Raras
Buscar doenças, sintomas, genes...
Malformação renal ou do trato urinário
ORPHA:93545DOENÇA RARA

Uma doença do sistema urinário caracterizada por defeitos de formação nos rins e/ou nas vias urinárias, que inclui refluxo vesicoureteral.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

Uma doença do sistema urinário caracterizada por defeitos de formação nos rins e/ou nas vias urinárias, que inclui refluxo vesicoureteral.

🏥
SUS: Cobertura mínimaScore: 20%
Centros em: PA, PE, BA, CE, PB +10
Você se identifica com essa condição?
O Raras está aqui pra te apoiar — com ou sem diagnóstico

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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🫘
Rins
7 sintomas
🦴
Ossos e articulações
2 sintomas

+ 6 sintomas em outras categorias

Características mais comuns

Insuficiência renal
Hipoplasia renal
Dor no flanco
Hidronefrose
Hidroureter
Rins hiperecogênicos
15sintomas
Sem dados (15)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 15 características clínicas mais associadas, ordenadas por frequência.

Insuficiência renalRenal insufficiency
Hipoplasia renalRenal hypoplasia
Dor no flancoFlank pain
HidronefroseHydronephrosis
HidroureterHydroureter

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1
Últimos 10 anos200publicações
Pico2026199 papers
Linha do tempo
2025Hoje · 2026🧪 1997Primeiro ensaio clínico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

Genes associados

3 genes identificados com associação a esta condição.

DSTYKDual serine/threonine and tyrosine protein kinaseDisease-causing germline mutation(s) inAltamente restrito
FUNÇÃO

Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540)

LOCALIZAÇÃO

CytoplasmCell membraneApical cell membraneBasolateral cell membraneCell junction

MECANISMO DE DOENÇA

Congenital anomalies of the kidney and urinary tract 1

A disorder encompassing a broad spectrum of renal and urinary tract malformations that include renal agenesis, kidney hypodysplasia, multicystic kidney dysplasia, duplex collecting system, posterior urethral valves and ureter abnormalities. Congenital anomalies of kidney and urinary tract are the commonest cause of chronic kidney disease in children.

EXPRESSÃO TECIDUAL(Ubíquo)
Cérebro - Hemisfério cerebelar
33.1 TPM
Cerebelo
25.4 TPM
Útero
16.7 TPM
Brain Frontal Cortex BA9
15.5 TPM
Ovário
14.8 TPM
OUTRAS DOENÇAS (3)
congenital anomalies of kidney and urinary tract 1hereditary spastic paraplegia 23renal agenesis, unilateral
HGNC:29043UniProt:Q6XUX3
TBX18T-box transcription factor TBX18Disease-causing germline mutation(s) inRestrito
FUNÇÃO

Acts as a transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart and coronary vessels, the ureter and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area

LOCALIZAÇÃO

Nucleus

MECANISMO DE DOENÇA

Congenital anomalies of kidney and urinary tract 2

A disorder encompassing a broad spectrum of renal and urinary tract malformations that include renal agenesis, kidney hypodysplasia, multicystic kidney dysplasia, duplex collecting system, posterior urethral valves and ureter abnormalities. Congenital anomalies of kidney and urinary tract are the commonest cause of chronic kidney disease in children.

EXPRESSÃO TECIDUAL(Tecido-específico)
Artéria tibial
46.7 TPM
Artéria coronária
36.0 TPM
Fibroblastos
26.6 TPM
Aorta
25.3 TPM
Nervo tibial
19.2 TPM
OUTRAS DOENÇAS (1)
congenital anomalies of kidney and urinary tract 2
HGNC:HGNC:11595UniProt:O95935
NRIP1Nuclear receptor-interacting protein 1Disease-causing germline mutation(s) inAltamente restrito
FUNÇÃO

Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549)

LOCALIZAÇÃO

Nucleus

VIAS BIOLÓGICAS (7)
Expression of BMAL (ARNTL), CLOCK, and NPAS2RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionHeme signalingSUMOylation of transcription cofactorsEstrogen-dependent gene expression
MECANISMO DE DOENÇA

Congenital anomalies of kidney and urinary tract 3

A disorder encompassing a broad spectrum of renal and urinary tract malformations that include renal agenesis, kidney hypodysplasia, multicystic kidney dysplasia, duplex collecting system, posterior urethral valves and ureter abnormalities. Congenital anomalies of kidney and urinary tract are the commonest cause of chronic kidney disease in children. CAKUT3 inheritance is autosomal dominant.

EXPRESSÃO TECIDUAL(Ubíquo)
Cervix Endocervix
21.0 TPM
Tecido adiposo
19.7 TPM
Cervix Ectocervix
17.5 TPM
Mama
16.8 TPM
Fibroblastos
16.3 TPM
OUTRAS DOENÇAS (1)
congenital anomalies of kidney and urinary tract 3
HGNC:HGNC:8001UniProt:P48552

Medicamentos aprovados (FDA)

2 medicamentos encontrados nos registros da FDA americana.

💊 DEFITELIO (DEFIBROTIDE SODIUM)
💊 MultiHance (GADOBENATE DIMEGLUMINE)
Ver no DailyMed/FDA

Variantes genéticas (ClinVar)

194 variantes patogênicas registradas no ClinVar.

🧬 NRIP1: NM_003489.4(NRIP1):c.3203T>C (p.Leu1068Pro) ()
🧬 NRIP1: GRCh38/hg38 21q11.2-22.3(chr21:13644166-44968483)x3 ()
🧬 NRIP1: GRCh37/hg19 21q11.2-22.11(chr21:15023402-32738832)x3 ()
🧬 NRIP1: GRCh37/hg19 21q11.2-21.3(chr21:15520684-30322198)x3 ()
🧬 NRIP1: NM_003489.4(NRIP1):c.2791A>T (p.Lys931Ter) ()
Ver todas no ClinVar

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

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Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
2Fase 23
1Fase 12
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 5 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Malformação renal ou do trato urinário

Centros de Referência SUS

24 centros habilitados pelo SUS para Malformação renal ou do trato urinário

Centros para Malformação renal ou do trato urinário

Detalhes dos centros

Hospital Universitário Prof. Edgard Santos (HUPES)

R. Dr. Augusto Viana, s/n - Canela, Salvador - BA, 40110-060 · CNES 0003808

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do Metabolismo

Hospital Infantil Albert Sabin

R. Tertuliano Sales, 544 - Vila União, Fortaleza - CE, 60410-794 · CNES 2407876

Serviço de Referência

Rota
Anomalias CongênitasDeficiência Intelectual

Hospital de Apoio de Brasília (HAB)

AENW 3 Lote A Setor Noroeste - Plano Piloto, Brasília - DF, 70684-831 · CNES 0010456

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital Estadual Infantil e Maternidade Alzir Bernardino Alves (HIABA)

Av. Min. Salgado Filho, 918 - Soteco, Vila Velha - ES, 29106-010 · CNES 6631207

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital das Clínicas da UFG

Rua 235 QD. 68 Lote Área, Nº 285, s/nº - Setor Leste Universitário, Goiânia - GO, 74605-050 · CNES 2338424

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do Metabolismo

Hospital Universitário da UFJF

R. Catulo Breviglieri, Bairro - s/n - Santa Catarina, Juiz de Fora - MG, 36036-110 · CNES 2297442

Atenção Especializada

Rota
Anomalias Congênitas

Hospital das Clínicas da UFMG

Av. Prof. Alfredo Balena, 110 - Santa Efigênia, Belo Horizonte - MG, 30130-100 · CNES 2280167

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital Universitário Julio Müller (HUJM)

R. Luis Philippe Pereira Leite, s/n - Alvorada, Cuiabá - MT, 78048-902 · CNES 2726092

Atenção Especializada

Rota
Anomalias Congênitas

Hospital Universitário João de Barros Barreto

R. dos Mundurucus, 4487 - Guamá, Belém - PA, 66073-000 · CNES 2337878

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital Universitário Lauro Wanderley (HULW)

R. Tabeliao Estanislau Eloy, 585 - Castelo Branco, João Pessoa - PB, 58050-585 · CNES 0002470

Atenção Especializada

Rota
Anomalias Congênitas

Instituto de Medicina Integral Prof. Fernando Figueira (IMIP)

R. dos Coelhos, 300 - Boa Vista, Recife - PE, 50070-902 · CNES 0000647

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital Pequeno Príncipe

R. Des. Motta, 1070 - Água Verde, Curitiba - PR, 80250-060 · CNES 3143805

Serviço de Referência

Rota
Anomalias CongênitasDeficiência Intelectual

Hospital Universitário Regional de Maringá (HUM)

Av. Mandacaru, 1590 - Parque das Laranjeiras, Maringá - PR, 87083-240 · CNES 2216108

Atenção Especializada

Rota
Anomalias Congênitas

Hospital de Clínicas da UFPR

R. Gen. Carneiro, 181 - Alto da Glória, Curitiba - PR, 80060-900 · CNES 2364980

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital Universitário Pedro Ernesto (HUPE-UERJ)

Blvd. 28 de Setembro, 77 - Vila Isabel, Rio de Janeiro - RJ, 20551-030 · CNES 2280221

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do Metabolismo

Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira (IFF/Fiocruz)

Av. Rui Barbosa, 716 - Flamengo, Rio de Janeiro - RJ, 22250-020 · CNES 2269988

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital São Lucas da PUCRS

Av. Ipiranga, 6690 - Jardim Botânico, Porto Alegre - RS, 90610-000 · CNES 2232928

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do Metabolismo

Hospital de Clínicas de Porto Alegre (HCPA)

Rua Ramiro Barcelos, 2350 Bloco A - Av. Protásio Alves, 211 - Bloco B e C - Santa Cecília, Porto Alegre - RS, 90035-903 · CNES 2237601

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital Universitário da UFSC (HU-UFSC)

R. Profa. Maria Flora Pausewang - Trindade, Florianópolis - SC, 88036-800 · CNES 2560356

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do Metabolismo

Hospital das Clínicas da FMUSP

R. Dr. Ovídio Pires de Campos, 225 - Cerqueira César, São Paulo - SP, 05403-010 · CNES 2077485

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital de Base de São José do Rio Preto

Av. Brg. Faria Lima, 5544 - Vila Sao Jose, São José do Rio Preto - SP, 15090-000 · CNES 2079798

Atenção Especializada

Rota
Anomalias Congênitas

Hospital de Clínicas da UNICAMP

R. Vital Brasil, 251 - Cidade Universitária, Campinas - SP, 13083-888 · CNES 2748223

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital de Clínicas de Ribeirão Preto (HCRP-USP)

R. Ten. Catão Roxo, 3900 - Vila Monte Alegre, Ribeirão Preto - SP, 14015-010 · CNES 2082187

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

UNIFESP / Hospital São Paulo

R. Napoleão de Barros, 715 - Vila Clementino, São Paulo - SP, 04024-002 · CNES 2688689

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do Metabolismo
Sobre os centros SUS: Estes centros são habilitados pelo Ministério da Saúde como Serviços de Referência em Doenças Raras ou Serviços de Atenção Especializada. O atendimento é pelo SUS, com encaminhamento da rede de atenção básica.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

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Publicações mais relevantes

Timeline de publicações
0 papers (10 anos)
#1

Atherosclerosis in chronic kidney disease-early prevention is better than late treatment.

Kidney international2027 Dec 05
#2

DR5/WDR12 balances p65 stability promoting sunitinib resistance in renal cell carcinoma.

Cell death and differentiation2026 Mar 23

A resistência ao sunitinibe, um tratamento crucial para o carcinoma de células renais claras (ccRCC), é um desafio significativo. Este estudo revela que a proteína DR5 está elevada em tumores resistentes e pacientes com pior resposta à terapia, promovendo essa resistência ao estabilizar uma via celular específica. Crucialmente, o bloqueio da DR5 e de sua via de sinalização associada (DR5/NF-κB/BCL2) mostrou-se capaz de restaurar a sensibilidade ao sunitinibe, sugerindo uma nova e promissora estratégia terapêutica para superar a resistência em pacientes com ccRCC.

🇧🇷 traduzido
#3

IFI16 is essential to linking DNA damage and ferroptosis in acute kidney injury.

Cell death & disease2026 Mar 23

Este estudo revelou que a proteína IFI16 desempenha um papel crucial na lesão renal aguda (LRA), atuando como um elo entre o dano ao DNA e a ferroptose, um tipo de morte celular que contribui para a doença. Foi observado que os níveis de IFI16 estão elevados em pacientes com LRA e que sua inibição reduz significativamente a morte das células renais por ferroptose. Assim, para pacientes e médicos, ter como alvo a IFI16 pode representar uma nova e promissora estratégia terapêutica para tratar a LRA.

🇧🇷 traduzido
#4

SP/NK-1 pathogenic signaling drives doxorubicin nephrotoxicity: Novel therapeutic role of MK-0869 via modulation of α-Klotho, RAS, and Wnt/β-catenin trajectories.

Life sciences2026 Mar 21

A quimioterapia com doxorrubicina, embora vital, é limitada pela nefrotoxicidade renal severa. Este estudo identifica o MK-0869 como um promissor agente para combater esse dano. Em testes com ratos, o MK-0869 protegeu significativamente contra a lesão renal induzida por doxorrubicina, melhorando a função (com uma redução de 53% na creatinina) e a arquitetura do rim, ao modular vias como α-Klotho, o sistema renina-angiotensina e o estresse oxidativo. Isso sugere que o MK-0869 tem potencial como adjunto renoprotetor na terapia com doxorrubicina, justificando estudos futuros para sua aplicação clínica em pacientes.

🇧🇷 traduzido
#5

The m5C orchestrator NSUN7 drives SPARC/HMGB1 axis-mediated inflammation to exacerbate kidney injury.

Proceedings of the National Academy of Sciences of the United States of America2026 Mar 31

Este estudo identifica a proteína NSUN7 como um importante impulsionador da inflamação renal em doenças como a lesão renal aguda (LRA), agravando-a ao regular modificações de RNA e a proteína SPARC, o que promove a infiltração de células imunes prejudiciais. Pesquisadores demonstraram que o silenciamento terapêutico da NSUN7 em modelos pré-clínicos reduziu a inflamação e melhorou os resultados renais, posicionando-a como um novo e promissor alvo para o desenvolvimento de tratamentos para doenças renais inflamatórias.

🇧🇷 traduzido

Publicações recentes

📚 EuropePMCmostrando 197

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Acute kidney injury after major hepatectomy: association with postoperative complications and post-hepatectomy liver failure.

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Pulmonary Metastases From Undiagnosed Prostate Cancer Mimicking Late Recurrence of Renal Cell Carcinoma: Diagnosis Confirmed by Thoracoscopic Biopsy.

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[Contrast-induced acute kidney injury after prostatic artery embolization].

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The Protective Effect of Vitamin C Targeting Oxidative Stress on Renal Function in Patients with Septic Acute Kidney Injury: A Prospective, Randomized Controlled, Pilot Study.

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Investigation of Antitumor Activity of Modified Citrus Pectin: Oral and Intravenous Administration Assessed via Molecular Imaging.

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Social isolation and 59 common health conditions: insights from observational and genetics analyses.

BMC medicine
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Predictors of chronic kidney diseases and kidney failure in patients with CAKUT: a cohort study.

International urology and nephrology
2026

SETD2 methyltransferase activity promotes correct transcription initiation and termination.

EMBO reports
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DR5/WDR12 balances p65 stability promoting sunitinib resistance in renal cell carcinoma.

Cell death and differentiation
2026

Development of metabolic syndrome by increasingly fructose-enriched water in Wistar rats.

Journal of molecular histology
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Risk factors for incidental prostate cancer following surgery for benign prostatic enlargement: A systematic review and meta-analysis.

Prostate cancer and prostatic diseases
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Probiotic Enterococcus faecium (M74) as an alternative to antibiotics for controlling necrotic enteritis in broiler chickens.

Scientific reports
2026

IFI16 is essential to linking DNA damage and ferroptosis in acute kidney injury.

Cell death & disease
2026

Young adults undergoing anterior resection for colorectal cancer experience fewer medical complications but a comparable risk of anastomotic leak.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
2026

Angiotensin Receptor Blockade to Treat Tacrolimus-Associated Hypertension: Is There a Benefit Beyond Blood Pressure Reduction?

Acta physiologica (Oxford, England)
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Urological manifestations in familial mediterranean fever excluding renal amyloidosis: a systematic review.

Rheumatology (Oxford, England)
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Patient-derived organoids in renal cell carcinoma: A review of methodologies and applications.

Urologic oncology
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In Vivo Spatiotemporal Protection and Recognition of Circulating Tumor DNA for Early Cancer Diagnosis and Monitoring.

Journal of the American Chemical Society
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Frailty, socioeconomic factors, and nutritional biomarkers in patients with nondialysis chronic kidney disease: A cross-sectional analysis.

The Journal of international medical research
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Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of renal cell carcinoma, version 3.0.

Journal for immunotherapy of cancer
2026

Hemodynamic coherence in 2025: A year in review from the Fluid Therapy and Hemodynamic Group of the Spanish Society of Anesthesiology, Reanimation and Pain Therapy (SEDAR).

Revista espanola de anestesiologia y reanimacion
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Dipicolinic acid (DPA)-based chelators for zirconium-89 PET imaging applications.

Bioorganic & medicinal chemistry letters
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Health status and effects of spironolactone in people at high risk of heart failure: the Heart OMics in AGEinging (HOMAGE) randomized trial.

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology
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Management of lipid profile and lipid-lowering therapy in the diabetic population of a primary care center according to cardiovascular risk category (SCORE2-Diabetes vs. SCORE).

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology
2026

SP/NK-1 pathogenic signaling drives doxorubicin nephrotoxicity: Novel therapeutic role of MK-0869 via modulation of α-Klotho, RAS, and Wnt/β-catenin trajectories.

Life sciences
2026

VACTERL Association in Screened Patients with Esophageal Atresia: A Retrospective Cohort Study.

Journal of pediatric surgery
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[Genetic kidney diseases].

Deutsche medizinische Wochenschrift (1946)
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The role of spinal stereotactic radiosurgery in the treatment of renal cell carcinoma spinal metastases.

Journal of neurosurgery. Spine
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Hematuria as a biomarker guiding treatment decisions in IgA nephropathy? no.

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Nutritional paradoxes of the new Dietary Guidelines for Americans (2025-2030): a critical analysis.

Jornal brasileiro de nefrologia
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ENDOTHELIUM-DERIVED ENDOTHELIN-1 MEDIATES SICKLE CELL NEPHROPATHY.

Function (Oxford, England)
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The m5C orchestrator NSUN7 drives SPARC/HMGB1 axis-mediated inflammation to exacerbate kidney injury.

Proceedings of the National Academy of Sciences of the United States of America
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Microhardness Variation in Calcium Oxalate Monohydrate Stones: A Potential Explanation for Fragment Formation During Laser Dusting.

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Ternary Heterojunction-Reinforced Room-Temperature Flexible NH3 Sensor with Enhanced Sensitivity and Ultralow Detection Limit.

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Somatic mutational landscape in von Hippel-Lindau familial hemangioblastoma.

Molecular oncology
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Kinetics of cellular immune response to SARS-CoV-2 vaccine boosters in dialysis and kidney transplant patients without infection.

Jornal brasileiro de nefrologia
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Oral Glucagon-Like Peptide-1 Receptor Agonists for Preventing Cardiorenal Complications.

Current cardiology reports
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Observation on the short-term efficacy of telitacicept in the treatment of primary IgA nephropathy.

International urology and nephrology
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Silent complexity: a rare combination of polysplenia, cleft palate, retroaortic renal vein, and dorsal pancreatic agenesis.

Pediatric radiology
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The time has come for optimizing beta-lactam therapy in critically ill patients with renal dysfunction.

Intensive care medicine
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Diagnosis and Management of Resistant Hypertension: A Review.

JAMA
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American journal of hematology
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Villous Adenoma of the Renal Pelvis: Clinicopathologic Spectrum and Diagnostic Considerations.

International journal of surgical pathology
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The Uric Acid Degrading Probiotics MC1 in Quercetin Nanocoatings and Bioactive Polysaccharides Microgels for Anti-Hyperuricemia and Gut Microenvironment Modulation.

Advanced healthcare materials
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Omental band induced bowel ischemia following combination immunotherapy in a patient with renal cell cancer.

Irish medical journal
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Association between pre-existing heart failure and in-hospital outcomes and management in admissions with cardiogenic shock.

Expert review of cardiovascular therapy
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Ovarian Hormones Moderate Systolic Hypertension in Female Eln Haploinsufficient Mice.

American journal of physiology. Renal physiology
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Family caregiver-assisted peritoneal dialysis in Argentina: A multicenter descriptive study.

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis
2026

Deceased Organ Donation and Transplantation in LIMC: A Meeting Report.

Transplantation
2026

A More Precise Description of the AKT2-Related Hypoinsulinemic Hypoglycemia and Overgrowth Syndrome Phenotype, Formerly Described Under the MORFAN Acronym.

American journal of medical genetics. Part A
2026

Extracellular vesicle miR-93-5p cargo regulates glomerular endothelial cell damage in Alport syndrome.

JCI insight
2026

Combined single-cell transcriptome and immune repertoire analysis reveals hepatic and renal immune injury by heat stroke.

JCI insight
2026

Combined melatonin and curcumin treatment ameliorates renal ischemia-reperfusion injury via reducing oxidative stress, inflammation, and apoptosis in rats.

Biotechnic & histochemistry : official publication of the Biological Stain Commission
2026

Rare renal tumor: a case report of collecting duct carcinoma and literature review.

Frontiers in oncology
2026

A case report of extra-adrenal retroperitoneal myelolipoma.

Frontiers in oncology
2026

Prevalence and influencing factors of malnutrition in maintenance hemodialysis patients in China: a systematic review.

Frontiers in public health
2026

Clinical research progress of renal denervation for heart failure treatment: current evidence, controversies, and future directions.

Frontiers in cardiovascular medicine
2026

Management strategies for giant renal artery aneurysms: a systematic review and case report.

American journal of clinical and experimental immunology
2026

Renal macrophage TLR7 signaling in lupus nephritis: from pathogenic mechanisms to therapeutic opportunities.

Frontiers in immunology
2026

Targeting the oxidative stress-neuroinflammation axis: the mechanism of arctigenin's broad-spectrum analgesia with limited side effects.

Frontiers in immunology
2026

Long-term outcomes in primary membranous nephropathy: a Chinese cohort study with novel target antigen.

Frontiers in immunology
2026

The Critical Care Phenotype of Hypokalemic Paralysis: Etiology, Outcomes, and Predictors of Respiratory Failure in a Retrospective Cohort Study.

Cureus
2026

Comparison of Adverse Events Associated With Six Common Antibiotics in Lower Respiratory Tract Infections Using the United States Food and Drug Administration Adverse Event Reporting System.

Cureus
2026

Spinal Anesthesia in a Respiratory-Compromised Patient With Fabry Disease Undergoing Umbilical Hernia Repair: A Case Report.

Cureus
2026

Brown Tumor in a Patient With End-Stage Renal Disease: A Case Report of Secondary Hyperparathyroidism Complications.

Cureus
2026

A Life-Threatening Metastasis of Renal Cell Carcinoma: An Endotracheal Metastasis.

Cureus
2026

Right Ventricular Thrombus Presenting With Right Ventricular Failure in Septic Shock: A Case Report.

Cureus
2026

Renal Tubular Acidosis Leading to Severe Hypokalemia: An Uncommon Adverse Effect of Nonsteroidal Anti-inflammatory Drugs.

Cureus
2026

Preoperative Angiotensin-Converting Enzyme Inhibitor Use and Its Effect on Intraoperative Hypotension in Non-cardiac Surgeries: A Meta-Analysis.

Cureus
2026

Role of Enhanced Recovery After Surgery (ERAS) Protocols in Preventing Postoperative Acute Kidney Injury (AKI).

Cureus
2026

Prevalence of Hypoxic Ischemic Encephalopathy and Multiorgan Dysfunction in Late Preterm and Term Infants Receiving Resuscitation Beyond Initial Steps at Birth.

Cureus
2026

Extracapillary Proliferation Superimposed on Primary Membranous Glomerulonephritis: A Case Report.

Cureus
2026

Hidden in Hydronephrosis: Mixed Epithelial and Stromal Tumor of the Kidney (MESTK) Mimicking Hydronephrosis.

Cureus
2026

Acute Boric Acid Poisoning With Chronic Renal Failure Successfully Treated With Continuous Hemofiltration.

Cureus
2026

Development and validation of a multivariable prediction model for non-invasive discrimination between diabetic and non-diabetic kidney disease in type 2 diabetes: a clinical nomogram.

Frontiers in endocrinology
2026

Lineage-Specific Disruption of Hematopoiesis by Oxaliplatin: Mechanisms of Erythropoietin Resistance and Immune Suppression.

Journal of hematology and oncology research
2026

Electro-acupuncture attenuates cyclophosphamide-induced premature ovarian insufficiency in rats through miRNA regulation and TGFβ/Smad pathway modulation.

American journal of translational research
2026

Specialized nursing improves clinical outcomes in pediatric AKI patients undergoing CRRT: a retrospective cohort study.

American journal of translational research
2026

Propofol decreases the resistance of neutrophils to Candida albicans by inhibiting ferroptosis and the cGAS-STING pathway.

American journal of translational research
2026

Efficacy of rhBNP in heart failure with atrial fibrillation combined with poor conventional therapy response and recurrence risk factors.

American journal of translational research
2026

Gamified renal point-of-care ultrasound to promote recruitment and anatomical competence in nephrology.

Clinical kidney journal
2026

Development and validation of early-stage and progression prediction models for chronic kidney disease: a retrospective study.

PeerJ
2026

Pressure cycling technology-assisted data-independent acquisition proteomics reveals molecular alterations and potential therapeutic targets in minor glomerular abnormalities.

Precision clinical medicine
2026

Major Adverse Limb Events and Death After Successful Endovascular Revascularization: BEST-CLI Trial.

Journal of the Society for Cardiovascular Angiography & Interventions
2026

Enhancing Percutaneous Access: The «GENOA» Prone Modified Position.

Research and reports in urology
2026

Identification of risk factors for the development and prognosis of bone metastases in renal cell carcinoma: development and validation of a predictive model.

American journal of cancer research
2026

Physiologic Markers of Mortality in Acute Valve Syndrome: An Ischemic Physiology Score Stratifies Patient Risk.

Structural heart : the journal of the Heart Team
2026

Global renal infarction from main renal artery occlusion in under-anticoagulated atrial fibrillation: A case report.

Radiology case reports
2026

Pelvic pain and a missing kidney: Unveiling OHVIRA syndrome with a tubo-ovarian abscess.

Radiology case reports
2026

Metastatic renal cell carcinoma to the thyroid gland with tracheal invasion: A case report.

Radiology case reports
2026

Beyond the 30-day metric: National trends and predictors of 90-day readmission after coronary artery bypass grafting.

American heart journal plus : cardiology research and practice
2026

Prospective Evaluation of Postoperative SIRS and Serum Inflammatory Indices in Percutaneous Nephrolithotomy Patients.

Therapeutics and clinical risk management
2026

Complex interactions of gut-derived short-chain fatty acids in hyperuricemia and gout pathophysiology.

Frontiers in microbiology
2026

Synthesis of [18F]rufinamide as a radiotracer for epileptic brain imaging.

RSC advances
2026

Diagnosis of early kidney allograft rejection: influencing factors in metabolite-based urine analysis.

Frontiers in medicine
2026

Nursing interventions and multidomain physiological trajectories in ARDS: a retrospective cohort study.

Frontiers in medicine
2026

Precision targeting of gut-kidney axis: mucosal immunomodulation in IgA nephropathy-a perspective.

Frontiers in medicine
2026

Role of Sodium-Glucose Transport Protein-2 Inhibitors in Renal Protection: A Narrative Review from the Cardiovascular-Kidney-Metabolic Interconnection.

Drug design, development and therapy
2026

Combined ACEI and ARB therapy and ICU mortality in critically ill COVID-19 patients: a retrospective cohort study.

Frontiers in pharmacology
2026

Endoscopic removal of fungal balls using an access sheath and bendable suction device during URS: A novel approach.

Urology case reports
2026

Clinical, laboratory, and histopathological characteristics of pediatric lupus nephritis: a retrospective study in a national referral center in Mexico.

Frontiers in pediatrics
2026

Long-term survival and complications of Fontan patients: where do we stand?

American journal of cardiovascular disease
2026

Fine Particulate Matter Exposure and Risk of Major Adverse Cardiac and Cerebrovascular Events (MACCE) in Post-Percutaneous Coronary Intervention (PCI) Patients: A Thai PCI Registry-Based Cohort Study.

Global heart
2026

Treatment of glomerular and tubular proteinuria in the nephrotic range in a female cat: case report.

Brazilian journal of veterinary medicine
2026

Circadian Dysregulation in Aging Alters Senescence and Inflammatory Pathways in a Sex- and Time-of-Day-Dependent Manner.

bioRxiv : the preprint server for biology
2026

Association of Ambulatory Arterial Pressure Index with Circadian Blood Pressure Patterns in Patients with Primary Hypertension and Coronary Artery Disease.

International journal of general medicine
2026

Cerebral Neurodegeneration and Cognitive Impairment in Patients on Maintenance Hemodialysis: the Role of Neuroglia and Associated Factors (Review).

Sovremennye tekhnologii v meditsine
2026

Peri-implantitis: a systemic burden for our patients.

Frontiers in dental medicine
2026

Functional Effects of Cyclization on Li1 Peptide Activity against Metacyclic Leishmania amazonensis Internalization.

ACS omega
2026

A non-invasive predictive model for identifying non-diabetic kidney disease in type 2 diabetes mellitus: development and multicenter validation.

American journal of clinical and experimental urology
2026

Makorin Ring Finger Protein 1 Inhibits Cell Proliferation in Renal Angiomyolipoma via the ERK/MAPK Signaling Pathway.

Kidney diseases (Basel, Switzerland)
2026

CYBB-Mediated Ferroptosis Drives Podocyte Injury in Lupus Nephritis and Represents a Therapeutic Target.

Journal of inflammation research
2026

Nafamostat Mesilate as an Anticoagulation Strategy for Heparin-Induced Thrombocytopenia: A Case Report.

Journal of blood medicine
2026

Biomonitoring and toxicological assessment of Ochratoxin A and Citrinin in a sex-gender perspective: The OTABioTox Project.

Annali dell'Istituto superiore di sanita
2026

Case Report: Spontaneous Tumor Lysis Syndrome in a Patient With Cholangiocarcinoma.

Journal of investigative medicine high impact case reports
2026

Reduction of hemorrhagic complications after non-focal renal biopsy with pre-procedure desmopressin administration.

Diagnostic and interventional radiology (Ankara, Turkey)
2026

Recovery trajectories of TAFRO syndrome: a single-center case series highlighting prolonged thrombocytopenia and anasarca.

Immunological medicine
2026

LUNELORD: A descriptive, prospective study on the demographics, disease characteristics and health-related quality of life of patients with LUpus NEphritis and long-term ORgan damage in rheumatology clinics in the Arabian Gulf.

Lupus
2026

Renal Nonenhancement From Aortocaval Fistula in Abdominal Aortic Aneurysm.

Korean circulation journal
2026

Osteoporosis in chronic kidney disease: diagnostic dilemmas and therapeutic controversies.

Expert review of endocrinology & metabolism
2026

Atrial Fibrillation Ablation Outcomes by Hospital Academic Status.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
2026

Functional characterization of human organic anion transporter 4 (hOAT4) as a pH-dependent citrate transporter in renal proximal tubules.

Journal of pharmacological sciences
2026

Low fruit and vegetable intake in children: a dietary stressor raising renal ammonium and adrenal cortisol secretion.

Pflugers Archiv : European journal of physiology
2026

Comparative pathogenicity of very virulent and novel variant infectious bursal disease virus Egyptian strains in chickens.

Virology journal
2026

An oral nanocombinatorial agent exhibits pleiotropic improvement in diabetic nephropathy via modulation of the SCAP/SREBPs pathway.

Journal of nanobiotechnology
2026

Erythrodermic psoriasis complicated by immune complex-mediated crescentic glomerulonephritis and atypical hemolytic uremic syndrome: a case report.

BMC nephrology
2026

Efficacy and safety of peptide radionuclide therapy with 177Lu-DOTATATE in Japanese patients with advanced neuroendocrine neoplasm: a multicenter retrospective study (JON2203-N).

Journal of gastroenterology
2026

Evaluation of Synthetic PES Membranes for Relative Endotoxin Reduction in Dialysis Water.

Water environment research : a research publication of the Water Environment Federation
2026

Autoantibodies Targeting Complement Regulating Factors Induced C3 Glomerulopathy Resambling C4 Dense Deposit Disease: A Case Report.

Nephrology (Carlton, Vic.)
2026

Emphysematous Pyelonephritis After Embolization of a Nonfunctioning Kidney Graft.

Nephrology (Carlton, Vic.)
2026

Optimization of Ionic Matrix Deposition to Increase the Performance of MALDI-Based Spatial N-Glycomics.

Journal of mass spectrometry : JMS
2026

A double-blind, randomized, placebo-controlled, phase 2 trial examined the efficacy and safety of monlunabant in adults with diabetic kidney disease.

Kidney international
2026

Cancer Therapy and the Kidney.

Kidney international
2026

Unique aspects of the acute kidney injury associated with infections in the tropics: presentation, challenges and opportunities.

Kidney international
2026

Frailty is associated with increased risk for upper arm arteriovenous fistula abandonment.

Journal of vascular surgery
2026

A Comparison of Elective Late Open Surgical Conversion after EVAR versus Primary Open Repair for Abdominal Aortic Aneurysm in a Single High-Volume Center.

Journal of vascular surgery
2026

Intraventricular metastasis: A systematic review of patient demographics, clinical characteristics, and outcomes.

Neuro-Chirurgie
2026

Paid Employment and Ability to Work Among People Receiving Dialysis: A Systematic Review of Qualitative Studies.

American journal of kidney diseases : the official journal of the National Kidney Foundation
2026

Dialysis Facility Closures in the US From 2018 to 2024: A Serial Cross-Sectional Study.

American journal of kidney diseases : the official journal of the National Kidney Foundation
2026

Medicaid Expansion and Optimal Starts of Treatment for Incident Kidney Failure.

American journal of kidney diseases : the official journal of the National Kidney Foundation
2026

Is There a Role for Pentoxifylline in Diabetic Kidney Disease?

American journal of kidney diseases : the official journal of the National Kidney Foundation
2026

Natural History of Tricuspid Regurgitation Following Transcatheter-Edge-to - Edge Repair; Insights from Clinical Trials and Multi-Center Registries.

The Canadian journal of cardiology
2026

ZFP36 and CEBPA are macrophage-associated prognostic biomarkers linked to glomerular endothelial inflammation in ANCA-associated glomerulonephritis.

Experimental cell research
2026

The Impact of Re-operation on Aortic Arch Reconstructive Surgery: Evidence from a Multicentre, National Registry.

The Journal of thoracic and cardiovascular surgery
2026

Corticosteroids for Treating Sepsis: A Systematic Review and Network Meta-analysis.

Respiratory medicine
2026

Socioeconomic deprivation and post-discharge mortality in heart failure: evidence from a nationwide universal health coverage system.

European heart journal. Quality of care & clinical outcomes
2026

SLAMF1 at the crossroads of immunity and disease: Biology, pathology, and therapeutic opportunities.

Cytokine
2026

Asiaticoside attenuates renal fibrosis by targeting STAT3 to restore Th17/Treg homeostasis.

Phytomedicine : international journal of phytotherapy and phytopharmacology
2026

Salvia miltiorrhiza extract attenuates cardiorenal syndrome by inhibiting IL-1β mediated cross-talk between heart and kidney.

Phytomedicine : international journal of phytotherapy and phytopharmacology
2026

Lack of effect of short-term interval training on kidney function in obese adolescent females.

Clinics (Sao Paulo, Brazil)
2026

Pomiferin protects against sepsis-associated acute liver and kidney injury via inhibition of NF-κB activation, oxidative stress, and cytochrome-c.

Scientific reports
2026

Urine microscopy can identify cholemic nephropathy as a distinct form of kidney dysfunction in patients with acute on chronic liver failure.

Scientific reports
2026

Beyond glomeruli: interstitial fibrosis and tubular atrophy predict poor renal outcomes in lupus nephritis.

Arthritis research & therapy
2026

Continuous monitoring of intra-abdominal pressure: cumulative pressure exposure predicts early acute kidney injury in animal model.

World journal of emergency surgery : WJES
2026

A Standardized workflow for Orthohantavirus production, detection, and antiviral screening.

Virology journal
2026

A diagnostic challenge: right-sided infective endocarditis presenting as isolated fatigue in a psychiatric patient.

International journal of emergency medicine
2026

An interpretable machine learning model based on habitat radiomics combined with deep learning for predicting the WHO/ISUP grade of patients with clear cell renal cell carcinoma.

BMC medical imaging
2026

Prevalence and determinants of urinary tract infection among Ethiopian children: a systematic review and meta-analysis of institution-based studies.

BMC infectious diseases
2026

Non-diabetic kidney disease in a patient with type 2 diabetes mellitus: a case report.

BMC nephrology
2026

Experiences of hemodialysis in patients with end-stage renal disease: a patient journey map based on a qualitative study.

BMC nephrology
2026

Heart failure as a leading independent predictor for mortality and adverse outcomes after bariatric surgery: analysis using the 2023-2024 MBSAQIP database.

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
2026

Redo partial or radical nephrectomy for solitary renal recurrence after previous nephron-sparing surgery: Is functional preservation always justified?

Urologic oncology
2026

Monogenic and Polygenic Risk for Kidney Cancer in Two Large Biobanks.

European urology oncology
2026

Prevention of urinary stones with hydration: a randomised clinical trial of an adherence intervention.

Lancet (London, England)
2026

Angiography-derived fractional flow reserve versus coronary angiography to guide coronary artery bypass grafting in patients undergoing surgical valve procedures with concomitant coronary artery disease in China (FAVOR IV-QVAS): a multicentre, triple-blind, randomised trial.

Lancet (London, England)
2026

ALDH1A1 is a potential novel target for treatment of ADPKD.

Kidney international
2026

The Janus face of parathyroid hormone in renal osteodystrophy.

Kidney international
2026

Nobel prize-winning Treg cells in autoimmune kidney diseases and transplantation.

Kidney international
2026

A Young Man With Nephrotic Syndrome and Facial Rash: A Quiz.

American journal of kidney diseases : the official journal of the National Kidney Foundation
2026

Beyond the Individual: Toward a Family-Centered Understanding of Dialysis Caregiving.

American journal of kidney diseases : the official journal of the National Kidney Foundation
2026

Impact of Post-Transplant Cyclophosphamide on the Prognostic Value of HCT-CI.

Transplantation and cellular therapy
2026

AA amyloidosis in inflammatory joint diseases in the era of biological therapies: prevalence, manifestations, management and evolution.

Joint bone spine
2026

Androgen receptor-NOX4-necroptosis axis drives male-biased susceptibility in aristolochic acid-induced acute kidney injury.

Chemico-biological interactions
2026

Mediterranean diet preserves renal mitochondrial homeostasis and attenuates early diabetic kidney injury in db/db mice.

Experimental gerontology
2026

Population Pharmacokinetics and Dosing Regimen Optimization of Ceftazidime in Plasma and Cerebrospinal Fluid of Neonatal Sepsis Patients.

International journal of antimicrobial agents
2026

Safety and efficacy of direct versus conventional transfer to angiography suite in patients with severe acute stroke treated with thrombectomy (DIRECT ANGIO) in France: a multicentre, open-label, blinded-endpoint, randomised controlled trial.

The Lancet. Neurology
2026

Cell death in kidney transplantation: Mechanisms and therapeutic perspectives.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2026

Endothelial SMAD1-MCAM axis facilitates sunitinib resistance and progression of clear cell renal cell carcinoma via LAMB1-ITGB1 signaling.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
2026

Urinary metal mixtures and cardio-kidney-metabolic risk in adults from a legacy-contaminated area: Repeated-measures cohort evidence and computational validation.

Ecotoxicology and environmental safety
2026

Taurine attenuates diabetic nephropathy by suppressing the HMGB1/TLR4/MyD88/NF-κB axis in mice.

International immunopharmacology
2026

Efficacy of thiamine (vitamin B1) in sepsis and septic shock: A meta-analysis of randomized controlled trials.

Clinics (Sao Paulo, Brazil)
2026

Post-marketing safety evaluation of the live-attenuated chikungunya vaccine (IXCHIQ).

Vaccine
2026

Levels of serum electrolytes and trace elements in dogs with kidney failure undergoing hemodialysis: A sequential analysis.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
2026

Impact of uremia on platelet contribution to clot strength assessed with rotational thromboelastometry: A retrospective cohort study in septic patients.

Thrombosis research

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Atherosclerosis in chronic kidney disease-early prevention is better than late treatment.
    Kidney international· 2027· PMID 41848479mais citado
  2. DR5/WDR12 balances p65 stability promoting sunitinib resistance in renal cell carcinoma.
    Cell death and differentiation· 2026· PMID 41872532mais citado
  3. IFI16 is essential to linking DNA damage and ferroptosis in acute kidney injury.
    Cell death & disease· 2026· PMID 41872158mais citado
  4. SP/NK-1 pathogenic signaling drives doxorubicin nephrotoxicity: Novel therapeutic role of MK-0869 via modulation of α-Klotho, RAS, and Wnt/β-catenin trajectories.
    Life sciences· 2026· PMID 41871660mais citado
  5. The m5C orchestrator NSUN7 drives SPARC/HMGB1 axis-mediated inflammation to exacerbate kidney injury.
    Proceedings of the National Academy of Sciences of the United States of America· 2026· PMID 41871257mais citado
  6. Hematuria as a biomarker guiding treatment decisions in IgA nephropathy? no.
    Nephrol Dial Transplant· 2026· PMID 41871343recente
  7. Nutritional paradoxes of the new Dietary Guidelines for Americans (2025-2030): a critical analysis.
    J Bras Nefrol· 2026· PMID 41871332recente
  8. ENDOTHELIUM-DERIVED ENDOTHELIN-1 MEDIATES SICKLE CELL NEPHROPATHY.
    Function (Oxf)· 2026· PMID 41871311recente
  9. Microhardness Variation in Calcium Oxalate Monohydrate Stones: A Potential Explanation for Fragment Formation During Laser Dusting.
    Urol Int· 2026· PMID 41871226recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:93545(Orphanet)
  2. MONDO:0019719(MONDO)
  3. GARD:19216(GARD (NIH))
  4. Variantes catalogadas(ClinVar)
  5. Q30899323(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Malformação renal ou do trato urinário
Compêndio · Raras BR

Malformação renal ou do trato urinário

ORPHA:93545 · MONDO:0019719
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UMLS
C1968949
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