic Detection of Submucous Cleft Palate.

Ear, nose, &amp; throat journal
2020

Surgical Reconstruction of Cocaine-Induced Cleft Lip: A Case Report.

The Permanente journal
2020

An Evaluation of Wound Healing Efficacy of a Film Dressing Made from Polymer-integrated Amnion Membrane.

Organogenesis
2020

A Global Evaluation of Surgical Techniques and Results of Unilateral Cleft Lip Repairs.

The Journal of craniofacial surgery
2020

Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions.

Journal of clinical medicine
2021

The Effect of Surgical Timing on 30-Day Outcomes in Cleft Palate Repair.

Plastic and reconstructive surgery
2021

A new two-dimensional sonographic approach to the assessment of the fetal hard and soft palates.

Journal of clinical ultrasound : JCU
2020

Simulation Surgery Using 3D 3-layer Models for Congenital Anomaly.

Plastic and reconstructive surgery. Global open
2021

Assessment of the New L Pharyngeal Flap for Velopharyngeal Insufficiency.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2021

A Toolbox of Surgical Techniques for Palatal Fistula Repair.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2021

For Patients With Isolated Cleft Palate Does Revision Palatoplasty Have an Increased Risk of Inpatient Complication Compared to Primary Palatal Repair?

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2020

Buccal fat pad in cleft palate repair- An institutional experience of 27 cases.

International journal of pediatric otorhinolaryngology
2020

Techniques and results of palate fistula repair following palatoplasty: a 234-case multicenter study.

Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica
2020

Andrew's bridge system: A boon for huge ridge defect in aesthetic zone.

Journal of oral biology and craniofacial research
2022

Prospective evaluation of the effect of early nasal layer closure on definitive repair in cleft palate patients.

Brazilian journal of otorhinolaryngology
2020

Receptive and Expressive Vocabulary Skills and Their Correlates in Mandarin-Speaking Infants with Unrepaired Cleft Lip and/or Palate.

International journal of environmental research and public health
2020

Maxillary protraction in patients with unilateral cleft lip and palate : Evaluation of soft and hard tissues using the Alt-RAMEC protocol.

Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie
2020

[Palatal fistula rate after Huaxi Sommerlad-Furlow palatoplasty].

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
2020

Speech of Patients With Unilateral Complete Cleft Lip and Palate: Comparison of Three Different Surgical Protocols for Primary Repair.

The Journal of craniofacial surgery
2020

Temporal Muscle Flap as a Treatment of an Extensive Cleft Palate in an Adult Patient.

The Journal of craniofacial surgery
2020

Alexis Retractor: Institutional Experience of Its Applications in Head and Neck Surgery and Review of the Literature.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2020

An Intraoperative Salvage After Transection of the Greater Palatine Artery During Cleft Palate Repair: A Case for Buccal Fat and Buccal Myomucosal Flaps.

The Journal of craniofacial surgery
2020

Scandcleft Project Trial 3: Comparison of Speech Outcomes in Relation to Sequence in 2-Stage Palatal Repair Procedures in 5-Year-Olds With Unilateral Cleft Lip and Palate.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2020

Occlusion at 5 Years of Age Following Hard Palate Closure With Vestibular Flap.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2020

Scandcleft Project Trial 2-Comparison of Speech Outcome in 1- and 2-Stage Palatal Closure in 5-Year-Olds With UCLP.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2020

Longitudinal study of the development of obstruent correctness from ages 3 to 5 years in 108 Danish children with unilateral cleft lip and palate: a sub-study within a multicentre randomized controlled trial.

International journal of language &amp; communication disorders
2019

Wound Complications, Additional Ventilation Requirement, Prolonged Stay, and Readmission in Primary Palatoplasty: A Risk Factor Analysis of 3616 Patients.

Plastic and reconstructive surgery
2020

Range and timing of surgery, and surgical sequences used, in primary repair of complete unilateral cleft lip and palate: The Cleft Care UK study.

Orthodontics &amp; craniofacial research
2020

Do Infant Cleft Dimensions Have an Influence on Occlusal Relations? A Subgroup Analysis Within an RCT of Primary Surgery in Patients With Unilateral Cleft Lip and Palate.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2019

Dynamic activation of Wnt, Fgf, and Hh signaling during soft palate development.

PloS one
2020

Scandcleft randomized trials of primary surgery for unilateral cleft lip and palate: maxillary growth at eight years of age.

European journal of orthodontics

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Orofacial clefting in PHF6-related B&#xf6;rjeson-Forssman-Lehmann syndrome.
    BMJ case reports· 2026· PMID 41741118mais citado
  2. Design of Buccinator Flaps for Oronasal Fistula Repair: A Technical Review and Case Series.
    Eplasty· 2026· PMID 41837171mais citado
  3. Minor modification of soft palate surgical technique resulted in a considerable increase of residual cleft dimensions for unilateral cleft lip and palate.
    Journal of plastic surgery and hand surgery· 2026· PMID 41636578mais citado
  4. Doble Aligner Nasoalveolar Molding: A New Approach of Digital Protocol for Cleft Lip and Palate in Newborn Patients.
    International journal of clinical pediatric dentistry· 2026· PMID 41624371mais citado
  5. Comparative analysis of soft tissue response after orthognathic surgery in patients with and without cleft using 3D imaging: A preliminary study.
    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery· 2026· PMID 41546919mais citado
  6. Mast cell mediators in hereditary angioedema.
    Orphanet J Rare Dis· 2026· PMID 41832580recente
  7. Prenatal Molecular Diagnosis of COL2A1-Associated Stickler Syndrome: Genotype-Phenotype Correlation in a Resource-Limited Healthcare Setting.
    Int J Mol Sci· 2026· PMID 41828453recente
  8. Platelet gene signatures detecting pulmonary artery stenosis in patients with pulmonary hypertension.
    Orphanet J Rare Dis· 2026· PMID 41827036recente
  9. The global impact of imiglucerase therapy in children with Gaucher disease types 1 and 3: a real-world analysis from the International Collaborative Gaucher Group Gaucher Registry.
    Orphanet J Rare Dis· 2026· PMID 41821052recente
  10. Monogenic lupus with SLC7A7 mutations: a retrospective study from a Chinese center.
    Orphanet J Rare Dis· 2026· PMID 41821046recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:664372(Orphanet)
  2. MONDO:0971092(MONDO)
  3. Busca completa no PubMed(PubMed)
  4. Artigo Wikipedia(Wikipedia)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

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Fenda palato mole e duro
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Fenda palato mole e duro

ORPHA:664372 · MONDO:0971092
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