Insulinoma

Diagnosing and Treating Low Blood Sugar Levels

NCT00001276

Endoscopic Ultrasound-guided Radiofrequency Ablation for Upper Gastrointestinal Tract Lesions

NCT07272187

Glucagon-like Peptide-1 Receptor PET/CT in GLP-1R Related Disease

NCT06725693

Fluorodopa F 18 in Congenital Hyperinsulinism and Insulinoma

NCT02021604

Temozolomide With or Without Capecitabine in Treating Patients With Advanced Pancreatic Neuroendocrine Tumors

NCT01824875

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NCT00001276 · Diagnosing and Treating Low Blood Sugar LevelsRecrutando

NCT07272187 · Endoscopic Ultrasound-guided Radiofrequency Ablation for Upp…Recrutando

NCT06725693 · Glucagon-like Peptide-1 Receptor PET/CT in GLP-1R Related Di…Recrutando

NCT02021604 · Fluorodopa F 18 in Congenital Hyperinsulinism and InsulinomaRecrutando

NCT01824875 · Temozolomide With or Without Capecitabine in Treating Patien…Ativo

Outros ensaios clínicos

64 ensaios clínicos encontrados, 7 ativos.

Distribuição por fase

NCT05735912 · EUS-RFA Versus Surgery for Pancreatic Insulinoma (ERASIN-RCT…Ativo

NA

NCT03583528 · DOTATOC PET/CT for Imaging NET PatientsAtivo

NCT07340437 · Clinical Study of 18F-Exendin-4 in InsulinomaConcluído

NCT01916148 · 18F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreat…AVAILABLE

NCT00655655 · Everolimus and Vatalanib in Treating Patients With Advanced …Concluído

NCT01525082 · Capecitabine, Temozolomide, and Bevacizumab for Metastatic o…Concluído

NCT04452396 · CGM (Continuous Glucose Monitoring) Use in Diagnosis of Spon…Encerrado

NA

NCT05523778 · A Multi-center Study to Evaluate the Efficacy and Safety of …UNKNOWN

NA

NCT04979611 · The Clinical Application of 68Ga-NOTA-exendin-4 PET/CT in De…UNKNOWN

NCT02031536 · Everolimus in Patients With Pancreatic Neuroendocrine Tumors…Encerrado

NCT02431715 · 18F-FDOPA PET in Neuroendocrine TumoursNO_LONGER_AVAILABLE

NCT04915144 · 177Lu-DOTATOC for the Treatment of Patients With Somatostati…Cancelado

NCT05034783 · [68Ga]Ga-HBED-CC-exendin-4 and [68Ga]Ga-NOTA-exendin-4 PET/C…UNKNOWN

EARLY_PHASE1

NCT03147768 · Laser Tissue Welding - Distal Pancreatectomy Sealing StudyConcluído

NCT02259725 · Regorafenib in Treating Patients With Advanced or Metastatic…Concluído

Ver todos no ClinicalTrials.gov

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Publicações mais relevantes

Timeline de publicações

2.252 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 2.252

#1

Development and characterization of experimental β-cell senescence models revealing autophagy defects and altered stimulus-secretion coupling.

GeroScience2026 Mar 09

Aging is a major contributor to β-cell dysfunction in type 2 diabetes, with cellular senescence increasingly recognized as an important underlying mechanism. Here, we established a doxorubicin (DOX)-induced senescence model using MIN6 mouse insulinoma β-cell line to elucidate the mechanisms by which senescence remodels organelle homeostasis and insulin secretion. Senescence was validated by senescence-associated β-galactosidase positivity, p16INK4a/p21/p53 upregulation, and cell cycle arrest. Using mitochondrial MitoTimer and cytochrome c oxidase subunit 8-enhanced green fluorescent protein-mCherry reporters, along with a custom Insulin-Timer construct, we visualized organelle aging and assessed β-cell functions via glucose-stimulated insulin secretion, insulin content, mitochondrial membrane potential, Ca2⁺ imaging, and reactive oxygen species production analyses. Senescent β-cells accumulated mitochondria and insulin granules with prolonged residence time since synthesis and exhibited defective clearance and exaggerated mitochondrial hyperpolarization accompanied by altered Ca2⁺ influx and enhanced reactive oxygen species production upon glucose stimulation. Despite the reduced insulin content, secretion normalized to storage was disproportionately enhanced, suggesting remodeled stimulus-secretion coupling; similar findings were also observed in the p16INK4a/p21/p53 overexpression model. This study provides evidence that DOX-induced β-cell senescence serves as a surrogate model linking DNA damage to impaired mitochondrial and insulin granule clearance. By mimicking aspects of age-related β-cell dysfunction, this model highlighted autophagy defects as drivers of organelle retention and provided insights into the mechanisms by which senescence reshapes stimulus-secretion coupling, thereby enhancing our understanding of β-cell senescence in diabetes. Importantly, this experimentally tractable model provides a platform to test interventions targeting senescent-cell burden or senescence-associated dysfunction and to dissect mechanisms of β-cell functional remodeling.

#2

Evaluation of Clinical, Laboratory and Immunological Characteristics in the Early Onset (Diagnosed Age < 30 Years Old) Patients With Type 2 Diabetes.

Journal of Korean medical science2026 Feb 23

The classification of early onset (< 30 years old) patients with diabetes mellitus (DM) as either type 1 diabetes (T1D) or type 2 diabetes (T2D) can be a challenge due to their similar overlapping phenotypes. In this study, we attempted to utilize various clinical and laboratory characteristics in combination with immunological factors in the blood to determine whether it would be possible to distinguish and more accurately characterize our patients as T2D. Electronic medical records were evaluated to obtain information categorized as either early onset patients with DM (n = 102) and patients with T1D (n = 89). Using the stored serum from these patients, autoantibodies of anti-insulinoma associated 2 (IA2), anti-zinc transporter 8 (ZnT8) and anti-glutamic acid decarboxylase antibody (GAD) were measured. In the clinical characteristics, early onset patients with DM (n = 102) were younger (31.7 ± 7.0 years old, P < 0.01), more overweight (28.1 ± 5.5 kg/m², P < 0.05), shorter duration of diabetes (10.4 ± 7.3 years, P < 0.01) and a more prevalent family history of diabetes (81%, P < 0.01) than patients with T1D. The laboratory values from early onset patients with DM exhibited lower glycated hemoglobin A1c (8.0 ± 2.1%, P < 0.01) and glucose levels (165 ± 73 mg/dL, P < 0.01) with conversely higher C-peptide levels (2.2 ± 1.2 ng/mL, P < 0.01). Measurements of immunological factors, demonstrated that the prevalence of anti-ZnT8 (2%) and anti-GAD antibody (2%) in early onset patients with DM was significantly lower (P < 0.01) compared to patients with T1D (13% for anti-ZnT8 and 38% for anti-GAD). The prevalence of anti-IA2 was not significantly different between early onset patients with DM (13%) versus patients with T1D (11%). In the multivariate logistic regression analysis, C-peptide level (B, 4.453; standard error [SE], 0.844; Wald, 27.808; P < 0.001) was the strongest independent factor to distinguish early onset patients with DM as T2D. After adjusting C-peptide level, family history of diabetes (B, 0.830; SE, 0.420; Wald, 3.909; P = 0.048), body mass index (BMI) (B, 0.111; SE, 0.039; Wald, 8.167; P = 0.004) and the relative negative status of anti-GAD (B, -2.041; SE, 0.597; Wald, 11.670; P < 0.001) were determining factors in our analyses. In this study, our findings suggested that early onset patients with DM may be more accurately diagnosed as T2D if they have a compilation of elevated C-peptide levels, higher BMI, more prevalent history of familial diabetes and the absence of detecting anti-GAD antibodies.

#3

Targeted near-infrared imaging utilizing a cathepsin-activated fluorophore for the intraoperative detection of canine insulinoma.

PloS one2026

The aim of this study was to evaluate the use of cathepsin-activated intraoperative near-infrared (NIR) imaging to detect insulinomas in dogs, a spontaneous large animal model for human disease. A prospective, pilot clinical trial was performed on dogs with naturally occurring insulinomas undergoing exploratory laparotomy. Each dog underwent routine preoperative diagnostic assessment, and a cathepsin-activated fluorophore (VGT-309) was administered intravenously 1-2 days preoperatively. All intraoperative findings with visible light and NIR imaging were recorded and mean NIR fluorescence intensity of tumors and grossly normal pancreas were quantified. Excision of any identified primary tumor and suspected metastatic lesions was performed. All excised tissues underwent histologic evaluation and immunohistochemistry (IHC) for cathepsin B expression. Descriptive statistics were calculated, and differential fluorescence intensity and cathepsin B expression between the pancreatic mass and adjacent grossly normal pancreatic tissue were assessed for statistical significance via paired t tests with p < 0.05 used for significance. Six dogs were enrolled. No adverse events occurred secondary to administration of the imaging agent. In situ, insulinomas had significantly greater mean fluorescence intensities than the surrounding pancreas, and the median tumor to background ratio was 1.906 (range 1.286-2.556). One dog had an occult pancreatic mass that was identified intraoperatively with NIR guidance. Background fluorescence of liver and lymph nodes was observed in all cases, and one dog was diagnosed with nodal and hepatic metastasis. Histologic tumor margins correlated with margins of NIR fluorescence. Cathepsin B expression was determined to be significantly greater in the pancreatic tumor compared to adjacent non-neoplastic pancreas via IHC, and there was no overlap in the range of median IHC-positive proportion values for these tissues. However, there was overlap in the range of IHC-positive proportion values for neoplastic pancreatic samples and lymph node and liver tissues. The findings of this pilot study support further investigation of cathepsin-activated NIR imaging to enhance intraoperative canine insulinoma localization and margin evaluation. Future studies are needed to further characterize and optimize the utility of targeted NIR imaging, particularly to identify metastatic lesions, for canine insulinoma, which may serve as an effective translational model for humans with pancreatic neuroendocrine tumors.

#4

Type 1 Diabetes: A Review.

JAMA2026 Mar 24

Type 1 diabetes is defined by hyperglycemia due to autoimmune destruction of the insulin-producing beta cells in the pancreas, leading to insulin deficiency, and accounts for 5% to 10% of all cases of diabetes. Type 1 diabetes affects approximately 2 million people in the US and 8.4 million people worldwide and is associated with microvascular and macrovascular complications such as retinopathy, nephropathy, neuropathy, and cardiovascular disease. Ninety percent to 95% of people with type 1 diabetes have at least 1 autoantibody when they are diagnosed with diabetes. These autoantibodies include autoantibodies to insulin, glutamic acid decarboxylase 65, insulinoma-associated 2, and zinc transporter 8 autoantibodies and are absent in type 2 diabetes or monogenic diabetes (a rarer form of diabetes caused by a single genetic variant). These autoantibodies are present before clinical symptoms develop and can identify early stages of type 1 diabetes. Up to 44% of children and 23% of adults with type 1 diabetes present with diabetes-related ketoacidosis. Type 1 diabetes is most commonly diagnosed between ages 10 and 14 years, but the median age of diagnosis in the US is 24 years. People with type 1 diabetes require lifelong insulin replacement, which can be administered via subcutaneous injection or insulin pump. Insulin regimens that mimic normal physiology include long-acting basal insulin (eg, glargine or degludec) administered once to twice daily and rapid-acting bolus insulin (eg, aspart or lispro) administered prior to meals that contain carbohydrates and during periods of hyperglycemia. Randomized clinical trials have demonstrated that continuous glucose monitors with insulin pumps, which automatically adjust insulin delivery in response to glucose levels, result in less hypoglycemia and improved hemoglobin A1c levels (with the greatest improvement occurring in those with higher starting levels [eg, >8.0%]). Type 1 diabetes accounts for 5% to 10% of all cases of diabetes and is characterized by the presence of islet autoantibodies in 90% to 95% of patients. Lifelong use of insulin therapy is currently required for treatment of type 1 diabetes.

#5

Endoscopic ultrasound-guided radiofrequency ablation of pancreatic insulinoma.

BMJ case reports2026 Jan 27

A man in his mid-30s presented to the emergency department following a motor vehicle accident with critically low blood glucose of 1.1 mmol/L (3.9-5.6 mmol/L) noted by emergency medical service and altered mental status. The patient reported progressive symptoms including tremor, sweating and difficulty concentrating, requiring continuous eating throughout the day, weight gain and hypoglycaemia unawareness.A 72-hour supervised fast confirmed endogenous hyperinsulinaemia, after 5 hours, inappropriately elevated insulin of 26 pmol/L (diagnostic cut-off ≥18 pmol/L) and C-peptide >0.33 nmol/L (expected <0.2 nmol/L) with glucose 2.2 mmol/L (3.9-5.6 mmol/L). While CT and DOTATATE-positron emission tomography were negative, endoscopic ultrasound (EUS) and biopsy identified a 13 mm pancreatic head well-differentiated neuroendocrine tumour.EUS-guided radiofrequency ablation (EUS-guided RFA) achieved immediate symptom resolution with normal postprocedure biochemical profile. In this case, EUS successfully identified the lesion when conventional imaging was negative and EUS-guided RFA resulted in successful treatment in this patient.

Publicações recentes

A Case of Functional Para-Aortic Paraganglioma Causing Accelerated Hypertension in an HIV-Positive Patient With Negative 68Ga-DOTATATE PET/CT Findings: Successful Laparoscopic Management.

Cureus2026 Mar

Real-world treatment outcomes for pancreatic neuroendocrine tumours: a single tertiary referral institute experience.

ESMO Gastrointest Oncol2026 Mar

Insulinoma-associated 1 promotes neurogenic proliferation of cortical basal progenitors but is largely dispensable for projection neuron production.

bioRxiv2026 Apr 6

Whole-exome sequencing unveils novel potential gene mutations involved in primary renal small cell carcinoma.

Oncol Lett2026 May

Adjuvant nutritional management of canine insulinoma: A case report.

Res Vet Sci2026 Apr 8

Ver todas no PubMed

📚 EuropePMC2.971 artigos no totalmostrando 196

Anti-secretory and anti-proliferative actions of next-generation dual subtype 2 and 5 somatostatin receptor ligands in neuroendocrine tumor models.

Frontiers in oncology

Journal of neurological surgery reports

Vestibular Dysfunction as a Novel Presentation of Middle Ear Neuroendocrine Tumor.

[18F]FB(ePEG12)12-Exendin-4 positron emission tomography/magnetic resonance imaging for precise preoperative localization of a pancreatic-head insulinoma: a case report with review of literature.

Endocrine journal

Journal of veterinary internal medicine

Clinical signs, management, and survival of 278 dogs diagnosed with insulinoma under primary veterinary care in the United Kingdom.

Diabetes, metabolic syndrome and obesity : targets and therapy

Clinical Characteristics and Risk Factors of Exogenous Insulin Antibody Syndrome in Patients with Diabetes: A Retrospective Cross-Sectional Study.

Diabetology international

Insulinoma complicated with hypergastrinemia in a subject with type 2 diabetes mellitus: a case report.

Development and characterization of experimental β-cell senescence models revealing autophagy defects and altered stimulus-secretion coupling.

GeroScience

Contrast-enhanced endoscopic ultrasound-guided additional ethanol ablation after early detection of occult residual pancreatic insulinoma.

Endoscopy

A Rare Case of Asymptomatic Insulinoma with Mesocolonic Lymph Node Metastases and Long-Term Stability.

Surgical case reports

BMC medical informatics and decision making

Explainable deep learning and radiomics integration for differentiating insulinomas from NF-PNETs in EUS imaging.

Journal of diabetes and metabolic disorders

A rare case of ectopic cushing's syndrome caused by renal neuroendocrine tumor.

A Case of Antibody-Mediated Recurrent Hypoglycemia in a Patient With Mixed Connective Tissue Disease.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

Transcriptomic profiling of insulinomas reveals a new "low-endocrine" subtype with low YY1 expressions.

Establishment of patient-derived xenografts for neuroendocrine tumors in the avian embryo model.

Journal of Korean medical science

Evaluation of Clinical, Laboratory and Immunological Characteristics in the Early Onset (Diagnosed Age < 30 Years Old) Patients With Type 2 Diabetes.

Targeted near-infrared imaging utilizing a cathepsin-activated fluorophore for the intraoperative detection of canine insulinoma.

PloS one

Paralytic Ileus as the Initial Manifestation of New-Onset Type 1 Diabetes Without Diabetic Ketoacidosis: A Case Report.

Journal of biochemical and molecular toxicology

Arachidonic Acid and Lipoxin A4 Protect Pancreatic β-Cells and Improve Hyperglycemia Induced by Bleomycin.

Ventricular fibrillation triggered by recurrent hypoglycemia in a patient with insulinoma associated with MEN1: case report and review of literature.

Endocrine journal

The American journal of case reports

Insulin Autoimmune Syndrome Associated With Hashimoto Thyroiditis and Nodular Thyroid Disease: Clinical Management With Flash Glucose Monitoring and Prednisolone Therapy.

Type 1 Diabetes: A Review.

JAMA

The Journal of endocrinology

Insulinoma with postprandial hypoglycemia and characteristic expression of GLUT2/GCK/GLP-1R.

Thymic Atypical Carcinoid Mimicking Recurrent Type A Thymoma on Frozen Section: A Diagnostic Pitfall Resolved by Intraoperative Imprint Cytology.

The American Journal of dermatopathology

When Morphology Misleads: The Diagnostic Challenge of Large-Cell Variant Merkel Cell Carcinoma.

AACE endocrinology and diabetes

Cholecystectomy-Associated Postprandial Hypoglycemia.

Three Interesting Cases of Hypoglycemia: A Case Series.

Oral delivery of GLP-1 analogues by recombinant Lactococcus lactis restores pancreatic islet structure through intestinal mucosal absorption in diabetic mice.

EBioMedicine

Systematic review of multimodal management strategies for Insulinoma-Induced hypoglycaemia: current evidence and future directions.

Endocrine

Journal of neurosurgery. Case lessons

Pediatric craniopharyngioma: when hypoglycemia reveals a brain tumor. Illustrative case.

Iranian journal of pathology

Clinical Outcomes and Predictive Factors in Adrenalectomy: A Retrospective Cohort Study.

Noninsulinoma Hyperinsulinemic Hypoglycemia Syndrome Emerging Post-Nissen Fundoplication.

Unveiling a Novel MT-TS1 m.7479G>A in Mitochondrial Diabetes: The Critical Role of mtDNA Sequencing in Atypical Cases.

Investigating the Role of Diet-Manipulated Gut Bacteria in Pathogenesis of Type 2 Diabetes Mellitus-An In Vitro Approach.

Nutrients

Endoscopic ultrasound-guided radiofrequency ablation of pancreatic insulinoma.

BMJ case reports

Oxford medical case reports

Unmasking an insulinoma: recurrent Hypoglycemia in a young patient following GLP-1 receptor agonist therapy -A case report.

Insulinoma in a Young Patient With Focal Seizures: A Case Report of a Neurological Diagnostic Challenge.

Clinical case reports

Journal of toxicologic pathology

Association between spontaneous neurogenic atrophy of the femoral muscle and islet cell tumors in aged F344 rats.

Journal of toxicologic pathology

A canine insulinoma with amphicrine differentiation: morphological and immunohistochemical characteristics.

A case report of enduring benefit of sequential PRRT in malignant insulinoma.

EJNMMI reports

Shift in secretory profile of a pNET: from indolent glucagonoma to aggressive insulinoma - a case report.

Germline and somatic mutations in histologically atypical congenital hyperinsulinism.

Functionally coupled ion channels begin co-assembling at the start of their synthesis.

eLife

Non-HLA risk variants in a type 1 diabetes pediatric population: Clinical and autoimmune profiles.

Anales de pediatria

The Journal of nutritional biochemistry

Dietary zinc deficiency regulates the ROS/TLR4/NF-κB pathway to induce pancreatic inflammation and cell death in mice.

[A case of recurrent hypoglycemic coma episodes associated with primary biliary cholangitis and literature review].

Zhonghua nei ke za zhi

Elevated blood levels of liver-expressed antimicrobial peptide 2 in patients with insulinoma and its expression in insulinomas.

HPB : the official journal of the International Hepato Pancreato Biliary Association

A systematic review of the application of indocyanine green in pancreatic neuroendocrine tumors: Technical details, surgical indications, and outcomes.

VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy

Tumor enhancement by magnetic resonance imaging after endoscopic ultrasound-guided radiofrequency ablation for small pancreatic neuroendocrine tumors.

Applied biochemistry and biotechnology

Biogenic ZnO Nanoparticles from Allium Cepa and Tagetes erecta: Synthesis, Characterization and its Antidiabetic, Antioxidant Evaluation and Cytotoxic Studies against Mouse Insulinoma (MIN6) Cell Line.

Insulinoma in pregnancy: is diet alone enough to treat insulinoma?

Endokrynologia Polska

Diabetes, obesity & metabolism

Accuracy and reliability of a continuous glucose monitoring system with a focus on hypoglycaemia.

International journal of surgical pathology

Sinonasal Lymphoepithelial Carcinoma With Insulinoma-Associated Protein 1 (INSM1) Expression: A Potential Pitfall.

Therapeutic advances in gastrointestinal endoscopy

EUS-guided radiofrequency and ethanol ablation of pancreatic insulinomas: a single-center experience.

Cellular and molecular gastroenterology and hepatology

DOCK10 Regulates Insulin Hypersecretion in Insulinoma and Serves as a Diagnostic and Therapeutic Target.

Minimally Invasive Resection of Occult Insulinomas-Experience from an ENETS Centre of Excellence and Review of the Literature.

Clinica chimica acta; international journal of clinical chemistry

GADA as a biomarker for type 1 diabetes.

Diving and hyperbaric medicine

Hyperbaric oxygen therapy for hypoglycaemic encephalopathy due to insulinoma: a case report.

Gallbladder large cell neuroendocrine carcinoma in a patient with multiple myeloma: a case report and literature review.

Frontiers in oncology

Insulinoma Unmasked By Tirzepatide: A Rare Case of Postprandial Hypoglycemia In a Nondiabetic Patient.

A Rare Case of Presumed Insulin-Like Growth Factor 2 (IGF-2)-Mediated Hypoglycemia.

A case-based review of urachal carcinoma with mixed small cell neuroendocrine and adenocarcinoma components, with one new case report and analysis of nine published cases.

Ecotoxicology and environmental safety

Mono-(2-ethylhexyl) phthalate impairs insulin secretion in rat insulinoma cells by inducing ferroptosis via oxidative stress.

A Small-Molecule Mitofusin 1 Agonist Enhances Islet Survival Under Hypoxic Conditions In Vitro and Improves Transplantation Outcomes.

Biomolecules

Quantitative Conspicuity of Pancreatic Canine Insulinoma: A Comparison of Dynamic 4D CT and Dual-Source, Dual-Energy Bolus-Triggered Multiphase CT Imaging.

Veterinary sciences

Glucose shields RINm5F beta cells against arsenic-induced apoptosis.

Scientific reports

Rare Causes of Hypoglycemia-Lessons from Case Reports.

bioRxiv : the preprint server for biology

Dielectrophoresis Reveals Stimulus-Induced Remodeling of Insulin Granule Subpopulations.

Successful Endoscopic Ultrasound-Guided Radiofrequency Ablation for Symptomatic Insulinoma in a High-Risk Elderly Patient.

ACG case reports journal

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

Types of pancreatic lesions and the mutational landscape of the VHL gene in patients with von Hippel-Lindau disease.

68 Ga-NODAGA-EXENDIN-4 PET/CT in the Detection or the Exclusion of Occult Sporadic Insulinomas.

The veterinary clinics of North America. Exotic animal practice

Clinical Anatomy, Physiology, and Common Diseases of the Pancreas in Exotic Pets.

Developing 68Ga-Labeled Exendin(9-39) Derivatives for PET Imaging of Insulinomas.

Bioconjugate chemistry

Endocrine oncology (Bristol, England)

Enucleation for pancreatic neuroendocrine tumors: short- and long-term outcomes in a forty-year single-center experience.

A Case of Pediatric Pancreatic Insulinoma Diagnosed 4 Years after the Onset.

Surgical case reports

Revista de gastroenterologia de Mexico (English)

Gastroenteropancreatic neuroendocrine neoplasms: Clinical-pathologic analysis of 48 cases treated at the Hospital Ángeles del Pedregal in Mexico City between 2018 and 2024.

Efficacy and Safety of Tirzepatide in Refractory Hypoglycemia Associated with Esophagojejunostomy.

Virchows Archiv : an international journal of pathology

Immunohistochemical expression of Ki-67, INSM1, and SSTR2A in medullary thyroid carcinoma: correlation with tumour size, vascular invasion, and biochemical outcome.

Microfluidic device for islet conformal coating with a polyethylene glycol-based hydrogel: innovating cell immunoprotection strategies in type 1 diabetes.

Lab on a chip

Revista da Associacao Medica Brasileira (1992)

Diagnostic and prognostic utility of insulinoma-associated protein 1, insulin gene enhancer protein 1, and secretagogin in pheochromocytoma.

Investigational new drugs

The role of dinutuximab beta with beta cell function, apoptosis, and proliferation: new approaches to proteomic analysis of insulinoma.

The Journal of clinical endocrinology and metabolism

EUS-Guided Radiofrequency Ablation as a Minimally Invasive Treatment for Insulinomas-A Single-Center Experience.

Diabetology international

A case of type 1 diabetes mellitus with a single-positive zinc transporter 8 antibody who developed diabetic ketoacidosis during chemotherapy for colorectal cancer.

An Unexpected Manifestation of Non-islet Cell Tumor Hypoglycemia in Pancreatic Ductal Adenocarcinoma.

Novel immunohistochemical assay utilizing the INSM1 (SP493) antibody demonstrates high specificity and sensitivity in detecting primary neuroendocrine lung neoplasms.

Diagnostic pathology

Quality of Life After Pancreatic Surgery for Neuroendocrine Tumors of the Pancreas: Observational Study of Long-Term Outcomes.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

OTUB1 Modulates Ferroptosis by Regulating SLC7A11 Ubiquitination in Pancreatic β-Cells.

The American journal of medicine

Multiple endocrinopathies presenting simultaneously with insulinoma as the leading manifestation.

Endoscopic ultrasound-guided radiofrequency ablation for a pancreatic insulinoma: a novel endoscopic management strategy.

Endoscopy

Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology

A 14-yr-old boy with a pathogenic MEN1 variant was diagnosed with asymptomatic insulinoma during routine follow-up.

Identification of Peripheral Blood Endotypes Associated With Age in Pediatric Type 1 Diabetes.

Pediatric diabetes

Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology

A Japanese infant with fulminant type 1 diabetes with disease-sensitive CSAD polymorphism and HLA haplotype.

Archive of clinical cases

Insulinoma initially misdiagnosed as migraine.

Diagnostic Performance of Exendin-4 PET/CT in Localizing Insulinomas: A Systematic Review and Meta-analysis.

Academic radiology

Percutaneous radiofrequency ablation of pancreatic insulinoma: A case report and literature review.

Radiology case reports

The American journal of medicine

Case report: Continuous glucose monitoring in insulinoma diagnosis and management.

Cardiovascular diabetology. Endocrinology reports

Diazoxide as a bridging therapy in methadone-induced hypoglycemia- a case report and review of the literature.

Surgical Strategies for Tumors of the Pancreas and Duodenum.

Nuklearmedizin. Nuclear medicine

Outcomes of 68Ga-NODAGA-Exendin-4 PET/CT Guided Surgical Management of Insulinomas in MEN1: A Preliminary Study.

I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression.

Diabetologia

Predictors of Transitions From GADA as the Initial Autoantibody to Multiple Autoantibodies of Type 1 Diabetes in Children at Risk by a Dynamic Prediction Model.

Pediatric diabetes

Diagnosis and Surgical Management of Pancreatic Insulinoma in a Non-Diabetic Patient: A Case Report.

Reports (MDPI)

Endocrinology, diabetes & metabolism case reports

Does X mark the spot? A case series of discrepant preoperative insulinoma localization.

Pediatric surgery international

Postoperative complications following surgery for congenital hyperinsulinism and insulinomas in pediatric patients.

Diagnostics (Basel, Switzerland)

Diagnosis and Management of Functional Pancreatic Neuroendocrine Tumors in Children-A Systematic Review.

Annals of surgical oncology

Illuminating the Uncinate: Advanced Indocyanine Green Fluorescence and Ultrasound-Guided Robotic Enucleation of a Pancreatic Insulinoma in a Challenging Position.

Human Polyomavirus BK Genome Analysis in BKPyV Induced Rodent Cell Lines.

MicrobiologyOpen

Analysis of islet antigen-specific autoreactive T cells from Japanese patients with slowly progressive insulin-dependent diabetes mellitus.

Immunology letters

Mi-Lnc70 Regulates the Progression of Murine Pancreatic β-Cell Line and Affects the Synthesis of Insulin and Glucagon.

OncoTargets and therapy

Enucleation for insulinoma: consolidating evidence through systematic review and meta-analysis.

Surgical endoscopy

Allen Oldfather Whipple (1881-1963): A Pioneer of General Surgery.

Journal of the American Animal Hospital Association

Anatomical Preservation of Pancreatic Ducts in Partial Pancreatectomy: A Case Report of Canine Insulinoma.

Anti-tumor potential of combinatory GSK3 inhibition in human 3D models of pancreatic neuroendocrine tumors and patient-derived GEP-NET primary cultures.

Diabetes, Celiac, and Thyroid-Related Autoantibodies in HLA Genotyped Ethiopian Children and Adolescents With Type 1 Diabetes: A Cross-Sectional Study.

Pediatric diabetes

European journal of nuclear medicine and molecular imaging

Insulinoma diagnosis and characterization with intratumoral heterogeneity employing [18F]FB(ePEG12)12-exendin-4 PET/MRI.

International journal of molecular sciences

Dual Effect of 4-Methylumbelliferone on INS1E Cells: Enhancing Migration and Glucose-Stimulated Insulin Secretion.

Diagnostic Accuracy of Insulinoma-Associated Protein 1 in Pulmonary Neuroendocrine Carcinomas: A Systematic Review and Meta-Analysis.

Clinical chemistry and laboratory medicine

The current status of serum insulin measurements and the need for standardization.

RNA binding protein HuD regulates fatty acid oxidation in pancreatic β-cells by modulating long-chain acyl-CoA dehydrogenase expression.

Animal cells and systems

Journal of pediatric endocrinology & metabolism : JPEM

Rare pediatric insulinoma case diagnosed by endoscopic ultrasonography: insights into endogenous hyperinsulinemic hypoglycemia.

Anesthetic Management of a Patient With Suspected Insulinoma Undergoing Cardiopulmonary Bypass for Left Atrial Myxoma: A Case Report.

A&A practice

Recurrent Hypoglycemia in a Non-diabetic: A Case of Suspected Insulinoma Lost to Follow-Up.

European journal of endocrinology

Exenatide for diagnosing endogenous hyperinsulinemic hypoglycemia: a randomized placebo-controlled, double-blind, cross-over proof-of-principle study.

UNVEILING LADA: PREVALENCE AND CHARACTERISTICS AMONG TYPE 2 DIABETIC PATIENTS IN PORT SUDAN, SUDAN.

Georgian medical news

Unlocking the Bioactivity of Sweet Wormwood (Artemisia annua L., Asteraceae) Ethanolic Extract: Phenolics, Antioxidants, and Cytotoxic Effects.

Pharmaceutics

The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release.

Molecular pharmacology

Health information management : journal of the Health Information Management Association of Australia

Optimising insulinoma detection: Algorithm development and validation in a hospital discharge abstract database in China.

Endocrine oncology (Bristol, England)

Unmasking insulinoma following commencement of somatostatin analogues in malignant neuroendocrine tumours.

Chenodeoxycholic acid activates the TGR5/TRPA1-5-HT pathway to regulate intestinal motility in breastfed infants and mouse models.

Translational pediatrics

The Canadian veterinary journal = La revue veterinaire canadienne

Dexmedetomidine constant-rate infusion with additional partial intravenous anesthesia for a dog undergoing partial pancreatectomy for an insulinoma.

Novel germline likely pathogenic frameshift variant of the MEN1 gene contributes to multiple endocrine neoplasia type 1: a case report with review of literature.

Endocrine journal

Endocrine oncology (Bristol, England)

A new link between insulinoma and congenital glucose-galactose malabsorption.

Rapid Onset of Fulminant Type 1 Diabetes 10 Days After the First Dose of Nivolumab: A Case Report.

Clinical and experimental gastroenterology

Clinically Adult-Onset Nesidioblastosis with Repeated Severe Hypoglycemia, Successfully Treated by Two Times Pancreatectomies. A Rare Case Report.

Nutritional Management of Functioning GEP-NENs.

Nutrients

Przeglad gastroenterologiczny

Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) and endoscopic ultrasound-guided ethanol ablation (EUS-EA) of pancreatic neuroendocrine tumors and adenocarcinoma: a prospective multicenter study.

Progenitor neighborhoods function as transient niches to sustain olfactory neurogenesis.

Stem cell reports

Diabetes, obesity & metabolism

Perioperative use and accuracy of continuous glucose monitoring: A systematic review.

Evaluation of Metastatic Insulinoma With Severe Hypoglycemia Using 68 Ga-Exendin-4 PET/CT.

68 Ga-DOTATATE PET/CT-Guided Surgical Resection for Complete Remission of Multifocal Insulinomas in a Father and Son With MEN1 Syndrome.

Prognostic Features in Surgically Resected Well-Differentiated Pancreatic Neuroendocrine Tumors: an Analysis of 904 Patients with 7882 Person-Years of Follow-Up.

Endocrine pathology

Internal medicine (Tokyo, Japan)

Ectopic Insulinoma in the Pyloric Antrum Portion of the Stomach: A Case Report and Review of the Associated Diagnostic Challenges.

World journal of gastrointestinal pathophysiology

Pancreatic neuroendocrine tumors: A case-based evidence review.

Journal of clinical medicine

History of an Insidious Case of Metastatic Insulinoma.

Cancer reports (Hoboken, N.J.)

Rapid Development of Breast Mass With Recurrent Episodes of Hypoglycemia Should Raise Suspicion of Breast Cancer With Insulinoma: A Case Report.

World journal of gastrointestinal endoscopy

Pancreato-hepatobiliary neuroendocrine tumors diagnosed through endoscopic ultrasound: Clinical characteristics and factors associated with high-grade lesions.

Revealing the role of increased SK3 expression in sulfonylurea resistance triggered by prolonged exposure.

Nutrition & diabetes

Current stem cell research & therapy

Muscle-derived Stem Cell Exosomes Enhance Autophagy through the Regulation of the mTOR Signaling Pathway to Attenuate Glucolipotoxicity-induced Pancreatic β-cell Injury.

68 Ga-Exendin-4 PET/CT Enables Identification of Multiple and Ectopic Insulinoma in a Patient With Multiple Endocrine Neoplasia 1.

ACS chemical neuroscience

Modulation of hIAPP Fibrillation by Rationally Designed Hexapeptides Revealed by Molecular Dynamics and Experimental Investigations.

Endocrinology, diabetes & metabolism case reports

A hypoglycaemic 'Peter Pan': a paediatric disease in an adult patient?

Journal of postgraduate medicine

Autoimmune hypoglycemia due to alpha-lipoic acid: Report of two cases.

Atypical Presentation of Insulinoma in a Patient With Hypoglycemia Unawareness: A Case Report.

European journal of pharmacology

Protective role of harmol against β-cell toxicity and glucose dysregulation in type 2 diabetes mellitus.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

Moving Beyond Glycated Hemoglobin to Glucose Patterns: Newer Indications for Continuous Glucose Monitor Use.

Polish archives of internal medicine

Successful treatment of metachronous insulinoma in a patient with multiple endocrine neoplasia type 1 syndrome.

Improved detection and localization of insulinoma using small field-of-view diffusion-weighted MRI: A case report.

Radiology case reports

Bifocal Insulinoma Detected With 68 Ga-Exendin PET/CT and Treated With Endoscopic Ultrasound-guided Radiofrequency Ablation: Toward a Gold-Standard Management?

Six-Year Outcomes Following Stereotactic Body Radiation Therapy for Insulinoma: A Case Report and Literature Review.

Polymerized laminin-modified microcapsules improve pancreatic islet resilience towards cytokine induced inflammatory stress and lower chemoattractant cytokine secretion.

Materials today. Bio

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

Prevalence of Diabetes-related Autoantibodies Among Individuals With Type 2 Diabetes From Primary Care and Endocrinology Community Practice Settings.

Comparative efficacy of systemic therapies in malignant insulinoma.

Environmental science. Processes & impacts

Comparative cytotoxicity and toxicological mechanisms of 6:2 Cl-PFAES and PFOS in pancreatic β cells: implications for glucose metabolism disruption.

Veterinary oncology (London, England)

Single-cell transcriptomic analysis of canine insulinoma reveals distinct sub-populations of insulin-expressing cancer cells.

Veterinary oncology (London, England)

Single-cell transcriptome conservation in a multispecies comparative analysis of fresh and cryopreserved insulinoma cell lines.

The Journal of surgical research

In-Hospital Postoperative Glycemic Trends After Pancreatic Insulinoma Resection.

Peptide receptor radionuclide therapy in malignant insulinoma.

Journal of surgical case reports

Recurrence of malignant insulinoma in the context of multiple endocrine neoplasia type 1: a case report.

Case Report: A case of occult insulinoma localized by [18F] FB (ePEG12)12-exendin-4 positron emission tomography with negative findings of selective arterial calcium stimulation test.

Journal of diabetes investigation

Uhrf1 downregulation promotes β-cell dedifferentiation by decreasing Foxo1 expression in type 2 diabetes.

Medically Refractory Nesidioblastosis as a Late Adverse Effect of Roux-en-Y Gastric Bypass.

The Journal of clinical endocrinology and metabolism

Qualitative and Quantitative Analyses of Noninvasive Diagnosis of Insulinoma Using [18F]FB(ePEG12)12-Exendin-4 PET/CT.

TEAD switches interacting partners along neural progenitor lineage progression to execute distinct functions.

Genes & development

The Journal of clinical endocrinology and metabolism

Localization of Benign Insulinomas With a Radionuclide Tracer Targeting the GLP-1 Receptor With Pegylated Exendin-4.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

Pancreatic neuroendocrine tumors - going beyond surgery. Literature review and experience of a tertiary center.

Case Report: Diazoxide-induced diabetic ketoacidosis in a patient with insulinoma.

American journal of surgery

Pancreatic neuroendocrine tumors: Do we need more nuanced staging?

Expression of insulinoma-associated protein 1 (INSM1) in gastric neuroendocrine and non-neuroendocrine neoplasms.

Discover oncology

Hormones (Athens, Greece)

Association of type 1 stiff-person syndrome and insulinoma: a case report and narrative review.

Aldolase-regulated G3BP1/2+ condensates control insulin mRNA storage in beta cells.

The EMBO journal

International journal of surgical pathology

Gastrointestinal Amphicrine Carcinoma: A Clinicopathologic Study of Five Patients.

Annals of medicine and surgery (2012)

Nesidioblastosis post-bariatric surgery in an adult patient: a case report and review of literature.

Undiagnosed Insulinoma in a Young Patient With Idiopathic Dilated Cardiomyopathy: A Case Report.

Journal of medical case reports

Insulin autoimmune syndrome in a patient with vitiligo: a case report and review of literature.

European journal of nuclear medicine and molecular imaging

Glucagon-like peptide-1 receptor PET/CT with 68Ga-exendin-4 for localizing insulinoma: a real-world, single-center study.

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

Mechanosensitive Channels Mediate Pancreatic β Cells Reactive Oxygen Species Formation and Downregulation of Essential Genes During Therapeutic Ultrasound Treatment.

Slowly Progressive Type 1 Diabetes following Steroid-Sensitive Relapsing Nephrotic Syndrome in Childhood: A Case Report.

Biomedicine hub

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

Impact of the Addition of Beta-Hydroxybutyrate in the 72-Hour Fast Protocol on Hospitalization Duration: A Quality Improvement Report.

Virchows Archiv : an international journal of pathology

GLP- 1R status using validated monoclonal antibody in 689 cases of neuroendocrine neoplasm and its correlation with somatostatin receptor scintigraphy, insulin production, and histological grades.

Multicenter Study on the Clinical Characteristics, Diagnosis, and Treatment Outcomes of Insulinoma: Insights From 15 Medical Centres.

Clinical endocrinology

Temporal Effects of a Viral Peptide on Glucose-Stimulated Insulin Secretion.

ACS infectious diseases

European journal of nuclear medicine and molecular imaging

Comparison of PET/CT using 68Ga-NOTA-Exendin-4 with 68Ga-DOTATATE, 18F-FDG, and conventional imaging in the localization of insulinomas.

Insulin Autoimmune Syndrome: Imaging Findings and Uptake Pattern With 68 Ga-Exendin-4 and 68 Ga-DOTATATE PET-CT.

The American journal of case reports

Diagnostic and Surgical Management of Nesidioblastosis in a 42-Year-Old Man with Refractory Hypoglycemia.

Veterinary and comparative oncology

Evaluation of Serum Level of Chemokine (C-C Motif) Ligand 2 (CCL2) in Canine Urothelial Carcinomas, Mast Cell Tumours, and Insulinomas, and Its Correlation With Circulating Monocytes.

Identification of a Selective Pharmacologic IRE1/XBP1s Activator with Enhanced Tissue Exposure.

ACS chemical biology